DK1795598T3 - Hidtil ukendte peptider - Google Patents
Hidtil ukendte peptiderInfo
- Publication number
- DK1795598T3 DK1795598T3 DK07006224.5T DK07006224T DK1795598T3 DK 1795598 T3 DK1795598 T3 DK 1795598T3 DK 07006224 T DK07006224 T DK 07006224T DK 1795598 T3 DK1795598 T3 DK 1795598T3
- Authority
- DK
- Denmark
- Prior art keywords
- amino acid
- new peptides
- compound
- activity
- replaced
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/461—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from fish
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/463—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from amphibians
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/465—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from birds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4702—Regulators; Modulating activity
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/42—Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Zoology (AREA)
- Biophysics (AREA)
- Toxicology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Physical Education & Sports Medicine (AREA)
- Endocrinology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Rheumatology (AREA)
- Diabetes (AREA)
- Dermatology (AREA)
- Epidemiology (AREA)
- Hematology (AREA)
- Nutrition Science (AREA)
- Obesity (AREA)
- Pulmonology (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP21000299 | 1999-07-23 | ||
| JP33884199 | 1999-11-29 | ||
| JP2000126623 | 2000-04-26 | ||
| EP00946453A EP1197496B8 (en) | 1999-07-23 | 2000-07-24 | Novel peptides |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK1795598T3 true DK1795598T3 (da) | 2010-02-01 |
Family
ID=27329078
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK00946453T DK1197496T3 (da) | 1999-07-23 | 2000-07-24 | Hidtil ukendte peptider |
| DK07006224.5T DK1795598T3 (da) | 1999-07-23 | 2000-07-24 | Hidtil ukendte peptider |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK00946453T DK1197496T3 (da) | 1999-07-23 | 2000-07-24 | Hidtil ukendte peptider |
Country Status (16)
| Country | Link |
|---|---|
| US (5) | US7385026B1 (enExample) |
| EP (3) | EP1197496B8 (enExample) |
| JP (2) | JP3471780B2 (enExample) |
| KR (1) | KR100827973B1 (enExample) |
| CN (2) | CN100506844C (enExample) |
| AT (2) | ATE366813T1 (enExample) |
| AU (2) | AU784035B2 (enExample) |
| BR (2) | BR0012688A (enExample) |
| CA (2) | CA2380058C (enExample) |
| CY (2) | CY1107724T1 (enExample) |
| DE (2) | DE60043361D1 (enExample) |
| DK (2) | DK1197496T3 (enExample) |
| ES (3) | ES2288151T3 (enExample) |
| IL (2) | IL147652A0 (enExample) |
| PT (2) | PT1197496E (enExample) |
| WO (1) | WO2001007475A1 (enExample) |
Families Citing this family (61)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PT1197496E (pt) | 1999-07-23 | 2007-08-29 | Kenji Kangawa | Novos péptidos |
| CA2392019A1 (en) | 1999-11-22 | 2001-05-31 | Zymogenetics, Inc. | Method of forming a peptide-receptor complex with zsig33 |
| US6897286B2 (en) | 2000-05-11 | 2005-05-24 | Zymogenetics, Inc. | Zsig33-like peptides |
| EP1288230B1 (en) | 2000-05-12 | 2008-10-01 | Kaneka Corporation | Method of purifying vinyl polymer |
| CA2411667A1 (en) * | 2000-05-30 | 2001-12-06 | Merck & Co. Inc. | Ghrelin analogs |
| EP1303538A2 (en) * | 2000-07-24 | 2003-04-23 | Ardana Bioscience Limited | Ghrelin antagonists |
| AU2003236080B8 (en) * | 2002-04-11 | 2009-07-02 | Daiichi Sankyo Company, Limited | A method for producing a modified peptide |
| CN100411683C (zh) | 2002-05-21 | 2008-08-20 | 阿斯比奥制药株式会社 | 含有生长素释放肽的药物组合物 |
| KR20050027168A (ko) * | 2002-07-19 | 2005-03-17 | 사이토스 바이오테크놀로지 아게 | 그렐린-캐리어 컨쥬게이트 |
| DE60335913D1 (de) | 2002-07-23 | 2011-03-10 | Ipsen Pharma | Ghrelin-analoga |
| TWI331922B (en) * | 2002-08-09 | 2010-10-21 | Ipsen Pharma Sas | Growth hormone releasing peptides |
| CA2496687A1 (en) * | 2002-09-18 | 2004-04-01 | Centre Hospitalier De L'universite De Montreal (Chum) | Ghrh analogues |
| EP1407779A1 (en) * | 2002-10-10 | 2004-04-14 | Gastrotech A/S | Use of ghrelin for treating low body weight and body fat in gastrectomized individuals |
| KR20060015555A (ko) | 2003-04-30 | 2006-02-17 | 겐지 간가와 | 간 질환 예방 치료제 |
| WO2005016951A2 (en) * | 2003-06-04 | 2005-02-24 | Eli Lilly And Company | Anti-ghrelin fab antibodies |
| EP1670827A2 (en) * | 2003-09-05 | 2006-06-21 | Eli Lilly And Company | Anti-ghrelin antibodies |
| CN1321131C (zh) * | 2003-12-26 | 2007-06-13 | 李宁 | 猪Ghrelin衍生物及其编码基因与应用 |
| RU2006130006A (ru) * | 2004-01-20 | 2008-02-27 | Цитос Биотехнологи Аг (Ch) | Конъюгаты грелин-носитель |
| US7026175B2 (en) | 2004-03-29 | 2006-04-11 | Applied Materials, Inc. | High throughput measurement of via defects in interconnects |
| WO2005097831A2 (en) * | 2004-04-07 | 2005-10-20 | Gastrotech Pharma A/S | Uses of isolated binding members capable of binding specifically to secretagogues |
| WO2005097830A2 (en) * | 2004-04-07 | 2005-10-20 | Aditech Pharma Ab | Uses of isolated binding members capable of reducing the biological activity of secretagogue compounds |
| US20080171700A1 (en) * | 2004-04-07 | 2008-07-17 | Gastrotech Pharma A/S | Use Of Secretagogue For The Teatment Of Ghrelin Deficiency |
| WO2005110463A1 (en) * | 2004-05-11 | 2005-11-24 | The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services, National Institutes Of Health | Methods of inhibiting proinflammatory cytokine expression using ghrelin |
| WO2005120484A1 (ja) * | 2004-06-09 | 2005-12-22 | Kurume University | グレリンの生理学的機能のレギュレーター |
| CA2569235A1 (en) * | 2004-07-14 | 2006-02-23 | Eli Lilly And Company | Anti-ghrelin antibodies |
| EP1812045A2 (en) * | 2004-10-27 | 2007-08-01 | Gastrotech Pharma A/S | Uses of secretagogues for treatment of organ transplant patients |
| EP1812044A2 (en) * | 2004-10-27 | 2007-08-01 | Gastrotech Pharma A/S | Uses of growth hormone secretagogues in the treatment of individuals suffering from renal and/or liver failure |
| US20080300180A1 (en) * | 2004-11-30 | 2008-12-04 | Gastrotech Pharma A/S | Growth Hormone Secretagogue Receptor 1A Ligands |
| RU2403058C2 (ru) * | 2005-02-23 | 2010-11-10 | Киото Юниверсити | Стимулятор регенерации панкреатических бета-клеток и продуцирования инсулина в панкреатических бета-клетках |
| WO2006091381A1 (en) * | 2005-02-23 | 2006-08-31 | Eli Lilly And Company | Humanized anti-ghrelin antibodies |
| RU2427587C2 (ru) * | 2005-09-28 | 2011-08-27 | Ипсен Фарма С.А.С. | Аналоги грелина |
| CA2625447C (en) | 2005-09-29 | 2015-06-09 | Societe De Conseils De Recherches Et D'applications Scientifiques S.A.S. | Compositions and methods for stimulating gastrointestinal motility |
| AU2006316101A1 (en) * | 2005-11-21 | 2007-05-24 | Daiichi Sankyo Company, Limited | Therapeutic agent for skin or skin repair-promoting agent comprising des-acylghrelin or derivative thereof as active ingredient |
| RU2420306C2 (ru) * | 2005-11-21 | 2011-06-10 | Юниверсити Оф Миязаки | ТЕРАПЕВТИЧЕСКОЕ СРЕДСТВО ДЛЯ УСКОРЕННОГО ЗАЖИВЛЕНИЯ КОЖИ, СОДЕРЖАЩЕЕ В КАЧЕСТВЕ АКТИВНОГО ИНГРЕДИЕНТА ГРЕЛИН И ЕГО ПРОИЗВОДНЫЕ ИЛИ ВЕЩЕСТВО, ВОЗДЕЙСТВУЮЩЕЕ НА РЕЦЕПТОР GHS-R1a |
| ES2424970T3 (es) * | 2006-03-10 | 2013-10-10 | Ipsen Pharma | Uso de un agonista de la grelina para mejorar los efectos catabólicos del tratamiento con glucocorticoides |
| KR101201055B1 (ko) | 2006-03-13 | 2012-11-15 | 리아트 민쯔 | 악액질 및/또는 식욕감퇴 및/또는 식욕감퇴-악액질 및/또는영양장애 및/또는 지방이영양증 및/또는 근육 쇠약 및/또는 식욕-자극의 치료를 위한 그렐린 스플라이스 변이체의 용도 |
| CA2659264C (en) * | 2006-08-01 | 2016-01-26 | The Scripps Research Institute | Immunoconjugates of ghrelin for use in vaccines and methods for controlling adiposity |
| WO2008018597A1 (fr) * | 2006-08-11 | 2008-02-14 | University Of Miyazaki | Agent thérapeutique permettant d'accélérer la réparation des nerfs rachidiens comprenant en tant que matière active de la désacyl ghréline ou un dérivé de celle-ci |
| CN101516400A (zh) | 2006-08-11 | 2009-08-26 | 国立大学法人宫崎大学 | 以生长素释放肽及其衍生物或作用于GHS-R1a的物质作为有效成分的脊髓神经修复促进治疗剂 |
| JP5134627B2 (ja) * | 2006-09-27 | 2013-01-30 | イプセン ファルマ ソシエテ パール アクシオン サンプリフィエ | N末端で置換されたグレリン類似体 |
| CA2698582C (en) | 2008-05-23 | 2016-09-13 | Asubio Pharma Co., Ltd. | Peptide having an extending action for half-life of object peptide in plasma |
| DK3178835T3 (da) | 2009-02-03 | 2019-06-24 | Amunix Pharmaceuticals Inc | Forlængede rekombinante polypeptider og sammensætninger omfattende samme |
| US9724381B2 (en) | 2009-05-12 | 2017-08-08 | The Administrators Of The Tulane Educational Fund | Methods of inhibiting the ghrelin/growth hormone secretatogue receptor pathway and uses thereof |
| US8883721B2 (en) * | 2009-05-12 | 2014-11-11 | Mcgill University | Methods of inhibiting the ghrelin/growth hormone secretatogue receptor pathway and uses thereof |
| JP6057314B2 (ja) | 2010-01-15 | 2017-01-11 | 国立大学法人 宮崎大学 | 加療中動物の回復促進治療剤 |
| EP2582715B1 (en) * | 2010-06-16 | 2018-11-28 | The Administrators of the Tulane Educational Fund | Growth hormone secretatogue receptor antagonists and uses thereof |
| BR112013021859A2 (pt) | 2011-03-03 | 2016-10-25 | Daiichi Sankyo Co Ltd | agente hipotérmico para um animal, agente hiportérmico, agente terapêutico para hipertermia em um animal, método para reduzir a temperatura corporal de um animal, método terapêutico para hipertermia em um animal, desacilada ou o seu derivado e uso de gralina desacilada ou o seu derivado |
| JP5560248B2 (ja) * | 2011-09-07 | 2014-07-23 | 花王株式会社 | ジペプチド誘導体及びその製造方法 |
| MX366864B (es) | 2012-02-27 | 2019-07-26 | Amunix Operating Inc | Composiciones de conjugados de xten y métodos para realizarlas. |
| CN104302177B (zh) | 2012-05-17 | 2019-05-28 | 延伸生物科学股份有限公司 | 用于改进的药物递送的载体 |
| US9486503B2 (en) | 2012-10-04 | 2016-11-08 | Shionogi & Co., Ltd. | Medicinal agent for suppressing malignant tumor metastasis |
| JP6262661B2 (ja) * | 2012-10-24 | 2018-01-17 | 第一三共株式会社 | 筋萎縮性側索硬化症治療剤 |
| JP6143270B2 (ja) * | 2013-01-31 | 2017-06-07 | 学校法人東京薬科大学 | マイオスタチン阻害ペプチド |
| JP6295247B2 (ja) * | 2013-03-25 | 2018-03-14 | ゼリア新薬工業株式会社 | 食後期の胃運動亢進剤 |
| US9789197B2 (en) | 2014-10-22 | 2017-10-17 | Extend Biosciences, Inc. | RNAi vitamin D conjugates |
| CA2964463C (en) | 2014-10-22 | 2024-02-13 | Extend Biosciences, Inc. | Therapeutic vitamin d conjugates |
| US9616109B2 (en) | 2014-10-22 | 2017-04-11 | Extend Biosciences, Inc. | Insulin vitamin D conjugates |
| CN109879935B (zh) * | 2019-03-04 | 2020-11-20 | 南京工业大学 | 一种多肽的液相合成方法 |
| KR20220131221A (ko) | 2019-11-13 | 2022-09-27 | 아뮤닉스 파마슈티컬스, 인크. | 바코드화된 xten 폴리펩티드 및 이의 조성물, 및 이의 제조 방법 및 사용 방법 |
| AU2023353057A1 (en) | 2022-09-30 | 2025-05-01 | Extend Biosciences, Inc. | Long-acting parathyroid hormone |
| CN120818010B (zh) * | 2025-09-18 | 2025-12-05 | 天津科技大学 | 一种来自植物乳杆菌属细胞外囊泡的短肽及其应用 |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5194596A (en) * | 1989-07-27 | 1993-03-16 | California Biotechnology Inc. | Production of vascular endothelial cell growth factor |
| US5350836A (en) * | 1989-10-12 | 1994-09-27 | Ohio University | Growth hormone antagonists |
| IL98910A0 (en) * | 1990-07-24 | 1992-07-15 | Polygen Holding Corp | Polypeptide compounds having growth hormone releasing activity and pharmaceutical compositions containing them |
| US5663146A (en) * | 1991-08-22 | 1997-09-02 | Administrators Of The Tulane Educational Fund | Polypeptide analogues having growth hormone releasing activity |
| DE69332471T2 (de) * | 1992-04-07 | 2003-08-28 | The Scripps Research Institute, La Jolla | Verfahren zur herstellung modifizierten proteine |
| HUP9801337A2 (hu) * | 1995-03-31 | 1998-08-28 | American Cyanamid Company | Növekedést elősegítő tulajdonsággal rendelkező peptidek |
| IL118473A0 (en) | 1995-06-02 | 1996-09-12 | Suntory Ltd | Staphylococcus aureus V8 protease genes coding therefor and a method for the production thereof |
| JP3982866B2 (ja) | 1996-03-04 | 2007-09-26 | アスビオファーマ株式会社 | 分泌型Kex2誘導体の製造方法 |
| CA2198966C (en) | 1996-03-04 | 2011-06-21 | Yuji Suzuki | Method for cleaving chimeric protein using processing enzyme |
| KR20010005701A (ko) | 1997-03-24 | 2001-01-15 | 리스 데브라 케이. | 모틸린 상동체 |
| CA2328895A1 (en) | 1998-06-02 | 1999-12-09 | Genentech, Inc. | Secreted and transmembrane polypeptides and nucleic acids encoding the same |
| CN1120846C (zh) * | 1999-02-13 | 2003-09-10 | 中国人民解放军军事医学科学院基础医学研究所 | 生长激素释放肽及其应用 |
| US6420521B1 (en) * | 1999-06-30 | 2002-07-16 | Zymogenetics, Inc. | Short gastrointestinal peptides |
| PT1197496E (pt) * | 1999-07-23 | 2007-08-29 | Kenji Kangawa | Novos péptidos |
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2000
- 2000-07-24 PT PT00946453T patent/PT1197496E/pt unknown
- 2000-07-24 CN CNB008104409A patent/CN100506844C/zh not_active Expired - Lifetime
- 2000-07-24 CN CN200910141231.3A patent/CN101693736B/zh not_active Expired - Lifetime
- 2000-07-24 DE DE60043361T patent/DE60043361D1/de not_active Expired - Lifetime
- 2000-07-24 AT AT00946453T patent/ATE366813T1/de active
- 2000-07-24 DK DK00946453T patent/DK1197496T3/da active
- 2000-07-24 DK DK07006224.5T patent/DK1795598T3/da active
- 2000-07-24 IL IL14765200A patent/IL147652A0/xx unknown
- 2000-07-24 ES ES00946453T patent/ES2288151T3/es not_active Expired - Lifetime
- 2000-07-24 ES ES07006224T patent/ES2335235T3/es not_active Expired - Lifetime
- 2000-07-24 PT PT07006224T patent/PT1795598E/pt unknown
- 2000-07-24 DE DE60035502T patent/DE60035502T2/de not_active Expired - Lifetime
- 2000-07-24 BR BR0012688-8A patent/BR0012688A/pt not_active IP Right Cessation
- 2000-07-24 EP EP00946453A patent/EP1197496B8/en not_active Expired - Lifetime
- 2000-07-24 ES ES09166974T patent/ES2401939T3/es not_active Expired - Lifetime
- 2000-07-24 BR BRPI0012688A patent/BRPI0012688B8/pt unknown
- 2000-07-24 AT AT07006224T patent/ATE449174T1/de active
- 2000-07-24 EP EP07006224A patent/EP1795598B1/en not_active Expired - Lifetime
- 2000-07-24 US US09/959,577 patent/US7385026B1/en not_active Expired - Lifetime
- 2000-07-24 CA CA2380058A patent/CA2380058C/en not_active Expired - Lifetime
- 2000-07-24 EP EP09166974A patent/EP2119785B1/en not_active Expired - Lifetime
- 2000-07-24 JP JP2001512558A patent/JP3471780B2/ja not_active Expired - Lifetime
- 2000-07-24 AU AU60231/00A patent/AU784035B2/en not_active Expired
- 2000-07-24 KR KR1020027000758A patent/KR100827973B1/ko not_active Expired - Lifetime
- 2000-07-24 WO PCT/JP2000/004907 patent/WO2001007475A1/ja not_active Ceased
- 2000-07-24 CA CA2696819A patent/CA2696819C/en not_active Expired - Lifetime
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2002
- 2002-01-15 IL IL147652A patent/IL147652A/en active IP Right Grant
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2003
- 2003-07-07 JP JP2003271241A patent/JP4227857B2/ja not_active Expired - Lifetime
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2006
- 2006-04-13 AU AU2006201580A patent/AU2006201580B2/en not_active Expired
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2007
- 2007-08-28 CY CY20071101137T patent/CY1107724T1/el unknown
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2008
- 2008-01-30 US US12/010,838 patent/US8227570B2/en not_active Expired - Fee Related
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2010
- 2010-01-05 CY CY20101100012T patent/CY1109714T1/el unknown
- 2010-03-22 US US12/728,495 patent/US9573986B2/en not_active Expired - Fee Related
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2011
- 2011-03-31 US US13/076,844 patent/US8524871B2/en not_active Expired - Fee Related
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2012
- 2012-06-12 US US13/494,673 patent/US9938332B2/en not_active Expired - Fee Related
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