AU784035B2 - Novel peptides - Google Patents
Novel peptides Download PDFInfo
- Publication number
- AU784035B2 AU784035B2 AU60231/00A AU6023100A AU784035B2 AU 784035 B2 AU784035 B2 AU 784035B2 AU 60231/00 A AU60231/00 A AU 60231/00A AU 6023100 A AU6023100 A AU 6023100A AU 784035 B2 AU784035 B2 AU 784035B2
- Authority
- AU
- Australia
- Prior art keywords
- amino acid
- peptide
- type compound
- group
- amino
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/461—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from fish
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/463—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from amphibians
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/465—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from birds
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
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- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4702—Regulators; Modulating activity
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- A—HUMAN NECESSITIES
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- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
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Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Zoology (AREA)
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- Obesity (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
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| AU2006201580A AU2006201580B2 (en) | 1999-07-23 | 2006-04-13 | Novel peptides |
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
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| JP2000126623 | 2000-04-26 | ||
| JP2000/126623 | 2000-04-26 | ||
| PCT/JP2000/004907 WO2001007475A1 (en) | 1999-07-23 | 2000-07-24 | Novel peptides |
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| AU2006201580A Division AU2006201580B2 (en) | 1999-07-23 | 2006-04-13 | Novel peptides |
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| AU2006201580A Expired AU2006201580B2 (en) | 1999-07-23 | 2006-04-13 | Novel peptides |
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| AU2006201580A Expired AU2006201580B2 (en) | 1999-07-23 | 2006-04-13 | Novel peptides |
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|---|---|
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| EP (3) | EP2119785B1 (enExample) |
| JP (2) | JP3471780B2 (enExample) |
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| CN (2) | CN101693736B (enExample) |
| AT (2) | ATE366813T1 (enExample) |
| AU (2) | AU784035B2 (enExample) |
| BR (2) | BR0012688A (enExample) |
| CA (2) | CA2696819C (enExample) |
| CY (2) | CY1107724T1 (enExample) |
| DE (2) | DE60035502T2 (enExample) |
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| IL (2) | IL147652A0 (enExample) |
| PT (2) | PT1197496E (enExample) |
| WO (1) | WO2001007475A1 (enExample) |
Families Citing this family (61)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN101693736B (zh) * | 1999-07-23 | 2020-09-11 | 寒川贤治 | 新的肽 |
| AU1925701A (en) * | 1999-11-22 | 2001-06-04 | Zymogenetics Inc. | Method of forming a peptide-receptor complex with zsig33 |
| US6897286B2 (en) | 2000-05-11 | 2005-05-24 | Zymogenetics, Inc. | Zsig33-like peptides |
| DE60135985D1 (de) | 2000-05-12 | 2008-11-13 | Kaneka Corp | Verfahren zur reinigung von vinylpolymer |
| CA2411667A1 (en) | 2000-05-30 | 2001-12-06 | Merck & Co. Inc. | Ghrelin analogs |
| CN1443198A (zh) * | 2000-07-24 | 2003-09-17 | 阿达纳生物科学有限公司 | Ghrelin拮抗剂 |
| US7138489B2 (en) | 2002-04-11 | 2006-11-21 | Daiichi Asubio Pharma Co., Ltd. | Method for producing a modified peptide |
| IL162796A0 (en) * | 2002-05-21 | 2005-11-20 | Kenji Kangawa | Medicinal compositions containing ghrelin |
| US20040076645A1 (en) * | 2002-07-19 | 2004-04-22 | Bachmann Martin F. | Ghrelin-carrier conjugates |
| RU2373220C2 (ru) * | 2002-07-23 | 2009-11-20 | Сосьете Де Консей Де Решерш Э Д`Аппликасьон Сьентифик (С.К.Р.А.С.) | Аналоги грелина |
| TWI331922B (en) | 2002-08-09 | 2010-10-21 | Ipsen Pharma Sas | Growth hormone releasing peptides |
| NZ539218A (en) * | 2002-09-18 | 2008-03-28 | Univ Montreal Ct Hospitalier Chum | Synthetic GHRH analogues of 29 amino acids or more |
| EP1407779A1 (en) | 2002-10-10 | 2004-04-14 | Gastrotech A/S | Use of ghrelin for treating low body weight and body fat in gastrectomized individuals |
| US10653637B2 (en) | 2003-04-30 | 2020-05-19 | Kenji Kangawa | Preventives or remedies for hepatopathy |
| WO2005016951A2 (en) * | 2003-06-04 | 2005-02-24 | Eli Lilly And Company | Anti-ghrelin fab antibodies |
| WO2005026211A2 (en) * | 2003-09-05 | 2005-03-24 | Eli Lilly And Company | Anti-ghrelin antibodies |
| CN1321131C (zh) * | 2003-12-26 | 2007-06-13 | 李宁 | 猪Ghrelin衍生物及其编码基因与应用 |
| KR20060128924A (ko) * | 2004-01-20 | 2006-12-14 | 사이토스 바이오테크놀로지 아게 | 그레린-담체 접합체 |
| US7026175B2 (en) | 2004-03-29 | 2006-04-11 | Applied Materials, Inc. | High throughput measurement of via defects in interconnects |
| WO2005097831A2 (en) * | 2004-04-07 | 2005-10-20 | Gastrotech Pharma A/S | Uses of isolated binding members capable of binding specifically to secretagogues |
| CA2603295A1 (en) * | 2004-04-07 | 2006-10-20 | Gastrotech Pharma A/S | Use of ghrelin for the treatment of hyperthyroidism |
| WO2005097830A2 (en) * | 2004-04-07 | 2005-10-20 | Aditech Pharma Ab | Uses of isolated binding members capable of reducing the biological activity of secretagogue compounds |
| EP1750745A1 (en) * | 2004-05-11 | 2007-02-14 | The United States of America, represented by the Secretary, Department of Health and Human Services | Methods of inhibiting proinflammatory cytokine expression using ghrelin |
| WO2005120484A1 (ja) * | 2004-06-09 | 2005-12-22 | Kurume University | グレリンの生理学的機能のレギュレーター |
| EP1776386A1 (en) * | 2004-07-14 | 2007-04-25 | Eli Lilly And Company | Anti-ghrelin antibodies |
| WO2006045319A2 (en) * | 2004-10-27 | 2006-05-04 | Gastrotech Pharma A/S | Uses of growth hormone secretagogues in the treatment of individuals suffering from renal and/or liver failure |
| WO2006045313A2 (en) * | 2004-10-27 | 2006-05-04 | Gastrotech Pharma A/S | Uses of secretagogues for treatment of organ transplant patients |
| JP2008521840A (ja) * | 2004-11-30 | 2008-06-26 | ガストロテック・ファルマ・アクティーゼルスカブ | 成長ホルモン分泌促進物質レセプター１ａリガンド |
| KR101295104B1 (ko) | 2005-02-23 | 2013-08-09 | 다이이찌 산쿄 가부시키가이샤 | 췌장 β 세포의 재생 촉진제 및 췌장 β 세포의 인슐린생산 촉진제 |
| EP1856154A1 (en) | 2005-02-23 | 2007-11-21 | Eli Lilly And Company | Humanized anti-ghrelin antibodies |
| RU2427587C2 (ru) * | 2005-09-28 | 2011-08-27 | Ипсен Фарма С.А.С. | Аналоги грелина |
| PT1937262T (pt) | 2005-09-29 | 2019-08-21 | Ipsen Pharma Sas | Composição para utilização no tratamento de dismotilidade gastrointestinal |
| BRPI0618824A2 (pt) * | 2005-11-21 | 2011-09-13 | Univ Miyazaki | agente terapêutico acelerador de recuperação dérmica contendo grelina e derivados desta ou substáncias que atuam sobre ghs-r1a como ingrediente ativo |
| AU2006316101A1 (en) * | 2005-11-21 | 2007-05-24 | Daiichi Sankyo Company, Limited | Therapeutic agent for skin or skin repair-promoting agent comprising des-acylghrelin or derivative thereof as active ingredient |
| US20100227806A1 (en) * | 2006-03-10 | 2010-09-09 | Tulipano Giovanni | Use Of A Ghrelin Agonist To Improve Catabolic Effects Of Glucocorticoid Treatment |
| BRPI0708895A2 (pt) | 2006-03-13 | 2011-06-28 | Liat Mintz | uso de variante de junção de grelina para tratar caquexia e/ou anorexia e/ou anorexia-caquexia e/ou subnutrição e/ou lipodistrofia e/ou atrofia muscular e/ou estimulação do apetite |
| EA200970166A1 (ru) * | 2006-08-01 | 2009-06-30 | Дзе Скриппс Рисерч Инститьют | Вакцины и способы для регуляции ожирения |
| BRPI0715809A2 (pt) | 2006-08-11 | 2014-11-25 | Univ Miyazaki | Agente terapêutico para a aceleração da restauração do nervo espinhal compreendendo grelina, seus derivados ou substâncias capazes de atuar sobre o ghs-r1a como ingrediente ativo. |
| WO2008018597A1 (fr) * | 2006-08-11 | 2008-02-14 | University Of Miyazaki | Agent thérapeutique permettant d'accélérer la réparation des nerfs rachidiens comprenant en tant que matière active de la désacyl ghréline ou un dérivé de celle-ci |
| EP2083842B1 (en) | 2006-09-27 | 2013-08-28 | Ipsen Pharma S.A.S. | Analogs of ghrelin substituted at the n-terminal |
| HRP20160303T1 (hr) | 2008-05-23 | 2016-04-22 | Daiichi Sankyo Company, Limited | Peptid koji je sposoban produljiti vrijeme polu-života pogodnih peptida u plazmi |
| SI2393828T1 (sl) | 2009-02-03 | 2017-01-31 | Amunix Operating Inc. | Podaljšani rekombinantni polipetidi in sestavki, ki jih obsegajo |
| US9724381B2 (en) | 2009-05-12 | 2017-08-08 | The Administrators Of The Tulane Educational Fund | Methods of inhibiting the ghrelin/growth hormone secretatogue receptor pathway and uses thereof |
| CA2761901C (en) * | 2009-05-12 | 2019-08-13 | The Administrators Of The Tulane Educational Fund | Methods of inhibiting the ghrelin/growth hormone secretatogue receptor pathway and uses thereof |
| JP6057314B2 (ja) | 2010-01-15 | 2017-01-11 | 国立大学法人 宮崎大学 | 加療中動物の回復促進治療剤 |
| AU2011268256B8 (en) | 2010-06-16 | 2016-12-22 | Mcgill University | Growth hormone secretatogue receptor antagonists and uses thereof |
| US9555077B2 (en) | 2011-03-03 | 2017-01-31 | University Of Miyazaki | Methods of lowering body temperature by administration of desacyl ghrelin or its derivative |
| JP5560248B2 (ja) * | 2011-09-07 | 2014-07-23 | 花王株式会社 | ジペプチド誘導体及びその製造方法 |
| CN104302408B (zh) | 2012-02-27 | 2016-12-14 | 阿穆尼克斯运营公司 | Xten缀合组合物和制造其的方法 |
| WO2013172967A1 (en) | 2012-05-17 | 2013-11-21 | Extend Biosciences, Inc | Carriers for improved drug delivery |
| JP6218084B2 (ja) | 2012-10-04 | 2017-10-25 | 国立研究開発法人国立循環器病研究センター | 悪性腫瘍転移抑制用医薬 |
| CA2889499C (en) | 2012-10-24 | 2019-09-10 | Daiichi Sankyo Company, Limited | Growth hormone secretagogue receptor agonists for treating amyotrophic lateral sclerosis |
| WO2014119753A1 (ja) * | 2013-01-31 | 2014-08-07 | 学校法人 東京薬科大学 | マイオスタチン阻害ペプチド |
| US9682126B2 (en) * | 2013-03-25 | 2017-06-20 | Zeria Pharmaceutical Co., Ltd. | Postprandial gastrokinetic agent |
| WO2016065052A1 (en) | 2014-10-22 | 2016-04-28 | Extend Biosciences, Inc. | Insulin vitamin d conjugates |
| US9789197B2 (en) | 2014-10-22 | 2017-10-17 | Extend Biosciences, Inc. | RNAi vitamin D conjugates |
| US9585934B2 (en) | 2014-10-22 | 2017-03-07 | Extend Biosciences, Inc. | Therapeutic vitamin D conjugates |
| CN109879935B (zh) * | 2019-03-04 | 2020-11-20 | 南京工业大学 | 一种多肽的液相合成方法 |
| JP7725466B2 (ja) | 2019-11-13 | 2025-08-19 | アムニクス ファーマシューティカルズ， インコーポレイテッド | バーコード化されたｘｔｅｎポリペプチドおよびその組成物、ならびにその作製および使用方法 |
| US12233115B2 (en) | 2022-09-30 | 2025-02-25 | Extend Biosciences, Inc. | Long-acting parathyroid hormone |
| CN120818010B (zh) * | 2025-09-18 | 2025-12-05 | 天津科技大学 | 一种来自植物乳杆菌属细胞外囊泡的短肽及其应用 |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5194596A (en) * | 1989-07-27 | 1993-03-16 | California Biotechnology Inc. | Production of vascular endothelial cell growth factor |
| US5350836A (en) * | 1989-10-12 | 1994-09-27 | Ohio University | Growth hormone antagonists |
| IL98910A0 (en) * | 1990-07-24 | 1992-07-15 | Polygen Holding Corp | Polypeptide compounds having growth hormone releasing activity and pharmaceutical compositions containing them |
| US5663146A (en) * | 1991-08-22 | 1997-09-02 | Administrators Of The Tulane Educational Fund | Polypeptide analogues having growth hormone releasing activity |
| JP3712261B2 (ja) * | 1992-04-07 | 2005-11-02 | ザ スクリップス リサーチ インスティテュート | 修飾タンパク質の製造方法 |
| JPH11502844A (ja) * | 1995-03-31 | 1999-03-09 | アメリカン・サイアナミド・カンパニー | 成長促進特性を持つペプチド |
| IL118473A0 (en) | 1995-06-02 | 1996-09-12 | Suntory Ltd | Staphylococcus aureus V8 protease genes coding therefor and a method for the production thereof |
| JP3982866B2 (ja) | 1996-03-04 | 2007-09-26 | アスビオファーマ株式会社 | 分泌型Ｋｅｘ２誘導体の製造方法 |
| CA2198966C (en) | 1996-03-04 | 2011-06-21 | Yuji Suzuki | Method for cleaving chimeric protein using processing enzyme |
| CA2284733C (en) * | 1997-03-24 | 2010-10-26 | Zymogenetics, Inc. | Motilin homologs |
| CA2328895A1 (en) | 1998-06-02 | 1999-12-09 | Genentech, Inc. | Secreted and transmembrane polypeptides and nucleic acids encoding the same |
| CN1120846C (zh) * | 1999-02-13 | 2003-09-10 | 中国人民解放军军事医学科学院基础医学研究所 | 生长激素释放肽及其应用 |
| US6420521B1 (en) * | 1999-06-30 | 2002-07-16 | Zymogenetics, Inc. | Short gastrointestinal peptides |
| CN101693736B (zh) | 1999-07-23 | 2020-09-11 | 寒川贤治 | 新的肽 |
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