JP2011004753A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2011004753A5 JP2011004753A5 JP2010174020A JP2010174020A JP2011004753A5 JP 2011004753 A5 JP2011004753 A5 JP 2011004753A5 JP 2010174020 A JP2010174020 A JP 2010174020A JP 2010174020 A JP2010174020 A JP 2010174020A JP 2011004753 A5 JP2011004753 A5 JP 2011004753A5
- Authority
- JP
- Japan
- Prior art keywords
- nucleic acid
- acid molecule
- antigenic
- antigen
- antibody
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP03450087 | 2003-04-15 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006505135A Division JP2007525157A (ja) | 2003-04-15 | 2004-04-15 | 肺炎連鎖球菌抗原 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012099977A Division JP2012184236A (ja) | 2003-04-15 | 2012-04-25 | 肺炎連鎖球菌抗原 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2011004753A JP2011004753A (ja) | 2011-01-13 |
| JP2011004753A5 true JP2011004753A5 (enExample) | 2011-03-10 |
Family
ID=33186037
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006505135A Pending JP2007525157A (ja) | 2003-04-15 | 2004-04-15 | 肺炎連鎖球菌抗原 |
| JP2010174020A Pending JP2011004753A (ja) | 2003-04-15 | 2010-08-02 | 肺炎連鎖球菌抗原 |
| JP2012099977A Pending JP2012184236A (ja) | 2003-04-15 | 2012-04-25 | 肺炎連鎖球菌抗原 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006505135A Pending JP2007525157A (ja) | 2003-04-15 | 2004-04-15 | 肺炎連鎖球菌抗原 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012099977A Pending JP2012184236A (ja) | 2003-04-15 | 2012-04-25 | 肺炎連鎖球菌抗原 |
Country Status (7)
| Country | Link |
|---|---|
| US (3) | US7635487B2 (enExample) |
| EP (11) | EP2333114A1 (enExample) |
| JP (3) | JP2007525157A (enExample) |
| CN (2) | CN1774447B (enExample) |
| AU (1) | AU2004230244B2 (enExample) |
| CA (1) | CA2522238A1 (enExample) |
| WO (1) | WO2004092209A2 (enExample) |
Families Citing this family (67)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6800744B1 (en) | 1997-07-02 | 2004-10-05 | Genome Therapeutics Corporation | Nucleic acid and amino acid sequences relating to Streptococcus pneumoniae for diagnostics and therapeutics |
| US7128918B1 (en) | 1998-12-23 | 2006-10-31 | Id Biomedical Corporation | Streptococcus antigens |
| EP1456231A2 (en) | 2001-12-20 | 2004-09-15 | Shire Biochem Inc. | Streptococcus antigens |
| CN1909921B (zh) * | 2003-11-10 | 2012-09-26 | Uab研究基金会 | 减少细菌携带和中枢神经系统侵害的组合物及其使用方法 |
| EP2059807B1 (en) * | 2006-08-17 | 2013-02-20 | The UAB Research Foundation | Diagnosing pneumococcal pneumonia |
| US8722055B2 (en) | 2006-09-27 | 2014-05-13 | St. Jude Children's Research Hospital | Synthetic Streptococcus pneumoniae vaccine |
| EP1923069A1 (en) * | 2006-11-20 | 2008-05-21 | Intercell AG | Peptides protective against S. pneumoniae and compositions, methods and uses relating thereto |
| MX2009012676A (es) | 2007-05-23 | 2010-02-12 | Uab Research Foundation | Neuraminidasa neumococica no toxica y sus usos. |
| ES2381613T3 (es) * | 2007-05-25 | 2012-05-29 | Novartis Ag | Antígenos de pilus de streptococcus pneumoniae |
| CN101802198B (zh) * | 2007-07-23 | 2016-02-17 | 圣诺菲·帕斯图尔有限公司 | 免疫原性多肽和单克隆抗体 |
| US20160228500A9 (en) * | 2007-07-23 | 2016-08-11 | Martina Ochs | Immunogenic Polypeptides and Monoclonal Antibodies |
| GB0714963D0 (en) * | 2007-08-01 | 2007-09-12 | Novartis Ag | Compositions comprising antigens |
| JP5697991B2 (ja) * | 2008-02-01 | 2015-04-08 | サノフィ パストゥール リミテッドSanofi Pasteur Limited | 診断的アッセイ |
| ES2546213T3 (es) | 2008-03-03 | 2015-09-21 | Novartis Ag | Compuestos y composiciones como moduladores de la actividad de TLR |
| CN101977927A (zh) * | 2008-03-17 | 2011-02-16 | 英特塞尔股份公司 | 针对肺炎链球菌保护的肽以及与其有关的组合物、方法和用途 |
| EP2108656A1 (en) * | 2008-03-19 | 2009-10-14 | Beninati, Concetta | Antigenic protein fragments of streptococcus pneumoniae |
| US8348429B2 (en) | 2008-03-27 | 2013-01-08 | Doheny Eye Institute | Optical coherence tomography device, method, and system |
| US11839430B2 (en) | 2008-03-27 | 2023-12-12 | Doheny Eye Institute | Optical coherence tomography-based ophthalmic testing methods, devices and systems |
| US20110171224A1 (en) * | 2008-05-22 | 2011-07-14 | Orihuela Carlos J | PsrP IS A PROTECTIVE ANTIGEN AGAINST PNEUMOCOCCAL INFECTION |
| WO2010009450A1 (en) | 2008-07-18 | 2010-01-21 | Doheny Eye Institute | Optical coherence tomography device, method, and system |
| ES2352704B1 (es) * | 2008-08-08 | 2012-06-14 | CONSEJO SUPERIOR DE INVESTIGACIONES CIENTÍFICAS (CSIC)(Titular al 80%) | Secuencia de nucleotido y proteina b-galactosidasa de streptococcus mitis, procedimiento de obtencion y sus aplicaciones. |
| WO2010025584A1 (zh) * | 2008-09-04 | 2010-03-11 | Wang Lei | 表达发卡rna的dna分子及其构建方法和应用 |
| WO2010029546A2 (en) * | 2008-09-11 | 2010-03-18 | Ben Gurion University Of The Negev Research And Development Authority | Compositions and methods for treating s.pneumoniae infection |
| EP2218457B1 (en) * | 2009-02-16 | 2011-09-07 | Karlsruher Institut für Technologie | CD44v6 peptides as inhibitors of bacterial infections |
| US20120064103A1 (en) | 2009-03-24 | 2012-03-15 | Novartis Ag | Combinations of meningococcal factor h binding protein and pneumococcal saccharide conjugates |
| CA2765112A1 (en) | 2009-06-10 | 2010-12-16 | Novartis Ag | Benzonaphthyridine-containing vaccines |
| CN107126557A (zh) | 2009-06-29 | 2017-09-05 | 健诺西生物科学公司 | 抗肺炎链球菌的疫苗和组合物 |
| AU2010290896B2 (en) | 2009-09-02 | 2014-07-03 | Glaxosmithkline Biologicals S.A. | Immunogenic compositions including TLR activity modulators |
| JO3257B1 (ar) | 2009-09-02 | 2018-09-16 | Novartis Ag | مركبات وتركيبات كمعدلات لفاعلية tlr |
| WO2011030218A1 (en) | 2009-09-10 | 2011-03-17 | Novartis Ag | Combination vaccines against respiratory tract diseases |
| WO2011057148A1 (en) | 2009-11-05 | 2011-05-12 | Irm Llc | Compounds and compositions as tlr-7 activity modulators |
| US9408907B2 (en) | 2009-12-15 | 2016-08-09 | Glaxosmithkline Biologicals Sa | Homogenous suspension of immunopotentiating compounds and uses thereof |
| EP3165531B1 (en) | 2010-03-12 | 2020-11-25 | Children's Medical Center Corporation | Immunogenic composition, vaccine, and uses thereof |
| AU2011232421B2 (en) | 2010-03-23 | 2015-08-13 | Novartis Ag | Compounds (cystein based lipopeptides) and compositions as TLR2 agonists used for treating infections, inflammations, respiratory diseases etc. |
| WO2012072769A1 (en) | 2010-12-01 | 2012-06-07 | Novartis Ag | Pneumococcal rrgb epitopes and clade combinations |
| WO2012075428A1 (en) | 2010-12-03 | 2012-06-07 | Sanofi Pasteur Limited | Composition for immunization against streptococcus pneumoniae |
| WO2012100234A1 (en) | 2011-01-20 | 2012-07-26 | Genocea Biosciences, Inc. | Vaccines and compositions against streptococcus pneumoniae |
| CN108840912B (zh) | 2011-05-11 | 2023-07-04 | 儿童医疗中心有限公司 | 修饰的生物素结合蛋白及其融合蛋白和应用 |
| WO2013068949A1 (en) | 2011-11-07 | 2013-05-16 | Novartis Ag | Carrier molecule comprising a spr0096 and a spr2021 antigen |
| WO2013124473A1 (en) * | 2012-02-24 | 2013-08-29 | Novartis Ag | Pilus proteins and compositions |
| CN104519910B (zh) | 2012-03-07 | 2017-05-03 | 诺华股份有限公司 | 肺炎链球菌抗原的含佐剂制剂 |
| RU2014151567A (ru) | 2012-05-22 | 2016-07-10 | Новартис Аг | Конъюгат менингококка серогруппы х |
| RU2510281C2 (ru) | 2012-06-22 | 2014-03-27 | Общество с ограниченной ответственностью "Эпитоп" (ООО "Эпитоп") | ВАКЦИНА ПРОТИВ ПНЕВМОНИИ, ВЫЗЫВАЕМОЙ Streptococcus pneumoniae, НА ОСНОВЕ ГИБРИДНОГО БЕЛКА |
| WO2014018904A1 (en) * | 2012-07-26 | 2014-01-30 | Genocea Biosciences, Inc. | Fused antigen vaccines and compositions against streptococcus pneumoniae |
| TR201807340T4 (tr) | 2013-02-01 | 2018-06-21 | Glaxosmithkline Biologicals Sa | Çan benzeri reseptör agonistleri içeren immünolojik kompozisyonların intradermal yoldan verilmesi. |
| CA2900008C (en) | 2013-02-07 | 2025-10-07 | Children's Medical Center Corporation | PROTEIN ANTIGENS THAT CONFER PROTECTION AGAINST COLONIZATION AND/OR PNEUMOCOCCAL DISEASE |
| US10772497B2 (en) | 2014-09-12 | 2020-09-15 | Envision Diagnostics, Inc. | Medical interfaces and other medical devices, systems, and methods for performing eye exams |
| US9226856B2 (en) | 2013-03-14 | 2016-01-05 | Envision Diagnostics, Inc. | Inflatable medical interfaces and other medical devices, systems, and methods |
| US12539031B2 (en) | 2013-03-14 | 2026-02-03 | Envision Diagnostics, Inc. | Medical interfaces and other medical devices, systems, and methods for performing eye exams |
| WO2016204265A1 (ja) * | 2015-06-18 | 2016-12-22 | 一般財団法人阪大微生物病研究会 | 肺炎球菌補体依存性殺菌能測定方法 |
| US11039741B2 (en) | 2015-09-17 | 2021-06-22 | Envision Diagnostics, Inc. | Medical interfaces and other medical devices, systems, and methods for performing eye exams |
| EP3448234A4 (en) | 2016-04-30 | 2019-05-01 | Envision Diagnostics, Inc. | MEDICAL DEVICES, SYSTEMS AND METHODS FOR PERFORMING EYE EXAMINATIONS AND EYES TRACKING |
| US10738338B2 (en) | 2016-10-18 | 2020-08-11 | The Research Foundation for the State University | Method and composition for biocatalytic protein-oligonucleotide conjugation and protein-oligonucleotide conjugate |
| WO2018175783A1 (en) * | 2017-03-22 | 2018-09-27 | Modernatx, Inc. | Rna bacterial vaccines |
| WO2018183475A1 (en) | 2017-03-28 | 2018-10-04 | Children's Medical Center Corporation | A multiple antigen presenting system (maps)-based staphylococcus aureus vaccine, immunogenic composition, and uses thereof |
| MX2019015524A (es) | 2017-06-23 | 2020-09-10 | Univ Maryland | Composiciones inmunogenicas. |
| PL3752182T3 (pl) | 2018-02-12 | 2024-11-25 | Inimmune Corporation | Ligandy receptorów toll-podobnych |
| GB201807380D0 (en) * | 2018-05-04 | 2018-06-20 | Karlsson Roger | Biomarkers for detecting microbial infection |
| TWI852943B (zh) | 2018-09-12 | 2024-08-21 | 美商兒童醫療中心公司 | 肺炎鏈球菌融合蛋白疫苗 |
| IL281204B2 (en) | 2018-09-12 | 2025-07-01 | Affinivax Inc | Multivalent pneumococcal vaccines |
| RU2701733C1 (ru) * | 2018-12-14 | 2019-10-01 | Федеральное государственное бюджетное научное учреждение "Институт экспериментальной медицины" (ФГБНУ "ИЭМ") | Живая вакцина на основе штамма пробиотиков ENTEROCOCCUS FAECIUM L3 для профилактики инфекции, вызванной STREPTOCOCCUS PNEUMONIE |
| CN111748535B (zh) * | 2019-03-28 | 2022-07-05 | 安徽华恒生物科技股份有限公司 | 一种丙氨酸脱氢酶突变体及其在发酵生产l-丙氨酸中的应用 |
| CA3198876A1 (en) | 2020-11-04 | 2022-05-12 | Eligo Bioscience | Cutibacterium acnes recombinant phages, method of production and uses thereof |
| GB202100097D0 (en) * | 2021-01-05 | 2021-02-17 | Univ Liverpool | Novel composition |
| AU2022342080A1 (en) | 2021-09-09 | 2024-03-28 | Affinivax, Inc. | Multivalent pneumococcal vaccines |
| AU2023283913A1 (en) * | 2022-06-07 | 2024-10-31 | Peking University First Hospital | Fusion protein containing truncated iga protease and use thereof |
| US20240053336A1 (en) * | 2022-08-12 | 2024-02-15 | Arizona Board Of Regents On Behalf Of Arizona State University | Anti-microbial antibody signatures of inflammatory bowel disease and uses thereof |
Family Cites Families (43)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US40000A (en) | 1863-09-15 | Improvement in sewing-machines | ||
| US4609231A (en) | 1984-12-24 | 1986-09-02 | Perfectdata Corporation | Floppy diskette storage container |
| US4946778A (en) | 1987-09-21 | 1990-08-07 | Genex Corporation | Single polypeptide chain binding molecules |
| KR970002255B1 (ko) | 1990-06-11 | 1997-02-26 | 넥스스타 파아마슈티컬드, 인크. | 핵산 리간드 |
| ATE169030T1 (de) | 1990-06-28 | 1998-08-15 | Hoechst Ag | Fusionsproteine mit immunglobulinanteilen, ihre herstellung und verwendung |
| KR0185426B1 (ko) | 1991-06-24 | 1999-04-01 | 로버트 피. 블랙버언 | 씨형 간염 바이러스 폴리펩티드 |
| WO1996002555A1 (en) | 1994-07-15 | 1996-02-01 | The University Of Iowa Research Foundation | Immunomodulatory oligonucleotides |
| AU700080B2 (en) * | 1995-06-07 | 1998-12-17 | Biochem Vaccines Inc. | Streptococcal heat shock proteins members of the HSP70 family |
| CO4600681A1 (es) | 1996-02-24 | 1998-05-08 | Boehringer Ingelheim Pharma | Composicion farmaceutica para la modulacion inmunitaria |
| AU743469C (en) | 1996-08-30 | 2004-02-12 | Rolf Bald | Mirror-symmetrical selection and evolution of nucleic acids |
| US5849902A (en) | 1996-09-26 | 1998-12-15 | Oligos Etc. Inc. | Three component chimeric antisense oligonucleotides |
| US5989912A (en) | 1996-11-21 | 1999-11-23 | Oligos Etc. Inc. | Three component chimeric antisense oligonucleotides |
| CA2271720A1 (en) * | 1996-10-31 | 1998-05-07 | Human Genome Sciences, Inc. | Streptococcus pneumoniae polynucleotides and sequences |
| JP2001510989A (ja) * | 1996-11-01 | 2001-08-07 | スミスクライン・ビーチャム・コーポレイション | 新規コーディング配列 |
| US6271000B1 (en) * | 1996-12-13 | 2001-08-07 | Eli Lilly And Company | Streptococcus pneumoniae gene sequence mraY |
| US6800744B1 (en) * | 1997-07-02 | 2004-10-05 | Genome Therapeutics Corporation | Nucleic acid and amino acid sequences relating to Streptococcus pneumoniae for diagnostics and therapeutics |
| DE19742706B4 (de) | 1997-09-26 | 2013-07-25 | Pieris Proteolab Ag | Lipocalinmuteine |
| DE19803453A1 (de) | 1998-01-30 | 1999-08-12 | Boehringer Ingelheim Int | Vakzine |
| EP1100921B1 (en) * | 1998-07-27 | 2007-05-02 | Sanofi Pasteur Limited | Streptococcus pneumoniae proteins and nucleic acid molecules |
| WO2000006738A2 (en) * | 1998-07-27 | 2000-02-10 | Microbial Technics Limited | NUCLEIC ACIDS AND PROTEINS FROM $i(STREPTOCOCCUS PNEUMONIAE) |
| US6951652B2 (en) * | 1998-07-29 | 2005-10-04 | Biosynth S.R.L. | Vaccine for prevention of gram-negative bacterial infections and endotoxin related diseases |
| AU2027400A (en) * | 1998-11-19 | 2000-06-05 | St. Jude Children's Research Hospital | Identification and characterization of novel pneumococcal choline binding proteins, cbpg and cbpd, and diagnostic and therapeutic uses thereof |
| KR100802198B1 (ko) * | 1998-12-23 | 2008-02-11 | 샤이어 바이오켐 인코포레이티드 | 신규한 스트렙토코커스 항원 |
| AT408721B (de) | 1999-10-01 | 2002-02-25 | Cistem Biotechnologies Gmbh | Pharmazeutische zusammensetzung enthaltend ein antigen |
| WO2001049721A2 (en) * | 1999-12-30 | 2001-07-12 | Bristol-Myers Squibb Company | Bacterial genes and proteins that are essential for cell viability and their uses |
| AT409085B (de) | 2000-01-28 | 2002-05-27 | Cistem Biotechnologies Gmbh | Pharmazeutische zusammensetzung zur immunmodulation und herstellung von vakzinen |
| ATE375169T1 (de) | 2000-04-14 | 2007-10-15 | Intercell Ag | Modifizierte peptide enthaltende pharmazeutische präparationen |
| AT410173B (de) | 2000-06-08 | 2003-02-25 | Cistem Biotechnologies Gmbh | Antigene zusammensetzung |
| WO2001093905A1 (en) | 2000-06-08 | 2001-12-13 | Intercell Biomedizinische Forschungs- Und Entwicklungs Ag | Immunostimulatory oligodeoxynucleotides |
| WO2002005448A1 (en) | 2000-07-10 | 2002-01-17 | Telefonaktiebolaget Lm Ericsson (Publ) | Resource management in uncoordinated frequency hopping system |
| AU2001289813B2 (en) | 2000-08-17 | 2005-07-28 | Intercell Ag | A vaccine which comprises at least one antigen and a cathelididin derived antimicrobial peptide or a derivative thereof |
| AT410635B (de) | 2000-10-18 | 2003-06-25 | Cistem Biotechnologies Gmbh | Vakzin-zusammensetzung |
| ATE439372T1 (de) | 2000-10-27 | 2009-08-15 | Novartis Vaccines & Diagnostic | Nukleinsäuren und proteine von gruppen a und b- streptokokken |
| AT410798B (de) | 2001-01-26 | 2003-07-25 | Cistem Biotechnologies Gmbh | Verfahren zur identifizierung, isolierung und herstellung von antigenen gegen ein spezifisches pathogen |
| BRPI0207447B1 (pt) | 2001-02-21 | 2015-09-22 | Id Biomedical Corp | polipeptídeo recombinante isolado, seu uso e processo de produção, vetor de expressão, célula hospedeira microbiana transgênica, composição farmacêutica, uso da dita composição, métodos de detecção e kit |
| AU2002306849A1 (en) * | 2001-03-21 | 2002-10-08 | Elitra Pharmaceuticals, Inc. | Identification of essential genes in microorganisms |
| GB0107658D0 (en) * | 2001-03-27 | 2001-05-16 | Chiron Spa | Streptococcus pneumoniae |
| JP2004533236A (ja) | 2001-04-13 | 2004-11-04 | ワイエス | 化膿性連鎖球菌(Streptococcuspyogenes)の表面タンパク質 |
| CN1636062A (zh) * | 2001-04-16 | 2005-07-06 | 惠氏控股公司 | 编码多肽抗原的新肺炎链球菌可读框及其应用 |
| FR2824074A1 (fr) | 2001-04-26 | 2002-10-31 | Pasteur Institut | Sequence du genome streptococcus agalactiae, application au developpement de vaccins, d'outils de diagnostic, et a l'identification de cibles therapeutiques |
| CA2452909A1 (en) | 2001-12-07 | 2003-06-13 | Intercell Ag | Immunostimulatory oligodeoxynucleotides |
| GB0210128D0 (en) | 2002-05-02 | 2002-06-12 | Chiron Spa | Nucleic acids and proteins from streptococcus groups A & B |
| JP4875490B2 (ja) | 2003-07-31 | 2012-02-15 | ノバルティス バクシンズ アンド ダイアグノスティックス,インコーポレーテッド | StreptococcusPyogenesについての免疫原組成物 |
-
2004
- 2004-04-15 EP EP10178937A patent/EP2333114A1/en not_active Withdrawn
- 2004-04-15 AU AU2004230244A patent/AU2004230244B2/en not_active Ceased
- 2004-04-15 EP EP04727537A patent/EP1615950A2/en not_active Withdrawn
- 2004-04-15 WO PCT/EP2004/003984 patent/WO2004092209A2/en not_active Ceased
- 2004-04-15 EP EP10178902A patent/EP2298934A1/en not_active Withdrawn
- 2004-04-15 EP EP10178910A patent/EP2336357A1/en not_active Withdrawn
- 2004-04-15 EP EP10178944A patent/EP2311989A1/en not_active Withdrawn
- 2004-04-15 CN CN200480010200XA patent/CN1774447B/zh not_active Expired - Fee Related
- 2004-04-15 CA CA002522238A patent/CA2522238A1/en not_active Abandoned
- 2004-04-15 EP EP10178893A patent/EP2314718A1/en not_active Withdrawn
- 2004-04-15 EP EP10178885A patent/EP2311988A1/en not_active Withdrawn
- 2004-04-15 US US10/552,156 patent/US7635487B2/en not_active Expired - Fee Related
- 2004-04-15 CN CN2011100423445A patent/CN102174534A/zh active Pending
- 2004-04-15 EP EP10178954A patent/EP2311991A1/en not_active Withdrawn
- 2004-04-15 EP EP10178877A patent/EP2311987A1/en not_active Withdrawn
- 2004-04-15 EP EP10178949A patent/EP2311990A1/en not_active Withdrawn
- 2004-04-15 JP JP2006505135A patent/JP2007525157A/ja active Pending
- 2004-04-15 EP EP10178932A patent/EP2314719A1/en not_active Withdrawn
-
2009
- 2009-12-14 US US12/637,589 patent/US8372411B2/en not_active Expired - Fee Related
-
2010
- 2010-08-02 JP JP2010174020A patent/JP2011004753A/ja active Pending
-
2012
- 2012-04-25 JP JP2012099977A patent/JP2012184236A/ja active Pending
-
2013
- 2013-01-31 US US13/755,399 patent/US20130136761A1/en not_active Abandoned