JP2009527226A5 - - Google Patents
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- Publication number
- JP2009527226A5 JP2009527226A5 JP2008555421A JP2008555421A JP2009527226A5 JP 2009527226 A5 JP2009527226 A5 JP 2009527226A5 JP 2008555421 A JP2008555421 A JP 2008555421A JP 2008555421 A JP2008555421 A JP 2008555421A JP 2009527226 A5 JP2009527226 A5 JP 2009527226A5
- Authority
- JP
- Japan
- Prior art keywords
- chimeric protein
- polypeptide
- host cell
- seq
- fragment
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 102000037865 fusion proteins Human genes 0.000 claims 17
- 108020001507 fusion proteins Proteins 0.000 claims 17
- 229920001184 polypeptide Polymers 0.000 claims 7
- 102000004196 processed proteins & peptides Human genes 0.000 claims 7
- 108090000765 processed proteins & peptides Proteins 0.000 claims 7
- 239000012634 fragment Substances 0.000 claims 4
- 238000012986 modification Methods 0.000 claims 4
- 230000004048 modification Effects 0.000 claims 4
- 102000039446 nucleic acids Human genes 0.000 claims 4
- 108020004707 nucleic acids Proteins 0.000 claims 4
- 150000007523 nucleic acids Chemical class 0.000 claims 4
- 125000003275 alpha amino acid group Chemical group 0.000 claims 3
- 238000000034 method Methods 0.000 claims 3
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 2
- 206010012735 Diarrhoea Diseases 0.000 claims 2
- 208000032759 Hemolytic-Uremic Syndrome Diseases 0.000 claims 2
- 241000282412 Homo Species 0.000 claims 2
- 241000124008 Mammalia Species 0.000 claims 2
- 108010079723 Shiga Toxin Proteins 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 241000588724 Escherichia coli Species 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 208000015181 infectious disease Diseases 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US77365806P | 2006-02-16 | 2006-02-16 | |
| US60/773,658 | 2006-02-16 | ||
| PCT/US2007/004513 WO2007098201A2 (en) | 2006-02-16 | 2007-02-16 | Shiga toxoid chimeric proteins |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2009527226A JP2009527226A (ja) | 2009-07-30 |
| JP2009527226A5 true JP2009527226A5 (enExample) | 2010-04-02 |
| JP5409014B2 JP5409014B2 (ja) | 2014-02-05 |
Family
ID=38437976
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008555421A Expired - Fee Related JP5409014B2 (ja) | 2006-02-16 | 2007-02-16 | 志賀トキソイドキメラタンパク質 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US8846058B2 (enExample) |
| EP (1) | EP1991565B1 (enExample) |
| JP (1) | JP5409014B2 (enExample) |
| CA (1) | CA2642451C (enExample) |
| ES (1) | ES2532985T3 (enExample) |
| WO (1) | WO2007098201A2 (enExample) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20030170248A1 (en) * | 1997-12-23 | 2003-09-11 | Jeffrey R. Stinson | Humanized monoclonal antibodies that protect against shiga toxin induced disease |
| EP1229045A1 (en) * | 2001-02-01 | 2002-08-07 | Institut Curie | Universal carrier for targeting molecules to Gb3 receptor expressing cells |
| CA2646319A1 (en) | 2006-04-20 | 2007-11-01 | The Henry M. Jackson Foundation For The Advancement Of Military Medicine , Incorporated | Methods and compositions based on shiga toxin type 1 protein |
| US20090258010A1 (en) * | 2006-05-31 | 2009-10-15 | Thallion Pharmaceuticals, Inc. | Methods, compositions, and kits for treating shiga toxin associated conditions |
| JP2009538916A (ja) * | 2006-05-31 | 2009-11-12 | タリオン ファーマシューティカルズ インコーポレーテッド | 志賀毒素関連病状を治療するための方法、組成物、およびキット |
| EP2207793A2 (en) * | 2007-10-08 | 2010-07-21 | Rutgers, The State University | Nontoxic shiga-like toxin mutant compositions and methods |
| NZ593926A (en) * | 2009-01-23 | 2013-03-28 | Jackson H M Found Military Med | Methods and compositions based on shiga toxin type 2 protein |
| CN101948546B (zh) * | 2010-09-25 | 2012-11-07 | 中国人民解放军军事医学科学院微生物流行病研究所 | 融合蛋白SAmB及其编码基因与应用 |
| CA3138799C (en) | 2012-02-24 | 2024-01-02 | Gen-Probe Prodesse, Inc. | Detection of shiga toxin genes in bacteria |
| US9513287B1 (en) * | 2012-09-28 | 2016-12-06 | The United States Of America, As Represented By The Secretary Of Agriculture | High affinity monoclonal antibodies for detection of shiga toxin 2 |
| US9310368B1 (en) * | 2012-09-28 | 2016-04-12 | The United States Of America, As Represented By The Secretary Of Agriculture | High affinity monoclonal antibodies for detection of Shiga toxin 2 (STX2) |
| RU2573924C2 (ru) * | 2013-07-11 | 2016-01-27 | Федеральное Государственное Бюджетное Учреждение Науки Институт Молекулярной Биологии Им. В.А. Энгельгардта Российской Академии Наук (Имб Ран) | НЕТОКСИЧНЫЙ РЕКОМБИНАНТНЫЙ ШИГА ТОКСИН 2-ГО ТИПА (Stx2) |
| KR20160113158A (ko) | 2014-01-27 | 2016-09-28 | 몰레큘러 템플레이츠, 인코퍼레이션. | 폴리펩티드를 전달하는 mhc 클래스 i 항원결정기 |
| US11142584B2 (en) | 2014-03-11 | 2021-10-12 | Molecular Templates, Inc. | CD20-binding proteins comprising Shiga toxin A subunit effector regions for inducing cellular internalization and methods using same |
| US10815469B2 (en) | 2014-06-11 | 2020-10-27 | Molecular Templates, Inc. | Cell-targeting molecules comprising protease-cleavage resistant, Shiga toxin A subunit effector polypeptides and carboxy-terminal moieties |
| JP6444486B2 (ja) | 2015-02-05 | 2018-12-26 | モレキュラー テンプレーツ, インク.Molecular Templates, Inc. | 志賀毒素ａサブユニットエフェクター領域を含む多価ｃｄ２０結合分子及びそれらの強化組成物 |
| JP6771492B2 (ja) | 2015-05-30 | 2020-10-21 | モレキュラー テンプレーツ, インク.Molecular Templates, Inc. | 脱免疫化された志賀毒素ａサブユニット足場及びそれを含む細胞標的化分子 |
| JP7075134B2 (ja) | 2016-12-07 | 2022-05-25 | モレキュラー テンプレーツ，インク． | 部位特異的コンジュゲーションのための志賀毒素ａサブユニットエフェクターポリペプチド、志賀毒素エフェクター足場、及び細胞標的化分子 |
| US11015205B2 (en) | 2016-12-22 | 2021-05-25 | Leibniz-Institut für Pflanzengenetik Und Kulturpflanzenforschung (IPK) | Oligomeric vaccines from plants by S-Tag-S-protein fusions |
| KR102590672B1 (ko) | 2017-01-25 | 2023-10-18 | 몰레큘러 템플레이츠, 인코퍼레이션. | 탈면역된 시가 독소 a 서브유닛 이펙터 및 cd8+ t-세포 에피토프를 포함하는 세포-표적화 분자 |
| MX2019009726A (es) | 2018-04-17 | 2020-02-05 | Molecular Templates Inc | Moleculas con direccion hacia her2 que comprenden andamiajes de la sub-unidad a de la toxina shiga desinmunizados. |
| CN111333734B (zh) * | 2020-03-31 | 2022-05-03 | 中国人民解放军军事科学院军事医学研究院 | 一种百日咳丝状血凝素融合蛋白及其应用 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5552144A (en) * | 1992-01-22 | 1996-09-03 | Microcarb, Inc. | Immunogenic shiga-like toxin II variant mutants |
| WO1998011229A2 (en) | 1996-09-10 | 1998-03-19 | Henry M. Jackson Foundation For The Advancement Of Military Medicine | Histidine-tagged shiga toxins, toxoids, and protein fusions with such toxins and toxoids, methods for the purification and preparation thereof |
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2007
- 2007-02-16 ES ES07751283.8T patent/ES2532985T3/es active Active
- 2007-02-16 WO PCT/US2007/004513 patent/WO2007098201A2/en not_active Ceased
- 2007-02-16 EP EP07751283.8A patent/EP1991565B1/en not_active Not-in-force
- 2007-02-16 JP JP2008555421A patent/JP5409014B2/ja not_active Expired - Fee Related
- 2007-02-16 CA CA2642451A patent/CA2642451C/en not_active Expired - Fee Related
- 2007-02-16 US US12/279,423 patent/US8846058B2/en not_active Expired - Fee Related