JP2012522522A5 - - Google Patents
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- Publication number
- JP2012522522A5 JP2012522522A5 JP2012503839A JP2012503839A JP2012522522A5 JP 2012522522 A5 JP2012522522 A5 JP 2012522522A5 JP 2012503839 A JP2012503839 A JP 2012503839A JP 2012503839 A JP2012503839 A JP 2012503839A JP 2012522522 A5 JP2012522522 A5 JP 2012522522A5
- Authority
- JP
- Japan
- Prior art keywords
- stec
- fusion protein
- epitope fusion
- composition
- epitope
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 102000037865 fusion proteins Human genes 0.000 claims 22
- 108020001507 fusion proteins Proteins 0.000 claims 22
- 102000004169 proteins and genes Human genes 0.000 claims 14
- 108090000623 proteins and genes Proteins 0.000 claims 14
- 241000282849 Ruminantia Species 0.000 claims 6
- 239000012472 biological sample Substances 0.000 claims 4
- 108091026890 Coding region Proteins 0.000 claims 3
- 125000003275 alpha amino acid group Chemical group 0.000 claims 3
- 150000001413 amino acids Chemical class 0.000 claims 3
- 230000002163 immunogen Effects 0.000 claims 3
- 238000000034 method Methods 0.000 claims 3
- 108091033319 polynucleotide Proteins 0.000 claims 3
- 102000040430 polynucleotide Human genes 0.000 claims 3
- 239000002157 polynucleotide Substances 0.000 claims 3
- FBUKMFOXMZRGRB-UHFFFAOYSA-N Coronaric acid Natural products CCCCCC=CCC1OC1CCCCCCCC(O)=O FBUKMFOXMZRGRB-UHFFFAOYSA-N 0.000 claims 2
- 241000588724 Escherichia coli Species 0.000 claims 2
- 101710170970 Leukotoxin Proteins 0.000 claims 2
- 241000124008 Mammalia Species 0.000 claims 2
- 108010079723 Shiga Toxin Proteins 0.000 claims 2
- 239000000427 antigen Substances 0.000 claims 2
- 102000036639 antigens Human genes 0.000 claims 2
- 108091007433 antigens Proteins 0.000 claims 2
- 239000000411 inducer Substances 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 229920001184 polypeptide Polymers 0.000 claims 2
- 102000004196 processed proteins & peptides Human genes 0.000 claims 2
- 108090000765 processed proteins & peptides Proteins 0.000 claims 2
- 241000283690 Bos taurus Species 0.000 claims 1
- 239000002671 adjuvant Substances 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 230000029142 excretion Effects 0.000 claims 1
- 239000012634 fragment Substances 0.000 claims 1
- 230000028993 immune response Effects 0.000 claims 1
- 230000001939 inductive effect Effects 0.000 claims 1
- 208000015181 infectious disease Diseases 0.000 claims 1
- 239000000523 sample Substances 0.000 claims 1
- 239000003053 toxin Substances 0.000 claims 1
- 231100000765 toxin Toxicity 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US21198909P | 2009-04-06 | 2009-04-06 | |
| US61/211,989 | 2009-04-06 | ||
| US21660809P | 2009-05-19 | 2009-05-19 | |
| US61/216,608 | 2009-05-19 | ||
| PCT/CA2010/000516 WO2010115278A1 (en) | 2009-04-06 | 2010-04-06 | Methods and compositions for treating and preventing shiga toxin-producing escherichia coli infection |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015172551A Division JP2016029049A (ja) | 2009-04-06 | 2015-09-02 | 志賀毒素産生大腸菌感染を処置及び予防するための方法並びに組成物 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2012522522A JP2012522522A (ja) | 2012-09-27 |
| JP2012522522A5 true JP2012522522A5 (enExample) | 2013-05-23 |
Family
ID=42935602
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012503839A Pending JP2012522522A (ja) | 2009-04-06 | 2010-04-06 | 志賀毒素産生大腸菌感染を処置及び予防するための方法並びに組成物 |
| JP2015172551A Pending JP2016029049A (ja) | 2009-04-06 | 2015-09-02 | 志賀毒素産生大腸菌感染を処置及び予防するための方法並びに組成物 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015172551A Pending JP2016029049A (ja) | 2009-04-06 | 2015-09-02 | 志賀毒素産生大腸菌感染を処置及び予防するための方法並びに組成物 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US8734811B2 (enExample) |
| EP (1) | EP2417165B1 (enExample) |
| JP (2) | JP2012522522A (enExample) |
| AU (1) | AU2010234193B2 (enExample) |
| BR (1) | BRPI1014505B1 (enExample) |
| CA (1) | CA2757828C (enExample) |
| WO (1) | WO2010115278A1 (enExample) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CL2014001126A1 (es) * | 2014-04-29 | 2014-08-29 | Univ Chile | Composición farmacéutica útil como vacuna contra bacterias escherichia coli productoras de shigatoxinas (stec), que comprende al menos un antígeno o una proteína de membrana externa inmunogénica o proteína inmunogénica asociada y conservada en cepas stec. |
| KR20220007619A (ko) * | 2019-05-01 | 2022-01-18 | 이네이트 바이올로직스 엘엘씨 | 면역조절 조성물 및 방법 |
| EP4054655A4 (en) * | 2019-11-08 | 2024-02-28 | Ionis Pharmaceuticals, Inc. | COMPOUNDS AND METHODS FOR REDUCING SPDEF EXPRESSION |
| US20210369836A1 (en) * | 2020-05-26 | 2021-12-02 | Synlogic Operating Company, Inc. | Surface display of proteins on recombinant bacteria and uses thereof |
| WO2024064200A2 (en) * | 2022-09-20 | 2024-03-28 | The Texas A&M University System | Darpin-containing compositions and methods thereof |
| AR132724A1 (es) | 2024-05-17 | 2025-07-23 | Instituto Nac De Tecnologia Agropecuaria Inta | Construcción de adn que codifica una proteína de fusión con al menos dos antígenos de escherichia coli enterohemorrágica, vectores, proteína de fusión, métodos de inmunización y vacunas |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5055400A (en) | 1986-11-26 | 1991-10-08 | University Of Guelph | Leukotoxin gene of pasteurella haemolytica |
| US4957739A (en) | 1987-08-13 | 1990-09-18 | Board Of Regents, The University Of Texas System | Pharmaceutical compositions of a 105 kD P. Haemolytica derived antigen useful for treatment of Shipping Fever |
| CA2014033C (en) | 1989-04-07 | 1993-02-09 | Stephen D. Acres | Compositions and treatments for pneumonia in animals |
| ES2108693T3 (es) * | 1990-04-05 | 1998-01-01 | Univ Saskatchewan | Compuestos y tratamientos para la neumonia en animales. |
| US5273889A (en) | 1990-08-22 | 1993-12-28 | University Of Saskatchewan | Gamma-iterferon-leukotoxin gene fusions and uses thereof |
| US5238823A (en) | 1990-08-22 | 1993-08-24 | Veterinary Infectious Disease Organization | Interleukin-2-leukotoxin gene fusions and uses thereof |
| US5594107A (en) * | 1990-08-22 | 1997-01-14 | University Of Saskatchewan | Chimeric protein comprising an RTX-family cytotoxin and interferon-2 or interferon |
| AU2699192A (en) | 1991-10-16 | 1993-05-21 | University Of Saskatchewan | Enhanced immunogenicity using leukotoxin chimeras |
| US5723129A (en) | 1991-10-16 | 1998-03-03 | University Of Saskatchewan | GnRH-leukotoxin chimeras |
| US5422110A (en) | 1991-10-16 | 1995-06-06 | University Of Saskatchewan | Enhanced immunogenicity using leukotoxin chimeras |
| US6797272B1 (en) | 1991-10-16 | 2004-09-28 | University Of Saskatchewan | Enhanced immunogenicity using leukotoxin chimeras |
| US5837268A (en) | 1991-10-16 | 1998-11-17 | University Of Saskatchewan | GnRH-leukotoxin chimeras |
| ES2389625T3 (es) | 1996-04-23 | 2012-10-29 | The University Of British Columbia | Vacuna que comprende la proteína EspA asociada a Escherichia coli patógena |
| EP1029054B1 (en) | 1997-11-12 | 2009-08-05 | The University Of British Columbia | Hp90: host membrane receptor for pathogenic bacteria, encoded by the bacterial tir gene |
| EP1098661A2 (en) * | 1998-06-04 | 2001-05-16 | Metamorphix, Inc. | Gnrh vaccines for suppressing reproductive behavior in animals |
| US6365723B1 (en) | 1998-12-04 | 2002-04-02 | Wisconsin Alumni Research Foundation | Sequences of E. coli O157 |
| MXPA03006042A (es) * | 2001-01-04 | 2005-02-14 | Univ British Columbia | Vacuna de escherichia colienterohemorragica. |
| AU2002347314A1 (en) * | 2002-11-29 | 2004-06-23 | Imperial College Innovations Limited | Vaccine against enteropathogenic and enterohaemorragic escherichia coli |
| WO2007101337A1 (en) * | 2006-03-06 | 2007-09-13 | Bioniche Life Sciences Inc. | Methods and compositions comprising bacterial type hi secreted proteins for mucosal immunization of animals |
| EP2420246A1 (en) * | 2006-04-20 | 2012-02-22 | The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc. | Methods and compositions based on shiga toxin type 1 protein |
-
2010
- 2010-04-06 JP JP2012503839A patent/JP2012522522A/ja active Pending
- 2010-04-06 WO PCT/CA2010/000516 patent/WO2010115278A1/en not_active Ceased
- 2010-04-06 AU AU2010234193A patent/AU2010234193B2/en not_active Ceased
- 2010-04-06 US US13/262,444 patent/US8734811B2/en active Active
- 2010-04-06 EP EP10761153.5A patent/EP2417165B1/en active Active
- 2010-04-06 BR BRPI1014505A patent/BRPI1014505B1/pt not_active IP Right Cessation
- 2010-04-06 CA CA2757828A patent/CA2757828C/en active Active
-
2015
- 2015-09-02 JP JP2015172551A patent/JP2016029049A/ja active Pending
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