JP2012515551A5 - - Google Patents
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- Publication number
- JP2012515551A5 JP2012515551A5 JP2011548095A JP2011548095A JP2012515551A5 JP 2012515551 A5 JP2012515551 A5 JP 2012515551A5 JP 2011548095 A JP2011548095 A JP 2011548095A JP 2011548095 A JP2011548095 A JP 2011548095A JP 2012515551 A5 JP2012515551 A5 JP 2012515551A5
- Authority
- JP
- Japan
- Prior art keywords
- antibody
- stx2
- seq
- fragment
- polypeptide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 229920001184 polypeptide Polymers 0.000 claims description 60
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 60
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 60
- 108010090763 Shiga Toxin 2 Proteins 0.000 claims description 49
- 238000000034 method Methods 0.000 claims description 31
- 239000012634 fragment Substances 0.000 claims description 30
- 108010079723 Shiga Toxin Proteins 0.000 claims description 24
- 201000010099 disease Diseases 0.000 claims description 20
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 20
- 125000003275 alpha amino acid group Chemical group 0.000 claims description 17
- 239000012472 biological sample Substances 0.000 claims description 9
- 210000004027 cell Anatomy 0.000 claims description 8
- 108090000623 proteins and genes Proteins 0.000 claims description 8
- 102000004169 proteins and genes Human genes 0.000 claims description 8
- 102000039446 nucleic acids Human genes 0.000 claims description 7
- 108020004707 nucleic acids Proteins 0.000 claims description 7
- 150000007523 nucleic acids Chemical class 0.000 claims description 7
- 108010091769 Shiga Toxin 1 Proteins 0.000 claims description 6
- 241000588724 Escherichia coli Species 0.000 claims description 5
- 208000032759 Hemolytic-Uremic Syndrome Diseases 0.000 claims description 5
- 241000607768 Shigella Species 0.000 claims description 5
- 208000015181 infectious disease Diseases 0.000 claims description 5
- 210000004408 hybridoma Anatomy 0.000 claims description 4
- 241000124008 Mammalia Species 0.000 claims description 3
- 239000002671 adjuvant Substances 0.000 claims description 3
- 238000000338 in vitro Methods 0.000 claims description 3
- 150000001413 amino acids Chemical class 0.000 claims description 2
- 238000001574 biopsy Methods 0.000 claims description 2
- 210000001124 body fluid Anatomy 0.000 claims description 2
- 239000010839 body fluid Substances 0.000 claims description 2
- 231100000433 cytotoxic Toxicity 0.000 claims description 2
- 230000001472 cytotoxic effect Effects 0.000 claims description 2
- 230000002255 enzymatic effect Effects 0.000 claims description 2
- 230000003053 immunization Effects 0.000 claims description 2
- 230000003834 intracellular effect Effects 0.000 claims description 2
- 238000006386 neutralization reaction Methods 0.000 claims description 2
- 239000000523 sample Substances 0.000 claims description 2
- 210000001519 tissue Anatomy 0.000 claims description 2
- 238000001514 detection method Methods 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 239000000203 mixture Substances 0.000 description 14
- 230000028993 immune response Effects 0.000 description 4
- 239000003937 drug carrier Substances 0.000 description 3
- 238000004519 manufacturing process Methods 0.000 description 2
- 230000004936 stimulating effect Effects 0.000 description 2
- 238000002965 ELISA Methods 0.000 description 1
- 102000017727 Immunoglobulin Variable Region Human genes 0.000 description 1
- 108010067060 Immunoglobulin Variable Region Proteins 0.000 description 1
- 238000003556 assay Methods 0.000 description 1
- 230000001580 bacterial effect Effects 0.000 description 1
- 208000001848 dysentery Diseases 0.000 description 1
- 238000000684 flow cytometry Methods 0.000 description 1
- 238000003018 immunoassay Methods 0.000 description 1
- 238000001114 immunoprecipitation Methods 0.000 description 1
- 230000001939 inductive effect Effects 0.000 description 1
- 244000052769 pathogen Species 0.000 description 1
- 230000001717 pathogenic effect Effects 0.000 description 1
- 239000008194 pharmaceutical composition Substances 0.000 description 1
- 238000003127 radioimmunoassay Methods 0.000 description 1
- 238000012216 screening Methods 0.000 description 1
- 238000001262 western blot Methods 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US14689209P | 2009-01-23 | 2009-01-23 | |
| US61/146,892 | 2009-01-23 | ||
| US21008209P | 2009-03-13 | 2009-03-13 | |
| US61/210,082 | 2009-03-13 | ||
| PCT/US2010/021610 WO2010085539A1 (en) | 2009-01-23 | 2010-01-21 | Methods and compositions based on shiga toxin type 2 protein |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2012515551A JP2012515551A (ja) | 2012-07-12 |
| JP2012515551A5 true JP2012515551A5 (enExample) | 2013-03-07 |
| JP5773886B2 JP5773886B2 (ja) | 2015-09-02 |
Family
ID=42356196
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011548095A Active JP5773886B2 (ja) | 2009-01-23 | 2010-01-21 | 志賀毒素タイプ２タンパク質に基づいた方法と組成物 |
Country Status (16)
| Country | Link |
|---|---|
| US (2) | US8969529B2 (enExample) |
| EP (1) | EP2381954B8 (enExample) |
| JP (1) | JP5773886B2 (enExample) |
| KR (1) | KR101832499B1 (enExample) |
| CN (1) | CN102292098A (enExample) |
| AR (1) | AR075047A1 (enExample) |
| AU (1) | AU2010206800B2 (enExample) |
| BR (1) | BRPI1007230B1 (enExample) |
| CA (1) | CA2748873C (enExample) |
| CL (1) | CL2011001769A1 (enExample) |
| ES (1) | ES2614803T3 (enExample) |
| MX (1) | MX2011007866A (enExample) |
| NZ (1) | NZ593926A (enExample) |
| PE (1) | PE20120425A1 (enExample) |
| RU (1) | RU2011126896A (enExample) |
| WO (1) | WO2010085539A1 (enExample) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1229045A1 (en) * | 2001-02-01 | 2002-08-07 | Institut Curie | Universal carrier for targeting molecules to Gb3 receptor expressing cells |
| MX2008013363A (es) | 2006-04-20 | 2009-03-26 | Jackson H M Found Military Med | Metodos y composiciones basados en la proteina tipo 1 de la toxina shiga. |
| CA2748873C (en) | 2009-01-23 | 2017-09-12 | The Henry M. Jackson Foundation For The Advancement Of Military Medicine, Inc. | Methods and compositions based on shiga toxin type 2 protein |
| US9513287B1 (en) * | 2012-09-28 | 2016-12-06 | The United States Of America, As Represented By The Secretary Of Agriculture | High affinity monoclonal antibodies for detection of shiga toxin 2 |
| US9310368B1 (en) * | 2012-09-28 | 2016-04-12 | The United States Of America, As Represented By The Secretary Of Agriculture | High affinity monoclonal antibodies for detection of Shiga toxin 2 (STX2) |
| CN105051067B (zh) * | 2013-03-12 | 2020-04-17 | 分子模板公司 | 用于引起细胞内化的cd20结合免疫毒素及其使用方法 |
| CN103343164B (zh) * | 2013-06-17 | 2016-05-18 | 武汉轻工大学 | 产志贺毒素大肠杆菌多重pcr检测方法、试剂盒及应用 |
| RU2573924C2 (ru) * | 2013-07-11 | 2016-01-27 | Федеральное Государственное Бюджетное Учреждение Науки Институт Молекулярной Биологии Им. В.А. Энгельгардта Российской Академии Наук (Имб Ран) | НЕТОКСИЧНЫЙ РЕКОМБИНАНТНЫЙ ШИГА ТОКСИН 2-ГО ТИПА (Stx2) |
| KR102500408B1 (ko) * | 2014-01-27 | 2023-02-16 | 몰레큘러 템플레이츠, 인코퍼레이션. | 포유류에 적용하기 위한 탈면역된 시가 독소 a 서브유닛 작동체 폴리펩티드 |
| US11142584B2 (en) | 2014-03-11 | 2021-10-12 | Molecular Templates, Inc. | CD20-binding proteins comprising Shiga toxin A subunit effector regions for inducing cellular internalization and methods using same |
| CN113831416A (zh) * | 2014-06-11 | 2021-12-24 | 分子模板公司 | 耐受蛋白酶切割的志贺毒素a亚基效应子多肽和包含其的细胞靶向分子 |
| CN104558167B (zh) * | 2014-12-26 | 2017-12-26 | 江苏省疾病预防控制中心 | 检测i型志贺毒素双抗夹心法酶联免疫试剂盒及其应用 |
| ES2856457T3 (es) | 2015-02-05 | 2021-09-27 | Molecular Templates Inc | Moléculas de unión a CD20 multivalentes que comprenden regiones efectoras de una subunidad de toxina shiga y composiciones enriquecidas de estas |
| US10676723B2 (en) | 2015-05-11 | 2020-06-09 | David Gordon Bermudes | Chimeric protein toxins for expression by therapeutic bacteria |
| CN107849096B (zh) | 2015-05-30 | 2022-05-24 | 分子模板公司 | 去免疫化的志贺毒素a亚基支架和包含它们的细胞靶向分子 |
| US11129906B1 (en) | 2016-12-07 | 2021-09-28 | David Gordon Bermudes | Chimeric protein toxins for expression by therapeutic bacteria |
| CN114773439A (zh) | 2016-12-07 | 2022-07-22 | 分子模板公司 | 用于位点特异性缀合的志贺毒素a亚基效应子多肽、志贺毒素效应子支架和细胞靶向分子 |
| MX2019008840A (es) | 2017-01-25 | 2019-09-09 | Molecular Templates Inc | Moleculas con direccion hacia las celulas que comprenden efectores de la sub-unidad a de la toxina shiga desinmunizados y epitopos de las celulas t cd8+. |
| AU2019257343A1 (en) | 2018-04-17 | 2020-09-10 | Molecular Templates, Inc. | HER2-targeting molecules comprising de-immunized, Shiga toxin A Subunit scaffolds |
| CN115856296B (zh) * | 2022-12-16 | 2023-07-25 | 华北理工大学 | 抗志贺氏菌的单克隆抗体及其检测中的应用 |
| CN120647752B (zh) * | 2025-08-19 | 2025-10-28 | 中国人民解放军军事科学院军事医学研究院 | 一种抗ⅱ型志贺毒素的单克隆抗体及其相关产品和应用 |
Family Cites Families (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8607679D0 (en) | 1986-03-27 | 1986-04-30 | Winter G P | Recombinant dna product |
| US5164298A (en) | 1988-06-24 | 1992-11-17 | Hsc Research Development Corporation | Verocytotoxin receptor assay |
| US6255458B1 (en) | 1990-08-29 | 2001-07-03 | Genpharm International | High affinity human antibodies and human antibodies against digoxin |
| WO1994004679A1 (en) | 1991-06-14 | 1994-03-03 | Genentech, Inc. | Method for making humanized antibodies |
| AU669124B2 (en) | 1991-09-18 | 1996-05-30 | Kyowa Hakko Kirin Co., Ltd. | Process for producing humanized chimera antibody |
| US5552144A (en) * | 1992-01-22 | 1996-09-03 | Microcarb, Inc. | Immunogenic shiga-like toxin II variant mutants |
| US5747272A (en) | 1994-02-14 | 1998-05-05 | Henry M. Jackson Foundation For The Advancement Of Military Medicine | Detection of shiga-like toxins of enterohemoragic Escherichia coli |
| US5968894A (en) | 1994-02-22 | 1999-10-19 | Lingwood; Clifford A. | Verotoxin pharmaceutical compositions and medical treatments therewith |
| EP0929679A2 (en) | 1996-09-10 | 1999-07-21 | Henry M. Jackson Foundation For The Advancement Of Military Medicine | Histidine-tagged shiga toxins, toxoids, and protein fusions with such toxins and toxoids, methods for the purification and preparation thereof |
| WO1998020903A1 (en) | 1996-11-15 | 1998-05-22 | Trustees Of Tufts College | Humanized neutralizing antibodies against hemolytic uremic syndrome |
| US7910096B2 (en) | 1996-11-15 | 2011-03-22 | Trustees Of Tufts College | Human neutralizing antibodies against hemolytic uremic syndrome |
| US20020160005A1 (en) * | 1996-11-15 | 2002-10-31 | Trustees Of Tufts College | Human neutralizing antibodies against hemolytic urmec syndrome |
| US20030170248A1 (en) * | 1997-12-23 | 2003-09-11 | Jeffrey R. Stinson | Humanized monoclonal antibodies that protect against shiga toxin induced disease |
| IL139571A0 (en) | 1998-05-20 | 2002-02-10 | Teijin Ltd | A humanized antibody that binds to verotoxin, methods for the production thereof and pharmaceutical compositions containing the same |
| ATE504312T1 (de) * | 2003-07-21 | 2011-04-15 | Intervet Int Bv | Hybrid-toxine mit shiga-artigen toxin- untereinheiten, verbunden mit escherichia coli wärmeinstabilen enterotoxin-untereinheiten und vakzine daraus |
| AU2004293502B2 (en) | 2003-11-28 | 2010-12-02 | National Research Council Of Canada | Anticarcinoma antibodies and uses thereof |
| JP2008507253A (ja) | 2004-02-06 | 2008-03-13 | ナイモックス コーポレーション | ヒト化抗体 |
| CA2458084A1 (en) | 2004-03-12 | 2005-09-12 | Dalton Chemical Laboratories Inc. | Novel process for octreotide synthesis |
| WO2006091677A1 (en) * | 2005-02-22 | 2006-08-31 | Jean Gariepy | Yeast strains expressing ribosome-inactivating protein domain and method of using same |
| ES2532985T3 (es) | 2006-02-16 | 2015-04-06 | The Henry M. Jackson Foundation For The Advancement Of Military Medicine, Inc. | Proteínas quiméricas de toxoide de Shiga |
| MX2008013363A (es) | 2006-04-20 | 2009-03-26 | Jackson H M Found Military Med | Metodos y composiciones basados en la proteina tipo 1 de la toxina shiga. |
| JP2009538916A (ja) | 2006-05-31 | 2009-11-12 | タリオン ファーマシューティカルズ インコーポレーテッド | 志賀毒素関連病状を治療するための方法、組成物、およびキット |
| US20090258010A1 (en) | 2006-05-31 | 2009-10-15 | Thallion Pharmaceuticals, Inc. | Methods, compositions, and kits for treating shiga toxin associated conditions |
| AU2007339753A1 (en) * | 2006-12-29 | 2008-07-10 | Osprey Pharmaceuticals Usa, Inc. | Methods of selecting and producing modified toxins, conjugates containing modified toxins and uses thereof |
| US20100298238A1 (en) | 2007-10-08 | 2010-11-25 | Rutgers, The State University | Nontoxic shiga-like toxin mutant compositions and methods |
| CN101314616B (zh) * | 2008-05-30 | 2011-05-11 | 中国人民解放军第三军医大学 | 肠出血性大肠杆菌o157:h7志贺毒素ⅱb表位肽及其应用 |
| US20110165680A1 (en) * | 2008-09-12 | 2011-07-07 | Scarab Genomics, Llc | Clean genome bactofection |
| CA2748873C (en) | 2009-01-23 | 2017-09-12 | The Henry M. Jackson Foundation For The Advancement Of Military Medicine, Inc. | Methods and compositions based on shiga toxin type 2 protein |
-
2010
- 2010-01-21 CA CA2748873A patent/CA2748873C/en active Active
- 2010-01-21 CN CN2010800052595A patent/CN102292098A/zh active Pending
- 2010-01-21 AU AU2010206800A patent/AU2010206800B2/en active Active
- 2010-01-21 EP EP10733840.2A patent/EP2381954B8/en active Active
- 2010-01-21 PE PE2011001368A patent/PE20120425A1/es not_active Application Discontinuation
- 2010-01-21 RU RU2011126896/10A patent/RU2011126896A/ru not_active Application Discontinuation
- 2010-01-21 US US13/142,556 patent/US8969529B2/en active Active
- 2010-01-21 ES ES10733840.2T patent/ES2614803T3/es active Active
- 2010-01-21 JP JP2011548095A patent/JP5773886B2/ja active Active
- 2010-01-21 MX MX2011007866A patent/MX2011007866A/es unknown
- 2010-01-21 NZ NZ593926A patent/NZ593926A/xx not_active IP Right Cessation
- 2010-01-21 KR KR1020117019455A patent/KR101832499B1/ko not_active Expired - Fee Related
- 2010-01-21 WO PCT/US2010/021610 patent/WO2010085539A1/en not_active Ceased
- 2010-01-21 BR BRPI1007230-6A patent/BRPI1007230B1/pt not_active IP Right Cessation
- 2010-01-22 AR ARP100100141A patent/AR075047A1/es not_active Application Discontinuation
-
2011
- 2011-07-21 CL CL2011001769A patent/CL2011001769A1/es unknown
-
2015
- 2015-02-23 US US14/628,667 patent/US9801931B2/en not_active Expired - Fee Related
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