JP2009536818A5 - - Google Patents
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- Publication number
- JP2009536818A5 JP2009536818A5 JP2009506629A JP2009506629A JP2009536818A5 JP 2009536818 A5 JP2009536818 A5 JP 2009536818A5 JP 2009506629 A JP2009506629 A JP 2009506629A JP 2009506629 A JP2009506629 A JP 2009506629A JP 2009536818 A5 JP2009536818 A5 JP 2009536818A5
- Authority
- JP
- Japan
- Prior art keywords
- antibody
- polypeptide
- stx1
- fragment
- composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000000034 method Methods 0.000 claims description 52
- 229920001184 polypeptide Polymers 0.000 claims description 52
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 52
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 52
- 108010091769 Shiga Toxin 1 Proteins 0.000 claims description 46
- 125000003275 alpha amino acid group Chemical group 0.000 claims description 37
- 239000012634 fragment Substances 0.000 claims description 37
- 108010079723 Shiga Toxin Proteins 0.000 claims description 29
- 201000010099 disease Diseases 0.000 claims description 26
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 26
- 108090000623 proteins and genes Proteins 0.000 claims description 17
- 102000004169 proteins and genes Human genes 0.000 claims description 17
- 239000012472 biological sample Substances 0.000 claims description 14
- 210000004027 cell Anatomy 0.000 claims description 10
- 102000037865 fusion proteins Human genes 0.000 claims description 10
- 108020001507 fusion proteins Proteins 0.000 claims description 10
- 101710167800 Capsid assembly scaffolding protein Proteins 0.000 claims description 8
- 101710130420 Probable capsid assembly scaffolding protein Proteins 0.000 claims description 8
- 101710204410 Scaffold protein Proteins 0.000 claims description 8
- 102000039446 nucleic acids Human genes 0.000 claims description 8
- 108020004707 nucleic acids Proteins 0.000 claims description 8
- 150000007523 nucleic acids Chemical class 0.000 claims description 8
- 241000588724 Escherichia coli Species 0.000 claims description 7
- 208000032759 Hemolytic-Uremic Syndrome Diseases 0.000 claims description 7
- 108010090763 Shiga Toxin 2 Proteins 0.000 claims description 6
- 241000607768 Shigella Species 0.000 claims description 6
- 230000028993 immune response Effects 0.000 claims description 6
- 208000015181 infectious disease Diseases 0.000 claims description 6
- 239000002671 adjuvant Substances 0.000 claims description 4
- 230000009918 complex formation Effects 0.000 claims description 4
- 239000003937 drug carrier Substances 0.000 claims description 4
- 210000004408 hybridoma Anatomy 0.000 claims description 4
- 150000001413 amino acids Chemical class 0.000 claims description 3
- 238000002965 ELISA Methods 0.000 claims description 2
- 102000017727 Immunoglobulin Variable Region Human genes 0.000 claims description 2
- 108010067060 Immunoglobulin Variable Region Proteins 0.000 claims description 2
- 241000124008 Mammalia Species 0.000 claims description 2
- 239000000427 antigen Substances 0.000 claims description 2
- 102000036639 antigens Human genes 0.000 claims description 2
- 108091007433 antigens Proteins 0.000 claims description 2
- 238000003556 assay Methods 0.000 claims description 2
- 238000001574 biopsy Methods 0.000 claims description 2
- 210000001124 body fluid Anatomy 0.000 claims description 2
- 239000010839 body fluid Substances 0.000 claims description 2
- 230000003013 cytotoxicity Effects 0.000 claims description 2
- 231100000135 cytotoxicity Toxicity 0.000 claims description 2
- 238000000684 flow cytometry Methods 0.000 claims description 2
- 230000003053 immunization Effects 0.000 claims description 2
- 238000003018 immunoassay Methods 0.000 claims description 2
- 238000001114 immunoprecipitation Methods 0.000 claims description 2
- 238000000338 in vitro Methods 0.000 claims description 2
- 230000001939 inductive effect Effects 0.000 claims description 2
- 238000006386 neutralization reaction Methods 0.000 claims description 2
- 239000000523 sample Substances 0.000 claims description 2
- 238000012216 screening Methods 0.000 claims description 2
- 230000004936 stimulating effect Effects 0.000 claims description 2
- 210000001519 tissue Anatomy 0.000 claims description 2
- 238000001262 western blot Methods 0.000 claims description 2
- 239000003053 toxin Substances 0.000 claims 1
- 231100000765 toxin Toxicity 0.000 claims 1
- 208000004429 Bacillary Dysentery Diseases 0.000 description 1
- 206010040550 Shigella infections Diseases 0.000 description 1
- 230000001413 cellular effect Effects 0.000 description 1
- 208000001848 dysentery Diseases 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 244000052769 pathogen Species 0.000 description 1
- 230000001717 pathogenic effect Effects 0.000 description 1
- 238000003127 radioimmunoassay Methods 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US79391806P | 2006-04-20 | 2006-04-20 | |
| PCT/US2007/009799 WO2007124133A2 (en) | 2006-04-20 | 2007-04-20 | Methods and compositions based on shiga toxin type 1 protein |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2009536818A JP2009536818A (ja) | 2009-10-22 |
| JP2009536818A5 true JP2009536818A5 (enExample) | 2011-05-06 |
Family
ID=38625659
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009506629A Pending JP2009536818A (ja) | 2006-04-20 | 2007-04-20 | 志賀毒性１型タンパク質に基づく方法および組成物 |
Country Status (7)
| Country | Link |
|---|---|
| US (3) | US8293245B2 (enExample) |
| EP (2) | EP2420246A1 (enExample) |
| JP (1) | JP2009536818A (enExample) |
| AU (1) | AU2007240614B2 (enExample) |
| CA (1) | CA2646319A1 (enExample) |
| MX (1) | MX2008013363A (enExample) |
| WO (1) | WO2007124133A2 (enExample) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20030170248A1 (en) * | 1997-12-23 | 2003-09-11 | Jeffrey R. Stinson | Humanized monoclonal antibodies that protect against shiga toxin induced disease |
| EP1229045A1 (en) | 2001-02-01 | 2002-08-07 | Institut Curie | Universal carrier for targeting molecules to Gb3 receptor expressing cells |
| WO2007124133A2 (en) | 2006-04-20 | 2007-11-01 | The Henry M. Jackson Foundation For The Advancement Of Military Medicine Incorporated | Methods and compositions based on shiga toxin type 1 protein |
| US20090258010A1 (en) * | 2006-05-31 | 2009-10-15 | Thallion Pharmaceuticals, Inc. | Methods, compositions, and kits for treating shiga toxin associated conditions |
| JP5773886B2 (ja) * | 2009-01-23 | 2015-09-02 | ザ ヘンリー エム． ジャクソン ファウンデーション フォー ザ アドヴァンスメント オブ ミリタリー メディシン インコーポレイテッド | 志賀毒素タイプ２タンパク質に基づいた方法と組成物 |
| EP2417165B1 (en) * | 2009-04-06 | 2016-05-25 | University Of Saskatchewan | Methods and compositions for treating and preventing shiga toxin-producing escherichia coli infection |
| CA2916518A1 (en) * | 2013-07-03 | 2015-01-08 | Roka Bioscience, Inc. | Compositions, kits, and related methods for detecting and/or monitoring shiga toxin producing escherichia coli |
| CN104558167B (zh) * | 2014-12-26 | 2017-12-26 | 江苏省疾病预防控制中心 | 检测i型志贺毒素双抗夹心法酶联免疫试剂盒及其应用 |
| CN120665951A (zh) * | 2018-02-07 | 2025-09-19 | 吉尼松公司 | 杂合调控元件 |
| RU2732155C1 (ru) * | 2019-09-24 | 2020-09-11 | Открытое акционерное общество "Всероссийский научный Центр молекулярной диагностики и лечения" (ОАО ВНЦМДЛ) | Гуманизированное антитело или его антигенсвязывающий фрагмент (Fab) против шига-токсинов первого и/или второго типов (варианты), композиция для лечения токсических состояний, вызванных энтерогеморрагической кишечной палочкой, содержащая указанные антитела и/или Fab |
Family Cites Families (47)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8308235D0 (en) | 1983-03-25 | 1983-05-05 | Celltech Ltd | Polypeptides |
| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| JPS6147500A (ja) | 1984-08-15 | 1986-03-07 | Res Dev Corp Of Japan | キメラモノクロ−ナル抗体及びその製造法 |
| EP0173494A3 (en) | 1984-08-27 | 1987-11-25 | The Board Of Trustees Of The Leland Stanford Junior University | Chimeric receptors by dna splicing and expression |
| GB8422238D0 (en) | 1984-09-03 | 1984-10-10 | Neuberger M S | Chimeric proteins |
| US4573986A (en) * | 1984-09-17 | 1986-03-04 | The Procter & Gamble Company | Disposable waste-containment garment |
| JPS61134325A (ja) | 1984-12-04 | 1986-06-21 | Teijin Ltd | ハイブリツド抗体遺伝子の発現方法 |
| EP0247091B1 (en) | 1985-11-01 | 1993-09-29 | Xoma Corporation | Modular assembly of antibody genes, antibodies prepared thereby and use |
| US5225539A (en) | 1986-03-27 | 1993-07-06 | Medical Research Council | Recombinant altered antibodies and methods of making altered antibodies |
| GB8607679D0 (en) | 1986-03-27 | 1986-04-30 | Winter G P | Recombinant dna product |
| JPS62292890A (ja) | 1986-06-13 | 1987-12-19 | Sanritsu Kikaku Kk | 固形潤滑材 |
| US4946778A (en) | 1987-09-21 | 1990-08-07 | Genex Corporation | Single polypeptide chain binding molecules |
| US5258498A (en) | 1987-05-21 | 1993-11-02 | Creative Biomolecules, Inc. | Polypeptide linkers for production of biosynthetic proteins |
| US5164298A (en) | 1988-06-24 | 1992-11-17 | Hsc Research Development Corporation | Verocytotoxin receptor assay |
| GB8823869D0 (en) | 1988-10-12 | 1988-11-16 | Medical Res Council | Production of antibodies |
| US5530101A (en) | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
| US6657103B1 (en) | 1990-01-12 | 2003-12-02 | Abgenix, Inc. | Human antibodies derived from immunized xenomice |
| US6150584A (en) | 1990-01-12 | 2000-11-21 | Abgenix, Inc. | Human antibodies derived from immunized xenomice |
| US6255458B1 (en) | 1990-08-29 | 2001-07-03 | Genpharm International | High affinity human antibodies and human antibodies against digoxin |
| AU8507191A (en) | 1990-08-29 | 1992-03-30 | Genpharm International, Inc. | Transgenic non-human animals capable of producing heterologous antibodies |
| US5545806A (en) | 1990-08-29 | 1996-08-13 | Genpharm International, Inc. | Ransgenic non-human animals for producing heterologous antibodies |
| WO1994004679A1 (en) | 1991-06-14 | 1994-03-03 | Genentech, Inc. | Method for making humanized antibodies |
| ATE166578T1 (de) | 1991-07-25 | 1998-06-15 | Idec Pharma Corp | Anregung von antworten zytotoxischer t- lymphozyten |
| US5756096A (en) | 1991-07-25 | 1998-05-26 | Idec Pharmaceuticals Corporation | Recombinant antibodies for human therapy |
| MX9204374A (es) | 1991-07-25 | 1993-03-01 | Idec Pharma Corp | Anticuerpo recombinante y metodo para su produccion. |
| US5709860A (en) | 1991-07-25 | 1998-01-20 | Idec Pharmaceuticals Corporation | Induction of cytotoxic T-lymphocyte responses |
| CA2078539C (en) | 1991-09-18 | 2005-08-02 | Kenya Shitara | Process for producing humanized chimera antibody |
| ES2301158T3 (es) | 1992-07-24 | 2008-06-16 | Amgen Fremont Inc. | Produccion de anticuerpos xenogenicos. |
| US5747272A (en) | 1994-02-14 | 1998-05-05 | Henry M. Jackson Foundation For The Advancement Of Military Medicine | Detection of shiga-like toxins of enterohemoragic Escherichia coli |
| US5968894A (en) | 1994-02-22 | 1999-10-19 | Lingwood; Clifford A. | Verotoxin pharmaceutical compositions and medical treatments therewith |
| DE69638269D1 (de) | 1995-06-14 | 2010-11-18 | Univ California | Hochaffine humane antikörper gegen tumorantigene |
| EP0929679A2 (en) * | 1996-09-10 | 1999-07-21 | Henry M. Jackson Foundation For The Advancement Of Military Medicine | Histidine-tagged shiga toxins, toxoids, and protein fusions with such toxins and toxoids, methods for the purification and preparation thereof |
| WO1998020903A1 (en) | 1996-11-15 | 1998-05-22 | Trustees Of Tufts College | Humanized neutralizing antibodies against hemolytic uremic syndrome |
| US20020160005A1 (en) | 1996-11-15 | 2002-10-31 | Trustees Of Tufts College | Human neutralizing antibodies against hemolytic urmec syndrome |
| US7910096B2 (en) | 1996-11-15 | 2011-03-22 | Trustees Of Tufts College | Human neutralizing antibodies against hemolytic uremic syndrome |
| US20030170248A1 (en) * | 1997-12-23 | 2003-09-11 | Jeffrey R. Stinson | Humanized monoclonal antibodies that protect against shiga toxin induced disease |
| DE69932719T2 (de) | 1998-05-20 | 2007-09-13 | Teijin Ltd. | Humanisierte Antikörper zur Erkennung von Verotoxin II sowie Zelllinie zur Herstellung derselben |
| EP1127263A1 (en) * | 1998-10-30 | 2001-08-29 | Photonic Sensor Systems | Methods and sensors for detecting or measuring an acid or base |
| US6833268B1 (en) | 1999-06-10 | 2004-12-21 | Abgenix, Inc. | Transgenic animals for producing specific isotypes of human antibodies via non-cognate switch regions |
| US7807184B2 (en) | 2003-07-21 | 2010-10-05 | Interuet International B.V. | Hybrid Shiga-like toxin |
| WO2005052158A1 (en) | 2003-11-28 | 2005-06-09 | National Research Council Of Canada | Anticarcinoma antibidies and uses thereof |
| US20050226883A1 (en) | 2004-02-06 | 2005-10-13 | Paul Averback | Humanized antibody |
| WO2007098201A2 (en) | 2006-02-16 | 2007-08-30 | The Henry M. Jackson Foundation For The Advancement Of Military Medicine, Inc. | Shiga toxoid chimeric proteins |
| WO2007124133A2 (en) | 2006-04-20 | 2007-11-01 | The Henry M. Jackson Foundation For The Advancement Of Military Medicine Incorporated | Methods and compositions based on shiga toxin type 1 protein |
| US20090258010A1 (en) | 2006-05-31 | 2009-10-15 | Thallion Pharmaceuticals, Inc. | Methods, compositions, and kits for treating shiga toxin associated conditions |
| EP2097529A4 (en) | 2006-12-29 | 2010-03-24 | Osprey Pharmaceuticals Usa Inc | METHOD FOR SELECTION AND PRODUCTION OF MODIFIED TOXINS, MODIFIED TOXINE CONJUGATES AND USES THEREOF |
| JP5773886B2 (ja) | 2009-01-23 | 2015-09-02 | ザ ヘンリー エム． ジャクソン ファウンデーション フォー ザ アドヴァンスメント オブ ミリタリー メディシン インコーポレイテッド | 志賀毒素タイプ２タンパク質に基づいた方法と組成物 |
-
2007
- 2007-04-20 WO PCT/US2007/009799 patent/WO2007124133A2/en not_active Ceased
- 2007-04-20 US US11/788,546 patent/US8293245B2/en active Active
- 2007-04-20 EP EP11179552A patent/EP2420246A1/en not_active Withdrawn
- 2007-04-20 EP EP07775978A patent/EP2019684A4/en not_active Withdrawn
- 2007-04-20 CA CA002646319A patent/CA2646319A1/en not_active Abandoned
- 2007-04-20 AU AU2007240614A patent/AU2007240614B2/en not_active Ceased
- 2007-04-20 MX MX2008013363A patent/MX2008013363A/es not_active Application Discontinuation
- 2007-04-20 JP JP2009506629A patent/JP2009536818A/ja active Pending
-
2012
- 2012-10-05 US US13/645,928 patent/US20130101591A1/en not_active Abandoned
-
2013
- 2013-10-02 US US14/044,580 patent/US20140023652A1/en not_active Abandoned
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