CN114729033A - 抗α-溶血素的抗体及其应用 - Google Patents
抗α-溶血素的抗体及其应用 Download PDFInfo
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- CN114729033A CN114729033A CN202080079468.8A CN202080079468A CN114729033A CN 114729033 A CN114729033 A CN 114729033A CN 202080079468 A CN202080079468 A CN 202080079468A CN 114729033 A CN114729033 A CN 114729033A
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Abstract
提供了一种结合金黄色葡萄球菌α‑溶血素的抗体或其片段，以及所述抗体或其片段用于预防或治疗金黄色葡萄球菌感染的用途。所述抗体通过α‑溶血素的弱毒免疫、强毒筛选的策略筛选得到，对α‑溶血素具有高亲和力，能够有效阻断α‑溶血素的溶血作用，且在α‑溶血素脓毒症模型、MRSA菌血症模型和MRSA肺部感染模型中均证明了显著的保护或治疗作用，且与抗生素具有协同作用，是对金黄色葡萄球菌现有抗生素疗法的有利补充。
Description
PCT国内申请，说明书已公开。
Claims (22)
- PCT国内申请，权利要求书已公开。
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| CN201910889697.5A CN112538112B (zh) | 2019-09-20 | 2019-09-20 | 抗α-溶血素的抗体及其应用 |
| CN2019108896975 | 2019-09-20 | ||
| PCT/CN2020/116184 WO2021052461A1 (zh) | 2019-09-20 | 2020-09-18 | 抗α-溶血素的抗体及其应用 |
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| CA (1) | CA3151773A1 (zh) |
| TW (1) | TW202126684A (zh) |
| WO (1) | WO2021052461A1 (zh) |
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| CN116789814A (zh) * | 2023-06-27 | 2023-09-22 | 重庆原伦生物科技有限公司 | 一种特异性结合金黄色葡萄球菌α-溶血素的抗体及其应用 |
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| WO2021233408A1 (zh) * | 2020-05-21 | 2021-11-25 | 迈威(上海)生物科技股份有限公司 | 抗α-溶血素的抗体及其稳定制剂 |
| WO2023208123A1 (zh) * | 2022-04-28 | 2023-11-02 | 珠海泰诺麦博制药股份有限公司 | 特异性结合金黄色葡萄球菌Hla毒素的全人源单克隆抗体 |
| CN117126282B (zh) * | 2023-10-26 | 2024-01-12 | 迈威(上海)生物科技股份有限公司 | 抗体及其在制备阻断αvβ8与Latent TGF-β的结合的药物中的应用 |
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|---|---|---|---|---|
| CN116789814A (zh) * | 2023-06-27 | 2023-09-22 | 重庆原伦生物科技有限公司 | 一种特异性结合金黄色葡萄球菌α-溶血素的抗体及其应用 |
| CN116789814B (zh) * | 2023-06-27 | 2024-03-29 | 重庆原伦生物科技有限公司 | 一种特异性结合金黄色葡萄球菌α-溶血素的抗体及其应用 |
Also Published As
| Publication number | Publication date |
|---|---|
| CA3151773A1 (en) | 2021-03-25 |
| WO2021052461A1 (zh) | 2021-03-25 |
| CN114729033B (zh) | 2023-11-28 |
| CN112538112B (zh) | 2023-10-27 |
| TW202126684A (zh) | 2021-07-16 |
| US20220324949A1 (en) | 2022-10-13 |
| AU2020348817A1 (en) | 2022-04-21 |
| EP4032904A1 (en) | 2022-07-27 |
| CN112538112A (zh) | 2021-03-23 |
| JP2022548937A (ja) | 2022-11-22 |
| EP4032904A4 (en) | 2024-01-24 |
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