CA2642451C - Shiga toxoid chimeric proteins - Google Patents
Shiga toxoid chimeric proteins Download PDFInfo
- Publication number
- CA2642451C CA2642451C CA2642451A CA2642451A CA2642451C CA 2642451 C CA2642451 C CA 2642451C CA 2642451 A CA2642451 A CA 2642451A CA 2642451 A CA2642451 A CA 2642451A CA 2642451 C CA2642451 C CA 2642451C
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- Prior art keywords
- toxoid
- shiga
- chimeric protein
- stxa2
- chimeric
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- Zoology (AREA)
- Microbiology (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
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- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
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- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US77365806P | 2006-02-16 | 2006-02-16 | |
| US60/773,658 | 2006-02-16 | ||
| PCT/US2007/004513 WO2007098201A2 (en) | 2006-02-16 | 2007-02-16 | Shiga toxoid chimeric proteins |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2642451A1 CA2642451A1 (en) | 2007-08-30 |
| CA2642451C true CA2642451C (en) | 2016-12-20 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2642451A Expired - Fee Related CA2642451C (en) | 2006-02-16 | 2007-02-16 | Shiga toxoid chimeric proteins |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US8846058B2 (enExample) |
| EP (1) | EP1991565B1 (enExample) |
| JP (1) | JP5409014B2 (enExample) |
| CA (1) | CA2642451C (enExample) |
| ES (1) | ES2532985T3 (enExample) |
| WO (1) | WO2007098201A2 (enExample) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20030170248A1 (en) * | 1997-12-23 | 2003-09-11 | Jeffrey R. Stinson | Humanized monoclonal antibodies that protect against shiga toxin induced disease |
| EP1229045A1 (en) * | 2001-02-01 | 2002-08-07 | Institut Curie | Universal carrier for targeting molecules to Gb3 receptor expressing cells |
| EP2420246A1 (en) * | 2006-04-20 | 2012-02-22 | The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc. | Methods and compositions based on shiga toxin type 1 protein |
| US20090258010A1 (en) * | 2006-05-31 | 2009-10-15 | Thallion Pharmaceuticals, Inc. | Methods, compositions, and kits for treating shiga toxin associated conditions |
| AU2007254950A1 (en) * | 2006-05-31 | 2007-12-13 | Thallion Pharmaceuticals Incorporated | Methods, compositions, and kits for treating Shiga toxin associated conditions |
| EP2207793A2 (en) * | 2007-10-08 | 2010-07-21 | Rutgers, The State University | Nontoxic shiga-like toxin mutant compositions and methods |
| ES2614803T3 (es) * | 2009-01-23 | 2017-06-02 | The Henry M. Jackson Foundation For The Advancement Of Military Medicine, Inc. | Métodos y composiciones basadas en proteína tipo 2 de la toxina Shiga |
| CN101948546B (zh) * | 2010-09-25 | 2012-11-07 | 中国人民解放军军事医学科学院微生物流行病研究所 | 融合蛋白SAmB及其编码基因与应用 |
| EP3453770B1 (en) * | 2012-02-24 | 2021-04-21 | Gen-Probe Prodesse, Inc. | Detection of shiga toxin genes in bacteria |
| US9310368B1 (en) * | 2012-09-28 | 2016-04-12 | The United States Of America, As Represented By The Secretary Of Agriculture | High affinity monoclonal antibodies for detection of Shiga toxin 2 (STX2) |
| US9513287B1 (en) * | 2012-09-28 | 2016-12-06 | The United States Of America, As Represented By The Secretary Of Agriculture | High affinity monoclonal antibodies for detection of shiga toxin 2 |
| RU2573924C2 (ru) * | 2013-07-11 | 2016-01-27 | Федеральное Государственное Бюджетное Учреждение Науки Институт Молекулярной Биологии Им. В.А. Энгельгардта Российской Академии Наук (Имб Ран) | НЕТОКСИЧНЫЙ РЕКОМБИНАНТНЫЙ ШИГА ТОКСИН 2-ГО ТИПА (Stx2) |
| CN112851769A (zh) | 2014-01-27 | 2021-05-28 | 分子模板公司 | 用于哺乳动物中的去免疫化志贺毒素a亚基效应子多肽 |
| US11142584B2 (en) | 2014-03-11 | 2021-10-12 | Molecular Templates, Inc. | CD20-binding proteins comprising Shiga toxin A subunit effector regions for inducing cellular internalization and methods using same |
| CN113831416A (zh) | 2014-06-11 | 2021-12-24 | 分子模板公司 | 耐受蛋白酶切割的志贺毒素a亚基效应子多肽和包含其的细胞靶向分子 |
| KR20170110601A (ko) | 2015-02-05 | 2017-10-11 | 몰레큘러 템플레이츠, 인코퍼레이션. | 시가 독소 a 서브유닛 작동체 영역을 포함하는 다가 cd20 결합 분자 및 이들의 강화된 조성물 |
| MX2017015493A (es) | 2015-05-30 | 2018-02-09 | Molecular Templates Inc | Andamiajes de la subunidad a de la toxina shiga desinmunizados y moleculas con direccion a las celulas que los comprenden. |
| KR102557126B1 (ko) | 2016-12-07 | 2023-07-18 | 몰레큘러 템플레이츠, 인코퍼레이션. | 부위 특이적 접합을 위한 시가 독소 a 서브유닛 작동체 폴리펩타이드, 시가 독소 작동체 스캐폴드, 및 세포-표적화 분자 |
| EP3559239B1 (en) | 2016-12-22 | 2024-09-25 | Leibniz-Institut für Pflanzengenetik und Kulturpflanzenforschung (IPK) | Oligomeric vaccines from plants by s-tag-s-protein fusions |
| ES2971981T3 (es) | 2017-01-25 | 2024-06-10 | Molecular Templates Inc | Moléculas de reconocimiento de células que comprenden efectores de la subunidad A de la toxina Shiga desinmunizados y epítopos de células T CD8+ |
| CN110612117B (zh) | 2018-04-17 | 2024-04-12 | 分子模板公司 | 包含去免疫化的志贺毒素a亚基支架的her2靶向分子 |
| CN111333734B (zh) * | 2020-03-31 | 2022-05-03 | 中国人民解放军军事科学院军事医学研究院 | 一种百日咳丝状血凝素融合蛋白及其应用 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5552144A (en) * | 1992-01-22 | 1996-09-03 | Microcarb, Inc. | Immunogenic shiga-like toxin II variant mutants |
| WO1998011229A2 (en) | 1996-09-10 | 1998-03-19 | Henry M. Jackson Foundation For The Advancement Of Military Medicine | Histidine-tagged shiga toxins, toxoids, and protein fusions with such toxins and toxoids, methods for the purification and preparation thereof |
-
2007
- 2007-02-16 EP EP07751283.8A patent/EP1991565B1/en not_active Not-in-force
- 2007-02-16 ES ES07751283.8T patent/ES2532985T3/es active Active
- 2007-02-16 WO PCT/US2007/004513 patent/WO2007098201A2/en not_active Ceased
- 2007-02-16 JP JP2008555421A patent/JP5409014B2/ja not_active Expired - Fee Related
- 2007-02-16 CA CA2642451A patent/CA2642451C/en not_active Expired - Fee Related
- 2007-02-16 US US12/279,423 patent/US8846058B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| US8846058B2 (en) | 2014-09-30 |
| CA2642451A1 (en) | 2007-08-30 |
| EP1991565A4 (en) | 2009-12-09 |
| JP5409014B2 (ja) | 2014-02-05 |
| WO2007098201A2 (en) | 2007-08-30 |
| AU2007217782A1 (en) | 2007-08-30 |
| ES2532985T3 (es) | 2015-04-06 |
| WO2007098201A3 (en) | 2009-04-16 |
| EP1991565A2 (en) | 2008-11-19 |
| EP1991565B1 (en) | 2015-01-21 |
| US20090226469A1 (en) | 2009-09-10 |
| JP2009527226A (ja) | 2009-07-30 |
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| EEER | Examination request | ||
| MKLA | Lapsed |
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