JP2019520083A5 - - Google Patents
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- JP2019520083A5 JP2019520083A5 JP2019500781A JP2019500781A JP2019520083A5 JP 2019520083 A5 JP2019520083 A5 JP 2019520083A5 JP 2019500781 A JP2019500781 A JP 2019500781A JP 2019500781 A JP2019500781 A JP 2019500781A JP 2019520083 A5 JP2019520083 A5 JP 2019520083A5
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- JP
- Japan
- Prior art keywords
- substitution
- seq
- position corresponding
- polypeptide
- amino acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 238000006467 substitution reaction Methods 0.000 claims description 292
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 165
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 165
- 229920001184 polypeptide Polymers 0.000 claims description 163
- 125000003275 alpha amino acid group Chemical group 0.000 claims description 76
- 235000001014 amino acid Nutrition 0.000 claims description 64
- 238000012217 deletion Methods 0.000 claims description 64
- 230000037430 deletion Effects 0.000 claims description 64
- 239000000203 mixture Substances 0.000 claims description 35
- 125000001554 selenocysteine group Chemical group [H][Se]C([H])([H])C(N([H])[H])C(=O)O* 0.000 claims description 31
- 150000007523 nucleic acids Chemical class 0.000 claims description 20
- 108020004707 nucleic acids Proteins 0.000 claims description 19
- 102000039446 nucleic acids Human genes 0.000 claims description 19
- 241000894006 Bacteria Species 0.000 claims description 6
- 238000000034 method Methods 0.000 claims description 6
- 108090000790 Enzymes Proteins 0.000 claims description 5
- 102000004190 Enzymes Human genes 0.000 claims description 5
- 241000588724 Escherichia coli Species 0.000 claims description 4
- BUGBHKTXTAQXES-UHFFFAOYSA-N Selenium Chemical compound [Se] BUGBHKTXTAQXES-UHFFFAOYSA-N 0.000 claims description 3
- 201000010099 disease Diseases 0.000 claims description 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 3
- 239000008194 pharmaceutical composition Substances 0.000 claims description 3
- 229910052711 selenium Inorganic materials 0.000 claims description 3
- 239000011669 selenium Substances 0.000 claims description 3
- FDKWRPBBCBCIGA-REOHCLBHSA-N (2r)-2-azaniumyl-3-$l^{1}-selanylpropanoate Chemical compound [Se]C[C@H](N)C(O)=O FDKWRPBBCBCIGA-REOHCLBHSA-N 0.000 claims 1
- FDKWRPBBCBCIGA-UWTATZPHSA-N D-Selenocysteine Natural products [Se]C[C@@H](N)C(O)=O FDKWRPBBCBCIGA-UWTATZPHSA-N 0.000 claims 1
- 230000001580 bacterial effect Effects 0.000 claims 1
- ZKZBPNGNEQAJSX-UHFFFAOYSA-N selenocysteine Natural products [SeH]CC(N)C(O)=O ZKZBPNGNEQAJSX-UHFFFAOYSA-N 0.000 claims 1
- 235000016491 selenocysteine Nutrition 0.000 claims 1
- 229940055619 selenocysteine Drugs 0.000 claims 1
- 101710137500 T7 RNA polymerase Proteins 0.000 description 2
- 108091026890 Coding region Proteins 0.000 description 1
- 108091028043 Nucleic acid sequence Proteins 0.000 description 1
- 108020005038 Terminator Codon Proteins 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 230000014425 selenocysteine incorporation Effects 0.000 description 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2023029563A JP2023060001A (ja) | 2016-07-11 | 2023-02-28 | セレノシステインを含む組換えポリペプチド及びその製造方法 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662360745P | 2016-07-11 | 2016-07-11 | |
| US62/360,745 | 2016-07-11 | ||
| PCT/US2017/041373 WO2018013481A1 (en) | 2016-07-11 | 2017-07-10 | Recombinant polypeptides comprising selenocysteine and method for producing the same |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023029563A Division JP2023060001A (ja) | 2016-07-11 | 2023-02-28 | セレノシステインを含む組換えポリペプチド及びその製造方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019520083A JP2019520083A (ja) | 2019-07-18 |
| JP2019520083A5 true JP2019520083A5 (enExample) | 2020-08-20 |
| JP7269648B2 JP7269648B2 (ja) | 2023-05-09 |
Family
ID=60953318
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019500781A Active JP7269648B2 (ja) | 2016-07-11 | 2017-07-10 | セレノシステインを含む組換えポリペプチド及びその製造方法 |
| JP2023029563A Withdrawn JP2023060001A (ja) | 2016-07-11 | 2023-02-28 | セレノシステインを含む組換えポリペプチド及びその製造方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023029563A Withdrawn JP2023060001A (ja) | 2016-07-11 | 2023-02-28 | セレノシステインを含む組換えポリペプチド及びその製造方法 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US11155804B2 (enExample) |
| EP (1) | EP3481945A4 (enExample) |
| JP (2) | JP7269648B2 (enExample) |
| CN (1) | CN109844105A (enExample) |
| CA (1) | CA3030163A1 (enExample) |
| WO (1) | WO2018013481A1 (enExample) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA3034701A1 (en) | 2016-08-30 | 2018-03-08 | Board Of Regents, The University Of Texas System | Production of seleno-biologics in genomically recoded organisms |
| CN109486802B (zh) * | 2018-12-26 | 2020-08-04 | 广州白云山拜迪生物医药有限公司 | 一种酶活提高的青霉素酶突变体及其构建方法 |
| WO2025024577A1 (en) * | 2023-07-24 | 2025-01-30 | Board Of Regents, The University Of Texas System | Incorporating unnatural amino acids using one pot pure system |
| CN120158456A (zh) * | 2023-10-18 | 2025-06-17 | 河南农业大学 | 玉米ZmmtRF2a基因突变标记、鉴定引物及其在调控籽粒发育中的应用 |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH10309193A (ja) | 1997-05-12 | 1998-11-24 | Sankyo Co Ltd | 哺乳類セレノシステイン含有タンパク質の大腸菌での製造法 |
| US6849417B1 (en) | 1998-04-06 | 2005-02-01 | The United States Of America As Represented By The Department Of Health And Human Services | Mammalian selenoprotein differentially expressed in tumor cells |
| AU6987200A (en) * | 1999-08-16 | 2001-03-13 | Karolinska Innovations Ab | Methods and means for selenoprotein expression |
| US20060051851A1 (en) | 2001-09-13 | 2006-03-09 | Sara Kaminaka | Novel selenocysteine-containing protein |
| WO2007075438A2 (en) | 2005-12-15 | 2007-07-05 | Codon Devices, Inc. | Polypeptides comprising unnatural amino acids, methods for their production and uses therefor |
| CN101965363A (zh) | 2006-11-02 | 2011-02-02 | 丹尼尔·J·卡鹏 | 具有活动部分的杂合免疫球蛋白 |
| WO2009043051A2 (en) | 2007-09-27 | 2009-04-02 | Biogen Idec Ma Inc. | Cd23 binding molecules and methods of use thereof |
| KR101656107B1 (ko) | 2007-11-20 | 2016-09-08 | 암브룩스, 인코포레이티드 | 변형된 인슐린 폴리펩티드 및 이의 용도 |
| MX2013008736A (es) | 2011-01-28 | 2013-11-22 | Ca Nat Research Council | Diseño de dominios de inmunoglobulina. |
| DK2717898T3 (en) * | 2011-06-10 | 2019-03-25 | Bioverativ Therapeutics Inc | COAGULATING COMPOUNDS AND PROCEDURES FOR USE THEREOF |
| US10240158B2 (en) | 2011-07-11 | 2019-03-26 | Yale University | Compositions and methods for making selenocysteine containing polypeptides |
| US9464288B2 (en) | 2011-07-11 | 2016-10-11 | Yale University | Compositions and methods for making selenocysteine containing polypeptides |
| US10876142B2 (en) | 2011-07-11 | 2020-12-29 | Yale University | Compositions and methods for making selenocysteine containing polypeptides |
| EP2968552B1 (en) | 2013-03-14 | 2020-03-11 | The Scripps Research Institute | Targeting agent antibody conjugates and uses thereof |
| US20150050682A1 (en) | 2013-08-15 | 2015-02-19 | University Of Vermont And State Agricultural College | Direct assay of thioredoxin reductase activity |
| WO2015066543A1 (en) | 2013-11-01 | 2015-05-07 | Board Of Regents, The University Of Texas System | Targeting her2 and her3 with bispecific antibodies in cancerous cells |
| US10118950B2 (en) | 2014-08-30 | 2018-11-06 | Northwestern University | Platforms for cell-free protein synthesis comprising extracts from genomically recoded E. coli strains having genetic knock-out mutations in release factor 1 (RF-1) and endA |
| WO2016172269A2 (en) | 2015-04-20 | 2016-10-27 | University Of Utah Research Foundation | Insulin analogs having shortened b chain peptides and associated methods |
| US10557160B2 (en) | 2015-12-15 | 2020-02-11 | Board Of Regents, The University Of Texas System | Transgenic bacteria with expanded amino acid usage and nucleic acid molecules for use in the same |
| AU2017298565B2 (en) | 2016-07-22 | 2021-08-19 | The Walter And Eliza Hall Institute Of Medical Research | Insulin analogs |
| CA3034701A1 (en) | 2016-08-30 | 2018-03-08 | Board Of Regents, The University Of Texas System | Production of seleno-biologics in genomically recoded organisms |
-
2017
- 2017-07-10 CN CN201780048121.5A patent/CN109844105A/zh active Pending
- 2017-07-10 US US16/316,768 patent/US11155804B2/en active Active
- 2017-07-10 WO PCT/US2017/041373 patent/WO2018013481A1/en not_active Ceased
- 2017-07-10 EP EP17828247.1A patent/EP3481945A4/en active Pending
- 2017-07-10 JP JP2019500781A patent/JP7269648B2/ja active Active
- 2017-07-10 CA CA3030163A patent/CA3030163A1/en active Pending
-
2023
- 2023-02-28 JP JP2023029563A patent/JP2023060001A/ja not_active Withdrawn
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