JP2005120106A5 - - Google Patents
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- Publication number
- JP2005120106A5 JP2005120106A5 JP2004363734A JP2004363734A JP2005120106A5 JP 2005120106 A5 JP2005120106 A5 JP 2005120106A5 JP 2004363734 A JP2004363734 A JP 2004363734A JP 2004363734 A JP2004363734 A JP 2004363734A JP 2005120106 A5 JP2005120106 A5 JP 2005120106A5
- Authority
- JP
- Japan
- Prior art keywords
- polypeptide
- seq
- antigenic
- host cell
- amino acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 229920001184 polypeptide Polymers 0.000 claims 10
- 102000004196 processed proteins & peptides Human genes 0.000 claims 10
- 108090000765 processed proteins & peptides Proteins 0.000 claims 10
- 230000000890 antigenic effect Effects 0.000 claims 3
- 125000000539 amino acid group Chemical group 0.000 claims 2
- 102000039446 nucleic acids Human genes 0.000 claims 2
- 108020004707 nucleic acids Proteins 0.000 claims 2
- 150000007523 nucleic acids Chemical class 0.000 claims 2
- 102000008394 Immunoglobulin Fragments Human genes 0.000 claims 1
- 108010021625 Immunoglobulin Fragments Proteins 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 239000013604 expression vector Substances 0.000 claims 1
- 108020001507 fusion proteins Proteins 0.000 claims 1
- 102000037865 fusion proteins Human genes 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 239000013598 vector Substances 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US4429397P | 1997-05-07 | 1997-05-07 | |
| US7221298P | 1998-01-22 | 1998-01-22 | |
| US7694798P | 1998-03-05 | 1998-03-05 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP54829998A Division JP2002514083A (ja) | 1997-05-07 | 1998-05-07 | ヒトＴｏｌｌ様レセプタータンパク質、関連する試薬および方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2005120106A JP2005120106A (ja) | 2005-05-12 |
| JP2005120106A5 true JP2005120106A5 (enExample) | 2005-09-02 |
Family
ID=27366459
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP54829998A Withdrawn JP2002514083A (ja) | 1997-05-07 | 1998-05-07 | ヒトＴｏｌｌ様レセプタータンパク質、関連する試薬および方法 |
| JP2004363734A Withdrawn JP2005120106A (ja) | 1997-05-07 | 2004-12-15 | ヒトＴｏｌｌ様レセプタータンパク質、関連する試薬および方法 |
| JP2005307907A Pending JP2006052232A (ja) | 1997-05-07 | 2005-10-21 | ヒトＴｏｌｌ様レセプタータンパク質、関連する試薬および方法 |
| JP2008326610A Withdrawn JP2009089713A (ja) | 1997-05-07 | 2008-12-22 | ヒトＴｏｌｌ様レセプタータンパク質、関連する試薬および方法 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP54829998A Withdrawn JP2002514083A (ja) | 1997-05-07 | 1998-05-07 | ヒトＴｏｌｌ様レセプタータンパク質、関連する試薬および方法 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2005307907A Pending JP2006052232A (ja) | 1997-05-07 | 2005-10-21 | ヒトＴｏｌｌ様レセプタータンパク質、関連する試薬および方法 |
| JP2008326610A Withdrawn JP2009089713A (ja) | 1997-05-07 | 2008-12-22 | ヒトＴｏｌｌ様レセプタータンパク質、関連する試薬および方法 |
Country Status (19)
| Country | Link |
|---|---|
| EP (4) | EP1988166A1 (enExample) |
| JP (4) | JP2002514083A (enExample) |
| KR (1) | KR100388860B1 (enExample) |
| CN (4) | CN1225555C (enExample) |
| AT (3) | ATE443139T1 (enExample) |
| AU (1) | AU740333B2 (enExample) |
| CA (1) | CA2289912C (enExample) |
| CY (1) | CY1109645T1 (enExample) |
| DE (3) | DE69836630T2 (enExample) |
| DK (2) | DK1798288T3 (enExample) |
| ES (3) | ES2340210T3 (enExample) |
| ID (1) | ID28299A (enExample) |
| IL (1) | IL132614A0 (enExample) |
| NO (1) | NO995458L (enExample) |
| NZ (1) | NZ338073A (enExample) |
| PL (1) | PL336635A1 (enExample) |
| PT (1) | PT1798288E (enExample) |
| SK (1) | SK146599A3 (enExample) |
| WO (1) | WO1998050547A2 (enExample) |
Families Citing this family (64)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6812327B1 (en) | 1996-10-25 | 2004-11-02 | Human Genome Sciences, Inc. | Neutrokine-alpha polypeptides |
| US8212004B2 (en) | 1999-03-02 | 2012-07-03 | Human Genome Sciences, Inc. | Neutrokine-alpha fusion proteins |
| US7696327B1 (en) | 1997-10-17 | 2010-04-13 | Genentech, Inc. | Antibodies to human Toll homologues |
| US20030032090A1 (en) | 1997-05-07 | 2003-02-13 | Schering Corporation, A New Jersey Corporation | Human receptor proteins; related reagents and methods |
| EP1650219B1 (en) * | 1997-10-17 | 2007-12-19 | Genentech, Inc. | Human toll homologues |
| AU2003203679B2 (en) * | 1997-10-17 | 2007-04-05 | Genentech, Inc. | Human toll homologues |
| JP2000128900A (ja) * | 1998-10-26 | 2000-05-09 | Japan Science & Technology Corp | 新規トル様（Ｔｏｌｌ−ｌｉｋｅ）レセプター及びその遺伝子 |
| US6303321B1 (en) | 1999-02-11 | 2001-10-16 | North Shore-Long Island Jewish Research Institute | Methods for diagnosing sepsis |
| US6740487B1 (en) * | 1999-06-10 | 2004-05-25 | University Of Iowa Research Foundation | Variant TLR4 nucleic acid and uses thereof |
| DE60041452D1 (de) * | 1999-11-02 | 2009-03-12 | Novartis Vaccines & Diagnostic | CpG REZEPTOR (CpG-R) UND DARAUF BEZOGENE METHODEN |
| GB9927332D0 (en) * | 1999-11-18 | 2000-01-12 | Leiv Eiriksson Nyfotek As | Novel antibody and uses thereof |
| GB0001704D0 (en) * | 2000-01-25 | 2000-03-15 | Glaxo Group Ltd | Protein |
| US20030083244A1 (en) * | 2000-04-26 | 2003-05-01 | Vernet Corine A.M. | Novel proteins and nucleic acids encoding same |
| HUP0302240A2 (hu) * | 2000-05-25 | 2003-10-28 | Schering Corp. | Humán receptorfehérjék, ezekkel kapcsolatos reagensek és eljárások |
| US7879328B2 (en) | 2000-06-16 | 2011-02-01 | Human Genome Sciences, Inc. | Antibodies that immunospecifically bind to B lymphocyte stimulator |
| AU2001268427B2 (en) | 2000-06-16 | 2007-03-29 | Glaxosmithkline Intellectual Property Limited | Antibodies that immunospecifically bind to blys |
| JP2002034565A (ja) * | 2000-07-19 | 2002-02-05 | Japan Science & Technology Corp | 細菌ｄｎａを特異的に認識する受容体タンパク質 |
| AU2001288301A1 (en) | 2000-08-18 | 2002-03-04 | Human Genome Sciences, Inc. | Binding polypeptides and methods based thereon |
| AU2001285066B2 (en) * | 2000-08-18 | 2006-06-29 | Human Genome Sciences, Inc. | Binding polypeptides for B lymphocyte stimulator protein (BLYS) |
| JP2005500806A (ja) | 2000-09-15 | 2005-01-13 | コーリー ファーマシューティカル ゲーエムベーハー | ＣｐＧに基づく免疫アゴニスト／免疫アンタゴニストの高スループットスクリーニングのためのプロセス |
| US7220723B2 (en) | 2001-05-15 | 2007-05-22 | The Feinstein Institute For Medical Research | Inhibitors of the interaction between HMGB polypeptides and toll-like receptor 2 as anti-inflammatory agents |
| US7304034B2 (en) | 2001-05-15 | 2007-12-04 | The Feinstein Institute For Medical Research | Use of HMGB fragments as anti-inflammatory agents |
| EP1451581A4 (en) * | 2001-10-05 | 2006-01-11 | Coley Pharm Gmbh | AGONISTS AND ANTAGONISTS OF THE SIGNALING OF THE GREAT-SIMILAR RECEPTOR 3 |
| DE60230340D1 (de) * | 2001-11-16 | 2009-01-22 | 3M Innovative Properties Co | N-Ä4-(4-Amino-2-ethyl-1H-imidazoÄ4,5-cÜchinolin-1-yl)butylÜmethanesulfonamide, diese enthaltende pharmazeutische Zusammensetzung und deren Verwendung |
| GB0127618D0 (en) * | 2001-11-17 | 2002-01-09 | Univ Nottingham | "Composition and method for treatment of wounds" |
| JP2004016021A (ja) | 2002-06-12 | 2004-01-22 | Japan Science & Technology Corp | 抗体および阻害剤並びにそれを用いた形質転換方法および形質転換キット |
| WO2004053452A2 (en) * | 2002-12-11 | 2004-06-24 | 3M Innovative Properties Company | Assays relating to toll-like receptor activity |
| WO2004094671A2 (en) * | 2003-04-22 | 2004-11-04 | Coley Pharmaceutical Gmbh | Methods and products for identification and assessment of tlr ligands |
| US7696169B2 (en) | 2003-06-06 | 2010-04-13 | The Feinstein Institute For Medical Research | Inhibitors of the interaction between HMGB polypeptides and toll-like receptor 2 as anti-inflammatory agents |
| EP1668035A2 (en) | 2003-09-11 | 2006-06-14 | Critical Therapeutics, Inc. | Monoclonal antibodies against hmgb1 |
| EP1673087B1 (en) | 2003-10-03 | 2015-05-13 | 3M Innovative Properties Company | Alkoxy substituted imidazoquinolines |
| TW200516153A (en) * | 2003-10-03 | 2005-05-16 | Hitachi Chemical Co Ltd | Human toll-like receptor 3 gene polymorphism as marker for inherited factor of allergic disease and utilization of the same |
| TW200514850A (en) * | 2003-10-03 | 2005-05-01 | Hitachi Chemical Co Ltd | Method of evaluating risk for viral infection |
| JP2007514648A (ja) | 2003-10-24 | 2007-06-07 | エーザイ株式会社 | Ｔｏｌｌ−ｌｉｋｅｒｅｃｅｐｔｏｒ２に関連する疾患及び状態を治療するための化合物及び方法 |
| AU2004293078B2 (en) | 2003-11-25 | 2012-01-19 | 3M Innovative Properties Company | Substituted imidazo ring systems and methods |
| JP2008022701A (ja) * | 2004-09-24 | 2008-02-07 | Japan Science & Technology Agency | 可溶型Ｔｏｌｌ様受容体４タンパク質 |
| CA2587676A1 (en) | 2004-11-19 | 2006-05-26 | Institut Gustave Roussy | Improved treatment of cancer by double-stranded rna |
| AR051836A1 (es) | 2004-11-30 | 2007-02-14 | Centocor Inc | Antagonistas de receptor 3 simil toll metodos y usos |
| JP2008530022A (ja) | 2005-02-04 | 2008-08-07 | コーリー ファーマシューティカル グループ，インコーポレイテッド | 免疫反応調節物質を含む水性ゲル処方物 |
| US7700728B2 (en) | 2005-03-24 | 2010-04-20 | Schering Corporation | Use of chimeric receptors in a screening assay for identifying agonists and antagonists of cell receptors |
| US7498409B2 (en) | 2005-03-24 | 2009-03-03 | Schering Corporation | Screening assay for TLR7, TLR8 and TLR9 agonists and antagonists |
| US9168286B2 (en) | 2005-10-13 | 2015-10-27 | Human Genome Sciences, Inc. | Methods and compositions for use in treatment of patients with autoantibody positive disease |
| JP5199878B2 (ja) | 2005-10-27 | 2013-05-15 | セントカー・インコーポレーテツド | Ｔｏｌｌ様受容体３モジュレーター、方法および用途 |
| ES2555544T3 (es) | 2006-03-07 | 2016-01-04 | Vaxinnate Corporation | Composiciones que incluyen hemaglutinina, métodos de preparación y métodos de uso de las mismas |
| WO2007123765A2 (en) | 2006-03-31 | 2007-11-01 | Human Genome Sciences Inc. | Neutrokine-alpha and neutrokine-alpha splice variant |
| CN101134046B (zh) * | 2006-09-01 | 2011-10-05 | 中国医学科学院药物研究所 | Tlr4和tlr9激动剂复方在抑制肿瘤转移中的应用 |
| WO2008147956A2 (en) * | 2007-05-25 | 2008-12-04 | Centocor, Inc. | Toll-like receptor 3 modulators and uses thereof |
| EP2281043B1 (en) | 2008-04-25 | 2013-03-13 | Innate Pharma | Improved tlr3 agonist compositions |
| EP2116602A1 (en) | 2008-05-07 | 2009-11-11 | Institut Gustave Roussy | Combination products for treating cancer |
| WO2010031749A1 (en) | 2008-09-17 | 2010-03-25 | Innate Pharma | Compositions and methods for detecting tlr3 |
| US9512196B2 (en) | 2008-09-22 | 2016-12-06 | Cedars-Sinai Medical Center | Short-form human MD-2 as a negative regulator of toll-like receptor 4 signaling |
| EP2328911A4 (en) | 2008-09-22 | 2012-03-14 | Cedars Sinai Medical Center | SHORT HUMAN MD-2 AS A NEGATIVE REGULATOR OF GREAT LIKE RECEPTOR 4 SIGNALING |
| EP2451844B1 (en) | 2009-07-10 | 2015-04-22 | Innate Pharma | Tlr3 binding agents |
| JP5830744B2 (ja) * | 2009-08-19 | 2015-12-09 | 国立大学法人東京工業大学 | 乳酸菌の付着性を誘導するペプチド及びその用途 |
| WO2013054329A1 (en) * | 2011-10-10 | 2013-04-18 | Yeda Research And Development Co. Ltd. | Toll-like receptor 4 (tlr-4) agonist peptides for modulating tlr-4 mediated immune response |
| JP2013538558A (ja) | 2010-07-19 | 2013-10-17 | イエダ リサーチ アンド ディベロップメント カンパニー リミテッド | Ｔｌｒ媒介疾患を治療するためのｔｏｌｌ様受容体（ｔｌｒ）の膜貫通型ドメインに基づくペプチド |
| US9814740B2 (en) | 2010-12-21 | 2017-11-14 | Duke University | Methods and compositions combining immunotherapy with monocyte activation |
| EP2663329A2 (en) | 2011-01-12 | 2013-11-20 | Innate Pharma | Tlr3 binding agents |
| WO2012167053A1 (en) | 2011-06-01 | 2012-12-06 | Janus Biotherapeutics, Inc. | Novel immune system modulators |
| RU2606114C2 (ru) | 2011-06-01 | 2017-01-10 | Джейнус Байотерапьютикс, Инк. | Новые модуляторы иммунной системы |
| CA2850932A1 (en) | 2011-10-04 | 2013-04-11 | Janus Biotherapeutics, Inc. | Novel imidazole quinoline-based immune system modulators |
| WO2013178736A1 (en) | 2012-05-31 | 2013-12-05 | Innate Pharma | Tlr3 binding agents |
| US10017739B2 (en) | 2012-09-06 | 2018-07-10 | Duke University | Methods of expanding and assessing B cells and using expanded B cells to treat disease |
| CN113502299B (zh) * | 2021-07-20 | 2023-03-14 | 中国农业大学 | 一种抗金黄色葡萄球菌遗传修饰山羊生产方法 |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3645090A (en) | 1969-06-19 | 1972-02-29 | Citizen Watch Co Ltd | Day-date quick-adjuster for calender timepiece |
| US3940475A (en) | 1970-06-11 | 1976-02-24 | Biological Developments, Inc. | Radioimmune method of assaying quantitatively for a hapten |
| NL154598B (nl) | 1970-11-10 | 1977-09-15 | Organon Nv | Werkwijze voor het aantonen en bepalen van laagmoleculire verbindingen en van eiwitten die deze verbindingen specifiek kunnen binden, alsmede testverpakking. |
| US3817837A (en) | 1971-05-14 | 1974-06-18 | Syva Corp | Enzyme amplification assay |
| US3939350A (en) | 1974-04-29 | 1976-02-17 | Board Of Trustees Of The Leland Stanford Junior University | Fluorescent immunoassay employing total reflection for activation |
| US3996345A (en) | 1974-08-12 | 1976-12-07 | Syva Company | Fluorescence quenching with immunological pairs in immunoassays |
| US4277437A (en) | 1978-04-05 | 1981-07-07 | Syva Company | Kit for carrying out chemically induced fluorescence immunoassay |
| US4275149A (en) | 1978-11-24 | 1981-06-23 | Syva Company | Macromolecular environment control in specific receptor assays |
| US4366241A (en) | 1980-08-07 | 1982-12-28 | Syva Company | Concentrating zone method in heterogeneous immunoassays |
| US4659678A (en) | 1982-09-29 | 1987-04-21 | Serono Diagnostics Limited | Immunoassay of antigens |
| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| US4859609A (en) | 1986-04-30 | 1989-08-22 | Genentech, Inc. | Novel receptors for efficient determination of ligands and their antagonists or agonists |
| US5789192A (en) | 1992-12-10 | 1998-08-04 | Schering Corporation | Mammalian receptors for interleukin-10 (IL-10) |
| WO1998002557A2 (en) * | 1996-07-12 | 1998-01-22 | Schering Corporation | MAMMALIAN TNF-α CONVERTASES |
| DE69835751T2 (de) * | 1997-08-01 | 2007-10-04 | Serono Genetics Institute S.A. | 5' ests für proteine, die nicht gewebespezifisch sind |
| EP1650219B1 (en) * | 1997-10-17 | 2007-12-19 | Genentech, Inc. | Human toll homologues |
-
1998
- 1998-05-07 NZ NZ338073A patent/NZ338073A/en unknown
- 1998-05-07 ES ES07123073T patent/ES2340210T3/es not_active Expired - Lifetime
- 1998-05-07 AT AT06025414T patent/ATE443139T1/de active
- 1998-05-07 CA CA2289912A patent/CA2289912C/en not_active Expired - Fee Related
- 1998-05-07 DE DE69836630T patent/DE69836630T2/de not_active Revoked
- 1998-05-07 ES ES98918934T patent/ES2279572T3/es not_active Expired - Lifetime
- 1998-05-07 ES ES06025414T patent/ES2331622T3/es not_active Expired - Lifetime
- 1998-05-07 EP EP08104511A patent/EP1988166A1/en not_active Ceased
- 1998-05-07 DK DK06025414T patent/DK1798288T3/da active
- 1998-05-07 PL PL98336635A patent/PL336635A1/xx unknown
- 1998-05-07 AT AT07123073T patent/ATE458053T1/de not_active IP Right Cessation
- 1998-05-07 DE DE69841514T patent/DE69841514D1/de not_active Expired - Lifetime
- 1998-05-07 CN CNB988066408A patent/CN1225555C/zh not_active Expired - Fee Related
- 1998-05-07 PT PT06025414T patent/PT1798288E/pt unknown
- 1998-05-07 AT AT98918934T patent/ATE348157T1/de not_active IP Right Cessation
- 1998-05-07 EP EP06025414A patent/EP1798288B1/en not_active Expired - Lifetime
- 1998-05-07 EP EP07123073A patent/EP1925666B1/en not_active Expired - Lifetime
- 1998-05-07 AU AU71754/98A patent/AU740333B2/en not_active Ceased
- 1998-05-07 WO PCT/US1998/008979 patent/WO1998050547A2/en not_active Ceased
- 1998-05-07 KR KR10-1999-7010275A patent/KR100388860B1/ko not_active Expired - Fee Related
- 1998-05-07 CN CNA2006101002207A patent/CN1935840A/zh active Pending
- 1998-05-07 CN CNA2005100927155A patent/CN1800214A/zh active Pending
- 1998-05-07 SK SK1465-99A patent/SK146599A3/sk unknown
- 1998-05-07 DK DK98918934T patent/DK0980429T3/da active
- 1998-05-07 EP EP98918934A patent/EP0980429B1/en not_active Revoked
- 1998-05-07 JP JP54829998A patent/JP2002514083A/ja not_active Withdrawn
- 1998-05-07 DE DE69841170T patent/DE69841170D1/de not_active Expired - Lifetime
- 1998-05-07 CN CNA2008102136180A patent/CN101486759A/zh active Pending
- 1998-05-07 IL IL13261498A patent/IL132614A0/xx unknown
- 1998-07-05 ID IDW991326A patent/ID28299A/id unknown
-
1999
- 1999-11-08 NO NO995458A patent/NO995458L/no not_active Application Discontinuation
-
2004
- 2004-12-15 JP JP2004363734A patent/JP2005120106A/ja not_active Withdrawn
-
2005
- 2005-10-21 JP JP2005307907A patent/JP2006052232A/ja active Pending
-
2008
- 2008-12-22 JP JP2008326610A patent/JP2009089713A/ja not_active Withdrawn
-
2009
- 2009-11-25 CY CY20091101218T patent/CY1109645T1/el unknown