CY1109645T1 - Ανθρωπινος πρωτεϊνικος υποδοχεας τυπου toll, σχετικα αντιδραστηρια και μεθοδοι - Google Patents

Ανθρωπινος πρωτεϊνικος υποδοχεας τυπου toll, σχετικα αντιδραστηρια και μεθοδοι

Info

Publication number
CY1109645T1
CY1109645T1 CY20091101218T CY091101218T CY1109645T1 CY 1109645 T1 CY1109645 T1 CY 1109645T1 CY 20091101218 T CY20091101218 T CY 20091101218T CY 091101218 T CY091101218 T CY 091101218T CY 1109645 T1 CY1109645 T1 CY 1109645T1
Authority
CY
Cyprus
Prior art keywords
methods
type protein
protein receptor
related reagents
human toll
Prior art date
Application number
CY20091101218T
Other languages
Greek (el)
English (en)
Inventor
Gerard. T. HARDIMAN
J. Fernando Bazan
Fernando L. Rock
Robert A. Kastelein
Original Assignee
Schering Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27366459&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CY1109645(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Schering Corporation filed Critical Schering Corporation
Publication of CY1109645T1 publication Critical patent/CY1109645T1/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biomedical Technology (AREA)
  • Toxicology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
CY20091101218T 1997-05-07 2009-11-25 Ανθρωπινος πρωτεϊνικος υποδοχεας τυπου toll, σχετικα αντιδραστηρια και μεθοδοι CY1109645T1 (el)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US4429397P 1997-05-07 1997-05-07
US7221298P 1998-01-22 1998-01-22
US7694798P 1998-03-05 1998-03-05
EP98918934A EP0980429B1 (en) 1997-05-07 1998-05-07 Human toll-like receptor proteins, related reagents and methods

Publications (1)

Publication Number Publication Date
CY1109645T1 true CY1109645T1 (el) 2012-05-23

Family

ID=27366459

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20091101218T CY1109645T1 (el) 1997-05-07 2009-11-25 Ανθρωπινος πρωτεϊνικος υποδοχεας τυπου toll, σχετικα αντιδραστηρια και μεθοδοι

Country Status (19)

Country Link
EP (4) EP1798288B1 (enExample)
JP (4) JP2002514083A (enExample)
KR (1) KR100388860B1 (enExample)
CN (4) CN1225555C (enExample)
AT (3) ATE458053T1 (enExample)
AU (1) AU740333B2 (enExample)
CA (1) CA2289912C (enExample)
CY (1) CY1109645T1 (enExample)
DE (3) DE69841170D1 (enExample)
DK (2) DK0980429T3 (enExample)
ES (3) ES2340210T3 (enExample)
ID (1) ID28299A (enExample)
IL (1) IL132614A0 (enExample)
NO (1) NO995458L (enExample)
NZ (1) NZ338073A (enExample)
PL (1) PL336635A1 (enExample)
PT (1) PT1798288E (enExample)
SK (1) SK146599A3 (enExample)
WO (1) WO1998050547A2 (enExample)

Families Citing this family (64)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6812327B1 (en) 1996-10-25 2004-11-02 Human Genome Sciences, Inc. Neutrokine-alpha polypeptides
US8212004B2 (en) 1999-03-02 2012-07-03 Human Genome Sciences, Inc. Neutrokine-alpha fusion proteins
US7696327B1 (en) 1997-10-17 2010-04-13 Genentech, Inc. Antibodies to human Toll homologues
WO2001090151A2 (en) * 2000-05-25 2001-11-29 Schering Corporation Human receptor proteins; related reagents and methods
US20030032090A1 (en) 1997-05-07 2003-02-13 Schering Corporation, A New Jersey Corporation Human receptor proteins; related reagents and methods
IL135345A0 (en) * 1997-10-17 2001-05-20 Genentech Inc Human toll homologues
AU2003203679B2 (en) * 1997-10-17 2007-04-05 Genentech, Inc. Human toll homologues
JP2000128900A (ja) * 1998-10-26 2000-05-09 Japan Science & Technology Corp 新規トル様（Ｔｏｌｌ−ｌｉｋｅ）レセプター及びその遺伝子
US6303321B1 (en) 1999-02-11 2001-10-16 North Shore-Long Island Jewish Research Institute Methods for diagnosing sepsis
US6740487B1 (en) 1999-06-10 2004-05-25 University Of Iowa Research Foundation Variant TLR4 nucleic acid and uses thereof
EP1226252A2 (en) * 1999-11-02 2002-07-31 Chiron Corporation DOUBLE-STRANDED RNA RECEPTOR (dsRNA-R) AND METHODS RELATING THERETO
GB9927332D0 (en) * 1999-11-18 2000-01-12 Leiv Eiriksson Nyfotek As Novel antibody and uses thereof
GB0001704D0 (en) * 2000-01-25 2000-03-15 Glaxo Group Ltd Protein
US20030083244A1 (en) * 2000-04-26 2003-05-01 Vernet Corine A.M. Novel proteins and nucleic acids encoding same
MXPA02012434A (es) 2000-06-16 2004-09-06 Cambridge Antibody Tech Anticuerpos que se unen inmunoespecificamente a estimulador de linfocitos ii.
US7879328B2 (en) 2000-06-16 2011-02-01 Human Genome Sciences, Inc. Antibodies that immunospecifically bind to B lymphocyte stimulator
JP2002034565A (ja) * 2000-07-19 2002-02-05 Japan Science & Technology Corp 細菌ｄｎａを特異的に認識する受容体タンパク質
WO2002016411A2 (en) * 2000-08-18 2002-02-28 Human Genome Sciences, Inc. Binding polypeptides and methods based thereon
EP2267019A3 (en) * 2000-08-18 2011-07-06 Human Genome Sciences, Inc. Binding polypeptides for B lymphocyte stimulator protein (BLyS)
WO2002022809A2 (en) 2000-09-15 2002-03-21 Coley Pharmaceutical Gmbh PROCESS FOR HIGH THROUGHPUT SCREENING OF CpG-BASED IMMUNO-AGONIST/ANTAGONIST
US7304034B2 (en) 2001-05-15 2007-12-04 The Feinstein Institute For Medical Research Use of HMGB fragments as anti-inflammatory agents
US7220723B2 (en) 2001-05-15 2007-05-22 The Feinstein Institute For Medical Research Inhibitors of the interaction between HMGB polypeptides and toll-like receptor 2 as anti-inflammatory agents
CA2461315A1 (en) * 2001-10-05 2003-04-17 Coley Pharmaceutical Gmbh Toll-like receptor 3 signaling agonists and antagonists
AU2002343728A1 (en) * 2001-11-16 2003-06-10 3M Innovative Properties Company Methods and compositions related to irm compounds and toll-like receptor pathways
GB0127618D0 (en) * 2001-11-17 2002-01-09 Univ Nottingham "Composition and method for treatment of wounds"
JP2004016021A (ja) 2002-06-12 2004-01-22 Japan Science & Technology Corp 抗体および阻害剤並びにそれを用いた形質転換方法および形質転換キット
AU2003287316A1 (en) * 2002-12-11 2004-06-30 3M Innovative Properties Company Assays relating to toll-like receptor activity
EP1631687A2 (en) * 2003-04-22 2006-03-08 Coley Pharmaceutical GmbH Methods and products for identification and assessment of tlr ligands
US7696169B2 (en) 2003-06-06 2010-04-13 The Feinstein Institute For Medical Research Inhibitors of the interaction between HMGB polypeptides and toll-like receptor 2 as anti-inflammatory agents
JP4792392B2 (ja) 2003-09-11 2011-10-12 コーナーストーン セラピューティクス インコーポレイテッド Ｈｍｇｂ１に対するモノクローナル抗体
TW200516153A (en) * 2003-10-03 2005-05-16 Hitachi Chemical Co Ltd Human toll-like receptor 3 gene polymorphism as marker for inherited factor of allergic disease and utilization of the same
TW200514850A (en) * 2003-10-03 2005-05-01 Hitachi Chemical Co Ltd Method of evaluating risk for viral infection
US8871782B2 (en) 2003-10-03 2014-10-28 3M Innovative Properties Company Alkoxy substituted imidazoquinolines
WO2005039504A2 (en) 2003-10-24 2005-05-06 Eisai Co., Ltd. Compounds and methods for treating toll-like receptor 2-related diseases and conditions
RU2409576C2 (ru) 2003-11-25 2011-01-20 3М Инновейтив Пропертиз Компани Системы, содержащие имидазольное кольцо с заместителями, и способы их получения
JP2008022701A (ja) * 2004-09-24 2008-02-07 Japan Science & Technology Agency 可溶型Ｔｏｌｌ様受容体４タンパク質
CA2587676A1 (en) 2004-11-19 2006-05-26 Institut Gustave Roussy Improved treatment of cancer by double-stranded rna
AR051836A1 (es) 2004-11-30 2007-02-14 Centocor Inc Antagonistas de receptor 3 simil toll metodos y usos
US9248127B2 (en) 2005-02-04 2016-02-02 3M Innovative Properties Company Aqueous gel formulations containing immune response modifiers
US7700728B2 (en) 2005-03-24 2010-04-20 Schering Corporation Use of chimeric receptors in a screening assay for identifying agonists and antagonists of cell receptors
US7498409B2 (en) 2005-03-24 2009-03-03 Schering Corporation Screening assay for TLR7, TLR8 and TLR9 agonists and antagonists
US9168286B2 (en) 2005-10-13 2015-10-27 Human Genome Sciences, Inc. Methods and compositions for use in treatment of patients with autoantibody positive disease
JP5199878B2 (ja) 2005-10-27 2013-05-15 セントカー・インコーポレーテツド Ｔｏｌｌ様受容体３モジュレーター、方法および用途
CA2638760A1 (en) 2006-03-07 2007-09-13 Vaxinnate Corporation Compositions that include hemagglutinin, methods of making and methods of use thereof
US8211649B2 (en) 2006-03-31 2012-07-03 Human Genome Sciences, Inc. Methods of diagnosing and prognosing hodgkin's lymphoma
CN101134046B (zh) * 2006-09-01 2011-10-05 中国医学科学院药物研究所 Tlr4和tlr9激动剂复方在抑制肿瘤转移中的应用
WO2008147956A2 (en) * 2007-05-25 2008-12-04 Centocor, Inc. Toll-like receptor 3 modulators and uses thereof
WO2009130616A2 (en) 2008-04-25 2009-10-29 Innate Pharma Improved tlr3 agonist compositions
EP2116602A1 (en) 2008-05-07 2009-11-11 Institut Gustave Roussy Combination products for treating cancer
US8273541B2 (en) 2008-09-17 2012-09-25 Innate Pharma Compositions and methods for detecting TLR3
US9512196B2 (en) 2008-09-22 2016-12-06 Cedars-Sinai Medical Center Short-form human MD-2 as a negative regulator of toll-like receptor 4 signaling
EP2328911A4 (en) 2008-09-22 2012-03-14 Cedars Sinai Medical Center SHORT HUMAN MD-2 AS A NEGATIVE REGULATOR OF GREAT LIKE RECEPTOR 4 SIGNALING
DK2451844T3 (en) 2009-07-10 2015-07-27 Innate Pharma Tlr3-retention agents
JP5830744B2 (ja) * 2009-08-19 2015-12-09 国立大学法人東京工業大学 乳酸菌の付着性を誘導するペプチド及びその用途
AU2011281192A1 (en) 2010-07-19 2013-02-28 Yeda Research And Development Co. Ltd. Peptides based on the transmembrane domain of a Toll-like receptor (TLR) for treatment of TLR-mediated diseases
WO2013054329A1 (en) * 2011-10-10 2013-04-18 Yeda Research And Development Co. Ltd. Toll-like receptor 4 (tlr-4) agonist peptides for modulating tlr-4 mediated immune response
US9814740B2 (en) 2010-12-21 2017-11-14 Duke University Methods and compositions combining immunotherapy with monocyte activation
EP2663329A2 (en) 2011-01-12 2013-11-20 Innate Pharma Tlr3 binding agents
EP2713737B1 (en) 2011-06-01 2016-04-20 Janus Biotherapeutics, Inc. Novel immune system modulators
CN109912602A (zh) 2011-06-01 2019-06-21 贾纳斯生物治疗有限公司 新型免疫系统调节剂
JP2014528449A (ja) 2011-10-04 2014-10-27 ジャナス バイオセラピューティクス，インク． 新規なイミダゾールキノリン系免疫系調節剤
CN104379603B (zh) 2012-05-31 2017-11-07 先天制药公司 Tlr3结合剂
US10017739B2 (en) 2012-09-06 2018-07-10 Duke University Methods of expanding and assessing B cells and using expanded B cells to treat disease
CN113502299B (zh) * 2021-07-20 2023-03-14 中国农业大学 一种抗金黄色葡萄球菌遗传修饰山羊生产方法

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2046920B1 (enExample) 1969-06-19 1974-05-03 Citizen Watch Co Ltd
US3940475A (en) 1970-06-11 1976-02-24 Biological Developments, Inc. Radioimmune method of assaying quantitatively for a hapten
NL154598B (nl) 1970-11-10 1977-09-15 Organon Nv Werkwijze voor het aantonen en bepalen van laagmoleculire verbindingen en van eiwitten die deze verbindingen specifiek kunnen binden, alsmede testverpakking.
US3817837A (en) 1971-05-14 1974-06-18 Syva Corp Enzyme amplification assay
US3939350A (en) 1974-04-29 1976-02-17 Board Of Trustees Of The Leland Stanford Junior University Fluorescent immunoassay employing total reflection for activation
US3996345A (en) 1974-08-12 1976-12-07 Syva Company Fluorescence quenching with immunological pairs in immunoassays
US4277437A (en) 1978-04-05 1981-07-07 Syva Company Kit for carrying out chemically induced fluorescence immunoassay
US4275149A (en) 1978-11-24 1981-06-23 Syva Company Macromolecular environment control in specific receptor assays
US4366241A (en) 1980-08-07 1982-12-28 Syva Company Concentrating zone method in heterogeneous immunoassays
US4659678A (en) 1982-09-29 1987-04-21 Serono Diagnostics Limited Immunoassay of antigens
US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
US4859609A (en) 1986-04-30 1989-08-22 Genentech, Inc. Novel receptors for efficient determination of ligands and their antagonists or agonists
US5789192A (en) 1992-12-10 1998-08-04 Schering Corporation Mammalian receptors for interleukin-10 (IL-10)
AU3514997A (en) * 1996-07-12 1998-02-09 Schering Corporation Mammalian tnf-alpha convertases
JP2001512011A (ja) * 1997-08-01 2001-08-21 ジェンセット 組織非特異的分泌タンパク質の５’ｅｓｔ
IL135345A0 (en) * 1997-10-17 2001-05-20 Genentech Inc Human toll homologues

Also Published As

Publication number Publication date
JP2009089713A (ja) 2009-04-30
CA2289912A1 (en) 1998-11-12
EP0980429B1 (en) 2006-12-13
DK0980429T3 (da) 2007-04-10
DE69841514D1 (de) 2010-04-01
ID28299A (id) 2001-05-10
EP1798288B1 (en) 2009-09-16
EP1988166A1 (en) 2008-11-05
NO995458D0 (no) 1999-11-08
JP2005120106A (ja) 2005-05-12
EP1925666B1 (en) 2010-02-17
PT1798288E (pt) 2009-12-23
WO1998050547A3 (en) 1999-03-11
DE69836630T2 (de) 2007-10-11
ES2279572T3 (es) 2007-08-16
JP2002514083A (ja) 2002-05-14
EP1798288A3 (en) 2007-09-12
PL336635A1 (en) 2000-07-03
CN1225555C (zh) 2005-11-02
CN1800214A (zh) 2006-07-12
ATE458053T1 (de) 2010-03-15
ES2340210T3 (es) 2010-05-31
EP1798288A2 (en) 2007-06-20
JP2006052232A (ja) 2006-02-23
HK1022175A1 (en) 2000-07-28
KR100388860B1 (ko) 2003-06-25
AU7175498A (en) 1998-11-27
DE69836630D1 (de) 2007-01-25
EP1925666A1 (en) 2008-05-28
NZ338073A (en) 2001-09-28
HK1102720A1 (en) 2007-12-07
ES2331622T3 (es) 2010-01-11
SK146599A3 (en) 2000-07-11
KR20010012323A (ko) 2001-02-15
DK1798288T3 (da) 2010-01-04
CN1263555A (zh) 2000-08-16
AU740333B2 (en) 2001-11-01
ATE348157T1 (de) 2007-01-15
EP0980429A2 (en) 2000-02-23
HK1112018A1 (en) 2008-08-22
CN101486759A (zh) 2009-07-22
CN1935840A (zh) 2007-03-28
DE69841170D1 (de) 2009-10-29
ATE443139T1 (de) 2009-10-15
NO995458L (no) 1999-11-08
IL132614A0 (en) 2001-03-19
WO1998050547A2 (en) 1998-11-12
CA2289912C (en) 2011-07-26

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