JP2017509335A5 - - Google Patents
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- Publication number
- JP2017509335A5 JP2017509335A5 JP2016555472A JP2016555472A JP2017509335A5 JP 2017509335 A5 JP2017509335 A5 JP 2017509335A5 JP 2016555472 A JP2016555472 A JP 2016555472A JP 2016555472 A JP2016555472 A JP 2016555472A JP 2017509335 A5 JP2017509335 A5 JP 2017509335A5
- Authority
- JP
- Japan
- Prior art keywords
- fusion protein
- residue
- multimeric fusion
- region
- heavy chain
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 108020001507 fusion proteins Proteins 0.000 claims 18
- 102000037865 fusion proteins Human genes 0.000 claims 18
- 229920001184 polypeptide Polymers 0.000 claims 8
- 102000004196 processed proteins & peptides Human genes 0.000 claims 8
- 108090000765 processed proteins & peptides Proteins 0.000 claims 8
- 239000000178 monomer Substances 0.000 claims 5
- 125000003607 serino group Chemical group [H]N([H])[C@]([H])(C(=O)[*])C(O[H])([H])[H] 0.000 claims 5
- 125000003295 alanine group Chemical group N[C@@H](C)C(=O)* 0.000 claims 4
- COLNVLDHVKWLRT-QMMMGPOBSA-N phenylalanine group Chemical group N[C@@H](CC1=CC=CC=C1)C(=O)O COLNVLDHVKWLRT-QMMMGPOBSA-N 0.000 claims 4
- 125000001909 leucine group Chemical group [H]N(*)C(C(*)=O)C([H])([H])C(C([H])([H])[H])C([H])([H])[H] 0.000 claims 3
- 125000001500 prolyl group Chemical group [H]N1C([H])(C(=O)[*])C([H])([H])C([H])([H])C1([H])[H] 0.000 claims 3
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 2
- 238000010367 cloning Methods 0.000 claims 2
- 239000013604 expression vector Substances 0.000 claims 2
- 125000003630 glycyl group Chemical group [H]N([H])C([H])([H])C(*)=O 0.000 claims 2
- WLKSPGHQGFFKGE-UHFFFAOYSA-N 1-chloropropan-2-yl n-(3-chlorophenyl)carbamate Chemical compound ClCC(C)OC(=O)NC1=CC=CC(Cl)=C1 WLKSPGHQGFFKGE-UHFFFAOYSA-N 0.000 claims 1
- 230000004931 aggregating effect Effects 0.000 claims 1
- 235000001014 amino acid Nutrition 0.000 claims 1
- 150000001413 amino acids Chemical class 0.000 claims 1
- 239000013599 cloning vector Substances 0.000 claims 1
- 230000000295 complement effect Effects 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 125000000151 cysteine group Chemical group N[C@@H](CS)C(=O)* 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 230000004927 fusion Effects 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 230000035772 mutation Effects 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
- 125000001493 tyrosinyl group Chemical group [H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])(N([H])[H])C(*)=O 0.000 claims 1
Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB1403914.3 | 2014-03-05 | ||
| GB201403914A GB201403914D0 (en) | 2014-03-05 | 2014-03-05 | Proteins |
| GB1403915.0 | 2014-03-05 | ||
| GB201403915A GB201403915D0 (en) | 2014-03-05 | 2014-03-05 | Proteins |
| GBGB1405955.4A GB201405955D0 (en) | 2014-04-02 | 2014-04-02 | Proteins |
| GB1405955.4 | 2014-04-02 | ||
| GB1412648.6 | 2014-07-16 | ||
| GB201412648A GB201412648D0 (en) | 2014-07-16 | 2014-07-16 | Proteins |
| PCT/EP2015/054688 WO2015132365A1 (en) | 2014-03-05 | 2015-03-05 | Multimeric fc proteins |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017509335A JP2017509335A (ja) | 2017-04-06 |
| JP2017509335A5 true JP2017509335A5 (enExample) | 2018-04-12 |
| JP6851199B2 JP6851199B2 (ja) | 2021-03-31 |
Family
ID=52697365
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016555472A Expired - Fee Related JP6851199B2 (ja) | 2014-03-05 | 2015-03-05 | 多量体Ｆｃタンパク質 |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US20170081406A1 (enExample) |
| EP (1) | EP3114137A1 (enExample) |
| JP (1) | JP6851199B2 (enExample) |
| KR (1) | KR20160127821A (enExample) |
| CN (1) | CN106132994A (enExample) |
| AU (1) | AU2015226101B2 (enExample) |
| BR (1) | BR112016020377A2 (enExample) |
| CA (1) | CA2939201A1 (enExample) |
| IL (1) | IL247246A0 (enExample) |
| MX (1) | MX2016010953A (enExample) |
| RU (1) | RU2016139022A (enExample) |
| SG (1) | SG11201606596PA (enExample) |
| WO (1) | WO2015132365A1 (enExample) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3114143B1 (en) | 2014-03-05 | 2020-07-08 | UCB Biopharma SRL | Multimeric fc proteins |
| JP2017518965A (ja) | 2014-05-02 | 2017-07-13 | モメンタ ファーマシューティカルズ インコーポレイテッ | エンジニアリングされたＦｃ構築物に関連する組成物および方法 |
| GB201511787D0 (en) * | 2015-07-06 | 2015-08-19 | Ucb Biopharma Sprl | Proteins |
| GB201513033D0 (en) * | 2015-07-23 | 2015-09-09 | Ucb Biopharma Sprl | Proteins |
| IL309260B2 (en) | 2015-07-24 | 2025-01-01 | Gliknik Inc | Fusion proteins of human protein fragments to create ordered multimeric immunoglobulin FC preparations with enhanced complement binding |
| BR112018014668A2 (pt) * | 2016-01-27 | 2018-12-11 | Csl Behring Recombinant Facility Ag | multímeros de fc de igg recombinante |
| WO2017151971A2 (en) | 2016-03-02 | 2017-09-08 | Momenta Pharmaceuticals, Inc. | METHODS RELATED TO ENGINEERED Fc CONSTRUCTS |
| DK3484514T3 (da) | 2016-05-23 | 2024-01-29 | Momenta Pharmaceuticals Inc | Compositions and methods related to engineered fc constructs |
| AU2017279538A1 (en) | 2016-06-07 | 2019-01-03 | Gliknik Inc. | Cysteine-optimized stradomers |
| CN109641048A (zh) | 2016-07-22 | 2019-04-16 | 格利克尼克股份有限公司 | 产生具有增强的Fc受体结合的经有序多聚化的免疫球蛋白Fc组合物的人蛋白片段的融合蛋白 |
| US11331372B2 (en) | 2016-12-09 | 2022-05-17 | Gliknik Inc. | Methods of treating inflammatory disorders with multivalent Fc compounds |
| SG11201906139VA (en) | 2017-01-06 | 2019-08-27 | Momenta Pharmaceuticals Inc | Compositions and methods related to engineered fc constructs |
| JP7395463B2 (ja) * | 2017-03-28 | 2023-12-11 | リビジェン バイオファーマ ホールディングス リミテッド | 腫瘍微小環境における免疫応答を増強するための治療剤および方法 |
| ES2975776T3 (es) * | 2017-12-14 | 2024-07-15 | CSL Behring Lengnau AG | Multímeros de Fc de IgG recombinantes para el tratamiento de la neuromielitis óptica |
| EP3880248A4 (en) | 2018-11-14 | 2022-08-10 | JN Biosciences, LLC | MULTIMERIC HYBRID FC PROTEINS FOR IV IG REPLACEMENT |
| GB201903767D0 (en) * | 2019-03-19 | 2019-05-01 | Quadrucept Bio Ltd | Multimers, tetramers & octamers |
| US20220332847A1 (en) | 2019-09-13 | 2022-10-20 | CSL Behring Lengnau AG | RECOMBINANT IgG Fc MULTIMERS FOR THE TREATMENT OF IMMUNE COMPLEX-MEDIATED KIDNEY DISORDERS |
| CA3159705A1 (en) * | 2019-12-06 | 2021-06-10 | CSL Behring Lengnau AG | Stable compositions of fc multimers |
| CN115724985A (zh) * | 2021-08-27 | 2023-03-03 | 三生国健药业（上海）股份有限公司 | 一种cdc平台抗体 |
| CN117925664B (zh) * | 2023-11-29 | 2025-01-21 | 上海科锐克医药科技有限公司 | 用于递送人vegf受体融合蛋白的基因递送载体及其应用 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SI2250279T1 (sl) * | 2008-02-08 | 2016-10-28 | Medimmune, Llc | Protitelesa anti-IFNAR1 z zmanjšano afiniteto do FC liganda |
| RU2540018C2 (ru) * | 2008-03-13 | 2015-01-27 | Биотест Аг | Средство для лечения заболевания |
| EP2389192A4 (en) * | 2009-01-23 | 2013-01-16 | Biogen Idec Inc | STABILIZED FC POLYPEPTIDES WITH REDUCED EFFECTOR FUNCTION AND METHOD OF USE |
| CN103974977A (zh) * | 2011-09-26 | 2014-08-06 | Jn生物科学有限责任公司 | 杂交恒定区 |
| JP2015524821A (ja) * | 2012-08-02 | 2015-08-27 | ジェイエヌ バイオサイエンシーズ エルエルシー | システイン変異及びμ尾部を介して多量体化した抗体又は融合タンパク質 |
-
2015
- 2015-03-05 AU AU2015226101A patent/AU2015226101B2/en not_active Ceased
- 2015-03-05 KR KR1020167027644A patent/KR20160127821A/ko not_active Withdrawn
- 2015-03-05 WO PCT/EP2015/054688 patent/WO2015132365A1/en not_active Ceased
- 2015-03-05 BR BR112016020377A patent/BR112016020377A2/pt not_active Application Discontinuation
- 2015-03-05 EP EP15711066.9A patent/EP3114137A1/en not_active Withdrawn
- 2015-03-05 JP JP2016555472A patent/JP6851199B2/ja not_active Expired - Fee Related
- 2015-03-05 RU RU2016139022A patent/RU2016139022A/ru not_active Application Discontinuation
- 2015-03-05 MX MX2016010953A patent/MX2016010953A/es unknown
- 2015-03-05 US US15/123,066 patent/US20170081406A1/en not_active Abandoned
- 2015-03-05 CA CA2939201A patent/CA2939201A1/en not_active Abandoned
- 2015-03-05 SG SG11201606596PA patent/SG11201606596PA/en unknown
- 2015-03-05 CN CN201580011852.3A patent/CN106132994A/zh active Pending
-
2016
- 2016-08-11 IL IL247246A patent/IL247246A0/en unknown
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