JP2017509335A5 - - Google Patents

Info

Publication number

JP2017509335A5

JP2017509335A5 JP2016555472A JP2016555472A JP2017509335A5 JP 2017509335 A5 JP2017509335 A5 JP 2017509335A5 JP 2016555472 A JP2016555472 A JP 2016555472A JP 2016555472 A JP2016555472 A JP 2016555472A JP 2017509335 A5 JP2017509335 A5 JP 2017509335A5

Authority

JP

Japan

Prior art keywords

fusion protein

residue

multimeric fusion

region

heavy chain

Prior art date

2015-03-05

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
• Discuss

• 108020001507 fusion proteins Proteins 0.000 claims 18
• 102000037865 fusion proteins Human genes 0.000 claims 18
• 229920001184 polypeptide Polymers 0.000 claims 8
• 102000004196 processed proteins & peptides Human genes 0.000 claims 8
• 108090000765 processed proteins & peptides Proteins 0.000 claims 8
• 239000000178 monomer Substances 0.000 claims 5
• 125000003607 serino group Chemical group [H]N([H])[C@]([H])(C(=O)[*])C(O[H])([H])[H] 0.000 claims 5
• 125000003295 alanine group Chemical group N[C@@H](C)C(=O)* 0.000 claims 4
• COLNVLDHVKWLRT-QMMMGPOBSA-N phenylalanine group Chemical group N[C@@H](CC1=CC=CC=C1)C(=O)O COLNVLDHVKWLRT-QMMMGPOBSA-N 0.000 claims 4
• 125000001909 leucine group Chemical group [H]N(*)C(C(*)=O)C([H])([H])C(C([H])([H])[H])C([H])([H])[H] 0.000 claims 3
• 125000001500 prolyl group Chemical group [H]N1C([H])(C(=O)[*])C([H])([H])C([H])([H])C1([H])[H] 0.000 claims 3
• 108091028043 Nucleic acid sequence Proteins 0.000 claims 2
• 238000010367 cloning Methods 0.000 claims 2
• 239000013604 expression vector Substances 0.000 claims 2
• 125000003630 glycyl group Chemical group [H]N([H])C([H])([H])C(*)=O 0.000 claims 2
• WLKSPGHQGFFKGE-UHFFFAOYSA-N 1-chloropropan-2-yl n-(3-chlorophenyl)carbamate Chemical compound ClCC(C)OC(=O)NC1=CC=CC(Cl)=C1 WLKSPGHQGFFKGE-UHFFFAOYSA-N 0.000 claims 1
• 230000004931 aggregating effect Effects 0.000 claims 1
• 235000001014 amino acid Nutrition 0.000 claims 1
• 150000001413 amino acids Chemical class 0.000 claims 1
• 239000013599 cloning vector Substances 0.000 claims 1
• 230000000295 complement effect Effects 0.000 claims 1
• 238000012258 culturing Methods 0.000 claims 1
• 125000000151 cysteine group Chemical group N[C@@H](CS)C(=O)* 0.000 claims 1
• 239000003085 diluting agent Substances 0.000 claims 1
• 230000004927 fusion Effects 0.000 claims 1
• 238000004519 manufacturing process Methods 0.000 claims 1
• 238000000034 method Methods 0.000 claims 1
• 230000035772 mutation Effects 0.000 claims 1
• 239000008194 pharmaceutical composition Substances 0.000 claims 1
• 239000000546 pharmaceutical excipient Substances 0.000 claims 1
• 108090000623 proteins and genes Proteins 0.000 claims 1
• 102000004169 proteins and genes Human genes 0.000 claims 1
• 125000001493 tyrosinyl group Chemical group [H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])(N([H])[H])C(*)=O 0.000 claims 1