JP2017509335A5 - - Google Patents
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- Publication number
- JP2017509335A5 JP2017509335A5 JP2016555472A JP2016555472A JP2017509335A5 JP 2017509335 A5 JP2017509335 A5 JP 2017509335A5 JP 2016555472 A JP2016555472 A JP 2016555472A JP 2016555472 A JP2016555472 A JP 2016555472A JP 2017509335 A5 JP2017509335 A5 JP 2017509335A5
- Authority
- JP
- Japan
- Prior art keywords
- fusion protein
- residue
- multimeric fusion
- region
- heavy chain
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 108020001507 fusion proteins Proteins 0.000 claims 18
- 102000037865 fusion proteins Human genes 0.000 claims 18
- 229920001184 polypeptide Polymers 0.000 claims 8
- 102000004196 processed proteins & peptides Human genes 0.000 claims 8
- 108090000765 processed proteins & peptides Proteins 0.000 claims 8
- 239000000178 monomer Substances 0.000 claims 5
- 125000003607 serino group Chemical group [H]N([H])[C@]([H])(C(=O)[*])C(O[H])([H])[H] 0.000 claims 5
- 125000003295 alanine group Chemical group N[C@@H](C)C(=O)* 0.000 claims 4
- COLNVLDHVKWLRT-QMMMGPOBSA-N phenylalanine group Chemical group N[C@@H](CC1=CC=CC=C1)C(=O)O COLNVLDHVKWLRT-QMMMGPOBSA-N 0.000 claims 4
- 125000001909 leucine group Chemical group [H]N(*)C(C(*)=O)C([H])([H])C(C([H])([H])[H])C([H])([H])[H] 0.000 claims 3
- 125000001500 prolyl group Chemical group [H]N1C([H])(C(=O)[*])C([H])([H])C([H])([H])C1([H])[H] 0.000 claims 3
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 2
- 238000010367 cloning Methods 0.000 claims 2
- 239000013604 expression vector Substances 0.000 claims 2
- 125000003630 glycyl group Chemical group [H]N([H])C([H])([H])C(*)=O 0.000 claims 2
- WLKSPGHQGFFKGE-UHFFFAOYSA-N 1-chloropropan-2-yl n-(3-chlorophenyl)carbamate Chemical compound ClCC(C)OC(=O)NC1=CC=CC(Cl)=C1 WLKSPGHQGFFKGE-UHFFFAOYSA-N 0.000 claims 1
- 230000004931 aggregating effect Effects 0.000 claims 1
- 235000001014 amino acid Nutrition 0.000 claims 1
- 150000001413 amino acids Chemical class 0.000 claims 1
- 239000013599 cloning vector Substances 0.000 claims 1
- 230000000295 complement effect Effects 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 125000000151 cysteine group Chemical group N[C@@H](CS)C(=O)* 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 230000004927 fusion Effects 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 230000035772 mutation Effects 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
- 125000001493 tyrosinyl group Chemical group [H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])(N([H])[H])C(*)=O 0.000 claims 1
Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB201403914A GB201403914D0 (en) | 2014-03-05 | 2014-03-05 | Proteins |
| GB1403915.0 | 2014-03-05 | ||
| GB1403914.3 | 2014-03-05 | ||
| GB201403915A GB201403915D0 (en) | 2014-03-05 | 2014-03-05 | Proteins |
| GBGB1405955.4A GB201405955D0 (en) | 2014-04-02 | 2014-04-02 | Proteins |
| GB1405955.4 | 2014-04-02 | ||
| GB1412648.6 | 2014-07-16 | ||
| GB201412648A GB201412648D0 (en) | 2014-07-16 | 2014-07-16 | Proteins |
| PCT/EP2015/054688 WO2015132365A1 (en) | 2014-03-05 | 2015-03-05 | Multimeric fc proteins |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017509335A JP2017509335A (ja) | 2017-04-06 |
| JP2017509335A5 true JP2017509335A5 (enExample) | 2018-04-12 |
| JP6851199B2 JP6851199B2 (ja) | 2021-03-31 |
Family
ID=52697365
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016555472A Expired - Fee Related JP6851199B2 (ja) | 2014-03-05 | 2015-03-05 | 多量体Ｆｃタンパク質 |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US20170081406A1 (enExample) |
| EP (1) | EP3114137A1 (enExample) |
| JP (1) | JP6851199B2 (enExample) |
| KR (1) | KR20160127821A (enExample) |
| CN (1) | CN106132994A (enExample) |
| AU (1) | AU2015226101B2 (enExample) |
| BR (1) | BR112016020377A2 (enExample) |
| CA (1) | CA2939201A1 (enExample) |
| IL (1) | IL247246A0 (enExample) |
| MX (1) | MX2016010953A (enExample) |
| RU (1) | RU2016139022A (enExample) |
| SG (1) | SG11201606596PA (enExample) |
| WO (1) | WO2015132365A1 (enExample) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW201619188A (zh) | 2014-03-05 | 2016-06-01 | 優稀美生物醫藥公司 | 多聚體Ｆｃ蛋白質 |
| JP2017518965A (ja) | 2014-05-02 | 2017-07-13 | モメンタ ファーマシューティカルズ インコーポレイテッ | エンジニアリングされたＦｃ構築物に関連する組成物および方法 |
| GB201511787D0 (en) * | 2015-07-06 | 2015-08-19 | Ucb Biopharma Sprl | Proteins |
| GB201513033D0 (en) * | 2015-07-23 | 2015-09-09 | Ucb Biopharma Sprl | Proteins |
| RU2737378C2 (ru) | 2015-07-24 | 2020-11-27 | Гликник Инк. | Гибридные белки фрагментов белков человека для создания упорядоченно мультимеризованных композиций областей fc иммуноглобулинов с усиленным связыванием с системой комплемента |
| WO2017129737A1 (en) * | 2016-01-27 | 2017-08-03 | Csl Behring Recombinant Facility Ag | Recombinant igg fc multimers |
| EP3423572B1 (en) | 2016-03-02 | 2023-11-29 | Momenta Pharmaceuticals, Inc. | Methods related to engineered fc constructs |
| WO2017205436A1 (en) | 2016-05-23 | 2017-11-30 | Momenta Pharmaceuticals, Inc. | Compositions and methods related to engineered fc constructs |
| AU2017279538A1 (en) | 2016-06-07 | 2019-01-03 | Gliknik Inc. | Cysteine-optimized stradomers |
| US20190389941A1 (en) | 2016-07-22 | 2019-12-26 | Gliknik Inc. | Fusion proteins of human protein fragments to create orderly multimerized immunoglobulin fc compositions with enhanced fc receptor binding |
| BR112019009495A2 (pt) | 2016-12-09 | 2019-08-06 | Gliknik Inc | métodos de tratamento de distúrbios inflamatórios com compostos de fc multivalentes |
| US11220531B2 (en) | 2017-01-06 | 2022-01-11 | Janssen Biotech, Inc. | Engineered Fc constructs |
| CN110546162B (zh) * | 2017-03-28 | 2021-09-07 | 礼进生物医药科技（上海）有限公司 | 用于增强肿瘤微环境中免疫应答的治疗剂和方法 |
| WO2019115745A1 (en) | 2017-12-14 | 2019-06-20 | CSL Behring Lengnau AG | RECOMBINANT igG Fc MULTIMERS FOR THE TREATMENT OF NEUROMYELITIS OPTICA |
| US12492231B2 (en) | 2018-11-14 | 2025-12-09 | Jn Biosciences Llc | Multimeric hybrid Fc proteins for replacement of IVIG |
| GB201903767D0 (en) * | 2019-03-19 | 2019-05-01 | Quadrucept Bio Ltd | Multimers, tetramers & octamers |
| US20220332847A1 (en) | 2019-09-13 | 2022-10-20 | CSL Behring Lengnau AG | RECOMBINANT IgG Fc MULTIMERS FOR THE TREATMENT OF IMMUNE COMPLEX-MEDIATED KIDNEY DISORDERS |
| MX2022006703A (es) * | 2019-12-06 | 2022-07-12 | CSL Behring Lengnau AG | Composiciones estables de multimeros fc. |
| CN115724985A (zh) * | 2021-08-27 | 2023-03-03 | 三生国健药业（上海）股份有限公司 | 一种cdc平台抗体 |
| CN117925664B (zh) * | 2023-11-29 | 2025-01-21 | 上海科锐克医药科技有限公司 | 用于递送人vegf受体融合蛋白的基因递送载体及其应用 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101952454B (zh) * | 2008-02-08 | 2014-06-04 | 米迪缪尼有限公司 | 具有减弱的Fc配体亲和性的抗IFNAR1抗体 |
| EP2260057B1 (en) * | 2008-03-13 | 2016-11-23 | Biotest AG | Anti-CD4 antibody dosage regimen for treating autoimmune disease |
| WO2010085682A2 (en) * | 2009-01-23 | 2010-07-29 | Biogen Idec Ma Inc. | Stabilized fc polypeptides with reduced effector function and methods of use |
| EP2760891B1 (en) * | 2011-09-26 | 2018-11-07 | JN Biosciences LLC | Hybrid constant regions |
| WO2014022592A1 (en) * | 2012-08-02 | 2014-02-06 | Jn Biosciences Llc | Antibodies or fusion proteins multimerized via cysteine mutation and a mu tailpiece |
-
2015
- 2015-03-05 CN CN201580011852.3A patent/CN106132994A/zh active Pending
- 2015-03-05 US US15/123,066 patent/US20170081406A1/en not_active Abandoned
- 2015-03-05 BR BR112016020377A patent/BR112016020377A2/pt not_active Application Discontinuation
- 2015-03-05 AU AU2015226101A patent/AU2015226101B2/en not_active Ceased
- 2015-03-05 SG SG11201606596PA patent/SG11201606596PA/en unknown
- 2015-03-05 MX MX2016010953A patent/MX2016010953A/es unknown
- 2015-03-05 KR KR1020167027644A patent/KR20160127821A/ko not_active Withdrawn
- 2015-03-05 RU RU2016139022A patent/RU2016139022A/ru not_active Application Discontinuation
- 2015-03-05 JP JP2016555472A patent/JP6851199B2/ja not_active Expired - Fee Related
- 2015-03-05 CA CA2939201A patent/CA2939201A1/en not_active Abandoned
- 2015-03-05 WO PCT/EP2015/054688 patent/WO2015132365A1/en not_active Ceased
- 2015-03-05 EP EP15711066.9A patent/EP3114137A1/en not_active Withdrawn
-
2016
- 2016-08-11 IL IL247246A patent/IL247246A0/en unknown
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