JP2017512063A5 - - Google Patents
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- Publication number
- JP2017512063A5 JP2017512063A5 JP2016555527A JP2016555527A JP2017512063A5 JP 2017512063 A5 JP2017512063 A5 JP 2017512063A5 JP 2016555527 A JP2016555527 A JP 2016555527A JP 2016555527 A JP2016555527 A JP 2016555527A JP 2017512063 A5 JP2017512063 A5 JP 2017512063A5
- Authority
- JP
- Japan
- Prior art keywords
- fusion protein
- residue
- multimeric fusion
- region
- heavy chain
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 108020001507 fusion proteins Proteins 0.000 claims 18
- 102000037865 fusion proteins Human genes 0.000 claims 18
- 229920001184 polypeptide Polymers 0.000 claims 8
- 102000004196 processed proteins & peptides Human genes 0.000 claims 8
- 108090000765 processed proteins & peptides Proteins 0.000 claims 8
- 239000000178 monomer Substances 0.000 claims 6
- 125000003607 serino group Chemical group [H]N([H])[C@]([H])(C(=O)[*])C(O[H])([H])[H] 0.000 claims 5
- 125000003295 alanine group Chemical group N[C@@H](C)C(=O)* 0.000 claims 4
- COLNVLDHVKWLRT-QMMMGPOBSA-N phenylalanine group Chemical group N[C@@H](CC1=CC=CC=C1)C(=O)O COLNVLDHVKWLRT-QMMMGPOBSA-N 0.000 claims 4
- 125000001909 leucine group Chemical group [H]N(*)C(C(*)=O)C([H])([H])C(C([H])([H])[H])C([H])([H])[H] 0.000 claims 3
- 125000001500 prolyl group Chemical group [H]N1C([H])(C(=O)[*])C([H])([H])C([H])([H])C1([H])[H] 0.000 claims 3
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 2
- 210000004027 cell Anatomy 0.000 claims 2
- 238000010367 cloning Methods 0.000 claims 2
- 239000013604 expression vector Substances 0.000 claims 2
- 125000003630 glycyl group Chemical group [H]N([H])C([H])([H])C(*)=O 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- WLKSPGHQGFFKGE-UHFFFAOYSA-N 1-chloropropan-2-yl n-(3-chlorophenyl)carbamate Chemical compound ClCC(C)OC(=O)NC1=CC=CC(Cl)=C1 WLKSPGHQGFFKGE-UHFFFAOYSA-N 0.000 claims 1
- 108020004414 DNA Proteins 0.000 claims 1
- 235000001014 amino acid Nutrition 0.000 claims 1
- 125000000539 amino acid group Chemical group 0.000 claims 1
- 150000001413 amino acids Chemical class 0.000 claims 1
- 210000004899 c-terminal region Anatomy 0.000 claims 1
- 239000013599 cloning vector Substances 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 235000018417 cysteine Nutrition 0.000 claims 1
- XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 claims 1
- 125000000151 cysteine group Chemical group N[C@@H](CS)C(=O)* 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 230000004927 fusion Effects 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
- 125000001493 tyrosinyl group Chemical group [H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])(N([H])[H])C(*)=O 0.000 claims 1
Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB201403913A GB201403913D0 (en) | 2014-03-05 | 2014-03-05 | Proteins |
| GB201403912A GB201403912D0 (en) | 2014-03-05 | 2014-03-05 | Proteins |
| GB1403912.7 | 2014-03-05 | ||
| GB1403913.5 | 2014-03-05 | ||
| GB201405952A GB201405952D0 (en) | 2014-04-02 | 2014-04-02 | Proteins |
| GB1405952.1 | 2014-04-02 | ||
| GB201412646A GB201412646D0 (en) | 2014-07-16 | 2014-07-16 | Proteins |
| GB1412646.0 | 2014-07-16 | ||
| PCT/EP2015/054687 WO2015132364A1 (en) | 2014-03-05 | 2015-03-05 | Multimeric fc proteins |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017512063A JP2017512063A (ja) | 2017-05-18 |
| JP2017512063A5 true JP2017512063A5 (enExample) | 2018-04-12 |
| JP6851200B2 JP6851200B2 (ja) | 2021-03-31 |
Family
ID=52629578
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016555527A Expired - Fee Related JP6851200B2 (ja) | 2014-03-05 | 2015-03-05 | 多量体Ｆｃタンパク質 |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US11352414B2 (enExample) |
| EP (1) | EP3114143B1 (enExample) |
| JP (1) | JP6851200B2 (enExample) |
| KR (1) | KR20160130463A (enExample) |
| CN (1) | CN106068274A (enExample) |
| AU (1) | AU2015226100B2 (enExample) |
| BR (1) | BR112016020368A2 (enExample) |
| CA (1) | CA2939198A1 (enExample) |
| IL (1) | IL247096A0 (enExample) |
| MX (1) | MX2016010951A (enExample) |
| RU (1) | RU2016139006A (enExample) |
| SG (1) | SG11201606597QA (enExample) |
| TW (1) | TW201619188A (enExample) |
| UY (1) | UY36021A (enExample) |
| WO (1) | WO2015132364A1 (enExample) |
Families Citing this family (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2016139006A (ru) | 2014-03-05 | 2018-04-05 | Юсб Биофарма Спрл | Мультимерные fc-белки |
| CN113501880A (zh) | 2014-05-02 | 2021-10-15 | 动量制药公司 | 涉及工程化Fc构建体的组合物和方法 |
| WO2016193380A1 (en) | 2015-06-02 | 2016-12-08 | Novo Nordisk A/S | Insulins with polar recombinant extensions |
| GB201511787D0 (en) * | 2015-07-06 | 2015-08-19 | Ucb Biopharma Sprl | Proteins |
| GB201513033D0 (en) * | 2015-07-23 | 2015-09-09 | Ucb Biopharma Sprl | Proteins |
| HUE053062T2 (hu) | 2015-07-24 | 2021-06-28 | Gliknik Inc | Humán fehérjefragmensek fúziós fehérjéi szabályosan multimerizált, fokozott komplementkötésû immunglobulin FC kompozíciók elõállításához |
| MA43348A (fr) | 2015-10-01 | 2018-08-08 | Novo Nordisk As | Conjugués de protéines |
| US20190119377A1 (en) * | 2016-01-27 | 2019-04-25 | Csl Behring Recombinant Facility Ag | Recombinant igg fc multimers |
| WO2017151971A2 (en) | 2016-03-02 | 2017-09-08 | Momenta Pharmaceuticals, Inc. | METHODS RELATED TO ENGINEERED Fc CONSTRUCTS |
| GB201607979D0 (en) * | 2016-05-06 | 2016-06-22 | Liverpool School Tropical Medicine | Monomeric proteins and uses thereof |
| AU2017272111B2 (en) | 2016-05-23 | 2024-05-16 | Momenta Pharmaceuticals, Inc. | Compositions and methods related to engineered Fc constructs |
| EP3464347B1 (en) | 2016-06-07 | 2023-05-31 | Gliknik Inc. | Cysteine-optimized stradomers |
| US20190389941A1 (en) * | 2016-07-22 | 2019-12-26 | Gliknik Inc. | Fusion proteins of human protein fragments to create orderly multimerized immunoglobulin fc compositions with enhanced fc receptor binding |
| US11155574B2 (en) | 2016-12-09 | 2021-10-26 | Gliknik Inc. | Manufacturing optimization of GL-2045, a multimerizing stradomer |
| CA3043251A1 (en) | 2016-12-09 | 2018-06-14 | Gliknik Inc. | Methods of treating inflammatory disorders with multivalent fc compounds |
| SG10202107391YA (en) | 2017-01-06 | 2021-08-30 | Momenta Pharmaceuticals Inc | Compositions and methods related to engineered fc constructs |
| CN113603781B (zh) * | 2017-03-28 | 2022-09-02 | 礼进生物医药科技（上海）有限公司 | 用于增强肿瘤微环境中免疫应答的治疗剂和方法 |
| JP2020513019A (ja) | 2017-04-05 | 2020-04-30 | ノヴォ ノルディスク アー／エス | オリゴマー伸長インスリン−Ｆｃコンジュゲート |
| KR101913743B1 (ko) | 2017-04-07 | 2018-11-01 | 국민대학교 산학협력단 | 혈중 반감기 연장을 위한 항체 Fc 변이체들 |
| JP7710827B2 (ja) * | 2017-06-05 | 2025-07-22 | ヤンセン バイオテツク，インコーポレーテツド | 非対称なｃｈ２－ｃｈ３領域の変異を有する、操作された多重特異性抗体及び他の多量体タンパク質 |
| CN112004550A (zh) * | 2017-12-14 | 2020-11-27 | 康诺贝林伦瑙有限公司 | 用于治疗视神经脊髓炎的重组IgG Fc多聚体 |
| AU2019235513A1 (en) * | 2018-03-16 | 2020-10-08 | Liverpool School Of Tropical Medicine | Chimeric Fc receptor binding proteins and uses thereof |
| KR102232659B1 (ko) * | 2018-07-16 | 2021-03-26 | 전북대학교 산학협력단 | 항원전달용 폴리펩타이드, 이를 포함하는 Fc-융합 단백질 및 이의 용도 |
| US12492231B2 (en) | 2018-11-14 | 2025-12-09 | Jn Biosciences Llc | Multimeric hybrid Fc proteins for replacement of IVIG |
| EP4028415A1 (en) | 2019-09-13 | 2022-07-20 | CSL Behring Lengnau AG | Recombinant igg fc multimers for the treatment of immune complex-mediated kidney disorders |
| CN114786721B (zh) * | 2019-12-06 | 2025-10-17 | 康诺贝林伦瑙有限公司 | Fc多聚体的稳定组合物 |
| GB2595299B (en) * | 2020-05-21 | 2022-08-03 | Mabsolve Ltd | Modified immunoglobulin FC regions |
| CN115724985A (zh) * | 2021-08-27 | 2023-03-03 | 三生国健药业（上海）股份有限公司 | 一种cdc平台抗体 |
| CA3258884A1 (en) * | 2022-06-10 | 2023-12-14 | Research Development Foundation | Modified FCRIIB Selective FC IGG1 Variants and Their Uses |
Family Cites Families (48)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5677425A (en) | 1987-09-04 | 1997-10-14 | Celltech Therapeutics Limited | Recombinant antibody |
| US20020147326A1 (en) * | 1996-06-14 | 2002-10-10 | Smithkline Beecham Corporation | Hexameric fusion proteins and uses therefor |
| US5980898A (en) | 1996-11-14 | 1999-11-09 | The United States Of America As Represented By The U.S. Army Medical Research & Material Command | Adjuvant for transcutaneous immunization |
| GB9625640D0 (en) | 1996-12-10 | 1997-01-29 | Celltech Therapeutics Ltd | Biological products |
| US6114515A (en) | 1997-08-25 | 2000-09-05 | Smithkline Beecham Corporation | PIGRL-1, a member of immunoglobulin gene superfamily |
| GB9720054D0 (en) | 1997-09-19 | 1997-11-19 | Celltech Therapeutics Ltd | Biological products |
| AU3369999A (en) | 1998-04-02 | 1999-10-25 | Genentech Inc. | Antibody variants and fragments thereof |
| AU3655899A (en) | 1998-04-20 | 1999-11-08 | Regents Of The University Of California, The | Modified immunoglobulin molecules and methods for use thereof |
| US6737056B1 (en) * | 1999-01-15 | 2004-05-18 | Genentech, Inc. | Polypeptide variants with altered effector function |
| MY129566A (en) | 1999-01-19 | 2007-04-30 | Nestle Sa | A hypoallergenic composition containing tolerogenic peptides inducing oral tolerance |
| US6475749B1 (en) | 1999-08-11 | 2002-11-05 | The Regents Of The University Of California | Rh hybrid antibody |
| DE10001372A1 (de) | 2000-01-14 | 2001-08-02 | Deutsches Krebsforsch | Anti-CD3-Einzelketten-Antikörper mit humanem Cmu3- und Cmu4- Domänen |
| KR100900176B1 (ko) | 2001-03-07 | 2009-06-02 | 메르크 파텐트 게엠베하 | 하이브리드 이소타입 항체 부분구조를 포함하는 단백질을위한 발현 기술 |
| KR100453877B1 (ko) | 2001-07-26 | 2004-10-20 | 메덱스젠 주식회사 | 연쇄체화에 의한 면역 글로블린 융합 단백질의 제조 방법 및 이 방법에 의해 제조된 ＴＮＦＲ/Ｆｃ 융합 단백질, 상기 단백질을 코딩하는 ＤＮＡ, 상기 ＤＮＡ를 포함하는벡터, 및 상기 벡터에 의한 형질전환체 |
| US7317091B2 (en) | 2002-03-01 | 2008-01-08 | Xencor, Inc. | Optimized Fc variants |
| US20040132101A1 (en) | 2002-09-27 | 2004-07-08 | Xencor | Optimized Fc variants and methods for their generation |
| CN101987871A (zh) | 2002-09-27 | 2011-03-23 | 赞科股份有限公司 | 优化的Fc变体及其产生方法 |
| US8388955B2 (en) * | 2003-03-03 | 2013-03-05 | Xencor, Inc. | Fc variants |
| GB0315457D0 (en) | 2003-07-01 | 2003-08-06 | Celltech R&D Ltd | Biological products |
| GB0315450D0 (en) | 2003-07-01 | 2003-08-06 | Celltech R&D Ltd | Biological products |
| DK1644412T4 (en) | 2003-07-01 | 2018-11-12 | Ucb Biopharma Sprl | MODIFIED ANTIBODY-FAB FRAGMENTS |
| US20060134105A1 (en) | 2004-10-21 | 2006-06-22 | Xencor, Inc. | IgG immunoglobulin variants with optimized effector function |
| WO2005063815A2 (en) | 2003-11-12 | 2005-07-14 | Biogen Idec Ma Inc. | Fcϝ receptor-binding polypeptide variants and methods related thereto |
| EP2471813B1 (en) | 2004-07-15 | 2014-12-31 | Xencor, Inc. | Optimized Fc variants |
| AU2007257692B2 (en) | 2006-06-12 | 2013-11-14 | Aptevo Research And Development Llc | Single-chain multivalent binding proteins with effector function |
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| NZ581395A (en) | 2007-05-14 | 2012-08-31 | Biogen Idec Inc | Single-chain fc (scfc) regions, binding polypeptides comprising same, and methods related thereto |
| CN103897063B (zh) * | 2007-06-01 | 2017-04-12 | 马里兰大学巴尔的摩分校 | 免疫球蛋白恒定区Fc受体结合剂 |
| AU2009224690B2 (en) * | 2008-03-13 | 2014-10-09 | Biotest Ag | Agent for treating disease |
| EP2389192A4 (en) * | 2009-01-23 | 2013-01-16 | Biogen Idec Inc | STABILIZED FC POLYPEPTIDES WITH REDUCED EFFECTOR FUNCTION AND METHOD OF USE |
| WO2011051350A1 (en) | 2009-10-27 | 2011-05-05 | Ucb Pharma S.A. | Function modifying nav 1.7 antibodies |
| GB0922209D0 (en) * | 2009-12-18 | 2010-02-03 | Univ Nottingham | Proteins, nucleic acid molecules and compositions |
| TWI588157B (zh) | 2010-07-28 | 2017-06-21 | 吉林尼克公司 | 產生依序多聚體化免疫球蛋白ｆｃ組合物之天然人類蛋白質片段之融合蛋白 |
| UA117901C2 (uk) | 2011-07-06 | 2018-10-25 | Ґенмаб Б.В. | Спосіб посилення ефекторної функції вихідного поліпептиду, його варіанти та їх застосування |
| EP2760891B1 (en) * | 2011-09-26 | 2018-11-07 | JN Biosciences LLC | Hybrid constant regions |
| CA2859785A1 (en) | 2011-12-21 | 2013-06-27 | Amgen Inc. | Variant fc-polypeptides with enhanced binding to the neonatal fc receptor |
| KR102041412B1 (ko) | 2011-12-30 | 2019-11-11 | 한미사이언스 주식회사 | 면역글로불린 Ｆｃ 단편 유도체 |
| SG11201408646VA (en) | 2012-07-06 | 2015-01-29 | Genmab Bv | Dimeric protein with triple mutations |
| US9540442B2 (en) * | 2012-08-02 | 2017-01-10 | Jn Biosciences Llc | Antibodies or fusion proteins multimerized via cysteine mutation and a mu tailpiece |
| BR112015002091A2 (pt) | 2012-08-02 | 2017-12-12 | Hoffmann La Roche | método para a produção de um polipeptídeo, polipeptídeo, uso de um polipeptídeo e composição |
| CN104718223A (zh) | 2012-08-20 | 2015-06-17 | 格利克尼克股份有限公司 | 具有抗原结合和多价FCγ受体结合活性的分子 |
| WO2014060712A1 (en) | 2012-10-17 | 2014-04-24 | Liverpool School Of Tropical Medicine | Immunomodulatory proteins |
| RU2016139006A (ru) | 2014-03-05 | 2018-04-05 | Юсб Биофарма Спрл | Мультимерные fc-белки |
| US20170081406A1 (en) | 2014-03-05 | 2017-03-23 | Ucb Biopharma Sprl | Multimeric fc proteins |
| CA2945882A1 (en) | 2014-04-16 | 2015-10-22 | Ucb Biopharma Sprl | Multimeric fc proteins |
| CN113501880A (zh) | 2014-05-02 | 2021-10-15 | 动量制药公司 | 涉及工程化Fc构建体的组合物和方法 |
| AU2016227632A1 (en) | 2015-03-05 | 2017-09-14 | Ucb Biopharma Sprl | Polymeric Fc proteins and methods of screening to alter their functional characteristics |
| GB201511787D0 (en) | 2015-07-06 | 2015-08-19 | Ucb Biopharma Sprl | Proteins |
-
2015
- 2015-03-05 RU RU2016139006A patent/RU2016139006A/ru not_active Application Discontinuation
- 2015-03-05 JP JP2016555527A patent/JP6851200B2/ja not_active Expired - Fee Related
- 2015-03-05 MX MX2016010951A patent/MX2016010951A/es unknown
- 2015-03-05 AU AU2015226100A patent/AU2015226100B2/en not_active Ceased
- 2015-03-05 CA CA2939198A patent/CA2939198A1/en not_active Abandoned
- 2015-03-05 UY UY0001036021A patent/UY36021A/es not_active Application Discontinuation
- 2015-03-05 US US15/123,038 patent/US11352414B2/en active Active
- 2015-03-05 TW TW104107000A patent/TW201619188A/zh unknown
- 2015-03-05 WO PCT/EP2015/054687 patent/WO2015132364A1/en not_active Ceased
- 2015-03-05 SG SG11201606597QA patent/SG11201606597QA/en unknown
- 2015-03-05 BR BR112016020368-2A patent/BR112016020368A2/pt not_active Application Discontinuation
- 2015-03-05 EP EP15708208.2A patent/EP3114143B1/en active Active
- 2015-03-05 CN CN201580011851.9A patent/CN106068274A/zh active Pending
- 2015-03-05 KR KR1020167027642A patent/KR20160130463A/ko not_active Withdrawn
-
2016
- 2016-08-03 IL IL247096A patent/IL247096A0/en unknown
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