JP2017512063A5 - - Google Patents
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- Publication number
- JP2017512063A5 JP2017512063A5 JP2016555527A JP2016555527A JP2017512063A5 JP 2017512063 A5 JP2017512063 A5 JP 2017512063A5 JP 2016555527 A JP2016555527 A JP 2016555527A JP 2016555527 A JP2016555527 A JP 2016555527A JP 2017512063 A5 JP2017512063 A5 JP 2017512063A5
- Authority
- JP
- Japan
- Prior art keywords
- fusion protein
- residue
- multimeric fusion
- region
- heavy chain
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 108020001507 fusion proteins Proteins 0.000 claims 18
- 102000037865 fusion proteins Human genes 0.000 claims 18
- 229920001184 polypeptide Polymers 0.000 claims 8
- 102000004196 processed proteins & peptides Human genes 0.000 claims 8
- 108090000765 processed proteins & peptides Proteins 0.000 claims 8
- 239000000178 monomer Substances 0.000 claims 6
- 125000003607 serino group Chemical group [H]N([H])[C@]([H])(C(=O)[*])C(O[H])([H])[H] 0.000 claims 5
- 125000003295 alanine group Chemical group N[C@@H](C)C(=O)* 0.000 claims 4
- COLNVLDHVKWLRT-QMMMGPOBSA-N phenylalanine group Chemical group N[C@@H](CC1=CC=CC=C1)C(=O)O COLNVLDHVKWLRT-QMMMGPOBSA-N 0.000 claims 4
- 125000001909 leucine group Chemical group [H]N(*)C(C(*)=O)C([H])([H])C(C([H])([H])[H])C([H])([H])[H] 0.000 claims 3
- 125000001500 prolyl group Chemical group [H]N1C([H])(C(=O)[*])C([H])([H])C([H])([H])C1([H])[H] 0.000 claims 3
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 2
- 210000004027 cell Anatomy 0.000 claims 2
- 238000010367 cloning Methods 0.000 claims 2
- 239000013604 expression vector Substances 0.000 claims 2
- 125000003630 glycyl group Chemical group [H]N([H])C([H])([H])C(*)=O 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- WLKSPGHQGFFKGE-UHFFFAOYSA-N 1-chloropropan-2-yl n-(3-chlorophenyl)carbamate Chemical compound ClCC(C)OC(=O)NC1=CC=CC(Cl)=C1 WLKSPGHQGFFKGE-UHFFFAOYSA-N 0.000 claims 1
- 108020004414 DNA Proteins 0.000 claims 1
- 235000001014 amino acid Nutrition 0.000 claims 1
- 125000000539 amino acid group Chemical group 0.000 claims 1
- 150000001413 amino acids Chemical class 0.000 claims 1
- 210000004899 c-terminal region Anatomy 0.000 claims 1
- 239000013599 cloning vector Substances 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 235000018417 cysteine Nutrition 0.000 claims 1
- XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 claims 1
- 125000000151 cysteine group Chemical group N[C@@H](CS)C(=O)* 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 230000004927 fusion Effects 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
- 125000001493 tyrosinyl group Chemical group [H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])(N([H])[H])C(*)=O 0.000 claims 1
Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB1403913.5 | 2014-03-05 | ||
| GB201403913A GB201403913D0 (en) | 2014-03-05 | 2014-03-05 | Proteins |
| GB201403912A GB201403912D0 (en) | 2014-03-05 | 2014-03-05 | Proteins |
| GB1403912.7 | 2014-03-05 | ||
| GB201405952A GB201405952D0 (en) | 2014-04-02 | 2014-04-02 | Proteins |
| GB1405952.1 | 2014-04-02 | ||
| GB1412646.0 | 2014-07-16 | ||
| GB201412646A GB201412646D0 (en) | 2014-07-16 | 2014-07-16 | Proteins |
| PCT/EP2015/054687 WO2015132364A1 (en) | 2014-03-05 | 2015-03-05 | Multimeric fc proteins |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017512063A JP2017512063A (ja) | 2017-05-18 |
| JP2017512063A5 true JP2017512063A5 (enExample) | 2018-04-12 |
| JP6851200B2 JP6851200B2 (ja) | 2021-03-31 |
Family
ID=52629578
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016555527A Expired - Fee Related JP6851200B2 (ja) | 2014-03-05 | 2015-03-05 | 多量体Ｆｃタンパク質 |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US11352414B2 (enExample) |
| EP (1) | EP3114143B1 (enExample) |
| JP (1) | JP6851200B2 (enExample) |
| KR (1) | KR20160130463A (enExample) |
| CN (1) | CN106068274A (enExample) |
| AU (1) | AU2015226100B2 (enExample) |
| BR (1) | BR112016020368A2 (enExample) |
| CA (1) | CA2939198A1 (enExample) |
| IL (1) | IL247096A0 (enExample) |
| MX (1) | MX2016010951A (enExample) |
| RU (1) | RU2016139006A (enExample) |
| SG (1) | SG11201606597QA (enExample) |
| TW (1) | TW201619188A (enExample) |
| UY (1) | UY36021A (enExample) |
| WO (1) | WO2015132364A1 (enExample) |
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106068274A (zh) * | 2014-03-05 | 2016-11-02 | Ucb生物制药私人有限公司 | 多聚体Fc蛋白 |
| SG10201913507SA (en) | 2014-05-02 | 2020-02-27 | Momenta Pharmaceuticals Inc | Compositions and methods related to engineered fc constructs |
| EP3303380B1 (en) | 2015-06-02 | 2020-01-15 | Novo Nordisk A/S | Insulins with polar recombinant extensions |
| GB201511787D0 (en) * | 2015-07-06 | 2015-08-19 | Ucb Biopharma Sprl | Proteins |
| GB201513033D0 (en) * | 2015-07-23 | 2015-09-09 | Ucb Biopharma Sprl | Proteins |
| IL309260B2 (en) | 2015-07-24 | 2025-01-01 | Gliknik Inc | Fusion proteins of human protein fragments to create ordered multimeric immunoglobulin FC preparations with enhanced complement binding |
| WO2017055582A1 (en) | 2015-10-01 | 2017-04-06 | Novo Nordisk A/S | Protein conjugates |
| RU2018130525A (ru) * | 2016-01-27 | 2020-02-27 | Цсл Беринг Ленгнау Аг | РЕКОМБИНАНТНЫЕ Fc-МУЛЬТИМЕРЫ IgG |
| US12391759B2 (en) | 2016-03-02 | 2025-08-19 | Momenta Pharmaceuticals, Inc. | Methods related to engineered Fc constructs |
| GB201607979D0 (en) * | 2016-05-06 | 2016-06-22 | Liverpool School Tropical Medicine | Monomeric proteins and uses thereof |
| IL309293A (en) | 2016-05-23 | 2024-02-01 | Momenta Pharmaceuticals Inc | Compositions and methods relating to engineered FC constructs |
| CA3026420A1 (en) | 2016-06-07 | 2017-12-14 | Gliknik Inc. | Cysteine-optimized stradomers |
| KR20190032392A (ko) * | 2016-07-22 | 2019-03-27 | 글리크닉 인코포레이티드 | 향상된 fc 수용체 결합을 갖는 규칙적으로 다량체화된 면역글로불린 fc 조성물을 생성하기 위한 인간 단백질 단편의 융합 단백질 |
| BR112019009484A2 (pt) | 2016-12-09 | 2019-07-30 | Gliknik Inc | otimização de fabricação de gl-2045, um stradomer multimerizador |
| BR112019009495A2 (pt) | 2016-12-09 | 2019-08-06 | Gliknik Inc | métodos de tratamento de distúrbios inflamatórios com compostos de fc multivalentes |
| CN110650748B (zh) | 2017-01-06 | 2024-01-02 | 动量制药公司 | 与经工程改造的Fc构建体相关的组合物和方法 |
| US12024560B2 (en) | 2017-03-28 | 2024-07-02 | Lyvgen Biopharma Holdings Limited | Therapeutic agents and methods for enhancing immune responses in tumor microenvironment |
| JP2020513019A (ja) | 2017-04-05 | 2020-04-30 | ノヴォ ノルディスク アー／エス | オリゴマー伸長インスリン−Ｆｃコンジュゲート |
| KR101913743B1 (ko) | 2017-04-07 | 2018-11-01 | 국민대학교 산학협력단 | 혈중 반감기 연장을 위한 항체 Fc 변이체들 |
| KR20200014379A (ko) * | 2017-06-05 | 2020-02-10 | 얀센 바이오테크 인코포레이티드 | 비대칭 ch2-ch3 영역 돌연변이를 갖는 조작된 다중특이성 항체 및 다른 다량체 단백질 |
| JP7351835B2 (ja) * | 2017-12-14 | 2023-09-27 | ツェー・エス・エル・ベーリング・レングナウ・アクチエンゲゼルシャフト | 視神経脊髄炎の処置のための組換えＩｇＧ Ｆｃ多量体 |
| AU2019235513B2 (en) * | 2018-03-16 | 2026-01-29 | Liverpool School Of Tropical Medicine | Chimeric Fc receptor binding proteins and uses thereof |
| KR102232659B1 (ko) * | 2018-07-16 | 2021-03-26 | 전북대학교 산학협력단 | 항원전달용 폴리펩타이드, 이를 포함하는 Fc-융합 단백질 및 이의 용도 |
| EP3880248A4 (en) * | 2018-11-14 | 2022-08-10 | JN Biosciences, LLC | MULTIMERIC HYBRID FC PROTEINS FOR IV IG REPLACEMENT |
| AU2020344164A1 (en) | 2019-09-13 | 2022-04-14 | CSL Behring Lengnau AG | Recombinant IgG Fc multimers for the treatment of immune complex-mediated kidney disorders |
| BR112022010096A2 (pt) * | 2019-12-06 | 2022-09-06 | CSL Behring Lengnau AG | Composições estáveis de multímeros fc |
| GB2595299B (en) * | 2020-05-21 | 2022-08-03 | Mabsolve Ltd | Modified immunoglobulin FC regions |
| CN115724985A (zh) * | 2021-08-27 | 2023-03-03 | 三生国健药业（上海）股份有限公司 | 一种cdc平台抗体 |
| WO2023239940A1 (en) * | 2022-06-10 | 2023-12-14 | Research Development Foundation | Engineered fcriib selective igg1 fc variants and uses thereof |
| CN121779581B (zh) * | 2026-03-09 | 2026-06-16 | 华中农业大学 | 长效猫粒细胞巨噬细胞集落刺激因子重组蛋白、及其cho细胞表达方法和应用 |
Family Cites Families (48)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5677425A (en) | 1987-09-04 | 1997-10-14 | Celltech Therapeutics Limited | Recombinant antibody |
| US20020147326A1 (en) * | 1996-06-14 | 2002-10-10 | Smithkline Beecham Corporation | Hexameric fusion proteins and uses therefor |
| US5980898A (en) | 1996-11-14 | 1999-11-09 | The United States Of America As Represented By The U.S. Army Medical Research & Material Command | Adjuvant for transcutaneous immunization |
| GB9625640D0 (en) | 1996-12-10 | 1997-01-29 | Celltech Therapeutics Ltd | Biological products |
| US6114515A (en) | 1997-08-25 | 2000-09-05 | Smithkline Beecham Corporation | PIGRL-1, a member of immunoglobulin gene superfamily |
| GB9720054D0 (en) | 1997-09-19 | 1997-11-19 | Celltech Therapeutics Ltd | Biological products |
| CA2323757C (en) | 1998-04-02 | 2011-08-02 | Genentech, Inc. | Antibody variants and fragments thereof |
| AU3655899A (en) | 1998-04-20 | 1999-11-08 | Regents Of The University Of California, The | Modified immunoglobulin molecules and methods for use thereof |
| US6737056B1 (en) * | 1999-01-15 | 2004-05-18 | Genentech, Inc. | Polypeptide variants with altered effector function |
| MY129566A (en) | 1999-01-19 | 2007-04-30 | Nestle Sa | A hypoallergenic composition containing tolerogenic peptides inducing oral tolerance |
| US6475749B1 (en) | 1999-08-11 | 2002-11-05 | The Regents Of The University Of California | Rh hybrid antibody |
| DE10001372A1 (de) | 2000-01-14 | 2001-08-02 | Deutsches Krebsforsch | Anti-CD3-Einzelketten-Antikörper mit humanem Cmu3- und Cmu4- Domänen |
| DK1366067T3 (da) | 2001-03-07 | 2012-10-22 | Merck Patent Gmbh | Ekspressionsteknologi for proteiner indeholdende en hybrid isotype-antistof-enhed |
| KR100453877B1 (ko) | 2001-07-26 | 2004-10-20 | 메덱스젠 주식회사 | 연쇄체화에 의한 면역 글로블린 융합 단백질의 제조 방법 및 이 방법에 의해 제조된 ＴＮＦＲ/Ｆｃ 융합 단백질, 상기 단백질을 코딩하는 ＤＮＡ, 상기 ＤＮＡ를 포함하는벡터, 및 상기 벡터에 의한 형질전환체 |
| US20040132101A1 (en) | 2002-09-27 | 2004-07-08 | Xencor | Optimized Fc variants and methods for their generation |
| US7317091B2 (en) | 2002-03-01 | 2008-01-08 | Xencor, Inc. | Optimized Fc variants |
| CA2832136C (en) | 2002-09-27 | 2015-11-17 | Xencor | Optimized fc variants and methods for their generation |
| US8388955B2 (en) * | 2003-03-03 | 2013-03-05 | Xencor, Inc. | Fc variants |
| PT1644412E (pt) | 2003-07-01 | 2015-12-23 | Ucb Biopharma Sprl | Fragmentos de anticorpos fab modificados |
| GB0315457D0 (en) | 2003-07-01 | 2003-08-06 | Celltech R&D Ltd | Biological products |
| GB0315450D0 (en) | 2003-07-01 | 2003-08-06 | Celltech R&D Ltd | Biological products |
| US20060134105A1 (en) | 2004-10-21 | 2006-06-22 | Xencor, Inc. | IgG immunoglobulin variants with optimized effector function |
| WO2005063815A2 (en) | 2003-11-12 | 2005-07-14 | Biogen Idec Ma Inc. | Fcϝ receptor-binding polypeptide variants and methods related thereto |
| EP3342782B1 (en) | 2004-07-15 | 2022-08-17 | Xencor, Inc. | Optimized fc variants |
| CN105837690A (zh) | 2006-06-12 | 2016-08-10 | 新兴产品开发西雅图有限公司 | 具有效应功能的单链多价结合蛋白 |
| US20100297103A1 (en) | 2006-09-14 | 2010-11-25 | Medical & Biological Laboratories Co., Ltd. | Antibody having enhanced adcc activity and method for production thereof |
| MX2009012343A (es) | 2007-05-14 | 2010-02-10 | Biogen Idec Inc | Regiones fc (sc fc) de cadena sencilla, polipeptidos de enlace que comprenden las mismas, y metodos relacionados con ello. |
| SI2185589T1 (sl) * | 2007-06-01 | 2016-04-29 | University Of Maryland Baltimore | Vezavna sredstva za Fc receptor konstantne regije imunoglobulina |
| MX2010010027A (es) * | 2008-03-13 | 2011-05-02 | Biotest Ag | Agente para tratar enfermedad. |
| JP2012515556A (ja) | 2009-01-23 | 2012-07-12 | バイオジェン・アイデック・エムエイ・インコーポレイテッド | 低下したエフェクタ機能を有する安定化Ｆｃポリペプチドおよび使用方法 |
| CN102781963B (zh) | 2009-10-27 | 2018-02-16 | Ucb医药有限公司 | 功能修饰性NAv1.7抗体 |
| GB0922209D0 (en) * | 2009-12-18 | 2010-02-03 | Univ Nottingham | Proteins, nucleic acid molecules and compositions |
| WO2012016073A2 (en) | 2010-07-28 | 2012-02-02 | Gliknik Inc. | Fusion proteins of natural human protein fragments to create orderly multimerized immunoglobulin fc compositions |
| UA117901C2 (uk) | 2011-07-06 | 2018-10-25 | Ґенмаб Б.В. | Спосіб посилення ефекторної функції вихідного поліпептиду, його варіанти та їх застосування |
| EP2760891B1 (en) * | 2011-09-26 | 2018-11-07 | JN Biosciences LLC | Hybrid constant regions |
| WO2013096221A1 (en) | 2011-12-21 | 2013-06-27 | Amgen Inc. | Variant fc-polypeptides with enhanced binding to the neonatal fc receptor |
| KR102041412B1 (ko) | 2011-12-30 | 2019-11-11 | 한미사이언스 주식회사 | 면역글로불린 Ｆｃ 단편 유도체 |
| WO2014006217A1 (en) | 2012-07-06 | 2014-01-09 | Genmab B.V. | Dimeric protein with triple mutations |
| SG11201408530YA (en) | 2012-08-02 | 2015-03-30 | Hoffmann La Roche | Method for producing monomeric and multimeric molecules and uses thereof |
| CA2879814A1 (en) * | 2012-08-02 | 2014-02-06 | Jn Biosciences Llc | Antibodies or fusion proteins multimerized via cysteine mutation and a mu tailpiece |
| KR20150058236A (ko) | 2012-08-20 | 2015-05-28 | 글리크닉 인코포레이티드 | 항원 결합 및 다가 fc 감마 수용체 결합 활성을 가진 분자 |
| CA2888519C (en) | 2012-10-17 | 2023-02-21 | Liverpool School Of Tropical Medicine | Immunomodulatory proteins |
| CN106068274A (zh) * | 2014-03-05 | 2016-11-02 | Ucb生物制药私人有限公司 | 多聚体Fc蛋白 |
| CN106132994A (zh) | 2014-03-05 | 2016-11-16 | Ucb生物制药私人有限公司 | 多聚体Fc蛋白 |
| JP2017513481A (ja) | 2014-04-16 | 2017-06-01 | ユーシービー バイオファルマ エスピーアールエル | 多量体Ｆｃタンパク質 |
| SG10201913507SA (en) | 2014-05-02 | 2020-02-27 | Momenta Pharmaceuticals Inc | Compositions and methods related to engineered fc constructs |
| CA2978501A1 (en) | 2015-03-05 | 2016-09-09 | Ucb Biopharma Sprl | Polymeric fc proteins and methods of screening to alter their functional characteristics |
| GB201511787D0 (en) | 2015-07-06 | 2015-08-19 | Ucb Biopharma Sprl | Proteins |
-
2015
- 2015-03-05 CN CN201580011851.9A patent/CN106068274A/zh active Pending
- 2015-03-05 CA CA2939198A patent/CA2939198A1/en not_active Abandoned
- 2015-03-05 US US15/123,038 patent/US11352414B2/en not_active Expired - Fee Related
- 2015-03-05 MX MX2016010951A patent/MX2016010951A/es unknown
- 2015-03-05 UY UY0001036021A patent/UY36021A/es not_active Application Discontinuation
- 2015-03-05 BR BR112016020368-2A patent/BR112016020368A2/pt not_active Application Discontinuation
- 2015-03-05 KR KR1020167027642A patent/KR20160130463A/ko not_active Withdrawn
- 2015-03-05 SG SG11201606597QA patent/SG11201606597QA/en unknown
- 2015-03-05 EP EP15708208.2A patent/EP3114143B1/en active Active
- 2015-03-05 TW TW104107000A patent/TW201619188A/zh unknown
- 2015-03-05 AU AU2015226100A patent/AU2015226100B2/en not_active Ceased
- 2015-03-05 JP JP2016555527A patent/JP6851200B2/ja not_active Expired - Fee Related
- 2015-03-05 RU RU2016139006A patent/RU2016139006A/ru not_active Application Discontinuation
- 2015-03-05 WO PCT/EP2015/054687 patent/WO2015132364A1/en not_active Ceased
-
2016
- 2016-08-03 IL IL247096A patent/IL247096A0/en unknown
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