JP2016525100A5 - - Google Patents
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- Publication number
- JP2016525100A5 JP2016525100A5 JP2016525330A JP2016525330A JP2016525100A5 JP 2016525100 A5 JP2016525100 A5 JP 2016525100A5 JP 2016525330 A JP2016525330 A JP 2016525330A JP 2016525330 A JP2016525330 A JP 2016525330A JP 2016525100 A5 JP2016525100 A5 JP 2016525100A5
- Authority
- JP
- Japan
- Prior art keywords
- amino acid
- glutamine
- residue
- mutated
- asparagine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- ZDXPYRJPNDTMRX-UHFFFAOYSA-N glutamine Natural products OC(=O)C(N)CCC(N)=O ZDXPYRJPNDTMRX-UHFFFAOYSA-N 0.000 claims 19
- 235000004554 glutamine Nutrition 0.000 claims 19
- 229940024606 amino acid Drugs 0.000 claims 15
- 235000001014 amino acid Nutrition 0.000 claims 15
- 125000000539 amino acid group Chemical group 0.000 claims 15
- 150000001413 amino acids Chemical class 0.000 claims 15
- DCXYFEDJOCDNAF-UHFFFAOYSA-N Asparagine Natural products OC(=O)C(N)CC(N)=O DCXYFEDJOCDNAF-UHFFFAOYSA-N 0.000 claims 13
- XUJNEKJLAYXESH-REOHCLBHSA-N L-Cysteine Chemical compound SC[C@H](N)C(O)=O XUJNEKJLAYXESH-REOHCLBHSA-N 0.000 claims 13
- ONIBWKKTOPOVIA-BYPYZUCNSA-N L-Proline Chemical compound OC(=O)[C@@H]1CCCN1 ONIBWKKTOPOVIA-BYPYZUCNSA-N 0.000 claims 13
- DCXYFEDJOCDNAF-REOHCLBHSA-N L-asparagine Chemical compound OC(=O)[C@@H](N)CC(N)=O DCXYFEDJOCDNAF-REOHCLBHSA-N 0.000 claims 13
- ZDXPYRJPNDTMRX-VKHMYHEASA-N L-glutamine Chemical compound OC(=O)[C@@H](N)CCC(N)=O ZDXPYRJPNDTMRX-VKHMYHEASA-N 0.000 claims 13
- ONIBWKKTOPOVIA-UHFFFAOYSA-N Proline Natural products OC(=O)C1CCCN1 ONIBWKKTOPOVIA-UHFFFAOYSA-N 0.000 claims 13
- 235000009582 asparagine Nutrition 0.000 claims 13
- 229960001230 asparagine Drugs 0.000 claims 13
- 235000018417 cysteine Nutrition 0.000 claims 13
- XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 claims 13
- 235000013930 proline Nutrition 0.000 claims 13
- 229920001184 polypeptide Polymers 0.000 claims 11
- 102000004196 processed proteins & peptides Human genes 0.000 claims 11
- 108090000765 processed proteins & peptides Proteins 0.000 claims 11
- QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical compound C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 claims 9
- 235000004279 alanine Nutrition 0.000 claims 9
- 125000000404 glutamine group Chemical group N[C@@H](CCC(N)=O)C(=O)* 0.000 claims 8
- 239000011159 matrix material Substances 0.000 claims 6
- 238000000926 separation method Methods 0.000 claims 6
- CKLJMWTZIZZHCS-REOHCLBHSA-N L-aspartic acid Chemical compound OC(=O)[C@@H](N)CC(O)=O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 claims 5
- WHUUTDBJXJRKMK-UHFFFAOYSA-N Glutamic acid Natural products OC(=O)C(N)CCC(O)=O WHUUTDBJXJRKMK-UHFFFAOYSA-N 0.000 claims 3
- 108060003951 Immunoglobulin Proteins 0.000 claims 3
- AYFVYJQAPQTCCC-GBXIJSLDSA-N L-threonine Chemical compound C[C@@H](O)[C@H](N)C(O)=O AYFVYJQAPQTCCC-GBXIJSLDSA-N 0.000 claims 3
- 239000004472 Lysine Substances 0.000 claims 3
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 claims 3
- AYFVYJQAPQTCCC-UHFFFAOYSA-N Threonine Natural products CC(O)C(N)C(O)=O AYFVYJQAPQTCCC-UHFFFAOYSA-N 0.000 claims 3
- 239000004473 Threonine Substances 0.000 claims 3
- 235000003704 aspartic acid Nutrition 0.000 claims 3
- OQFSQFPPLPISGP-UHFFFAOYSA-N beta-carboxyaspartic acid Natural products OC(=O)C(N)C(C(O)=O)C(O)=O OQFSQFPPLPISGP-UHFFFAOYSA-N 0.000 claims 3
- 238000004140 cleaning Methods 0.000 claims 3
- -1 for example Chemical compound 0.000 claims 3
- 235000013922 glutamic acid Nutrition 0.000 claims 3
- 239000004220 glutamic acid Substances 0.000 claims 3
- 125000000291 glutamic acid group Chemical group N[C@@H](CCC(O)=O)C(=O)* 0.000 claims 3
- 102000018358 immunoglobulin Human genes 0.000 claims 3
- 239000007788 liquid Substances 0.000 claims 3
- 238000000034 method Methods 0.000 claims 3
- MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 claims 2
- 108010088160 Staphylococcal Protein A Proteins 0.000 claims 2
- 230000035772 mutation Effects 0.000 claims 2
- 235000004400 serine Nutrition 0.000 claims 2
- 238000005406 washing Methods 0.000 claims 2
- MTCFGRXMJLQNBG-REOHCLBHSA-N (2S)-2-Amino-3-hydroxypropansäure Chemical compound OC[C@H](N)C(O)=O MTCFGRXMJLQNBG-REOHCLBHSA-N 0.000 claims 1
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
- 241001481833 Coryphaena hippurus Species 0.000 claims 1
- WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 claims 1
- KZSNJWFQEVHDMF-BYPYZUCNSA-N L-valine Chemical compound CC(C)[C@H](N)C(O)=O KZSNJWFQEVHDMF-BYPYZUCNSA-N 0.000 claims 1
- KZSNJWFQEVHDMF-UHFFFAOYSA-N Valine Natural products CC(C)C(N)C(O)=O KZSNJWFQEVHDMF-UHFFFAOYSA-N 0.000 claims 1
- 239000003513 alkali Substances 0.000 claims 1
- 125000000613 asparagine group Chemical group N[C@@H](CC(N)=O)C(=O)* 0.000 claims 1
- 229940072221 immunoglobulins Drugs 0.000 claims 1
- 108010025221 plasma protein Z Proteins 0.000 claims 1
- 230000009145 protein modification Effects 0.000 claims 1
- 102220248493 rs1555542879 Human genes 0.000 claims 1
- 125000003607 serino group Chemical group [H]N([H])[C@]([H])(C(=O)[*])C(O[H])([H])[H] 0.000 claims 1
- 239000007787 solid Substances 0.000 claims 1
- 239000004474 valine Substances 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE1350859 | 2013-07-10 | ||
| SE1350860-1 | 2013-07-10 | ||
| SE1350859-3 | 2013-07-10 | ||
| SE1350860 | 2013-07-10 | ||
| PCT/SE2014/050882 WO2015005862A1 (en) | 2013-07-10 | 2014-07-10 | Mutated immunoglobulin-binding polypeptides |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016525100A JP2016525100A (ja) | 2016-08-22 |
| JP2016525100A5 true JP2016525100A5 (enExample) | 2017-08-17 |
| JP6544809B2 JP6544809B2 (ja) | 2019-07-17 |
Family
ID=52280382
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016525329A Active JP6544808B2 (ja) | 2013-07-10 | 2014-07-08 | 突然変異免疫グロブリン結合ポリペプチド |
| JP2016525330A Active JP6544809B2 (ja) | 2013-07-10 | 2014-07-10 | 突然変異免疫グロブリン結合ポリペプチド |
| JP2019109474A Active JP6862008B2 (ja) | 2013-07-10 | 2019-06-12 | 突然変異免疫グロブリン結合ポリペプチド |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016525329A Active JP6544808B2 (ja) | 2013-07-10 | 2014-07-08 | 突然変異免疫グロブリン結合ポリペプチド |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019109474A Active JP6862008B2 (ja) | 2013-07-10 | 2019-06-12 | 突然変異免疫グロブリン結合ポリペプチド |
Country Status (5)
| Country | Link |
|---|---|
| US (5) | US9896486B2 (enExample) |
| EP (2) | EP3019520B1 (enExample) |
| JP (3) | JP6544808B2 (enExample) |
| CN (3) | CN111848755A (enExample) |
| WO (2) | WO2015005859A1 (enExample) |
Families Citing this family (56)
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|---|---|---|---|---|
| SE0200943D0 (sv) * | 2002-03-25 | 2002-03-25 | Amersham Biosciences Ab | Mutant protein |
| EP3019520B1 (en) | 2013-07-10 | 2019-12-11 | GE Healthcare BioProcess R&D AB | Mutated immunoglobulin-binding polypeptides |
| NZ758065A (en) | 2013-10-22 | 2022-08-26 | Nuvoda Llc | Reduction of substances in contaminated fluids using a naturally occurring biological growth media |
| US11566082B2 (en) * | 2014-11-17 | 2023-01-31 | Cytiva Bioprocess R&D Ab | Mutated immunoglobulin-binding polypeptides |
| WO2016152946A1 (ja) * | 2015-03-26 | 2016-09-29 | Jsr株式会社 | イムノグロブリン結合タンパク質およびそれを用いたアフィニティー担体 |
| JP6588535B2 (ja) | 2015-04-13 | 2019-10-09 | 富士フイルム株式会社 | 短鎖ペプチド固定化担体の製造方法および短鎖ペプチド固定化担体 |
| CN107849088A (zh) * | 2015-07-22 | 2018-03-27 | 株式会社钟化 | 抗体样蛋白质的纯化方法 |
| EP3327029A4 (en) * | 2015-07-22 | 2018-10-31 | Kaneka Corporation | ANTIBODY-BINDING PROTEIN HAVING REDUCED ANTIBODY-BINDING CAPACITY IN ACIDIC pH REGIONS |
| EP3330706B1 (en) * | 2015-07-28 | 2023-03-15 | JSR Corporation | Affinity support and its use in a method for isolating immunoglobulin |
| JPWO2017022672A1 (ja) * | 2015-07-31 | 2018-07-05 | 株式会社カネカ | 免疫グロブリン結合性改変型タンパク質 |
| WO2017022759A1 (ja) * | 2015-08-04 | 2017-02-09 | 株式会社カネカ | 免疫グロブリン結合性改変型タンパク質 |
| GB201515339D0 (en) * | 2015-08-28 | 2015-10-14 | Ge Healthcare Bio Sciences Ab | A seperation matrix and a method of seperating antibodies |
| US10703774B2 (en) | 2016-09-30 | 2020-07-07 | Ge Healthcare Bioprocess R&D Ab | Separation method |
| JP7031934B2 (ja) | 2016-05-11 | 2022-03-08 | サイティバ・バイオプロセス・アールアンドディ・アクチボラグ | 分離マトリックス |
| US10654887B2 (en) | 2016-05-11 | 2020-05-19 | Ge Healthcare Bio-Process R&D Ab | Separation matrix |
| US10730908B2 (en) * | 2016-05-11 | 2020-08-04 | Ge Healthcare Bioprocess R&D Ab | Separation method |
| DK3455244T3 (da) * | 2016-05-11 | 2022-06-07 | Cytiva Bioprocess R & D Ab | Muterede immunoglobulin-bindende polypeptider |
| US11753438B2 (en) | 2016-05-11 | 2023-09-12 | Cytiva Bioprocess R&D Ab | Method of cleaning and/or sanitizing a separation matrix |
| WO2017194594A1 (en) * | 2016-05-11 | 2017-11-16 | Ge Healthcare Bioprocess R&D Ab | Separation method |
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| US11708390B2 (en) | 2016-05-11 | 2023-07-25 | Cytiva Bioprocess R&D Ab | Method of storing a separation matrix |
| US10889615B2 (en) | 2016-05-11 | 2021-01-12 | Cytiva Bioprocess R&D Ab | Mutated immunoglobulin-binding polypeptides |
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| US12448411B2 (en) | 2016-09-30 | 2025-10-21 | Cytiva Bioprocess R&D Ab | Separation method |
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| GB201703116D0 (en) * | 2017-02-27 | 2017-04-12 | Ge Healthcare Bioprocess R&D Ab | A seperation matrix and a method of seperating antibodies |
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| EP3546476A1 (en) * | 2018-03-26 | 2019-10-02 | Repligen Corporation | Fc binding proteins with cysteine in the c-terminal helical region |
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| US12180581B2 (en) | 2017-09-18 | 2024-12-31 | Waters Technologies Corporation | Use of vapor deposition coated flow paths for improved chromatography of metal interacting analytes |
| US11709156B2 (en) | 2017-09-18 | 2023-07-25 | Waters Technologies Corporation | Use of vapor deposition coated flow paths for improved analytical analysis |
| US12181452B2 (en) | 2017-09-18 | 2024-12-31 | Waters Technologies Corporation | Use of vapor deposition coated flow paths for improved chromatography of metal interacting analytes |
| US11709155B2 (en) | 2017-09-18 | 2023-07-25 | Waters Technologies Corporation | Use of vapor deposition coated flow paths for improved chromatography of metal interacting analytes |
| EP3842536A4 (en) * | 2018-08-24 | 2023-01-18 | JSR Corporation | IMMUNOGLOBULIN BINDING PROTEIN AND AFFINITY SUPPORT USING THE SAME |
| GB201904125D0 (en) | 2019-03-26 | 2019-05-08 | Ge Healthcare Bio Sciences Ab | Method for sanitization of a chromatography column |
| JP6927247B2 (ja) * | 2019-04-08 | 2021-08-25 | 昭和電工マテリアルズ株式会社 | 抗体の精製方法 |
| JP7432813B2 (ja) * | 2019-09-10 | 2024-02-19 | 東ソー株式会社 | 免疫グロブリン結合性タンパク質 |
| CN111057153B (zh) | 2019-12-06 | 2021-09-07 | 广州康盛生物科技股份有限公司 | 一种免疫球蛋白结合蛋白及其制备方法和应用 |
| US11918936B2 (en) | 2020-01-17 | 2024-03-05 | Waters Technologies Corporation | Performance and dynamic range for oligonucleotide bioanalysis through reduction of non specific binding |
| CN111732642B (zh) * | 2020-07-30 | 2020-12-04 | 苏州纳微科技股份有限公司 | 免疫球蛋白结合蛋白及其应用 |
| EP4217730B1 (en) | 2020-09-24 | 2025-08-20 | Waters Technologies Corporation | Chromatographic hardware improvements for the separation of reactive molecules |
| WO2022081779A1 (en) | 2020-10-13 | 2022-04-21 | Avitide LLC | Affinity ligand libraries of three-helix bundle proteins and uses thereof |
| CN116670150A (zh) * | 2020-12-22 | 2023-08-29 | 普罗泰纳瓦株式会社 | 免疫球蛋白结合多肽 |
| EP4294542A1 (en) | 2021-02-19 | 2023-12-27 | Avitide LLC | Aav2 affinity agents |
| GB202113626D0 (en) | 2021-09-24 | 2021-11-10 | Cytiva Bioprocess R & D Ab | FC binding polypeptides |
| CN114149495A (zh) * | 2021-12-17 | 2022-03-08 | 博格隆(上海)生物技术有限公司 | 突变的蛋白a结构域c及其应用 |
| CN114315996B (zh) * | 2021-12-31 | 2023-01-17 | 博格隆(浙江)生物技术有限公司 | 一种重组ProteinA蛋白及亲和层析介质的制备方法 |
| CN114409748A (zh) * | 2022-01-28 | 2022-04-29 | 博格隆(浙江)生物技术有限公司 | 蛋白a的b结构域和z结构域突变体及其应用 |
| GB202203478D0 (en) | 2022-03-14 | 2022-04-27 | Cytiva Bioprocess R & D Ab | Vh3 binding polypeptides |
| CN115850408A (zh) * | 2022-09-01 | 2023-03-28 | 西安蓝晓科技新材料股份有限公司 | 一种多肽、融合型多聚体蛋白质及其用途 |
| CN117700501A (zh) * | 2022-09-13 | 2024-03-15 | 普米斯生物技术(珠海)有限公司 | 免疫球蛋白结合蛋白及其应用 |
| CN116217680B (zh) * | 2023-01-10 | 2024-02-02 | 珠海冀百康生物科技有限公司 | 碱稳定性高的免疫球蛋白结合蛋白及其应用 |
| CN116333056A (zh) * | 2023-02-09 | 2023-06-27 | 西宝生物科技（上海）股份有限公司 | 一种高结合容量的耐碱重组Protein A及其制备方法和应用 |
| CN119708176B (zh) * | 2024-12-05 | 2026-01-06 | 武汉瑞法医疗器械有限公司 | 一种多肽、多聚体及其在免疫球蛋白亲和配体中的应用 |
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| EP3019520B1 (en) | 2013-07-10 | 2019-12-11 | GE Healthcare BioProcess R&D AB | Mutated immunoglobulin-binding polypeptides |
-
2014
- 2014-07-08 EP EP14823829.8A patent/EP3019520B1/en active Active
- 2014-07-08 CN CN202010728898.XA patent/CN111848755A/zh active Pending
- 2014-07-08 CN CN201480039292.8A patent/CN105377880B/zh active Active
- 2014-07-08 JP JP2016525329A patent/JP6544808B2/ja active Active
- 2014-07-08 US US14/903,837 patent/US9896486B2/en active Active
- 2014-07-08 WO PCT/SE2014/050872 patent/WO2015005859A1/en not_active Ceased
- 2014-07-10 CN CN201480039299.XA patent/CN105377881B/zh active Active
- 2014-07-10 JP JP2016525330A patent/JP6544809B2/ja active Active
- 2014-07-10 EP EP14823321.6A patent/EP3019519B1/en active Active
- 2014-07-10 WO PCT/SE2014/050882 patent/WO2015005862A1/en not_active Ceased
- 2014-07-10 US US14/904,077 patent/US9663558B2/en active Active
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2015
- 2015-12-07 US US14/961,164 patent/US10308690B2/en active Active
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