|
FR901228A
(fr)
|
1943-01-16 |
1945-07-20 |
Deutsche Edelstahlwerke Ag |
Système d'aimant à entrefer annulaire
|
|
US4816567A
(en)
|
1983-04-08 |
1989-03-28 |
Genentech, Inc. |
Recombinant immunoglobin preparations
|
|
US4943533A
(en)
|
1984-03-01 |
1990-07-24 |
The Regents Of The University Of California |
Hybrid cell lines that produce monoclonal antibodies to epidermal growth factor receptor
|
|
US6548640B1
(en)
|
1986-03-27 |
2003-04-15 |
Btg International Limited |
Altered antibodies
|
|
GB8607679D0
(en)
|
1986-03-27 |
1986-04-30 |
Winter G P |
Recombinant dna product
|
|
US5225539A
(en)
|
1986-03-27 |
1993-07-06 |
Medical Research Council |
Recombinant altered antibodies and methods of making altered antibodies
|
|
US6905680B2
(en)
|
1988-11-23 |
2005-06-14 |
Genetics Institute, Inc. |
Methods of treating HIV infected subjects
|
|
US6534055B1
(en)
|
1988-11-23 |
2003-03-18 |
Genetics Institute, Inc. |
Methods for selectively stimulating proliferation of T cells
|
|
US6352694B1
(en)
|
1994-06-03 |
2002-03-05 |
Genetics Institute, Inc. |
Methods for inducing a population of T cells to proliferate using agents which recognize TCR/CD3 and ligands which stimulate an accessory molecule on the surface of the T cells
|
|
US5858358A
(en)
|
1992-04-07 |
1999-01-12 |
The United States Of America As Represented By The Secretary Of The Navy |
Methods for selectively stimulating proliferation of T cells
|
|
US5530101A
(en)
|
1988-12-28 |
1996-06-25 |
Protein Design Labs, Inc. |
Humanized immunoglobulins
|
|
US5703055A
(en)
|
1989-03-21 |
1997-12-30 |
Wisconsin Alumni Research Foundation |
Generation of antibodies through lipid mediated DNA delivery
|
|
US5399346A
(en)
|
1989-06-14 |
1995-03-21 |
The United States Of America As Represented By The Department Of Health And Human Services |
Gene therapy
|
|
US5585362A
(en)
|
1989-08-22 |
1996-12-17 |
The Regents Of The University Of Michigan |
Adenovirus vectors for gene therapy
|
|
US5859205A
(en)
|
1989-12-21 |
1999-01-12 |
Celltech Limited |
Humanised antibodies
|
|
GB8928874D0
(en)
|
1989-12-21 |
1990-02-28 |
Celltech Ltd |
Humanised antibodies
|
|
US5061620A
(en)
|
1990-03-30 |
1991-10-29 |
Systemix, Inc. |
Human hematopoietic stem cell
|
|
DE69233482T2
(de)
|
1991-05-17 |
2006-01-12 |
Merck & Co., Inc. |
Verfahren zur Verminderung der Immunogenität der variablen Antikörperdomänen
|
|
US5199942A
(en)
|
1991-06-07 |
1993-04-06 |
Immunex Corporation |
Method for improving autologous transplantation
|
|
EP0590058B1
(en)
|
1991-06-14 |
2003-11-26 |
Genentech, Inc. |
HUMANIZED Heregulin ANTIBODy
|
|
US5565332A
(en)
|
1991-09-23 |
1996-10-15 |
Medical Research Council |
Production of chimeric antibodies - a combinatorial approach
|
|
WO1993007105A1
(en)
|
1991-10-04 |
1993-04-15 |
Iit Research Institute |
Conversion of plastic waste to useful oils
|
|
GB9125768D0
(en)
|
1991-12-04 |
1992-02-05 |
Hale Geoffrey |
Therapeutic method
|
|
DE69233204T2
(de)
|
1991-12-13 |
2004-07-15 |
Xoma Corp., Berkeley |
Verfahren und materialien zur herstellung von modifizierten variablen antikörperdomänen und ihre therapeutische verwendung
|
|
EP0656946B2
(en)
|
1992-08-21 |
2010-03-31 |
Vrije Universiteit Brussel |
Immunoglobulins devoid of light chains
|
|
US6005079A
(en)
|
1992-08-21 |
1999-12-21 |
Vrije Universiteit Brussels |
Immunoglobulins devoid of light chains
|
|
US5350674A
(en)
|
1992-09-04 |
1994-09-27 |
Becton, Dickinson And Company |
Intrinsic factor - horse peroxidase conjugates and a method for increasing the stability thereof
|
|
US5639641A
(en)
|
1992-09-09 |
1997-06-17 |
Immunogen Inc. |
Resurfacing of rodent antibodies
|
|
HU221001B1
(hu)
|
1994-03-17 |
2002-07-29 |
Merck Patent Gmbh. |
Egyláncú anti-EGFR Fv-k és anti-EGFR ellenanyagok
|
|
US7175843B2
(en)
|
1994-06-03 |
2007-02-13 |
Genetics Institute, Llc |
Methods for selectively stimulating proliferation of T cells
|
|
US5731168A
(en)
|
1995-03-01 |
1998-03-24 |
Genentech, Inc. |
Method for making heteromultimeric polypeptides
|
|
US6692964B1
(en)
|
1995-05-04 |
2004-02-17 |
The United States Of America As Represented By The Secretary Of The Navy |
Methods for transfecting T cells
|
|
US7067318B2
(en)
|
1995-06-07 |
2006-06-27 |
The Regents Of The University Of Michigan |
Methods for transfecting T cells
|
|
US5773292A
(en)
|
1995-06-05 |
1998-06-30 |
Cornell University |
Antibodies binding portions, and probes recognizing an antigen of prostate epithelial cells but not antigens circulating in the blood
|
|
US7060808B1
(en)
|
1995-06-07 |
2006-06-13 |
Imclone Systems Incorporated |
Humanized anti-EGF receptor monoclonal antibody
|
|
US6136311A
(en)
|
1996-05-06 |
2000-10-24 |
Cornell Research Foundation, Inc. |
Treatment and diagnosis of cancer
|
|
US6107090A
(en)
|
1996-05-06 |
2000-08-22 |
Cornell Research Foundation, Inc. |
Treatment and diagnosis of prostate cancer with antibodies to extracellur PSMA domains
|
|
ES2176574T3
(es)
|
1996-09-03 |
2002-12-01 |
Gsf Forschungszentrum Umwelt |
Utilizacion de anticuerpos bi y triespecificos para la induccion de inmunidad tumoral.
|
|
BR9813276A
(pt)
|
1997-10-27 |
2000-08-22 |
Unilever Nv |
Proteìna multivalente de ligação de antìgeno, sequências de nucleotìdeos, vetor de expressão, célula hospedeira, processo para preparação de proteìna multivalente de ligação de antìgeno, e, uso da mesma
|
|
WO1999037681A2
(en)
|
1998-01-26 |
1999-07-29 |
Unilever Plc |
Method for producing antibody fragments
|
|
CZ121599A3
(cs)
|
1998-04-09 |
1999-10-13 |
Aventis Pharma Deutschland Gmbh |
Jednořetězcová molekula vázající několik antigenů, způsob její přípravy a léčivo obsahující tuto molekulu
|
|
WO2000043507A1
(en)
|
1999-01-19 |
2000-07-27 |
Unilever Plc |
Method for producing antibody fragments
|
|
US6326193B1
(en)
|
1999-11-05 |
2001-12-04 |
Cambria Biosciences, Llc |
Insect control agent
|
|
US20060228364A1
(en)
|
1999-12-24 |
2006-10-12 |
Genentech, Inc. |
Serum albumin binding peptides for tumor targeting
|
|
US7572631B2
(en)
|
2000-02-24 |
2009-08-11 |
Invitrogen Corporation |
Activation and expansion of T cells
|
|
US6797514B2
(en)
|
2000-02-24 |
2004-09-28 |
Xcyte Therapies, Inc. |
Simultaneous stimulation and concentration of cells
|
|
US6867041B2
(en)
|
2000-02-24 |
2005-03-15 |
Xcyte Therapies, Inc. |
Simultaneous stimulation and concentration of cells
|
|
DK1257632T3
(da)
|
2000-02-24 |
2008-01-28 |
Xcyte Therapies Inc |
Samtidig stimulering og opkoncentrering af celler
|
|
US20030190598A1
(en)
|
2000-05-26 |
2003-10-09 |
Jasmid Tanha |
Single-domain antigen-binding antibody fragments derived from llama antibodies
|
|
AU2001275474A1
(en)
|
2000-06-12 |
2001-12-24 |
Akkadix Corporation |
Materials and methods for the control of nematodes
|
|
CN1294148C
(zh)
|
2001-04-11 |
2007-01-10 |
中国科学院遗传与发育生物学研究所 |
环状单链三特异抗体
|
|
GB0110029D0
(en)
|
2001-04-24 |
2001-06-13 |
Grosveld Frank |
Transgenic animal
|
|
CN1195779C
(zh)
|
2001-05-24 |
2005-04-06 |
中国科学院遗传与发育生物学研究所 |
抗人卵巢癌抗人cd3双特异性抗体
|
|
US7666414B2
(en)
|
2001-06-01 |
2010-02-23 |
Cornell Research Foundation, Inc. |
Methods for treating prostate cancer using modified antibodies to prostate-specific membrane antigen
|
|
CZ200438A3
(cs)
|
2001-06-13 |
2004-06-16 |
Genmab A/S |
Název neuveden
|
|
US7595378B2
(en)
|
2001-06-13 |
2009-09-29 |
Genmab A/S |
Human monoclonal antibodies to epidermal growth factor receptor (EGFR)
|
|
JP4213586B2
(ja)
|
2001-09-13 |
2009-01-21 |
株式会社抗体研究所 |
ラクダ抗体ライブラリーの作製方法
|
|
ES2606537T3
(es)
|
2001-10-23 |
2017-03-24 |
Psma Development Company L.L.C. |
Anticuerpos contra PSMA
|
|
US20050215472A1
(en)
|
2001-10-23 |
2005-09-29 |
Psma Development Company, Llc |
PSMA formulations and uses thereof
|
|
JP2005289809A
(ja)
|
2001-10-24 |
2005-10-20 |
Vlaams Interuniversitair Inst Voor Biotechnologie Vzw (Vib Vzw) |
突然変異重鎖抗体
|
|
US7745140B2
(en)
|
2002-01-03 |
2010-06-29 |
The Trustees Of The University Of Pennsylvania |
Activation and expansion of T-cells using an engineered multivalent signaling platform as a research tool
|
|
CN1652821A
(zh)
|
2002-01-28 |
2005-08-10 |
米德列斯公司 |
抗前列腺特异性膜抗原(psma)的人单克隆抗体
|
|
US20040132101A1
(en)
|
2002-09-27 |
2004-07-08 |
Xencor |
Optimized Fc variants and methods for their generation
|
|
DK1517921T3
(da)
|
2002-06-28 |
2006-10-09 |
Domantis Ltd |
Immunglobulin-enkeltvariable antigen-bindende domæner og dobbeltspecifikke konstruktioner deraf
|
|
US9321832B2
(en)
*
|
2002-06-28 |
2016-04-26 |
Domantis Limited |
Ligand
|
|
CA2505515C
(en)
|
2002-11-07 |
2013-08-27 |
Erasmus Universiteit Rotterdam |
Fret probes and methods for detecting interacting molecules
|
|
CN102584997A
(zh)
|
2002-11-08 |
2012-07-18 |
埃博灵克斯股份有限公司 |
针对肿瘤坏死因子-α的单结构域抗体及其用途
|
|
US9320792B2
(en)
|
2002-11-08 |
2016-04-26 |
Ablynx N.V. |
Pulmonary administration of immunoglobulin single variable domains and constructs thereof
|
|
EP1558647B1
(en)
|
2002-11-08 |
2015-06-10 |
Ablynx N.V. |
Single domain antibodies directed against tumour necrosis factor-alpha and uses therefor
|
|
EP3299393A1
(en)
|
2002-11-08 |
2018-03-28 |
Ablynx N.V. |
Single domain antibodies directed against tumour necrosis factor-alpha and uses therefor
|
|
GB0228210D0
(en)
|
2002-12-03 |
2003-01-08 |
Babraham Inst |
Single chain antibodies
|
|
CA2523716C
(en)
|
2003-05-31 |
2014-11-25 |
Micromet Ag |
Human anti-human cd3 binding molecules
|
|
KR20060041205A
(ko)
|
2003-07-01 |
2006-05-11 |
이뮤노메딕스, 인코오포레이티드 |
양특이성 항체들의 다가 담체들
|
|
US20050048617A1
(en)
|
2003-08-18 |
2005-03-03 |
Medimmune, Inc. |
Humanization of antibodies
|
|
AU2004280333A1
(en)
|
2003-08-22 |
2005-04-21 |
Medimmune, Llc |
Humanization of antibodies
|
|
CN100376599C
(zh)
|
2004-04-01 |
2008-03-26 |
北京安波特基因工程技术有限公司 |
基因工程重组抗cea抗cd3抗cd28线性单链三特异抗体
|
|
ES2653570T3
(es)
|
2004-05-27 |
2018-02-07 |
The Trustees Of The University Of Pennsylvania |
Células presentadoras de antígeno artificiales novedosas y usos de las mismas
|
|
KR20120133403A
(ko)
|
2004-06-01 |
2012-12-10 |
도만티스 리미티드 |
증강된 혈청 반감기를 가지는 이특이성 융합 항체
|
|
JP2008512352A
(ja)
|
2004-07-17 |
2008-04-24 |
イムクローン システムズ インコーポレイティド |
新規な四価の二重特異性抗体
|
|
US20080069772A1
(en)
|
2004-08-26 |
2008-03-20 |
Eberhard-Karls-Universitaet Tuebingen Universitaetsklinikum |
Treatment of transformed or infected biological cells
|
|
EP1634603A1
(de)
|
2004-08-26 |
2006-03-15 |
Eberhard-Karls-Universität Tübingen Universitätsklinikum |
Behandlung von transformierten oder infizierten biologischen Zellen
|
|
FR2879605B1
(fr)
|
2004-12-16 |
2008-10-17 |
Centre Nat Rech Scient Cnrse |
Production de formats d'anticorps et applications immunologiques de ces formats
|
|
AU2006204459B2
(en)
|
2005-01-05 |
2012-11-01 |
F-Star Therapeutics Limited |
Synthetic immunoglobulin domains with binding properties engineered in regions of the molecule different from the complementarity determining regions
|
|
US7833979B2
(en)
|
2005-04-22 |
2010-11-16 |
Amgen Inc. |
Toxin peptide therapeutic agents
|
|
US20060252096A1
(en)
|
2005-04-26 |
2006-11-09 |
Glycofi, Inc. |
Single chain antibody with cleavable linker
|
|
CN103254309B
(zh)
|
2005-05-18 |
2017-09-26 |
埃博灵克斯股份有限公司 |
针对肿瘤坏死因子α的改进的纳米体TM
|
|
CN101213214B
(zh)
*
|
2005-05-20 |
2014-06-25 |
埃博灵克斯股份有限公司 |
针对冯威勒布兰特因子的单一结构域vhh抗体
|
|
EP1726650A1
(en)
|
2005-05-27 |
2006-11-29 |
Universitätsklinikum Freiburg |
Monoclonal antibodies and single chain antibody fragments against cell-surface prostate specific membrane antigen
|
|
TWI323734B
(en)
|
2005-08-19 |
2010-04-21 |
Abbott Lab |
Dual variable domain immunoglobulin and uses thereof
|
|
ES2856451T3
(es)
|
2005-10-11 |
2021-09-27 |
Amgen Res Munich Gmbh |
Composiciones que comprenden anticuerpos específicos para diferentes especies, y usos de las mismas
|
|
WO2007058823A2
(en)
|
2005-11-12 |
2007-05-24 |
Eli Lilly And Company |
Anti-egfr antibodies
|
|
JP5102772B2
(ja)
|
2005-11-29 |
2012-12-19 |
ザ・ユニバーシティ・オブ・シドニー |
デミボディ：二量体化活性化治療剤
|
|
US7498142B2
(en)
|
2006-01-31 |
2009-03-03 |
Yeda Research And Development Co., Ltd. |
Methods of identifying combinations of antibodies with an improved anti-tumor activity and compositions and methods using the antibodies
|
|
WO2007115230A2
(en)
|
2006-03-30 |
2007-10-11 |
University Of Medicine And Dentistry Of New Jersey |
A strategy for homo- or hetero-dimerization of various proteins in solutions and in cells
|
|
US20070269422A1
(en)
|
2006-05-17 |
2007-11-22 |
Ablynx N.V. |
Serum albumin binding proteins with long half-lives
|
|
EP2057191A1
(en)
|
2006-08-18 |
2009-05-13 |
Ablynx N.V. |
Amino acid sequences directed against il-6r and polypeptides comprising the same for the treatment of deseases and disorders associated with il-6-mediated signalling
|
|
AU2007293614A1
(en)
*
|
2006-09-08 |
2008-03-13 |
Ablynx N.V. |
Serum albumin binding proteins with long half-lives
|
|
US20100166734A1
(en)
|
2006-12-20 |
2010-07-01 |
Edward Dolk |
Oral delivery of polypeptides
|
|
KR101589759B1
(ko)
|
2007-04-03 |
2016-01-29 |
암젠 리서치 (뮌헨) 게엠베하 |
종간 특이적 ｃｄ３―입실론 결합 도메인
|
|
CN101796072B
(zh)
|
2007-05-24 |
2014-09-24 |
埃博灵克斯股份有限公司 |
用于治疗骨疾病和病症的针对rank-l的氨基酸序列以及包括其的多肽
|
|
EP2014680A1
(en)
|
2007-07-10 |
2009-01-14 |
Friedrich-Alexander-Universität Erlangen-Nürnberg |
Recombinant, single-chain, trivalent tri-specific or bi-specific antibody derivatives
|
|
EP2170960B1
(en)
|
2007-07-13 |
2015-07-29 |
Bac Ip B.V. |
Single-domain antigen-binding proteins that bind mammalian igg
|
|
EP3492488A1
(en)
|
2007-08-22 |
2019-06-05 |
The Regents of The University of California |
Activatable binding polypeptides and methods of identification and use thereof
|
|
WO2009030285A1
(en)
|
2007-09-07 |
2009-03-12 |
Ablynx N.V. |
Binding molecules with multiple binding sites, compositions comprising the same and uses thereof
|
|
ES2667729T3
(es)
|
2007-09-26 |
2018-05-14 |
Ucb Biopharma Sprl |
Fusiones de anticuerpos con doble especificidad
|
|
DK2285408T3
(en)
|
2008-06-05 |
2019-02-04 |
Ablynx Nv |
AMINO ACID SEQUENCES AGAINST COATING PROTEINS IN A VIRUS AND POLYPEPTIDES INCLUDING THESE FOR TREATMENT OF VIRUSAL DISEASES
|
|
US20100122358A1
(en)
|
2008-06-06 |
2010-05-13 |
Crescendo Biologics Limited |
H-Chain-only antibodies
|
|
US8444976B2
(en)
|
2008-07-02 |
2013-05-21 |
Argen-X B.V. |
Antigen binding polypeptides
|
|
US20110177070A1
(en)
|
2008-07-02 |
2011-07-21 |
Emergent Product Development Seatlle, LLC |
TGF-Beta Antagonist Multi-Target Binding Proteins
|
|
AU2009299794B2
(en)
|
2008-10-01 |
2015-08-13 |
Amgen Research (Munich) Gmbh |
Cross-species-specific single domain bispecific single chain antibody
|
|
EP2352763B2
(en)
|
2008-10-01 |
2022-09-21 |
Amgen Research (Munich) GmbH |
Bispecific single chain antibodies with specificity for high molecular weight target antigens
|
|
BRPI0919841A2
(pt)
|
2008-10-01 |
2014-11-18 |
Micromet Ag |
Anticorpo de cadeia unica biespecifico de psmaxcd3, especifico de especies cruzadas
|
|
CA2740561C
(en)
|
2008-10-14 |
2021-01-19 |
National Research Council Of Canada |
Bsa-specific antibodies
|
|
EP2356131A4
(en)
|
2008-12-08 |
2012-09-12 |
Tegopharm Corp |
MASKING LIGANDS FOR REVERSIBLE INHIBITION OF VERSATILE COMPOUNDS
|
|
WO2010081173A2
(en)
|
2009-01-12 |
2010-07-15 |
Cytomx Therapeutics, Llc |
Modified antibody compositions, methods of making and using thereof
|
|
EP2210902A1
(en)
|
2009-01-14 |
2010-07-28 |
TcL Pharma |
Recombinant monovalent antibodies
|
|
PE20160653A1
(es)
|
2009-03-05 |
2016-07-24 |
Abbvie Inc |
Proteinas de union a il-17
|
|
UY32917A
(es)
|
2009-10-02 |
2011-04-29 |
Boehringer Ingelheim Int |
Moléculas de unión a dll-4
|
|
WO2011051327A2
(en)
|
2009-10-30 |
2011-05-05 |
Novartis Ag |
Small antibody-like single chain proteins
|
|
JP6184695B2
(ja)
|
2009-12-04 |
2017-08-23 |
ジェネンテック， インコーポレイテッド |
多重特異性抗体、抗体アナログ、組成物、及び方法
|
|
EP2332994A1
(en)
|
2009-12-09 |
2011-06-15 |
Friedrich-Alexander-Universität Erlangen-Nürnberg |
Trispecific therapeutics against acute myeloid leukaemia
|
|
EP2519544A1
(en)
|
2009-12-29 |
2012-11-07 |
Emergent Product Development Seattle, LLC |
Polypeptide heterodimers and uses thereof
|
|
GB2476681B
(en)
|
2010-01-04 |
2012-04-04 |
Argen X Bv |
Humanized camelid VH, VK and VL immunoglobulin domains
|
|
EP2550529B1
(en)
|
2010-03-23 |
2021-11-17 |
Iogenetics, LLC. |
Bioinformatic processes for determination of peptide binding
|
|
WO2011117423A1
(en)
|
2010-03-26 |
2011-09-29 |
Ablynx N.V. |
Immunoglobulin single variable domains directed against cxcr7
|
|
US9556273B2
(en)
|
2010-03-29 |
2017-01-31 |
Vib Vzw |
Anti-macrophage mannose receptor single variable domains for targeting and in vivo imaging of tumor-associated macrophages
|
|
WO2012009568A2
(en)
|
2010-07-16 |
2012-01-19 |
Adimab, Llc |
Antibody libraries
|
|
AU2011289275A1
(en)
|
2010-08-12 |
2013-02-21 |
Theraclone Sciences, Inc. |
Anti-hemagglutinin antibody compositions and methods of use thereof
|
|
RU2013110876A
(ru)
|
2010-08-24 |
2014-09-27 |
Рош Гликарт Аг |
Активируемые биспецифические антитела
|
|
CA2807278A1
(en)
|
2010-08-24 |
2012-03-01 |
F. Hoffmann - La Roche Ag |
Bispecific antibodies comprising a disulfide stabilized - fv fragment
|
|
WO2012042026A1
(en)
|
2010-09-30 |
2012-04-05 |
Ablynx Nv |
Biological materials related to c-met
|
|
EP2640750A1
(en)
|
2010-11-16 |
2013-09-25 |
Boehringer Ingelheim International GmbH |
Agents and methods for treating diseases that correlate with bcma expression
|
|
WO2012131053A1
(en)
*
|
2011-03-30 |
2012-10-04 |
Ablynx Nv |
Methods of treating immune disorders with single domain antibodies against tnf-alpha
|
|
CN107188969B
(zh)
|
2011-04-08 |
2021-08-27 |
美国卫生和人力服务部 |
抗-表皮生长因子受体变体iii嵌合抗原受体及其用于治疗癌症的用途
|
|
EP2710042A2
(en)
|
2011-05-16 |
2014-03-26 |
Fabion Pharmaceuticals, Inc. |
Multi-specific fab fusion proteins and methods of use
|
|
PH12013502421A1
(en)
|
2011-05-27 |
2014-01-06 |
Glaxo Group Ltd |
Bcma (cd269/tnfrsf17) -binding proteins
|
|
EP2723771B1
(en)
*
|
2011-06-23 |
2019-09-11 |
Ablynx NV |
Serum albumin binding proteins
|
|
UA117901C2
(uk)
|
2011-07-06 |
2018-10-25 |
Ґенмаб Б.В. |
Спосіб посилення ефекторної функції вихідного поліпептиду, його варіанти та їх застосування
|
|
EP2753644A1
(en)
|
2011-09-09 |
2014-07-16 |
Universiteit Utrecht Holding B.V. |
Broadly neutralizing vhh against hiv-1
|
|
AU2012311451B2
(en)
|
2011-09-23 |
2017-08-10 |
Universitat Stuttgart |
Serum half-life extension using immunoglobulin binding domains
|
|
TWI679212B
(zh)
|
2011-11-15 |
2019-12-11 |
美商安進股份有限公司 |
針對ｂｃｍａ之e3以及ｃｄ３的結合分子
|
|
US20150079093A1
(en)
|
2012-01-13 |
2015-03-19 |
Julus-Maximilians-Universität Würzburg |
Dual antigen-induced bipartite functional complementation
|
|
EP2807189B1
(en)
|
2012-01-23 |
2019-03-20 |
Ablynx N.V. |
Sequences directed against hepatocyte growth factor (hgf) and polypeptides comprising the same for the treatment of cancers and/or tumors
|
|
CA2863799C
(en)
|
2012-02-22 |
2020-09-01 |
Matthew J. FRIGAULT |
Compositions and methods for generating a persisting population of t cells useful for the treatment of cancer
|
|
ES2812849T3
(es)
|
2012-02-24 |
2021-03-18 |
Abbvie Stemcentrx Llc |
Anticuerpos anti-DLL3 y procedimientos de utilización de los mismos
|
|
GB201203442D0
(en)
|
2012-02-28 |
2012-04-11 |
Univ Birmingham |
Immunotherapeutic molecules and uses
|
|
US20150037334A1
(en)
|
2012-03-01 |
2015-02-05 |
Amgen Research (Munich) Gmbh |
Long life polypeptide binding molecules
|
|
RU2014143639A
(ru)
|
2012-03-30 |
2016-05-27 |
Байер Хелскеа Ллк |
Регулируемые протеазой антитела
|
|
CN104487587A
(zh)
|
2012-04-20 |
2015-04-01 |
新兴产品开发西雅图有限公司 |
Cd3结合多肽
|
|
US9856314B2
(en)
|
2012-06-22 |
2018-01-02 |
Cytomx Therapeutics, Inc. |
Activatable antibodies having non-binding steric moieties and methods of using the same
|
|
WO2014004549A2
(en)
|
2012-06-27 |
2014-01-03 |
Amgen Inc. |
Anti-mesothelin binding proteins
|
|
CN103566377A
(zh)
|
2012-07-18 |
2014-02-12 |
上海博笛生物科技有限公司 |
癌症的靶向免疫治疗
|
|
WO2014033304A2
(en)
|
2012-08-31 |
2014-03-06 |
arGEN-X BV |
Highly diverse combinatorial antibody libraries
|
|
KR101963231B1
(ko)
|
2012-09-11 |
2019-03-28 |
삼성전자주식회사 |
이중특이 항체의 제작을 위한 단백질 복합체 및 이를 이용한 이중특이 항체 제조 방법
|
|
JOP20200236A1
(ar)
|
2012-09-21 |
2017-06-16 |
Regeneron Pharma |
الأجسام المضادة لمضاد cd3 وجزيئات ربط الأنتيجين ثنائية التحديد التي تربط cd3 وcd20 واستخداماتها
|
|
AU2013324049B2
(en)
|
2012-09-27 |
2017-09-21 |
The United States Of America, As Represented By The Secretary, Department Of Health And Human Services |
Mesothelin antibodies and methods for eliciting potent antitumor activity
|
|
JO3519B1
(ar)
|
2013-01-25 |
2020-07-05 |
Amgen Inc |
تركيبات أجسام مضادة لأجل cdh19 و cd3
|
|
JP6420776B2
(ja)
|
2013-03-05 |
2018-11-07 |
ベイラー カレッジ オブ メディスンＢａｙｌｏｒ Ｃｏｌｌｅｇｅ Ｏｆ Ｍｅｄｉｃｉｎｅ |
免疫療法のためのエンゲージャー細胞
|
|
CA2906587C
(en)
|
2013-03-13 |
2023-02-14 |
Health Research, Inc. |
Compositions and methods for use of recombinant t cell receptors for direct recognition of tumor antigen
|
|
EP2970494B1
(en)
|
2013-03-14 |
2017-12-13 |
The Board of Regents of The University of Texas System |
Her3 specific monoclonal antibodies for diagnostic and therapeutic use
|
|
EP2968552B1
(en)
|
2013-03-14 |
2020-03-11 |
The Scripps Research Institute |
Targeting agent antibody conjugates and uses thereof
|
|
US20140302037A1
(en)
|
2013-03-15 |
2014-10-09 |
Amgen Inc. |
BISPECIFIC-Fc MOLECULES
|
|
EP2970498A4
(en)
|
2013-03-15 |
2016-11-23 |
Bayer Healthcare Llc |
PRODUCT ANTIBODIES DIRECTED AGAINST THE INHIBITOR OF THE PATHWAY OF TISSUE FACTOR
|
|
AU2014236769B2
(en)
|
2013-03-15 |
2018-09-27 |
Amgen Inc. |
Heterodimeric bispecific antibodies
|
|
US20160122436A1
(en)
|
2013-03-15 |
2016-05-05 |
Amgen Research (Munich) Gmbh |
Single chain binding molecules comprising n-terminal abp
|
|
CA2918795A1
(en)
|
2013-07-25 |
2015-01-29 |
Cytomx Therapeutics, Inc. |
Multispecific antibodies, multispecific activatable antibodies and methods of using the same
|
|
JP2016538327A
(ja)
|
2013-09-24 |
2016-12-08 |
ユニバーシティ オブ ワシントン スルー イッツ センター フォー コマーシャリゼーション |
デスモグレイン２（ｄｓｇ２）結合タンパク質およびその使用
|
|
AU2014326674B2
(en)
|
2013-09-26 |
2020-03-12 |
Ablynx Nv |
Bispecific nanobodies
|
|
ES2923641T3
(es)
|
2013-12-30 |
2022-09-29 |
Epimab Biotherapeutics Inc |
Inmunoglobulina con Fabs en tándem y usos de la misma
|
|
WO2015145360A1
(en)
|
2014-03-24 |
2015-10-01 |
Glennie Martin J |
Modified antibodies containing modified igg2 domains which elicit agonist or antagonistic properties and use thereof
|
|
US20170183410A1
(en)
|
2014-03-25 |
2017-06-29 |
Tohoku University |
HIGHLY-FUNCTIONAL IgG2 BISPECIFIC ANTIBODY
|
|
UA117289C2
(uk)
|
2014-04-02 |
2018-07-10 |
Ф. Хоффманн-Ля Рош Аг |
Мультиспецифічне антитіло
|
|
CN106661125B
(zh)
|
2014-05-02 |
2021-10-01 |
动量制药公司 |
涉及工程化Fc构建体的组合物和方法
|
|
NZ726520A
(en)
|
2014-05-29 |
2018-12-21 |
Macrogenics Inc |
Tri-specific binding molecules that specifically bind to multiple cancer antigens and methods of use thereof
|
|
GB201412659D0
(en)
|
2014-07-16 |
2014-08-27 |
Ucb Biopharma Sprl |
Molecules
|
|
AR101400A1
(es)
|
2014-07-31 |
2016-12-14 |
Amgen Res Munich Gmbh |
Constructo de anticuerpo de cadena individual biespecífico con distribución mejorada de tejido
|
|
AR101669A1
(es)
|
2014-07-31 |
2017-01-04 |
Amgen Res Munich Gmbh |
Constructos de anticuerpos para cdh19 y cd3
|
|
RS60305B1
(sr)
|
2014-09-05 |
2020-07-31 |
Janssen Pharmaceutica Nv |
Agensi koji vezuju cd123 i njihove upotrebe
|
|
CN105471609B
(zh)
|
2014-09-05 |
2019-04-05 |
华为技术有限公司 |
一种用于配置业务的方法和装置
|
|
CA2960128A1
(en)
|
2014-09-25 |
2016-03-31 |
Amgen Inc |
Protease-activatable bispecific proteins
|
|
AU2015330017A1
(en)
|
2014-10-07 |
2017-04-27 |
Cellectis |
Method for modulating car-induced immune cells activity
|
|
EP3223907A2
(en)
|
2014-11-26 |
2017-10-04 |
Xencor, Inc. |
Heterodimeric antibodies that bind cd3 and cd38
|
|
EP3029068A1
(en)
|
2014-12-03 |
2016-06-08 |
EngMab AG |
Bispecific antibodies against CD3epsilon and BCMA for use in the treatment of diseases
|
|
US11001625B2
(en)
|
2014-12-10 |
2021-05-11 |
Tufts University |
VHH based binding antibodies for anthrax and botulinum toxins and methods of making and using therefor
|
|
WO2016105450A2
(en)
|
2014-12-22 |
2016-06-30 |
Xencor, Inc. |
Trispecific antibodies
|
|
JP6772157B2
(ja)
|
2015-02-05 |
2020-10-21 |
ヤンセン ファッシンズ アンド プリベンション ベーフェーＪａｎｓｓｅｎ Ｖａｃｃｉｎｅｓ ＆ Ｐｒｅｖｅｎｔｉｏｎ Ｂ．Ｖ． |
インフルエンザヘマグルチニンに対する結合分子及びその使用
|
|
CA2976360A1
(en)
|
2015-02-11 |
2016-08-18 |
Aptevo Research And Development Llc |
Compositions and methods for combination therapy with prostate-specific membrane antigen binding proteins
|
|
CN114644689A
(zh)
|
2015-04-22 |
2022-06-21 |
农业生物群落股份有限公司 |
杀虫基因和使用方法
|
|
HK1250997A1
(zh)
|
2015-05-01 |
2019-01-18 |
基因泰克公司 |
掩蔽抗cd3抗体和使用方法
|
|
SI3294319T1
(sl)
*
|
2015-05-13 |
2024-09-30 |
Ablynx Nv |
Polipeptidi, ki rekrutirajo celice T na osnovi reaktivnosti CD3
|
|
US11400157B2
(en)
|
2015-05-13 |
2022-08-02 |
Chugai Seiyaku Kabushiki Kaisha |
Multiple antigen binding molecular fusion, pharmaceutical composition, method for identifying linear epitope, and method for preparing multiple antigen binding molecular fusion
|
|
CN111234027A
(zh)
|
2015-05-21 |
2020-06-05 |
哈普恩治疗公司 |
三特异性结合蛋白质及使用方法
|
|
WO2016187101A2
(en)
|
2015-05-21 |
2016-11-24 |
Full Spectrum Genetics, Inc. |
Method of improving characteristics of proteins
|
|
EP3960864A3
(en)
|
2015-06-03 |
2022-06-15 |
Agbiome, Inc. |
Pesticidal genes and methods of use
|
|
US10822419B2
(en)
|
2015-06-26 |
2020-11-03 |
University Of Southern California |
Masking chimeric antigen receptor T cells for tumor-specific activation
|
|
TWI829617B
(zh)
|
2015-07-31 |
2024-01-21 |
德商安美基研究（慕尼黑）公司 |
Ｆｌｔ３及ｃｄ３抗體構築體
|
|
TWI796283B
(zh)
|
2015-07-31 |
2023-03-21 |
德商安美基研究（慕尼黑）公司 |
Ｍｓｌｎ及ｃｄ３抗體構築體
|
|
WO2017027392A1
(en)
|
2015-08-07 |
2017-02-16 |
Novartis Ag |
Treatment of cancer using chimeric cd3 receptor proteins
|
|
WO2017025698A1
(en)
|
2015-08-11 |
2017-02-16 |
Queen Mary University Of London |
Bispecific, cleavable antibodies
|
|
CN105384825B
(zh)
|
2015-08-11 |
2018-06-01 |
南京传奇生物科技有限公司 |
一种基于单域抗体的双特异性嵌合抗原受体及其应用
|
|
PT3337824T
(pt)
|
2015-08-17 |
2020-09-10 |
Janssen Pharmaceutica Nv |
Anticorpos anti-bcma, moléculas de ligação a antigénio biespecíficas que ligam bcma e cd3, e suas utilizações
|
|
CN106519037B
(zh)
|
2015-09-11 |
2019-07-23 |
科济生物医药（上海）有限公司 |
可活化的嵌合受体
|
|
CA3004299A1
(en)
|
2015-11-05 |
2017-05-11 |
City Of Hope |
Methods for preparing cells for adoptive t cell therapy
|
|
AU2016358296B2
(en)
|
2015-11-19 |
2020-05-21 |
Revitope Limited |
Functional antibody fragment complementation for a two-components system for redirected killing of unwanted cells
|
|
PT3411402T
(pt)
|
2016-02-03 |
2022-02-01 |
Amgen Inc |
Construtos de anticorpos biespecíficos engajadores de células t contra bcma e cd3
|
|
CN105968204B
(zh)
|
2016-02-03 |
2020-01-21 |
中国人民解放军第三军医大学第一附属医院 |
一种抗前列腺特异性膜抗原的单域重链抗体
|
|
CN105968201A
(zh)
|
2016-02-03 |
2016-09-28 |
南昌大学 |
针对前列腺特异性膜抗原的单域重链抗体
|
|
CN108884126B
(zh)
|
2016-02-03 |
2022-03-18 |
广州康睿生物医药科技股份有限公司 |
用于治疗眼睛病症或疾病的化合物
|
|
TW201808990A
(zh)
|
2016-03-08 |
2018-03-16 |
馬弗瑞克療法公司 |
可誘導性結合蛋白和使用方法
|
|
JP7034489B2
(ja)
|
2016-03-15 |
2022-03-14 |
アイタブメッド （エイチケイ） リミテッド |
多重特異性Ｆａｂ融合タンパクおよびその使用
|
|
WO2017161206A1
(en)
|
2016-03-16 |
2017-09-21 |
Halozyme, Inc. |
Conjugates containing conditionally active antibodies or antigen-binding fragments thereof, and methods of use
|
|
BR112018073739A2
(pt)
|
2016-05-20 |
2019-02-26 |
Harpoon Therapeutics, Inc. |
proteína de ligação de albumina sérica de domínio único
|
|
CN109641046B
(zh)
|
2016-05-20 |
2023-11-07 |
哈普恩治疗公司 |
单链可变片段cd3结合蛋白质
|
|
WO2018017863A1
(en)
|
2016-07-21 |
2018-01-25 |
Dcb-Usa Llc |
Modified antigen-binding fab fragments and antigen-binding molecules comprising the same
|
|
WO2018026953A1
(en)
|
2016-08-02 |
2018-02-08 |
TCR2 Therapeutics Inc. |
Compositions and methods for tcr reprogramming using fusion proteins
|
|
IL302917A
(en)
|
2016-10-07 |
2023-07-01 |
Tcr2 Therapeutics Inc |
Compositions and methods for t-cell receptors reprogramming using fusion proteins
|
|
US20190225702A1
(en)
|
2016-10-14 |
2019-07-25 |
Harpoon Therapeutics, Inc. |
Innate immune cell trispecific binding proteins and methods of use
|
|
US11124577B2
(en)
|
2016-11-02 |
2021-09-21 |
Engmab Sàrl |
Bispecific antibody against BCMA and CD3 and an immunological drug for combined use in treating multiple myeloma
|
|
JP6812551B2
(ja)
|
2016-11-23 |
2021-01-13 |
ハープーン セラピューティクス，インク． |
前立腺特異的膜抗原結合タンパク質
|
|
JP7215997B2
(ja)
|
2016-11-23 |
2023-01-31 |
ハープーン セラピューティクス，インク． |
前立腺特異的膜抗原（ｐｓｍａ）を標的とする三重特異性タンパク質と使用方法
|
|
WO2018136725A1
(en)
|
2017-01-19 |
2018-07-26 |
Harpoon Therapeutics, Inc. |
Innate immune cell inducible binding proteins and methods of use
|
|
AU2018209012B2
(en)
|
2017-01-23 |
2024-10-03 |
Crage Medical Co., Limited |
BCMA-targeting antibody and use thereof
|
|
WO2018160671A1
(en)
|
2017-02-28 |
2018-09-07 |
Harpoon Therapeutics, Inc. |
Targeted checkpoint inhibitors and methods of use
|
|
US11535668B2
(en)
|
2017-02-28 |
2022-12-27 |
Harpoon Therapeutics, Inc. |
Inducible monovalent antigen binding protein
|
|
AU2018231127A1
(en)
|
2017-03-09 |
2019-09-19 |
Cytomx Therapeutics, Inc. |
CD147 antibodies, activatable CD147 antibodies, and methods of making and use thereof
|
|
US20200115461A1
(en)
|
2017-05-03 |
2020-04-16 |
Harpoon Therapeutics, Inc. |
Compositions and methods for adoptive cell therapies
|
|
CA3063359A1
(en)
|
2017-05-12 |
2018-11-15 |
Harpoon Therapeutics, Inc. |
Mesothelin binding proteins
|
|
CA3063362A1
(en)
|
2017-05-12 |
2018-11-15 |
Harpoon Therapeutics, Inc. |
Msln targeting trispecific proteins and methods of use
|
|
EP3630841A1
(en)
|
2017-06-02 |
2020-04-08 |
Pfizer Inc. |
Antibodies specific for flt3 and their uses
|
|
WO2018232020A1
(en)
|
2017-06-13 |
2018-12-20 |
TCR2 Therapeutics Inc. |
Compositions and methods for tcr reprogramming using fusion proteins
|
|
WO2019025983A1
(en)
|
2017-08-01 |
2019-02-07 |
Medimmune, Llc |
CONJUGATED MONOCLONAL ANTIBODY-MEDICINE DIRECTED AGAINST BCMA
|
|
JP7151175B2
(ja)
|
2017-09-15 |
2022-10-12 |
日本電産株式会社 |
変速機及びアクチュエータ
|
|
IL315737A
(en)
|
2017-10-13 |
2024-11-01 |
Harpoon Therapeutics Inc |
B-cell maturation antigen-binding proteins
|
|
UA129446C2
(uk)
|
2017-10-13 |
2025-04-30 |
Гарпун Терап'Ютікс, Інк. |
Триспецифічні білки і способи їх застосування
|
|
WO2019222283A1
(en)
|
2018-05-14 |
2019-11-21 |
Harpoon Therapeutics, Inc. |
Binding moiety for conditional activation of immunoglobulin molecules
|
|
US20210284728A1
(en)
|
2018-05-14 |
2021-09-16 |
Harpoon Therapeutics, Inc. |
Dual binding moiety
|
|
WO2019222282A1
(en)
|
2018-05-14 |
2019-11-21 |
Harpoon Therapeutics, Inc. |
Conditionally activated binding protein comprising a sterically occluded target binding domain
|
|
TWI848951B
(zh)
|
2018-06-01 |
2024-07-21 |
瑞士商諾華公司 |
針對ｂｃｍａ之結合分子及其用途
|
|
US20220054544A1
(en)
|
2018-09-21 |
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|
|
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|
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|
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|
|
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(zh)
|
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|
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|
|
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|
|
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