JP2019500414A5 - - Google Patents

Download PDF

Info

Publication number
JP2019500414A5
JP2019500414A5 JP2018546742A JP2018546742A JP2019500414A5 JP 2019500414 A5 JP2019500414 A5 JP 2019500414A5 JP 2018546742 A JP2018546742 A JP 2018546742A JP 2018546742 A JP2018546742 A JP 2018546742A JP 2019500414 A5 JP2019500414 A5 JP 2019500414A5
Authority
JP
Japan
Prior art keywords
polypeptide
amino acid
seq
acid substitutions
fgf2
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2018546742A
Other languages
English (en)
Japanese (ja)
Other versions
JP7131772B2 (ja
JP2019500414A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/EP2016/073567 external-priority patent/WO2017089016A1/en
Publication of JP2019500414A publication Critical patent/JP2019500414A/ja
Publication of JP2019500414A5 publication Critical patent/JP2019500414A5/ja
Application granted granted Critical
Publication of JP7131772B2 publication Critical patent/JP7131772B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

JP2018546742A 2015-11-27 2016-10-03 熱安定性ｆｇｆ２ポリペプチド及びその使用 Active JP7131772B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP15196802.1 2015-11-27
EP15196802 2015-11-27
PCT/EP2016/073567 WO2017089016A1 (en) 2015-11-27 2016-10-03 Thermostable fgf2 polypeptide, use thereof

Publications (3)

Publication Number Publication Date
JP2019500414A JP2019500414A (ja) 2019-01-10
JP2019500414A5 true JP2019500414A5 (enExample) 2019-12-05
JP7131772B2 JP7131772B2 (ja) 2022-09-06

Family

ID=54754475

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2018546742A Active JP7131772B2 (ja) 2015-11-27 2016-10-03 熱安定性ｆｇｆ２ポリペプチド及びその使用

Country Status (12)

Country Link
US (1) US11746135B2 (enExample)
EP (1) EP3380508B1 (enExample)
JP (1) JP7131772B2 (enExample)
KR (1) KR102650035B1 (enExample)
CN (1) CN108779158B (enExample)
AU (1) AU2016359722B2 (enExample)
CA (1) CA3006388C (enExample)
ES (1) ES2824479T3 (enExample)
LT (1) LT3380508T (enExample)
PL (1) PL3380508T3 (enExample)
SG (1) SG11201804402WA (enExample)
WO (1) WO2017089016A1 (enExample)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112190531B (zh) * 2019-06-19 2022-11-01 湖北医药学院 抗细胞衰老制剂及其制备方法和应用、细胞及其构建方法
JP2022548776A (ja) * 2019-09-19 2022-11-21 ノースウェスタン ユニバーシティ ヒト人工多能性幹細胞のための費用効果の高い培地およびプロトコル
JP7441948B2 (ja) * 2019-11-25 2024-03-01 コリア インスティテュート オブ オーシャン サイエンス テクノロジー 温度安定性およびタンパク質分解酵素抵抗性を向上させたｆｇｆ２ポリペプチド並びにその用途
KR102428940B1 (ko) * 2019-11-25 2022-08-03 한국해양과학기술원 온도안정성 및 단백질 분해효소 저항성을 향상시킨 fgf2 폴리펩타이드 및 그 용도
CZ309550B6 (cs) * 2021-06-15 2023-04-05 Enantis s.r.o Termostabilní polypeptid na bázi FGF18 a jeho použití
GB2616475A (en) * 2022-03-11 2023-09-13 Multus Biotechnology Ltd Engineered fibroblast growth factor variants
AU2023384043A1 (en) * 2022-11-25 2025-06-19 Btl Healthcare Technologies A.S. The fgf-2 polypeptides with improved stability, the process for preparing the fgf-2 polypeptides and use thereof
CN116041478A (zh) * 2022-12-19 2023-05-02 太东(镇江)生物科技有限公司 基于大肠杆菌体外纯化系统的人重组热稳定蛋白fgf2制备方法
KR20240173283A (ko) * 2023-06-02 2024-12-11 (주)피앤피바이오팜 고안정성 활성지속형 염기성 섬유아세포 성장인자 변이체를 이용한 줄기세포의 배양방법
KR20240173282A (ko) * 2023-06-02 2024-12-11 (주)피앤피바이오팜 고안정성 활성지속형 염기성 섬유아세포 성장인자 변이체를 이용한 줄기세포 유래 엑소좀의 제조방법
WO2025141173A1 (en) 2023-12-28 2025-07-03 Meatable B.V. Methods of increasing differentiation and/or fat accumulation in cells
WO2025186217A1 (en) 2024-03-05 2025-09-12 The Cultivated B. Gmbh Animal collagen from non-animal sources
EP4613865A1 (en) 2024-03-05 2025-09-10 The Cultivated B. GmbH Animal collagen from non-animal sources
WO2026093988A1 (en) * 2024-11-01 2026-05-07 Btl Healthcare Technologies A.S. The fgf-2 polypeptides with improved thermal and oxidative stability, the process for preparing the fgf-2 polypeptides and use thereof

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU614137B2 (en) 1988-06-06 1991-08-22 Takeda Chemical Industries Ltd. Stabilized fgf composition and production thereof
US5202311A (en) 1988-08-19 1993-04-13 Children's Medical Center Corporation Stabilized fgf composition
CA2020654A1 (en) 1989-07-07 1991-01-08 Yohko Akiyama Stabilized fgf composition and production thereof
US5143829A (en) 1990-03-29 1992-09-01 California Biotechnology Inc. High level expression of basic fibroblast growth factor having a homogeneous n-terminus
EP0730651B1 (en) * 1993-09-24 2005-07-06 Wyeth Holdings Corporation Surface loop structural analogues of fibroblast growth factors
EP1011655A1 (en) * 1997-02-26 2000-06-28 Ciblex Corporation Inhibitors of leaderless protein export
AU2001286996A1 (en) 2000-08-31 2002-03-13 Chiron Corporation Stabilized fgf formulations containing reducing agents
AT410798B (de) 2001-01-26 2003-07-25 Cistem Biotechnologies Gmbh Verfahren zur identifizierung, isolierung und herstellung von antigenen gegen ein spezifisches pathogen
EP1444995A1 (en) 2003-02-06 2004-08-11 Institut National De La Sante Et De La Recherche Medicale (Inserm) FGF-2 derived proteins for the preparation of biomaterials or medical devices such as stents
US7816140B2 (en) * 2005-06-14 2010-10-19 The United States Of America As Represented By The Department Of Veterans Affairs Composition and methods for osteogenic gene therapy
US20070212332A1 (en) * 2005-08-11 2007-09-13 Department Of Veterans Affairs Methods for accelerating bone repair
WO2008038287A2 (en) * 2006-09-28 2008-04-03 Hepacore Ltd. N-terminal fgf variants having increased receptor selectivity and uses thereof
US7659379B1 (en) 2007-05-24 2010-02-09 Florida State University Research Foundation, Inc. Mutants of human fibroblast growth factor having increased stability and/or mitogenic potency
US8461111B2 (en) 2009-05-20 2013-06-11 Florida State University Research Foundation Fibroblast growth factor mutants having improved functional half-life and methods of their use
EP2333074A1 (en) * 2009-12-14 2011-06-15 Robert Steinfeld Substances and methods for the treatment of lysosmal storage diseases
US8481308B2 (en) 2010-07-01 2013-07-09 Regenerative Research Foundation Methods for culturing undifferentiated cells using sustained release compositions
US9169309B2 (en) 2011-03-01 2015-10-27 Humanzyme Inc. Thermostable variants of fibroblast growth factors
US9925270B2 (en) 2011-11-28 2018-03-27 The Regents Of The University Of California bFGF-polymer conjugates, methods for making the same and applications thereof
US9023644B2 (en) 2011-12-16 2015-05-05 Wisconsin Alumni Research Foundation FGF having enhanced stability
US8772460B2 (en) 2011-12-16 2014-07-08 Wisconsin Alumni Research Foundation Thermostable FGF-2 mutant having enhanced stability
US9474785B2 (en) * 2012-06-07 2016-10-25 New York University Chimeric fibroblast growth factor 19 proteins and methods of use
EP2930181B1 (en) 2014-04-07 2017-10-11 Miltenyi Biotec GmbH Fibroblast growth factor muteins with increased activity

Similar Documents

Publication Publication Date Title
EP4467650A3 (en) Scaffold proteins
AR125394A2 (es) Métodos y composiciones para la expresión génica en plantas
MX2022005328A (es) Composiciones y metodos para el reemplazo de alelos con adn codificado por arn.
EA201991440A1 (ru) ТЕРМОСТАБИЛЬНЫЕ НУКЛЕАЗЫ Cas9
AR108442A1 (es) Proteínas de fusión gdf15 y usos de estas
JP2018510622A5 (enExample)
RU2017134456A (ru) Рекомбинантные связывающие белки и их применение
HRP20231496T1 (hr) Cistein proteaza
JP2021505201A5 (enExample)
JP2016519138A5 (enExample)
JP2017524380A5 (ja) 腫瘍血管遮断剤であるポリペプチド、遺伝子、発現ベクター、腫瘍血管遮断剤の組成物、及び腫瘍血管遮断剤であるポリペプチドの調製方法
JP2018506286A5 (enExample)
NZ602351A (en) Axmi-115, axmi-113, axmi-005, axmi-163 and axmi-184 : vip3a insecticidal proteins from bacillus thuringiensis and methods for their use
AR050088A1 (es) Plantas de girasol con resistencia herbicida, polinucleotidos codificantes de las subunidades largas de la proteina acido acetohidroxi-sintasa con resistencia herbicida y metodos de uso
JP2015212284A5 (enExample)
CN109937252A (zh) 重组dna聚合酶
JP2017514522A5 (enExample)
EA201791238A1 (ru) Способы и композиции, в которых используются варианты полипептидов klotho
JP2018531624A5 (enExample)
JP2014510519A5 (enExample)
DE602005020165D1 (de) Verfahren zur herstellung von l-arginin, l-ornithin oder l-citrullin
Narciandi et al. A novel subclass of bovine ß-defensins links reproduction and immunology
MX2021004714A (es) Proteina cas9 modificada, y uso de la misma.
NZ724196A (en) Uti fusion proteins
MX2021001507A (es) Farmaco de diagnostico y metodo de diagnostico para la enfermedad de alzheimer.