PL3380508T3 - Termostabilny polipeptyd fgf2, jego zastosowanie - Google Patents
Termostabilny polipeptyd fgf2, jego zastosowanieInfo
- Publication number
- PL3380508T3 PL3380508T3 PL16781318T PL16781318T PL3380508T3 PL 3380508 T3 PL3380508 T3 PL 3380508T3 PL 16781318 T PL16781318 T PL 16781318T PL 16781318 T PL16781318 T PL 16781318T PL 3380508 T3 PL3380508 T3 PL 3380508T3
- Authority
- PL
- Poland
- Prior art keywords
- fgf2 polypeptide
- thermostable
- thermostable fgf2
- polypeptide
- fgf2
- Prior art date
Links
- 101150019331 FGF2 gene Proteins 0.000 title 1
- YSFTYXKQUONNFY-NQXPEFQPSA-N fgf2 Chemical compound C([C@@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(O)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(O)=O)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)CNC(=O)[C@H]1N(CCC1)C(=O)[C@H]1N(CCC1)C(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@H](C)NC(=O)CNC(=O)[C@H](CO)NC(=O)CNC(=O)CNC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H]1NCCC1)C1=CC=CC=C1 YSFTYXKQUONNFY-NQXPEFQPSA-N 0.000 title 1
- 229920001184 polypeptide Polymers 0.000 title 1
- 102000004196 processed proteins & peptides Human genes 0.000 title 1
- 108090000765 processed proteins & peptides Proteins 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/50—Fibroblast growth factor [FGF]
- C07K14/503—Fibroblast growth factor [FGF] basic FGF [bFGF]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/0018—Culture media for cell or tissue culture
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0603—Embryonic cells ; Embryoid bodies
- C12N5/0606—Pluripotent embryonic cells, e.g. embryonic stem cells [ES]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0696—Artificially induced pluripotent stem cells, e.g. iPS
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/20—Fusion polypeptide containing a tag with affinity for a non-protein ligand
- C07K2319/21—Fusion polypeptide containing a tag with affinity for a non-protein ligand containing a His-tag
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/50—Fusion polypeptide containing protease site
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/115—Basic fibroblast growth factor (bFGF, FGF-2)
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Biotechnology (AREA)
- Wood Science & Technology (AREA)
- Biochemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Cell Biology (AREA)
- Developmental Biology & Embryology (AREA)
- Toxicology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Reproductive Health (AREA)
- Gynecology & Obstetrics (AREA)
- Dermatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Epidemiology (AREA)
- Transplantation (AREA)
- Birds (AREA)
- Rheumatology (AREA)
- Heart & Thoracic Surgery (AREA)
- Neurosurgery (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP15196802 | 2015-11-27 | ||
| PCT/EP2016/073567 WO2017089016A1 (en) | 2015-11-27 | 2016-10-03 | Thermostable fgf2 polypeptide, use thereof |
| EP16781318.7A EP3380508B1 (en) | 2015-11-27 | 2016-10-03 | Thermostable fgf2 polypeptide, use thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL3380508T3 true PL3380508T3 (pl) | 2021-07-12 |
Family
ID=54754475
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL16781318T PL3380508T3 (pl) | 2015-11-27 | 2016-10-03 | Termostabilny polipeptyd fgf2, jego zastosowanie |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US11746135B2 (pl) |
| EP (1) | EP3380508B1 (pl) |
| JP (1) | JP7131772B2 (pl) |
| KR (1) | KR102650035B1 (pl) |
| CN (1) | CN108779158A (pl) |
| AU (1) | AU2016359722B2 (pl) |
| BR (1) | BR112018010676A2 (pl) |
| CA (1) | CA3006388C (pl) |
| ES (1) | ES2824479T3 (pl) |
| LT (1) | LT3380508T (pl) |
| PL (1) | PL3380508T3 (pl) |
| SG (1) | SG11201804402WA (pl) |
| WO (1) | WO2017089016A1 (pl) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112190531B (zh) * | 2019-06-19 | 2022-11-01 | 湖北医药学院 | 抗细胞衰老制剂及其制备方法和应用、细胞及其构建方法 |
| US20210087525A1 (en) * | 2019-09-19 | 2021-03-25 | Northwestern University | Cost effective culture media and protocol for human induced pluripotent stem cells |
| KR102428940B1 (ko) * | 2019-11-25 | 2022-08-03 | 한국해양과학기술원 | 온도안정성 및 단백질 분해효소 저항성을 향상시킨 fgf2 폴리펩타이드 및 그 용도 |
| WO2021107473A1 (ko) * | 2019-11-25 | 2021-06-03 | 한국해양과학기술원 | 온도안정성 및 단백질 분해효소 저항성을 향상시킨 fgf2 폴리펩타이드 및 그 용도 |
| CZ309550B6 (cs) * | 2021-06-15 | 2023-04-05 | Enantis s.r.o | Termostabilní polypeptid na bázi FGF18 a jeho použití |
| GB2616475A (en) * | 2022-03-11 | 2023-09-13 | Multus Biotechnology Ltd | Engineered fibroblast growth factor variants |
| AU2023384043A1 (en) * | 2022-11-25 | 2025-06-19 | Btl Healthcare Technologies A.S. | The fgf-2 polypeptides with improved stability, the process for preparing the fgf-2 polypeptides and use thereof |
| CN116041478A (zh) * | 2022-12-19 | 2023-05-02 | 太东(镇江)生物科技有限公司 | 基于大肠杆菌体外纯化系统的人重组热稳定蛋白fgf2制备方法 |
| KR20240173282A (ko) * | 2023-06-02 | 2024-12-11 | (주)피앤피바이오팜 | 고안정성 활성지속형 염기성 섬유아세포 성장인자 변이체를 이용한 줄기세포 유래 엑소좀의 제조방법 |
| KR20240173283A (ko) * | 2023-06-02 | 2024-12-11 | (주)피앤피바이오팜 | 고안정성 활성지속형 염기성 섬유아세포 성장인자 변이체를 이용한 줄기세포의 배양방법 |
| WO2025141173A1 (en) | 2023-12-28 | 2025-07-03 | Meatable B.V. | Methods of increasing differentiation and/or fat accumulation in cells |
| EP4613865A1 (en) | 2024-03-05 | 2025-09-10 | The Cultivated B. GmbH | Animal collagen from non-animal sources |
| WO2025186217A1 (en) | 2024-03-05 | 2025-09-12 | The Cultivated B. Gmbh | Animal collagen from non-animal sources |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU614137B2 (en) | 1988-06-06 | 1991-08-22 | Takeda Chemical Industries Ltd. | Stabilized fgf composition and production thereof |
| US5202311A (en) | 1988-08-19 | 1993-04-13 | Children's Medical Center Corporation | Stabilized fgf composition |
| CA2020654A1 (en) | 1989-07-07 | 1991-01-08 | Yohko Akiyama | Stabilized fgf composition and production thereof |
| US5143829A (en) | 1990-03-29 | 1992-09-01 | California Biotechnology Inc. | High level expression of basic fibroblast growth factor having a homogeneous n-terminus |
| WO1995008630A1 (en) * | 1993-09-24 | 1995-03-30 | American Cyanamid Company | Surface loop structural analogues of fibroblast growth factors |
| US6083706A (en) * | 1997-02-26 | 2000-07-04 | Ciblex Corporation | Inhibitors of leaderless protein export |
| WO2002017956A2 (en) | 2000-08-31 | 2002-03-07 | Chiron Corporation | Stabilized fgf formulations containing reducing agents |
| AT410798B (de) | 2001-01-26 | 2003-07-25 | Cistem Biotechnologies Gmbh | Verfahren zur identifizierung, isolierung und herstellung von antigenen gegen ein spezifisches pathogen |
| EP1444995A1 (en) | 2003-02-06 | 2004-08-11 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | FGF-2 derived proteins for the preparation of biomaterials or medical devices such as stents |
| US7816140B2 (en) * | 2005-06-14 | 2010-10-19 | The United States Of America As Represented By The Department Of Veterans Affairs | Composition and methods for osteogenic gene therapy |
| US20070212332A1 (en) * | 2005-08-11 | 2007-09-13 | Department Of Veterans Affairs | Methods for accelerating bone repair |
| WO2008038287A2 (en) | 2006-09-28 | 2008-04-03 | Hepacore Ltd. | N-terminal fgf variants having increased receptor selectivity and uses thereof |
| US7659379B1 (en) | 2007-05-24 | 2010-02-09 | Florida State University Research Foundation, Inc. | Mutants of human fibroblast growth factor having increased stability and/or mitogenic potency |
| US8461111B2 (en) | 2009-05-20 | 2013-06-11 | Florida State University Research Foundation | Fibroblast growth factor mutants having improved functional half-life and methods of their use |
| EP2333074A1 (en) | 2009-12-14 | 2011-06-15 | Robert Steinfeld | Substances and methods for the treatment of lysosmal storage diseases |
| EP4202040A1 (en) | 2010-07-01 | 2023-06-28 | Regenerative Research Foundation | Methods for culturing undifferentiated cells using sustained release compositions |
| US9169309B2 (en) * | 2011-03-01 | 2015-10-27 | Humanzyme Inc. | Thermostable variants of fibroblast growth factors |
| WO2013082196A1 (en) | 2011-11-28 | 2013-06-06 | The Regents Of The University Of California | bFGF-POLYMER CONJUGATES, METHODS FOR MAKING THE SAME AND APPLICATIONS THEREOF |
| US8772460B2 (en) | 2011-12-16 | 2014-07-08 | Wisconsin Alumni Research Foundation | Thermostable FGF-2 mutant having enhanced stability |
| WO2013090911A1 (en) | 2011-12-16 | 2013-06-20 | Wisconsin Alumni Research Foundation | Method for supporting human pluri potent stem cell cultures comprising culturing the cells in a medium comprising thermostable fgf - 1 proteins |
| US9474785B2 (en) * | 2012-06-07 | 2016-10-25 | New York University | Chimeric fibroblast growth factor 19 proteins and methods of use |
| EP2930181B1 (en) * | 2014-04-07 | 2017-10-11 | Miltenyi Biotec GmbH | Fibroblast growth factor muteins with increased activity |
-
2016
- 2016-10-03 EP EP16781318.7A patent/EP3380508B1/en active Active
- 2016-10-03 CN CN201680076784.3A patent/CN108779158A/zh active Pending
- 2016-10-03 KR KR1020187018035A patent/KR102650035B1/ko active Active
- 2016-10-03 SG SG11201804402WA patent/SG11201804402WA/en unknown
- 2016-10-03 WO PCT/EP2016/073567 patent/WO2017089016A1/en not_active Ceased
- 2016-10-03 US US15/778,743 patent/US11746135B2/en active Active
- 2016-10-03 BR BR112018010676-3A patent/BR112018010676A2/pt active IP Right Grant
- 2016-10-03 AU AU2016359722A patent/AU2016359722B2/en active Active
- 2016-10-03 LT LTEP16781318.7T patent/LT3380508T/lt unknown
- 2016-10-03 JP JP2018546742A patent/JP7131772B2/ja active Active
- 2016-10-03 ES ES16781318T patent/ES2824479T3/es active Active
- 2016-10-03 PL PL16781318T patent/PL3380508T3/pl unknown
- 2016-10-03 CA CA3006388A patent/CA3006388C/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| CN108779158A (zh) | 2018-11-09 |
| EP3380508B1 (en) | 2020-07-22 |
| US11746135B2 (en) | 2023-09-05 |
| US20200270320A1 (en) | 2020-08-27 |
| ES2824479T3 (es) | 2021-05-12 |
| JP2019500414A (ja) | 2019-01-10 |
| SG11201804402WA (en) | 2018-06-28 |
| JP7131772B2 (ja) | 2022-09-06 |
| LT3380508T (lt) | 2020-11-10 |
| EP3380508A1 (en) | 2018-10-03 |
| AU2016359722B2 (en) | 2020-09-17 |
| KR102650035B1 (ko) | 2024-03-20 |
| BR112018010676A2 (pt) | 2019-04-09 |
| WO2017089016A1 (en) | 2017-06-01 |
| CA3006388C (en) | 2023-05-09 |
| KR20180080335A (ko) | 2018-07-11 |
| CA3006388A1 (en) | 2017-06-01 |
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