JP2016519138A5 - - Google Patents
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- Publication number
- JP2016519138A5 JP2016519138A5 JP2016512345A JP2016512345A JP2016519138A5 JP 2016519138 A5 JP2016519138 A5 JP 2016519138A5 JP 2016512345 A JP2016512345 A JP 2016512345A JP 2016512345 A JP2016512345 A JP 2016512345A JP 2016519138 A5 JP2016519138 A5 JP 2016519138A5
- Authority
- JP
- Japan
- Prior art keywords
- pain
- protein
- tafa4
- seq
- use according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 101000788132 Homo sapiens Chemokine-like protein TAFA-4 Proteins 0.000 claims description 27
- 102100025944 Chemokine-like protein TAFA-4 Human genes 0.000 claims description 25
- 108090000623 proteins and genes Proteins 0.000 claims description 12
- 102000004169 proteins and genes Human genes 0.000 claims description 12
- 125000003275 alpha amino acid group Chemical group 0.000 claims description 7
- 210000000929 nociceptor Anatomy 0.000 claims description 7
- 108091008700 nociceptors Proteins 0.000 claims description 7
- 150000001875 compounds Chemical class 0.000 claims description 5
- 241001465754 Metazoa Species 0.000 claims description 2
- 208000002193 Pain Diseases 0.000 claims 10
- 230000036407 pain Effects 0.000 claims 8
- 208000004454 Hyperalgesia Diseases 0.000 claims 2
- 241000283984 Rodentia Species 0.000 claims 2
- 101150099849 Tafa4 gene Proteins 0.000 claims 2
- 208000004296 neuralgia Diseases 0.000 claims 2
- 208000021722 neuropathic pain Diseases 0.000 claims 2
- 208000000094 Chronic Pain Diseases 0.000 claims 1
- 208000035154 Hyperesthesia Diseases 0.000 claims 1
- 206010065390 Inflammatory pain Diseases 0.000 claims 1
- 241000124008 Mammalia Species 0.000 claims 1
- 208000028389 Nerve injury Diseases 0.000 claims 1
- 208000001294 Nociceptive Pain Diseases 0.000 claims 1
- 239000004480 active ingredient Substances 0.000 claims 1
- 208000005298 acute pain Diseases 0.000 claims 1
- 206010053552 allodynia Diseases 0.000 claims 1
- 230000036592 analgesia Effects 0.000 claims 1
- 230000003070 anti-hyperalgesia Effects 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 230000002779 inactivation Effects 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 230000001404 mediated effect Effects 0.000 claims 1
- 230000008764 nerve damage Effects 0.000 claims 1
- 230000009261 transgenic effect Effects 0.000 claims 1
- 208000009935 visceral pain Diseases 0.000 claims 1
- 239000000556 agonist Substances 0.000 description 10
- 125000000539 amino acid group Chemical group 0.000 description 10
- 150000001413 amino acids Chemical class 0.000 description 7
- 239000012634 fragment Substances 0.000 description 6
- 210000001153 interneuron Anatomy 0.000 description 4
- 108020003175 receptors Proteins 0.000 description 4
- 102000039446 nucleic acids Human genes 0.000 description 3
- 108020004707 nucleic acids Proteins 0.000 description 3
- 150000007523 nucleic acids Chemical group 0.000 description 3
- 108090000765 processed proteins & peptides Proteins 0.000 description 3
- 210000003925 spinal cord interneuron Anatomy 0.000 description 3
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 description 2
- 101100424415 Mus musculus Tafa4 gene Proteins 0.000 description 2
- 108010033276 Peptide Fragments Proteins 0.000 description 2
- 102000007079 Peptide Fragments Human genes 0.000 description 2
- 210000004899 c-terminal region Anatomy 0.000 description 2
- 210000003169 central nervous system Anatomy 0.000 description 2
- 102000054241 human TAFA4 Human genes 0.000 description 2
- 230000001537 neural effect Effects 0.000 description 2
- 230000035945 sensitivity Effects 0.000 description 2
- 210000000278 spinal cord Anatomy 0.000 description 2
- 210000001170 unmyelinated nerve fiber Anatomy 0.000 description 2
- 108090000312 Calcium Channels Proteins 0.000 description 1
- 102000003922 Calcium Channels Human genes 0.000 description 1
- 108091005461 Nucleic proteins Chemical group 0.000 description 1
- 102000004257 Potassium Channel Human genes 0.000 description 1
- 108010076504 Protein Sorting Signals Proteins 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 230000005284 excitation Effects 0.000 description 1
- 108020004999 messenger RNA Proteins 0.000 description 1
- 239000002773 nucleotide Substances 0.000 description 1
- 125000003729 nucleotide group Chemical group 0.000 description 1
- 108020001213 potassium channel Proteins 0.000 description 1
- 239000002243 precursor Substances 0.000 description 1
- 238000011002 quantification Methods 0.000 description 1
- 238000003753 real-time PCR Methods 0.000 description 1
- 102000005962 receptors Human genes 0.000 description 1
- 210000001103 thalamus Anatomy 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP13305592.1 | 2013-05-06 | ||
| EP13305592.1A EP2801369A1 (en) | 2013-05-06 | 2013-05-06 | TAFA4 compounds and uses thereof for treating pain |
| PCT/EP2014/059247 WO2014180853A1 (en) | 2013-05-06 | 2014-05-06 | Tafa4 compounds and uses thereof for treating pain |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016519138A JP2016519138A (ja) | 2016-06-30 |
| JP2016519138A5 true JP2016519138A5 (enExample) | 2018-08-30 |
| JP6487419B2 JP6487419B2 (ja) | 2019-03-20 |
Family
ID=48428409
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016512345A Active JP6487419B2 (ja) | 2013-05-06 | 2014-05-06 | Ｔａｆａ４化合物及び疼痛を処置するためのその使用 |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US9884088B2 (enExample) |
| EP (2) | EP2801369A1 (enExample) |
| JP (1) | JP6487419B2 (enExample) |
| CN (1) | CN105209056B (enExample) |
| CA (2) | CA2910652C (enExample) |
| DK (1) | DK2994157T3 (enExample) |
| ES (1) | ES2813629T3 (enExample) |
| WO (1) | WO2014180853A1 (enExample) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2016147825A1 (ja) * | 2015-03-13 | 2016-09-22 | シスメックス株式会社 | 被検物質の検出方法およびその方法に用いられる試薬キット |
| WO2019089465A1 (en) * | 2017-10-30 | 2019-05-09 | The Regents Of The University Of California | Calibration free in-vivo measurement of analytes using electrochemical sensors |
| JP7171081B2 (ja) * | 2018-04-24 | 2022-11-15 | ニューラクル サイエンス カンパニー リミテッド | 神経病性疼痛の治療のための配列類似性１９、メンバーａ５抗体を有する抗ファミリーの用途 |
| ES2943136T3 (es) * | 2018-09-27 | 2023-06-09 | Inst Nat Sante Rech Med | Polipéptido de TAFA4 para su uso para reducir la inflamación cutánea |
| CN109596818B (zh) * | 2018-12-13 | 2024-03-19 | 丁蓉 | 一种基于电生理学分析当归四逆汤预防奥沙利铂神经毒性机制的研究方法 |
| WO2021156310A1 (en) * | 2020-02-04 | 2021-08-12 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Tafa4 polypeptide or polynucleotide for treating inflammatory disease |
| JP7729824B2 (ja) * | 2020-02-13 | 2025-08-26 | ザ ユナイテッド ステイツ オブ アメリカ， アズ リプレゼンテッド バイ ザ セクレタリー デパートメント オブ ヘルス アンド ヒューマン サービシーズ | マルガリン酸はｐｉｅｚｏ２媒介性疼痛を低減させる |
| EP4447991A1 (en) | 2021-12-17 | 2024-10-23 | Tafalgie Therapeutics | Peptides and methods for use in treating pain |
| AU2022419489A1 (en) * | 2021-12-20 | 2024-06-13 | Amgen Inc. | Dll3 binding peptides and uses thereof |
| AR129441A1 (es) | 2022-05-25 | 2024-08-28 | Tafalgie Therapeutics | Péptidos y métodos para el tratamiento del dolor |
| CN119584981A (zh) * | 2022-05-31 | 2025-03-07 | 纽洛可遗传学有限公司 | 用于治疗视网膜或黄斑疾病的组合物 |
| KR20250153765A (ko) | 2023-02-17 | 2025-10-27 | 나오스 인스티튜트 오브 라이프 사이언스 | 피부 내성 역치를 증가시킬 수 있는 생태생물학적 화합물의 선택 방법 |
| WO2025116606A1 (ko) * | 2023-11-30 | 2025-06-05 | 주식회사 뉴라클제네틱스 | 신규한 케모카인-유사 단백질 단편 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20090077680A1 (en) * | 2000-06-12 | 2009-03-19 | Alejandro Abuin | Genetically Engineered and Photyped Mice and Stem Cell Clones for Producing the Same |
| US20090136552A1 (en) * | 2004-07-30 | 2009-05-28 | Mette Gronborg | Growth factors nsg28, nsg30, and nsg32 |
-
2013
- 2013-05-06 EP EP13305592.1A patent/EP2801369A1/en not_active Withdrawn
-
2014
- 2014-05-06 ES ES14723045T patent/ES2813629T3/es active Active
- 2014-05-06 CN CN201480025716.5A patent/CN105209056B/zh active Active
- 2014-05-06 US US14/787,483 patent/US9884088B2/en active Active
- 2014-05-06 CA CA2910652A patent/CA2910652C/en active Active
- 2014-05-06 EP EP14723045.2A patent/EP2994157B1/en active Active
- 2014-05-06 CA CA3235916A patent/CA3235916A1/en active Pending
- 2014-05-06 DK DK14723045.2T patent/DK2994157T3/da active
- 2014-05-06 JP JP2016512345A patent/JP6487419B2/ja active Active
- 2014-05-06 WO PCT/EP2014/059247 patent/WO2014180853A1/en not_active Ceased
-
2017
- 2017-12-14 US US15/841,342 patent/US20180110829A1/en not_active Abandoned
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