ES2813629T3 - Compuestos de TAFA4 y usos de los mismos para tratar el dolor - Google Patents

Compuestos de TAFA4 y usos de los mismos para tratar el dolor Download PDF

Info

Publication number
ES2813629T3
ES2813629T3 ES14723045T ES14723045T ES2813629T3 ES 2813629 T3 ES2813629 T3 ES 2813629T3 ES 14723045 T ES14723045 T ES 14723045T ES 14723045 T ES14723045 T ES 14723045T ES 2813629 T3 ES2813629 T3 ES 2813629T3
Authority
ES
Spain
Prior art keywords
pain
tafa4
agonist
protein
amino acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
ES14723045T
Other languages
English (en)
Spanish (es)
Inventor
Aziz Moqrich
Marie-Claire Delfini
Annabelle Mantilleri
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aix Marseille Universite
Centre National de la Recherche Scientifique CNRS
Original Assignee
Aix Marseille Universite
Centre National de la Recherche Scientifique CNRS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aix Marseille Universite, Centre National de la Recherche Scientifique CNRS filed Critical Aix Marseille Universite
Application granted granted Critical
Publication of ES2813629T3 publication Critical patent/ES2813629T3/es
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A61K38/1709Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19Cytokines; Lymphokines; Interferons
    • A61K38/195Chemokines, e.g. RANTES
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01KANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027New or modified breeds of vertebrates
    • A01K67/0275Genetically modified vertebrates, e.g. transgenic
    • A01K67/0276Knock-out vertebrates
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00Anaesthetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/04Centrally acting analgesics, e.g. opioids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01KANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00Genetically modified animals
    • A01K2217/07Animals genetically altered by homologous recombination
    • A01K2217/075Animals genetically altered by homologous recombination inducing loss of function, i.e. knock out
    • A01K2217/077Animals genetically altered by homologous recombination inducing loss of function, i.e. knock out heterozygous knock out animals displaying phenotype
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01KANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00Animals characterised by species
    • A01K2227/10Mammal
    • A01K2227/105Murine
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01KANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00Animals characterised by purpose
    • A01K2267/03Animal model, e.g. for test or diseases
    • A01K2267/035Animal model for multifactorial diseases
    • A01K2267/0356Animal model for processes and diseases of the central nervous system, e.g. stress, learning, schizophrenia, pain, epilepsy

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Environmental Sciences (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Genetics & Genomics (AREA)
  • Toxicology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Marine Sciences & Fisheries (AREA)
  • Molecular Biology (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Animal Husbandry (AREA)
  • Biotechnology (AREA)
  • Anesthesiology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Rheumatology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
ES14723045T 2013-05-06 2014-05-06 Compuestos de TAFA4 y usos de los mismos para tratar el dolor Active ES2813629T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP13305592.1A EP2801369A1 (en) 2013-05-06 2013-05-06 TAFA4 compounds and uses thereof for treating pain
PCT/EP2014/059247 WO2014180853A1 (en) 2013-05-06 2014-05-06 Tafa4 compounds and uses thereof for treating pain

Publications (1)

Publication Number Publication Date
ES2813629T3 true ES2813629T3 (es) 2021-03-24

Family

ID=48428409

Family Applications (1)

Application Number Title Priority Date Filing Date
ES14723045T Active ES2813629T3 (es) 2013-05-06 2014-05-06 Compuestos de TAFA4 y usos de los mismos para tratar el dolor

Country Status (8)

Country Link
US (2) US9884088B2 (enExample)
EP (2) EP2801369A1 (enExample)
JP (1) JP6487419B2 (enExample)
CN (1) CN105209056B (enExample)
CA (2) CA2910652C (enExample)
DK (1) DK2994157T3 (enExample)
ES (1) ES2813629T3 (enExample)
WO (1) WO2014180853A1 (enExample)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016147825A1 (ja) * 2015-03-13 2016-09-22 シスメックス株式会社 被検物質の検出方法およびその方法に用いられる試薬キット
WO2019089465A1 (en) * 2017-10-30 2019-05-09 The Regents Of The University Of California Calibration free in-vivo measurement of analytes using electrochemical sensors
JP7171081B2 (ja) * 2018-04-24 2022-11-15 ニューラクル サイエンス カンパニー リミテッド 神経病性疼痛の治療のための配列類似性19、メンバーa5抗体を有する抗ファミリーの用途
ES2943136T3 (es) * 2018-09-27 2023-06-09 Inst Nat Sante Rech Med Polipéptido de TAFA4 para su uso para reducir la inflamación cutánea
CN109596818B (zh) * 2018-12-13 2024-03-19 丁蓉 一种基于电生理学分析当归四逆汤预防奥沙利铂神经毒性机制的研究方法
WO2021156310A1 (en) * 2020-02-04 2021-08-12 INSERM (Institut National de la Santé et de la Recherche Médicale) Tafa4 polypeptide or polynucleotide for treating inflammatory disease
JP7729824B2 (ja) * 2020-02-13 2025-08-26 ザ ユナイテッド ステイツ オブ アメリカ, アズ リプレゼンテッド バイ ザ セクレタリー デパートメント オブ ヘルス アンド ヒューマン サービシーズ マルガリン酸はpiezo2媒介性疼痛を低減させる
EP4447991A1 (en) 2021-12-17 2024-10-23 Tafalgie Therapeutics Peptides and methods for use in treating pain
AU2022419489A1 (en) * 2021-12-20 2024-06-13 Amgen Inc. Dll3 binding peptides and uses thereof
AR129441A1 (es) 2022-05-25 2024-08-28 Tafalgie Therapeutics Péptidos y métodos para el tratamiento del dolor
CN119584981A (zh) * 2022-05-31 2025-03-07 纽洛可遗传学有限公司 用于治疗视网膜或黄斑疾病的组合物
KR20250153765A (ko) 2023-02-17 2025-10-27 나오스 인스티튜트 오브 라이프 사이언스 피부 내성 역치를 증가시킬 수 있는 생태생물학적 화합물의 선택 방법
WO2025116606A1 (ko) * 2023-11-30 2025-06-05 주식회사 뉴라클제네틱스 신규한 케모카인-유사 단백질 단편

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20090077680A1 (en) * 2000-06-12 2009-03-19 Alejandro Abuin Genetically Engineered and Photyped Mice and Stem Cell Clones for Producing the Same
US20090136552A1 (en) * 2004-07-30 2009-05-28 Mette Gronborg Growth factors nsg28, nsg30, and nsg32

Also Published As

Publication number Publication date
US20160113996A1 (en) 2016-04-28
CA3235916A1 (en) 2014-11-13
US9884088B2 (en) 2018-02-06
EP2994157A1 (en) 2016-03-16
EP2801369A1 (en) 2014-11-12
CN105209056A (zh) 2015-12-30
DK2994157T3 (da) 2020-08-24
CA2910652A1 (en) 2014-11-13
JP6487419B2 (ja) 2019-03-20
CA2910652C (en) 2024-05-28
WO2014180853A1 (en) 2014-11-13
EP2994157B1 (en) 2020-07-01
US20180110829A1 (en) 2018-04-26
JP2016519138A (ja) 2016-06-30
CN105209056B (zh) 2018-01-23

Similar Documents

Publication Publication Date Title
ES2813629T3 (es) Compuestos de TAFA4 y usos de los mismos para tratar el dolor
Bączyk et al. Synaptic restoration by cAMP/PKA drives activity-dependent neuroprotection to motoneurons in ALS
Weir et al. Using an engineered glutamate-gated chloride channel to silence sensory neurons and treat neuropathic pain at the source
ES3009538T3 (en) Rodent cells having a disruption in a c9orf72 locus
ES2886855T3 (es) Composiciones farmacéuticas para tratar el dolor
Basu et al. Ventromedial hypothalamic nucleus subset stimulates tissue thermogenesis via preoptic area outputs
ES2617309T3 (es) Métodos y ensayos de tratamiento de sujetos con eliminación, mutación o expresión reducida de SHANK3
Dossat et al. Viral-mediated Zif268 expression in the prefrontal cortex protects against gonadectomy-induced working memory, long-term memory, and social interaction deficits in male rats
US20220370566A1 (en) Method and compositions for treating decreased cognitive ability
Iwasaki et al. A novel analgesic pathway from parvocellular oxytocin neurons to the periaqueductal gray
ES3036928T3 (en) Use of glial cell line-derived neurotrophic factor (gdnf) for the treatment of enteric neuropathies
Class et al. Patent application title: TAFA4 COMPOUNDS AND USES THEREOF FOR TREATING PAIN Inventors: Aziz Moqrich (Marseille, FR) Marie-Claire Delfini (Marseille, FR) Annabelle Mantilleri (Apt, FR)
WO2019126894A1 (es) Uso combinado de bumetanida con ácido valproico o una de sus sales farmacéuticamente aceptables, en el tratamiento de epilepsia refractaria
Xue et al. A DNA Nanomachine Reverses Mitochondrial Dysfunction by Cascaded Drug Release to Treat Osteoarthritis
Mousseau Microglial Panx1 is a Spinal Determinant of Arthritis Joint Pain
Fuller An Investigation into Noxious Mechanosensation, and the Role of Peripheral Neuron Subpopulations in Pain
Lin Cell Type-Specific FGF13 Regulation of Neuronal Function
DE ROCCO Pharmacological modulation of neuronal activity for the treatment of Rett syndrome
Ilaria et al. Voltage-independent GluN2A-type NMDA receptor Ca2+ signaling promotes audiogenic seizures, attentional and cognitive deficits in mice
Astrocyte-Mediated ASNTR 2023 Abstracts
Gandhi Organisation of Glutamatergic Inputs to Central Amygdala
Omer Characterizing Rare Disease-Causing Mutations in Genes Affecting Cation-Coupled Chloride Cotransport
Kosse Functional properties of GAD65 neurons in the lateral hypothalamus
Wang A spinal circuit for thermal pain regulated by ErbB4
Pomrenze Genetic dissection of an amygdala CRF circuit for fear and anxiety