|
JPS5144499B1
(enExample)
|
1970-08-29 |
1976-11-29 |
|
|
|
JPS5334319B2
(enExample)
|
1971-12-28 |
1978-09-20 |
|
|
|
JPS5717624B2
(enExample)
|
1974-04-17 |
1982-04-12 |
|
|
|
JPS59878B2
(ja)
|
1975-09-04 |
1984-01-09 |
松下電工株式会社 |
感知器
|
|
US4208479A
(en)
|
1977-07-14 |
1980-06-17 |
Syva Company |
Label modified immunoassays
|
|
US4474893A
(en)
|
1981-07-01 |
1984-10-02 |
The University of Texas System Cancer Center |
Recombinant monoclonal antibodies
|
|
US4444878A
(en)
|
1981-12-21 |
1984-04-24 |
Boston Biomedical Research Institute, Inc. |
Bispecific antibody determinants
|
|
JPS58201994A
(ja)
|
1982-05-21 |
1983-11-25 |
Hideaki Hagiwara |
抗原特異的ヒト免疫グロブリンの生産方法
|
|
US4816567A
(en)
|
1983-04-08 |
1989-03-28 |
Genentech, Inc. |
Recombinant immunoglobin preparations
|
|
GB8607679D0
(en)
|
1986-03-27 |
1986-04-30 |
Winter G P |
Recombinant dna product
|
|
JPH0234615Y2
(enExample)
|
1986-08-08 |
1990-09-18 |
|
|
|
JPH06104071B2
(ja)
|
1986-08-24 |
1994-12-21 |
財団法人化学及血清療法研究所 |
第▲ix▼因子コンホメ−シヨン特異性モノクロ−ナル抗体
|
|
AU600575B2
(en)
|
1987-03-18 |
1990-08-16 |
Sb2, Inc. |
Altered antibodies
|
|
US5004697A
(en)
|
1987-08-17 |
1991-04-02 |
Univ. Of Ca |
Cationized antibodies for delivery through the blood-brain barrier
|
|
US5670373A
(en)
|
1988-01-22 |
1997-09-23 |
Kishimoto; Tadamitsu |
Antibody to human interleukin-6 receptor
|
|
US5322678A
(en)
|
1988-02-17 |
1994-06-21 |
Neorx Corporation |
Alteration of pharmacokinetics of proteins by charge modification
|
|
US6010902A
(en)
|
1988-04-04 |
2000-01-04 |
Bristol-Meyers Squibb Company |
Antibody heteroconjugates and bispecific antibodies for use in regulation of lymphocyte activity
|
|
US5126250A
(en)
|
1988-09-28 |
1992-06-30 |
Eli Lilly And Company |
Method for the reduction of heterogeneity of monoclonal antibodies
|
|
IL89491A0
(en)
|
1988-11-17 |
1989-09-10 |
Hybritech Inc |
Bifunctional chimeric antibodies
|
|
DE3920358A1
(de)
|
1989-06-22 |
1991-01-17 |
Behringwerke Ag |
Bispezifische und oligospezifische, mono- und oligovalente antikoerperkonstrukte, ihre herstellung und verwendung
|
|
JPH0341033A
(ja)
|
1989-07-07 |
1991-02-21 |
Kyowa Hakko Kogyo Co Ltd |
安定なモチリン類含有製剤
|
|
GB8916400D0
(en)
|
1989-07-18 |
1989-09-06 |
Dynal As |
Modified igg3
|
|
DE68928946T2
(de)
|
1989-12-11 |
1999-10-21 |
Immunomedics, Inc. |
Verfahren zum aufspüren von diagnostischen oder therapeutischen mitteln durch antikörper
|
|
US5859205A
(en)
*
|
1989-12-21 |
1999-01-12 |
Celltech Limited |
Humanised antibodies
|
|
TW212184B
(enExample)
|
1990-04-02 |
1993-09-01 |
Takeda Pharm Industry Co Ltd |
|
|
JPH05184383A
(ja)
|
1990-06-19 |
1993-07-27 |
Dainabotsuto Kk |
二重特異性抗体
|
|
GB9015198D0
(en)
|
1990-07-10 |
1990-08-29 |
Brien Caroline J O |
Binding substance
|
|
AU665190B2
(en)
|
1990-07-10 |
1995-12-21 |
Cambridge Antibody Technology Limited |
Methods for producing members of specific binding pairs
|
|
JPH05199894A
(ja)
|
1990-08-20 |
1993-08-10 |
Takeda Chem Ind Ltd |
二重特異性抗体および抗体含有薬剤
|
|
KR100272077B1
(ko)
|
1990-08-29 |
2000-11-15 |
젠팜인터내셔날,인코포레이티드 |
이종 항체를 생산할 수 있는 전이유전자를 가진 인간이외의 동물
|
|
US5795965A
(en)
|
1991-04-25 |
1998-08-18 |
Chugai Seiyaku Kabushiki Kaisha |
Reshaped human to human interleukin-6 receptor
|
|
JPH05304992A
(ja)
|
1991-06-20 |
1993-11-19 |
Takeda Chem Ind Ltd |
ハイブリッド・モノクローナル抗体および抗体含有薬剤
|
|
US5637481A
(en)
|
1993-02-01 |
1997-06-10 |
Bristol-Myers Squibb Company |
Expression vectors encoding bispecific fusion proteins and methods of producing biologically active bispecific fusion proteins in a mammalian cell
|
|
US6136310A
(en)
|
1991-07-25 |
2000-10-24 |
Idec Pharmaceuticals Corporation |
Recombinant anti-CD4 antibodies for human therapy
|
|
JP3540315B2
(ja)
|
1991-09-23 |
2004-07-07 |
メディカル リサーチ カウンシル |
キメラ抗体の製造−組合せアプローチ
|
|
AU3178993A
(en)
|
1991-11-25 |
1993-06-28 |
Enzon, Inc. |
Multivalent antigen-binding proteins
|
|
US6027725A
(en)
|
1991-11-25 |
2000-02-22 |
Enzon, Inc. |
Multivalent antigen-binding proteins
|
|
ATE408012T1
(de)
|
1991-12-02 |
2008-09-15 |
Medical Res Council |
Herstellung von autoantikörpern auf phagenoberflächen ausgehend von antikörpersegmentbibliotheken
|
|
CA2124967C
(en)
|
1991-12-17 |
2008-04-08 |
Nils Lonberg |
Transgenic non-human animals capable of producing heterologous antibodies
|
|
US5667988A
(en)
|
1992-01-27 |
1997-09-16 |
The Scripps Research Institute |
Methods for producing antibody libraries using universal or randomized immunoglobulin light chains
|
|
JPH05203652A
(ja)
|
1992-01-28 |
1993-08-10 |
Fuji Photo Film Co Ltd |
抗体酵素免疫分析法
|
|
JPH05213775A
(ja)
|
1992-02-05 |
1993-08-24 |
Otsuka Pharmaceut Co Ltd |
Bfa抗体
|
|
US6749853B1
(en)
|
1992-03-05 |
2004-06-15 |
Board Of Regents, The University Of Texas System |
Combined methods and compositions for coagulation and tumor treatment
|
|
WO1993019172A1
(en)
|
1992-03-24 |
1993-09-30 |
Cambridge Antibody Technology Limited |
Methods for producing members of specific binding pairs
|
|
US6129914A
(en)
*
|
1992-03-27 |
2000-10-10 |
Protein Design Labs, Inc. |
Bispecific antibody effective to treat B-cell lymphoma and cell line
|
|
US5744446A
(en)
|
1992-04-07 |
1998-04-28 |
Emory University |
Hybrid human/animal factor VIII
|
|
WO1994002602A1
(en)
|
1992-07-24 |
1994-02-03 |
Cell Genesys, Inc. |
Generation of xenogeneic antibodies
|
|
US5639641A
(en)
|
1992-09-09 |
1997-06-17 |
Immunogen Inc. |
Resurfacing of rodent antibodies
|
|
ZA936260B
(en)
|
1992-09-09 |
1994-03-18 |
Smithkline Beecham Corp |
Novel antibodies for conferring passive immunity against infection by a pathogen in man
|
|
WO1994009817A1
(en)
|
1992-11-04 |
1994-05-11 |
City Of Hope |
Novel antibody construct
|
|
EP0672142B1
(en)
|
1992-12-04 |
2001-02-28 |
Medical Research Council |
Multivalent and multispecific binding proteins, their manufacture and use
|
|
EP0628078B1
(en)
|
1992-12-11 |
1999-12-08 |
The Dow Chemical Company |
Multivalent single chain antibodies
|
|
GB9313509D0
(en)
|
1993-06-30 |
1993-08-11 |
Medical Res Council |
Chemisynthetic libraries
|
|
JPH08510555A
(ja)
|
1993-07-01 |
1996-11-05 |
デイド、インターナショナル、インコーポレイテッド |
第x因子除去血漿の調製のための方法
|
|
UA40577C2
(uk)
|
1993-08-02 |
2001-08-15 |
Мерк Патент Гмбх |
Біспецифічна молекула, що використовується для лізису пухлинних клітин, спосіб її одержання, моноклональне антитіло (варіанти), фармацевтичний препарат, фармацевтичний набір (варіанти), спосіб видалення пухлинних клітин
|
|
IL107742A0
(en)
|
1993-11-24 |
1994-02-27 |
Yeda Res & Dev |
Chemically-modified binding proteins
|
|
WO1995015388A1
(en)
|
1993-12-03 |
1995-06-08 |
Medical Research Council |
Recombinant binding proteins and peptides
|
|
EP0732404A4
(en)
|
1993-12-03 |
1997-07-30 |
Asahi Chemical Ind |
NEW EXPRESSION DETECTION VECTOR
|
|
DE4419399C1
(de)
|
1994-06-03 |
1995-03-09 |
Gsf Forschungszentrum Umwelt |
Verfahren zur Herstellung von heterologen bispezifischen Antikörpern
|
|
US5945311A
(en)
|
1994-06-03 |
1999-08-31 |
GSF--Forschungszentrumfur Umweltund Gesundheit |
Method for producing heterologous bi-specific antibodies
|
|
US8017121B2
(en)
|
1994-06-30 |
2011-09-13 |
Chugai Seiyaku Kabushika Kaisha |
Chronic rheumatoid arthritis therapy containing IL-6 antagonist as effective component
|
|
ES2153483T3
(es)
|
1994-07-11 |
2001-03-01 |
Univ Texas |
Metodos y composiciones para la coagulacion especifica en los vasos tumorales.
|
|
EP0770628B9
(en)
|
1994-07-13 |
2007-02-28 |
Chugai Seiyaku Kabushiki Kaisha |
Reconstituted human antibody against human interleukin-8
|
|
ATE306930T1
(de)
|
1994-08-12 |
2005-11-15 |
Immunomedics Inc |
Für b-zell-lymphom und leukämiezellen spezifische immunkonjugate und humane antikörper
|
|
US6451523B1
(en)
|
1994-09-14 |
2002-09-17 |
Interneuron Pharmaceuticals, Inc. |
Detection of a leptin receptor variant and methods for regulating obesity
|
|
US6309636B1
(en)
|
1995-09-14 |
2001-10-30 |
Cancer Research Institute Of Contra Costa |
Recombinant peptides derived from the Mc3 anti-BA46 antibody, methods of use thereof, and methods of humanizing antibody peptides
|
|
AU700819B2
(en)
|
1994-10-07 |
1999-01-14 |
Chugai Seiyaku Kabushiki Kaisha |
Rheumatoid arthritis remedy containing IL-6 antagonist as effective component
|
|
WO1996012503A1
(en)
|
1994-10-21 |
1996-05-02 |
Chugai Seiyaku Kabushiki Kaisha |
Remedy for diseases caused by il-6 production
|
|
EP1241264A1
(en)
|
1994-12-02 |
2002-09-18 |
Chiron Corporation |
Monoclonal antibodies to colon cancer antigen
|
|
US6485943B2
(en)
|
1995-01-17 |
2002-11-26 |
The University Of Chicago |
Method for altering antibody light chain interactions
|
|
CN1097438C
(zh)
|
1995-02-28 |
2003-01-01 |
普罗格特-甘布尔公司 |
微生物稳定的非充气饮料产品的制备
|
|
US5731168A
(en)
|
1995-03-01 |
1998-03-24 |
Genentech, Inc. |
Method for making heteromultimeric polypeptides
|
|
JP4312259B2
(ja)
|
1995-04-27 |
2009-08-12 |
アムジェン フレモント インク. |
免疫したゼノマウス(XenoMouse)に由来するヒト抗体
|
|
EP0823941A4
(en)
|
1995-04-28 |
2001-09-19 |
Abgenix Inc |
HUMAN ANTIBODIES DERIVED FROM IMMUNIZED XENO MOUSES
|
|
DE69636015T2
(de)
|
1995-05-03 |
2007-01-04 |
Bioenhancementsments Ltd. |
Bispezifische antikörper in denen die bindungsfähigkeit durch eine mittels licht spaltbare gruppe reversibel inhibiert wird
|
|
US6018032A
(en)
|
1995-09-11 |
2000-01-25 |
Kyowa Hakko Kogyo Co., Ltd. |
Antibody against human interleukin-5-receptor α chain
|
|
US20020193571A1
(en)
|
1996-01-08 |
2002-12-19 |
Paul J. Carter |
Wsx receptor agonist antibodies
|
|
MA24512A1
(fr)
|
1996-01-17 |
1998-12-31 |
Univ Vermont And State Agrienl |
Procede pour la preparation d'agents anticoagulants utiles dans le traitement de la thrombose
|
|
FR2745008A1
(fr)
|
1996-02-20 |
1997-08-22 |
Ass Pour Le Dev De La Rech En |
Recepteur nucleaire de glucocorticoides modifie, fragments d'adn codant pour ledit recepteur et procedes dans lesquels ils sont mis en oeuvre
|
|
US5945231A
(en)
*
|
1996-03-26 |
1999-08-31 |
California Institute Of Technology |
Direct liquid-feed fuel cell with membrane electrolyte and manufacturing thereof
|
|
JP3032287U
(ja)
|
1996-06-10 |
1996-12-17 |
幸喜 高橋 |
人 形
|
|
US20020147326A1
(en)
|
1996-06-14 |
2002-10-10 |
Smithkline Beecham Corporation |
Hexameric fusion proteins and uses therefor
|
|
EP0938499A1
(en)
|
1996-07-19 |
1999-09-01 |
Amgen Inc. |
Analogs of cationic proteins
|
|
IL129164A
(en)
|
1996-09-26 |
2007-05-15 |
Chugai Pharmaceutical Co Ltd |
An antibody against peptides associated with human parathyroid hormone
|
|
JPH10165184A
(ja)
|
1996-12-16 |
1998-06-23 |
Tosoh Corp |
抗体、遺伝子及びキメラ抗体の製法
|
|
US5990286A
(en)
|
1996-12-18 |
1999-11-23 |
Techniclone, Inc. |
Antibodies with reduced net positive charge
|
|
US6323000B2
(en)
|
1996-12-20 |
2001-11-27 |
Clark A. Briggs |
Variant human α7 acetylcholine receptor subunit, and methods of production and uses thereof
|
|
JP2002501488A
(ja)
|
1997-03-20 |
2002-01-15 |
アメリカ合衆国 |
Cd22を保有する細胞および腫瘍へ標的化された、組換え抗体および免疫複合体
|
|
US6183744B1
(en)
|
1997-03-24 |
2001-02-06 |
Immunomedics, Inc. |
Immunotherapy of B-cell malignancies using anti-CD22 antibodies
|
|
US6306393B1
(en)
|
1997-03-24 |
2001-10-23 |
Immunomedics, Inc. |
Immunotherapy of B-cell malignancies using anti-CD22 antibodies
|
|
US20070059302A1
(en)
|
1997-04-07 |
2007-03-15 |
Genentech, Inc. |
Anti-vegf antibodies
|
|
US6884879B1
(en)
|
1997-04-07 |
2005-04-26 |
Genentech, Inc. |
Anti-VEGF antibodies
|
|
FR2761994B1
(fr)
|
1997-04-11 |
1999-06-18 |
Centre Nat Rech Scient |
Preparation de recepteurs membranaires a partir de baculovirus extracellulaires
|
|
US20030207346A1
(en)
|
1997-05-02 |
2003-11-06 |
William R. Arathoon |
Method for making multispecific antibodies having heteromultimeric and common components
|
|
US20020062010A1
(en)
|
1997-05-02 |
2002-05-23 |
Genentech, Inc. |
Method for making multispecific antibodies having heteromultimeric and common components
|
|
EP0979281B1
(en)
|
1997-05-02 |
2005-07-20 |
Genentech, Inc. |
A method for making multispecific antibodies having heteromultimeric and common components
|
|
DE19725586C2
(de)
|
1997-06-17 |
1999-06-24 |
Gsf Forschungszentrum Umwelt |
Verfahren zur Herstellung von Zellpräparaten zur Immunisierung mittels heterologer intakter bispezifischer und/oder trispezifischer Antikörper
|
|
WO1999002567A2
(en)
|
1997-07-08 |
1999-01-21 |
Board Of Regents, The University Of Texas System |
Compositions and methods for producing homoconjugates of antibodies which induce growth arrest or apoptosis of tumor cells
|
|
US5980893A
(en)
|
1997-07-17 |
1999-11-09 |
Beth Israel Deaconess Medical Center, Inc. |
Agonist murine monoclonal antibody as a stimulant for megakaryocytopoiesis
|
|
US6207805B1
(en)
|
1997-07-18 |
2001-03-27 |
University Of Iowa Research Foundation |
Prostate cell surface antigen-specific antibodies
|
|
US20020187150A1
(en)
|
1997-08-15 |
2002-12-12 |
Chugai Seiyaku Kabushiki Kaisha |
Preventive and/or therapeutic agent for systemic lupus erythematosus comprising anti-IL-6 receptor antibody as an active ingredient
|
|
US6342220B1
(en)
|
1997-08-25 |
2002-01-29 |
Genentech, Inc. |
Agonist antibodies
|
|
JP3992298B2
(ja)
|
1997-10-03 |
2007-10-17 |
中外製薬株式会社 |
天然ヒト型化抗体
|
|
PT1074268E
(pt)
|
1998-03-17 |
2008-02-28 |
Chugai Pharmaceutical Co Ltd |
Agentes profilácticos ou terapêuticos para doenças intestinais inflamatórias contendo anticorpos antagonistas do receptor il-6
|
|
JP3998419B2
(ja)
|
1998-04-03 |
2007-10-24 |
中外製薬株式会社 |
ヒト組織因子(tf)に対するヒト型化抗体およびヒト型化抗体の作製方法
|
|
DE19819846B4
(de)
|
1998-05-05 |
2016-11-24 |
Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts |
Multivalente Antikörper-Konstrukte
|
|
GB9809951D0
(en)
|
1998-05-08 |
1998-07-08 |
Univ Cambridge Tech |
Binding molecules
|
|
US7081360B2
(en)
|
1998-07-28 |
2006-07-25 |
Cadus Technologies, Inc. |
Expression of G protein-coupled receptors with altered ligand binding and/or coupling properties
|
|
CA2341029A1
(en)
|
1998-08-17 |
2000-02-24 |
Abgenix, Inc. |
Generation of modified molecules with increased serum half-lives
|
|
WO2000018806A1
(de)
|
1998-09-25 |
2000-04-06 |
Horst Lindhofer |
Bispezifische und trispezifische antikörper, die spezifisch mit induzierbaren oberflächenantigenen als operationelle zielstrukturen reagieren
|
|
ATE477273T1
(de)
|
1998-12-01 |
2010-08-15 |
Facet Biotech Corp |
Humanisierte antikoerper gegen gamma-interferon
|
|
US7286585B2
(en)
*
|
1998-12-21 |
2007-10-23 |
Finisar Corporation |
Low temperature grown layers with migration enhanced epitaxy adjacent to an InGaAsN(Sb) based active region
|
|
US6737056B1
(en)
|
1999-01-15 |
2004-05-18 |
Genentech, Inc. |
Polypeptide variants with altered effector function
|
|
BR0008758A
(pt)
|
1999-01-15 |
2001-12-04 |
Genentech Inc |
Variantes de polipeptìdeos parentais com funçãoefetora alterada, polipeptìdeos, composição ácidonucleico isolado, vetor, célula hospedeira,método para produzir uma variante depolipeptìdeo, método para o tratamento de umadesordem em mamìferos e método para produziruma região fc variante
|
|
US7183387B1
(en)
|
1999-01-15 |
2007-02-27 |
Genentech, Inc. |
Polypeptide variants with altered effector function
|
|
US6897044B1
(en)
|
1999-01-28 |
2005-05-24 |
Biogen Idec, Inc. |
Production of tetravalent antibodies
|
|
US6972125B2
(en)
|
1999-02-12 |
2005-12-06 |
Genetics Institute, Llc |
Humanized immunoglobulin reactive with B7-2 and methods of treatment therewith
|
|
CO5280147A1
(es)
|
1999-05-18 |
2003-05-30 |
Smithkline Beecham Corp |
Anticuerpo humano monoclonal
|
|
SK782002A3
(en)
|
1999-07-21 |
2003-08-05 |
Lexigen Pharm Corp |
FC fusion proteins for enhancing the immunogenicity of protein and peptide antigens
|
|
AT411997B
(de)
|
1999-09-14 |
2004-08-26 |
Baxter Ag |
Faktor ix/faktor ixa aktivierende antikörper und antikörper-derivate
|
|
SE9903895D0
(sv)
|
1999-10-28 |
1999-10-28 |
Active Biotech Ab |
Novel compounds
|
|
WO2002004021A1
(en)
|
2000-07-12 |
2002-01-17 |
Idec Pharmaceuticals Corporation |
Treatment of b cell malignancies using combination of b cell depleting antibody and immune modulating antibody related applications
|
|
US20020028178A1
(en)
|
2000-07-12 |
2002-03-07 |
Nabil Hanna |
Treatment of B cell malignancies using combination of B cell depleting antibody and immune modulating antibody related applications
|
|
AU1290001A
(en)
|
1999-11-18 |
2001-05-30 |
Oxford Biomedica (Uk) Limited |
Antibodies
|
|
AU2578401A
(en)
|
1999-12-14 |
2001-06-25 |
Burnham Institute, The |
Bcl-g polypeptides, encoding nucleic acids and methods of use
|
|
AU2001256174A1
(en)
|
2000-03-01 |
2001-09-12 |
Christoph Gasche |
Mammalian interleukin-10 (il-10) receptor variants
|
|
TWI242043B
(en)
|
2000-03-10 |
2005-10-21 |
Chugai Pharmaceutical Co Ltd |
Polypeptide inducing apoptosis
|
|
PT1265914E
(pt)
|
2000-03-22 |
2008-04-08 |
Geneprint Inc |
Polipéptidos relacionados com wnt-1 e ácidos nucleicos que codificam estes polipéptidos
|
|
EP1283722A1
(en)
|
2000-03-31 |
2003-02-19 |
Idec Pharmaceuticals Corporation |
Combined use of anti-cytokine antibodies or antagonists and anti-cd20 for the treatment of b cell lymphoma
|
|
JP2004505609A
(ja)
*
|
2000-04-03 |
2004-02-26 |
オックスフォード グリコサイエンシズ(ユーケー) リミテッド |
核酸分子、ポリペプチド、ならびにアルツハイマー病の診断および処置を含むそれらの使用
|
|
AU2001246934A1
(en)
|
2000-04-17 |
2001-10-30 |
Chugai Seiyaku Kabushiki Kaisha |
Agonist antibodies
|
|
WO2001082899A2
(en)
|
2000-05-03 |
2001-11-08 |
Mbt Munich Biotechnology Ag |
Cationic diagnostic, imaging and therapeutic agents associated with activated vascular sites
|
|
WO2001090192A2
(en)
|
2000-05-24 |
2001-11-29 |
Imclone Systems Incorporated |
Bispecific immunoglobulin-like antigen binding proteins and method of production
|
|
CA2411102A1
(en)
|
2000-06-20 |
2001-12-27 |
Idec Pharmaceutical Corporation |
Cold anti-cd20 antibody/radiolabeled anti-cd22 antibody combination
|
|
JP4908721B2
(ja)
|
2000-07-17 |
2012-04-04 |
中外製薬株式会社 |
生理活性を有するリガンドのスクリーニング方法
|
|
CN1592645A
(zh)
|
2000-09-18 |
2005-03-09 |
拜奥根Idec公司 |
使用b细胞耗尽/免疫调节抗体组合治疗自身免疫病的联合疗法
|
|
IL155002A0
(en)
|
2000-10-12 |
2003-10-31 |
Genentech Inc |
Reduced-viscosity concentrated protein formulations
|
|
AU1091802A
(en)
|
2000-10-20 |
2002-04-29 |
Chugai Pharmaceutical Co Ltd |
Degraded agonist antibody
|
|
EP1327680B1
(en)
|
2000-10-20 |
2008-04-02 |
Chugai Seiyaku Kabushiki Kaisha |
Modified tpo agonist antibody
|
|
KR100870123B1
(ko)
|
2000-10-20 |
2008-11-25 |
츄가이 세이야꾸 가부시키가이샤 |
저분자화 아고니스트 항체
|
|
ATE391174T1
(de)
|
2000-10-20 |
2008-04-15 |
Chugai Pharmaceutical Co Ltd |
Modifizierter tpo-agonisten antikörper
|
|
JP4889187B2
(ja)
|
2000-10-27 |
2012-03-07 |
中外製薬株式会社 |
Il−6アンタゴニストを有効成分として含有する血中mmp−3濃度低下剤
|
|
PT1355919E
(pt)
|
2000-12-12 |
2011-03-02 |
Medimmune Llc |
Moléculas com semivida longa, composições que as contêm e suas utilizações
|
|
BR0207854A
(pt)
|
2001-03-07 |
2004-08-24 |
Merck Patent Gmbh |
Tecnologia de expressão para proteìnas contendo uma porção de anticorpo de isotipo hìbrido
|
|
AU2002307062A1
(en)
|
2001-04-02 |
2002-10-15 |
Purdue Pharma L.P. |
Thrombopoietin (tpo) synthebody for stimulation of platelet production
|
|
UA80091C2
(en)
|
2001-04-02 |
2007-08-27 |
Chugai Pharmaceutical Co Ltd |
Remedies for infant chronic arthritis-relating diseases and still's disease which contain an interleukin-6 (il-6) antagonist
|
|
CN1294148C
(zh)
|
2001-04-11 |
2007-01-10 |
中国科学院遗传与发育生物学研究所 |
环状单链三特异抗体
|
|
UA83791C2
(ru)
|
2001-04-13 |
2008-08-26 |
Байоджен Айдек Ма Инк. |
Антитело против vla-1, фармацевтическая композиция, которая его содержит, и из применение для лечения индивидуума с иммунологическим расстройством, опосредованным vla-1
|
|
EP2208784B1
(en)
|
2001-06-22 |
2013-01-02 |
Chugai Seiyaku Kabushiki Kaisha |
Cell proliferation inhibitors containing anti-glypican 3 antibody
|
|
DE60237282D1
(de)
|
2001-06-28 |
2010-09-23 |
Domantis Ltd |
Doppelspezifischer ligand und dessen verwendung
|
|
US20030049203A1
(en)
|
2001-08-31 |
2003-03-13 |
Elmaleh David R. |
Targeted nucleic acid constructs and uses related thereto
|
|
MXPA04003535A
(es)
|
2001-10-15 |
2005-06-20 |
Immunomedics Inc |
Proteinas de enlace para objetivos directos.
|
|
ATE430580T1
(de)
|
2001-10-25 |
2009-05-15 |
Genentech Inc |
Glycoprotein-zusammensetzungen
|
|
US20030190705A1
(en)
|
2001-10-29 |
2003-10-09 |
Sunol Molecular Corporation |
Method of humanizing immune system molecules
|
|
DE10156482A1
(de)
|
2001-11-12 |
2003-05-28 |
Gundram Jung |
Bispezifisches Antikörper-Molekül
|
|
WO2003068801A2
(en)
|
2002-02-11 |
2003-08-21 |
Genentech, Inc. |
Antibody variants with faster antigen association rates
|
|
US20040002587A1
(en)
|
2002-02-20 |
2004-01-01 |
Watkins Jeffry D. |
Fc region variants
|
|
WO2003074679A2
(en)
|
2002-03-01 |
2003-09-12 |
Xencor |
Antibody optimization
|
|
US8188231B2
(en)
|
2002-09-27 |
2012-05-29 |
Xencor, Inc. |
Optimized FC variants
|
|
AU2003227504A1
(en)
|
2002-04-15 |
2003-10-27 |
Chugai Seiyaku Kabushiki Kaisha |
METHOD OF CONSTRUCTING scDb LIBRARY
|
|
EP1505148B1
(en)
|
2002-04-26 |
2009-04-15 |
Chugai Seiyaku Kabushiki Kaisha |
Methods of screening for agonistic antibodies
|
|
JP2004086862A
(ja)
|
2002-05-31 |
2004-03-18 |
Celestar Lexico-Sciences Inc |
タンパク質相互作用情報処理装置、タンパク質相互作用情報処理方法、プログラム、および、記録媒体
|
|
US20050130224A1
(en)
|
2002-05-31 |
2005-06-16 |
Celestar Lexico- Sciences, Inc. |
Interaction predicting device
|
|
AU2003239197A1
(en)
|
2002-06-07 |
2003-12-22 |
The Government Of The United States Of America, As Represented By The Secretary Of The Department Of |
Novel stable anti-cd22 antibodies
|
|
WO2003105757A2
(en)
|
2002-06-12 |
2003-12-24 |
Genencor International, Inc. |
Methods and compositions for milieu-dependent binding of a targeted agent to a target
|
|
DK1517921T3
(da)
|
2002-06-28 |
2006-10-09 |
Domantis Ltd |
Immunglobulin-enkeltvariable antigen-bindende domæner og dobbeltspecifikke konstruktioner deraf
|
|
SI1523496T1
(sl)
|
2002-07-18 |
2011-11-30 |
Merus B V |
Rekombinantno proizvajanje zmesi protiteles
|
|
JP2005535341A
(ja)
|
2002-08-15 |
2005-11-24 |
エピトミスク インコーポレーティッド |
ヒト化ウサギ抗体
|
|
AU2003257536A1
(en)
|
2002-08-27 |
2004-03-19 |
Chugai Seiyaku Kabushiki Kaisha |
Method of stabilizing protein solution preparation
|
|
US20060235208A1
(en)
|
2002-09-27 |
2006-10-19 |
Xencor, Inc. |
Fc variants with optimized properties
|
|
JPWO2004033499A1
(ja)
|
2002-10-11 |
2006-02-09 |
中外製薬株式会社 |
細胞死誘導剤
|
|
US7217797B2
(en)
|
2002-10-15 |
2007-05-15 |
Pdl Biopharma, Inc. |
Alteration of FcRn binding affinities or serum half-lives of antibodies by mutagenesis
|
|
GB0224082D0
(en)
*
|
2002-10-16 |
2002-11-27 |
Celltech R&D Ltd |
Biological products
|
|
WO2004035607A2
(en)
|
2002-10-17 |
2004-04-29 |
Genmab A/S |
Human monoclonal antibodies against cd20
|
|
CN101014364B
(zh)
|
2002-12-24 |
2012-01-18 |
里纳特神经系统学公司 |
抗ngf抗体及其使用方法
|
|
AU2003303543A1
(en)
|
2002-12-26 |
2004-07-29 |
Chugai Seiyaku Kabushiki Kaisha |
Agonist antibody against heteroreceptor
|
|
WO2004065611A1
(ja)
|
2003-01-21 |
2004-08-05 |
Chugai Seiyaku Kabushiki Kaisha |
抗体の軽鎖スクリーニング方法
|
|
US7223393B2
(en)
|
2003-02-07 |
2007-05-29 |
Pdl Biopharma, Inc |
Amphiregulin antibodies and their use to treat cancer and psoriasis
|
|
US20090010920A1
(en)
|
2003-03-03 |
2009-01-08 |
Xencor, Inc. |
Fc Variants Having Decreased Affinity for FcyRIIb
|
|
WO2004081048A1
(ja)
|
2003-03-13 |
2004-09-23 |
Chugai Seiyaku Kabushiki Kaisha |
変異受容体に対するアゴニスト活性を有するリガンド
|
|
JP2004279086A
(ja)
|
2003-03-13 |
2004-10-07 |
Konica Minolta Holdings Inc |
放射線画像変換パネル及び放射線画像変換パネルの製造方法
|
|
JPWO2004087763A1
(ja)
|
2003-03-31 |
2006-07-27 |
中外製薬株式会社 |
Cd22に対する改変抗体およびその利用
|
|
GB2400851B
(en)
|
2003-04-25 |
2004-12-15 |
Bioinvent Int Ab |
Identifying binding of a polypeptide to a polypeptide target
|
|
GB2401040A
(en)
|
2003-04-28 |
2004-11-03 |
Chugai Pharmaceutical Co Ltd |
Method for treating interleukin-6 related diseases
|
|
EP2395017A3
(en)
*
|
2003-05-30 |
2012-12-19 |
Merus B.V. |
Design and use of paired variable regions of specific binding molecules
|
|
EP2272868B1
(en)
|
2003-06-05 |
2015-03-04 |
Genentech, Inc. |
Combination therapy for B cell disorders
|
|
US8597911B2
(en)
|
2003-06-11 |
2013-12-03 |
Chugai Seiyaku Kabushiki Kaisha |
Process for producing antibodies
|
|
EP1636264A2
(en)
|
2003-06-24 |
2006-03-22 |
MERCK PATENT GmbH |
Tumour necrosis factor receptor molecules with reduced immunogenicity
|
|
US20050033029A1
(en)
|
2003-06-30 |
2005-02-10 |
Jin Lu |
Engineered anti-target immunoglobulin derived proteins, compositions, methods and uses
|
|
US7297336B2
(en)
|
2003-09-12 |
2007-11-20 |
Baxter International Inc. |
Factor IXa specific antibodies displaying factor VIIIa like activity
|
|
JP2005101105A
(ja)
|
2003-09-22 |
2005-04-14 |
Canon Inc |
位置決め装置、露光装置、デバイス製造方法
|
|
JP2005112514A
(ja)
|
2003-10-06 |
2005-04-28 |
Tadano Ltd |
伸縮ブーム
|
|
AU2003271174A1
(en)
|
2003-10-10 |
2005-04-27 |
Chugai Seiyaku Kabushiki Kaisha |
Double specific antibodies substituting for functional protein
|
|
EP2311945A1
(en)
|
2003-10-14 |
2011-04-20 |
Chugai Seiyaku Kabushiki Kaisha |
Bispecific antibodies substituting for functional proteins
|
|
WO2005063815A2
(en)
|
2003-11-12 |
2005-07-14 |
Biogen Idec Ma Inc. |
Fcϝ receptor-binding polypeptide variants and methods related thereto
|
|
CA2545603A1
(en)
|
2003-11-12 |
2005-05-26 |
Biogen Idec Ma Inc. |
Neonatal fc receptor (fcrn)-binding polypeptide variants, dimeric fc binding proteins and methods related thereto
|
|
EP1701979A2
(en)
|
2003-12-03 |
2006-09-20 |
Xencor, Inc. |
Optimized antibodies that target the epidermal growth factor receptor
|
|
ZA200604620B
(en)
|
2003-12-10 |
2007-10-31 |
Medarex Inc |
IP-10 antibodies and their uses
|
|
DK1711207T3
(da)
|
2003-12-10 |
2013-03-11 |
Medarex Inc |
Interferon-alpha-antistoffer og anvendelse heraf
|
|
TW200530266A
(en)
|
2003-12-12 |
2005-09-16 |
Chugai Pharmaceutical Co Ltd |
Method of reinforcing antibody activity
|
|
TW200530269A
(en)
|
2003-12-12 |
2005-09-16 |
Chugai Pharmaceutical Co Ltd |
Anti-Mpl antibodies
|
|
EP1710255A4
(en)
|
2003-12-12 |
2008-09-24 |
Chugai Pharmaceutical Co Ltd |
MODIFIED ANTIBODIES RECOGNIZING A TRIMER OR LARGER RECEPTOR
|
|
WO2005056602A1
(ja)
|
2003-12-12 |
2005-06-23 |
Chugai Seiyaku Kabushiki Kaisha |
アゴニスト活性を有する改変抗体のスクリーニング方法
|
|
AR048210A1
(es)
|
2003-12-19 |
2006-04-12 |
Chugai Pharmaceutical Co Ltd |
Un agente preventivo para la vasculitis.
|
|
EP1697748A4
(en)
|
2003-12-22 |
2007-07-04 |
Centocor Inc |
METHODS FOR GENERATING MULTIMEDIA MOLECULES
|
|
RU2377254C2
(ru)
|
2003-12-25 |
2009-12-27 |
Кирин Фарма Кабусики Кайся |
Мутанты анти-cd40 антитела
|
|
US20050266425A1
(en)
|
2003-12-31 |
2005-12-01 |
Vaccinex, Inc. |
Methods for producing and identifying multispecific antibodies
|
|
CN1956738B
(zh)
|
2004-01-09 |
2013-05-29 |
辉瑞大药厂 |
MAdCAM抗体
|
|
CN1330448C
(zh)
*
|
2004-02-25 |
2007-08-08 |
苏州宝时得电动工具有限公司 |
往复式电动工具的往复杆平衡机构
|
|
EP2053062A1
(en)
|
2004-03-24 |
2009-04-29 |
Xencor, Inc. |
Immunoglobin variants outside the Fc region
|
|
AR048335A1
(es)
|
2004-03-24 |
2006-04-19 |
Chugai Pharmaceutical Co Ltd |
Agentes terapeuticos para trastornos del oido interno que contienen un antagonista de il- 6 como un ingrediente activo
|
|
WO2005112564A2
(en)
|
2004-04-15 |
2005-12-01 |
The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services |
Germline and sequence variants of humanized antibodies and methods of making and using them
|
|
TW200605906A
(en)
|
2004-05-11 |
2006-02-16 |
Chugai Pharmaceutical Co Ltd |
Remedy for thrombopenia
|
|
ES2526343T3
(es)
|
2004-06-03 |
2015-01-09 |
Novimmune Sa |
Anticuerpos anti-CD3 y métodos de uso de los mismos
|
|
KR100620554B1
(ko)
|
2004-06-05 |
2006-09-06 |
한국생명공학연구원 |
Tag-72에 대한 인간화 항체
|
|
AR049390A1
(es)
|
2004-06-09 |
2006-07-26 |
Wyeth Corp |
Anticuerpos contra la interleuquina-13 humana y usos de los mismos
|
|
US20060019342A1
(en)
|
2004-06-25 |
2006-01-26 |
Medimmune, Inc. |
Increasing the production of recombinant antibodies in mammalian cells by site-directed mutagenesis
|
|
DE102004032634A1
(de)
|
2004-07-06 |
2006-02-16 |
Sms Demag Ag |
Verfahren und Einrichtung zum Messen und Regeln der Planheit und/oder der Bandspannungen eines Edelstahlbandes oder einer Edelstahlfolie beim Kaltwalzen in einem Vielwalzengerüst, insbesondere in einem 20-Walzen-Sendizimir-Walzwerk
|
|
DE602005024502D1
(de)
|
2004-07-09 |
2010-12-16 |
Chugai Pharmaceutical Co Ltd |
Anti-glypican-3-antikörper
|
|
BRPI0510674A
(pt)
|
2004-07-15 |
2007-12-26 |
Xencor Inc |
variantes fc otimizadas
|
|
BRPI0514068B8
(pt)
|
2004-08-04 |
2021-05-25 |
Applied Molecular Evolution Inc |
anticorpo anti-cd20, e, composição farmacêutica
|
|
CA2577082A1
(en)
*
|
2004-09-02 |
2006-03-16 |
Genentech, Inc. |
Heteromultimeric molecules
|
|
CA2579142A1
(en)
|
2004-09-13 |
2006-03-23 |
Macrogenics, Inc. |
Humanized antibodies against west nile virus and therapeutic and prophylactic uses thereof
|
|
US20060074225A1
(en)
|
2004-09-14 |
2006-04-06 |
Xencor, Inc. |
Monomeric immunoglobulin Fc domains
|
|
EP1799718A1
(en)
|
2004-09-14 |
2007-06-27 |
National Institute for Biological Standards and Control (NIBSC) |
Vaccine
|
|
TWI380996B
(zh)
|
2004-09-17 |
2013-01-01 |
Hoffmann La Roche |
抗ox40l抗體
|
|
US7563443B2
(en)
|
2004-09-17 |
2009-07-21 |
Domantis Limited |
Monovalent anti-CD40L antibody polypeptides and compositions thereof
|
|
EP1810979B1
(en)
|
2004-09-22 |
2012-06-20 |
Kyowa Hakko Kirin Co., Ltd. |
STABILIZED HUMAN IgG4 ANTIBODIES
|
|
WO2006047350A2
(en)
|
2004-10-21 |
2006-05-04 |
Xencor, Inc. |
IgG IMMUNOGLOBULIN VARIANTS WITH OPTIMIZED EFFECTOR FUNCTION
|
|
WO2006047340A2
(en)
|
2004-10-22 |
2006-05-04 |
Amgen Inc. |
Methods for refolding of recombinant antibodies
|
|
US7462697B2
(en)
|
2004-11-08 |
2008-12-09 |
Epitomics, Inc. |
Methods for antibody engineering
|
|
AU2005335714B2
(en)
|
2004-11-10 |
2012-07-26 |
Macrogenics, Inc. |
Engineering Fc antibody regions to confer effector function
|
|
WO2006065208A1
(en)
|
2004-12-14 |
2006-06-22 |
Ge Healthcare Bio-Sciences Ab |
Purification of immunoglobulins
|
|
US8728828B2
(en)
|
2004-12-22 |
2014-05-20 |
Ge Healthcare Bio-Sciences Ab |
Purification of immunoglobulins
|
|
EP1829961A4
(en)
|
2004-12-22 |
2008-06-04 |
Chugai Pharmaceutical Co Ltd |
PROCESS FOR PREPARING ANTIBODY USING A CELL WHOSE FUCOSE CARRIER FUNCTION IS INHIBITED
|
|
EP1833510A4
(en)
|
2004-12-27 |
2010-02-10 |
Progenics Pharmaceuticals Neva |
ORAL ADMINISTRATION ANTITOXIN ANTIBODIES AND METHODS OF MAKING AND USING THE SAME
|
|
EP3026063A1
(en)
|
2004-12-28 |
2016-06-01 |
Innate Pharma S.A. |
Monoclonal antibodies against nkg2a
|
|
WO2006076594A2
(en)
|
2005-01-12 |
2006-07-20 |
Xencor, Inc. |
Antibodies and fc fusion proteins with altered immunogenicity
|
|
US8716451B2
(en)
|
2005-01-12 |
2014-05-06 |
Kyowa Hakko Kirin Co., Ltd |
Stabilized human IgG2 and IgG3 antibodies
|
|
WO2006105338A2
(en)
|
2005-03-31 |
2006-10-05 |
Xencor, Inc. |
Fc VARIANTS WITH OPTIMIZED PROPERTIES
|
|
US9493569B2
(en)
|
2005-03-31 |
2016-11-15 |
Chugai Seiyaku Kabushiki Kaisha |
Structural isomers of sc(Fv)2
|
|
JP5620626B2
(ja)
|
2005-03-31 |
2014-11-05 |
中外製薬株式会社 |
会合制御によるポリペプチド製造方法
|
|
EP1876236B9
(en)
|
2005-04-08 |
2015-02-25 |
Chugai Seiyaku Kabushiki Kaisha |
Antibody substituting for function of blood coagulation factor viii
|
|
US7737115B2
(en)
|
2005-04-15 |
2010-06-15 |
Genetech, Inc. |
HGF beta chain variants
|
|
JP5255435B2
(ja)
|
2005-04-26 |
2013-08-07 |
メディミューン,エルエルシー |
ヒンジドメイン操作による抗体エフェクター機能の調節
|
|
AU2006244445B2
(en)
|
2005-05-05 |
2013-04-18 |
Duke University |
Anti-CD19 antibody therapy for autoimmune disease
|
|
TW200718780A
(en)
|
2005-06-10 |
2007-05-16 |
Chugai Pharmaceutical Co Ltd |
Sc(Fv)2 site-directed mutant
|
|
KR101360671B1
(ko)
|
2005-06-10 |
2014-02-07 |
추가이 세이야쿠 가부시키가이샤 |
sc(Fv)2를 함유하는 의약조성물
|
|
EP1908482B1
(en)
|
2005-06-10 |
2017-09-06 |
Chugai Seiyaku Kabushiki Kaisha |
Stabilizer for protein preparation comprising meglumine and use thereof
|
|
WO2007002543A2
(en)
*
|
2005-06-23 |
2007-01-04 |
Medimmune, Inc. |
Antibody formulations having optimized aggregation and fragmentation profiles
|
|
JP2009500458A
(ja)
|
2005-07-11 |
2009-01-08 |
マクロジェニクス,インコーポレーテッド |
ヒト化抗cd16a抗体を用いる自己免疫疾患の治療方法
|
|
PL1919503T3
(pl)
|
2005-08-10 |
2015-04-30 |
Macrogenics Inc |
Identyfikacja i inżynieria przeciwciał ze zmiennymi regionami FC oraz sposoby ich stosowania
|
|
PT2407486T
(pt)
|
2005-08-19 |
2018-02-21 |
Univ Pennsylvania |
Anticorpos antagonistas contra gdf-8 e utilizações no tratamento de ela e outros distúrbios associados a gdf-8
|
|
EP1928916A2
(en)
|
2005-09-29 |
2008-06-11 |
Viral Logic Systems Technology Corp. |
Immunomodulatory compositions and uses therefor
|
|
WO2007043641A1
(ja)
|
2005-10-14 |
2007-04-19 |
Fukuoka University |
膵島移植における移植膵島障害抑制剤
|
|
BRPI0617664B8
(pt)
|
2005-10-21 |
2021-05-25 |
Chugai Pharmaceutical Co Ltd |
uso de um anticorpo que reconhece a il-6 para a produção de uma composição farmacêutica para tratar o enfarte do miocárdio ou suprimir a remodelagem ventricular esquerda depois do enfarte do miocárdio
|
|
WO2007060411A1
(en)
|
2005-11-24 |
2007-05-31 |
Ucb Pharma S.A. |
Anti-tnf alpha antibodies which selectively inhibit tnf alpha signalling through the p55r
|
|
EP1820513A1
(en)
|
2006-02-15 |
2007-08-22 |
Trion Pharma Gmbh |
Destruction of tumor cells expressing low to medium levels of tumor associated target antigens by trifunctional bispecific antibodies
|
|
TW200745163A
(en)
|
2006-02-17 |
2007-12-16 |
Syntonix Pharmaceuticals Inc |
Peptides that block the binding of IgG to FcRn
|
|
EP2006380A4
(en)
|
2006-03-23 |
2010-08-11 |
Kyowa Hakko Kirin Co Ltd |
AGONIST ANTIBODY AGAINST THE HUMAN THROMBOPOIETINE RECEPTOR
|
|
WO2007110205A2
(en)
|
2006-03-24 |
2007-10-04 |
Merck Patent Gmbh |
Engineered heterodimeric protein domains
|
|
EP2009101B1
(en)
|
2006-03-31 |
2017-10-25 |
Chugai Seiyaku Kabushiki Kaisha |
Antibody modification method for purifying bispecific antibody
|
|
DK2006381T3
(en)
|
2006-03-31 |
2016-02-22 |
Chugai Pharmaceutical Co Ltd |
PROCEDURE FOR REGULATING ANTIBODIES BLOOD PHARMACOKINETICS
|
|
WO2007116962A1
(ja)
|
2006-04-07 |
2007-10-18 |
Osaka University |
筋再生促進剤
|
|
JP2009539841A
(ja)
|
2006-06-06 |
2009-11-19 |
トラークス,インコーポレイテッド |
自己免疫疾患の治療における抗cd3抗体の投与
|
|
PE20080333A1
(es)
|
2006-06-08 |
2008-06-15 |
Chugai Pharmaceutical Co Ltd |
Agentes para prevenir o tratar enfermedades inflamatorias
|
|
WO2007147901A1
(en)
|
2006-06-22 |
2007-12-27 |
Novo Nordisk A/S |
Production of bispecific antibodies
|
|
US20100034194A1
(en)
|
2006-10-11 |
2010-02-11 |
Siemens Communications Inc. |
Eliminating unreachable subscribers in voice-over-ip networks
|
|
WO2008090960A1
(ja)
|
2007-01-24 |
2008-07-31 |
Kyowa Hakko Kirin Co., Ltd. |
ガングリオシドgm2に特異的に結合する遺伝子組換え抗体組成物
|
|
WO2008092117A2
(en)
|
2007-01-25 |
2008-07-31 |
Xencor, Inc. |
Immunoglobulins with modifications in the fcr binding region
|
|
AU2008234248C1
(en)
|
2007-03-29 |
2015-01-22 |
Genmab A/S |
Bispecific antibodies and methods for production thereof
|
|
WO2008145141A1
(en)
|
2007-05-31 |
2008-12-04 |
Genmab A/S |
Method for extending the half-life of exogenous or endogenous soluble molecules
|
|
WO2008145142A1
(en)
|
2007-05-31 |
2008-12-04 |
Genmab A/S |
Stable igg4 antibodies
|
|
CA2691618A1
(en)
|
2007-06-29 |
2009-01-08 |
Schering Corporation |
Mdl-1 uses
|
|
EP2031064A1
(de)
|
2007-08-29 |
2009-03-04 |
Boehringer Ingelheim Pharma GmbH & Co. KG |
Verfahren zur Steigerung von Proteintitern
|
|
EP2197911A2
(en)
|
2007-09-14 |
2010-06-23 |
Amgen Inc. |
Homogeneous antibody populations
|
|
DK2202245T3
(en)
*
|
2007-09-26 |
2016-11-21 |
Chugai Pharmaceutical Co Ltd |
A method of modifying an antibody isoelectric point VIA amino acid substitution in CDR
|
|
ES2687808T3
(es)
|
2007-09-26 |
2018-10-29 |
Chugai Seiyaku Kabushiki Kaisha |
Región constante de anticuerpo modificado
|
|
WO2009041734A1
(ja)
|
2007-09-26 |
2009-04-02 |
Kyowa Hakko Kirin Co., Ltd. |
ヒトトロンボポエチン受容体に対するアゴニスト抗体
|
|
RU2505603C2
(ru)
|
2007-09-26 |
2014-01-27 |
Чугаи Сейяку Кабусики Кайся |
Антитело против рецептора il-6
|
|
CN101809162B
(zh)
|
2007-09-28 |
2013-06-05 |
中外制药株式会社 |
血浆中动力学被改善的磷脂酰肌醇蛋白聚糖3抗体
|
|
JO3076B1
(ar)
|
2007-10-17 |
2017-03-15 |
Janssen Alzheimer Immunotherap |
نظم العلاج المناعي المعتمد على حالة apoe
|
|
EP2203180B1
(en)
|
2007-10-22 |
2012-11-21 |
Merck Serono S.A. |
Single ifn-beta fused to a mutated igg fc fragment
|
|
MX337081B
(es)
|
2007-12-05 |
2016-02-10 |
Chugai Pharmaceutical Co Ltd |
Anticuerpo anti-nr10 y su uso.
|
|
AU2008338313B2
(en)
|
2007-12-18 |
2014-01-16 |
Bioalliance C.V. |
Antibodies recognizing a carbohydrate containing epitope on CD-43 and CEA expressed on cancer cells and methods using same
|
|
US20090162359A1
(en)
|
2007-12-21 |
2009-06-25 |
Christian Klein |
Bivalent, bispecific antibodies
|
|
US8242247B2
(en)
|
2007-12-21 |
2012-08-14 |
Hoffmann-La Roche Inc. |
Bivalent, bispecific antibodies
|
|
PE20091174A1
(es)
|
2007-12-27 |
2009-08-03 |
Chugai Pharmaceutical Co Ltd |
Formulacion liquida con contenido de alta concentracion de anticuerpo
|
|
PT2235064E
(pt)
|
2008-01-07 |
2016-03-01 |
Amgen Inc |
Método de preparação de moléculas heterodiméricas de fc de anticorpos utilizando efeitos de indução eletrostática
|
|
HUE028958T2
(en)
|
2008-02-08 |
2017-01-30 |
Medimmune Llc |
Anti-ifnar1 antibodies with reduced fc ligand affinity
|
|
EP2604280A3
(en)
|
2008-03-27 |
2013-10-16 |
ZymoGenetics, Inc. |
Compositions and methods for inhibiting PDGFRBETA and VEGF-A
|
|
PT2708559T
(pt)
|
2008-04-11 |
2018-05-16 |
Chugai Pharmaceutical Co Ltd |
Molécula de ligação ao antigénio capaz de se ligar repetidamente a duas ou mais moléculas de antigénio
|
|
CN102076355B
(zh)
|
2008-04-29 |
2014-05-07 |
Abbvie公司 |
双重可变结构域免疫球蛋白及其用途
|
|
EP2816059A1
(en)
|
2008-05-01 |
2014-12-24 |
Amgen, Inc |
Anti-hepcidin antibodies and methods of use
|
|
CN102164960A
(zh)
|
2008-09-26 |
2011-08-24 |
罗氏格黎卡特股份公司 |
双特异性抗-egfr/抗-igf-1r抗体
|
|
TWI440469B
(zh)
|
2008-09-26 |
2014-06-11 |
Chugai Pharmaceutical Co Ltd |
Improved antibody molecules
|
|
AR074438A1
(es)
|
2008-12-02 |
2011-01-19 |
Pf Medicament |
Proceso para la modulacion de la actividad antagonista de un anticuerpo monoclonal
|
|
WO2010064090A1
(en)
|
2008-12-02 |
2010-06-10 |
Pierre Fabre Medicament |
Process for the modulation of the antagonistic activity of a monoclonal antibody
|
|
DE202008016028U1
(de)
|
2008-12-04 |
2010-04-15 |
Melitta Haushaltsprodukte Gmbh & Co. Kg |
Behälter zur Aufbewahrung von Gegenständen
|
|
AU2010206681A1
(en)
|
2009-01-23 |
2011-09-01 |
Biogen Idec Ma Inc. |
Stabilized Fc polypeptides with reduced effector function and methods of use
|
|
PE20160653A1
(es)
|
2009-03-05 |
2016-07-24 |
Abbvie Inc |
Proteinas de union a il-17
|
|
JP2010210772A
(ja)
|
2009-03-13 |
2010-09-24 |
Dainippon Screen Mfg Co Ltd |
液晶表示装置の製造方法
|
|
TWI646193B
(zh)
|
2009-03-19 |
2019-01-01 |
中外製藥股份有限公司 |
抗體恆定區域改變體
|
|
WO2010107110A1
(ja)
|
2009-03-19 |
2010-09-23 |
中外製薬株式会社 |
抗体定常領域改変体
|
|
EP2233500A1
(en)
|
2009-03-20 |
2010-09-29 |
LFB Biotechnologies |
Optimized Fc variants
|
|
SG174992A1
(en)
|
2009-04-01 |
2011-11-28 |
Genentech Inc |
Anti-fcrh5 antibodies and immunoconjugates and methods of use
|
|
DK2417156T3
(en)
|
2009-04-07 |
2015-03-02 |
Roche Glycart Ag |
Trivalent, bispecific antibodies
|
|
CN102459346B
(zh)
|
2009-04-27 |
2016-10-26 |
昂考梅德药品有限公司 |
制造异源多聚体分子的方法
|
|
MX368932B
(es)
|
2009-06-26 |
2019-10-22 |
Regeneron Pharma |
Anticuerpos biespecificos facilmente aislados con formato de inmunoglobulina original.
|
|
JP5837821B2
(ja)
|
2009-09-24 |
2015-12-24 |
中外製薬株式会社 |
抗体定常領域改変体
|
|
SI2522724T1
(sl)
|
2009-12-25 |
2020-07-31 |
Chuqai Seiyaku Kabushiki Kaisha |
Postopek za spremembo polipeptida za čiščenje polipetidnih multimerov
|
|
EP2519544A1
(en)
|
2009-12-29 |
2012-11-07 |
Emergent Product Development Seattle, LLC |
Polypeptide heterodimers and uses thereof
|
|
EP2525822B1
(en)
|
2010-01-20 |
2017-05-10 |
Merck Sharp & Dohme Corp. |
Immunoregulation by anti-ilt5 antibodies and ilt5-binding antibody fragments
|
|
TWI505838B
(zh)
|
2010-01-20 |
2015-11-01 |
Chugai Pharmaceutical Co Ltd |
Stabilized antibody solution containing
|
|
CA2787783A1
(en)
|
2010-01-20 |
2011-07-28 |
Tolerx, Inc. |
Anti-ilt5 antibodies and ilt5-binding antibody fragments
|
|
CN102782131B
(zh)
|
2010-03-02 |
2015-08-05 |
协和发酵麒麟株式会社 |
修饰抗体组合物
|
|
EP2543730B1
(en)
|
2010-03-04 |
2018-10-31 |
Chugai Seiyaku Kabushiki Kaisha |
Antibody constant region variant
|
|
CN105218674A
(zh)
|
2010-03-11 |
2016-01-06 |
瑞纳神经科学公司 |
呈pH依赖性抗原结合的抗体
|
|
JP5998050B2
(ja)
|
2010-03-31 |
2016-09-28 |
Jsr株式会社 |
アフィニティークロマトグラフィー用充填剤
|
|
CN110066339A
(zh)
|
2010-04-20 |
2019-07-30 |
根马布股份公司 |
含异二聚体抗体fc的蛋白及其制备方法
|
|
DK2560683T4
(da)
|
2010-04-23 |
2022-08-29 |
Hoffmann La Roche |
Fremstilling af heteromultimeriske proteiner
|
|
EP2569337A1
(en)
|
2010-05-14 |
2013-03-20 |
Rinat Neuroscience Corp. |
Heterodimeric proteins and methods for producing and purifying them
|
|
CA3051311A1
(en)
|
2010-05-27 |
2011-12-01 |
Genmab A/S |
Monoclonal antibodies against her2
|
|
CA2806252C
(en)
|
2010-07-29 |
2019-05-14 |
Xencor, Inc. |
Antibodies with modified isoelectric points
|
|
US20130177555A1
(en)
|
2010-08-13 |
2013-07-11 |
Medimmune Limited |
Monomeric Polypeptides Comprising Variant FC Regions And Methods Of Use
|
|
RU2604490C2
(ru)
|
2010-11-05 |
2016-12-10 |
Займворкс Инк. |
ДИЗАЙН УСТОЙЧИВОГО ГЕТЕРОДИМЕРНОГО АНТИТЕЛА С МУТАЦИЯМИ В Fc ДОМЕНЕ
|
|
TR201802772T4
(tr)
|
2010-11-17 |
2018-03-21 |
Chugai Pharmaceutical Co Ltd |
Kan pıhtılaşma faktörü VIII in işlevi için alternatif işleve sahip multi-spesifik antijen bağlayıcı molekül.
|
|
LT2647707T
(lt)
|
2010-11-30 |
2018-11-12 |
Chugai Seiyaku Kabushiki Kaisha |
Citotoksiškumą indukuojantis terapinis agentas
|
|
US20140112883A1
(en)
|
2011-04-20 |
2014-04-24 |
Liquidating Trust |
Methods for reducing an adverse immune response to a foreign antigen in a human subject with anti-cd4 antibodies or cd4-binding fragments thereof or cd4-binding molecules
|
|
SG11201401422VA
(en)
|
2011-10-27 |
2014-09-26 |
Genmab As |
Production of heterodimeric proteins
|
|
US11851476B2
(en)
|
2011-10-31 |
2023-12-26 |
Chugai Seiyaku Kabushiki Kaisha |
Antigen-binding molecule having regulated conjugation between heavy-chain and light-chain
|
|
KR102052774B1
(ko)
|
2011-11-04 |
2019-12-04 |
자임워크스 인코포레이티드 |
Fc 도메인 내의 돌연변이를 갖는 안정한 이종이합체 항체 설계
|
|
WO2014067011A1
(en)
|
2012-11-02 |
2014-05-08 |
Zymeworks Inc. |
Crystal structures of heterodimeric fc domains
|
|
GB201203051D0
(en)
|
2012-02-22 |
2012-04-04 |
Ucb Pharma Sa |
Biological products
|
|
NZ626955A
(en)
|
2012-03-08 |
2016-01-29 |
Hoffmann La Roche |
Abeta antibody formulation
|
|
AU2013234039B2
(en)
|
2012-03-13 |
2018-02-01 |
Novimmune S.A. |
Readily isolated bispecific antibodies with native immunoglobulin format
|
|
US9751942B2
(en)
|
2012-03-29 |
2017-09-05 |
Chugai Seiyaku Kabushiki Kaisha |
Anti-LAMP5 antibody and utilization thereof
|
|
ES2743399T3
(es)
|
2012-04-20 |
2020-02-19 |
Merus Nv |
Métodos y medios para la producción de moléculas heterodiméricas similares a Ig
|
|
NZ704771A
(en)
|
2012-08-13 |
2018-02-23 |
Regeneron Pharma |
Anti-pcsk9 antibodies with ph-dependent binding characteristics
|
|
JP6273205B2
(ja)
|
2012-10-05 |
2018-01-31 |
協和発酵キリン株式会社 |
ヘテロダイマータンパク質組成物
|
|
MX368665B
(es)
|
2013-03-15 |
2019-10-10 |
Abbvie Biotherapeutics Inc |
Variantes de fc.
|
|
ES2881306T3
(es)
|
2013-09-27 |
2021-11-29 |
Chugai Pharmaceutical Co Ltd |
Método para la producción de heteromultímeros de polipéptidos
|
|
BR112016009919A2
(pt)
|
2013-11-04 |
2017-12-05 |
Glenmark Pharmaceuticals Sa |
imunoglobulina hetero-dimérica ou fragmento da mesma e método para produzir in vitro uma imunoglobulina hetero-dimérica ou fragmento da mesma
|
|
TW201625299A
(zh)
|
2014-06-20 |
2016-07-16 |
Chugai Pharmaceutical Co Ltd |
用於因第viii凝血因子及/或活化的第viii凝血因子的活性降低或欠缺而發病及/或進展的疾病之預防及/或治療之醫藥組成物
|
|
JP6630036B2
(ja)
|
2014-09-30 |
2020-01-15 |
Jsr株式会社 |
標的物の精製方法、及び、ミックスモード用担体
|
|
SG11201706014PA
(en)
|
2015-02-05 |
2017-08-30 |
Chugai Pharmaceutical Co Ltd |
Antibodies comprising an ion concentration dependent antigen-binding domain, fc region variants, il-8-binding antibodies, and uses therof
|
|
WO2016159213A1
(ja)
|
2015-04-01 |
2016-10-06 |
中外製薬株式会社 |
ポリペプチド異種多量体の製造方法
|
|
CN107454906B
(zh)
|
2015-04-17 |
2022-05-27 |
豪夫迈·罗氏有限公司 |
使用凝固因子和多特异性抗体的联合治疗
|
|
JP2018123055A
(ja)
|
2015-04-24 |
2018-08-09 |
公立大学法人奈良県立医科大学 |
血液凝固第viii因子(fviii)の機能を代替する多重特異性抗原結合分子を含有する、血液凝固第xi因子(fxi)異常症の予防および/または治療に用いられる医薬組成物
|
|
JP7219005B2
(ja)
|
2015-12-28 |
2023-02-07 |
中外製薬株式会社 |
Fc領域含有ポリペプチドの精製を効率化するための方法
|
|
JP7320943B2
(ja)
|
2016-04-28 |
2023-08-04 |
中外製薬株式会社 |
抗体含有製剤
|
|
TW201836636A
(zh)
|
2017-03-31 |
2018-10-16 |
公立大學法人奈良縣立醫科大學 |
含有替代凝血因子viii功能之多特異性抗原結合分子之用於預防和/或治療凝血因子ix異常症的醫藥組合物
|