GB2400851B - Identifying binding of a polypeptide to a polypeptide target - Google Patents

Identifying binding of a polypeptide to a polypeptide target

Info

Publication number
GB2400851B
GB2400851B GB0309397A GB0309397A GB2400851B GB 2400851 B GB2400851 B GB 2400851B GB 0309397 A GB0309397 A GB 0309397A GB 0309397 A GB0309397 A GB 0309397A GB 2400851 B GB2400851 B GB 2400851B
Authority
GB
United Kingdom
Prior art keywords
polypeptide
target
identifying binding
identifying
binding
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
GB0309397A
Other versions
GB0309397D0 (en
GB2400851A (en
Inventor
Mats Ohlin
Helena Persson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bioinvent International AB
Original Assignee
Bioinvent International AB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bioinvent International AB filed Critical Bioinvent International AB
Priority to GB0309397A priority Critical patent/GB2400851B/en
Publication of GB0309397D0 publication Critical patent/GB0309397D0/en
Priority to PCT/EP2004/004387 priority patent/WO2004097041A2/en
Publication of GB2400851A publication Critical patent/GB2400851A/en
Application granted granted Critical
Publication of GB2400851B publication Critical patent/GB2400851B/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/005—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies constructed by phage libraries
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/44—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material not provided for elsewhere, e.g. haptens, metals, DNA, RNA, amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
GB0309397A 2003-04-25 2003-04-25 Identifying binding of a polypeptide to a polypeptide target Expired - Fee Related GB2400851B (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
GB0309397A GB2400851B (en) 2003-04-25 2003-04-25 Identifying binding of a polypeptide to a polypeptide target
PCT/EP2004/004387 WO2004097041A2 (en) 2003-04-25 2004-04-23 Screening method for binding molecules

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB0309397A GB2400851B (en) 2003-04-25 2003-04-25 Identifying binding of a polypeptide to a polypeptide target

Publications (3)

Publication Number Publication Date
GB0309397D0 GB0309397D0 (en) 2003-06-04
GB2400851A GB2400851A (en) 2004-10-27
GB2400851B true GB2400851B (en) 2004-12-15

Family

ID=9957209

Family Applications (1)

Application Number Title Priority Date Filing Date
GB0309397A Expired - Fee Related GB2400851B (en) 2003-04-25 2003-04-25 Identifying binding of a polypeptide to a polypeptide target

Country Status (2)

Country Link
GB (1) GB2400851B (en)
WO (1) WO2004097041A2 (en)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7601351B1 (en) 2002-06-26 2009-10-13 Human Genome Sciences, Inc. Antibodies against protective antigen
CA2490280A1 (en) 2002-07-01 2004-01-08 Human Genome Sciences, Inc. Antibodies that specifically bind to reg iv
TWI671403B (en) 2005-03-31 2019-09-11 中外製藥股份有限公司 Method for controlling controlled assembly of polypeptide
DK2824183T3 (en) * 2005-04-08 2020-09-28 Chugai Pharmaceutical Co Ltd Process for the production of bispecific antibodies
EP3056568B1 (en) 2006-03-31 2021-09-15 Chugai Seiyaku Kabushiki Kaisha Methods for controlling blood pharmacokinetics of antibodies
JP5144499B2 (en) 2006-03-31 2013-02-13 中外製薬株式会社 Antibody modification method for purifying bispecific antibodies
ES2595638T3 (en) 2007-09-26 2017-01-02 Chugai Seiyaku Kabushiki Kaisha Method to modify the isoelectric point of an antibody by replacing amino acids in a CDR
WO2011123857A1 (en) * 2010-04-02 2011-10-06 Kalobios Pharmaceuticals, Inc. Generation of antibodies to an epitope of interest
TW201631153A (en) 2010-11-17 2016-09-01 中外製藥股份有限公司 Multi-specific antigen-binding molecule having alternative function to function of blood coagulation factor viii
EP3050896B1 (en) 2013-09-27 2021-07-07 Chugai Seiyaku Kabushiki Kaisha Method for producing polypeptide heteromultimer
TWI701435B (en) 2014-09-26 2020-08-11 日商中外製藥股份有限公司 Method to determine the reactivity of FVIII
TWI700300B (en) 2014-09-26 2020-08-01 日商中外製藥股份有限公司 Antibodies that neutralize substances with the function of FVIII coagulation factor (FVIII)
MA40764A (en) 2014-09-26 2017-08-01 Chugai Pharmaceutical Co Ltd THERAPEUTIC AGENT INDUCING CYTOTOXICITY
WO2016159213A1 (en) 2015-04-01 2016-10-06 中外製薬株式会社 Method for producing polypeptide hetero-oligomer
AU2016381992B2 (en) 2015-12-28 2024-01-04 Chugai Seiyaku Kabushiki Kaisha Method for promoting efficiency of purification of Fc region-containing polypeptide
MX2019002510A (en) 2016-09-06 2019-06-24 Chugai Pharmaceutical Co Ltd Methods of using a bispecific antibody that recognizes coagulation factor ix and/or activated coagulation factor ix and coagulation factor x and/or activated coagulation factor x.
KR20200049764A (en) 2017-09-29 2020-05-08 추가이 세이야쿠 가부시키가이샤 Multispecific antigen-binding molecules having blood coagulation factor viii (fviii) cofactor function-substituting activity and pharmaceutical formulations containing such a molecule as an active ingredient

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4778751A (en) * 1986-05-12 1988-10-18 Diagnostic Products Corporation Method for measuring antigens or antibodies in biological fluids using ligand labeled antigens or ligand labeled antibodies
WO2002068691A1 (en) * 2001-02-22 2002-09-06 Isis Pharmaceuticals, Inc. Methods for identifying ligand binding sites in a biomolecule

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE9304060D0 (en) * 1993-12-06 1993-12-06 Bioinvent Int Ab Methods to select specific bacteriophages
GB0008419D0 (en) * 2000-04-05 2000-05-24 Bioinvent Int Ab A method for invitro molecular evolution of antibody function

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4778751A (en) * 1986-05-12 1988-10-18 Diagnostic Products Corporation Method for measuring antigens or antibodies in biological fluids using ligand labeled antigens or ligand labeled antibodies
WO2002068691A1 (en) * 2001-02-22 2002-09-06 Isis Pharmaceuticals, Inc. Methods for identifying ligand binding sites in a biomolecule

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Nucl Acids Res; Vol 31, pp e23 (2003). Tanaka et al. "De novo production of diverse intracellular antibody libraries *

Also Published As

Publication number Publication date
WO2004097041A3 (en) 2005-02-03
WO2004097041A2 (en) 2004-11-11
GB0309397D0 (en) 2003-06-04
GB2400851A (en) 2004-10-27

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Legal Events

Date Code Title Description
PCNP Patent ceased through non-payment of renewal fee

Effective date: 20070425