DK2825559T3 - Letisolerbare bispecifikke antistoffer med nativt immunoglobulinformat - Google Patents
Letisolerbare bispecifikke antistoffer med nativt immunoglobulinformat Download PDFInfo
- Publication number
- DK2825559T3 DK2825559T3 DK13739281.7T DK13739281T DK2825559T3 DK 2825559 T3 DK2825559 T3 DK 2825559T3 DK 13739281 T DK13739281 T DK 13739281T DK 2825559 T3 DK2825559 T3 DK 2825559T3
- Authority
- DK
- Denmark
- Prior art keywords
- liquidable
- information
- bispecific antibodies
- native immunoglobulin
- immunoglobulin
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/46—Hybrid immunoglobulins
- C07K16/468—Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
- C07K16/244—Interleukins [IL]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2809—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Life Sciences & Earth Sciences (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261610141P | 2012-03-13 | 2012-03-13 | |
| PCT/IB2013/000902 WO2013136186A2 (en) | 2012-03-13 | 2013-03-13 | Readily isolated bispecific antibodies with native immunoglobulin format |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK2825559T3 true DK2825559T3 (da) | 2019-06-03 |
Family
ID=48803578
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK13739281.7T DK2825559T3 (da) | 2012-03-13 | 2013-03-13 | Letisolerbare bispecifikke antistoffer med nativt immunoglobulinformat |
Country Status (9)
| Country | Link |
|---|---|
| US (3) | US9815909B2 (da) |
| EP (2) | EP2825559B1 (da) |
| JP (3) | JP6273219B2 (da) |
| AU (2) | AU2013234039B2 (da) |
| CA (1) | CA2867020C (da) |
| DK (1) | DK2825559T3 (da) |
| ES (1) | ES2728301T3 (da) |
| PT (1) | PT2825559T (da) |
| WO (1) | WO2013136186A2 (da) |
Families Citing this family (61)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI671403B (zh) | 2005-03-31 | 2019-09-11 | 中外製藥股份有限公司 | 控制組裝之多肽的製造方法 |
| WO2007114325A1 (ja) | 2006-03-31 | 2007-10-11 | Chugai Seiyaku Kabushiki Kaisha | 二重特異性抗体を精製するための抗体改変方法 |
| IN2014DN10515A (da) | 2006-03-31 | 2015-08-21 | Chugai Pharmaceutical Co Ltd | |
| MX336725B (es) | 2007-09-26 | 2016-01-28 | Chugai Pharmaceutical Co Ltd | Metodo de modificacion del punto isoelectrico de anticuerpos medinate la sustitucion de aminoacidos en region de determinacion de complementariedad (cdr). |
| DK3059246T3 (da) | 2007-09-26 | 2018-10-01 | Chugai Pharmaceutical Co Ltd | Modificeret konstant region i et antistof |
| EP2543730B1 (en) | 2010-03-04 | 2018-10-31 | Chugai Seiyaku Kabushiki Kaisha | Antibody constant region variant |
| JP6013915B2 (ja) | 2010-11-17 | 2016-10-25 | 中外製薬株式会社 | 血液凝固第ｖｉｉｉ因子の機能を代替する機能を有する多重特異性抗原結合分子 |
| PT3434767T (pt) | 2010-11-30 | 2026-01-23 | Chugai Pharmaceutical Co Ltd | Agente terapêutico indutor de citotoxicidade |
| EP2900696A1 (en) | 2012-09-25 | 2015-08-05 | Glenmark Pharmaceuticals S.A. | Purification of hetero-dimeric immunoglobulins |
| CA2922979A1 (en) * | 2013-09-03 | 2015-03-12 | Novimmune S.A. | Readily isolated bispecific binding molecules with native format having mutated constant regions |
| SG10201803449VA (en) | 2013-09-27 | 2018-05-30 | Chugai Pharmaceutical Co Ltd | Method for producing polypeptide heteromultimer |
| GB201411420D0 (en) * | 2014-06-26 | 2014-08-13 | Ucb Biopharma Sprl | Antibody constructs |
| AR101262A1 (es) | 2014-07-26 | 2016-12-07 | Regeneron Pharma | Plataforma de purificación para anticuerpos biespecíficos |
| GB201414823D0 (en) | 2014-08-20 | 2014-10-01 | Argen X Bv | Multispecific antibodies |
| JP7082484B2 (ja) | 2015-04-01 | 2022-06-08 | 中外製薬株式会社 | ポリペプチド異種多量体の製造方法 |
| AU2016245887B2 (en) | 2015-04-10 | 2021-09-23 | Adimab, Llc. | Methods for purifying heterodimeric multispecific antibodies from parental homodimeric antibody species |
| JP7240812B2 (ja) * | 2015-05-12 | 2023-03-16 | リジェネロン・ファーマシューティカルズ・インコーポレイテッド | 多量体タンパク質の純度の決定 |
| US20180201693A1 (en) | 2015-07-09 | 2018-07-19 | Genmab A/S | Bispecific and multispecific antibodies and method for isolation of such |
| CA3004288C (en) * | 2015-12-28 | 2025-05-27 | Chugai Seiyaku Kabushiki Kaisha | METHOD FOR PROMOTING THE CLEARANCE EFFICIENCY OF A POLYPEPTIDE CONTAINING THE FC REGION |
| CA3016563A1 (en) | 2016-03-21 | 2017-09-28 | Elstar Therapeutics, Inc. | Multispecific and multifunctional molecules and uses thereof |
| AU2017255077B2 (en) | 2016-04-28 | 2024-05-16 | Chugai Seiyaku Kabushiki Kaisha | Antibody-containing preparation |
| US20200291089A1 (en) | 2017-02-16 | 2020-09-17 | Elstar Therapeutics, Inc. | Multifunctional molecules comprising a trimeric ligand and uses thereof |
| WO2018212556A1 (en) * | 2017-05-16 | 2018-11-22 | Cj Healthcare Corporation | A method for purifying an antibody or an antibody fragment thereof using affinity chromatography |
| WO2018222901A1 (en) | 2017-05-31 | 2018-12-06 | Elstar Therapeutics, Inc. | Multispecific molecules that bind to myeloproliferative leukemia (mpl) protein and uses thereof |
| CN110785185B (zh) * | 2017-06-05 | 2024-05-24 | 詹森生物科技公司 | 具有非对称ch2-ch3区突变的工程化多特异性抗体和其他多聚体蛋白 |
| WO2019035938A1 (en) | 2017-08-16 | 2019-02-21 | Elstar Therapeutics, Inc. | MULTISPECIFIC MOLECULES BINDING TO BCMA AND USES THEREOF |
| BR112020008393A2 (pt) | 2017-11-01 | 2020-11-03 | Chugai Seiyaku Kabushiki Kaisha | variante e isoforma de anticorpos com atividade biológica reduzida |
| CN111344306A (zh) * | 2017-11-02 | 2020-06-26 | 拜耳股份公司 | 结合alk-1和bmpr-2的双特异性抗体 |
| EP4495142A3 (en) | 2017-12-22 | 2025-05-07 | Argenx BVBA | Bispecific antigen binding construct |
| US12247060B2 (en) | 2018-01-09 | 2025-03-11 | Marengo Therapeutics, Inc. | Calreticulin binding constructs and engineered T cells for the treatment of diseases |
| GB201802487D0 (en) | 2018-02-15 | 2018-04-04 | Argenx Bvba | Cytokine combination therapy |
| WO2019178362A1 (en) | 2018-03-14 | 2019-09-19 | Elstar Therapeutics, Inc. | Multifunctional molecules that bind to calreticulin and uses thereof |
| WO2019178364A2 (en) | 2018-03-14 | 2019-09-19 | Elstar Therapeutics, Inc. | Multifunctional molecules and uses thereof |
| CA3104390A1 (en) * | 2018-06-22 | 2019-12-26 | Genmab A/S | Method for producing a controlled mixture of two or more different antibodies |
| CA3105448A1 (en) | 2018-07-03 | 2020-01-09 | Elstar Therapeutics, Inc. | Anti-tcr antibody molecules and uses thereof |
| BR112021004680A2 (pt) * | 2018-09-21 | 2021-08-31 | Teneobio, Inc. | Métodos para purificar anticorpos multiespecíficos heterodiméricos |
| TWI874341B (zh) | 2018-12-18 | 2025-03-01 | 美商健生生物科技公司 | 產生異二聚體抗體之方法 |
| BR112021012337A2 (pt) | 2018-12-24 | 2021-09-14 | Sanofi | Proteínas de ligação multiespecíficas baseadas em pseudofab |
| EP3927431A1 (en) | 2019-02-21 | 2021-12-29 | Marengo Therapeutics, Inc. | Anti-tcr antibody molecules and uses thereof |
| CN114127112A (zh) | 2019-02-21 | 2022-03-01 | 马伦戈治疗公司 | 与t细胞结合的多功能分子及其治疗自身免疫性病症的用途 |
| EP3927746A1 (en) | 2019-02-21 | 2021-12-29 | Marengo Therapeutics, Inc. | Multifunctional molecules that bind to calreticulin and uses thereof |
| GB2597851B (en) | 2019-02-21 | 2024-05-29 | Marengo Therapeutics Inc | Antibody molecules that bind to NKP30 and uses thereof |
| EP3927744A1 (en) | 2019-02-21 | 2021-12-29 | Marengo Therapeutics, Inc. | Multifunctional molecules that bind to t cell related cancer cells and uses thereof |
| WO2021138407A2 (en) | 2020-01-03 | 2021-07-08 | Marengo Therapeutics, Inc. | Multifunctional molecules that bind to cd33 and uses thereof |
| EP4084823A4 (en) | 2020-01-03 | 2024-05-15 | Marengo Therapeutics, Inc. | ANTI-TCR ANTIBODY MOLECULES AND THEIR USES |
| CA3173162A1 (en) | 2020-03-25 | 2021-09-30 | Eli Lilly And Company | Multispecific binding proteins and methods of developing the same |
| CA3180321A1 (en) | 2020-04-24 | 2021-10-28 | Marengo Therapeutics, Inc. | Multifunctional molecules that bind to t cell related cancer cells and uses thereof |
| WO2022046920A2 (en) | 2020-08-26 | 2022-03-03 | Marengo Therapeutics, Inc. | Multifunctional molecules that bind to calreticulin and uses thereof |
| GB2616128A (en) | 2020-08-26 | 2023-08-30 | Marengo Therapeutics Inc | Antibody molecules that bind to NKp30 and uses thereof |
| JP2023540248A (ja) | 2020-08-26 | 2023-09-22 | マレンゴ・セラピューティクス，インコーポレーテッド | Ｔｒｂｃ１またはｔｒｂｃ２を検出する方法 |
| KR20240004462A (ko) | 2021-04-08 | 2024-01-11 | 마렝고 테라퓨틱스, 인크. | Tcr에 결합하는 다기능성 분자 및 이의 용도 |
| EP4604988A1 (en) | 2022-10-21 | 2025-08-27 | Diagonal Therapeutics Inc. | Heteromeric agonistic antibodies to il-18 receptor |
| AU2024254039A1 (en) | 2023-04-07 | 2025-10-02 | Diagonal Therapeutics Inc. | Hinge-modified bispecific antibodies |
| KR20250168499A (ko) | 2023-04-07 | 2025-12-02 | 다이애고널 테라퓨틱스 인코포레이티드 | 액티빈 a 수용체 유사 유형 1(alk1)에 대한 이중 특이적 효현성 항체 |
| AU2024276812A1 (en) | 2023-05-19 | 2025-11-06 | Diagonal Therapeutics Inc. | Bispecific agonistic antibodies to il12 receptor |
| WO2025090519A1 (en) | 2023-10-23 | 2025-05-01 | Diagonal Therapeutics Inc. | Heteromeric agonistic antibodies to il-18 receptor |
| WO2025213061A2 (en) | 2024-04-04 | 2025-10-09 | Ethyreal Bio, Inc. | Anti-tshr antibodies and uses thereof |
| WO2026011013A1 (en) | 2024-07-02 | 2026-01-08 | Epibiologics, Inc. | Binding agents and uses thereof |
| WO2026037839A2 (en) | 2024-08-12 | 2026-02-19 | ONA Therapeutics S.L. | Anti-fgfr4 molecules and uses thereof |
| WO2026044000A1 (en) | 2024-08-20 | 2026-02-26 | Ethyreal Bio, Inc. | Multispecific antibodies and methods of use thereof |
| WO2026050572A2 (en) | 2024-08-29 | 2026-03-05 | Marengo Therapeutics, Inc. | Multifunctional molecules binding to tcr and uses thereof |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20020062010A1 (en) | 1997-05-02 | 2002-05-23 | Genentech, Inc. | Method for making multispecific antibodies having heteromultimeric and common components |
| ES2637801T3 (es) | 2000-04-11 | 2017-10-17 | Genentech, Inc. | Anticuerpos multivalentes y usos de los mismos |
| EP4353819A3 (en) | 2004-07-22 | 2024-07-17 | Erasmus University Medical Center Rotterdam | Binding molecules |
| EP2035456A1 (en) | 2006-06-22 | 2009-03-18 | Novo Nordisk A/S | Production of bispecific antibodies |
| EP2143345A1 (en) * | 2008-07-09 | 2010-01-13 | Reemtsma Cigarettenfabriken GmbH | Cigarette paper |
| KR101747103B1 (ko) | 2009-06-26 | 2017-06-14 | 리제너론 파마슈티칼스 인코포레이티드 | 천연 면역글로불린 포맷을 가지는 용이하게 분리된 이중특이성 항체 |
-
2013
- 2013-03-13 EP EP13739281.7A patent/EP2825559B1/en active Active
- 2013-03-13 ES ES13739281T patent/ES2728301T3/es active Active
- 2013-03-13 JP JP2014561539A patent/JP6273219B2/ja active Active
- 2013-03-13 EP EP19159351.6A patent/EP3517548A1/en not_active Withdrawn
- 2013-03-13 US US13/798,485 patent/US9815909B2/en active Active
- 2013-03-13 PT PT13739281T patent/PT2825559T/pt unknown
- 2013-03-13 CA CA2867020A patent/CA2867020C/en active Active
- 2013-03-13 DK DK13739281.7T patent/DK2825559T3/da active
- 2013-03-13 WO PCT/IB2013/000902 patent/WO2013136186A2/en not_active Ceased
- 2013-03-13 AU AU2013234039A patent/AU2013234039B2/en active Active
-
2017
- 2017-11-13 US US15/811,126 patent/US10494446B2/en active Active
- 2017-12-22 AU AU2017279804A patent/AU2017279804B2/en active Active
-
2018
- 2018-01-05 JP JP2018000542A patent/JP2018083829A/ja active Pending
-
2019
- 2019-11-27 US US16/698,248 patent/US20200231707A1/en not_active Abandoned
-
2021
- 2021-02-26 JP JP2021029357A patent/JP2021091701A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| JP2015510764A (ja) | 2015-04-13 |
| EP2825559A2 (en) | 2015-01-21 |
| JP6273219B2 (ja) | 2018-01-31 |
| JP2018083829A (ja) | 2018-05-31 |
| AU2013234039A1 (en) | 2014-09-25 |
| JP2021091701A (ja) | 2021-06-17 |
| ES2728301T3 (es) | 2019-10-23 |
| CA2867020C (en) | 2022-11-15 |
| WO2013136186A3 (en) | 2014-01-23 |
| US9815909B2 (en) | 2017-11-14 |
| CA2867020A1 (en) | 2013-09-19 |
| US20180057611A1 (en) | 2018-03-01 |
| AU2017279804A1 (en) | 2018-01-25 |
| AU2013234039B2 (en) | 2018-02-01 |
| EP2825559B1 (en) | 2019-02-27 |
| WO2013136186A2 (en) | 2013-09-19 |
| EP3517548A1 (en) | 2019-07-31 |
| US20200231707A1 (en) | 2020-07-23 |
| US20140051833A1 (en) | 2014-02-20 |
| AU2017279804B2 (en) | 2020-03-12 |
| US10494446B2 (en) | 2019-12-03 |
| PT2825559T (pt) | 2019-06-07 |
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