MX363213B - Anticuerpos anti-pcsk9 con características de unión dependientes del ph. - Google Patents

Anticuerpos anti-pcsk9 con características de unión dependientes del ph.

Info

Publication number
MX363213B
MX363213B MX2015001907A MX2015001907A MX363213B MX 363213 B MX363213 B MX 363213B MX 2015001907 A MX2015001907 A MX 2015001907A MX 2015001907 A MX2015001907 A MX 2015001907A MX 363213 B MX363213 B MX 363213B
Authority
MX
Mexico
Prior art keywords
antibodies
dependent binding
exhibit
binding properties
pcsk9
Prior art date
Application number
MX2015001907A
Other languages
English (en)
Other versions
MX2015001907A (es
Inventor
J Murphy Andrew
D Yancopoulos George
J Papadopoulos Nicholas
Stahl Neil
Original Assignee
Regeneron Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Regeneron Pharma filed Critical Regeneron Pharma
Publication of MX2015001907A publication Critical patent/MX2015001907A/es
Publication of MX363213B publication Critical patent/MX363213B/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Obesity (AREA)
  • General Chemical & Material Sciences (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

La presente invención se refiere a anticuerpos y fragmentos de unión a antígeno de los mismos que específicamente se unen a proproteína convertasa subtilisina/kexina tipo 9 (PCSK9) con mayor afinidad a pH neutro que a pH ácido. Los anticuerpos de la invención pueden poseer uno o más cambios de aminoácidos en comparación con los anticuerpos que no presentan propiedades de unión dependientes del pH. Por ejemplo, la presente invención incluye anticuerpos anti-PCSK9 que poseen una o más sustituciones de histidina en una o más regiones determinantes de la complementariedad. Los anticuerpos de la invención, con propiedades de unión dependientes del pH, permanecen en la circulación y exhiben actividad reductora del colesterol en sujetos animales durante períodos de tiempo prolongados en comparación con los anticuerpos anti-PCSK9 que no presentan propiedades de unión dependientes del pH. Por lo tanto, los anticuerpos de la invención son útiles para el tratamiento de enfermedades y trastornos relacionados con concentraciones elevadas de colesterol HDL, por lo que los anticuerpos de la invención se pueden administrar a un paciente en dosis más bajas y/o con menos frecuencia en comparación con los anticuerpos que no exhiben propiedades de unión dependientes del pH.
MX2015001907A 2012-08-13 2013-08-12 Anticuerpos anti-pcsk9 con características de unión dependientes del ph. MX363213B (es)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US201261682349P 2012-08-13 2012-08-13
US201261703342P 2012-09-20 2012-09-20
US201261734398P 2012-12-07 2012-12-07
US201361761383P 2013-02-06 2013-02-06
US201361828258P 2013-05-29 2013-05-29
PCT/US2013/054456 WO2014028354A1 (en) 2012-08-13 2013-08-12 Anti-pcsk9 antibodies with ph-dependent binding characteristics

Publications (2)

Publication Number Publication Date
MX2015001907A MX2015001907A (es) 2015-06-05
MX363213B true MX363213B (es) 2019-03-15

Family

ID=50066319

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2015001907A MX363213B (es) 2012-08-13 2013-08-12 Anticuerpos anti-pcsk9 con características de unión dependientes del ph.

Country Status (16)

Country Link
US (1) US9540449B2 (es)
EP (1) EP2882778B1 (es)
JP (1) JP6309521B2 (es)
KR (1) KR20150041662A (es)
CN (1) CN104540852B (es)
AR (1) AR092098A1 (es)
AU (1) AU2013302925B2 (es)
CA (1) CA2881679C (es)
EA (1) EA028244B1 (es)
HK (1) HK1211603A1 (es)
IL (1) IL236785B (es)
MX (1) MX363213B (es)
NZ (1) NZ704771A (es)
TW (1) TWI596115B (es)
UY (1) UY34975A (es)
WO (1) WO2014028354A1 (es)

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