EA201592304A1 - Способы лечения аутосомно-доминантой гиперхолестеринемии, ассоциированной с мутацией приобретения функции гена pcsk9 - Google Patents

Способы лечения аутосомно-доминантой гиперхолестеринемии, ассоциированной с мутацией приобретения функции гена pcsk9

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EA201592304A1
EA201592304A1 EA201592304A EA201592304A EA201592304A1 EA 201592304 A1 EA201592304 A1 EA 201592304A1 EA 201592304 A EA201592304 A EA 201592304A EA 201592304 A EA201592304 A EA 201592304A EA 201592304 A1 EA201592304 A1 EA 201592304A1
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pcsk9
methods
mutation
present
hypersholesterynemia
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EA201592304A
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English (en)
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Гари Сверголд
Скотт Меллис
Уилльям Дж. Сасьела
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Ридженерон Фармасьютикалз, Инк.
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Publication of EA201592304A1 publication Critical patent/EA201592304A1/ru

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    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
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Abstract

Настоящее изобретение предлагает способы лечения аутосомно-доминантной гиперхолестеринемии (АДГ). Согласно некоторым вариантам осуществления настоящего изобретения АДГ вызывается или ассоциирована с мутацией приобретения функции (МПФ) гена, кодирующего фермент PCSK9. Таким образом, настоящее изобретение включает способы, предполагающие отбор пациента с МПФ в одном или обоих аллелях гена PCSK9 и введение пациенту фармацевтической композиции, содержащей ингибитор фермента PCSK9. Согласно некоторым вариантам осуществления настоящего изобретения ингибитор фермента PCSK9 представляет собой антитело к PCSK9, примером которого в этом документе является mAb316Р.
EA201592304A 2013-05-30 2014-05-29 Способы лечения аутосомно-доминантой гиперхолестеринемии, ассоциированной с мутацией приобретения функции гена pcsk9 EA201592304A1 (ru)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201361828730P 2013-05-30 2013-05-30
US201361889553P 2013-10-11 2013-10-11
US201361901212P 2013-11-07 2013-11-07
PCT/US2014/040050 WO2014194111A1 (en) 2013-05-30 2014-05-29 Methods for treating autosomal dominant hypercholesterolemia associated with pcsk9 gain-of-function mutations

Publications (1)

Publication Number Publication Date
EA201592304A1 true EA201592304A1 (ru) 2016-04-29

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Country Status (13)

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US (2) US20140356370A1 (ru)
EP (1) EP3004172B1 (ru)
JP (1) JP6423868B2 (ru)
KR (1) KR20160013046A (ru)
CN (2) CN113144195A (ru)
AU (1) AU2014274077B2 (ru)
CA (1) CA2912101A1 (ru)
EA (1) EA201592304A1 (ru)
HK (1) HK1216896A1 (ru)
IL (1) IL242251B (ru)
TW (1) TWI682780B (ru)
WO (1) WO2014194111A1 (ru)
ZA (1) ZA201507798B (ru)

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HK1216896A1 (zh) 2016-12-09
ZA201507798B (en) 2017-04-26
AU2014274077A1 (en) 2015-11-19
CA2912101A1 (en) 2014-12-04
US20190330371A1 (en) 2019-10-31
IL242251B (en) 2020-02-27
KR20160013046A (ko) 2016-02-03
JP6423868B2 (ja) 2018-11-14
JP2016522211A (ja) 2016-07-28
CN105263963A (zh) 2016-01-20
AU2014274077B2 (en) 2019-09-26
EP3004172B1 (en) 2019-11-27
WO2014194111A1 (en) 2014-12-04
CN105263963B (zh) 2021-03-05
EP3004172A1 (en) 2016-04-13
TW201536315A (zh) 2015-10-01
US20140356370A1 (en) 2014-12-04
TWI682780B (zh) 2020-01-21
CN113144195A (zh) 2021-07-23

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