JP2009545319A5 - - Google Patents

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Publication number
JP2009545319A5
JP2009545319A5 JP2009522880A JP2009522880A JP2009545319A5 JP 2009545319 A5 JP2009545319 A5 JP 2009545319A5 JP 2009522880 A JP2009522880 A JP 2009522880A JP 2009522880 A JP2009522880 A JP 2009522880A JP 2009545319 A5 JP2009545319 A5 JP 2009545319A5
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JP
Japan
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seq
amino acid
acid sequence
antibody
group
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
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JP2009522880A
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English (en)
Japanese (ja)
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JP2009545319A (ja
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Priority claimed from PCT/US2007/017337 external-priority patent/WO2008019061A2/en
Publication of JP2009545319A publication Critical patent/JP2009545319A/ja
Publication of JP2009545319A5 publication Critical patent/JP2009545319A5/ja
Pending legal-status Critical Current

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JP2009522880A 2006-08-03 2007-08-03 抗ｉｌ−６モノクローナル抗体およびその使用 Pending JP2009545319A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US83510706P 2006-08-03 2006-08-03
PCT/US2007/017337 WO2008019061A2 (en) 2006-08-03 2007-08-03 Anti-il-6 monoclonal antibodies and uses thereof

Publications (2)

Publication Number Publication Date
JP2009545319A JP2009545319A (ja) 2009-12-24
JP2009545319A5 true JP2009545319A5 (enExample) 2010-10-14

Family

ID=39033490

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2009522880A Pending JP2009545319A (ja) 2006-08-03 2007-08-03 抗ｉｌ−６モノクローナル抗体およびその使用

Country Status (17)

Country Link
US (1) US7919095B2 (enExample)
EP (1) EP2064241B1 (enExample)
JP (1) JP2009545319A (enExample)
KR (1) KR101479537B1 (enExample)
CN (1) CN101563365B (enExample)
AU (1) AU2007282023B2 (enExample)
BR (1) BRPI0715115A2 (enExample)
CA (1) CA2657763C (enExample)
CO (1) CO6150192A2 (enExample)
CR (1) CR10563A (enExample)
EA (1) EA200900037A1 (enExample)
IL (1) IL196550A0 (enExample)
MA (1) MA30653B1 (enExample)
MX (1) MX2009001110A (enExample)
NO (1) NO20090224L (enExample)
WO (1) WO2008019061A2 (enExample)
ZA (1) ZA200900514B (enExample)

Families Citing this family (45)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW200831528A (en) 2006-11-30 2008-08-01 Astrazeneca Ab Compounds
US8178101B2 (en) 2007-05-21 2012-05-15 Alderbio Holdings Inc. Use of anti-IL-6 antibodies having specific binding properties to treat cachexia
US8062864B2 (en) 2007-05-21 2011-11-22 Alderbio Holdings Llc Nucleic acids encoding antibodies to IL-6, and recombinant production of anti-IL-6 antibodies
TWI617576B (zh) 2007-05-21 2018-03-11 艾爾德生物控股有限責任公司 介白素-６（ｉｌ-６）的抗體及其等之用途
US8252286B2 (en) 2007-05-21 2012-08-28 Alderbio Holdings Llc Antagonists of IL-6 to prevent or treat thrombosis
US7906117B2 (en) 2007-05-21 2011-03-15 Alderbio Holdings Llc Antagonists of IL-6 to prevent or treat cachexia, weakness, fatigue, and/or fever
US8404235B2 (en) 2007-05-21 2013-03-26 Alderbio Holdings Llc Antagonists of IL-6 to raise albumin and/or lower CRP
US20090238825A1 (en) * 2007-05-21 2009-09-24 Kovacevich Brian R Novel rabbit antibody humanization methods and humanized rabbit antibodies
US9701747B2 (en) 2007-05-21 2017-07-11 Alderbio Holdings Llc Method of improving patient survivability and quality of life by anti-IL-6 antibody administration
CN102089326B (zh) 2008-05-13 2014-12-31 诺维莫尼公司 抗白细胞介素-6/白细胞介素-6受体的抗体及其使用方法
US8188235B2 (en) 2008-06-18 2012-05-29 Pfizer Inc. Antibodies to IL-6 and their uses
CA2737351A1 (en) * 2008-09-26 2010-04-01 Wyeth Llc Single chain antibody library design
CA2742786A1 (en) * 2008-11-13 2010-05-20 Femta Pharmaceuticals, Inc. Humanized anti-il-6 antibodies
CN102292449B (zh) * 2008-11-25 2016-03-30 奥尔德生物制药公司 预防或治疗血栓形成的il-6拮抗剂
US8323649B2 (en) 2008-11-25 2012-12-04 Alderbio Holdings Llc Antibodies to IL-6 and use thereof
US8992920B2 (en) 2008-11-25 2015-03-31 Alderbio Holdings Llc Anti-IL-6 antibodies for the treatment of arthritis
US9452227B2 (en) 2008-11-25 2016-09-27 Alderbio Holdings Llc Methods of treating or diagnosing conditions associated with elevated IL-6 using anti-IL-6 antibodies or fragments
US8337847B2 (en) 2008-11-25 2012-12-25 Alderbio Holdings Llc Methods of treating anemia using anti-IL-6 antibodies
US9212223B2 (en) 2008-11-25 2015-12-15 Alderbio Holdings Llc Antagonists of IL-6 to prevent or treat thrombosis
US8420089B2 (en) 2008-11-25 2013-04-16 Alderbio Holdings Llc Antagonists of IL-6 to raise albumin and/or lower CRP
JP5913103B2 (ja) 2009-09-14 2016-04-27 ザ リージェンツ オブ ザ ユニバーシティ オブ コロラド，ア ボディー コーポレイトＴＨＥ ＲＥＧＥＮＴＳ ＯＦ ＴＨＥ ＵＮＩＶＥＲＳＩＴＹ ＯＦ ＣＯＬＯＲＡＤＯ，ａ ｂｏｄｙ ｃｏｒｐｏｒａｔｅ 酵母ベースの免疫療法組成物を含む組合せ物及び被験者のスクリーニング方法
US9775921B2 (en) 2009-11-24 2017-10-03 Alderbio Holdings Llc Subcutaneously administrable composition containing anti-IL-6 antibody
EP2504030A4 (en) 2009-11-24 2013-06-26 Alderbio Holdings Llc IL-6 ANTAGONISTS FOR INCREASING ALBUMIN AND / OR REDUCING CRP
MY177062A (en) 2010-03-12 2020-09-03 Debiopharm Int Sa Cd37-binding molecules and immunoconjugates thereof
EP2643016A2 (en) 2010-11-23 2013-10-02 Alder Biopharmaceuticals, Inc. Anti-il-6 antibodies for the treatment of anemia
US20120189621A1 (en) 2011-01-21 2012-07-26 Yann Dean Combination Therapies and Methods Using Anti-CD3 Modulating Agents and Anti-IL-6 Antagonists
EA201391342A1 (ru) * 2011-04-01 2014-11-28 Иммьюноджен, Инк. Cd37-связывающие молекулы и их иммуноконъюгаты
WO2013175276A1 (en) * 2012-05-23 2013-11-28 Argen-X B.V Il-6 binding molecules
WO2014066167A1 (en) * 2012-10-22 2014-05-01 Fountain Biopharma Inc. Antibodies to interleukin-6 and uses thereof
RU2670943C9 (ru) * 2012-11-08 2018-11-26 Илэвэн Байотерапьютикс, Инк. Антагонисты ил-6 и их применение
EA201792300A1 (ru) 2015-06-08 2018-09-28 Дебиофарм Интернэшнл, С.А. Комбинации иммуноконъюгата к cd37 и антитела к cd20
US20170029499A1 (en) 2015-07-31 2017-02-02 Astrazeneca Pharmaceuticals Lp Methods for treating hepcidin-mediated disorders
KR102766022B1 (ko) 2015-08-28 2025-02-10 데비오팜 인터네셔날 에스 에이 Cd37 의 검출을 위한 항체 및 검정
EP3411068A4 (en) * 2016-02-02 2020-01-29 Kadmon Corporation, LLC BISPECIFIC BINDING PROTEINS FOR PD-L1 AND KDR
MX2018013523A (es) * 2016-05-05 2019-06-10 Univ Pennsylvania Anticuerpos monoclonales de adn dirigidos a il-6 y cd126.
EP3535297B1 (en) 2016-11-02 2022-08-10 Debiopharm International, S.A. Methods for improving anti-cd37 immunoconjugate therapy
JP7630906B2 (ja) 2017-02-01 2025-02-18 イェール・ユニヴァーシティー 利尿薬耐性の治療
MA51584A (fr) 2018-01-05 2020-11-11 Corvidia Therapeutics Inc Méthodes de traitement d'une inflammation médiée par il-6 sans immunosuppression
JP2021525735A (ja) 2018-05-30 2021-09-27 デビオファーム インターナショナル， エス． アー． 抗ｃｄ３７免疫コンジュゲート投薬レジメン
CN109517064B (zh) * 2018-10-10 2020-05-08 北京汇智和源生物技术有限公司 白介素-6的人源化单克隆抗体、其编码基因及应用
US20200405883A1 (en) 2019-06-20 2020-12-31 Baxalta Incorporated Method of treatment with viral-based gene therapy
CN112279913B (zh) * 2020-10-30 2022-05-03 上海百英生物科技有限公司 一种抗人il-6单克隆抗体及应用
WO2022115705A2 (en) 2020-11-30 2022-06-02 Enigma Biointelligence, Inc. Non-invasive assessment of alzheimer's disease
CN113980129B (zh) * 2021-01-15 2023-07-28 东大生物技术(苏州)有限公司 一组il-11单克隆抗体及其医药用途
CN115925792B (zh) * 2022-08-19 2025-06-27 浙江农林大学 一种香榧活性肽及其在制备降血压产品中的应用

Family Cites Families (49)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2598666B2 (ja) * 1987-10-19 1997-04-09 忠三 岸本 抗ヒトｂｃｄｆモノクローナル抗体
IL88375A (en) 1988-11-14 1995-07-31 Yeda Res & Dev Monoclonal antibodies that specifically bind interferon-bia 2 natural and recombinant and a natural and recombinant interferon-beta 2 purification method and method
WO1990005144A1 (en) 1988-11-11 1990-05-17 Medical Research Council Single domain ligands, receptors comprising said ligands, methods for their production, and use of said ligands and receptors
EP0399429A1 (en) 1989-05-22 1990-11-28 Toray Industries, Inc. Anti-human interleukin-6 monoclonal antibody
JPH03139292A (ja) * 1989-05-22 1991-06-13 Toray Ind Inc ヒトインタ―ロイキン―６に対するモノクロ―ナル抗体
JP2881311B2 (ja) * 1989-07-28 1999-04-12 味の素株式会社 抗ヒトｂｃｄｆモノクローナル抗体及びそれを用いたヒトｂｃｄｆの定量法
DE3939706C1 (enExample) * 1989-12-01 1991-03-21 Centre Regional De Transfusion Sanguine, Besancon, Fr
US5859205A (en) * 1989-12-21 1999-01-12 Celltech Limited Humanised antibodies
MX9204374A (es) 1991-07-25 1993-03-01 Idec Pharma Corp Anticuerpo recombinante y metodo para su produccion.
AU6808194A (en) 1993-05-31 1994-12-20 Chugai Seiyaku Kabushiki Kaisha Reconstructed human antibody against human interleukin-6
JP3614183B2 (ja) * 1993-05-31 2005-01-26 中外製薬株式会社 ヒトインターロイキン−６に対する再構成ヒト抗体
US5888510A (en) 1993-07-21 1999-03-30 Chugai Seiyaku Kabushiki Kaisha Chronic rheumatoid arthritis therapy containing IL-6 antagonist as effective component
EP0721783B1 (en) 1994-06-07 2005-03-16 Toray Industries, Inc. Preventive and remedy for diseases caused by fibrinoid or thrombus formation in the lung
EP0783893B1 (en) 1994-10-07 2012-04-04 Chugai Seiyaku Kabushiki Kaisha Inhibition of abnormal growth of synovial cells using il-6 antagonist as active ingredient
ATE214602T1 (de) 1994-12-29 2002-04-15 Chugai Pharmaceutical Co Ltd Verstärker eines anti-tumoragens beinhaltend einen il-6 antagonisten
GB9702944D0 (en) 1997-02-13 1997-04-02 Univ Manchester Reducing fibrosis
DK2011514T3 (da) 1997-03-21 2012-03-26 Chugai Pharmaceutical Co Ltd Forebyggende eller terapeutisk middel til sensibiliserede-T-celle-medierede sygdomme omfattende IL-6-antagonist som en aktiv bestanddel
ES2299241T3 (es) 1998-03-17 2008-05-16 Chugai Seiyaku Kabushiki Kaisha Preventivos o remedios para enfermedades intestinales inflamatorias que contienen anticuerpos antagonistas del receptor il-6.
US7494652B1 (en) 1998-06-10 2009-02-24 Promega Corporation Treatment of sepsis
EP1108435B1 (en) 1998-08-24 2007-01-03 Chugai Seiyaku Kabushiki Kaisha Preventives or remedies for pancreatitis containing anti-il-6 receptor antibodies as the active ingredient
US7083950B2 (en) 1998-09-25 2006-08-01 Regeneron Pharmaceuticals, Inc. High affinity fusion proteins and therapeutic and diagnostic methods for use
WO2000044774A2 (en) 1999-01-27 2000-08-03 The University Of South Florida Inhibition of stat3 signal transduction for human cancer therapy
US6846486B1 (en) 2000-02-24 2005-01-25 Advanced Biotherapy Concepts, Inc. Method of treating allergy by administering an anti-histamine antibody
DE60141274D1 (de) 2000-05-03 2010-03-25 Medimmune Inc Kombinationstherapie zur behandlung respiratorischer krankheiten mittels antikörper und anti-entzündungs wirkstoffe
US7320792B2 (en) 2000-10-25 2008-01-22 Chugai Seiyaku Kabushiki Kaisha Preventives or remedies for psoriasis containing as the active ingredient IL-6 antagonist
AU2000279625A1 (en) 2000-10-27 2002-05-15 Chugai Seiyaku Kabushiki Kaisha Blood mmp-3 level-lowering agent containing il-6 antgonist as the active ingredient
US20050196755A1 (en) 2000-11-17 2005-09-08 Maurice Zauderer In vitro methods of producing and identifying immunoglobulin molecules in eukaryotic cells
JP4368196B2 (ja) * 2000-11-17 2009-11-18 ユニバーシティー オブ ロチェスター 真核細胞において免疫グロブリン分子を製造および同定するインビトロにおける方法
JP2004536786A (ja) 2001-03-02 2004-12-09 メディミューン，インコーポレイテッド インテグリンαｖβ３拮抗薬を他の予防薬もしくは治療薬と組み合わせて投与することによる炎症性疾患または自己免疫疾患の予防または治療方法
AU2002250236A1 (en) 2001-03-02 2002-09-19 Medimmune, Inc. Cd2 antagonists for treatment of autoimmune or inflammatory disease
UA80091C2 (en) 2001-04-02 2007-08-27 Chugai Pharmaceutical Co Ltd Remedies for infant chronic arthritis-relating diseases and still's disease which contain an interleukin-6 (il-6) antagonist
CN100374457C (zh) * 2001-11-14 2008-03-12 森托科尔公司 抗il-6抗体、组合物、方法和用途
JP4323317B2 (ja) 2001-12-21 2009-09-02 フラームス・インテルウニフェルシタイル・インステイチュート・フォール・ビオテヒノロヒー・ヴェーゼットウェー（ヴェーイーベー・ヴェーゼットウェー） 可変領域配列のクローニング方法
US20060275294A1 (en) 2002-08-22 2006-12-07 Omoigui Osemwota S Method of prevention and treatment of aging, age-related disorders and/or age-related manifestations including atherosclerosis, peripheral vascular disease, coronary artery disease, osteoporosis, arthritis, type 2 diabetes, dementia, alzheimers disease and cancer
CN1678744B (zh) * 2002-08-30 2010-05-26 财团法人化学及血清疗法研究所 人的抗人白细胞介素-6抗体以及所述抗体的片段
AU2003290682A1 (en) 2002-11-15 2004-06-15 Centocor, Inc. Anti-angiogenic uses of il-6 antagonists
EP1594897A4 (en) 2003-02-04 2006-11-08 Centocor Inc USE OF IL-6 ANTAGONISTS IN COMBINATION WITH STEROIDS FOR INCREASED APOPTOSIS
EP1444989A1 (en) 2003-02-07 2004-08-11 Giorgio Dr. Stassi Sensitizing cells for apoptosis by selectively blocking cytokines
HRP20050837A2 (en) 2003-02-24 2005-12-31 Keio University Chugai Seiyaku Kabushiki Kaisha Remedy for spinal injury containing interleukin-6 antagonists
GB2401040A (en) 2003-04-28 2004-11-03 Chugai Pharmaceutical Co Ltd Method for treating interleukin-6 related diseases
WO2005023193A2 (en) 2003-09-04 2005-03-17 Interleukin Genetics, Inc. Methods of treating endometriosis
CN1997897A (zh) 2003-10-24 2007-07-11 梅德特龙尼克有限公司 通过削弱促炎介质的产生治疗神经病症的技术
US20050100550A1 (en) 2003-11-10 2005-05-12 Mohit Trikha Anti-angiogenic uses of IL-6 antagonists
ES2341461T5 (es) 2004-02-11 2014-10-29 Warner-Lambert Company Llc Procedimientos de tratamiento de la artrosis con anticuerpos ANTI-IL-6
EP1828250A2 (en) 2004-12-16 2007-09-05 Genentech, Inc. Methods for treating autoimmune disorders
WO2006105665A1 (en) 2005-04-06 2006-10-12 Bioartificial Gel Technologies Inc. Hydrogel composition for modulation of topical inflammatory response
EP1712241A1 (en) 2005-04-15 2006-10-18 Centre National De La Recherche Scientifique (Cnrs) Composition for treating cancer adapted for intra-tumoral administration and uses thereof
PE20061324A1 (es) 2005-04-29 2007-01-15 Centocor Inc Anticuerpos anti-il-6, composiciones, metodos y usos
EP2385061A3 (en) 2005-05-10 2012-02-22 Neoloch Aps Neuritogenic peptides

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