CO6150192A2 - Anticuerpos monoclonales anti-il-6 y usos de los mismos - Google Patents

Anticuerpos monoclonales anti-il-6 y usos de los mismos

Info

Publication number
CO6150192A2
CO6150192A2 CO09007783A CO09007783A CO6150192A2 CO 6150192 A2 CO6150192 A2 CO 6150192A2 CO 09007783 A CO09007783 A CO 09007783A CO 09007783 A CO09007783 A CO 09007783A CO 6150192 A2 CO6150192 A2 CO 6150192A2
Authority
CO
Colombia
Prior art keywords
seq
amino acid
acid sequence
group
sequence selected
Prior art date
Application number
CO09007783A
Other languages
English (en)
Inventor
Ernest S Smith
Wei Wang
Original Assignee
Vaccinex Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vaccinex Inc filed Critical Vaccinex Inc
Publication of CO6150192A2 publication Critical patent/CO6150192A2/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/244—Interleukins [IL]
    • C07K16/248—IL-6
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Immunology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Rheumatology (AREA)
  • Vascular Medicine (AREA)
  • Hematology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Oncology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

1.- Un anticuerpo monoclonal aislado, el cual comprende: (a) una región variable de cadena pesada (VH) que comprende: (i) una VH-CDR1 que comprende una secuencia de aminoácidos seleccionada a partir del grupo que consiste en las: SEQ ID NO:51, SEQ ID NO:52, SEQ ID NO:53, SEQ ID N0:54, SEQ ID NO:55, y una secuencia de aminoácidos que es idéntica a cualquiera de las SEQ ID NOs: 51 a 55 excepto por 1 a 5 sustituciones de aminoácidos; (ii) una VH-CDR2 que comprende una secuencia de aminoácidos seleccionada a partir del grupo que consiste en las: SEQ ID NO:56, SEQ ID NO:57, SEQ ID N0:58, SEQ ID NO:59, SEQ ID NO:60, SEQ ID N0:61 SEQ ID NO:97, y una secuencia de aminoácidos que es idéntica a cualquiera de las SEQ ID NOs: 56 a 61 ó 97 excepto por 1 a 5 sustituciones de aminoácidos; (iii) una VH-CDR3 que comprende una secuencia de aminoácidos seleccionada a partir del grupo que consiste en las: SEQ ID NO:62, SEQ ID NO:63, SEQ ID NO:64, SEQ ID NO:65, SEQ ID NO:66, SEQ ID NO:67, SEQ ID NO:68, SEQ ID NO:69, SEQ ID NO:70, SEQ ID NO;71, SEQ ID NO:72, SEQ ID NO:73, SEQ ID NO:98, y una secuencia de aminoácidos que es idéntica a cualquiera de las SEQ ID NOs: 62 a 73 ó 98 excepto por 1 a 5 sustituciones de aminoácidos; y (b) una región variable de cadena ligera (VL) que comprende:(i) una VL-CDR1 que comprende una secuencia de aminoácidos seleccionada a partir del grupo que consiste en las: SEQ ID NO:74, SEQ ID NO:75, SEQ ID NO:76, SEQ ID NO:77, SEQ ID NO:78, SEQ ID NO: 79, y una secuencia de aminoácidos que es idéntica a cualquiera de las SEQ ID NOs: 74 a 79 excepto por 1 a 5 sustituciones de aminoácidos; (ii) una VL-CDR2 que comprende una secuencia de aminoácidos seleccionada a partir del grupo que consiste en las: SEQ ID NO:80, SEQ ID NO:81, SEQ ID NO:82, SEQ ID NO:83, SEQ ID NO:84, SEQ ID NO:85, y una secuencia de aminoácidos que es idéntica a cualquiera de las SEQ ID NOs: 80 a 85 excepto por 1 a 5 sustituciones de aminoácidos; (iii) una VL-CDR3 que comprende una secuencia de aminoácidos seleccionada a partir del grupo que consiste en las: SEQ ID NO:86, SEQ ID NO:87, SEQ ID NO:88, SEQ ID NO:89, SEQ ID NO:90, SEQ ID NO:91, SEQ ID NO:92, SEQ ID NO:93, SEQ ID NO:94, SEQ ID NO:95, SEQ ID NO:96, ...
CO09007783A 2006-08-03 2009-01-28 Anticuerpos monoclonales anti-il-6 y usos de los mismos CO6150192A2 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US83510706P 2006-08-03 2006-08-03

Publications (1)

Publication Number Publication Date
CO6150192A2 true CO6150192A2 (es) 2010-04-20

Family

ID=39033490

Family Applications (1)

Application Number Title Priority Date Filing Date
CO09007783A CO6150192A2 (es) 2006-08-03 2009-01-28 Anticuerpos monoclonales anti-il-6 y usos de los mismos

Country Status (17)

Country Link
US (1) US7919095B2 (es)
EP (1) EP2064241B1 (es)
JP (1) JP2009545319A (es)
KR (1) KR101479537B1 (es)
CN (1) CN101563365B (es)
AU (1) AU2007282023B2 (es)
BR (1) BRPI0715115A2 (es)
CA (1) CA2657763C (es)
CO (1) CO6150192A2 (es)
CR (1) CR10563A (es)
EA (1) EA200900037A1 (es)
IL (1) IL196550A0 (es)
MA (1) MA30653B1 (es)
MX (1) MX2009001110A (es)
NO (1) NO20090224L (es)
WO (1) WO2008019061A2 (es)
ZA (1) ZA200900514B (es)

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Publication number Publication date
BRPI0715115A2 (pt) 2013-06-04
KR101479537B1 (ko) 2015-01-07
ZA200900514B (en) 2010-04-28
IL196550A0 (en) 2011-08-01
US20080075726A1 (en) 2008-03-27
CN101563365A (zh) 2009-10-21
KR20090039801A (ko) 2009-04-22
AU2007282023A1 (en) 2008-02-14
EP2064241B1 (en) 2015-10-07
WO2008019061A2 (en) 2008-02-14
CA2657763C (en) 2016-05-31
CN101563365B (zh) 2012-10-31
WO2008019061A3 (en) 2008-10-09
US7919095B2 (en) 2011-04-05
EA200900037A1 (ru) 2009-10-30
NO20090224L (no) 2009-03-31
MA30653B1 (fr) 2009-08-03
MX2009001110A (es) 2009-05-11
CA2657763A1 (en) 2008-02-14
AU2007282023B2 (en) 2012-09-13
CR10563A (es) 2009-04-14
JP2009545319A (ja) 2009-12-24
EP2064241A2 (en) 2009-06-03

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