CR10563A - Anticuerpos monoclonales ant-il-6 y usos de los mismos - Google Patents
Anticuerpos monoclonales ant-il-6 y usos de los mismosInfo
- Publication number
- CR10563A CR10563A CR10563A CR10563A CR10563A CR 10563 A CR10563 A CR 10563A CR 10563 A CR10563 A CR 10563A CR 10563 A CR10563 A CR 10563A CR 10563 A CR10563 A CR 10563A
- Authority
- CR
- Costa Rica
- Prior art keywords
- monoclonal antibodies
- ant
- same
- amino acid
- well
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
- C07K16/244—Interleukins [IL]
- C07K16/248—IL-6
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Rheumatology (AREA)
- Hematology (AREA)
- Physical Education & Sports Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Vascular Medicine (AREA)
- Oncology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Pain & Pain Management (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
La presente invencion proporciona novedosos anitcuerpos monoclonales que se enlazan especificamente con IL-6. Los anticuerpos de la invencion comprenden una region de cadena pesada variable (VH) a partir de cualquiera de las regiones VH dadas a conocer en la presente, asi como las variantes de aminoacidos de las mismas, y/0 una region de cadena ligera variable (VL) seleccionada a partir de cualquiera de las regiones VL dadas a conocer en la presente, asi como las variantes de aminoacidos de las mismas.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US83510706P | 2006-08-03 | 2006-08-03 |
Publications (1)
Publication Number | Publication Date |
---|---|
CR10563A true CR10563A (es) | 2009-04-14 |
Family
ID=39033490
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CR10563A CR10563A (es) | 2006-08-03 | 2009-01-15 | Anticuerpos monoclonales ant-il-6 y usos de los mismos |
Country Status (17)
Country | Link |
---|---|
US (1) | US7919095B2 (es) |
EP (1) | EP2064241B1 (es) |
JP (1) | JP2009545319A (es) |
KR (1) | KR101479537B1 (es) |
CN (1) | CN101563365B (es) |
AU (1) | AU2007282023B2 (es) |
BR (1) | BRPI0715115A2 (es) |
CA (1) | CA2657763C (es) |
CO (1) | CO6150192A2 (es) |
CR (1) | CR10563A (es) |
EA (1) | EA200900037A1 (es) |
IL (1) | IL196550A0 (es) |
MA (1) | MA30653B1 (es) |
MX (1) | MX2009001110A (es) |
NO (1) | NO20090224L (es) |
WO (1) | WO2008019061A2 (es) |
ZA (1) | ZA200900514B (es) |
Families Citing this family (43)
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TW200831528A (en) | 2006-11-30 | 2008-08-01 | Astrazeneca Ab | Compounds |
US8062864B2 (en) | 2007-05-21 | 2011-11-22 | Alderbio Holdings Llc | Nucleic acids encoding antibodies to IL-6, and recombinant production of anti-IL-6 antibodies |
US9701747B2 (en) | 2007-05-21 | 2017-07-11 | Alderbio Holdings Llc | Method of improving patient survivability and quality of life by anti-IL-6 antibody administration |
US8404235B2 (en) | 2007-05-21 | 2013-03-26 | Alderbio Holdings Llc | Antagonists of IL-6 to raise albumin and/or lower CRP |
US8252286B2 (en) | 2007-05-21 | 2012-08-28 | Alderbio Holdings Llc | Antagonists of IL-6 to prevent or treat thrombosis |
US8178101B2 (en) | 2007-05-21 | 2012-05-15 | Alderbio Holdings Inc. | Use of anti-IL-6 antibodies having specific binding properties to treat cachexia |
WO2008144763A2 (en) | 2007-05-21 | 2008-11-27 | Alder Biopharmaceuticals, Inc. | Antibodies to il-6 and use thereof |
US7906117B2 (en) | 2007-05-21 | 2011-03-15 | Alderbio Holdings Llc | Antagonists of IL-6 to prevent or treat cachexia, weakness, fatigue, and/or fever |
US20090238825A1 (en) * | 2007-05-21 | 2009-09-24 | Kovacevich Brian R | Novel rabbit antibody humanization methods and humanized rabbit antibodies |
DK2297202T3 (en) | 2008-05-13 | 2016-03-21 | Novimmune Sa | ANTI-IL-6 / IL-6R ANTIBODIES AND PROCEDURES FOR USE THEREOF |
US8188235B2 (en) * | 2008-06-18 | 2012-05-29 | Pfizer Inc. | Antibodies to IL-6 and their uses |
WO2010036851A2 (en) * | 2008-09-26 | 2010-04-01 | Wyeth Llc | Single chain antibody library design |
JP5789192B2 (ja) * | 2008-11-13 | 2015-10-07 | フェムタ ファーマシューティカルズ インコーポレイテッドFemta Pharmaceuticals,Inc. | ヒト化抗il−6抗体 |
US9452227B2 (en) | 2008-11-25 | 2016-09-27 | Alderbio Holdings Llc | Methods of treating or diagnosing conditions associated with elevated IL-6 using anti-IL-6 antibodies or fragments |
US8337847B2 (en) | 2008-11-25 | 2012-12-25 | Alderbio Holdings Llc | Methods of treating anemia using anti-IL-6 antibodies |
US8420089B2 (en) | 2008-11-25 | 2013-04-16 | Alderbio Holdings Llc | Antagonists of IL-6 to raise albumin and/or lower CRP |
EP2361095B1 (en) | 2008-11-25 | 2017-12-20 | AlderBio Holdings LLC | Antagonists of il-6 to raise albumin and/or lower crp |
US9212223B2 (en) | 2008-11-25 | 2015-12-15 | Alderbio Holdings Llc | Antagonists of IL-6 to prevent or treat thrombosis |
US8992920B2 (en) | 2008-11-25 | 2015-03-31 | Alderbio Holdings Llc | Anti-IL-6 antibodies for the treatment of arthritis |
US8323649B2 (en) * | 2008-11-25 | 2012-12-04 | Alderbio Holdings Llc | Antibodies to IL-6 and use thereof |
EP2477647B1 (en) | 2009-09-14 | 2016-01-13 | The Regents of the University of Colorado | Modulation of yeast-based immunotherapy products and responses |
US9775921B2 (en) | 2009-11-24 | 2017-10-03 | Alderbio Holdings Llc | Subcutaneously administrable composition containing anti-IL-6 antibody |
EP2504030A4 (en) | 2009-11-24 | 2013-06-26 | Alderbio Holdings Llc | IL-6 ANTAGONISTS FOR INCREASING ALBUMIN AND / OR REDUCING CRP |
BR112012023010A8 (pt) | 2010-03-12 | 2017-12-26 | Immunogen Inc | Anticorpo ou fragmento de ligação a antígeno do mesmo que se liga especificamente a cd37, imunoconjugado compreendendo os mesmos, uso dos referidos anticorpo, fragmento e imunoconjugado, composição compreendendo os mesmos, kit, célula isolada, bem como método in vitro para inibir o crescimento de uma célula que expressa cd37 |
ES2847891T3 (es) | 2010-11-23 | 2021-08-04 | Vitaeris Inc | Anticuerpos anti-IL-6 para el tratamiento de la mucositis oral |
WO2012098238A1 (en) | 2011-01-21 | 2012-07-26 | Novimmune S.A. | Combination therapies and methods using anti-cd3 modulating agents and anti-il-6 antagonists |
EA201391342A1 (ru) * | 2011-04-01 | 2014-11-28 | Иммьюноджен, Инк. | Cd37-связывающие молекулы и их иммуноконъюгаты |
WO2013175276A1 (en) * | 2012-05-23 | 2013-11-28 | Argen-X B.V | Il-6 binding molecules |
CN103772503B (zh) | 2012-10-22 | 2017-05-10 | 泉盛生物科技股份有限公司 | 介白素‑6抗体及其用途 |
CN104903349B (zh) * | 2012-11-08 | 2018-10-19 | 十一生物治疗股份有限公司 | Il-6拮抗剂及其应用 |
US20170000900A1 (en) | 2015-06-08 | 2017-01-05 | Immunogen, Inc. | Anti-cd37 immunoconjugate and anti-cd20 antibody combinations |
EP3329018B1 (en) | 2015-07-31 | 2021-03-31 | Medimmune Limited | Il-6 antagonists for use in treating hepcidin-mediated disorders |
EP3341414A4 (en) | 2015-08-28 | 2019-03-27 | Debiopharm International SA | ANTIBODIES AND ASSAYS FOR DETECTION OF CD37 |
EA201891732A1 (ru) * | 2016-02-02 | 2019-02-28 | Кадмон Корпорейшн, Ллк | Биспецифичные связывающие белки для pd-l1 и kdr |
CN109789224A (zh) * | 2016-05-05 | 2019-05-21 | 宾夕法尼亚大学理事会 | 靶向il-6和cd126的dna单克隆抗体 |
WO2018083633A1 (en) | 2016-11-02 | 2018-05-11 | Debiopharm International, S.A. | Methods for improving anti-cd37 immunoconjugate therapy |
EP3576790A4 (en) | 2017-02-01 | 2020-12-23 | Yale University | TREATMENT OF DIURETIC RESISTANCE |
CA3087699A1 (en) | 2018-01-05 | 2019-07-11 | Corvidia Therapeutics, Inc. | Methods for treating il-6 mediated inflammation without immunosuppression |
CN109517064B (zh) * | 2018-10-10 | 2020-05-08 | 北京汇智和源生物技术有限公司 | 白介素-6的人源化单克隆抗体、其编码基因及应用 |
EP3986481A2 (en) | 2019-06-20 | 2022-04-27 | Takeda Pharmaceutical Company Limited | Method of treatment with viral-based gene therapy |
CN112279913B (zh) * | 2020-10-30 | 2022-05-03 | 上海百英生物科技有限公司 | 一种抗人il-6单克隆抗体及应用 |
JP2023551542A (ja) | 2020-11-30 | 2023-12-08 | エニグマ バイオインテリジェンス,インコーポレイテッド | アルツハイマー病の非侵襲的評価 |
CN113980129B (zh) * | 2021-01-15 | 2023-07-28 | 东大生物技术(苏州)有限公司 | 一组il-11单克隆抗体及其医药用途 |
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CN1507354A (zh) | 2001-03-02 | 2004-06-23 | ͨ��ҽ�ƹ�˾ | 通过给予整合蛋白αvβ3拮抗剂并与其它预防或治疗药剂配合来预防或者治疗炎性疾病或自身免疫疾病的方法 |
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-
2007
- 2007-08-03 WO PCT/US2007/017337 patent/WO2008019061A2/en active Application Filing
- 2007-08-03 BR BRPI0715115-2A patent/BRPI0715115A2/pt not_active Application Discontinuation
- 2007-08-03 MX MX2009001110A patent/MX2009001110A/es not_active Application Discontinuation
- 2007-08-03 CA CA2657763A patent/CA2657763C/en not_active Expired - Fee Related
- 2007-08-03 JP JP2009522880A patent/JP2009545319A/ja active Pending
- 2007-08-03 EP EP07811042.6A patent/EP2064241B1/en active Active
- 2007-08-03 US US11/882,751 patent/US7919095B2/en not_active Expired - Fee Related
- 2007-08-03 AU AU2007282023A patent/AU2007282023B2/en not_active Ceased
- 2007-08-03 EA EA200900037A patent/EA200900037A1/ru unknown
- 2007-08-03 CN CN2007800289537A patent/CN101563365B/zh not_active Expired - Fee Related
- 2007-08-03 KR KR20097003512A patent/KR101479537B1/ko not_active IP Right Cessation
-
2009
- 2009-01-15 CR CR10563A patent/CR10563A/es unknown
- 2009-01-15 IL IL196550A patent/IL196550A0/en unknown
- 2009-01-15 NO NO20090224A patent/NO20090224L/no not_active Application Discontinuation
- 2009-01-22 ZA ZA200900514A patent/ZA200900514B/xx unknown
- 2009-01-28 CO CO09007783A patent/CO6150192A2/es unknown
- 2009-02-17 MA MA31649A patent/MA30653B1/fr unknown
Also Published As
Publication number | Publication date |
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IL196550A0 (en) | 2011-08-01 |
EA200900037A1 (ru) | 2009-10-30 |
WO2008019061A2 (en) | 2008-02-14 |
NO20090224L (no) | 2009-03-31 |
AU2007282023B2 (en) | 2012-09-13 |
MA30653B1 (fr) | 2009-08-03 |
CA2657763C (en) | 2016-05-31 |
CN101563365B (zh) | 2012-10-31 |
BRPI0715115A2 (pt) | 2013-06-04 |
AU2007282023A1 (en) | 2008-02-14 |
KR20090039801A (ko) | 2009-04-22 |
US7919095B2 (en) | 2011-04-05 |
CA2657763A1 (en) | 2008-02-14 |
CO6150192A2 (es) | 2010-04-20 |
US20080075726A1 (en) | 2008-03-27 |
MX2009001110A (es) | 2009-05-11 |
CN101563365A (zh) | 2009-10-21 |
KR101479537B1 (ko) | 2015-01-07 |
ZA200900514B (en) | 2010-04-28 |
WO2008019061A3 (en) | 2008-10-09 |
EP2064241A2 (en) | 2009-06-03 |
JP2009545319A (ja) | 2009-12-24 |
EP2064241B1 (en) | 2015-10-07 |
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