CO6251325A2 - Un anticuerpo humano o humanizado, o un fragmento del mismo con una region de enlace de antigeno que es especifica para dirigir la proteina al receptor de limfoproteina estromal timica humana (htslpr) - Google Patents
Un anticuerpo humano o humanizado, o un fragmento del mismo con una region de enlace de antigeno que es especifica para dirigir la proteina al receptor de limfoproteina estromal timica humana (htslpr)Info
- Publication number
- CO6251325A2 CO6251325A2 CO09144825A CO09144825A CO6251325A2 CO 6251325 A2 CO6251325 A2 CO 6251325A2 CO 09144825 A CO09144825 A CO 09144825A CO 09144825 A CO09144825 A CO 09144825A CO 6251325 A2 CO6251325 A2 CO 6251325A2
- Authority
- CO
- Colombia
- Prior art keywords
- seq
- human
- variable region
- sequence
- chain variable
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2866—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A61P31/08—Antibacterial agents for leprosy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pulmonology (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Otolaryngology (AREA)
- Dermatology (AREA)
- Rheumatology (AREA)
- Communicable Diseases (AREA)
- Pain & Pain Management (AREA)
- Oncology (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
1.- Un anticuerpo aislado o una porción de enlace de antígeno del mismo, el cual comprende una secuencia de la región variable de cadena pesada de la SEQ ID NO: 7 o de la SEQ ID NO: 21. 2.- Un anticuerpo aislado o una porción de enlace de antígeno del mismo, el cual comprende una secuencia de la región variable de cadena pesada de la SEQ ID NO: 7, y una secuencia de la región variable de cadena ligera de la SEQ ID NO: 8, o una secuencia de la región variable de cadena pesada de la SEQ ID NO: 21, y una secuencia de la región variable de cadena ligera de la SEQ ID NO: 22. 3.- El anticuerpo de la reivindicación 2, el cual comprende CDRH1, H2 y H3 de las SEQ ID NOs: 1, 2, y 3, respectivamente, o de las SEQ ID NOs: 15, 16, y 17, respectivamente, o una secuencia de CDRL1, L2 y L3 de las SEQ ID NOs: 4, 5, y 6, respectivamente, o de las SEQ ID NOs: 18, 19, y 20, respectivamente. 4.- El anticuerpo de la reivindicación 2, el cual comprende las CDRH1, H2 y H3 de las SEQ ID Nos: 1, 2, y 3, respectivamente, o de las SEQ ID Nos: 15, 16, y 17, respectivamente, y una secuencia de CDRL1, L2, y L3 de las SEQ ID NOs: 4, 5, y 6, respectivamente, o de las SEQ ID NO: 18, 19, y 20, respectivamente. 5.- El anticuerpo de la reivindicación 2, el cual comprende una secuencia de aminoácidos de la región variable de cadena pesada que es cuando menos el 80 por ciento idéntica a la SEQ ID NO: 7, y una secuencia de aminoácidos de la región variable de cadena ligera que es cuando menos el 80 por ciento idéntica a la SEQ ID NO: 8, o que comprende una secuencia de aminoácidos de la región variable de cadena pesada que es cuando menos el 80 por ciento idéntica a la SEQ ID NO: 21, y una secuencia de aminoácidos de la región variable de cadena ligera que es cuando menos el 80 por ciento idéntica a la SEQ ID NO: 22. 6.- El anticuerpo de la reivindicación 2, el cual es un anticuerpo quimérico.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US94520507P | 2007-06-20 | 2007-06-20 |
Publications (1)
Publication Number | Publication Date |
---|---|
CO6251325A2 true CO6251325A2 (es) | 2011-02-21 |
Family
ID=39846944
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CO09144825A CO6251325A2 (es) | 2007-06-20 | 2009-12-17 | Un anticuerpo humano o humanizado, o un fragmento del mismo con una region de enlace de antigeno que es especifica para dirigir la proteina al receptor de limfoproteina estromal timica humana (htslpr) |
Country Status (20)
Country | Link |
---|---|
US (1) | US8101182B2 (es) |
EP (1) | EP2170957A1 (es) |
JP (1) | JP2010530233A (es) |
KR (1) | KR20100034015A (es) |
CN (1) | CN102027012A (es) |
AR (1) | AR067045A1 (es) |
AU (1) | AU2008265128A1 (es) |
BR (1) | BRPI0813725A2 (es) |
CA (1) | CA2691157A1 (es) |
CL (1) | CL2008001826A1 (es) |
CO (1) | CO6251325A2 (es) |
CR (1) | CR11152A (es) |
EA (1) | EA201000006A1 (es) |
EC (1) | ECSP099812A (es) |
IL (1) | IL202573A0 (es) |
PE (1) | PE20090768A1 (es) |
TN (1) | TN2009000529A1 (es) |
TW (1) | TW200918557A (es) |
WO (1) | WO2008155365A1 (es) |
ZA (1) | ZA200908711B (es) |
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JP5436753B2 (ja) * | 2003-07-18 | 2014-03-05 | メルク・シャープ・アンド・ドーム・コーポレーション | 胸腺間質性リンホポエチンを使用する、新生物の処置および診断 |
US20050249712A1 (en) * | 2004-03-23 | 2005-11-10 | The Government Of The Usa As Represented By The Secretary Of The Dept. Of Health & Human Services | Methods for use of TSLP and agonists and antagonists thereof |
EP1793856A2 (en) * | 2004-08-20 | 2007-06-13 | Amgen Inc. | Methods and compositions for treating allergic inflammation |
US20060171943A1 (en) | 2005-02-01 | 2006-08-03 | Amgen Inc. | Compositions and methods of treating fibrotic disorders |
CN101370831B (zh) | 2006-01-13 | 2013-06-19 | Irm责任有限公司 | 用于治疗过敏性疾病的针对胸腺基质淋巴细胞生成素受体的抗体 |
JP2011511638A (ja) | 2008-02-07 | 2011-04-14 | シェーリング コーポレイション | 抗tslpr抗体の設計製作 |
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- 2008-06-18 EA EA201000006A patent/EA201000006A1/ru unknown
- 2008-06-18 AR ARP080102594A patent/AR067045A1/es not_active Application Discontinuation
- 2008-06-18 WO PCT/EP2008/057731 patent/WO2008155365A1/en active Application Filing
- 2008-06-18 EP EP08761179A patent/EP2170957A1/en not_active Withdrawn
- 2008-06-18 PE PE2008001045A patent/PE20090768A1/es not_active Application Discontinuation
- 2008-06-18 JP JP2010512681A patent/JP2010530233A/ja active Pending
- 2008-06-18 CN CN2008801025460A patent/CN102027012A/zh active Pending
- 2008-06-18 AU AU2008265128A patent/AU2008265128A1/en not_active Abandoned
- 2008-06-18 US US12/141,516 patent/US8101182B2/en not_active Expired - Fee Related
- 2008-06-18 CA CA2691157A patent/CA2691157A1/en not_active Abandoned
- 2008-06-18 KR KR1020107001185A patent/KR20100034015A/ko not_active Application Discontinuation
- 2008-06-18 BR BRPI0813725-0A2A patent/BRPI0813725A2/pt not_active IP Right Cessation
- 2008-06-19 CL CL2008001826A patent/CL2008001826A1/es unknown
- 2008-06-19 TW TW097122910A patent/TW200918557A/zh unknown
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- 2009-12-08 ZA ZA200908711A patent/ZA200908711B/xx unknown
- 2009-12-09 CR CR11152A patent/CR11152A/es not_active Application Discontinuation
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Also Published As
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BRPI0813725A2 (pt) | 2014-12-30 |
US20090074747A1 (en) | 2009-03-19 |
TW200918557A (en) | 2009-05-01 |
EA201000006A1 (ru) | 2010-10-29 |
US8101182B2 (en) | 2012-01-24 |
CA2691157A1 (en) | 2008-12-24 |
IL202573A0 (en) | 2011-08-01 |
ECSP099812A (es) | 2010-01-29 |
WO2008155365A1 (en) | 2008-12-24 |
TN2009000529A1 (en) | 2011-03-31 |
CR11152A (es) | 2010-01-20 |
JP2010530233A (ja) | 2010-09-09 |
PE20090768A1 (es) | 2009-07-09 |
AU2008265128A1 (en) | 2008-12-24 |
CN102027012A (zh) | 2011-04-20 |
ZA200908711B (en) | 2010-08-25 |
EP2170957A1 (en) | 2010-04-07 |
CL2008001826A1 (es) | 2009-02-20 |
KR20100034015A (ko) | 2010-03-31 |
AR067045A1 (es) | 2009-09-30 |
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