MX2021014733A - Metodos de identificacion de atributos de proteinas terapeuticas. - Google Patents

Metodos de identificacion de atributos de proteinas terapeuticas.

Info

Publication number
MX2021014733A
MX2021014733A MX2021014733A MX2021014733A MX2021014733A MX 2021014733 A MX2021014733 A MX 2021014733A MX 2021014733 A MX2021014733 A MX 2021014733A MX 2021014733 A MX2021014733 A MX 2021014733A MX 2021014733 A MX2021014733 A MX 2021014733A
Authority
MX
Mexico
Prior art keywords
unbound
therapeutic proteins
target
therapeutic
targets
Prior art date
Application number
MX2021014733A
Other languages
English (en)
Inventor
Pavel Bondarenko
Andrew Nichols
Scott Thomas Kuhns
Jill A Crouse-Zeineddini
Gang Xiao
Rachel Liuqing Shi
Original Assignee
Amgen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Amgen Inc filed Critical Amgen Inc
Publication of MX2021014733A publication Critical patent/MX2021014733A/es

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6845—Methods of identifying protein-protein interactions in protein mixtures
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6848—Methods of protein analysis involving mass spectrometry
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54306—Solid-phase reaction mechanisms
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/544—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being organic
    • G01N33/545—Synthetic resin
    • G01N33/547—Synthetic resin with antigen or antibody attached to the carrier via a bridging agent
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
    • G01N2500/20—Screening for compounds of potential therapeutic value cell-free systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Cell Biology (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Peptides Or Proteins (AREA)

Abstract

En el presente documento se proporcionan métodos de identificación de estructuras, por ejemplo, atributos, de una proteína terapéutica o una diana, que afectan a una interacción entre la proteína terapéutica y la diana. En realizaciones ilustrativas, el método comprende: (a) aplicar un estrés a una primera muestra que comprende proteínas terapéuticas o dianas; (b) poner en contacto la primera muestra con una segunda muestra que comprende dianas o proteínas terapéuticas para formar una mezcla que comprende (i) complejos de proteína terapéutica-diana, (ii) proteínas terapéuticas no unidas y (iii) dianas no unidas; y (c) separar la mezcla en al menos dos fracciones, en donde una fracción no unida comprende proteínas terapéuticas no unidas o dianas no unidas y una fracción unida comprende complejos de proteína terapéutica-diana; y (d) para cada una de la fracción no unida y la fracción unida, identificar y cuantificar la abundancia de las estructuras, por ejemplo, un atributo, presentes en una especie de la proteína terapéutica o diana.
MX2021014733A 2019-06-05 2020-06-05 Metodos de identificacion de atributos de proteinas terapeuticas. MX2021014733A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201962857637P 2019-06-05 2019-06-05
US202062968682P 2020-01-31 2020-01-31
PCT/US2020/036380 WO2020247790A1 (en) 2019-06-05 2020-06-05 Methods of identifying attributes of therapeutic proteins

Publications (1)

Publication Number Publication Date
MX2021014733A true MX2021014733A (es) 2022-04-06

Family

ID=71944196

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2021014733A MX2021014733A (es) 2019-06-05 2020-06-05 Metodos de identificacion de atributos de proteinas terapeuticas.

Country Status (8)

Country Link
US (1) US20220260584A1 (es)
EP (1) EP3980786A1 (es)
JP (1) JP2022535042A (es)
AU (1) AU2020288652A1 (es)
CA (1) CA3138941A1 (es)
MA (1) MA56121A (es)
MX (1) MX2021014733A (es)
WO (1) WO2020247790A1 (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2021108237A1 (en) * 2019-11-26 2021-06-03 Merck Sharp & Dohme Corp. On-line ultra performance hydrophobic interaction chromatography for monitoring at least one product attribute
EP4295158A1 (en) * 2021-02-19 2023-12-27 Waters Technologies Corporation Methods for peptide mapping of adeno-associated virus (aav) proteins
CR20230531A (es) 2021-04-23 2024-01-08 Amgen Inc Composiciones de anticuerpos anti-tslp y usos de las mismas
CN117177992A (zh) 2021-04-23 2023-12-05 美国安进公司 经修饰的抗tslp抗体
CN117716237A (zh) * 2021-07-13 2024-03-15 瑞泽恩制药公司 用于确定生物制剂的产物相关变体的基于质谱法的策略
AU2022324624A1 (en) 2021-08-06 2024-02-08 Amgen Inc. Isolation of therapeutic protein

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RS51829B (sr) 2001-08-23 2012-02-29 Genmab A/S. Ljudska antitela specifična za interleukin 15 (il-15)
US7592429B2 (en) 2005-05-03 2009-09-22 Ucb Sa Sclerostin-binding antibody
US8003108B2 (en) 2005-05-03 2011-08-23 Amgen Inc. Sclerostin epitopes
AU2008265128A1 (en) 2007-06-20 2008-12-24 Irm Llc Methods and compositions for treating allergic diseases
US7982016B2 (en) 2007-09-10 2011-07-19 Amgen Inc. Antigen binding proteins capable of binding thymic stromal lymphopoietin
TWI516501B (zh) 2008-09-12 2016-01-11 禮納特神經系統科學公司 Ｐｃｓｋ９拮抗劑類

Also Published As

Publication number Publication date
CA3138941A1 (en) 2020-12-10
WO2020247790A1 (en) 2020-12-10
MA56121A (fr) 2022-04-13
US20220260584A1 (en) 2022-08-18
AU2020288652A1 (en) 2021-11-18
JP2022535042A (ja) 2022-08-04
EP3980786A1 (en) 2022-04-13

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