BR112023000603A2 - Proteínas sars-cov-2, anticorpos anti-sars-cov-2 e métodos de uso dos mesmos - Google Patents

Proteínas sars-cov-2, anticorpos anti-sars-cov-2 e métodos de uso dos mesmos

Info

Publication number
BR112023000603A2
BR112023000603A2 BR112023000603A BR112023000603A BR112023000603A2 BR 112023000603 A2 BR112023000603 A2 BR 112023000603A2 BR 112023000603 A BR112023000603 A BR 112023000603A BR 112023000603 A BR112023000603 A BR 112023000603A BR 112023000603 A2 BR112023000603 A2 BR 112023000603A2
Authority
BR
Brazil
Prior art keywords
cov
sars
antibodies
proteins
methods
Prior art date
Application number
BR112023000603A
Other languages
English (en)
Inventor
Hughes Glen
E March Ruth
Esser Mark
MCTAMNEY II Patrick
LOO Yueh-Ming
M Varkey Reena
Du Qun
Steinhardt James
Rajan Saravanan
Original Assignee
Astrazeneca Uk Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Uk Ltd filed Critical Astrazeneca Uk Ltd
Publication of BR112023000603A2 publication Critical patent/BR112023000603A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
    • C07K16/10—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from RNA viruses
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56983—Viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
    • C07K16/10—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from RNA viruses
    • C07K16/1002—Coronaviridae
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
    • C07K16/10—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from RNA viruses
    • C07K16/1002—Coronaviridae
    • C07K16/1003—Severe acute respiratory syndrome coronavirus 2 [SARS‐CoV‐2 or Covid-19]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366—Apparatus specially adapted for solid-phase testing
    • G01N33/54386—Analytical elements
    • G01N33/54387—Immunochromatographic test strips
    • G01N33/54388—Immunochromatographic test strips based on lateral flow
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2469/00—Immunoassays for the detection of microorganisms
    • G01N2469/20—Detection of antibodies in sample from host which are directed against antigens from microorganisms

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Virology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Cell Biology (AREA)
  • Pathology (AREA)
  • Food Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Pulmonology (AREA)
  • Plant Pathology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

PROTEÍNAS SARS-COV-2, ANTICORPOS ANTI-SARS-COV-2 E MÉTODOS DE USO DOS MESMOS. A presente invenção refere-se a proteínas spike de SARS-CoV-2 e trímeros contendo tais proteínas spike. A presente invenção também se refere a anticorpos e fragmentos de ligação a antígeno dos mesmos que se ligam especificamente à proteína spike de SARS-CoV-2. As proteínas, trímeros e anticorpos podem ser usados, por exemplo, para detectar anticorpos anti-SARS-CoV-2 em amostras obtidas de um indivíduo.
BR112023000603A 2020-07-20 2021-07-19 Proteínas sars-cov-2, anticorpos anti-sars-cov-2 e métodos de uso dos mesmos BR112023000603A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US202063054104P 2020-07-20 2020-07-20
PCT/EP2021/070176 WO2022018040A2 (en) 2020-07-20 2021-07-19 Sars-cov-2 proteins, anti-sars-cov-2 antibodies, and methods of using the same

Publications (1)

Publication Number Publication Date
BR112023000603A2 true BR112023000603A2 (pt) 2023-01-31

Family

ID=77274776

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112023000603A BR112023000603A2 (pt) 2020-07-20 2021-07-19 Proteínas sars-cov-2, anticorpos anti-sars-cov-2 e métodos de uso dos mesmos

Country Status (10)

Country Link
US (1) US20230279078A1 (pt)
EP (1) EP4182343A2 (pt)
JP (1) JP2023534520A (pt)
KR (1) KR20230038783A (pt)
CN (1) CN116507636A (pt)
AU (1) AU2021313348A1 (pt)
BR (1) BR112023000603A2 (pt)
CA (1) CA3188938A1 (pt)
IL (1) IL299757A (pt)
WO (1) WO2022018040A2 (pt)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2023144779A1 (en) * 2022-01-28 2023-08-03 Pfizer Inc. Coronavirus antigen variants

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GB8601597D0 (en) 1986-01-23 1986-02-26 Wilson R H Nucleotide sequences
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GB8717430D0 (en) 1987-07-23 1987-08-26 Celltech Ltd Recombinant dna product
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US5780225A (en) 1990-01-12 1998-07-14 Stratagene Method for generating libaries of antibody genes comprising amplification of diverse antibody DNAs and methods for using these libraries for the production of diverse antigen combining molecules
WO1991010737A1 (en) 1990-01-11 1991-07-25 Molecular Affinities Corporation Production of antibodies using gene libraries
US5427908A (en) 1990-05-01 1995-06-27 Affymax Technologies N.V. Recombinant library screening methods
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IE922437A1 (en) 1991-07-25 1993-01-27 Idec Pharma Corp Recombinant antibodies for human therapy
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Also Published As

Publication number Publication date
US20230279078A1 (en) 2023-09-07
CA3188938A1 (en) 2022-01-27
KR20230038783A (ko) 2023-03-21
WO2022018040A3 (en) 2022-04-14
EP4182343A2 (en) 2023-05-24
IL299757A (en) 2023-03-01
AU2021313348A1 (en) 2023-03-09
JP2023534520A (ja) 2023-08-09
CN116507636A (zh) 2023-07-28
WO2022018040A2 (en) 2022-01-27

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