AU2007282023B2 - Anti-IL-6 monoclonal antibodies and uses thereof - Google Patents
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- AU2007282023B2 AU2007282023B2 AU2007282023A AU2007282023A AU2007282023B2 AU 2007282023 B2 AU2007282023 B2 AU 2007282023B2 AU 2007282023 A AU2007282023 A AU 2007282023A AU 2007282023 A AU2007282023 A AU 2007282023A AU 2007282023 B2 AU2007282023 B2 AU 2007282023B2
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Classifications
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- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
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- C—CHEMISTRY; METALLURGY
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- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
- C07K16/244—Interleukins [IL]
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- C07K—PEPTIDES
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- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
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Landscapes
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| US8404235B2 (en) | 2007-05-21 | 2013-03-26 | Alderbio Holdings Llc | Antagonists of IL-6 to raise albumin and/or lower CRP |
| US9701747B2 (en) | 2007-05-21 | 2017-07-11 | Alderbio Holdings Llc | Method of improving patient survivability and quality of life by anti-IL-6 antibody administration |
| US20090238825A1 (en) * | 2007-05-21 | 2009-09-24 | Kovacevich Brian R | Novel rabbit antibody humanization methods and humanized rabbit antibodies |
| US8252286B2 (en) | 2007-05-21 | 2012-08-28 | Alderbio Holdings Llc | Antagonists of IL-6 to prevent or treat thrombosis |
| CN105001332B (zh) | 2007-05-21 | 2018-12-04 | 奥尔德生物控股有限责任公司 | 针对il-6的抗体及其用途 |
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| US8188235B2 (en) * | 2008-06-18 | 2012-05-29 | Pfizer Inc. | Antibodies to IL-6 and their uses |
| JP2012503490A (ja) * | 2008-09-26 | 2012-02-09 | ワイス・エルエルシー | 単鎖抗体ライブラリー設計 |
| WO2010056948A2 (en) * | 2008-11-13 | 2010-05-20 | Femta Pharmaceuticals, Inc. | Humanized anti-il-6 antibodies |
| US9452227B2 (en) | 2008-11-25 | 2016-09-27 | Alderbio Holdings Llc | Methods of treating or diagnosing conditions associated with elevated IL-6 using anti-IL-6 antibodies or fragments |
| KR20110112307A (ko) * | 2008-11-25 | 2011-10-12 | 앨더 바이오파마슈티컬즈, 인코포레이티드 | 알부민을 상승시키고 및／또는 ｃｒｐ를 낮추는 ｉｌ６의 길항제 |
| US8337847B2 (en) | 2008-11-25 | 2012-12-25 | Alderbio Holdings Llc | Methods of treating anemia using anti-IL-6 antibodies |
| US8323649B2 (en) | 2008-11-25 | 2012-12-04 | Alderbio Holdings Llc | Antibodies to IL-6 and use thereof |
| US8992920B2 (en) | 2008-11-25 | 2015-03-31 | Alderbio Holdings Llc | Anti-IL-6 antibodies for the treatment of arthritis |
| US9212223B2 (en) | 2008-11-25 | 2015-12-15 | Alderbio Holdings Llc | Antagonists of IL-6 to prevent or treat thrombosis |
| US8420089B2 (en) | 2008-11-25 | 2013-04-16 | Alderbio Holdings Llc | Antagonists of IL-6 to raise albumin and/or lower CRP |
| US8911722B2 (en) | 2009-09-14 | 2014-12-16 | The Regents Of The University Of Colorado, A Body Corporate | Modulation of yeast-based immunotherapy products and responses |
| US9775921B2 (en) | 2009-11-24 | 2017-10-03 | Alderbio Holdings Llc | Subcutaneously administrable composition containing anti-IL-6 antibody |
| US20120294852A1 (en) | 2009-11-24 | 2012-11-22 | Smith Jeffrey T L | Antagonists of il-6 to raise albumin and/or lower crp |
| SMT201900549T1 (it) | 2010-03-12 | 2019-11-13 | Debiopharm Int Sa | Molecole leganti il cd37 e loro immunoconiugati |
| CA2818813C (en) | 2010-11-23 | 2020-10-06 | Alder Biopharmaceuticals, Inc. | Anti-il-6 antibodies for the treatment of oral mucositis |
| WO2012098238A1 (en) | 2011-01-21 | 2012-07-26 | Novimmune S.A. | Combination therapies and methods using anti-cd3 modulating agents and anti-il-6 antagonists |
| EA201391342A1 (ru) * | 2011-04-01 | 2014-11-28 | Иммьюноджен, Инк. | Cd37-связывающие молекулы и их иммуноконъюгаты |
| WO2013175276A1 (en) * | 2012-05-23 | 2013-11-28 | Argen-X B.V | Il-6 binding molecules |
| CA2889181C (en) * | 2012-10-22 | 2021-12-07 | Fountain Biopharma Inc. | Antibodies to interleukin-6 and uses thereof |
| CN104903349B (zh) * | 2012-11-08 | 2018-10-19 | 十一生物治疗股份有限公司 | Il-6拮抗剂及其应用 |
| MX392539B (es) | 2015-06-08 | 2025-03-24 | Debiopharm Int Sa | Combinaciones de inmunoconjugado anti-cd37 y anticuerpo anti-cd20. |
| US20170029499A1 (en) | 2015-07-31 | 2017-02-02 | Astrazeneca Pharmaceuticals Lp | Methods for treating hepcidin-mediated disorders |
| UA129489C2 (uk) | 2015-08-28 | 2025-05-14 | Дебіофарм Інтернаціонал, С.А. | Антитіло до cd37 |
| CN109310755A (zh) * | 2016-02-02 | 2019-02-05 | 卡德门企业有限公司 | Pd-l1和kdr的双特异性结合蛋白 |
| SG11201809786TA (en) * | 2016-05-05 | 2018-12-28 | Univ Pennsylvania | Dna monoclonal antibodies targeting il-6 and cd126 |
| US11278629B2 (en) | 2016-11-02 | 2022-03-22 | Debiopharm International, S.A. | Methods for improving anti-CD37 immunoconjugate therapy |
| TW202444416A (zh) | 2017-02-01 | 2024-11-16 | 耶魯大學 | 心臟衰竭及心腎症候群之精準治療 |
| KR20230047223A (ko) | 2018-01-05 | 2023-04-06 | 노보 노르디스크 에이/에스 | 면역억제 없이 il-6 매개 염증을 치료하기 위한 방법 |
| CN112218662A (zh) | 2018-05-30 | 2021-01-12 | 德彪发姆国际有限公司 | 抗cd37免疫缀合物给药方案 |
| CN109517064B (zh) * | 2018-10-10 | 2020-05-08 | 北京汇智和源生物技术有限公司 | 白介素-6的人源化单克隆抗体、其编码基因及应用 |
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| CN112279913B (zh) * | 2020-10-30 | 2022-05-03 | 上海百英生物科技有限公司 | 一种抗人il-6单克隆抗体及应用 |
| EP4252243A2 (en) | 2020-11-30 | 2023-10-04 | Enigma Biointelligence, Inc. | Non-invasive assessment of alzheimer's disease |
| CN113980129B (zh) * | 2021-01-15 | 2023-07-28 | 东大生物技术(苏州)有限公司 | 一组il-11单克隆抗体及其医药用途 |
| CN115925792B (zh) * | 2022-08-19 | 2025-06-27 | 浙江农林大学 | 一种香榧活性肽及其在制备降血压产品中的应用 |
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2007
- 2007-08-03 AU AU2007282023A patent/AU2007282023B2/en not_active Ceased
- 2007-08-03 US US11/882,751 patent/US7919095B2/en not_active Expired - Fee Related
- 2007-08-03 EP EP07811042.6A patent/EP2064241B1/en active Active
- 2007-08-03 JP JP2009522880A patent/JP2009545319A/ja active Pending
- 2007-08-03 CA CA2657763A patent/CA2657763C/en not_active Expired - Fee Related
- 2007-08-03 KR KR20097003512A patent/KR101479537B1/ko not_active Expired - Fee Related
- 2007-08-03 CN CN2007800289537A patent/CN101563365B/zh not_active Expired - Fee Related
- 2007-08-03 EA EA200900037A patent/EA200900037A1/ru unknown
- 2007-08-03 WO PCT/US2007/017337 patent/WO2008019061A2/en not_active Ceased
- 2007-08-03 BR BRPI0715115-2A patent/BRPI0715115A2/pt not_active Application Discontinuation
- 2007-08-03 MX MX2009001110A patent/MX2009001110A/es not_active Application Discontinuation
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2009
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- 2009-01-15 NO NO20090224A patent/NO20090224L/no not_active Application Discontinuation
- 2009-01-15 IL IL196550A patent/IL196550A0/en unknown
- 2009-01-22 ZA ZA200900514A patent/ZA200900514B/xx unknown
- 2009-01-28 CO CO09007783A patent/CO6150192A2/es unknown
- 2009-02-17 MA MA31649A patent/MA30653B1/fr unknown
Patent Citations (1)
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| DE3939706C1 (enExample) * | 1989-12-01 | 1991-03-21 | Centre Regional De Transfusion Sanguine, Besancon, Fr |
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| Publication number | Publication date |
|---|---|
| WO2008019061A3 (en) | 2008-10-09 |
| KR20090039801A (ko) | 2009-04-22 |
| CA2657763A1 (en) | 2008-02-14 |
| KR101479537B1 (ko) | 2015-01-07 |
| CN101563365B (zh) | 2012-10-31 |
| US20080075726A1 (en) | 2008-03-27 |
| EA200900037A1 (ru) | 2009-10-30 |
| WO2008019061A2 (en) | 2008-02-14 |
| MA30653B1 (fr) | 2009-08-03 |
| CR10563A (es) | 2009-04-14 |
| IL196550A0 (en) | 2011-08-01 |
| MX2009001110A (es) | 2009-05-11 |
| CN101563365A (zh) | 2009-10-21 |
| JP2009545319A (ja) | 2009-12-24 |
| NO20090224L (no) | 2009-03-31 |
| AU2007282023A1 (en) | 2008-02-14 |
| CA2657763C (en) | 2016-05-31 |
| EP2064241A2 (en) | 2009-06-03 |
| BRPI0715115A2 (pt) | 2013-06-04 |
| ZA200900514B (en) | 2010-04-28 |
| EP2064241B1 (en) | 2015-10-07 |
| CO6150192A2 (es) | 2010-04-20 |
| US7919095B2 (en) | 2011-04-05 |
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