ATE552012T1 - Hemmung des abnormalen wachstums von synovialzellen durch il-6-antagonisten als wirkstoff - Google Patents
Hemmung des abnormalen wachstums von synovialzellen durch il-6-antagonisten als wirkstoffInfo
- Publication number
- ATE552012T1 ATE552012T1 AT95921130T AT95921130T ATE552012T1 AT E552012 T1 ATE552012 T1 AT E552012T1 AT 95921130 T AT95921130 T AT 95921130T AT 95921130 T AT95921130 T AT 95921130T AT E552012 T1 ATE552012 T1 AT E552012T1
- Authority
- AT
- Austria
- Prior art keywords
- antagonists
- inhibition
- active substance
- abnormal growth
- synovial cells
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
- C07K16/244—Interleukins [IL]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
- C07K16/244—Interleukins [IL]
- C07K16/248—IL-6
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2866—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Rheumatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Biomedical Technology (AREA)
- Pain & Pain Management (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
- Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP24403594 | 1994-10-07 | ||
| PCT/JP1995/001144 WO1996011020A1 (en) | 1994-10-07 | 1995-06-07 | Rheumatoid arthritis remedy containing il-6 antagonist as active ingredient |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE552012T1 true ATE552012T1 (de) | 2012-04-15 |
Family
ID=17112746
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT95921130T ATE552012T1 (de) | 1994-10-07 | 1995-06-07 | Hemmung des abnormalen wachstums von synovialzellen durch il-6-antagonisten als wirkstoff |
Country Status (18)
| Country | Link |
|---|---|
| EP (3) | EP0783893B1 (de) |
| JP (1) | JP3067987B2 (de) |
| KR (1) | KR100306517B1 (de) |
| CN (2) | CN101601861A (de) |
| AT (1) | ATE552012T1 (de) |
| AU (1) | AU700819B2 (de) |
| CA (1) | CA2201781C (de) |
| CZ (1) | CZ296919B6 (de) |
| DK (1) | DK0783893T3 (de) |
| ES (1) | ES2384222T3 (de) |
| FI (1) | FI120721B (de) |
| HU (1) | HU223602B1 (de) |
| LU (1) | LU92048I2 (de) |
| NO (4) | NO321089B1 (de) |
| PL (1) | PL186506B1 (de) |
| PT (1) | PT783893E (de) |
| RU (1) | RU2147443C1 (de) |
| WO (1) | WO1996011020A1 (de) |
Families Citing this family (87)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK2011514T3 (da) * | 1997-03-21 | 2012-03-26 | Chugai Pharmaceutical Co Ltd | Forebyggende eller terapeutisk middel til sensibiliserede-T-celle-medierede sygdomme omfattende IL-6-antagonist som en aktiv bestanddel |
| PT1004315E (pt) * | 1997-08-15 | 2008-07-09 | Chugai Pharmaceutical Co Ltd | Profilácticos e/ou medicamentos contendo anticorpos neutralizantes anti-receptor de il-6 para reduzir a excreção de proteínas urinárias no lúpus eritematoso sistémico |
| ES2299241T3 (es) | 1998-03-17 | 2008-05-16 | Chugai Seiyaku Kabushiki Kaisha | Preventivos o remedios para enfermedades intestinales inflamatorias que contienen anticuerpos antagonistas del receptor il-6. |
| EP1001028B1 (de) | 1998-04-17 | 2006-05-31 | Suntory Limited | Gen, das für ein protein mit auron-synthetisierender aktivität kodiert. |
| US7320792B2 (en) * | 2000-10-25 | 2008-01-22 | Chugai Seiyaku Kabushiki Kaisha | Preventives or remedies for psoriasis containing as the active ingredient IL-6 antagonist |
| US20050074434A1 (en) * | 2001-02-23 | 2005-04-07 | Tomoaki Hoshino | Remedies for metabolic bone diseases |
| UA80091C2 (en) * | 2001-04-02 | 2007-08-27 | Chugai Pharmaceutical Co Ltd | Remedies for infant chronic arthritis-relating diseases and still's disease which contain an interleukin-6 (il-6) antagonist |
| CN100469793C (zh) * | 2001-04-05 | 2009-03-18 | 株式会社免疫生物研究所 | 抗骨桥蛋白抗体及其用途 |
| DE60334678D1 (de) | 2002-02-14 | 2010-12-09 | Chugai Pharmaceutical Co Ltd | Antikörper enthaltende pharmazeutische lösungen |
| GB2401040A (en) | 2003-04-28 | 2004-11-03 | Chugai Pharmaceutical Co Ltd | Method for treating interleukin-6 related diseases |
| JP2007104901A (ja) * | 2004-01-16 | 2007-04-26 | Astellas Pharma Inc | 関節リウマチ治療薬のスクリーニング法 |
| ES2341461T5 (es) * | 2004-02-11 | 2014-10-29 | Warner-Lambert Company Llc | Procedimientos de tratamiento de la artrosis con anticuerpos ANTI-IL-6 |
| AR048335A1 (es) | 2004-03-24 | 2006-04-19 | Chugai Pharmaceutical Co Ltd | Agentes terapeuticos para trastornos del oido interno que contienen un antagonista de il- 6 como un ingrediente activo |
| RU2293559C2 (ru) * | 2005-03-09 | 2007-02-20 | Лидия Николаевна Долгова | Способ подготовки к любрикантной терапии |
| RU2293560C2 (ru) * | 2005-03-09 | 2007-02-20 | Лидия Николаевна Долгова | Способ лечения хронических гонартритов у больных остеоартрозом |
| CN101198698B (zh) | 2005-03-31 | 2014-03-19 | 中外制药株式会社 | 通过调节多肽缔合制备多肽的方法 |
| PE20061324A1 (es) * | 2005-04-29 | 2007-01-15 | Centocor Inc | Anticuerpos anti-il-6, composiciones, metodos y usos |
| JP5312028B2 (ja) * | 2005-09-28 | 2013-10-09 | サイトス バイオテクノロジー アーゲー | インターロイキン−1コンジュゲート及びその使用 |
| WO2007043641A1 (ja) | 2005-10-14 | 2007-04-19 | Fukuoka University | 膵島移植における移植膵島障害抑制剤 |
| AU2006305119B2 (en) | 2005-10-21 | 2012-12-20 | Chugai Seiyaku Kabushiki Kaisha | Agents for treating cardiopathy |
| AR057582A1 (es) | 2005-11-15 | 2007-12-05 | Nat Hospital Organization | Agentes para suprimir la induccion de linfocitos t citotoxicos |
| CA2637917C (en) | 2006-01-27 | 2015-11-24 | Keio University | Therapeutic agents for diseases involving choroidal neovascularization |
| EP3056568B1 (de) | 2006-03-31 | 2021-09-15 | Chugai Seiyaku Kabushiki Kaisha | Verfahren zur kontrolle der blutpharmakokinetik von antikörpern |
| JP5144499B2 (ja) | 2006-03-31 | 2013-02-13 | 中外製薬株式会社 | 二重特異性抗体を精製するための抗体改変方法 |
| JP5754875B2 (ja) | 2006-04-07 | 2015-07-29 | 国立大学法人大阪大学 | 筋再生促進剤 |
| US8080248B2 (en) | 2006-06-02 | 2011-12-20 | Regeneron Pharmaceuticals, Inc. | Method of treating rheumatoid arthritis with an IL-6R antibody |
| PL2374818T3 (pl) | 2006-06-02 | 2013-05-31 | Regeneron Pharma | Przeciwciała o wysokim powinowactwie przeciw ludzkiemu receptorowi IL 6 |
| EP2064241B1 (de) | 2006-08-03 | 2015-10-07 | Vaccinex, Inc. | Monoklonale anti-il-6-antikörper und deren anwendungen |
| JP2010095445A (ja) * | 2006-12-27 | 2010-04-30 | Tokyo Medical & Dental Univ | Il−6アンタゴニストを有効成分とする炎症性筋疾患治療剤 |
| ES2564392T3 (es) | 2007-01-23 | 2016-03-22 | Shinshu University | Inhibidores de IL-6 para el tratamiento de rechazo crónico |
| AU2008304756B8 (en) | 2007-09-26 | 2015-02-12 | Chugai Seiyaku Kabushiki Kaisha | Anti-IL-6 receptor antibody |
| RU2526512C2 (ru) | 2007-09-26 | 2014-08-20 | Чугаи Сейяку Кабусики Кайся | Модифицированная константная область антитела |
| CN101874042B9 (zh) | 2007-09-26 | 2019-01-01 | 中外制药株式会社 | 利用cdr的氨基酸取代来改变抗体等电点的方法 |
| WO2009072604A1 (ja) | 2007-12-05 | 2009-06-11 | Chugai Seiyaku Kabushiki Kaisha | 抗nr10抗体、およびその利用 |
| CA2721052C (en) | 2008-04-11 | 2023-02-21 | Chugai Seiyaku Kabushiki Kaisha | Antigen-binding molecule capable of binding to two or more antigen molecules repeatedly |
| CN102089326B (zh) | 2008-05-13 | 2014-12-31 | 诺维莫尼公司 | 抗白细胞介素-6/白细胞介素-6受体的抗体及其使用方法 |
| US10717781B2 (en) | 2008-06-05 | 2020-07-21 | National Cancer Center | Neuroinvasion inhibitor |
| US8188235B2 (en) | 2008-06-18 | 2012-05-29 | Pfizer Inc. | Antibodies to IL-6 and their uses |
| TWI440469B (zh) | 2008-09-26 | 2014-06-11 | Chugai Pharmaceutical Co Ltd | Improved antibody molecules |
| JP5717624B2 (ja) | 2009-03-19 | 2015-05-13 | 中外製薬株式会社 | 抗体定常領域改変体 |
| EP2409990A4 (de) | 2009-03-19 | 2013-01-23 | Chugai Pharmaceutical Co Ltd | Variante einer konstanten antikörperregion |
| KR20120024763A (ko) | 2009-05-15 | 2012-03-14 | 추가이 세이야쿠 가부시키가이샤 | 항axl 항체 |
| EP2432480B1 (de) * | 2009-05-18 | 2021-05-05 | The University of Hong Kong | Zusammensetzungen und verfahren zur behandlung entzündlicher arthritis |
| WO2011037158A1 (ja) | 2009-09-24 | 2011-03-31 | 中外製薬株式会社 | 抗体定常領域改変体 |
| JO3417B1 (ar) | 2010-01-08 | 2019-10-20 | Regeneron Pharma | الصيغ المستقرة التي تحتوي على الأجسام المضادة لمضاد مستقبل( interleukin-6 (il-6r |
| TWI505838B (zh) | 2010-01-20 | 2015-11-01 | Chugai Pharmaceutical Co Ltd | Stabilized antibody solution containing |
| WO2011108714A1 (ja) | 2010-03-04 | 2011-09-09 | 中外製薬株式会社 | 抗体定常領域改変体 |
| US20130149302A1 (en) | 2010-05-28 | 2013-06-13 | Chugai Seiyaku Kabushiki Kaisha | Therapeutic agents for pancreatic cancer |
| ES2932398T3 (es) | 2010-05-28 | 2023-01-18 | Chugai Pharmaceutical Co Ltd | Potenciador de la respuesta de las células T antitumorales |
| RU2013126477A (ru) | 2010-11-08 | 2014-12-20 | Дженентек, Инк. | Вводимые подкожно антитела против рецептора il-6 |
| KR101962483B1 (ko) | 2010-11-17 | 2019-03-29 | 추가이 세이야쿠 가부시키가이샤 | 혈액응고 제viii 인자의 기능을 대체하는 기능을 갖는 다중특이성 항원 결합 분자 |
| CN103328632A (zh) | 2010-11-30 | 2013-09-25 | 中外制药株式会社 | 与多分子的抗原重复结合的抗原结合分子 |
| JP4987117B2 (ja) | 2010-12-27 | 2012-07-25 | 中外製薬株式会社 | Il−6アンタゴニストを有効成分として含有する血中mmp−3濃度低下剤 |
| CN112812184A (zh) | 2011-02-25 | 2021-05-18 | 中外制药株式会社 | FcγRIIb特异性Fc抗体 |
| WO2013047748A1 (ja) | 2011-09-30 | 2013-04-04 | 中外製薬株式会社 | 複数の生理活性を有する抗原の消失を促進する抗原結合分子 |
| TW201817745A (zh) | 2011-09-30 | 2018-05-16 | 日商中外製藥股份有限公司 | 具有促進抗原清除之FcRn結合域的治療性抗原結合分子 |
| TWI589299B (zh) | 2011-10-11 | 2017-07-01 | 再生元醫藥公司 | 用於治療類風濕性關節炎之組成物及其使用方法 |
| US20140359902A1 (en) | 2011-12-16 | 2014-12-04 | Synthon Biopharmaceuticals B.V. | EXPRESSION OF SECRETORY IgA ANTIBODIES IN DUCKWEED |
| EP2878305B1 (de) | 2012-05-21 | 2017-07-19 | Korea Research Institute of Bioscience and Biotechnology | Pharmazeutische zusammensetzung zur verwendung zur vorbeugung oder behandlung von stat3-vermittelten erkrankungen mit einem salvia plebeia-r. br.- extrakt oder einem teil davon als wirkstoff |
| US10782290B2 (en) | 2013-06-11 | 2020-09-22 | National Center Of Neurology And Psychiatry | Method for predicting post-therapy prognosis of relapsing-remitting multiple sclerosis (RRMS) patient, and method for determining applicability of novel therapy |
| AU2014325063B2 (en) | 2013-09-27 | 2019-10-31 | Chugai Seiyaku Kabushiki Kaisha | Method for producing polypeptide heteromultimer |
| US9017678B1 (en) | 2014-07-15 | 2015-04-28 | Kymab Limited | Method of treating rheumatoid arthritis using antibody to IL6R |
| MA40764A (fr) | 2014-09-26 | 2017-08-01 | Chugai Pharmaceutical Co Ltd | Agent thérapeutique induisant une cytotoxicité |
| IL278014B2 (en) | 2014-12-19 | 2023-10-01 | Chugai Pharmaceutical Co Ltd | Anti-myostatin antibodies, polypeptides containing variable FC regions and methods of use |
| AR103162A1 (es) | 2014-12-19 | 2017-04-19 | Chugai Pharmaceutical Co Ltd | Anticuerpos anti-c5 y métodos para su uso |
| SG10201907215QA (en) | 2015-02-05 | 2019-09-27 | Chugai Pharmaceutical Co Ltd | Antibodies Comprising An Ion Concentration Dependent Antigen-Binding Domain, Fc Region Variants, Il-8-Binding Antibodies, And Uses Therof |
| BR112017014067B1 (pt) | 2015-02-27 | 2021-01-12 | Chugai Seiyaku Kabushiki Kaisha | usos de um anticorpo receptor de il-6 para no tratamento de doenças relacionadas a il-6 |
| WO2016159213A1 (ja) | 2015-04-01 | 2016-10-06 | 中外製薬株式会社 | ポリペプチド異種多量体の製造方法 |
| US10697883B2 (en) | 2015-05-19 | 2020-06-30 | National Center Of Neurology And Psychiatry | Method for determining application of therapy to multiple sclerosis (MS) patient |
| US11174317B2 (en) | 2015-06-04 | 2021-11-16 | National Center Of Neurology And Psychiatry | Therapeutic agent for mental illness comprising IL-6 inhibitor as active ingredient |
| MX2018005589A (es) | 2015-11-03 | 2018-11-09 | Regeneron Pharma | Composiciones que comprenden anticuerpos contra il6r para el tratamiento de la uveitis y el edema macular, y metodos de uso de las mismas. |
| EP3394098A4 (de) | 2015-12-25 | 2019-11-13 | Chugai Seiyaku Kabushiki Kaisha | Anti-myostatin-antikörper und verfahren zur verwendung |
| BR112018009312A8 (pt) | 2015-12-28 | 2019-02-26 | Chugai Pharmaceutical Co Ltd | método para promover eficiência de purificação de polipeptídeo contendo região de fc |
| US11072666B2 (en) | 2016-03-14 | 2021-07-27 | Chugai Seiyaku Kabushiki Kaisha | Cell injury inducing therapeutic drug for use in cancer therapy |
| SG11201807765PA (en) | 2016-04-28 | 2018-10-30 | Chugai Pharmaceutical Co Ltd | Antibody-containing preparation |
| CN109689099B (zh) | 2016-08-05 | 2023-02-28 | 中外制药株式会社 | 用于预防或治疗il-8相关疾病的组合物 |
| CN108339118A (zh) * | 2017-01-23 | 2018-07-31 | 瑞阳(苏州)生物科技有限公司 | 治疗或预防阻塞性睡眠呼吸暂停的药物组合物 |
| JP7185884B2 (ja) | 2017-05-02 | 2022-12-08 | 国立研究開発法人国立精神・神経医療研究センター | Il-6及び好中球の関連する疾患の治療効果の予測及び判定方法 |
| BR112020004336A2 (pt) | 2017-09-13 | 2020-09-08 | Jiangsu Hengrui Medicine Co., Ltd. | anticorpo il-6r e fragmento de ligação de antígeno do mesmo e uso médico |
| WO2019078344A1 (ja) | 2017-10-20 | 2019-04-25 | 学校法人兵庫医科大学 | 抗il-6受容体抗体を含有する術後の癒着を抑制するための医薬組成物 |
| CR20240273A (es) | 2017-11-01 | 2024-08-27 | Chugai Pharmaceutical Co Ltd | Variantes e isoformas de anticuerpos con actividad biológica reducida (divisional 2020-229) |
| BR112021003206A2 (pt) | 2018-08-29 | 2021-05-25 | Regeneron Pharmaceuticals, Inc. | métodos e composições para tratar indivíduos com artrite reumatoide |
| CN109517064B (zh) * | 2018-10-10 | 2020-05-08 | 北京汇智和源生物技术有限公司 | 白介素-6的人源化单克隆抗体、其编码基因及应用 |
| TWI860325B (zh) | 2019-01-31 | 2024-11-01 | 法商賽諾菲生物技術公司 | 用於治療幼年原發性關節炎之組成物及方法 |
| WO2020178193A1 (en) | 2019-03-01 | 2020-09-10 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Method of treatment of sarcoidosis |
| AU2020261431A1 (en) | 2019-04-24 | 2021-12-09 | Regeneron Pharmaceuticals, Inc. | Methods of diagnosis and treatment of rheumatoid arthritis |
| JP2022534794A (ja) | 2019-06-04 | 2022-08-03 | サノフィ・バイオテクノロジー | 関節リウマチを有する対象における疼痛を治療するための組成物および方法 |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA1341152C (en) | 1988-01-22 | 2000-12-12 | Tadamitsu Kishimoto | Receptor protein for human b cell stimulatory factor-2 |
| EP0399429A1 (de) * | 1989-05-22 | 1990-11-28 | Toray Industries, Inc. | Monoklonaler Antikörper gegen menschliches Interleukin-6 |
| JP2998976B2 (ja) * | 1989-07-20 | 2000-01-17 | 忠三 岸本 | ヒトインタ―ロイキン―6レセプターに対する抗体 |
| JP2898064B2 (ja) | 1989-08-03 | 1999-05-31 | 忠三 岸本 | ヒトgp130蛋白質 |
| DE3939706C1 (de) * | 1989-12-01 | 1991-03-21 | Centre Regional De Transfusion Sanguine, Besancon, Fr | |
| AU648777B2 (en) * | 1989-12-04 | 1994-05-05 | Schering Corporation | Method of treating septic shock |
| JP2898040B2 (ja) | 1990-01-26 | 1999-05-31 | 忠三 岸本 | gp130蛋白質に対する抗体 |
| US5210075A (en) | 1990-02-16 | 1993-05-11 | Tanabe Seiyaku Co., Ltd. | Interleukin 6 antagonist peptides |
| JPH0489433A (ja) | 1990-07-27 | 1992-03-23 | Hitachi Chem Co Ltd | 免疫調節剤 |
| JP2947924B2 (ja) * | 1990-11-21 | 1999-09-13 | 信和化工株式会社 | 光学異性体用分離剤 |
| JPH04187645A (ja) * | 1990-11-22 | 1992-07-06 | Chuzo Kishimoto | インターロイキン―6作用抑制剤 |
| US5795965A (en) * | 1991-04-25 | 1998-08-18 | Chugai Seiyaku Kabushiki Kaisha | Reshaped human to human interleukin-6 receptor |
| JPH05300338A (ja) | 1992-04-17 | 1993-11-12 | Ricoh Co Ltd | 複合機 |
| JPH05304986A (ja) * | 1992-04-28 | 1993-11-19 | Tosoh Corp | gp130蛋白質に対するモノクロ−ナル抗体 |
| FR2694767B1 (fr) * | 1992-08-13 | 1994-10-21 | Innotherapie Lab Sa | Anticorps monoclonaux anti-IL6R, et leurs applications. |
| JPH06134617A (ja) | 1992-10-23 | 1994-05-17 | Amada Co Ltd | 鋸盤の鋸刃テンション自動調整装置 |
| JP3525221B2 (ja) * | 1993-02-17 | 2004-05-10 | 味の素株式会社 | 免疫抑制剤 |
-
1995
- 1995-06-07 EP EP95921130A patent/EP0783893B1/de not_active Expired - Lifetime
- 1995-06-07 WO PCT/JP1995/001144 patent/WO1996011020A1/ja not_active Ceased
- 1995-06-07 CN CNA2009101322726A patent/CN101601861A/zh active Pending
- 1995-06-07 AT AT95921130T patent/ATE552012T1/de active
- 1995-06-07 CN CN2008102100070A patent/CN101361972B/zh not_active Expired - Lifetime
- 1995-06-07 KR KR1019970702209A patent/KR100306517B1/ko not_active Expired - Lifetime
- 1995-06-07 DK DK95921130.1T patent/DK0783893T3/da active
- 1995-06-07 PL PL95319574A patent/PL186506B1/pl unknown
- 1995-06-07 ES ES95921130T patent/ES2384222T3/es not_active Expired - Lifetime
- 1995-06-07 EP EP09009350A patent/EP2107070A1/de not_active Withdrawn
- 1995-06-07 HU HU9701906A patent/HU223602B1/hu active Protection Beyond IP Right Term
- 1995-06-07 CA CA002201781A patent/CA2201781C/en not_active Expired - Lifetime
- 1995-06-07 CZ CZ0103497A patent/CZ296919B6/cs not_active IP Right Cessation
- 1995-06-07 AU AU26303/95A patent/AU700819B2/en not_active Expired
- 1995-06-07 RU RU97108276A patent/RU2147443C1/ru active Protection Beyond IP Right Term
- 1995-06-07 PT PT95921130T patent/PT783893E/pt unknown
- 1995-06-07 EP EP09000787A patent/EP2077120A3/de not_active Withdrawn
- 1995-10-06 JP JP7284364A patent/JP3067987B2/ja not_active Expired - Lifetime
-
1997
- 1997-04-04 FI FI971404A patent/FI120721B/fi not_active IP Right Cessation
- 1997-04-04 NO NO19971546A patent/NO321089B1/no not_active IP Right Cessation
-
2005
- 2005-11-17 NO NO20055446A patent/NO20055446L/no not_active Application Discontinuation
-
2009
- 2009-05-04 NO NO2009009C patent/NO2009009I2/no unknown
-
2012
- 2012-07-20 LU LU92048C patent/LU92048I2/fr unknown
-
2018
- 2018-05-23 NO NO2018017C patent/NO2018017I1/no unknown
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ATE552012T1 (de) | Hemmung des abnormalen wachstums von synovialzellen durch il-6-antagonisten als wirkstoff | |
| RU97108276A (ru) | Лечебные средства против хронического ревматоидного артрита, содержащие антагонист il-6 в качестве эффективного компонента | |
| EA200000868A1 (ru) | Ингибиторы фосфолипаз | |
| TR199801255T2 (xx) | Vitronektin resept�r antagonistleri. | |
| BR9907256A (pt) | Inibidores beta-cetoamida de proteassoma 20s | |
| RU94040174A (ru) | Гетероциклические соединения, способ их получения, фармкомпозиция и способ лечения | |
| ATE232204T1 (de) | Neue sulfonamide | |
| DK0533058T3 (da) | Imidazo-kondenserede iso- og heterocykler som angiotensin-II-antagonister | |
| TR200200082T2 (tr) | MEK inhibitörleri kullanılarak kronik ağrının tedavi edilmesi. | |
| TR199801253T2 (xx) | Vitronektin resept�r� antagonistleri. | |
| NO924326L (no) | Antitrombosemidler | |
| NO932620L (no) | Amindiol-proteaseinhibitorer | |
| ATE387215T1 (de) | Mittel zur prävention oder behandlung von psoriasis mit einem il-6-antagonist als wirkstoff | |
| DE3485895D1 (de) | Verwendung von durch emulgatoren stabilisierte kohlenwasserstoffschlaemme als brennstoffe. | |
| BR9910359A (pt) | Proteìna hìbrida para inibição de desgranulação de mastócitos e seu uso | |
| KR960013371A (ko) | 약학적 혼합물 | |
| EA200000891A1 (ru) | Кристаллическая форма 4-[5-метил-3-фенилизоксазол-4-ил] бензолсульфонамида | |
| AU8330898A (en) | Substituted heterocycles and their use in medicaments | |
| ATE458497T1 (de) | Antagonisten von 'hedgehog' und 'patched' zur inhibierung des wachstums und der differenzierung von zellen und geweben, als auch deren verwendungen | |
| EA200100607A1 (ru) | 3,4,5-тризамещенные арилнитроны и содержащие их фармацевтические композиции | |
| ES2152328T3 (es) | Antagonistas del receptor del fibrinogeno. | |
| DK0636247T3 (da) | Fremgangsmåde og sammensætning til reduktion af virkningerne af endogen alkalisk phosphatase | |
| ES2044100T3 (es) | Ciertas combinaciones de antagonistas del "paf" y antihistaminicos y metodos. | |
| ATE53492T1 (de) | Formulierung von entzuendungshemmenden arzneimitteln. | |
| IT1274022B (it) | Derivati della cumarina ad attivita' farmacologica, loro uso e composizioni farmaceutiche che li contengono |