AR080428A1 - Formulaciones liquidas estabilizadas contentivas de anticuerpos - Google Patents

Formulaciones liquidas estabilizadas contentivas de anticuerpos

Info

Publication number
AR080428A1
AR080428A1 ARP110100185A ARP110100185A AR080428A1 AR 080428 A1 AR080428 A1 AR 080428A1 AR P110100185 A ARP110100185 A AR P110100185A AR P110100185 A ARP110100185 A AR P110100185A AR 080428 A1 AR080428 A1 AR 080428A1
Authority
AR
Argentina
Prior art keywords
formulation according
formulation
antibody
buffer
hydroxymethyl
Prior art date
Application number
ARP110100185A
Other languages
English (en)
Inventor
Tomoyuki Igawa
Chifumi Moriyama
Original Assignee
Chugai Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=44306888&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AR080428(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Chugai Pharmaceutical Co Ltd filed Critical Chugai Pharmaceutical Co Ltd
Publication of AR080428A1 publication Critical patent/AR080428A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39591—Stabilisation, fragmentation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/244—Interleukins [IL]
    • C07K16/248—IL-6
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Dermatology (AREA)
  • Organic Chemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Un objetivo de la presente es proveer formulaciones estables contentivas de anticuerpos que sean adecuadas para la administracion subcutánea en las cuales se haya suprimido la formacion de agregados durante el almacenamiento por largos períodos. Los autores de la presente descubrieron que se logra un efecto estabilizador significativo al usar un amino ácido acídico, ácido aspártico o ácido glutámico como especies contraionicas en buffers de histidina o tris(hidroximetil)aminometano, específicamente usando un buffer de histidina-aspartato o de histidina-glutamato, o tris(hidroximetil)aminometano-aspartato o tris(hidroximetil) aminometano-glutamato como buffer. Reivindicacion 7: La formulacion de acuerdo a cualquiera de las reivindicaciones 1 a la 6 que sustancialmente no comprende ion cloruro e ion acetato. Reivindicacion 8: La formulacion de acuerdo a cualquiera de las reivindicaciones 1 a la 7 que adicionalmente comprende un azucar. Reivindicacion 9: La formulacion de acuerdo a cualquiera de las reivindicaciones 1 a la 8 en la que el anticuerpo es un anticuerpo humanizado o un anticuerpo humano. Reivindicacion 10: La formulacion de acuerdo a cualquiera de las reivindicaciones 1 a la 9 en la que el anticuerpo ha sido modificado para tener un punto isoeléctrico (pI) de 5 a 8. Reivindicacion 12: La formulacion de acuerdo a cualquiera de las reivindicaciones 1 a la 10 en la que la concentracion del anticuerpo es de 50 a 250 mg/ml. Reivindicacion 13: La formulacion de acuerdo a cualquiera de las reivindicaciones 1 a la 12 en la que la formulacion es líquida. Reivindicacion 17: La formulacion de acuerdo a cualquiera de las reivindicaciones 13 a la 16 y que esté congelada entre -30°C y -10°C. Reivindicacion 18: La formulacion de acuerdo a cualquiera de las reivindicaciones 1 a la 12 y que la formulacion sea una formulacion liofilizada. Reivindicacion 21: La formulacion de acuerdo a cualquiera de las reivindicaciones 1 a la 20 en la cual el anticuerpo es un anticuerpo del receptor anti-IL-6. Reivindicacion 22: La formulacion de acuerdo a cualquiera de las reivindicaciones 2, 4, y 7 a la 21 en la cual el buffer comprende sustancialmente solo aminoácidos. Reivindicacion 24: Un método para suprimir la formacion de agregado durante el almacenamiento congelado de una formulacion altamente concentrada contentiva de anticuerpos usando ácido aspártico o ácido glutámico como especie contraionica a un buffer de la formulacion.
ARP110100185A 2010-01-20 2011-01-19 Formulaciones liquidas estabilizadas contentivas de anticuerpos AR080428A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP2010010060 2010-01-20

Publications (1)

Publication Number Publication Date
AR080428A1 true AR080428A1 (es) 2012-04-11

Family

ID=44306888

Family Applications (2)

Application Number Title Priority Date Filing Date
ARP110100185A AR080428A1 (es) 2010-01-20 2011-01-19 Formulaciones liquidas estabilizadas contentivas de anticuerpos
ARP210101446A AR122198A2 (es) 2010-01-20 2021-05-28 Formulaciones líquidas estabilizadas contentivas de anticuerpos

Family Applications After (1)

Application Number Title Priority Date Filing Date
ARP210101446A AR122198A2 (es) 2010-01-20 2021-05-28 Formulaciones líquidas estabilizadas contentivas de anticuerpos

Country Status (22)

Country Link
US (3) US10022319B2 (es)
EP (4) EP2526963B1 (es)
JP (2) JP5939799B2 (es)
KR (5) KR101944211B1 (es)
CN (2) CN105944099B (es)
AR (2) AR080428A1 (es)
AU (5) AU2011208075B2 (es)
BR (1) BR112012018023A2 (es)
CA (2) CA3115615C (es)
DK (1) DK2526963T3 (es)
ES (2) ES2671224T3 (es)
IL (3) IL296486A (es)
MX (1) MX349560B (es)
MY (1) MY185867A (es)
NZ (1) NZ601374A (es)
PL (2) PL3892292T3 (es)
RU (1) RU2653447C2 (es)
SG (2) SG182517A1 (es)
TR (1) TR201807401T4 (es)
TW (2) TWI609698B (es)
WO (1) WO2011090088A1 (es)
ZA (1) ZA201205446B (es)

Families Citing this family (91)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2401040A (en) 2003-04-28 2004-11-03 Chugai Pharmaceutical Co Ltd Method for treating interleukin-6 related diseases
CN101198698B (zh) 2005-03-31 2014-03-19 中外制药株式会社 通过调节多肽缔合制备多肽的方法
EP2009101B1 (en) 2006-03-31 2017-10-25 Chugai Seiyaku Kabushiki Kaisha Antibody modification method for purifying bispecific antibody
CN104761637B (zh) 2006-03-31 2021-10-15 中外制药株式会社 调控抗体血液动力学的方法
CN101874042B9 (zh) 2007-09-26 2019-01-01 中外制药株式会社 利用cdr的氨基酸取代来改变抗体等电点的方法
PE20091174A1 (es) 2007-12-27 2009-08-03 Chugai Pharmaceutical Co Ltd Formulacion liquida con contenido de alta concentracion de anticuerpo
CN104928336B (zh) 2009-10-26 2020-05-08 弗·哈夫曼-拉罗切有限公司 用于生产糖基化免疫球蛋白的方法
AR080428A1 (es) 2010-01-20 2012-04-11 Chugai Pharmaceutical Co Ltd Formulaciones liquidas estabilizadas contentivas de anticuerpos
EP2787007A3 (en) 2010-11-08 2015-03-11 F. Hoffmann-La Roche AG Subcutaneously administered ANTI-IL-6 receptor antibody
KR101962483B1 (ko) 2010-11-17 2019-03-29 추가이 세이야쿠 가부시키가이샤 혈액응고 제viii 인자의 기능을 대체하는 기능을 갖는 다중특이성 항원 결합 분자
WO2013012022A1 (ja) 2011-07-19 2013-01-24 中外製薬株式会社 アルギニンアミドまたはその類似化合物を含む安定なタンパク質含有製剤
KR101993488B1 (ko) 2011-09-01 2019-06-26 추가이 세이야쿠 가부시키가이샤 한외여과에 의해 고도로 농축된 항체를 포함하는 조성물의 제조 방법
AU2012330497B2 (en) * 2012-04-04 2016-08-04 Polaris Group Methods of treating with arginine deiminase
US9969794B2 (en) 2012-05-10 2018-05-15 Visterra, Inc. HA binding agents
JP6224586B2 (ja) * 2012-07-10 2017-11-01 武田薬品工業株式会社 注射用製剤
WO2014054744A1 (ja) * 2012-10-03 2014-04-10 協和発酵キリン株式会社 培養液にアミノ酸を添加することによるポリペプチドの還元防止方法
EP2727602A1 (en) * 2012-10-31 2014-05-07 Takeda GmbH Method for preparation of a high concentration liquid formulation of an antibody
UA117466C2 (uk) 2012-12-13 2018-08-10 Мерк Шарп Енд Доме Корп. СТАБІЛЬНИЙ СКЛАД У ВИГЛЯДІ РОЗЧИНУ АНТИТІЛА ДО IL-23p19
SG11201508829QA (en) 2013-05-30 2015-12-30 Biogen Ma Inc Oncostatin m receptor antigen binding proteins
CN105764922B (zh) 2013-09-27 2020-07-17 中外制药株式会社 多肽异源多聚体的制备方法
BR112016011224A2 (pt) 2013-11-29 2017-09-19 Ares Trading Sa Formulação líquida de uma proteína de fusão que compreende tnfr e região de fc
US10323095B2 (en) 2014-03-17 2019-06-18 Mitsubishi Tanabe Pharma Corporation Antibody-fynomer conjugates
TW201625299A (zh) 2014-06-20 2016-07-16 Chugai Pharmaceutical Co Ltd 用於因第ｖｉｉｉ凝血因子及／或活化的第ｖｉｉｉ凝血因子的活性降低或欠缺而發病及／或進展的疾病之預防及／或治療之醫藥組成物
TWI700300B (zh) 2014-09-26 2020-08-01 日商中外製藥股份有限公司 中和具有第ｖｉｉｉ凝血因子（ｆｖｉｉｉ）機能替代活性的物質之抗體
TWI701435B (zh) 2014-09-26 2020-08-11 日商中外製藥股份有限公司 測定ｆｖｉｉｉ的反應性之方法
KR20170065662A (ko) * 2014-10-18 2017-06-13 화이자 인코포레이티드 항-il-7r 항체 조성물
KR102455905B1 (ko) * 2014-10-30 2022-10-17 추가이 세이야쿠 가부시키가이샤 시린지 캡을 구비한, 침 부착 프리필드 시린지 제제
EP3224359B1 (en) * 2014-11-25 2023-10-25 Bio-Rad Laboratories, Inc. Arginine improves polymerase storage stability
TWI873632B (zh) 2015-02-27 2025-02-21 日商中外製藥股份有限公司 Il-6受體抗體用於製備醫藥組成物的用途
US11142587B2 (en) 2015-04-01 2021-10-12 Chugai Seiyaku Kabushiki Kaisha Method for producing polypeptide hetero-oligomer
WO2017110980A1 (ja) 2015-12-25 2017-06-29 中外製薬株式会社 増強された活性を有する抗体及びその改変方法
SG11201803989WA (en) 2015-12-28 2018-06-28 Chugai Pharmaceutical Co Ltd Method for promoting efficiency of purification of fc region-containing polypeptide
CN108778261A (zh) * 2016-01-12 2018-11-09 雷迪博士实验室有限公司 稳定的药物组合物
MX2018008300A (es) * 2016-01-13 2018-09-21 Genmab As Formulacion para anticuerpo y conjugado de farmaco del mismo.
EP3419663A1 (en) * 2016-02-24 2019-01-02 Visterra, Inc. Formulations of antibody molecules to influenza virus
EP3443346B1 (en) * 2016-04-13 2023-08-30 Medimmune, LLC Use of amino acids as stabilizing compounds in pharmaceutical compositions containing high concentrations of protein-based therapeutic agents
ES3055961T3 (en) * 2016-04-28 2026-02-17 Chugai Pharmaceutical Co Ltd Antibody-containing preparation
CN119950689A (zh) 2016-07-05 2025-05-09 北极星药业集团股份有限公司 使用精氨酸耗竭剂的组合癌症免疫疗法
CN109415444B (zh) 2016-07-29 2024-03-01 中外制药株式会社 显示增加的备选fviii辅因子功能活性的双特异性抗体
EP3509637B1 (en) 2016-09-06 2024-11-27 Chugai Seiyaku Kabushiki Kaisha Methods of using a bispecific antibody that recognizes coagulation factor ix and/or activated coagulation factor ix and coagulation factor x and/or activated coagulation factor x
WO2018085551A2 (en) 2016-11-02 2018-05-11 Polaris Group Formulations of pegylated arginine deiminase
BR112019018022A2 (pt) * 2017-03-01 2020-06-02 Medimmune Limited Formulações de anticorpos monoclonais
JPWO2018179138A1 (ja) * 2017-03-29 2020-02-06 持田製薬株式会社 抗体含有液体製剤
KR102692727B1 (ko) 2017-03-31 2024-08-08 메이지 세이카 파루마 가부시키가이샤 수성 제제 및 주사기 내 수성 제제, 및 항체 단백질 탈응집제 및 항체 단백질 탈응집 방법
EP3603670A4 (en) 2017-03-31 2021-03-10 Public University Corporation Nara Medical University MEDICAL COMPOSITION FOR THE PREVENTION AND / OR TREATMENT OF BLOOD CLOG FACTOR IX ANOMALY WITH A MULTI-SPECIFIC ANTIGIBINDING MOLECULAR FUNCTION OF BLOOD CLOTHING FACTOR VIII
BR112019021364A2 (pt) 2017-04-11 2020-05-05 Kiniksa Phamaceuticals Ltd formulação estável de anticorpo anti-osmr
WO2018200533A1 (en) * 2017-04-28 2018-11-01 Amgen Inc. Excipients to reduce the viscosity of antibody formulations and formulation compositions
RU2019138507A (ru) 2017-05-02 2021-06-02 Мерк Шарп И Доум Корп. Составы антител против lag3 и совместные составы антител против lag3 и антител против pd-1
JOP20190260A1 (ar) 2017-05-02 2019-10-31 Merck Sharp & Dohme صيغ ثابتة لأجسام مضادة لمستقبل الموت المبرمج 1 (pd-1) وطرق استخدامها
JP6496095B1 (ja) 2017-09-29 2019-04-03 中外製薬株式会社 血液凝固第ｖｉｉｉ因子（ｆｖｉｉｉ）補因子機能代替活性を有する多重特異性抗原結合分子および当該分子を有効成分として含有する薬学的製剤
US11692037B2 (en) 2017-10-20 2023-07-04 Hyogo College Of Medicine Anti-IL-6 receptor antibody-containing medicinal composition for preventing post-surgical adhesion
TW202600611A (zh) 2017-11-01 2026-01-01 日商中外製藥股份有限公司 生物活性降低之抗體變異體與同功型
MX2020005630A (es) * 2017-11-30 2020-08-20 Bio Thera Solutions Ltd Formulacion liquida de anticuerpos humanizados para el tratamiento de enfermedades relacionadas con il-6.
WO2019151418A1 (ja) 2018-01-31 2019-08-08 元一 加藤 Ｉｌ－６阻害剤を含有する喘息の治療剤
AU2019254478A1 (en) * 2018-04-16 2020-12-03 Merck Patent Gmbh Method for stabilizing protein comprising formulations by using a meglumine salt.
JP2022500414A (ja) 2018-09-12 2022-01-04 シルバーバック セラピューティックス インコーポレイテッド 免疫刺激性コンジュゲートにより疾患を処置する方法および組成物
CN113056482A (zh) 2018-10-18 2021-06-29 默沙东公司 抗rsv抗体的制剂及其使用方法
CA3117245A1 (en) * 2018-10-31 2020-05-07 Richter Gedeon Nyrt. Aqueous pharmaceutical formulations
CN120842406A (zh) 2018-10-31 2025-10-28 默沙东有限责任公司 抗人pd-1抗体晶体及其使用方法
KR20210089215A (ko) 2018-11-07 2021-07-15 머크 샤프 앤드 돔 코포레이션 항-lag3 항체 및 항-pd-1 항체의 공동-제제
KR102750533B1 (ko) 2019-01-29 2025-01-06 현대자동차 주식회사 엔진 시스템
JPWO2020202839A1 (es) 2019-03-29 2020-10-08
WO2020213665A1 (ja) 2019-04-17 2020-10-22 国立大学法人広島大学 Ｉｌ－６阻害剤及びｃｃｒ２阻害剤を組み合わせて投与することを特徴とする泌尿器がんの治療剤
TW202108171A (zh) * 2019-04-23 2021-03-01 法商賽諾菲公司 穩定的低黏度抗體調配物及其用途
KR20220035908A (ko) 2019-06-19 2022-03-22 실버백 테라퓨틱스, 인크. 항-메소텔린 항체 및 이의 면역접합체
CN112206319B (zh) * 2019-07-12 2025-03-18 鲁南制药集团股份有限公司 一种cd47单克隆抗体制剂及其制备方法
EP3996740A4 (en) * 2019-07-12 2023-07-05 Contrafect Corporation THERAPEUTIC PROTEIN FORMULATIONS INCLUDING ANTIBODIES AND THEIR USES
TWI745114B (zh) 2019-10-11 2021-11-01 日商中外製藥股份有限公司 用於後天性血友病a之預防及/或治療之醫藥組成物、及包含該醫藥組成物之製品
EP3808777A1 (en) 2019-10-16 2021-04-21 Glenmark Specialty S.A. Stable liquid antibody formulations
JP7525254B2 (ja) * 2019-11-14 2024-07-30 ミヨシ油脂株式会社 有機アンモニウム塩とそれを用いた生体試料処理剤
PE20230112A1 (es) * 2020-02-13 2023-01-27 Amgen Inc Formulaciones de anticuerpos anti-tslp humanos y metodos de tratamiento de una enfermedad inflamatoria
WO2021168274A1 (en) 2020-02-21 2021-08-26 Silverback Therapeutics, Inc. Nectin-4 antibody conjugates and uses thereof
AU2021262609A1 (en) 2020-05-01 2022-12-22 Kashiv Biosciences, Llc An improved process of purification of protein
CA3182940A1 (en) * 2020-05-28 2021-12-02 Kashiv Biosciences, Llc An improved process of storing and preparing the protein formulation
TWI872251B (zh) * 2020-05-29 2025-02-11 日商中外製藥股份有限公司 含有抗體製劑
AU2021300362A1 (en) 2020-07-01 2023-02-23 ARS Pharmaceuticals, Inc. Anti-ASGR1 antibody conjugates and uses thereof
US20220042977A1 (en) * 2020-08-04 2022-02-10 ProStabilis, Inc. Protein Solubility Screening Kits and Their Use
EP4199965A4 (en) * 2020-08-19 2025-03-26 Bio-Thera Solutions, Ltd. LIQUID FORMULATIONS CONTAINING HIGHLY CONCENTRATED HUMANIZED ANTIBODIES FOR THE TREATMENT OF IL-6-ASSOCIATED DISEASES
KR20220028972A (ko) * 2020-08-31 2022-03-08 (주)셀트리온 안정한 약제학적 제제
CN112798720B (zh) * 2021-01-11 2022-04-19 苏州药明生物技术有限公司 组氨酸缓冲液在减少蛋白聚体中的应用
CA3211328A1 (en) 2021-03-12 2022-09-15 Takatoshi Ozawa Pharmaceutical composition for treatment or prevention of myasthenia gravis
AU2022271025A1 (en) * 2021-05-07 2023-12-14 Dr. Reddy’S Laboratories Limited A method of improving stability of an antibody formulation
WO2023020563A1 (en) * 2021-08-18 2023-02-23 Bio-Thera Solutions, Ltd. Liquid formulations comprising high concentrations humanized antibodies for treating il-6 related diseases
USD987969S1 (en) * 2022-02-24 2023-06-06 L'atelier De Chaussures, S.L Heel for footwear
WO2023202685A1 (en) * 2022-04-22 2023-10-26 Eirgenix, Inc. Pharmaceutical compositons containing anti-her2 antibody for subcutaneous administration
CN117705549A (zh) * 2022-09-06 2024-03-15 迈克生物股份有限公司 一种蛋白保护剂、稀释液和应用
CN115718192B (zh) * 2022-11-25 2025-02-14 浙江洛兮医疗科技有限公司 一种免疫组化即用型pd-l1抗体试剂
AU2024224961A1 (en) 2023-02-21 2025-09-11 Joint-Stock Company "Generium" Pharmaceutical composition and method for the prophylaxis and treatment of a lysosomal enzyme deficiency in a subject with mucopolysaccharidosis type ii
CN117007791B (zh) * 2023-07-18 2024-08-09 广州市进德生物科技有限公司 一种辣根过氧化物酶偶联物稀释保存液
WO2025198912A1 (en) 2024-03-21 2025-09-25 Hoffmann-La Roche Inc. Methods of treating myasthenia gravis
WO2026011751A1 (zh) * 2024-07-08 2026-01-15 武汉友芝友生物制药股份有限公司 抗体制剂

Family Cites Families (94)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS55102519A (en) 1979-01-31 1980-08-05 Green Cross Corp:The Stabilization of interferon
JPS58201994A (ja) 1982-05-21 1983-11-25 Hideaki Hagiwara 抗原特異的ヒト免疫グロブリンの生産方法
GB8607679D0 (en) 1986-03-27 1986-04-30 Winter G P Recombinant dna product
IT1240314B (it) 1989-09-28 1993-12-07 Immunobiology Research Institutes, Inc. Formulazioni acquose stabilizzate di piccoli peptidi.
GB9015198D0 (en) 1990-07-10 1990-08-29 Brien Caroline J O Binding substance
CA2109602C (en) 1990-07-10 2002-10-01 Gregory P. Winter Methods for producing members of specific binding pairs
AU8507191A (en) 1990-08-29 1992-03-30 Genpharm International, Inc. Transgenic non-human animals capable of producing heterologous antibodies
ES2134212T3 (es) 1991-04-25 1999-10-01 Chugai Pharmaceutical Co Ltd Anticuerpo humano reconstituido contra el receptor de la interleuquina 6 humano.
EP0605522B1 (en) 1991-09-23 1999-06-23 Medical Research Council Methods for the production of humanized antibodies
PT1696031E (pt) 1991-12-02 2010-06-25 Medical Res Council Produção de auto-anticorpos a partir de reportórios de segmentos de anticorpo e exibidos em fagos
AU3328493A (en) 1991-12-17 1993-07-19 Genpharm International, Inc. Transgenic non-human animals capable of producing heterologous antibodies
JP3507073B2 (ja) 1992-03-24 2004-03-15 ケンブリッジ アンティボディー テクノロジー リミティド 特異的結合対の成員の製造方法
ES2301158T3 (es) 1992-07-24 2008-06-16 Amgen Fremont Inc. Produccion de anticuerpos xenogenicos.
AU6819494A (en) 1993-04-26 1994-11-21 Genpharm International, Inc. Transgenic non-human animals capable of producing heterologous antibodies
GB9313509D0 (en) 1993-06-30 1993-08-11 Medical Res Council Chemisynthetic libraries
WO1995015388A1 (en) 1993-12-03 1995-06-08 Medical Research Council Recombinant binding proteins and peptides
CA2194907A1 (en) 1994-07-13 1996-02-01 Kouji Matsushima Reshaped human antibody against human interleukin-8
ATE552012T1 (de) 1994-10-07 2012-04-15 Chugai Pharmaceutical Co Ltd Hemmung des abnormalen wachstums von synovialzellen durch il-6-antagonisten als wirkstoff
PL182089B1 (en) 1994-10-21 2001-11-30 Chugai Pharmaceutical Co Ltd Pharmaceutic compositions for treating diseases caused by production of il-6
EP0822830B1 (en) 1995-04-27 2008-04-02 Amgen Fremont Inc. Human anti-IL-8 antibodies, derived from immunized xenomice
WO1996034096A1 (en) 1995-04-28 1996-10-31 Abgenix, Inc. Human antibodies derived from immunized xenomice
CA2226575C (en) 1995-07-27 2011-10-18 Genentech, Inc. Stabile isotonic lyophilized protein formulation
DE19539574A1 (de) * 1995-10-25 1997-04-30 Boehringer Mannheim Gmbh Zubereitungen und Verfahren zur Stabilisierung biologischer Materialien mittels Trocknungsverfahren ohne Einfrieren
TW518219B (en) 1996-04-26 2003-01-21 Chugai Pharmaceutical Co Ltd Erythropoietin solution preparation
CZ106299A3 (cs) 1996-09-26 1999-08-11 Chugai Seiyaku Kabushiki Kaisha Protilátky proti proteinu příbuznému s lidským parathyroidálním hormonem
UA76934C2 (en) 1996-10-04 2006-10-16 Chugai Pharmaceutical Co Ltd Reconstructed human anti-hm 1.24 antibody, coding dna, vector, host cell, method for production of reconstructed human antibody, pharmaceutical composition and drug for treating myeloma containing reconstructed human anti-hm 1.24 antibody
CN1204147C (zh) 1998-02-25 2005-06-01 利思进药品公司 提高以抗体为基础的融合蛋白的循环半衰期的方法
TR200002885T2 (tr) 1998-04-03 2000-12-21 Chugai Seiyaku Kabushiki Kaisha İnsan doku faktörüne (TF) karşı insanlaştırılmış antikor
JP2000247903A (ja) 1999-03-01 2000-09-12 Chugai Pharmaceut Co Ltd 長期安定化製剤
TWI241345B (en) 2000-03-10 2005-10-11 Chugai Pharmaceutical Co Ltd Apoptosis inducing polypeptide
DE10022092A1 (de) 2000-05-08 2001-11-15 Aventis Behring Gmbh Stabilisiertes Protein-Präparat und Verfahren zu seiner Herstellung
WO2002033072A1 (fr) 2000-10-20 2002-04-25 Chugai Seiyaku Kabushiki Kaisha Anticorps degrade, agoniste de tpo
ES2392073T3 (es) 2001-11-08 2012-12-04 Abbott Biotherapeutics Corp. Formulación farmacéutica líquida estable de anticuerpos IGG
EP3192528A1 (en) 2002-02-14 2017-07-19 Chugai Seiyaku Kabushiki Kaisha Formulation of anti-il6r antibody-containing solutions comprising a sugar as a stabilizer
WO2004007520A2 (en) 2002-07-12 2004-01-22 Medarex, Inc. Methods and compositions for preventing oxidative degradation of proteins
US7217797B2 (en) 2002-10-15 2007-05-15 Pdl Biopharma, Inc. Alteration of FcRn binding affinities or serum half-lives of antibodies by mutagenesis
WO2004035752A2 (en) 2002-10-15 2004-04-29 Protein Design Labs, Inc. ALTERATION OF FcRn BINDING AFFINITIES OR SERUM HALF-LIVES OF ANTIBODIES BY MUTAGENESIS
US20040191243A1 (en) * 2002-12-13 2004-09-30 Bei Chen System and method for stabilizing antibodies with histidine
CA2517310C (en) 2003-02-28 2015-11-24 Chugai Seiyaku Kabushiki Kaisha Stabilized protein-containing formulations comprising a poloxamer
AU2004229335C1 (en) * 2003-04-04 2010-06-17 Genentech, Inc. High concentration antibody and protein formulations
US20050158303A1 (en) 2003-04-04 2005-07-21 Genentech, Inc. Methods of treating IgE-mediated disorders comprising the administration of high concentration anti-IgE antibody formulations
JP4685764B2 (ja) 2003-04-10 2011-05-18 アボット バイオセラピューティクス コーポレイション 変異誘発による抗体のＦｃＲｎ結合親和力又は血清半減期の改変
GB2401040A (en) 2003-04-28 2004-11-03 Chugai Pharmaceutical Co Ltd Method for treating interleukin-6 related diseases
EP2204190A1 (en) 2003-07-15 2010-07-07 Chugai Seiyaku Kabushiki Kaisha IgM production by transformed cells and methods for quantifying said IgM production
MEP31508A (hr) 2003-07-15 2010-10-10 Amgen Inc Humana anti-ngf neutrališuća antitijela kao selektivni ihibitori ngf signalne kaskade
JP4762717B2 (ja) 2003-10-09 2011-08-31 中外製薬株式会社 ＩｇＭ高濃度安定化溶液
WO2005035754A1 (ja) 2003-10-14 2005-04-21 Chugai Seiyaku Kabushiki Kaisha 機能蛋白質を代替する二重特異性抗体
AU2003271174A1 (en) 2003-10-10 2005-04-27 Chugai Seiyaku Kabushiki Kaisha Double specific antibodies substituting for functional protein
RU2554942C2 (ru) 2003-10-17 2015-07-10 Тугаи Сейяку Кабусики Кайся Терапевтический агент для мезотелиомы
EP1712240B1 (en) 2003-12-25 2015-09-09 Kyowa Hakko Kirin Co., Ltd. Stable water-based medicinal preparation containing antibody
DE602005020743D1 (de) 2004-02-11 2010-06-02 Warner Lambert Co Verfahren zur behandlung von osteoarthritis mit anti-il-6 antikörpern
CA2544692C (en) 2004-07-09 2014-04-01 Chugai Seiyaku Kabushiki Kaisha Anti-glypican 3 antibody
JO3000B1 (ar) 2004-10-20 2016-09-05 Genentech Inc مركبات أجسام مضادة .
EA016022B1 (ru) * 2004-12-21 2012-01-30 Сентокор, Инк. Выделенное антитело млекопитающего против il-12 и способ изменения его активности
CA2603264C (en) 2005-04-08 2017-03-21 Chugai Seiyaku Kabushiki Kaisha Antibody substituting for function of blood coagulation factor viii
ES2407468T3 (es) 2005-04-18 2013-06-12 Yeda Research And Development Company Limited Formulaciones de anticuerpos anti-hepatitis B (HBV) estabilizadas
JP5231810B2 (ja) 2005-12-28 2013-07-10 中外製薬株式会社 抗体含有安定化製剤
US20070206584A1 (en) * 2006-01-31 2007-09-06 Fulling Stephen W Systems and methods for providing a dynamic interaction router
CN101426527A (zh) * 2006-02-03 2009-05-06 米迪缪尼有限公司 蛋白质制剂
JP2009525986A (ja) * 2006-02-03 2009-07-16 メディミューン，エルエルシー タンパク質製剤
TW200806317A (en) 2006-03-20 2008-02-01 Wyeth Corp Methods for reducing protein aggregation
EP2009101B1 (en) 2006-03-31 2017-10-25 Chugai Seiyaku Kabushiki Kaisha Antibody modification method for purifying bispecific antibody
CN101460622A (zh) * 2006-03-31 2009-06-17 中外制药株式会社 用于纯化双特异性抗体的抗体修饰方法
CN104761637B (zh) 2006-03-31 2021-10-15 中外制药株式会社 调控抗体血液动力学的方法
US7285876B1 (en) 2006-05-01 2007-10-23 Raytheon Company Regenerative gate drive circuit for power MOSFET
NZ587107A (en) 2006-06-02 2012-05-25 Regeneron Pharma High affinity antibodies to human il-6 receptor
US20080070230A1 (en) 2006-06-12 2008-03-20 Wyeth Methods for reducing or preventing liquid-liquid phase separation in high concentration protein solutions
EP2081553B1 (en) 2006-10-06 2020-08-12 Amgen Inc. Stable antibody formulations
CN101553504A (zh) 2006-12-11 2009-10-07 豪夫迈·罗氏有限公司 Aβ抗体胃肠外制剂
MX2009006594A (es) * 2006-12-21 2009-08-12 Amgen Inc Formulaciones de ph regulado y estables que contienen polipeptidos.
WO2008086395A2 (en) 2007-01-09 2008-07-17 Wyeth Anti-il-13 antibody formulations and uses thereof
GB0700523D0 (en) * 2007-01-11 2007-02-21 Insense Ltd The Stabilisation Of Proteins
MX2009010179A (es) 2007-03-22 2010-03-15 Imclone Llc Formulaciones estables de anticuerpo.
US20100209434A1 (en) * 2007-03-30 2010-08-19 Medimmune, Llc Antibody formulation
GB0707938D0 (en) 2007-04-25 2007-05-30 Univ Strathclyde Precipitation stabilising compositions
WO2009006301A2 (en) 2007-06-29 2009-01-08 Battelle Memorial Institute Protein stabilization
EP3415529B1 (en) 2007-09-26 2020-11-04 Chugai Seiyaku Kabushiki Kaisha Modified antibody constant region
CN101939425B (zh) * 2007-09-26 2014-05-14 中外制药株式会社 抗il-6受体抗体
CN101874042B9 (zh) 2007-09-26 2019-01-01 中外制药株式会社 利用cdr的氨基酸取代来改变抗体等电点的方法
BRPI0821110B8 (pt) 2007-12-05 2021-05-25 Chugai Pharmaceutical Co Ltd anticorpo de neutralização de anti-nr10/il31ra, composição farmacêutica compreendendo o referido anticorpo e uso do mesmo
WO2009086400A2 (en) * 2007-12-28 2009-07-09 Baxter International Inc. Recombinant vwf formulations
EP2275443B1 (en) 2008-04-11 2015-12-02 Chugai Seiyaku Kabushiki Kaisha Antigen-binding molecule capable of binding to two or more antigen molecules repeatedly
WO2009141239A1 (en) 2008-05-20 2009-11-26 F. Hoffmann-La Roche Ag A pharmaceutical formulation comprising an antibody against ox40l, uses thereof
WO2010106812A1 (en) 2009-03-19 2010-09-23 Chugai Seiyaku Kabushiki Kaisha Pharmaceutical formulation containing improved antibody molecules
EP2522724B1 (en) 2009-12-25 2020-02-05 Chugai Seiyaku Kabushiki Kaisha Polypeptide modification method for purifying polypeptide multimers
AR080428A1 (es) 2010-01-20 2012-04-11 Chugai Pharmaceutical Co Ltd Formulaciones liquidas estabilizadas contentivas de anticuerpos
KR101962483B1 (ko) 2010-11-17 2019-03-29 추가이 세이야쿠 가부시키가이샤 혈액응고 제viii 인자의 기능을 대체하는 기능을 갖는 다중특이성 항원 결합 분자
TW201625299A (zh) 2014-06-20 2016-07-16 Chugai Pharmaceutical Co Ltd 用於因第ｖｉｉｉ凝血因子及／或活化的第ｖｉｉｉ凝血因子的活性降低或欠缺而發病及／或進展的疾病之預防及／或治療之醫藥組成物
WO2017110980A1 (ja) 2015-12-25 2017-06-29 中外製薬株式会社 増強された活性を有する抗体及びその改変方法
ES3055961T3 (en) 2016-04-28 2026-02-17 Chugai Pharmaceutical Co Ltd Antibody-containing preparation
CN109415444B (zh) 2016-07-29 2024-03-01 中外制药株式会社 显示增加的备选fviii辅因子功能活性的双特异性抗体
EP3509637B1 (en) 2016-09-06 2024-11-27 Chugai Seiyaku Kabushiki Kaisha Methods of using a bispecific antibody that recognizes coagulation factor ix and/or activated coagulation factor ix and coagulation factor x and/or activated coagulation factor x
EP3603670A4 (en) 2017-03-31 2021-03-10 Public University Corporation Nara Medical University MEDICAL COMPOSITION FOR THE PREVENTION AND / OR TREATMENT OF BLOOD CLOG FACTOR IX ANOMALY WITH A MULTI-SPECIFIC ANTIGIBINDING MOLECULAR FUNCTION OF BLOOD CLOTHING FACTOR VIII
TW202600611A (zh) 2017-11-01 2026-01-01 日商中外製藥股份有限公司 生物活性降低之抗體變異體與同功型

Also Published As

Publication number Publication date
TR201807401T4 (tr) 2018-06-21
RU2653447C2 (ru) 2018-05-08
ES2671224T3 (es) 2018-06-05
KR102391571B1 (ko) 2022-04-27
SG10202003196SA (en) 2020-05-28
IL296486A (en) 2022-11-01
EP2526963A4 (en) 2015-01-28
CA2786981C (en) 2021-06-08
AU2021245178B2 (en) 2024-10-31
PL3892292T3 (pl) 2024-10-07
CN105944099B (zh) 2021-06-04
EP4442277B1 (en) 2026-04-22
US20230277442A1 (en) 2023-09-07
KR20200062393A (ko) 2020-06-03
TWI609698B (zh) 2018-01-01
JP2016117756A (ja) 2016-06-30
EP3378486B1 (en) 2021-03-03
IL265501B2 (en) 2023-02-01
KR20120117862A (ko) 2012-10-24
EP2526963B1 (en) 2018-04-25
US20180344630A1 (en) 2018-12-06
CN102858366A (zh) 2013-01-02
EP4442277A2 (en) 2024-10-09
EP3378486A2 (en) 2018-09-26
AU2021245178A1 (en) 2021-11-04
CA3115615A1 (en) 2011-07-28
EP3892292B1 (en) 2024-07-24
US20130022625A1 (en) 2013-01-24
PL2526963T3 (pl) 2018-10-31
TW201600112A (zh) 2016-01-01
EP4442277A3 (en) 2024-10-23
KR101944211B1 (ko) 2019-01-30
IL265501A (en) 2019-05-30
CN105944099A (zh) 2016-09-21
BR112012018023A2 (pt) 2017-06-20
EP2526963A1 (en) 2012-11-28
AU2016204729A1 (en) 2016-07-28
KR20220054725A (ko) 2022-05-03
KR20180000339A (ko) 2018-01-02
WO2011090088A1 (ja) 2011-07-28
KR102729982B1 (ko) 2024-11-13
RU2012135384A (ru) 2014-02-27
AR122198A2 (es) 2022-08-24
AU2018202013A1 (en) 2018-04-12
MY185867A (en) 2021-06-14
IL220934B (en) 2021-06-30
EP3892292A2 (en) 2021-10-13
CN102858366B (zh) 2016-11-09
AU2011208075B2 (en) 2016-07-21
AU2020200395A1 (en) 2020-02-13
NZ601374A (en) 2014-07-25
JP5939799B2 (ja) 2016-06-22
TWI505838B (zh) 2015-11-01
MX2012008225A (es) 2012-08-17
EP3378486A3 (en) 2018-12-05
MX349560B (es) 2017-08-03
TW201138828A (en) 2011-11-16
AU2020200395B2 (en) 2021-07-08
CA3115615C (en) 2023-11-07
EP3892292A3 (en) 2021-12-29
US11612562B2 (en) 2023-03-28
DK2526963T3 (en) 2018-06-06
IL265501B (en) 2022-10-01
JPWO2011090088A1 (ja) 2013-05-23
SG182517A1 (en) 2012-08-30
ES2985395T3 (es) 2024-11-05
JP6265563B2 (ja) 2018-01-24
CA2786981A1 (en) 2011-07-28
US10022319B2 (en) 2018-07-17
AU2011208075A1 (en) 2012-08-16
KR20190011326A (ko) 2019-02-01
ZA201205446B (en) 2013-04-24

Similar Documents

Publication Publication Date Title
RU2012135384A (ru) Стабилизированные содержащие антитела жидкие композиции
AR089787A1 (es) Formulaciones estabilizadas que contienen anticuerpos anti-ang2
PE20141413A1 (es) Formulaciones de anticuerpo y metodos
AR083034A1 (es) ESTABILIZACION DE INMUNOGLOBULINAS Y OTRAS PROTEINAS MEDIANTE UNA FORMULACION ACUOSA CON CLORURO DE SODIO A pH ACIDO DEBIL A NEUTRO
AR092400A1 (es) Formulaciones de anticuerpos y proteinas de alta concentracion
NZ601114A (en) Stabilized formulations containing anti-interleukin-6 receptor (il-6r) antibodies
EA201790989A1 (ru) Стабильный препарат раствора белка, содержащего анти-vegf антитело в высокой концентрации
PE20190469A1 (es) Formulaciones, kits y metodos de anticuerpos inhibidores de masp-2 de baja viscosidad altamente concentrados
NZ719036A (en) Anti-pdl1 antibody formulations
PE20141029A1 (es) Composiciones relacionadas con una toxina de clostridium difficile mutante y sus metodos
NZ705178A (en) Anti-prolactin receptor antibody formulations
PE20142167A1 (es) Anticuerpos anti-lgr5 e inmunoconjugados
BR112014023792A2 (pt) proteínas nutritivas carregadas e métodos
PE20141151A1 (es) Proteinas de union al antigeno cd27l
NZ629261A (en) Pharmaceutical formulations of tnf-alpha antibodies
AR082171A1 (es) Formulaciones estabilizadas que contienen anticuerpos anti-ngf
MX2012010114A (es) Formulaciones concentradas de proteina y usos de las mismas.
PE20130579A1 (es) Composiciones y metodos para suministro al sistema nervioso central de iduronato-2-sulfatasa
BR112014001712A2 (pt) formulações estabilizadas contendo anticorpos anti-pcsk9
HK1206370A1 (en) Charged nutritive proteins and methods
EA201391632A1 (ru) Аминокислотные последовательности, направленные против il-17a, il-17f и/или il-17a/f, и содержащие их полипептиды
EP4606820A3 (en) Optimized ratios of amino acids and sugars as amorphous stabilizing compounds in pharmaceutical compositions containing high concentrations of protein-based therapeutic agents
AR095496A1 (es) Formulaciones de anticuerpos anti-receptor de prolactina
RU2014124143A (ru) Стабильная композиция антитела, специфически связывающегося с her2 рецепторами, и способ ее получения
EA201500783A1 (ru) Способы получения дикетопиперазинов и соединений, содержащих дикетопиперазины

Legal Events

Date Code Title Description
FC Refusal