BRPI0515858A - anticorpos anti-il-12, epìtopos, composições, métodos e usos - Google Patents

anticorpos anti-il-12, epìtopos, composições, métodos e usos

Info

Publication number
BRPI0515858A
BRPI0515858A BRPI0515858-3A BRPI0515858A BRPI0515858A BR PI0515858 A BRPI0515858 A BR PI0515858A BR PI0515858 A BRPI0515858 A BR PI0515858A BR PI0515858 A BRPI0515858 A BR PI0515858A
Authority
BR
Brazil
Prior art keywords
methods
compositions
antibodies
epitopes
amino acid
Prior art date
Application number
BRPI0515858-3A
Other languages
English (en)
Inventor
Jill Giles-Komar
George Heavner
David Knight
Jinquan Luo
David Peritt
Bernard Scallon
David Shealy
Original Assignee
Centocor Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Centocor Inc filed Critical Centocor Inc
Publication of BRPI0515858A publication Critical patent/BRPI0515858A/pt

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/244—Interleukins [IL]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
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    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/5434—IL-12
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
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    • C—CHEMISTRY; METALLURGY
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    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
    • C07K2317/14—Specific host cells or culture conditions, e.g. components, pH or temperature
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
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    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding

Abstract

"ANTICORPOS ANTI-IL-12, EPìTOPOS, COMPOSIçõES, MéTODOS E USOS". Anticorpo anti-IL-12 que liga-se a uma porção da proteína de IL-12 correspondente a pelo menos um resíduo de aminoácido selecionado do grupo consistindo nos resíduos 15,17-21,23,40-43, 45-47, 54-56 e 58-62 da seqüencia de aminoácido da subunidade p40 da IL-12, incluindo os ácidos nucléicos isolados que codificam pelo menos um anticorpo anti-IL-12, vetores, células hospedeiras, animais transgênicos ou plantas, e métodos de preparação e emprego destes, tem aplicações em composições, métodos e dispositivos diagnósticos e/ou terapêuticos.
BRPI0515858-3A 2004-12-21 2005-12-20 anticorpos anti-il-12, epìtopos, composições, métodos e usos BRPI0515858A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US63781904P 2004-12-21 2004-12-21
PCT/US2005/046063 WO2006069036A2 (en) 2004-12-21 2005-12-20 Anti-il-12 antibodies, epitopes, compositions, methods and uses

Publications (1)

Publication Number Publication Date
BRPI0515858A true BRPI0515858A (pt) 2008-08-12

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ID=36602254

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0515858-3A BRPI0515858A (pt) 2004-12-21 2005-12-20 anticorpos anti-il-12, epìtopos, composições, métodos e usos

Country Status (22)

Country Link
US (8) US8080247B2 (pt)
EP (1) EP1836294A4 (pt)
JP (1) JP2008523842A (pt)
KR (1) KR20070094927A (pt)
CN (1) CN101120087A (pt)
AR (1) AR051805A1 (pt)
AU (1) AU2005319278A1 (pt)
BR (1) BRPI0515858A (pt)
CA (1) CA2591813A1 (pt)
CR (1) CR9265A (pt)
EA (1) EA016022B1 (pt)
IL (1) IL183939A0 (pt)
MY (1) MY157915A (pt)
NI (1) NI200700155A (pt)
NO (1) NO20073778L (pt)
NZ (2) NZ555658A (pt)
PE (1) PE20061115A1 (pt)
SG (1) SG158150A1 (pt)
TW (1) TWI406943B (pt)
UY (1) UY29291A1 (pt)
WO (1) WO2006069036A2 (pt)
ZA (1) ZA200706036B (pt)

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US7736650B2 (en) * 2004-12-21 2010-06-15 Centocor, Inc. Anti-IL-12 antibody based vectors, host cells, and methods of production and uses
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HUE027165T2 (en) * 2006-10-02 2016-08-29 Squibb & Sons Llc Human antibodies that bind to CXCR4 and their uses
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