MX2010001488A - Composiciones y metodos para cristalizar anticuerpos. - Google Patents
Composiciones y metodos para cristalizar anticuerpos.Info
- Publication number
- MX2010001488A MX2010001488A MX2010001488A MX2010001488A MX2010001488A MX 2010001488 A MX2010001488 A MX 2010001488A MX 2010001488 A MX2010001488 A MX 2010001488A MX 2010001488 A MX2010001488 A MX 2010001488A MX 2010001488 A MX2010001488 A MX 2010001488A
- Authority
- MX
- Mexico
- Prior art keywords
- compositions
- crystals
- methods
- antibody
- crystallizing
- Prior art date
Links
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
- C07K16/241—Tumor Necrosis Factors
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- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/30—Extraction; Separation; Purification by precipitation
- C07K1/306—Extraction; Separation; Purification by precipitation by crystallization
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- C30—CRYSTAL GROWTH
- C30B—SINGLE-CRYSTAL GROWTH; UNIDIRECTIONAL SOLIDIFICATION OF EUTECTIC MATERIAL OR UNIDIRECTIONAL DEMIXING OF EUTECTOID MATERIAL; REFINING BY ZONE-MELTING OF MATERIAL; PRODUCTION OF A HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; SINGLE CRYSTALS OR HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; AFTER-TREATMENT OF SINGLE CRYSTALS OR A HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; APPARATUS THEREFOR
- C30B29/00—Single crystals or homogeneous polycrystalline material with defined structure characterised by the material or by their shape
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- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
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- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
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- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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- Dermatology (AREA)
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- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
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- Orthopedic Medicine & Surgery (AREA)
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- Crystallography & Structural Chemistry (AREA)
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- Heart & Thoracic Surgery (AREA)
Abstract
La presente invención se refiere a un método de cristalización por lotes, para cristalizar un anticuerpo y fragmentos de anticuerpo TNFalfa anti-humano (hTNFalfa), el cual permite la producción del anticuerpo en una escala industrial; a un método para controlar el tamaño de los cristales del anticuerpo. Por ejemplo, cristales de fragmentos de anticuerpo anti-hTNFalfa, a composiciones que contienen dichos cristales, así como a métodos de uso de dichos cristales y composiciones.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US96396407P | 2007-08-08 | 2007-08-08 | |
PCT/US2008/009549 WO2009020654A1 (en) | 2007-08-08 | 2008-08-08 | Compositions and methods for crystallizing antibodies |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2010001488A true MX2010001488A (es) | 2010-03-01 |
Family
ID=40341606
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2010001488A MX2010001488A (es) | 2007-08-08 | 2008-08-08 | Composiciones y metodos para cristalizar anticuerpos. |
Country Status (9)
Country | Link |
---|---|
US (2) | US8753839B2 (es) |
EP (1) | EP2185201A4 (es) |
JP (1) | JP2010535771A (es) |
CN (1) | CN101980722A (es) |
CA (1) | CA2697163A1 (es) |
MX (1) | MX2010001488A (es) |
RU (1) | RU2010107994A (es) |
SG (1) | SG183709A1 (es) |
WO (1) | WO2009020654A1 (es) |
Families Citing this family (76)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6090382A (en) | 1996-02-09 | 2000-07-18 | Basf Aktiengesellschaft | Human antibodies that bind human TNFα |
NZ576716A (en) * | 1996-02-09 | 2011-02-25 | Abbott Biotech Ltd | Human antibodies that bind human TNFalpha |
CA2817619A1 (en) | 2001-06-08 | 2002-12-08 | Abbott Laboratories (Bermuda) Ltd. | Methods of administering anti-tnf.alpha. antibodies |
US20090280065A1 (en) * | 2006-04-10 | 2009-11-12 | Willian Mary K | Uses and Compositions for Treatment of Psoriasis |
NZ563452A (en) * | 2002-07-19 | 2010-04-30 | Abbott Biotech Ltd | Treatment of TNFalpha related disorders |
US20040033228A1 (en) | 2002-08-16 | 2004-02-19 | Hans-Juergen Krause | Formulation of human antibodies for treating TNF-alpha associated disorders |
TWI556829B (zh) | 2004-04-09 | 2016-11-11 | 艾伯維生物技術有限責任公司 | 用於治療TNFα相關失調症之多重可變劑量療法 |
GB0414054D0 (en) | 2004-06-23 | 2004-07-28 | Owen Mumford Ltd | Improvements relating to automatic injection devices |
US20060083741A1 (en) * | 2004-10-08 | 2006-04-20 | Hoffman Rebecca S | Treatment of respiratory syncytial virus (RSV) infection |
JP5757495B2 (ja) | 2005-05-16 | 2015-07-29 | アッヴィ バイオテクノロジー リミテッド | びらん性多発性関節炎の治療のためのtnf阻害剤の使用 |
PL1948235T3 (pl) | 2005-11-01 | 2014-01-31 | Abbvie Biotechnology Ltd | Sposób określania skuteczności adalimumabu u pacjentów cierpiących na zesztywniające zapalenie stawów kręgosłupa z zastosowaniem CTX-II i MMP-3 jako markerów biologicznych |
EP2738178A1 (en) | 2006-04-05 | 2014-06-04 | AbbVie Biotechnology Ltd | Antibody purification |
US20090317399A1 (en) * | 2006-04-10 | 2009-12-24 | Pollack Paul F | Uses and compositions for treatment of CROHN'S disease |
US9605064B2 (en) * | 2006-04-10 | 2017-03-28 | Abbvie Biotechnology Ltd | Methods and compositions for treatment of skin disorders |
EP2007426A4 (en) | 2006-04-10 | 2010-06-16 | Abbott Biotech Ltd | COMPOSITIONS FOR THE TREATMENT OF PSORIASTIC POLYARTHRITIS AND THEIR APPLICATIONS |
US20080118496A1 (en) * | 2006-04-10 | 2008-05-22 | Medich John R | Uses and compositions for treatment of juvenile rheumatoid arthritis |
EP2012586A4 (en) | 2006-04-10 | 2010-08-18 | Abbott Biotech Ltd | USES AND COMPOSITIONS FOR THE TREATMENT OF ANKYLOSANTE SPONDYLARTHRITIS |
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- 2008-08-08 EP EP08795162A patent/EP2185201A4/en not_active Withdrawn
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SG183709A1 (en) | 2012-09-27 |
CN101980722A (zh) | 2011-02-23 |
EP2185201A1 (en) | 2010-05-19 |
EP2185201A4 (en) | 2011-11-30 |
US20150166648A1 (en) | 2015-06-18 |
JP2010535771A (ja) | 2010-11-25 |
US20090148513A1 (en) | 2009-06-11 |
WO2009020654A1 (en) | 2009-02-12 |
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