NO924326L - Antitrombosemidler - Google Patents

Antitrombosemidler

Info

Publication number
NO924326L
NO924326L NO92924326A NO924326A NO924326L NO 924326 L NO924326 L NO 924326L NO 92924326 A NO92924326 A NO 92924326A NO 924326 A NO924326 A NO 924326A NO 924326 L NO924326 L NO 924326L
Authority
NO
Norway
Prior art keywords
inhibitors
antitrombosemidler
alkylalkanoyl
methylphenylglycine
phenylglycyl
Prior art date
Application number
NO92924326A
Other languages
English (en)
Other versions
NO924326D0 (no
Inventor
Robert Theodore Shuman
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of NO924326D0 publication Critical patent/NO924326D0/no
Publication of NO924326L publication Critical patent/NO924326L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/04—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Thrombinlnhibitorer representert ved formel NH II AC (O)¿N--------L-CfO-NH-CI-HCHjVNH-C -NH2 CHO er beskrevet. A er for eksempel fenylglycyl, og fenylalanyl, a-metylfenylalanin og a-metylfenylglycin hvori amlnogruppe fortrinnsvis er substituert med lavere alkylalkanoyl eller lavere alkoksykarbonyl, eller en bisyklogruppe for eksempel l ,2,3, 4-tetrahydro- isoquinolin-1-yl. Det er også tilveiebragt en frem- gangsmåte for inhibering av koageldannelse i mennesker og dyr, farmasøytiske formuleringer som er nyttige i fremgangsmåten og mellomprodukter for inhibitorene.
NO92924326A 1991-11-12 1992-11-10 Antitrombosemidler NO924326L (no)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US79088591A 1991-11-12 1991-11-12

Publications (2)

Publication Number Publication Date
NO924326D0 NO924326D0 (no) 1992-11-10
NO924326L true NO924326L (no) 1993-05-14

Family

ID=25152024

Family Applications (1)

Application Number Title Priority Date Filing Date
NO92924326A NO924326L (no) 1991-11-12 1992-11-10 Antitrombosemidler

Country Status (19)

Country Link
EP (1) EP0542525B1 (no)
JP (1) JP3159806B2 (no)
KR (1) KR930009993A (no)
CN (1) CN1074438A (no)
AU (2) AU646767B2 (no)
BR (1) BR9204361A (no)
CA (1) CA2082748A1 (no)
CZ (1) CZ333492A3 (no)
DE (1) DE69226152T2 (no)
ES (1) ES2120993T3 (no)
FI (1) FI925124A (no)
HU (1) HUT65858A (no)
IL (1) IL103692A0 (no)
MX (1) MX9206474A (no)
NO (1) NO924326L (no)
NZ (1) NZ245039A (no)
TW (1) TW232686B (no)
YU (1) YU97292A (no)
ZA (1) ZA928581B (no)

Families Citing this family (48)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE9103612D0 (sv) * 1991-12-04 1991-12-04 Astra Ab New peptide derivatives
US5783563A (en) * 1993-06-03 1998-07-21 Astra Aktiebolag Method for treatment or prophylaxis of venous thrombosis
US6984627B1 (en) 1993-06-03 2006-01-10 Astrazeneca Ab Peptide derivatives
SE9301916D0 (sv) * 1993-06-03 1993-06-03 Ab Astra New peptides derivatives
US5488037A (en) * 1994-03-04 1996-01-30 Eli Lilly And Company Antithrombotic agents
ZA951618B (en) * 1994-03-04 1996-08-27 Lilly Co Eli Antithrombotic agents
US5436229A (en) * 1994-03-04 1995-07-25 Eli Lilly And Company Bisulfite adducts of arginine aldehydes
US5602101A (en) * 1994-03-04 1997-02-11 Eli Lilly And Company Antithrombotic agents
ZA951617B (en) * 1994-03-04 1997-02-27 Lilly Co Eli Antithrombotic agents.
US5484772A (en) * 1994-03-04 1996-01-16 Eli Lilly And Company Antithrombotic agents
US5726159A (en) * 1994-03-04 1998-03-10 Eli Lilly And Company Antithrombotic agents
US5705487A (en) * 1994-03-04 1998-01-06 Eli Lilly And Company Antithrombotic agents
US5707966A (en) * 1994-03-04 1998-01-13 Eli Lilly And Company Antithrombotic agents
US5885967A (en) * 1994-03-04 1999-03-23 Eli Lilly And Company Antithrombotic agents
CA2143533A1 (en) * 1994-03-04 1995-09-05 Kenneth D. Kurz Antithrombotic agents
US5439888A (en) * 1994-03-04 1995-08-08 Eli Lilly And Company Antithrombotic agents
JPH09509943A (ja) * 1994-03-04 1997-10-07 イーライ・リリー・アンド・カンパニー 抗血栓剤
DE4421052A1 (de) 1994-06-17 1995-12-21 Basf Ag Neue Thrombininhibitoren, ihre Herstellung und Verwendung
SE9404196D0 (sv) * 1994-12-02 1994-12-02 Astra Ab New antithrombotic formulation
SK104697A3 (en) * 1995-02-17 1998-11-04 Basf Ag Novel dipeptide amidines as thrombin inhibitors
US5710130A (en) * 1995-02-27 1998-01-20 Eli Lilly And Company Antithrombotic agents
US5914319A (en) * 1995-02-27 1999-06-22 Eli Lilly And Company Antithrombotic agents
SA96170106A (ar) * 1995-07-06 2005-12-03 أسترا أكتيبولاج مشتقات حامض أميني جديدة
AR005245A1 (es) 1995-12-21 1999-04-28 Astrazeneca Ab Prodrogas de inhibidores de trombina, una formulación farmaceutica que las comprende, el uso de dichas prodrogas para la manufactura de un medicamento y un procedimiento para su preparacion
SE9602263D0 (sv) 1996-06-07 1996-06-07 Astra Ab New amino acid derivatives
SE9602646D0 (sv) 1996-07-04 1996-07-04 Astra Ab Pharmaceutically-useful compounds
AU7292398A (en) 1997-05-15 1998-12-08 Eli Lilly And Company Antithrombotic compound
AR013084A1 (es) 1997-06-19 2000-12-13 Astrazeneca Ab Derivados de amidino utiles como inhibidores de la trombina, composicion farmaceutica, utilizacion de dichos compuestos para la preparacion demedicamentos y proceso para la preparacion de los compuestos mencionados
SE9704543D0 (sv) 1997-12-05 1997-12-05 Astra Ab New compounds
HUP0100082A3 (en) 1998-01-26 2001-12-28 Abbott Gmbh & Co Kg Thrombin inhibitor, peptide derivatives, pharmaceutical compositions comprising thereof and their use
SE9804313D0 (sv) 1998-12-14 1998-12-14 Astra Ab New compounds
TR200102037T2 (tr) 1999-01-13 2001-10-22 Astrazeneca Ab Yeni amidinobenzilamin türevleri ve trombin engelleyiciler olarak kullanılmaları.
AR023510A1 (es) 1999-04-21 2002-09-04 Astrazeneca Ab Un equipo de partes, formulacion farmaceutica y uso de un inhibidor de trombina.
WO2001079208A1 (fr) * 2000-04-19 2001-10-25 Kaneka Corporation Nouveau derive d'azetidine et procede de preparation de celui-ci
SE0001803D0 (sv) 2000-05-16 2000-05-16 Astrazeneca Ab New compounds i
US6433186B1 (en) 2000-08-16 2002-08-13 Astrazeneca Ab Amidino derivatives and their use as thormbin inhibitors
US7129233B2 (en) 2000-12-01 2006-10-31 Astrazeneca Ab Mandelic acid derivatives and their use as thrombin inhibitors
AR035216A1 (es) 2000-12-01 2004-05-05 Astrazeneca Ab Derivados de acido mandelico ,derivados farmaceuticamente aceptables, uso de estos derivados para la fabricacion de medicamentos, metodos de tratamiento ,procesos para la preparacion de estos derivados, y compuestos intermediarios
AR034517A1 (es) 2001-06-21 2004-02-25 Astrazeneca Ab Formulacion farmaceutica
SE0201661D0 (sv) 2002-05-31 2002-05-31 Astrazeneca Ab New salts
SE0201659D0 (sv) 2002-05-31 2002-05-31 Astrazeneca Ab Modified release pharmaceutical formulation
US7781424B2 (en) 2003-05-27 2010-08-24 Astrazeneca Ab Modified release pharmaceutical formulation
US7795205B2 (en) 2004-04-12 2010-09-14 Canyon Pharmaceuticals, Inc. Methods for effecting regression of tumor mass and size in a metastasized pancreatic tumor
RU2008139428A (ru) * 2006-03-06 2010-05-20 Хьюмэджин, Инк. (Us) Способ получения рекомбинантного тромбина и фибриногена человека
CN101190895B (zh) * 2006-11-30 2010-05-26 首都医科大学 N-[(3s)-1,2,3,4-四氢异喹啉-3-甲酰基]氨基酸、其制备方法及应用
TW200827336A (en) 2006-12-06 2008-07-01 Astrazeneca Ab New crystalline forms
CN101318933B (zh) * 2007-06-04 2010-08-11 北京大学 具有抗血栓活性的异喹啉化合物、其制备方法及应用
CN102127097A (zh) * 2010-01-15 2011-07-20 首都医科大学 N-（3s-1,2,3,4-四氢异喹啉-3-甲酰基）氨基酸铜络合物及其制备方法和应用

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4318904A (en) * 1980-04-25 1982-03-09 Research Corporation Peptide affinity labels for thrombin and other trypsin-like proteases
HU192646B (en) * 1984-12-21 1987-06-29 Gyogyszerkutato Intezet Process for preparing new n-alkyl-peptide aldehydes
SE9102462D0 (sv) * 1991-08-28 1991-08-28 Astra Ab New isosteric peptides

Also Published As

Publication number Publication date
DE69226152D1 (de) 1998-08-13
AU2831292A (en) 1993-05-13
EP0542525A3 (en) 1994-06-29
JP3159806B2 (ja) 2001-04-23
CN1074438A (zh) 1993-07-21
ZA928581B (en) 1994-05-06
AU2829892A (en) 1993-05-13
HU9203545D0 (en) 1993-01-28
HUT65858A (en) 1994-07-28
TW232686B (no) 1994-10-21
KR930009993A (ko) 1993-06-21
ES2120993T3 (es) 1998-11-16
BR9204361A (pt) 1993-06-01
DE69226152T2 (de) 1998-12-10
EP0542525B1 (en) 1998-07-08
CZ333492A3 (en) 1993-09-15
NZ245039A (en) 1994-12-22
YU97292A (sh) 1995-10-24
CA2082748A1 (en) 1993-05-13
MX9206474A (es) 1993-10-01
NO924326D0 (no) 1992-11-10
EP0542525A2 (en) 1993-05-19
FI925124A0 (fi) 1992-11-11
AU646767B2 (en) 1994-03-03
FI925124A (fi) 1993-05-13
JPH05221964A (ja) 1993-08-31
IL103692A0 (en) 1993-04-04

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