EA201391342A1 - Cd37-связывающие молекулы и их иммуноконъюгаты - Google Patents

Cd37-связывающие молекулы и их иммуноконъюгаты

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Publication number
EA201391342A1
EA201391342A1 EA201391342A EA201391342A EA201391342A1 EA 201391342 A1 EA201391342 A1 EA 201391342A1 EA 201391342 A EA201391342 A EA 201391342A EA 201391342 A EA201391342 A EA 201391342A EA 201391342 A1 EA201391342 A1 EA 201391342A1
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EA
Eurasian Patent Office
Prior art keywords
immunoconjugates
binding molecules
methods
oncogenic
antibodies
Prior art date
Application number
EA201391342A
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English (en)
Inventor
Джутта Декерт
Джулианто Сетиади
Питер У. Парк
Original Assignee
Иммьюноджен, Инк.
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Publication date
Application filed by Иммьюноджен, Инк. filed Critical Иммьюноджен, Инк.
Publication of EA201391342A1 publication Critical patent/EA201391342A1/ru

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    • A61K39/395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2896Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
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    • A61K39/39533Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39541Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against normal tissues, cells
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    • A61K39/3955Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
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Abstract

Предложены способы использования CD37-средств, включая, но не ограничиваясь перечисленным, антитела и иммуноконъюгаты, которые связываются с CD37 для снижения уровня B-клеток (например, неонкогенных B-клеток), а также способы лечения аутоиммунных и воспалительных заболеваний.
EA201391342A 2011-04-01 2012-03-30 Cd37-связывающие молекулы и их иммуноконъюгаты EA201391342A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161470863P 2011-04-01 2011-04-01
PCT/US2012/031648 WO2012135740A2 (en) 2011-04-01 2012-03-30 Cd37-binding molecules and immunoconjugates thereof

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EA201391342A1 true EA201391342A1 (ru) 2014-11-28

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US (3) US9447189B2 (ru)
EP (1) EP2694105A4 (ru)
JP (2) JP6018622B2 (ru)
KR (1) KR20140031883A (ru)
CN (2) CN103596590A (ru)
AU (2) AU2012236210B2 (ru)
BR (1) BR112013025208A2 (ru)
CA (1) CA2831111A1 (ru)
EA (1) EA201391342A1 (ru)
IL (1) IL228537A0 (ru)
MX (1) MX2013011385A (ru)
SG (1) SG193447A1 (ru)
WO (1) WO2012135740A2 (ru)
ZA (1) ZA201307302B (ru)

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