JP2016515524A5 - - Google Patents
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- Publication number
- JP2016515524A5 JP2016515524A5 JP2016503174A JP2016503174A JP2016515524A5 JP 2016515524 A5 JP2016515524 A5 JP 2016515524A5 JP 2016503174 A JP2016503174 A JP 2016503174A JP 2016503174 A JP2016503174 A JP 2016503174A JP 2016515524 A5 JP2016515524 A5 JP 2016515524A5
- Authority
- JP
- Japan
- Prior art keywords
- antibody
- seq
- chain variable
- variable region
- amino acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000006467 substitution reaction Methods 0.000 claims 15
- 125000003275 alpha amino acid group Chemical group 0.000 claims 9
- 239000012634 fragment Substances 0.000 claims 8
- 102220134332 rs142032681 Human genes 0.000 claims 6
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 4
- 102220623376 Non-histone chromosomal protein HMG-14_T54Y_mutation Human genes 0.000 claims 4
- 210000004027 cell Anatomy 0.000 claims 4
- 102200016465 rs104894275 Human genes 0.000 claims 4
- 239000008194 pharmaceutical composition Substances 0.000 claims 3
- 102220594689 Neurogenic differentiation factor 6_S29K_mutation Human genes 0.000 claims 2
- 208000000389 T-cell leukemia Diseases 0.000 claims 2
- 208000028530 T-cell lymphoblastic leukemia/lymphoma Diseases 0.000 claims 2
- 102220469723 Voltage-dependent L-type calcium channel subunit beta-2_S53K_mutation Human genes 0.000 claims 2
- 239000000611 antibody drug conjugate Substances 0.000 claims 2
- 229940049595 antibody-drug conjugate Drugs 0.000 claims 2
- 102000039446 nucleic acids Human genes 0.000 claims 2
- 150000007523 nucleic acids Chemical class 0.000 claims 2
- 108020004707 nucleic acids Proteins 0.000 claims 2
- 239000002773 nucleotide Substances 0.000 claims 2
- 125000003729 nucleotide group Chemical group 0.000 claims 2
- 102220320593 rs1554306309 Human genes 0.000 claims 2
- 102220092171 rs770694213 Human genes 0.000 claims 2
- 102220125344 rs886043940 Human genes 0.000 claims 2
- 101001057504 Homo sapiens Interferon-stimulated gene 20 kDa protein Proteins 0.000 claims 1
- 101001055144 Homo sapiens Interleukin-2 receptor subunit alpha Proteins 0.000 claims 1
- 206010061218 Inflammation Diseases 0.000 claims 1
- 102100026878 Interleukin-2 receptor subunit alpha Human genes 0.000 claims 1
- 206010052779 Transplant rejections Diseases 0.000 claims 1
- 206010046851 Uveitis Diseases 0.000 claims 1
- 241000700605 Viruses Species 0.000 claims 1
- 208000006673 asthma Diseases 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 230000004054 inflammatory process Effects 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 201000006417 multiple sclerosis Diseases 0.000 claims 1
- 210000000056 organ Anatomy 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361798235P | 2013-03-15 | 2013-03-15 | |
| US61/798,235 | 2013-03-15 | ||
| PCT/US2014/029634 WO2014145000A2 (en) | 2013-03-15 | 2014-03-14 | Anti-cd25 antibodies and their uses |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2016515524A JP2016515524A (ja) | 2016-05-30 |
| JP2016515524A5 true JP2016515524A5 (enExample) | 2017-04-13 |
Family
ID=50897881
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016503174A Pending JP2016515524A (ja) | 2013-03-15 | 2014-03-14 | 抗ｃｄ２５抗体およびそれらの使用 |
Country Status (11)
| Country | Link |
|---|---|
| US (3) | US20150010539A1 (enExample) |
| EP (2) | EP3216804A3 (enExample) |
| JP (1) | JP2016515524A (enExample) |
| CN (1) | CN105377892A (enExample) |
| AU (1) | AU2014233478A1 (enExample) |
| BR (1) | BR112015023084A2 (enExample) |
| CA (1) | CA2904532A1 (enExample) |
| HK (1) | HK1220470A1 (enExample) |
| MX (1) | MX2015012551A (enExample) |
| RU (1) | RU2015144026A (enExample) |
| WO (1) | WO2014145000A2 (enExample) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP4252629A3 (en) | 2016-12-07 | 2023-12-27 | Biora Therapeutics, Inc. | Gastrointestinal tract detection methods, devices and systems |
| US11879014B2 (en) | 2017-03-17 | 2024-01-23 | Tusk Therapeutics Ltd. | Method of treating cancer or depleting regulatory T cells in a subject by administering a human IGG1 anti-CD25 antibody |
| CN113603780B (zh) | 2017-03-28 | 2022-07-01 | 礼进生物医药科技（上海）有限公司 | 用于增强肿瘤微环境中免疫应答的治疗剂和方法 |
| US20210138213A1 (en) | 2017-03-30 | 2021-05-13 | Progenity, Inc. | Treatment of a disease of the gastrointestinal tract with an immune modulatory agent released using an ingestible device |
| US11697688B2 (en) | 2018-03-13 | 2023-07-11 | Tusk Therapeutics Ltd. | Anti-CD25 for tumour specific cell depletion |
| US20230041197A1 (en) | 2018-06-20 | 2023-02-09 | Progenity, Inc. | Treatment of a disease of the gastrointestinal tract with an immunomodulator |
| US12227565B2 (en) | 2018-06-20 | 2025-02-18 | Biora Therapeutics, Inc. | Method of formulating a pharmaceutical composition comprising administering an immune modulator to the small intestine |
| JP7482866B2 (ja) | 2018-11-19 | 2024-05-14 | ビオラ・セラピューティクス・インコーポレイテッド | 生物学的治療薬による疾患処置方法およびデバイス |
| CN121197633A (zh) | 2019-12-13 | 2025-12-26 | 比特比德科有限责任公司 | 用于将治疗剂递送至胃肠道的可摄取装置 |
| CN115397860B (zh) * | 2020-05-14 | 2025-06-13 | 江苏恒瑞医药股份有限公司 | 抗cd25抗体、其抗原结合片段及其医药用途 |
| JP7773172B2 (ja) * | 2021-06-11 | 2025-11-19 | 国立大学法人 新潟大学 | Ｔ細胞増殖促進ペプチド |
| EP4380604A1 (en) | 2021-08-05 | 2024-06-12 | Go Therapeutics, Inc. | Anti-glyco-muc4 antibodies and their uses |
| WO2023016455A1 (zh) * | 2021-08-09 | 2023-02-16 | 南京诺艾新生物技术有限公司 | 重组抗人cd25抗体及其应用 |
| EP4396232A1 (en) | 2021-09-03 | 2024-07-10 | Go Therapeutics, Inc. | Anti-glyco-lamp1 antibodies and their uses |
| JP2024536722A (ja) | 2021-09-03 | 2024-10-08 | ジーオー セラピューティクス，インコーポレイテッド | 抗グリコｃｍｅｔ抗体およびその使用 |
| CN115181182B (zh) * | 2022-06-13 | 2024-03-29 | 南京融捷康生物科技有限公司 | 一种人源化的抗cd25的单域抗体及其应用 |
| CN115181181B (zh) * | 2022-06-13 | 2024-03-29 | 南京融捷康生物科技有限公司 | 一种抗cd25的单域抗体及其应用 |
| EP4572772A1 (en) | 2022-08-17 | 2025-06-25 | Capstan Therapeutics, Inc. | Conditioning for in vivo immune cell engineering |
| CN120981564A (zh) | 2023-03-17 | 2025-11-18 | 圭尔医疗有限公司 | 调节性t细胞疗法 |
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| US4444887A (en) | 1979-12-10 | 1984-04-24 | Sloan-Kettering Institute | Process for making human antibody producing B-lymphocytes |
| US5179017A (en) | 1980-02-25 | 1993-01-12 | The Trustees Of Columbia University In The City Of New York | Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials |
| US4399216A (en) | 1980-02-25 | 1983-08-16 | The Trustees Of Columbia University | Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials |
| US4634665A (en) | 1980-02-25 | 1987-01-06 | The Trustees Of Columbia University In The City Of New York | Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials |
| US4716111A (en) | 1982-08-11 | 1987-12-29 | Trustees Of Boston University | Process for producing human antibodies |
| US4510245A (en) | 1982-11-18 | 1985-04-09 | Chiron Corporation | Adenovirus promoter system |
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-
2014
- 2014-03-14 CN CN201480021398.5A patent/CN105377892A/zh active Pending
- 2014-03-14 AU AU2014233478A patent/AU2014233478A1/en not_active Abandoned
- 2014-03-14 HK HK16108469.7A patent/HK1220470A1/zh unknown
- 2014-03-14 US US14/214,089 patent/US20150010539A1/en not_active Abandoned
- 2014-03-14 MX MX2015012551A patent/MX2015012551A/es unknown
- 2014-03-14 EP EP17157958.4A patent/EP3216804A3/en not_active Withdrawn
- 2014-03-14 RU RU2015144026A patent/RU2015144026A/ru not_active Application Discontinuation
- 2014-03-14 CA CA2904532A patent/CA2904532A1/en not_active Abandoned
- 2014-03-14 EP EP14729110.8A patent/EP2970488A2/en not_active Withdrawn
- 2014-03-14 BR BR112015023084A patent/BR112015023084A2/pt active Search and Examination
- 2014-03-14 JP JP2016503174A patent/JP2016515524A/ja active Pending
- 2014-03-14 WO PCT/US2014/029634 patent/WO2014145000A2/en not_active Ceased
-
2017
- 2017-05-03 US US15/585,404 patent/US20170233481A1/en not_active Abandoned
-
2020
- 2020-06-11 US US16/899,399 patent/US20200308290A1/en not_active Abandoned
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