JP2019187424A5 - - Google Patents
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- Publication number
- JP2019187424A5 JP2019187424A5 JP2019104273A JP2019104273A JP2019187424A5 JP 2019187424 A5 JP2019187424 A5 JP 2019187424A5 JP 2019104273 A JP2019104273 A JP 2019104273A JP 2019104273 A JP2019104273 A JP 2019104273A JP 2019187424 A5 JP2019187424 A5 JP 2019187424A5
- Authority
- JP
- Japan
- Prior art keywords
- polymerase
- seq
- amino acid
- dna polymerase
- acid substitution
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 102000016928 DNA-directed DNA polymerase Human genes 0.000 claims 4
- 108010014303 DNA-directed DNA polymerase Proteins 0.000 claims 4
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 3
- 125000003275 alpha amino acid group Chemical group 0.000 claims 3
- 238000006467 substitution reaction Methods 0.000 claims 3
- 230000035772 mutation Effects 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2021086806A JP2021121221A (ja) | 2015-05-14 | 2021-05-24 | ポリメラーゼバリアントおよびその使用 |
Applications Claiming Priority (8)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562161571P | 2015-05-14 | 2015-05-14 | |
| US62/161,571 | 2015-05-14 | ||
| US201562202895P | 2015-08-09 | 2015-08-09 | |
| US62/202,895 | 2015-08-09 | ||
| US15/012,317 US10308918B2 (en) | 2015-02-02 | 2016-02-01 | Polymerase variants |
| US15/012,317 | 2016-02-01 | ||
| US15/151,364 US10526588B2 (en) | 2015-05-14 | 2016-05-10 | Polymerase variants and uses thereof |
| US15/151,364 | 2016-05-10 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017559318A Division JP2018515103A (ja) | 2015-05-14 | 2016-05-13 | ポリメラーゼバリアントおよびその使用 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021086806A Division JP2021121221A (ja) | 2015-05-14 | 2021-05-24 | ポリメラーゼバリアントおよびその使用 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2019187424A JP2019187424A (ja) | 2019-10-31 |
| JP2019187424A5 true JP2019187424A5 (enExample) | 2020-04-09 |
Family
ID=57248698
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017559318A Pending JP2018515103A (ja) | 2015-05-14 | 2016-05-13 | ポリメラーゼバリアントおよびその使用 |
| JP2019104273A Pending JP2019187424A (ja) | 2015-05-14 | 2019-06-04 | ポリメラーゼバリアントおよびその使用 |
| JP2021086806A Pending JP2021121221A (ja) | 2015-05-14 | 2021-05-24 | ポリメラーゼバリアントおよびその使用 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017559318A Pending JP2018515103A (ja) | 2015-05-14 | 2016-05-13 | ポリメラーゼバリアントおよびその使用 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021086806A Pending JP2021121221A (ja) | 2015-05-14 | 2021-05-24 | ポリメラーゼバリアントおよびその使用 |
Country Status (6)
| Country | Link |
|---|---|
| US (3) | US10526588B2 (enExample) |
| EP (1) | EP3294749A4 (enExample) |
| JP (3) | JP2018515103A (enExample) |
| CN (1) | CN107636004A (enExample) |
| CA (2) | CA3028797C (enExample) |
| WO (1) | WO2016183403A2 (enExample) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107257854B (zh) * | 2015-02-02 | 2022-02-15 | 豪夫迈·罗氏有限公司 | 聚合酶变体 |
| US10526588B2 (en) * | 2015-05-14 | 2020-01-07 | Roche Sequencing Solutions, Inc. | Polymerase variants and uses thereof |
| ES2846949T3 (es) | 2015-11-16 | 2021-07-30 | Stratos Genomics Inc | Variantes de la polimerasa DPO4 |
| US20170268052A1 (en) * | 2016-02-29 | 2017-09-21 | Genia Technologies, Inc. | Polymerase-template complexes |
| US10590480B2 (en) | 2016-02-29 | 2020-03-17 | Roche Sequencing Solutions, Inc. | Polymerase variants |
| JP6959931B2 (ja) | 2016-02-29 | 2021-11-05 | ジェニア・テクノロジーズ・インコーポレイテッド | エキソヌクレアーゼ欠損ポリメラーゼ |
| US10655174B2 (en) | 2016-05-27 | 2020-05-19 | Roche Sequencing Solutions, Inc. | Tagged multi-nucleotides useful for nucleic acid sequencing |
| US10669580B2 (en) | 2016-08-26 | 2020-06-02 | Roche Sequencing Solutions, Inc. | Tagged nucleotides useful for nanopore detection |
| CN110114458A (zh) | 2016-09-22 | 2019-08-09 | 豪夫迈·罗氏有限公司 | Pol6聚合酶变体 |
| WO2018204707A1 (en) | 2017-05-04 | 2018-11-08 | Stratos Genomics Inc. | Dp04 polymerase variants |
| AU2018383610B2 (en) * | 2017-12-11 | 2024-09-12 | F. Hoffmann-La Roche Ag | DPO4 polymerase variants with improved accuracy |
| EP3759116A1 (en) | 2018-02-28 | 2021-01-06 | F. Hoffmann-La Roche AG | Tagged nucleoside compounds useful for nanopore detection |
| WO2019166458A1 (en) | 2018-02-28 | 2019-09-06 | F. Hoffmann-La Roche Ag | Alpha-hemolysin variants and uses thereof |
| EP4100415A1 (en) | 2020-02-06 | 2022-12-14 | F. Hoffmann-La Roche AG | Compositions that reduce template threading into a nanopore |
| US20240150824A1 (en) | 2020-08-11 | 2024-05-09 | Roche Sequencing Solutions, Inc. | Nucleoside-5'-oligophosphates tagged with postiviely-charged polymers, nanopores incorporating negative charges, and methods and systems using the same |
| WO2022263489A1 (en) | 2021-06-17 | 2022-12-22 | F. Hoffmann-La Roche Ag | Nucleoside-5 -oligophosphates having a cationically-modified nucleobase |
| WO2022263496A1 (en) | 2021-06-17 | 2022-12-22 | F. Hoffmann-La Roche Ag | Engineered nanopore with a negatively charged polymer threaded through the channel |
| US20250084471A1 (en) | 2021-07-21 | 2025-03-13 | Roche Sequencing Solutions, Inc. | Alpha-hemolysin variants forming narrow channel pores and uses thereof |
| WO2023089175A1 (en) | 2021-11-22 | 2023-05-25 | F. Hoffmann-La Roche Ag | Thermostable polymerase variants |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4683202A (en) | 1985-03-28 | 1987-07-28 | Cetus Corporation | Process for amplifying nucleic acid sequences |
| US6346379B1 (en) | 1997-09-11 | 2002-02-12 | F. Hoffman-La Roche Ag | Thermostable DNA polymerases incorporating nucleoside triphosphates labeled with fluorescein family dyes |
| WO2006028508A2 (en) | 2004-03-23 | 2006-03-16 | President And Fellows Of Harvard College | Methods and apparatus for characterizing polynucleotides |
| WO2006120433A1 (en) | 2005-05-10 | 2006-11-16 | Solexa Limited | Improved polymerases |
| GB0509508D0 (en) | 2005-05-10 | 2005-06-15 | Solexa Ltd | Improved polymerases |
| CA2720483A1 (en) | 2008-04-04 | 2009-10-08 | It-Is International Ltd. | Thermal control system and method for chemical and biochemical reactions |
| EP3101124B1 (en) * | 2008-11-03 | 2019-06-19 | Kapa Biosystems, Inc. | Modified type a dna polymerases |
| EP2843405B8 (en) | 2010-02-08 | 2023-10-04 | Roche Sequencing Solutions, Inc. | Systems and methods for manipulating a molecule in a nanopore |
| GB201002362D0 (en) | 2010-02-11 | 2010-03-31 | Isis Innovation | Peptide tag systems that spontaneously form an irreversible link to protein partners via isopeptide bonds |
| US8936911B2 (en) | 2010-09-22 | 2015-01-20 | Pacific Biosciences Of California, Inc. | Purified extended polymerase/template complex for sequencing |
| US10443096B2 (en) | 2010-12-17 | 2019-10-15 | The Trustees Of Columbia University In The City Of New York | DNA sequencing by synthesis using modified nucleotides and nanopore detection |
| EP2689028B1 (en) | 2011-03-23 | 2017-08-30 | Pacific Biosciences Of California, Inc. | Isolation of polymerase-nucleic acid complexes and loading onto substrates |
| WO2012173905A1 (en) | 2011-06-16 | 2012-12-20 | The Regents Of The Unversity Of California | Salt-tolerant dna polymerases |
| LT2742151T (lt) | 2011-08-10 | 2018-02-12 | Life Technologies Corporation | Polimerazės kompozicija |
| GB2510719A (en) | 2012-06-15 | 2014-08-13 | Genia Technologies Inc | Chip set-up and high-accuracy nucleic acid sequencing |
| US9605309B2 (en) | 2012-11-09 | 2017-03-28 | Genia Technologies, Inc. | Nucleic acid sequencing using tags |
| US9322062B2 (en) | 2013-10-23 | 2016-04-26 | Genia Technologies, Inc. | Process for biosensor well formation |
| CN107257854B (zh) | 2015-02-02 | 2022-02-15 | 豪夫迈·罗氏有限公司 | 聚合酶变体 |
| JP2016171215A (ja) | 2015-03-12 | 2016-09-23 | 株式会社東芝 | 半導体記憶装置 |
| US10526588B2 (en) | 2015-05-14 | 2020-01-07 | Roche Sequencing Solutions, Inc. | Polymerase variants and uses thereof |
| ES2880331T3 (es) | 2016-02-29 | 2021-11-24 | Genia Tech Inc | Variantes de polimerasa |
| JP6959931B2 (ja) | 2016-02-29 | 2021-11-05 | ジェニア・テクノロジーズ・インコーポレイテッド | エキソヌクレアーゼ欠損ポリメラーゼ |
-
2016
- 2016-05-10 US US15/151,364 patent/US10526588B2/en active Active
- 2016-05-13 WO PCT/US2016/032258 patent/WO2016183403A2/en not_active Ceased
- 2016-05-13 CN CN201680027667.8A patent/CN107636004A/zh active Pending
- 2016-05-13 JP JP2017559318A patent/JP2018515103A/ja active Pending
- 2016-05-13 CA CA3028797A patent/CA3028797C/en active Active
- 2016-05-13 EP EP16793584.0A patent/EP3294749A4/en not_active Withdrawn
- 2016-05-13 CA CA2978194A patent/CA2978194C/en active Active
-
2019
- 2019-06-04 JP JP2019104273A patent/JP2019187424A/ja active Pending
- 2019-11-25 US US16/694,985 patent/US10968438B2/en active Active
-
2021
- 2021-03-05 US US17/249,605 patent/US11788073B2/en active Active
- 2021-05-24 JP JP2021086806A patent/JP2021121221A/ja active Pending
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