JP2019194236A5 - - Google Patents
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- JP2019194236A5 JP2019194236A5 JP2019127476A JP2019127476A JP2019194236A5 JP 2019194236 A5 JP2019194236 A5 JP 2019194236A5 JP 2019127476 A JP2019127476 A JP 2019127476A JP 2019127476 A JP2019127476 A JP 2019127476A JP 2019194236 A5 JP2019194236 A5 JP 2019194236A5
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- Prior art keywords
- compound
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- 150000001875 compounds Chemical class 0.000 claims 43
- 150000003839 salts Chemical class 0.000 claims 23
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2022041396A JP7375072B2 (ja) | 2014-09-17 | 2022-03-16 | Ｍｋ２阻害剤およびその使用 |
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462051788P | 2014-09-17 | 2014-09-17 | |
| US62/051,788 | 2014-09-17 | ||
| US201562199927P | 2015-07-31 | 2015-07-31 | |
| US62/199,927 | 2015-07-31 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017515845A Division JP6556225B2 (ja) | 2014-09-17 | 2015-09-16 | Ｍｋ２阻害剤およびその使用 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022041396A Division JP7375072B2 (ja) | 2014-09-17 | 2022-03-16 | Ｍｋ２阻害剤およびその使用 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2019194236A JP2019194236A (ja) | 2019-11-07 |
| JP2019194236A5 true JP2019194236A5 (enExample) | 2019-12-19 |
Family
ID=55454109
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017515845A Active JP6556225B2 (ja) | 2014-09-17 | 2015-09-16 | Ｍｋ２阻害剤およびその使用 |
| JP2019127476A Pending JP2019194236A (ja) | 2014-09-17 | 2019-07-09 | Ｍｋ２阻害剤およびその使用 |
| JP2022041396A Active JP7375072B2 (ja) | 2014-09-17 | 2022-03-16 | Ｍｋ２阻害剤およびその使用 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017515845A Active JP6556225B2 (ja) | 2014-09-17 | 2015-09-16 | Ｍｋ２阻害剤およびその使用 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022041396A Active JP7375072B2 (ja) | 2014-09-17 | 2022-03-16 | Ｍｋ２阻害剤およびその使用 |
Country Status (30)
| Country | Link |
|---|---|
| US (5) | US9458175B2 (enExample) |
| EP (2) | EP3193611B1 (enExample) |
| JP (3) | JP6556225B2 (enExample) |
| KR (1) | KR102457848B1 (enExample) |
| CN (1) | CN106998692B (enExample) |
| AU (1) | AU2015317741B2 (enExample) |
| BR (1) | BR112017005266B1 (enExample) |
| CA (1) | CA2961607C (enExample) |
| CL (1) | CL2017000576A1 (enExample) |
| CO (1) | CO2017003279A2 (enExample) |
| CY (1) | CY1124215T1 (enExample) |
| DK (1) | DK3193611T3 (enExample) |
| EA (1) | EA037299B1 (enExample) |
| EC (1) | ECSP17023281A (enExample) |
| ES (1) | ES2874561T3 (enExample) |
| HR (1) | HRP20210529T1 (enExample) |
| HU (1) | HUE054347T2 (enExample) |
| IL (1) | IL251051B (enExample) |
| LT (1) | LT3193611T (enExample) |
| MA (1) | MA40534B1 (enExample) |
| MX (2) | MX373341B (enExample) |
| PL (1) | PL3193611T3 (enExample) |
| PT (1) | PT3193611T (enExample) |
| RS (1) | RS62017B1 (enExample) |
| SA (1) | SA517381115B1 (enExample) |
| SG (2) | SG11201701861RA (enExample) |
| SI (1) | SI3193611T1 (enExample) |
| SM (1) | SMT202100311T1 (enExample) |
| TW (1) | TWI744217B (enExample) |
| WO (1) | WO2016044463A2 (enExample) |
Families Citing this family (25)
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| KR20210091832A (ko) | 2013-03-15 | 2021-07-22 | 셀젠 카르 엘엘씨 | Mk2 억제제 및 이의 용도 |
| AU2015317741B2 (en) | 2014-09-17 | 2020-01-16 | Bristol-Myers Squibb Company | MK2 inhibitors and uses thereof |
| CN106632077B (zh) * | 2016-10-10 | 2019-01-22 | 上海再启生物技术有限公司 | 一种2-氨基-4-溴嘧啶的制备方法 |
| JP7282039B2 (ja) * | 2017-03-16 | 2023-05-26 | セルジーン シーエーアール エルエルシー | Ｍｋ２阻害剤、その合成、およびそれに至るまでの中間体 |
| US10882867B2 (en) * | 2017-03-16 | 2021-01-05 | Celgene Car Llc | Forms and compositions of a MK2 inhibitor |
| EP3596084A4 (en) * | 2017-03-16 | 2020-12-23 | Celgene CAR LLC | 9,10,11,12-TETRAHYDRO-8H- [1,4] DIAZEPINO [5 ', 6': 4,5] THIÉNO [3,2-F] QUINOLIN-8-ONE COMPOUNDS AND THEIR USES |
| JP7200120B2 (ja) * | 2017-03-16 | 2023-01-06 | セルジーン シーエーアール エルエルシー | Ｍｋ２阻害剤として有用なヘテロアリール化合物 |
| WO2018170201A1 (en) | 2017-03-16 | 2018-09-20 | Celgene Car Llc | Deuterated analogs of mk2 inhibitors and uses thereof |
| CN107058259A (zh) * | 2017-05-18 | 2017-08-18 | 南京中医药大学 | 分子标志物mk2基因及其应用 |
| CA3114883A1 (en) * | 2018-10-02 | 2020-04-09 | Disc Medicine, Inc. | Matriptase 2 inhibitors and uses thereof |
| US20220251105A1 (en) * | 2019-05-17 | 2022-08-11 | Celgene Car Llc | Methods of treating a mk2-mediated disorder |
| CN115515588A (zh) | 2020-02-14 | 2022-12-23 | 萨克生物研究学院 | 大环ulk1/2抑制剂 |
| AU2021218740A1 (en) * | 2020-02-14 | 2022-09-22 | Salk Institute For Biological Studies | Mono and combination therapies with ULK1/2 inhibitors |
| EP4114411A4 (en) * | 2020-03-02 | 2024-04-24 | Washington University | Compositions and methods for the treatment of pancreatic cancer |
| EP4185382A4 (en) * | 2020-07-24 | 2024-09-04 | Bristol-Myers Squibb Company | Methods of treating acute respiratory disorders |
| CA3201774A1 (en) * | 2020-11-12 | 2022-05-19 | Akttyva Therapeutics, Inc. | Mk2 activating compounds for use in treating vascular leak and endothelial barrier disorders |
| TW202246282A (zh) | 2021-02-01 | 2022-12-01 | 美商西建公司 | Ｍｋ２抑制劑、其合成及其中間體 |
| EP4079855A1 (en) * | 2021-04-20 | 2022-10-26 | Eberhard Karls Universität Tübingen Medizinische Fakultät | Compound and method for the prophylaxis and treatment of leukemia |
| TW202328141A (zh) * | 2021-08-27 | 2023-07-16 | 大陸商瑞石生物醫藥有限公司 | 喹啉并呋喃衍生物及其用途 |
| WO2023134764A1 (zh) | 2022-01-14 | 2023-07-20 | 上海翰森生物医药科技有限公司 | 含吡啶多环类衍生物、其制备方法和应用 |
| WO2024044731A1 (en) * | 2022-08-26 | 2024-02-29 | Matchpoint Therapeutics Inc. | Diazepino-thieno-quinoxaline compounds and their use in therapy |
| CN120390642A (zh) * | 2022-10-27 | 2025-07-29 | 百时美施贵宝公司 | Mk2抑制剂及其用途 |
| KR20250139398A (ko) * | 2023-02-07 | 2025-09-23 | 셀진 코포레이션 | Mk2 키나제의 분해제로서 유용한 화합물 및 조성물 |
| WO2024229401A2 (en) * | 2023-05-04 | 2024-11-07 | Matchpoint Therapeutics Inc. | Diazepino-thieno-quinoxaline compounds and their use in therapy |
| CN121368484A (zh) * | 2023-06-26 | 2026-01-20 | 深圳信立泰药业股份有限公司 | 一种mk2抑制剂在制备预防和/或治疗疾病药物中的应用 |
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| JP2011500727A (ja) | 2007-10-22 | 2011-01-06 | シェーリング コーポレイション | Ｇｐｒ１１９の活性のモジュレーターとしての二環式ヘテロ環誘導体およびその使用 |
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| US10512651B2 (en) | 2014-08-25 | 2019-12-24 | Stc.Unm | Inhibition of MK2 in the treatment of cancer |
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| JP7282039B2 (ja) | 2017-03-16 | 2023-05-26 | セルジーン シーエーアール エルエルシー | Ｍｋ２阻害剤、その合成、およびそれに至るまでの中間体 |
| JP7200120B2 (ja) | 2017-03-16 | 2023-01-06 | セルジーン シーエーアール エルエルシー | Ｍｋ２阻害剤として有用なヘテロアリール化合物 |
| EP3596084A4 (en) | 2017-03-16 | 2020-12-23 | Celgene CAR LLC | 9,10,11,12-TETRAHYDRO-8H- [1,4] DIAZEPINO [5 ', 6': 4,5] THIÉNO [3,2-F] QUINOLIN-8-ONE COMPOUNDS AND THEIR USES |
| US10882867B2 (en) | 2017-03-16 | 2021-01-05 | Celgene Car Llc | Forms and compositions of a MK2 inhibitor |
| WO2018170201A1 (en) | 2017-03-16 | 2018-09-20 | Celgene Car Llc | Deuterated analogs of mk2 inhibitors and uses thereof |
| US20220251105A1 (en) | 2019-05-17 | 2022-08-11 | Celgene Car Llc | Methods of treating a mk2-mediated disorder |
| EP4185382A4 (en) | 2020-07-24 | 2024-09-04 | Bristol-Myers Squibb Company | Methods of treating acute respiratory disorders |
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2015
- 2015-09-16 AU AU2015317741A patent/AU2015317741B2/en active Active
- 2015-09-16 ES ES15842903T patent/ES2874561T3/es active Active
- 2015-09-16 CA CA2961607A patent/CA2961607C/en active Active
- 2015-09-16 JP JP2017515845A patent/JP6556225B2/ja active Active
- 2015-09-16 KR KR1020177010439A patent/KR102457848B1/ko active Active
- 2015-09-16 CN CN201580058026.4A patent/CN106998692B/zh active Active
- 2015-09-16 LT LTEP15842903.5T patent/LT3193611T/lt unknown
- 2015-09-16 MX MX2017003359A patent/MX373341B/es active IP Right Grant
- 2015-09-16 TW TW104130645A patent/TWI744217B/zh active
- 2015-09-16 HU HUE15842903A patent/HUE054347T2/hu unknown
- 2015-09-16 HR HRP20210529TT patent/HRP20210529T1/hr unknown
- 2015-09-16 DK DK15842903.5T patent/DK3193611T3/da active
- 2015-09-16 EP EP15842903.5A patent/EP3193611B1/en active Active
- 2015-09-16 SG SG11201701861RA patent/SG11201701861RA/en unknown
- 2015-09-16 BR BR112017005266-0A patent/BR112017005266B1/pt active IP Right Grant
- 2015-09-16 SG SG10201902326XA patent/SG10201902326XA/en unknown
- 2015-09-16 PT PT158429035T patent/PT3193611T/pt unknown
- 2015-09-16 MA MA40534A patent/MA40534B1/fr unknown
- 2015-09-16 US US14/856,311 patent/US9458175B2/en active Active
- 2015-09-16 RS RS20210725A patent/RS62017B1/sr unknown
- 2015-09-16 EP EP21164056.0A patent/EP3912981A1/en active Pending
- 2015-09-16 EA EA201790380A patent/EA037299B1/ru not_active IP Right Cessation
- 2015-09-16 SM SM20210311T patent/SMT202100311T1/it unknown
- 2015-09-16 PL PL15842903T patent/PL3193611T3/pl unknown
- 2015-09-16 SI SI201531617T patent/SI3193611T1/sl unknown
- 2015-09-16 WO PCT/US2015/050495 patent/WO2016044463A2/en not_active Ceased
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2016
- 2016-09-29 US US15/280,157 patent/US9790235B2/en active Active
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2017
- 2017-03-09 IL IL25105117A patent/IL251051B/en active IP Right Grant
- 2017-03-09 CL CL2017000576A patent/CL2017000576A1/es unknown
- 2017-03-14 MX MX2020005213A patent/MX2020005213A/es unknown
- 2017-03-16 SA SA517381115A patent/SA517381115B1/ar unknown
- 2017-04-04 CO CONC2017/0003279A patent/CO2017003279A2/es unknown
- 2017-04-13 EC ECIEPI201723281A patent/ECSP17023281A/es unknown
- 2017-10-13 US US15/782,995 patent/US10253040B1/en active Active
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2019
- 2019-04-04 US US16/375,317 patent/US10577380B2/en active Active
- 2019-07-09 JP JP2019127476A patent/JP2019194236A/ja active Pending
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2020
- 2020-02-27 US US16/802,654 patent/US11584757B2/en active Active
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2021
- 2021-06-09 CY CY20211100504T patent/CY1124215T1/el unknown
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2022
- 2022-03-16 JP JP2022041396A patent/JP7375072B2/ja active Active