JP2019194236A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2019194236A5 JP2019194236A5 JP2019127476A JP2019127476A JP2019194236A5 JP 2019194236 A5 JP2019194236 A5 JP 2019194236A5 JP 2019127476 A JP2019127476 A JP 2019127476A JP 2019127476 A JP2019127476 A JP 2019127476A JP 2019194236 A5 JP2019194236 A5 JP 2019194236A5
- Authority
- JP
- Japan
- Prior art keywords
- compound
- salt
- compound according
- group
- compound selected
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 150000001875 compounds Chemical class 0.000 claims 43
- 150000003839 salts Chemical class 0.000 claims 23
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2022041396A JP7375072B2 (ja) | 2014-09-17 | 2022-03-16 | Ｍｋ２阻害剤およびその使用 |
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462051788P | 2014-09-17 | 2014-09-17 | |
| US62/051,788 | 2014-09-17 | ||
| US201562199927P | 2015-07-31 | 2015-07-31 | |
| US62/199,927 | 2015-07-31 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017515845A Division JP6556225B2 (ja) | 2014-09-17 | 2015-09-16 | Ｍｋ２阻害剤およびその使用 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022041396A Division JP7375072B2 (ja) | 2014-09-17 | 2022-03-16 | Ｍｋ２阻害剤およびその使用 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2019194236A JP2019194236A (ja) | 2019-11-07 |
| JP2019194236A5 true JP2019194236A5 (enExample) | 2019-12-19 |
Family
ID=55454109
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017515845A Active JP6556225B2 (ja) | 2014-09-17 | 2015-09-16 | Ｍｋ２阻害剤およびその使用 |
| JP2019127476A Pending JP2019194236A (ja) | 2014-09-17 | 2019-07-09 | Ｍｋ２阻害剤およびその使用 |
| JP2022041396A Active JP7375072B2 (ja) | 2014-09-17 | 2022-03-16 | Ｍｋ２阻害剤およびその使用 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017515845A Active JP6556225B2 (ja) | 2014-09-17 | 2015-09-16 | Ｍｋ２阻害剤およびその使用 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022041396A Active JP7375072B2 (ja) | 2014-09-17 | 2022-03-16 | Ｍｋ２阻害剤およびその使用 |
Country Status (30)
| Country | Link |
|---|---|
| US (5) | US9458175B2 (enExample) |
| EP (2) | EP3912981A1 (enExample) |
| JP (3) | JP6556225B2 (enExample) |
| KR (1) | KR102457848B1 (enExample) |
| CN (1) | CN106998692B (enExample) |
| AU (1) | AU2015317741B2 (enExample) |
| BR (1) | BR112017005266B1 (enExample) |
| CA (1) | CA2961607C (enExample) |
| CL (1) | CL2017000576A1 (enExample) |
| CO (1) | CO2017003279A2 (enExample) |
| CY (1) | CY1124215T1 (enExample) |
| DK (1) | DK3193611T3 (enExample) |
| EA (1) | EA037299B1 (enExample) |
| EC (1) | ECSP17023281A (enExample) |
| ES (1) | ES2874561T3 (enExample) |
| HR (1) | HRP20210529T1 (enExample) |
| HU (1) | HUE054347T2 (enExample) |
| IL (1) | IL251051B (enExample) |
| LT (1) | LT3193611T (enExample) |
| MA (1) | MA40534B1 (enExample) |
| MX (2) | MX373341B (enExample) |
| PL (1) | PL3193611T3 (enExample) |
| PT (1) | PT3193611T (enExample) |
| RS (1) | RS62017B1 (enExample) |
| SA (1) | SA517381115B1 (enExample) |
| SG (2) | SG10201902326XA (enExample) |
| SI (1) | SI3193611T1 (enExample) |
| SM (1) | SMT202100311T1 (enExample) |
| TW (1) | TWI744217B (enExample) |
| WO (1) | WO2016044463A2 (enExample) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2908098A1 (en) | 2013-03-15 | 2014-09-25 | Celgene Avilomics Research, Inc. | Mk2 inhibitors and uses thereof |
| BR112017005266B1 (pt) | 2014-09-17 | 2022-11-01 | Celgene Car Llc | Compostos inibidores de mk2 e composição farmaceuticamente aceitável que os compreende |
| CN106632077B (zh) * | 2016-10-10 | 2019-01-22 | 上海再启生物技术有限公司 | 一种2-氨基-4-溴嘧啶的制备方法 |
| MX387359B (es) * | 2017-03-16 | 2025-03-18 | Bristol Myers Squibb Co | Inhibidores de cinasa activada por mitógeno 2 (mk2), síntesis de los mismos, e intermediarios de los mismos. |
| WO2018170200A1 (en) | 2017-03-16 | 2018-09-20 | Celgene Car Llc | Heteroaryl compounds useful as mk2 inhibitors |
| WO2018170201A1 (en) | 2017-03-16 | 2018-09-20 | Celgene Car Llc | Deuterated analogs of mk2 inhibitors and uses thereof |
| US11098057B2 (en) * | 2017-03-16 | 2021-08-24 | Celgene Car Llc | 9,10,11,12-tetrahydro-8H-[1,4]diazepino[5′,6′:4,5]thieno[3,2-F]quinolin-8-one compounds and uses thereof |
| WO2018170199A1 (en) | 2017-03-16 | 2018-09-20 | Celgene Car Llc | Forms and compositions of a mk2 inhibitor |
| CN107058259A (zh) * | 2017-05-18 | 2017-08-18 | 南京中医药大学 | 分子标志物mk2基因及其应用 |
| CA3114883A1 (en) * | 2018-10-02 | 2020-04-09 | Disc Medicine, Inc. | Matriptase 2 inhibitors and uses thereof |
| WO2020236636A1 (en) * | 2019-05-17 | 2020-11-26 | Celgene Car Llc | Methods of treating a mk2-mediated disorder |
| EP4103186A4 (en) * | 2020-02-14 | 2024-03-06 | Salk Institute for Biological Studies | MONOTHERAPIES AND COMBINATION THERAPIES WITH ULK1/2 INHIBITORS |
| US20230087078A1 (en) * | 2020-03-02 | 2023-03-23 | Washington University | Compositions and methods for the treatment of pancreatic cancer |
| WO2022020562A1 (en) * | 2020-07-24 | 2022-01-27 | Bristol-Myers Squibb Company | Methods of treating acute respiratory disorders |
| WO2022104097A2 (en) * | 2020-11-12 | 2022-05-19 | Akttyva Therapeutics, Inc. | Mk2 activating compounds for use in treating vascular leak and endothelial barrier disorders |
| CN116670142A (zh) * | 2021-02-01 | 2023-08-29 | 细胞基因公司 | Mk2抑制剂、其合成和其中间体 |
| EP4079855A1 (en) * | 2021-04-20 | 2022-10-26 | Eberhard Karls Universität Tübingen Medizinische Fakultät | Compound and method for the prophylaxis and treatment of leukemia |
| WO2023025298A1 (zh) * | 2021-08-27 | 2023-03-02 | 瑞石生物医药有限公司 | 喹啉并呋喃衍生物及其用途 |
| KR20240134978A (ko) | 2022-01-14 | 2024-09-10 | 상하이 한서 바이오메디컬 컴퍼니 리미티드 | 피리딘 함유 폴리시클릭 유도체, 이의 제조 방법 및 용도 |
| WO2024044731A1 (en) * | 2022-08-26 | 2024-02-29 | Matchpoint Therapeutics Inc. | Diazepino-thieno-quinoxaline compounds and their use in therapy |
| EP4608401A2 (en) * | 2022-10-27 | 2025-09-03 | Bristol-Myers Squibb Company | Mk2 inhibitors and uses thereof |
| WO2024167950A1 (en) * | 2023-02-07 | 2024-08-15 | Celgene Corporation | Compounds and compositions useful as degraders of mk2 kinase |
| WO2024229401A2 (en) * | 2023-05-04 | 2024-11-07 | Matchpoint Therapeutics Inc. | Diazepino-thieno-quinoxaline compounds and their use in therapy |
| WO2025002076A1 (zh) * | 2023-06-26 | 2025-01-02 | 深圳信立泰药业股份有限公司 | 一种mk2抑制剂在制备预防和/或治疗疾病药物中的应用 |
Family Cites Families (40)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5015778A (en) | 1989-12-18 | 1991-05-14 | The Dow Chemical Company | Catalytic method to produce hydroxy substituted arylophenones |
| AU707748B2 (en) | 1994-03-25 | 1999-07-22 | Isotechnika Inc. | Enhancement of the efficacy of drugs by deuteration |
| US5441946A (en) | 1994-04-14 | 1995-08-15 | Rhone-Poulenc-Rorer Pharmaceuticals, Inc. | Phosphonate derivatives of lipophilic amines |
| GB9828511D0 (en) * | 1998-12-24 | 1999-02-17 | Zeneca Ltd | Chemical compounds |
| US6861440B2 (en) * | 2001-10-26 | 2005-03-01 | Hoffmann-La Roche Inc. | DPP IV inhibitors |
| TW200413273A (en) | 2002-11-15 | 2004-08-01 | Wako Pure Chem Ind Ltd | Heavy hydrogenation method of heterocyclic rings |
| CN1747949A (zh) | 2002-12-20 | 2006-03-15 | 法马西亚公司 | 无环吡唑化合物 |
| EP1663204B1 (en) | 2003-08-29 | 2014-05-07 | Exelixis, Inc. | C-kit modulators and methods of use |
| US20060106020A1 (en) | 2004-04-28 | 2006-05-18 | Rodgers James D | Tetracyclic inhibitors of Janus kinases |
| SG159528A1 (en) | 2005-02-04 | 2010-03-30 | Senomyx Inc | Compounds comprising linked hetero aryl moieties and their use as novel umami flavor modifiers, tastants and taste enhancers for comestible compositions |
| EP1849781A1 (en) | 2006-04-28 | 2007-10-31 | Laboratorios del Dr. Esteve S.A. | Substituted 3-Amino-4-hydroxy pyrrolidines compounds, their preparation and use as medicaments |
| JP2010505961A (ja) | 2006-10-09 | 2010-02-25 | タケダ サン ディエゴ インコーポレイテッド | キナーゼ阻害剤 |
| CA2693904A1 (en) | 2007-07-16 | 2009-01-22 | Novartis Ag | Heterocyclic compounds useful as mk2 inhibitors |
| JP2011500727A (ja) | 2007-10-22 | 2011-01-06 | シェーリング コーポレイション | Ｇｐｒ１１９の活性のモジュレーターとしての二環式ヘテロ環誘導体およびその使用 |
| NZ624345A (en) | 2008-06-27 | 2016-07-29 | Celgene Avilomics Res Inc | 2,4-disubstituted pyrimidines useful as kinase inhibitors |
| US8338439B2 (en) | 2008-06-27 | 2012-12-25 | Celgene Avilomics Research, Inc. | 2,4-disubstituted pyrimidines useful as kinase inhibitors |
| WO2010048149A2 (en) | 2008-10-20 | 2010-04-29 | Kalypsys, Inc. | Heterocyclic modulators of gpr119 for treatment of disease |
| US20110269744A1 (en) * | 2010-03-12 | 2011-11-03 | Astellas Pharma Inc. | Benzazepine Compound |
| WO2011153553A2 (en) * | 2010-06-04 | 2011-12-08 | The Regents Of The University Of California | Methods and compositions for kinase inhibition |
| EP2508511A1 (en) * | 2011-04-07 | 2012-10-10 | Laboratoire Biodim | Inhibitors of viral replication, their process of preparation and their therapeutical uses |
| ES2742261T3 (es) * | 2011-04-15 | 2020-02-13 | Hivih | Inhibidores de la replicación viral, su proceso de preparación y sus usos terapéuticos |
| US10934487B2 (en) | 2012-02-22 | 2021-03-02 | Merck Patent Gmbh | Liquid crystalline medium |
| EP2832734A4 (en) * | 2012-03-28 | 2015-08-26 | Takeda Pharmaceutical | HETEROCYCLIC COMPOUND |
| TW201406758A (zh) * | 2012-06-28 | 2014-02-16 | Daiichi Sankyo Co Ltd | 三環性化合物 |
| EP2872144A4 (en) * | 2012-07-11 | 2015-12-02 | Nimbus Iris Inc | IRAQ INHIBITOR AND USES THEREOF |
| EA201590644A1 (ru) * | 2012-09-24 | 2015-09-30 | Клермонт Спиде | Способ и система с управляемыми мобильным отправителем доступом к данным и удалением данных |
| WO2014050779A1 (ja) * | 2012-09-25 | 2014-04-03 | 第一三共株式会社 | Ｇｓｋ３阻害剤と抗ｄｒ５抗体の組み合わせ |
| WO2014139144A1 (en) | 2013-03-15 | 2014-09-18 | Agios Pharmaceuticals, Inc. | Therapeutic compounds and compositions |
| CA2908098A1 (en) * | 2013-03-15 | 2014-09-25 | Celgene Avilomics Research, Inc. | Mk2 inhibitors and uses thereof |
| WO2015050957A2 (en) | 2013-10-02 | 2015-04-09 | Treatments For Systemic Lupus Erythematosus | Treatments for systemic lupus erythematosus |
| WO2016032882A1 (en) | 2014-08-25 | 2016-03-03 | Stc.Unm | Inhibition of mk2 in the treatment of cancer |
| BR112017005266B1 (pt) | 2014-09-17 | 2022-11-01 | Celgene Car Llc | Compostos inibidores de mk2 e composição farmaceuticamente aceitável que os compreende |
| CN107406489A (zh) | 2015-01-08 | 2017-11-28 | 莫伊莱麦屈克斯公司 | Mk2抑制剂肽的制剂 |
| MX387359B (es) | 2017-03-16 | 2025-03-18 | Bristol Myers Squibb Co | Inhibidores de cinasa activada por mitógeno 2 (mk2), síntesis de los mismos, e intermediarios de los mismos. |
| US11098057B2 (en) | 2017-03-16 | 2021-08-24 | Celgene Car Llc | 9,10,11,12-tetrahydro-8H-[1,4]diazepino[5′,6′:4,5]thieno[3,2-F]quinolin-8-one compounds and uses thereof |
| WO2018170200A1 (en) | 2017-03-16 | 2018-09-20 | Celgene Car Llc | Heteroaryl compounds useful as mk2 inhibitors |
| WO2018170201A1 (en) | 2017-03-16 | 2018-09-20 | Celgene Car Llc | Deuterated analogs of mk2 inhibitors and uses thereof |
| WO2018170199A1 (en) | 2017-03-16 | 2018-09-20 | Celgene Car Llc | Forms and compositions of a mk2 inhibitor |
| WO2020236636A1 (en) | 2019-05-17 | 2020-11-26 | Celgene Car Llc | Methods of treating a mk2-mediated disorder |
| WO2022020562A1 (en) | 2020-07-24 | 2022-01-27 | Bristol-Myers Squibb Company | Methods of treating acute respiratory disorders |
-
2015
- 2015-09-16 BR BR112017005266-0A patent/BR112017005266B1/pt active IP Right Grant
- 2015-09-16 TW TW104130645A patent/TWI744217B/zh active
- 2015-09-16 EP EP21164056.0A patent/EP3912981A1/en active Pending
- 2015-09-16 US US14/856,311 patent/US9458175B2/en active Active
- 2015-09-16 RS RS20210725A patent/RS62017B1/sr unknown
- 2015-09-16 PT PT158429035T patent/PT3193611T/pt unknown
- 2015-09-16 DK DK15842903.5T patent/DK3193611T3/da active
- 2015-09-16 LT LTEP15842903.5T patent/LT3193611T/lt unknown
- 2015-09-16 AU AU2015317741A patent/AU2015317741B2/en active Active
- 2015-09-16 EA EA201790380A patent/EA037299B1/ru not_active IP Right Cessation
- 2015-09-16 MA MA40534A patent/MA40534B1/fr unknown
- 2015-09-16 CN CN201580058026.4A patent/CN106998692B/zh active Active
- 2015-09-16 SG SG10201902326XA patent/SG10201902326XA/en unknown
- 2015-09-16 CA CA2961607A patent/CA2961607C/en active Active
- 2015-09-16 WO PCT/US2015/050495 patent/WO2016044463A2/en not_active Ceased
- 2015-09-16 JP JP2017515845A patent/JP6556225B2/ja active Active
- 2015-09-16 KR KR1020177010439A patent/KR102457848B1/ko active Active
- 2015-09-16 SM SM20210311T patent/SMT202100311T1/it unknown
- 2015-09-16 HU HUE15842903A patent/HUE054347T2/hu unknown
- 2015-09-16 MX MX2017003359A patent/MX373341B/es active IP Right Grant
- 2015-09-16 PL PL15842903T patent/PL3193611T3/pl unknown
- 2015-09-16 SI SI201531617T patent/SI3193611T1/sl unknown
- 2015-09-16 SG SG11201701861RA patent/SG11201701861RA/en unknown
- 2015-09-16 HR HRP20210529TT patent/HRP20210529T1/hr unknown
- 2015-09-16 ES ES15842903T patent/ES2874561T3/es active Active
- 2015-09-16 EP EP15842903.5A patent/EP3193611B1/en active Active
-
2016
- 2016-09-29 US US15/280,157 patent/US9790235B2/en active Active
-
2017
- 2017-03-09 IL IL25105117A patent/IL251051B/en active IP Right Grant
- 2017-03-09 CL CL2017000576A patent/CL2017000576A1/es unknown
- 2017-03-14 MX MX2020005213A patent/MX2020005213A/es unknown
- 2017-03-16 SA SA517381115A patent/SA517381115B1/ar unknown
- 2017-04-04 CO CONC2017/0003279A patent/CO2017003279A2/es unknown
- 2017-04-13 EC ECIEPI201723281A patent/ECSP17023281A/es unknown
- 2017-10-13 US US15/782,995 patent/US10253040B1/en active Active
-
2019
- 2019-04-04 US US16/375,317 patent/US10577380B2/en active Active
- 2019-07-09 JP JP2019127476A patent/JP2019194236A/ja active Pending
-
2020
- 2020-02-27 US US16/802,654 patent/US11584757B2/en active Active
-
2021
- 2021-06-09 CY CY20211100504T patent/CY1124215T1/el unknown
-
2022
- 2022-03-16 JP JP2022041396A patent/JP7375072B2/ja active Active