|
US4221584A
(en)
*
|
1979-02-09 |
1980-09-09 |
Chevron Research Company |
Herbicidal and plant-growth-regulating N-(heterocyclyl)-methylacetanilides
|
|
US4735961A
(en)
*
|
1984-05-07 |
1988-04-05 |
Merck & Co., Inc. |
Oxazoles and thiazoles containing an aminohydroxypropoxyphenyl moiety
|
|
EP0805816B1
(en)
*
|
1995-01-27 |
2004-07-28 |
Novo Nordisk A/S |
Compounds with growth hormone releasing properties
|
|
JP4122056B2
(ja)
|
1995-04-06 |
2008-07-23 |
リジエネロン ファーマシューティカルズ,インコーポレイテッド |
Tie−2リガンド、その作製方法および使用方法
|
|
US20030040463A1
(en)
|
1996-04-05 |
2003-02-27 |
Wiegand Stanley J. |
TIE-2 ligands, methods of making and uses thereof
|
|
WO1998018914A1
(en)
|
1996-10-31 |
1998-05-07 |
Duke University |
Soluble tie2 receptor
|
|
US5980929A
(en)
|
1998-03-13 |
1999-11-09 |
Johns Hopkins University, School Of Medicine |
Use of a protein tyrosine kinase pathway inhibitor in the treatment of retinal ischmemia or ocular inflammation
|
|
US5919813C1
(en)
|
1998-03-13 |
2002-01-29 |
Univ Johns Hopkins Med |
Use of a protein tyrosine kinase pathway inhibitor in the treatment of diabetic retinopathy
|
|
JP2002540165A
(ja)
|
1999-03-26 |
2002-11-26 |
リジェネロン・ファーマシューティカルズ・インコーポレイテッド |
Tie2レセプターアクチベーターによる血管透過性の調節
|
|
US6455035B1
(en)
|
1999-03-26 |
2002-09-24 |
Regeneron Pharmaceuticals, Inc. |
Angiopoietins and methods of use thereof
|
|
RU2292221C2
(ru)
|
2000-06-23 |
2007-01-27 |
Шеринг Акциенгезельшафт |
Комбинации и композиции, которые оказывают воздействие на функцию систем vegf/ рецептор vegf и ангиопоэтин/рецептор tie (ii), и их применение
|
|
AU2002335085A1
(en)
|
2001-10-25 |
2003-05-06 |
Regeneron Pharmaceuticals, Inc. |
Angiopoietins and methods of use thereof
|
|
EP1480640B1
(en)
|
2002-02-25 |
2007-08-15 |
Eli Lilly And Company |
Peroxisome proliferator activated receptor modulators
|
|
WO2003084565A2
(en)
|
2002-04-08 |
2003-10-16 |
MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. |
Ve-ptp as regulator of ve-cadherin mediated processes or disorders
|
|
AU2003231098A1
(en)
|
2002-04-25 |
2003-11-10 |
University Of Connecticut Health Center |
Using heat shock proteins to improve the therapeutic benefit of a non-vaccine treatment modality
|
|
US7226755B1
(en)
|
2002-09-25 |
2007-06-05 |
The Procter & Gamble Company |
HPTPbeta as a target in treatment of angiogenesis mediated disorders
|
|
US7507568B2
(en)
|
2002-09-25 |
2009-03-24 |
The Proctor & Gamble Company |
Three dimensional coordinates of HPTPbeta
|
|
US6946479B2
(en)
|
2002-11-09 |
2005-09-20 |
The Procter & Gamble Company |
N-sulfonyl-4-methyleneamino-3-hydroxy-2-pyridones
|
|
US6930117B2
(en)
|
2002-11-09 |
2005-08-16 |
The Procter & Gamble Company |
N-alkyl-4-methyleneamino-3-hydroxy-2-pyridones
|
|
AR046510A1
(es)
|
2003-07-25 |
2005-12-14 |
Regeneron Pharma |
Composicion de un antagonista de vegf y un agente anti-proliferativo
|
|
US8298532B2
(en)
|
2004-01-16 |
2012-10-30 |
Regeneron Pharmaceuticals, Inc. |
Fusion polypeptides capable of activating receptors
|
|
DK3112352T3
(en)
|
2004-03-15 |
2019-01-28 |
Janssen Pharmaceutica Nv |
OPIOID RECEPTOR MODULATORS
|
|
WO2005089755A1
(en)
*
|
2004-03-18 |
2005-09-29 |
R-Tech Ueno, Ltd. |
Aqueous composition comprising thiazole derivative
|
|
US7771742B2
(en)
|
2004-04-30 |
2010-08-10 |
Allergan, Inc. |
Sustained release intraocular implants containing tyrosine kinase inhibitors and related methods
|
|
DK1771474T3
(da)
|
2004-07-20 |
2010-05-31 |
Genentech Inc |
Inhibitorer af angiopoitin-like 4 protein, kombinationer og anvendelser deraf
|
|
CA2581769C
(en)
|
2004-09-28 |
2014-03-11 |
Genexel-Sein, Inc. |
Methods of using chimeric coiled-coil molecule
|
|
PL1838733T3
(pl)
|
2004-12-21 |
2012-02-29 |
Medimmune Ltd |
Przeciwciała skierowane przeciwko angiopoetynie-2 i ich zastosowania
|
|
JO2787B1
(en)
|
2005-04-27 |
2014-03-15 |
امجين إنك, |
Alternative amide derivatives and methods of use
|
|
US7893040B2
(en)
|
2005-07-22 |
2011-02-22 |
Oculis Ehf |
Cyclodextrin nanotechnology for ophthalmic drug delivery
|
|
WO2007033216A2
(en)
|
2005-09-12 |
2007-03-22 |
Beth Israel Deaconess Medical Center |
Methods and compositions for the treatment and diagnosis of diseases characterized by vascular leak, hypotension, or a procoagulant state
|
|
US20090123474A1
(en)
|
2005-12-15 |
2009-05-14 |
Astrazeneca Ab |
Combination of angiopoietin-2 antagonist and of vegf-a, kdr and/or fltl antagonist for treating cancer
|
|
AU2007237096C1
(en)
|
2006-04-07 |
2012-12-13 |
EyePoint, Inc. |
Antibodies that bind human protein tyrosine phosphatase beta (HPTPbeta) and uses thereof
|
|
US20130023542A1
(en)
|
2006-06-27 |
2013-01-24 |
Aerpio Therapeutics Inc. |
Human protein tyrosine phosphatase inhibitors and methods of use
|
|
US7589212B2
(en)
|
2006-06-27 |
2009-09-15 |
Procter & Gamble Company |
Human protein tyrosine phosphatase inhibitors and methods of use
|
|
US7795444B2
(en)
|
2006-06-27 |
2010-09-14 |
Warner Chilcott Company |
Human protein tyrosine phosphatase inhibitors and methods of use
|
|
US8846685B2
(en)
|
2006-06-27 |
2014-09-30 |
Aerpio Therapeutics Inc. |
Human protein tyrosine phosphatase inhibitors and methods of use
|
|
US7622593B2
(en)
|
2006-06-27 |
2009-11-24 |
The Procter & Gamble Company |
Human protein tyrosine phosphatase inhibitors and methods of use
|
|
US8957022B2
(en)
|
2006-10-27 |
2015-02-17 |
Sunnybrook Health Sciences Centre |
Multimeric tie 2 agonists and uses thereof in stimulating angiogenesis
|
|
US8642067B2
(en)
|
2007-04-02 |
2014-02-04 |
Allergen, Inc. |
Methods and compositions for intraocular administration to treat ocular conditions
|
|
US11078262B2
(en)
|
2007-04-30 |
2021-08-03 |
Allergan, Inc. |
High viscosity macromolecular compositions for treating ocular conditions
|
|
US9403789B2
(en)
|
2008-02-21 |
2016-08-02 |
Sequoia Pharmaceuticals, Inc. |
Benzofuran-containing amino acid inhibitors of cytochrome P450
|
|
SG10201702247SA
(en)
*
|
2009-01-12 |
2017-04-27 |
Aerpio Therapeutics Inc |
Methods for treating vascular leak syndrome
|
|
US9096555B2
(en)
|
2009-01-12 |
2015-08-04 |
Aerpio Therapeutics, Inc. |
Methods for treating vascular leak syndrome
|
|
BRPI1008920A2
(pt)
|
2009-03-03 |
2015-08-25 |
Alcon Res Ltd |
Composição farmacêutica para liberação de compostos inibidores de receptor de tirosina quinase (rtki) para o olho
|
|
US20100227905A1
(en)
|
2009-03-03 |
2010-09-09 |
Alcon Research, Ltd. |
Pharmaceutical Composition for Delivery of Receptor Tyrosine Kinase Inhibiting (RTKi) Compounds to the Eye
|
|
TR201907783T4
(tr)
|
2009-07-06 |
2019-06-21 |
Aerpio Therapeutics Inc |
Benzosulfonamit türevleri, bileşimleri ve kanser hücrelerinin metastazının önlenmesinde kullanımları.
|
|
US8883832B2
(en)
|
2009-07-06 |
2014-11-11 |
Aerpio Therapeutics Inc. |
Compounds, compositions, and methods for preventing metastasis of cancer cells
|
|
AU2010314982B2
(en)
|
2009-11-06 |
2013-08-29 |
Aerpio Therapeutics Inc. |
Compositions and methods for treating colitis
|
|
US20110319455A1
(en)
|
2010-04-19 |
2011-12-29 |
Bruce Steven Klein |
Antifungal Treatment
|
|
ES2877629T3
(es)
|
2010-07-12 |
2021-11-17 |
Immunogenesis Inc |
Administración de profármacos activados por hipoxia y agentes antiangiogénicos para el tratamiento del cáncer
|
|
US20180092883A1
(en)
|
2010-10-07 |
2018-04-05 |
Aerpio Therapeutics, Inc. |
Phosphatase inhibitors for treating ocular diseases
|
|
EP2624916B1
(en)
|
2010-10-07 |
2018-01-17 |
Aerpio Therapeutics, Inc. |
Thiadiazole derivatives for use in the treatment of ocular edema
|
|
CN103249422A
(zh)
|
2010-12-02 |
2013-08-14 |
丸善制药株式会社 |
Tie2活化剂、血管内皮生长因子抑制剂、血管生成抑制剂、血管成熟剂、血管正常化剂及血管稳定剂、以及药物组合物
|
|
JP2014532072A
(ja)
|
2011-10-13 |
2014-12-04 |
エアピオ セラピューティックス, インコーポレイテッド |
眼疾患の治療
|
|
EP2766043A4
(en)
|
2011-10-13 |
2015-06-10 |
Aerpio Therapeutics Inc |
METHOD FOR THE TREATMENT OF CAPILLARY LECKSYNDROME AND CANCER
|
|
US20130190324A1
(en)
|
2011-12-23 |
2013-07-25 |
The Regents Of The University Of Colorado, A Body Corporate |
Topical ocular drug delivery
|
|
EP2836232A4
(en)
|
2012-04-13 |
2016-03-16 |
Univ Johns Hopkins |
TREATMENT OF ISCHEMIC RETINOPATHY
|
|
EA032192B1
(ru)
|
2012-07-13 |
2019-04-30 |
Роше Гликарт Аг |
Биспецифическое антитело к vegf/ang-2, нуклеиновая кислота, кодирующая это антитело, вектор, содержащий нуклеиновую кислоту, клетка-хозяин, способ получения биспецифического антитела и содержащая его фармацевтическая композиция
|
|
WO2014022455A1
(en)
|
2012-07-31 |
2014-02-06 |
The Board Of Regents Of The University Of Texas System |
Methods and compositions for in vivo induction of pancreatic beta cell formation
|
|
KR102235868B1
(ko)
|
2012-10-11 |
2021-04-07 |
아센디스 파마 옵탈몰로지 디비젼 에이/에스 |
안구 병태의 치료를 위한 vegf 중화 프로드럭
|
|
SG11201503637SA
(en)
|
2012-11-08 |
2015-06-29 |
Clearside Biomedical Inc |
Methods and devices for the treatment of ocular diseases in human subjects
|
|
US20150290235A1
(en)
|
2012-11-23 |
2015-10-15 |
Ab Science |
Use of small molecule inhibitors/activators in combination with (deoxy)nucleoside or (deoxy)nucleotide analogs for treatment of cancer and hematological malignancies or viral infections
|
|
KR20150129019A
(ko)
|
2013-03-15 |
2015-11-18 |
에르피오 세러퓨틱스 인코포레이티드 |
안과 질환을 치료하기 위한 조성물, 제형 및 방법
|
|
US20150050277A1
(en)
|
2013-03-15 |
2015-02-19 |
Aerpio Therapeutics Inc. |
Compositions and methods for treating ocular diseases
|
|
US10314882B2
(en)
|
2013-04-11 |
2019-06-11 |
Sunnybrook Research Institute |
Methods, uses and compositions of Tie2 agonists
|
|
WO2014203183A1
(en)
|
2013-06-20 |
2014-12-24 |
Novartis Ag |
Use of a vegf antagonist in treating macular edema
|
|
WO2014203182A1
(en)
|
2013-06-20 |
2014-12-24 |
Novartis Ag |
Use of a vegf antagonist in treating choroidal neovascularisation
|
|
US20160151410A1
(en)
|
2013-07-02 |
2016-06-02 |
The Trustees Of Columbia University In The City Of New York |
Clearance of bioactive lipids from membrane structures by cyclodextrins
|
|
BR112016000282A2
(pt)
|
2013-07-11 |
2017-12-12 |
Novartis Ag |
uso de antagonista de vegf em tratamento de retinopatia da prematuridade
|
|
KR20160029794A
(ko)
|
2013-07-11 |
2016-03-15 |
노파르티스 아게 |
소아 환자의 맥락망막 신생혈관성 및 투과성 장애의 치료에 있어서 vegf 길항제의 용도
|
|
US9828422B2
(en)
|
2013-07-29 |
2017-11-28 |
Samsung Electronics Co., Ltd. |
Anti-Ang2 antibody
|
|
US10617755B2
(en)
|
2013-08-30 |
2020-04-14 |
Genentech, Inc. |
Combination therapy for the treatment of glioblastoma
|
|
US20160252526A1
(en)
|
2013-10-01 |
2016-09-01 |
Sphingotec Gmbh |
A method for predicting the risk of getting a major adverse cardiac event
|
|
WO2015066426A2
(en)
|
2013-11-01 |
2015-05-07 |
Regeneron Pharmaceuticals, Inc. |
Angiopoietin-based interventions for treating cerebral malaria
|
|
CN106456614A
(zh)
|
2014-03-14 |
2017-02-22 |
爱尔皮奥治疗有限公司 |
HPTP‑β抑制剂
|
|
WO2015152416A1
(ja)
|
2014-04-04 |
2015-10-08 |
国立大学法人東北大学 |
眼圧降下剤
|
|
US9719135B2
(en)
|
2014-07-03 |
2017-08-01 |
Mannin Research Inc. |
Conditional angiopoietin-1/angiopoietin-2 double knock-out mice with defective ocular drainage system
|
|
US9539245B2
(en)
|
2014-08-07 |
2017-01-10 |
Aerpio Therapeutics, Inc. |
Combination of immunotherapies with activators of Tie-2
|
|
US20160082129A1
(en)
|
2014-09-24 |
2016-03-24 |
Aerpio Therapeutics, Inc. |
VE-PTP Extracellular Domain Antibodies Delivered by a Gene Therapy Vector
|
|
TWI738632B
(zh)
|
2014-11-07 |
2021-09-11 |
瑞士商諾華公司 |
穩定的含有高濃度抗vegf抗體之蛋白質溶液調配物
|
|
US20160144025A1
(en)
|
2014-11-25 |
2016-05-26 |
Regeneron Pharmaceuticals, Inc. |
Methods and formulations for treating vascular eye diseases
|