JP2018024670A5 - - Google Patents
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- JP2018024670A5 JP2018024670A5 JP2017154317A JP2017154317A JP2018024670A5 JP 2018024670 A5 JP2018024670 A5 JP 2018024670A5 JP 2017154317 A JP2017154317 A JP 2017154317A JP 2017154317 A JP2017154317 A JP 2017154317A JP 2018024670 A5 JP2018024670 A5 JP 2018024670A5
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- JP
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- Prior art keywords
- compound
- following formula
- salt
- formula
- following
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 150000001875 compounds Chemical class 0.000 claims 179
- 150000003839 salts Chemical class 0.000 claims 1
- 0 CC*C1=CCCC(NCc2ccccc2)=C1 Chemical compound CC*C1=CCCC(NCc2ccccc2)=C1 0.000 description 4
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AU2006906359 | 2006-11-15 | ||
| AU2006906359A AU2006906359A0 (en) | 2006-11-15 | Inhibitors of kinase activity | |
| US90151207P | 2007-02-14 | 2007-02-14 | |
| US60/901,512 | 2007-02-14 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015190233A Division JP2016041697A (ja) | 2006-11-15 | 2015-09-28 | キナーゼ活性の阻害剤 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2018024670A JP2018024670A (ja) | 2018-02-15 |
| JP2018024670A5 true JP2018024670A5 (enExample) | 2018-04-19 |
Family
ID=39401255
Family Applications (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009536562A Active JP5461189B2 (ja) | 2006-11-15 | 2007-11-15 | キナーゼ活性の阻害剤 |
| JP2013229858A Withdrawn JP2014065713A (ja) | 2006-11-15 | 2013-11-05 | キナーゼ活性の阻害剤 |
| JP2015078465A Active JP6444800B2 (ja) | 2006-11-15 | 2015-04-07 | キナーゼ活性の阻害剤 |
| JP2015190233A Withdrawn JP2016041697A (ja) | 2006-11-15 | 2015-09-28 | キナーゼ活性の阻害剤 |
| JP2017154317A Withdrawn JP2018024670A (ja) | 2006-11-15 | 2017-08-09 | キナーゼ活性の阻害剤 |
Family Applications Before (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009536562A Active JP5461189B2 (ja) | 2006-11-15 | 2007-11-15 | キナーゼ活性の阻害剤 |
| JP2013229858A Withdrawn JP2014065713A (ja) | 2006-11-15 | 2013-11-05 | キナーゼ活性の阻害剤 |
| JP2015078465A Active JP6444800B2 (ja) | 2006-11-15 | 2015-04-07 | キナーゼ活性の阻害剤 |
| JP2015190233A Withdrawn JP2016041697A (ja) | 2006-11-15 | 2015-09-28 | キナーゼ活性の阻害剤 |
Country Status (15)
| Country | Link |
|---|---|
| US (2) | US8461161B2 (enExample) |
| EP (3) | EP2848610B1 (enExample) |
| JP (5) | JP5461189B2 (enExample) |
| AU (1) | AU2007321719B2 (enExample) |
| CA (1) | CA2701959C (enExample) |
| CY (1) | CY1119528T1 (enExample) |
| DK (1) | DK2848610T3 (enExample) |
| ES (1) | ES2645947T3 (enExample) |
| HK (1) | HK1225722A1 (enExample) |
| HU (1) | HUE035868T2 (enExample) |
| LT (1) | LT2848610T (enExample) |
| PL (1) | PL2848610T3 (enExample) |
| PT (1) | PT2848610T (enExample) |
| SI (1) | SI2848610T1 (enExample) |
| WO (1) | WO2008058341A1 (enExample) |
Families Citing this family (58)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7977359B2 (en) | 2005-11-04 | 2011-07-12 | Amira Pharmaceuticals, Inc. | 5-lipdxygenase-activating protein (FLAP) inhibitors |
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| US8399666B2 (en) | 2005-11-04 | 2013-03-19 | Panmira Pharmaceuticals, Llc | 5-lipoxygenase-activating protein (FLAP) inhibitors |
| PL2848610T3 (pl) * | 2006-11-15 | 2018-01-31 | Ym Biosciences Australia Pty | Inhibitory aktywności kinazy |
| WO2008063888A2 (en) | 2006-11-22 | 2008-05-29 | Plexxikon, Inc. | Compounds modulating c-fms and/or c-kit activity and uses therefor |
| SG183036A1 (en) | 2007-07-17 | 2012-08-30 | Plexxikon Inc | Compounds and methods for kinase modulation, and indications therefor |
| TW200920369A (en) | 2007-10-26 | 2009-05-16 | Amira Pharmaceuticals Inc | 5-lipoxygenase activating protein (flap) inhibitor |
| WO2009095399A2 (en) | 2008-02-01 | 2009-08-06 | Akinion Pharmaceuticals Ab | Pyrazine derivatives and their use as protein kinase inhbitors |
| US8772495B2 (en) | 2008-05-23 | 2014-07-08 | Panmira Pharmaceuticals, Llc | 5-lipoxygenase-activating protein inhibitor |
| US8546431B2 (en) | 2008-10-01 | 2013-10-01 | Panmira Pharmaceuticals, Llc | 5-lipoxygenase-activating protein (FLAP) inhibitors |
| JP5727381B2 (ja) * | 2008-12-24 | 2015-06-03 | シンジェンタ リミテッド | アリールアミドの製造方法 |
| NZ594398A (en) | 2009-04-03 | 2014-03-28 | Plexxikon Inc | Propane-1-sulfonic acid (3-[5-(4-chloro-phenyl)-1h-pyrrol [2, 3-b] pyridine-3-carbonyl]-2,4-difluoro-phenyl} -amide compositions and uses thereof |
| EP2443255B1 (en) | 2009-06-19 | 2017-03-29 | Max-Delbrück-Centrum für Molekulare Medizin in der Helmholtz-Gemeinschaft | Csf1r-derived polynucleotides for medical use |
| US8329724B2 (en) | 2009-08-03 | 2012-12-11 | Hoffmann-La Roche Inc. | Process for the manufacture of pharmaceutically active compounds |
| US20120157439A1 (en) * | 2009-08-28 | 2012-06-21 | Genentech, Inc. | Raf inhibitor compounds and methods of use thereof |
| CA2780190C (en) | 2009-11-06 | 2020-05-05 | Plexxikon, Inc. | Compounds and methods for kinase modulation, and indications therefor |
| AU2010335231C1 (en) * | 2009-12-22 | 2015-04-16 | Merck Sharp & Dohme B.V. | Amino-heteroaryl derivatives as HCN blockers |
| US8247436B2 (en) | 2010-03-19 | 2012-08-21 | Novartis Ag | Pyridine and pyrazine derivative for the treatment of CF |
| CN102971322B (zh) | 2010-05-20 | 2016-02-17 | 阵列生物制药公司 | 作为trk激酶抑制剂的大环化合物 |
| AU2012214762B2 (en) | 2011-02-07 | 2015-08-13 | Plexxikon Inc. | Compounds and methods for kinase modulation, and indications therefor |
| AR085279A1 (es) | 2011-02-21 | 2013-09-18 | Plexxikon Inc | Formas solidas de {3-[5-(4-cloro-fenil)-1h-pirrolo[2,3-b]piridina-3-carbonil]-2,4-difluor-fenil}-amida del acido propano-1-sulfonico |
| GB201104153D0 (en) | 2011-03-11 | 2011-04-27 | Glaxo Group Ltd | Novel compounds |
| US9408952B2 (en) * | 2011-11-30 | 2016-08-09 | Abbott Cardiovascular Systems Inc. | Pediatric application of bioabsorbable polymer stents in infants and children with congenital heart defects |
| US8748097B1 (en) * | 2011-12-02 | 2014-06-10 | President And Fellows Of Harvard College | Identification of agents for treating calcium disorders and uses thereof |
| US9150570B2 (en) | 2012-05-31 | 2015-10-06 | Plexxikon Inc. | Synthesis of heterocyclic compounds |
| GB201211310D0 (en) * | 2012-06-26 | 2012-08-08 | Chroma Therapeutics Ltd | CSF-1R kinase inhibitors |
| WO2014110198A2 (en) * | 2013-01-10 | 2014-07-17 | Zisman Lawrence S | Therapeutic indications of kinase inhibitors |
| EP3007689B1 (en) * | 2013-01-10 | 2018-03-07 | Pulmokine, Inc. | Non-selective kinase inhibitors |
| US8937071B2 (en) | 2013-03-15 | 2015-01-20 | Glaxosmithkline Intellectual Property Development Limited | Compounds as rearranged during transfection (RET) inhibitors |
| HUE033423T2 (en) * | 2013-03-15 | 2017-11-28 | Glaxosmithkline Ip Dev Ltd | Pyridine derivatives as rearranged during transfection (ret) kinase inhibitors |
| CN103214413B (zh) * | 2013-03-22 | 2015-05-13 | 郑州泰基鸿诺药物科技有限公司 | 一种含杂环的三氟甲基酮化合物及其制备方法 |
| JP6483714B2 (ja) * | 2013-10-11 | 2019-03-13 | ローレンス エス． ジスマン， | 噴霧乾燥製剤 |
| CN105829285A (zh) | 2013-10-23 | 2016-08-03 | 中外制药株式会社 | 喹唑啉酮和异喹啉酮衍生物 |
| ES2901114T3 (es) | 2014-08-29 | 2022-03-21 | Tes Pharma S R L | Inhibidores de ácido alfa-amino-beta-carboximucónico semialdehído descarboxilasa |
| KR20170046180A (ko) | 2014-09-10 | 2017-04-28 | 글락소스미스클라인 인털렉츄얼 프로퍼티 디벨로프먼트 리미티드 | 형질감염 중 재배열 (ret) 억제제로서의 신규 화합물 |
| PT3191450T (pt) | 2014-09-10 | 2019-05-29 | Glaxosmithkline Ip Dev Ltd | Derivados de piridona como inibidores da quinase rearranjada durante a transfecção (ret) |
| CN104628659A (zh) * | 2015-01-27 | 2015-05-20 | 广西师范大学 | 具有抗肿瘤作用的吡嗪-芳基脲衍生物及其制备方法与应用 |
| CN108349969B (zh) | 2015-07-16 | 2022-05-10 | 阵列生物制药公司 | 作为RET激酶抑制剂的取代的吡唑并[1,5-a]吡啶化合物 |
| JOP20190077A1 (ar) | 2016-10-10 | 2019-04-09 | Array Biopharma Inc | مركبات بيرازولو [1، 5-a]بيريدين بها استبدال كمثبطات كيناز ret |
| TWI704148B (zh) | 2016-10-10 | 2020-09-11 | 美商亞雷生物製藥股份有限公司 | 作為ｒｅｔ激酶抑制劑之經取代吡唑并[1,5-a]吡啶化合物 |
| WO2018081567A1 (en) | 2016-10-27 | 2018-05-03 | Pulmokine, Inc. | Combination therapy for treating pulmonary hypertension |
| WO2018136663A1 (en) | 2017-01-18 | 2018-07-26 | Array Biopharma, Inc. | Ret inhibitors |
| ES2948194T3 (es) | 2017-01-18 | 2023-09-01 | Array Biopharma Inc | Compuestos de pirazolo[1,5-a]pirazina sustituida como inhibidores de la cinasa RET |
| JOP20190213A1 (ar) | 2017-03-16 | 2019-09-16 | Array Biopharma Inc | مركبات حلقية ضخمة كمثبطات لكيناز ros1 |
| TWI676482B (zh) * | 2017-03-23 | 2019-11-11 | 高雄醫學大學 | 盤基蛋白結構域受體１的抑制劑及活化劑及其用途 |
| US12133896B2 (en) | 2017-03-23 | 2024-11-05 | Kaohsiung Medical University | Methods for treating or alleviating a bone-loss related disease or condition by administering a nucleic acid encoding a discoidin domain receptor 1 (DDR1) protein |
| TWI791053B (zh) | 2017-10-10 | 2023-02-01 | 美商亞雷生物製藥股份有限公司 | 6-(2-羥基-2-甲基丙氧基)-4-(6-(6-((6-甲氧基吡啶-3-基)甲基)-3,6-二氮雜雙環[3.1.1]庚-3-基)吡啶-3-基)吡唑并[1,5-a]吡啶-3-甲腈之結晶形式及其醫藥組合物 |
| TWI812649B (zh) | 2017-10-10 | 2023-08-21 | 美商絡速藥業公司 | 6-(2-羥基-2-甲基丙氧基)-4-(6-(6-((6-甲氧基吡啶-3-基)甲基)-3,6-二氮雜雙環[3.1.1]庚-3-基)吡啶-3-基)吡唑并[1,5-a]吡啶-3-甲腈之調配物 |
| CN111971286B (zh) | 2018-01-18 | 2023-04-14 | 阿雷生物药品公司 | 作为RET激酶抑制剂的取代的吡咯并[2,3-d]嘧啶化合物 |
| CN111630054B (zh) | 2018-01-18 | 2023-05-09 | 奥瑞生物药品公司 | 作为RET激酶抑制剂的取代的吡唑并[3,4-d]嘧啶化合物 |
| US11472802B2 (en) | 2018-01-18 | 2022-10-18 | Array Biopharma Inc. | Substituted pyrazolyl[4,3-c]pyridine compounds as RET kinase inhibitors |
| JP2019138438A (ja) | 2018-02-15 | 2019-08-22 | 日本精工株式会社 | スピンドル装置 |
| WO2020055672A1 (en) | 2018-09-10 | 2020-03-19 | Array Biopharma Inc. | Fused heterocyclic compounds as ret kinase inhibitors |
| KR102329723B1 (ko) * | 2019-08-30 | 2021-11-23 | 한국과학기술연구원 | 단백질 키나아제 저해 활성을 갖는 신규한 피리미도[4,5-d]피리미딘-2-온 유도체 |
| KR102329720B1 (ko) * | 2019-08-30 | 2021-11-23 | 한국과학기술연구원 | 단백질 키나아제 저해 활성을 갖는 신규한 피리미도[4,5-d]피리미딘-2-온 유도체 |
| JP7761595B2 (ja) * | 2020-05-25 | 2025-10-28 | キエシ・フアルマチエウテイチ・ソチエタ・ペル・アチオニ | Ｄｄｒ阻害物質としてのベンジルアミン誘導体 |
| US20240150345A1 (en) * | 2021-01-22 | 2024-05-09 | Hibercell, Inc. | Gcn2 modulating compounds and uses thereof |
| US20240228462A1 (en) | 2021-05-07 | 2024-07-11 | Gb002, Inc. | Crystalline forms of n-{3-[(1s)-1-{[6-(3,4-dimethoxyphenyl)pyrazin-2- yl]amino}ethyl]phenyl}-5-methylpyridine-3-carboxamide and related products and methods |
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| JPS5488231A (en) * | 1977-12-22 | 1979-07-13 | Sumitomo Chem Co Ltd | 3-phenyloxymethylaniline derivative, its preparation, and herbicides consisting of it |
| DE3632329A1 (de) * | 1986-09-24 | 1988-03-31 | Bayer Ag | Substituierte phenylsulfonamide |
| ES2151652T3 (es) * | 1995-02-02 | 2001-01-01 | Smithkline Beecham Plc | Derivados de indol como antagonistas del receptor 5ht. |
| AU6526896A (en) * | 1995-07-22 | 1997-02-18 | Rhone-Poulenc Rorer Limited | Substituted aromatic compounds and their pharmaceutical use |
| WO1997008135A1 (de) | 1995-08-30 | 1997-03-06 | Bayer Aktiengesellschaft | Acylaminosalicylsäureamide und ihre verwendung als schädlingsbekämpfungsmittel |
| JPH09268169A (ja) * | 1996-04-01 | 1997-10-14 | Otsuka Chem Co Ltd | サリチル酸アニリド誘導体、それを有効成分として含む植物病害防除剤 |
| DE59811528D1 (de) * | 1997-04-04 | 2004-07-15 | Aventis Pharma Gmbh | Hypolipidämische Propanolaminderivate |
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| AU2003248245A1 (en) * | 2002-06-26 | 2004-01-19 | Ono Pharmaceutical Co., Ltd. | Remedies for diseases caused by vascular contraction or dilation |
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| CN103265495B (zh) * | 2005-12-29 | 2016-11-16 | 莱西肯医药有限公司 | 多环氨基酸衍生物及其使用方法 |
| US20070208053A1 (en) * | 2006-01-19 | 2007-09-06 | Arnold Lee D | Fused heterobicyclic kinase inhibitors |
| PL2848610T3 (pl) * | 2006-11-15 | 2018-01-31 | Ym Biosciences Australia Pty | Inhibitory aktywności kinazy |
-
2007
- 2007-11-15 PL PL14181447T patent/PL2848610T3/pl unknown
- 2007-11-15 AU AU2007321719A patent/AU2007321719B2/en active Active
- 2007-11-15 DK DK14181447.5T patent/DK2848610T3/da active
- 2007-11-15 EP EP14181447.5A patent/EP2848610B1/en active Active
- 2007-11-15 EP EP07815564A patent/EP2099774A4/en not_active Withdrawn
- 2007-11-15 PT PT141814475T patent/PT2848610T/pt unknown
- 2007-11-15 LT LTEP14181447.5T patent/LT2848610T/lt unknown
- 2007-11-15 HU HUE14181447A patent/HUE035868T2/en unknown
- 2007-11-15 EP EP15195727.1A patent/EP3048099A3/en not_active Ceased
- 2007-11-15 JP JP2009536562A patent/JP5461189B2/ja active Active
- 2007-11-15 ES ES14181447.5T patent/ES2645947T3/es active Active
- 2007-11-15 WO PCT/AU2007/001761 patent/WO2008058341A1/en not_active Ceased
- 2007-11-15 SI SI200731975T patent/SI2848610T1/en unknown
- 2007-11-15 CA CA2701959A patent/CA2701959C/en active Active
- 2007-11-15 US US12/515,250 patent/US8461161B2/en active Active
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2013
- 2013-01-22 US US13/747,343 patent/US9029386B2/en active Active
- 2013-11-05 JP JP2013229858A patent/JP2014065713A/ja not_active Withdrawn
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2015
- 2015-04-07 JP JP2015078465A patent/JP6444800B2/ja active Active
- 2015-09-28 JP JP2015190233A patent/JP2016041697A/ja not_active Withdrawn
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2016
- 2016-12-07 HK HK16113953.0A patent/HK1225722A1/en unknown
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2017
- 2017-08-09 JP JP2017154317A patent/JP2018024670A/ja not_active Withdrawn
- 2017-11-02 CY CY20171101143T patent/CY1119528T1/el unknown