JP2018024670A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2018024670A5 JP2018024670A5 JP2017154317A JP2017154317A JP2018024670A5 JP 2018024670 A5 JP2018024670 A5 JP 2018024670A5 JP 2017154317 A JP2017154317 A JP 2017154317A JP 2017154317 A JP2017154317 A JP 2017154317A JP 2018024670 A5 JP2018024670 A5 JP 2018024670A5
- Authority
- JP
- Japan
- Prior art keywords
- compound
- following formula
- salt
- formula
- following
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 150000001875 compounds Chemical class 0.000 claims 179
- 150000003839 salts Chemical class 0.000 claims 1
- 0 CC*C1=CCCC(NCc2ccccc2)=C1 Chemical compound CC*C1=CCCC(NCc2ccccc2)=C1 0.000 description 4
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AU2006906359 | 2006-11-15 | ||
| AU2006906359A AU2006906359A0 (en) | 2006-11-15 | Inhibitors of kinase activity | |
| US90151207P | 2007-02-14 | 2007-02-14 | |
| US60/901,512 | 2007-02-14 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015190233A Division JP2016041697A (ja) | 2006-11-15 | 2015-09-28 | キナーゼ活性の阻害剤 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2018024670A JP2018024670A (ja) | 2018-02-15 |
| JP2018024670A5 true JP2018024670A5 (enExample) | 2018-04-19 |
Family
ID=39401255
Family Applications (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009536562A Active JP5461189B2 (ja) | 2006-11-15 | 2007-11-15 | キナーゼ活性の阻害剤 |
| JP2013229858A Withdrawn JP2014065713A (ja) | 2006-11-15 | 2013-11-05 | キナーゼ活性の阻害剤 |
| JP2015078465A Active JP6444800B2 (ja) | 2006-11-15 | 2015-04-07 | キナーゼ活性の阻害剤 |
| JP2015190233A Withdrawn JP2016041697A (ja) | 2006-11-15 | 2015-09-28 | キナーゼ活性の阻害剤 |
| JP2017154317A Withdrawn JP2018024670A (ja) | 2006-11-15 | 2017-08-09 | キナーゼ活性の阻害剤 |
Family Applications Before (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009536562A Active JP5461189B2 (ja) | 2006-11-15 | 2007-11-15 | キナーゼ活性の阻害剤 |
| JP2013229858A Withdrawn JP2014065713A (ja) | 2006-11-15 | 2013-11-05 | キナーゼ活性の阻害剤 |
| JP2015078465A Active JP6444800B2 (ja) | 2006-11-15 | 2015-04-07 | キナーゼ活性の阻害剤 |
| JP2015190233A Withdrawn JP2016041697A (ja) | 2006-11-15 | 2015-09-28 | キナーゼ活性の阻害剤 |
Country Status (15)
| Country | Link |
|---|---|
| US (2) | US8461161B2 (enExample) |
| EP (3) | EP2099774A4 (enExample) |
| JP (5) | JP5461189B2 (enExample) |
| AU (1) | AU2007321719B2 (enExample) |
| CA (1) | CA2701959C (enExample) |
| CY (1) | CY1119528T1 (enExample) |
| DK (1) | DK2848610T3 (enExample) |
| ES (1) | ES2645947T3 (enExample) |
| HK (1) | HK1225722A1 (enExample) |
| HU (1) | HUE035868T2 (enExample) |
| LT (1) | LT2848610T (enExample) |
| PL (1) | PL2848610T3 (enExample) |
| PT (1) | PT2848610T (enExample) |
| SI (1) | SI2848610T1 (enExample) |
| WO (1) | WO2008058341A1 (enExample) |
Families Citing this family (58)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2431927B (en) | 2005-11-04 | 2010-03-17 | Amira Pharmaceuticals Inc | 5-Lipoxygenase-activating protein (FLAP) inhibitors |
| US7977359B2 (en) | 2005-11-04 | 2011-07-12 | Amira Pharmaceuticals, Inc. | 5-lipdxygenase-activating protein (FLAP) inhibitors |
| US8399666B2 (en) | 2005-11-04 | 2013-03-19 | Panmira Pharmaceuticals, Llc | 5-lipoxygenase-activating protein (FLAP) inhibitors |
| EP2099774A4 (en) * | 2006-11-15 | 2010-11-24 | Ym Biosciences Australia Pty L | INHIBITORS OF KINASEACTIVITY |
| WO2008063888A2 (en) | 2006-11-22 | 2008-05-29 | Plexxikon, Inc. | Compounds modulating c-fms and/or c-kit activity and uses therefor |
| US20100190777A1 (en) | 2007-07-17 | 2010-07-29 | Plexxikon Inc. | Compounds and methods for kinase modulation, and indications therefor |
| TW200920369A (en) | 2007-10-26 | 2009-05-16 | Amira Pharmaceuticals Inc | 5-lipoxygenase activating protein (flap) inhibitor |
| US8436171B2 (en) | 2008-02-01 | 2013-05-07 | Akinion Pharmaceuticals Ab | Amino substituted pyrazines as inhibitors or protein kinases |
| EA019819B1 (ru) | 2008-05-23 | 2014-06-30 | ПАНМИРА ФАРМАСЬЮТИКАЛЗ, ЭлЭлСи | Кристаллическая полиморфная форма с ингибитора белка, активирующего 5-липоксигеназу, фармацевтическая композиция на ее основе и применение в лечении |
| US8546431B2 (en) | 2008-10-01 | 2013-10-01 | Panmira Pharmaceuticals, Llc | 5-lipoxygenase-activating protein (FLAP) inhibitors |
| JP2012513961A (ja) * | 2008-12-24 | 2012-06-21 | シンジェンタ リミテッド | 殺菌剤の調製方法 |
| PT2414356E (pt) | 2009-04-03 | 2015-11-23 | Hoffmann La Roche | Composições de {3-[5-(4-cloro-fenil)-1h-pirrol[2,3-b]piridin-3-carbonil]-2,4-difluoro-fenil}-amida do ácido propano-1-sulfónico e utilizações das mesmas |
| WO2010145839A2 (en) | 2009-06-19 | 2010-12-23 | Max-Delbrück-Centrum Für Molekulare Medizin Berlin-Buch | Polynucleotides for medical use |
| US8329724B2 (en) | 2009-08-03 | 2012-12-11 | Hoffmann-La Roche Inc. | Process for the manufacture of pharmaceutically active compounds |
| EP2470538A1 (en) * | 2009-08-28 | 2012-07-04 | Array Biopharma, Inc. | Raf inhibitor compounds and methods of use thereof |
| CA2780190C (en) | 2009-11-06 | 2020-05-05 | Plexxikon, Inc. | Compounds and methods for kinase modulation, and indications therefor |
| BR112012015170A8 (pt) * | 2009-12-22 | 2017-12-26 | Msd Oss Bv | Derivado de amino-heteroarila, composição farmacêutica, uso de um derivado de amino-heteroarila, e, método para tratamento de dor |
| US8247436B2 (en) | 2010-03-19 | 2012-08-21 | Novartis Ag | Pyridine and pyrazine derivative for the treatment of CF |
| SMT201700372T1 (it) | 2010-05-20 | 2017-09-07 | Array Biopharma Inc | Composti macrociclici come inibitori di trk chinasi |
| PE20141360A1 (es) | 2011-02-07 | 2014-10-13 | Plexxikon Inc | Compuestos y metodos para la modulacion de quinasas e indicaciones para los mismos. |
| TWI558702B (zh) | 2011-02-21 | 2016-11-21 | 普雷辛肯公司 | 醫藥活性物質的固態形式 |
| GB201104153D0 (en) | 2011-03-11 | 2011-04-27 | Glaxo Group Ltd | Novel compounds |
| US9408952B2 (en) * | 2011-11-30 | 2016-08-09 | Abbott Cardiovascular Systems Inc. | Pediatric application of bioabsorbable polymer stents in infants and children with congenital heart defects |
| US8748097B1 (en) * | 2011-12-02 | 2014-06-10 | President And Fellows Of Harvard College | Identification of agents for treating calcium disorders and uses thereof |
| US9150570B2 (en) | 2012-05-31 | 2015-10-06 | Plexxikon Inc. | Synthesis of heterocyclic compounds |
| GB201211310D0 (en) | 2012-06-26 | 2012-08-08 | Chroma Therapeutics Ltd | CSF-1R kinase inhibitors |
| DK3007689T3 (en) | 2013-01-10 | 2018-06-14 | Pulmokine Inc | NON-SELECTIVE KINASE INHIBITORS |
| US20150352111A1 (en) * | 2013-01-10 | 2015-12-10 | Pulmokine, Inc. | Therapeutic Indications of Kinase Inhibitors |
| ES2616655T3 (es) * | 2013-03-15 | 2017-06-13 | Glaxosmithkline Intellectual Property Development Limited | Derivados de piridina como inhibidores de quinasa reorganizada durante la transfección (RET) |
| US8937071B2 (en) | 2013-03-15 | 2015-01-20 | Glaxosmithkline Intellectual Property Development Limited | Compounds as rearranged during transfection (RET) inhibitors |
| CN103214413B (zh) * | 2013-03-22 | 2015-05-13 | 郑州泰基鸿诺药物科技有限公司 | 一种含杂环的三氟甲基酮化合物及其制备方法 |
| CN106132403B (zh) * | 2013-10-11 | 2020-04-28 | 普尔莫凯恩股份有限公司 | 喷雾干燥制剂 |
| US10005739B2 (en) | 2013-10-23 | 2018-06-26 | Chugai Seiyaku Kabushiki Kaisha | Quinazolinone and isoquinolinone derivative |
| KR102431436B1 (ko) | 2014-08-29 | 2022-08-10 | 테스 파마 에스.알.엘. | α-아미노-β-카복시뮤콘산 세미알데히드 데카복실라제의 억제제 |
| WO2016037578A1 (en) | 2014-09-10 | 2016-03-17 | Glaxosmithkline Intellectual Property Development Limited | Novel compounds as rearranged during transfection (ret) inhibitors |
| MA40581A (fr) | 2014-09-10 | 2019-04-10 | Glaxosmithkline Ip Dev Ltd | Dérivés pyridone utilisés comme inhibiteurs de la kinase réarrangée au cours de la transfection (ret) |
| CN104628659A (zh) * | 2015-01-27 | 2015-05-20 | 广西师范大学 | 具有抗肿瘤作用的吡嗪-芳基脲衍生物及其制备方法与应用 |
| HRP20210177T1 (hr) | 2015-07-16 | 2021-03-19 | Array Biopharma, Inc. | Supstituirani spojevi pirazolo[1,5-a]piridina kao inhibitori ret kinaze |
| TWI704148B (zh) | 2016-10-10 | 2020-09-11 | 美商亞雷生物製藥股份有限公司 | 作為ｒｅｔ激酶抑制劑之經取代吡唑并[1,5-a]吡啶化合物 |
| JOP20190077A1 (ar) | 2016-10-10 | 2019-04-09 | Array Biopharma Inc | مركبات بيرازولو [1، 5-a]بيريدين بها استبدال كمثبطات كيناز ret |
| AU2017348354B2 (en) | 2016-10-27 | 2023-06-15 | Pulmokine, Inc. | Combination therapy for treating pulmonary hypertension |
| WO2018136663A1 (en) | 2017-01-18 | 2018-07-26 | Array Biopharma, Inc. | Ret inhibitors |
| CN110267960B (zh) | 2017-01-18 | 2022-04-26 | 阿雷生物药品公司 | 作为RET激酶抑制剂的取代的吡唑并[1,5-a]吡嗪化合物 |
| JOP20190213A1 (ar) | 2017-03-16 | 2019-09-16 | Array Biopharma Inc | مركبات حلقية ضخمة كمثبطات لكيناز ros1 |
| US12133896B2 (en) | 2017-03-23 | 2024-11-05 | Kaohsiung Medical University | Methods for treating or alleviating a bone-loss related disease or condition by administering a nucleic acid encoding a discoidin domain receptor 1 (DDR1) protein |
| TWI676482B (zh) * | 2017-03-23 | 2019-11-11 | 高雄醫學大學 | 盤基蛋白結構域受體１的抑制劑及活化劑及其用途 |
| TWI791053B (zh) | 2017-10-10 | 2023-02-01 | 美商亞雷生物製藥股份有限公司 | 6-(2-羥基-2-甲基丙氧基)-4-(6-(6-((6-甲氧基吡啶-3-基)甲基)-3,6-二氮雜雙環[3.1.1]庚-3-基)吡啶-3-基)吡唑并[1,5-a]吡啶-3-甲腈之結晶形式及其醫藥組合物 |
| TWI876442B (zh) | 2017-10-10 | 2025-03-11 | 美商絡速藥業公司 | 6-(2-羥基-2-甲基丙氧基)-4-(6-(6-((6-甲氧基吡啶-3-基)甲基)-3,6-二氮雜雙環[3.1.1]庚-3-基)吡啶-3-基)吡唑并[1,5-a]吡啶-3-甲腈之調配物 |
| CN111630054B (zh) | 2018-01-18 | 2023-05-09 | 奥瑞生物药品公司 | 作为RET激酶抑制剂的取代的吡唑并[3,4-d]嘧啶化合物 |
| CN111971286B (zh) | 2018-01-18 | 2023-04-14 | 阿雷生物药品公司 | 作为RET激酶抑制剂的取代的吡咯并[2,3-d]嘧啶化合物 |
| CA3087972C (en) | 2018-01-18 | 2023-01-10 | Array Biopharma Inc. | Substituted pyrazolyl[4,3-c]pyridinecompounds as ret kinase inhibitors |
| JP2019138438A (ja) | 2018-02-15 | 2019-08-22 | 日本精工株式会社 | スピンドル装置 |
| US11964988B2 (en) | 2018-09-10 | 2024-04-23 | Array Biopharma Inc. | Fused heterocyclic compounds as RET kinase inhibitors |
| KR102329720B1 (ko) | 2019-08-30 | 2021-11-23 | 한국과학기술연구원 | 단백질 키나아제 저해 활성을 갖는 신규한 피리미도[4,5-d]피리미딘-2-온 유도체 |
| KR102329723B1 (ko) * | 2019-08-30 | 2021-11-23 | 한국과학기술연구원 | 단백질 키나아제 저해 활성을 갖는 신규한 피리미도[4,5-d]피리미딘-2-온 유도체 |
| US20230227447A1 (en) * | 2020-05-25 | 2023-07-20 | Chiesi Farmaceutici S.P.A. | Benzylamine derivatives as ddrs inhibitors |
| WO2022159745A1 (en) * | 2021-01-22 | 2022-07-28 | Hibercell, Inc. | Gcn2 modulating compounds and uses thereof |
| KR20240006513A (ko) | 2021-05-07 | 2024-01-15 | 지비002 인코포레이티드 | N-3-[(1s)-1-[6-(3,4-다이메톡시페닐)피라진-2-일]아미노에틸]페닐-5-메틸피리딘-3-카복사마이드의 결정질 형태 및 관련 생성물 및 방법 |
Family Cites Families (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5488231A (en) * | 1977-12-22 | 1979-07-13 | Sumitomo Chem Co Ltd | 3-phenyloxymethylaniline derivative, its preparation, and herbicides consisting of it |
| DE3632329A1 (de) | 1986-09-24 | 1988-03-31 | Bayer Ag | Substituierte phenylsulfonamide |
| DK0808312T3 (da) | 1995-02-02 | 2001-02-12 | Smithkline Beecham Plc | Indolderivater som 5-HT-receptorantagonist |
| AU6526896A (en) * | 1995-07-22 | 1997-02-18 | Rhone-Poulenc Rorer Limited | Substituted aromatic compounds and their pharmaceutical use |
| WO1997008135A1 (de) | 1995-08-30 | 1997-03-06 | Bayer Aktiengesellschaft | Acylaminosalicylsäureamide und ihre verwendung als schädlingsbekämpfungsmittel |
| JPH09268169A (ja) | 1996-04-01 | 1997-10-14 | Otsuka Chem Co Ltd | サリチル酸アニリド誘導体、それを有効成分として含む植物病害防除剤 |
| DE59811528D1 (de) * | 1997-04-04 | 2004-07-15 | Aventis Pharma Gmbh | Hypolipidämische Propanolaminderivate |
| AUPO863197A0 (en) * | 1997-08-18 | 1997-09-11 | Fujisawa Pharmaceutical Co., Ltd. | Novel derivatives |
| US6143780A (en) * | 1999-09-17 | 2000-11-07 | Uniroyal Chemical Company, Inc. | N-arylmethylthioanilide compounds useful for the inhibition of the replication of HIV |
| US6462092B1 (en) * | 1999-09-23 | 2002-10-08 | G.D. Searle & Co. | Use of substituted N, N-disubstituted reverse aminoalcohol compounds for inhibiting cholesteryl ester transfer protein activity |
| US6514964B1 (en) | 1999-09-27 | 2003-02-04 | Amgen Inc. | Fused cycloheptane and fused azacycloheptane compounds and their methods of use |
| HN2001000008A (es) | 2000-01-21 | 2003-12-11 | Inc Agouron Pharmaceuticals | Compuesto de amida y composiciones farmaceuticas para inhibir proteinquinasas, y su modo de empleo |
| US6825198B2 (en) * | 2001-06-21 | 2004-11-30 | Pfizer Inc | 5-HT receptor ligands and uses thereof |
| CA2462289C (en) * | 2001-10-04 | 2010-02-23 | Nicholas D. Cosford | Heteroaryl substituted tetrazole modulators of metabotropic glutamate receptor-5 |
| AUPS251502A0 (en) * | 2002-05-23 | 2002-06-13 | Cytopia Pty Ltd | Protein kinase inhibitors |
| NZ537156A (en) | 2002-05-23 | 2007-06-29 | Cytopia Pty Ltd | Kinase inhibitors |
| DE60317198T2 (de) | 2002-05-23 | 2008-12-04 | Cytopia Research Pty. Ltd., Richmond | Proteinkinaseinhibitoren |
| AU2003248245A1 (en) | 2002-06-26 | 2004-01-19 | Ono Pharmaceutical Co., Ltd. | Remedies for diseases caused by vascular contraction or dilation |
| EP1545523A1 (en) * | 2002-07-03 | 2005-06-29 | Astex Technology Limited | 3-&-grave;(HETERO) ARYLMETHOXY ! PYRIDINES AND THEIR ANALOGUES ASP38 MAP KINASE INHIBITORS |
| AU2003251944B2 (en) * | 2002-07-15 | 2008-06-26 | Myriad Genetics, Inc. | Compounds, compositions, and methods employing same |
| AU2002953255A0 (en) | 2002-12-11 | 2003-01-02 | Cytopia Research Pty Ltd | Protein kinase inhibitors |
| CN101328135A (zh) * | 2003-02-07 | 2008-12-24 | 小野药品工业株式会社 | 羧酸化合物 |
| WO2005002673A1 (en) * | 2003-07-03 | 2005-01-13 | Astex Therapeutics Limited | Raf kinase inhibitors |
| DE602004025258D1 (de) * | 2003-08-06 | 2010-03-11 | Vertex Pharma | Aminotriazol-verbindungen als proteinkinase-hemmer |
| WO2005040152A1 (en) * | 2003-10-20 | 2005-05-06 | E.I. Dupont De Nemours And Company | Heteroyclylphenyl-and heterocyclylpyridyl-substituted azolecarboxamides as herbicides |
| CN1890218B (zh) * | 2003-12-03 | 2011-08-03 | Ym生物科学澳大利亚私人有限公司 | 微管蛋白抑制剂 |
| KR101164541B1 (ko) * | 2004-01-12 | 2012-07-10 | 와이엠 바이오사이언시즈 오스트레일리아 피티와이 엘티디 | 선택적 키나제 저해제 |
| EP1789393A2 (en) * | 2004-07-30 | 2007-05-30 | GPC Biotech AG | Pyridinylamines |
| JP2006111553A (ja) | 2004-10-13 | 2006-04-27 | Dainippon Sumitomo Pharma Co Ltd | スルホニルオキシインドール誘導体及びそれを含有する医薬組成物 |
| EP1831170A4 (en) * | 2004-12-14 | 2009-10-14 | Astrazeneca Ab | SUBSTITUTED AMINOPYRIDINES AND THEIR USE |
| EP1838320B1 (en) * | 2005-01-07 | 2014-07-16 | Emory University | Cxcr4 antagonists for the treatment of medical disorders |
| US7723345B2 (en) * | 2005-12-29 | 2010-05-25 | Lexicon Pharmaceuticals, Inc. | Multicyclic amino acid derivatives and methods of their use |
| US20070208053A1 (en) | 2006-01-19 | 2007-09-06 | Arnold Lee D | Fused heterobicyclic kinase inhibitors |
| EP2099774A4 (en) | 2006-11-15 | 2010-11-24 | Ym Biosciences Australia Pty L | INHIBITORS OF KINASEACTIVITY |
-
2007
- 2007-11-15 EP EP07815564A patent/EP2099774A4/en not_active Withdrawn
- 2007-11-15 WO PCT/AU2007/001761 patent/WO2008058341A1/en not_active Ceased
- 2007-11-15 ES ES14181447.5T patent/ES2645947T3/es active Active
- 2007-11-15 LT LTEP14181447.5T patent/LT2848610T/lt unknown
- 2007-11-15 PL PL14181447T patent/PL2848610T3/pl unknown
- 2007-11-15 SI SI200731975T patent/SI2848610T1/en unknown
- 2007-11-15 PT PT141814475T patent/PT2848610T/pt unknown
- 2007-11-15 JP JP2009536562A patent/JP5461189B2/ja active Active
- 2007-11-15 EP EP14181447.5A patent/EP2848610B1/en active Active
- 2007-11-15 AU AU2007321719A patent/AU2007321719B2/en active Active
- 2007-11-15 EP EP15195727.1A patent/EP3048099A3/en not_active Ceased
- 2007-11-15 CA CA2701959A patent/CA2701959C/en active Active
- 2007-11-15 HU HUE14181447A patent/HUE035868T2/en unknown
- 2007-11-15 US US12/515,250 patent/US8461161B2/en active Active
- 2007-11-15 DK DK14181447.5T patent/DK2848610T3/da active
-
2013
- 2013-01-22 US US13/747,343 patent/US9029386B2/en active Active
- 2013-11-05 JP JP2013229858A patent/JP2014065713A/ja not_active Withdrawn
-
2015
- 2015-04-07 JP JP2015078465A patent/JP6444800B2/ja active Active
- 2015-09-28 JP JP2015190233A patent/JP2016041697A/ja not_active Withdrawn
-
2016
- 2016-12-07 HK HK16113953.0A patent/HK1225722A1/en unknown
-
2017
- 2017-08-09 JP JP2017154317A patent/JP2018024670A/ja not_active Withdrawn
- 2017-11-02 CY CY20171101143T patent/CY1119528T1/el unknown