JP2015522045A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2015522045A5 JP2015522045A5 JP2015520844A JP2015520844A JP2015522045A5 JP 2015522045 A5 JP2015522045 A5 JP 2015522045A5 JP 2015520844 A JP2015520844 A JP 2015520844A JP 2015520844 A JP2015520844 A JP 2015520844A JP 2015522045 A5 JP2015522045 A5 JP 2015522045A5
- Authority
- JP
- Japan
- Prior art keywords
- compounds
- formula
- compound represented
- following groups
- groups
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001875 compounds Chemical class 0.000 claims 2
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261669843P | 2012-07-10 | 2012-07-10 | |
| EP12175660.5 | 2012-07-10 | ||
| US61/669,843 | 2012-07-10 | ||
| EP12175660 | 2012-07-10 | ||
| PCT/EP2013/001950 WO2014008992A1 (en) | 2012-07-10 | 2013-07-03 | Pyrimidine pyrazolyl derivatives |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015522045A JP2015522045A (ja) | 2015-08-03 |
| JP2015522045A5 true JP2015522045A5 (enExample) | 2017-07-06 |
| JP6189434B2 JP6189434B2 (ja) | 2017-08-30 |
Family
ID=49915426
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015520844A Active JP6189434B2 (ja) | 2012-07-10 | 2013-07-03 | ピリミジンピラゾリル誘導体 |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US9216991B2 (enExample) |
| EP (1) | EP2872501B1 (enExample) |
| JP (1) | JP6189434B2 (enExample) |
| KR (1) | KR20150033716A (enExample) |
| CN (1) | CN104662014B (enExample) |
| AU (1) | AU2013289615B2 (enExample) |
| BR (1) | BR112015000399A2 (enExample) |
| CA (1) | CA2878621C (enExample) |
| DK (1) | DK2872501T3 (enExample) |
| ES (1) | ES2589558T3 (enExample) |
| HU (1) | HUE029559T2 (enExample) |
| IL (1) | IL236542B (enExample) |
| MX (1) | MX2015000129A (enExample) |
| PT (1) | PT2872501T (enExample) |
| RU (1) | RU2015104123A (enExample) |
| SG (1) | SG11201500005SA (enExample) |
| WO (1) | WO2014008992A1 (enExample) |
| ZA (1) | ZA201500917B (enExample) |
Families Citing this family (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2728403T3 (es) * | 2014-01-09 | 2019-10-24 | Merck Patent Gmbh | Derivados de pirimidin pirazolilo y su uso como inhibidores de IRAK |
| BR112016021641A2 (pt) * | 2014-03-27 | 2017-08-15 | Eicosis Llc | Potentes inibidores da epóxido hidrolase solúveis |
| LT3221306T (lt) * | 2014-11-20 | 2020-03-10 | Merck Patent Gmbh | Heteroarilo junginiai, kaip irak inhibitoriai ir jų panaudojimas |
| CN105153211B (zh) * | 2015-09-22 | 2017-02-01 | 上海晋鲁医药科技有限公司 | 一种合成1‑(N‑Boc‑4‑哌啶)‑4‑吡唑硼酸频哪醇酯的方法 |
| US10435396B2 (en) | 2016-03-03 | 2019-10-08 | Bayer Pharma Aktiegesellschaft | 2-substituted indazoles, methods for producing same, pharmaceutical preparations that contain same, and use of same to produce drugs |
| TW202340194A (zh) | 2017-02-16 | 2023-10-16 | 美商基利科學股份有限公司 | 吡咯并[1,2-b]嗒𠯤衍生物 |
| EP3596086A4 (en) | 2017-03-16 | 2020-12-16 | Celgene CAR LLC | MK2 INHIBITORS, THEIR SYNTHESIS AND THEIR INTERMEDIARIES |
| CN106967073A (zh) * | 2017-04-24 | 2017-07-21 | 刘双伟 | 一种治疗类风湿性关节炎的药物 |
| CN106946891B (zh) * | 2017-05-08 | 2018-07-13 | 宿州市徽腾知识产权咨询有限公司 | 一种用于治疗类风湿性关节炎的药物 |
| MX2020003190A (es) | 2017-09-22 | 2020-11-11 | Kymera Therapeutics Inc | Degradadores de proteinas y usos de los mismos. |
| WO2019060693A1 (en) | 2017-09-22 | 2019-03-28 | Kymera Therapeutics, Inc. | CRBN LIGANDS AND USES THEREOF |
| WO2019111218A1 (en) | 2017-12-08 | 2019-06-13 | Cadila Healthcare Limited | Novel heterocyclic compounds as irak4 inhibitors |
| IL315310A (en) | 2017-12-26 | 2024-10-01 | Kymera Therapeutics Inc | Irak degraders and uses thereof |
| EP3737666A4 (en) | 2018-01-12 | 2022-01-05 | Kymera Therapeutics, Inc. | PROTEIN DEGRADATION AGENTS AND ASSOCIATED USES |
| US11512080B2 (en) | 2018-01-12 | 2022-11-29 | Kymera Therapeutics, Inc. | CRBN ligands and uses thereof |
| US11292792B2 (en) | 2018-07-06 | 2022-04-05 | Kymera Therapeutics, Inc. | Tricyclic CRBN ligands and uses thereof |
| US12454520B2 (en) | 2018-07-06 | 2025-10-28 | Kymera Therapeutics, Inc. | Protein degraders and uses thereof |
| TWI721483B (zh) | 2018-07-13 | 2021-03-11 | 美商基利科學股份有限公司 | 吡咯并[1,2-b]嗒𠯤衍生物 |
| CN113226321B (zh) * | 2018-10-26 | 2024-12-17 | 阿利安制药有限责任公司 | 吡唑基化合物及其使用方法 |
| AU2019389174A1 (en) | 2018-11-30 | 2021-07-01 | Kymera Therapeutics, Inc. | Irak degraders and uses thereof |
| PH12022500002A1 (en) | 2019-06-28 | 2023-04-03 | Kymera Therapeutics Inc | Irak degraders and uses thereof |
| US12558427B2 (en) | 2019-07-17 | 2026-02-24 | Kymera Therapeutics, Inc. | IRAK degraders and uses thereof |
| EP4061821B1 (en) * | 2019-11-20 | 2025-08-06 | F. Hoffmann-La Roche AG | Spiro(isobenzofuranazetidine) compounds for the treatment of autoimmune disease |
| WO2021119159A1 (en) | 2019-12-10 | 2021-06-17 | Kymera Therapeutics, Inc. | Irak degraders and uses thereof |
| CA3161878A1 (en) | 2019-12-17 | 2021-06-24 | Matthew M. Weiss | Irak degraders and uses thereof |
| CN110950839B (zh) * | 2019-12-17 | 2023-04-14 | 蚌埠中实化学技术有限公司 | 4-（4-卤代-1h-吡唑-1-基）哌啶-1-羧酸叔丁酯的制备方法 |
| EP4076524A4 (en) | 2019-12-17 | 2023-11-29 | Kymera Therapeutics, Inc. | IRAQ DEGRADERS AND USES THEREOF |
| EP4161521A4 (en) | 2020-06-03 | 2024-07-10 | Kymera Therapeutics, Inc. | DEUTERED IRAQ DEGRADERS AND USES THEREOF |
| TW202210483A (zh) | 2020-06-03 | 2022-03-16 | 美商凱麥拉醫療公司 | Irak降解劑之結晶型 |
| AR124547A1 (es) | 2020-12-30 | 2023-04-05 | Kymera Therapeutics Inc | Degradadores de irak y sus usos |
| EP4284805A1 (en) | 2021-02-01 | 2023-12-06 | Celgene Corporation | Mk2 inhibitors, the synthesis thereof, and intermediates thereto |
| WO2022174268A1 (en) | 2021-02-15 | 2022-08-18 | Kymera Therapeutics, Inc. | Irak4 degraders and uses thereof |
| CA3217792A1 (en) | 2021-05-07 | 2022-11-10 | Kymera Therapeutics, Inc | Cdk2 degraders and uses thereof |
| JP2024540080A (ja) | 2021-10-29 | 2024-10-31 | カイメラ セラピューティクス， インコーポレイテッド | Ｉｒａｋ４分解剤およびその合成 |
| EP4472967A4 (en) | 2022-01-31 | 2026-04-15 | Kymera Therapeutics Inc | Iraqi Degradation Agents and Their Uses |
| WO2024011116A2 (en) * | 2022-07-07 | 2024-01-11 | Dana-Farber Cancer Institute, Inc. | Potent and selective irreversible inhibitors of irak1 |
| CN115490621B (zh) * | 2022-10-14 | 2024-06-21 | 浙江工业大学 | 一种碘代双环[1.1.1]戊烷衍生物的制备方法 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5559137A (en) * | 1994-05-16 | 1996-09-24 | Smithkline Beecham Corp. | Compounds |
| BR0116493A (pt) * | 2000-12-21 | 2003-09-30 | Vertex Pharma | Compostos de pirazol úteis como inibidores de proteìna cinase |
| US7659270B2 (en) * | 2006-08-11 | 2010-02-09 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
| DE102008025750A1 (de) * | 2008-05-29 | 2009-12-03 | Merck Patent Gmbh | Dihydropyrazolderivate |
| DE102008062825A1 (de) * | 2008-12-23 | 2010-06-24 | Merck Patent Gmbh | 3-(3-Pyrimidin-2-yl-benzyl)-[1,2,4]triazolo [4,3-b]pyridazin-derivate |
| WO2010100144A1 (en) | 2009-03-04 | 2010-09-10 | Merck Serono S.A. | Fused bicyclic compounds as inhibitors for pi3 kinase |
| US20120270237A9 (en) * | 2009-04-03 | 2012-10-25 | Cellzone AG | Methods for the identification of kinase interacting molecules and for the purification of kinase proteins |
| DE102009033208A1 (de) * | 2009-07-15 | 2011-01-20 | Merck Patent Gmbh | Aminopyridinderivate |
| WO2011084402A1 (en) * | 2009-12-21 | 2011-07-14 | Merck Sharp & Dohme Corp. | Tyrosine kinase inhibitors |
| JP5985473B2 (ja) | 2010-07-13 | 2016-09-06 | エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ | ＩＲＡＫ４モジュレーターとしてのピラゾロ［１，５ａ］ピリミジン及びチエノ［３，２ｂ］ピリミジン誘導体 |
-
2013
- 2013-07-03 BR BR112015000399A patent/BR112015000399A2/pt active Search and Examination
- 2013-07-03 SG SG11201500005SA patent/SG11201500005SA/en unknown
- 2013-07-03 CN CN201380047170.9A patent/CN104662014B/zh active Active
- 2013-07-03 ES ES13737134.0T patent/ES2589558T3/es active Active
- 2013-07-03 KR KR20157003049A patent/KR20150033716A/ko not_active Withdrawn
- 2013-07-03 HU HUE13737134A patent/HUE029559T2/en unknown
- 2013-07-03 EP EP13737134.0A patent/EP2872501B1/en active Active
- 2013-07-03 DK DK13737134.0T patent/DK2872501T3/en active
- 2013-07-03 PT PT137371340T patent/PT2872501T/pt unknown
- 2013-07-03 JP JP2015520844A patent/JP6189434B2/ja active Active
- 2013-07-03 AU AU2013289615A patent/AU2013289615B2/en active Active
- 2013-07-03 RU RU2015104123A patent/RU2015104123A/ru not_active Application Discontinuation
- 2013-07-03 CA CA2878621A patent/CA2878621C/en active Active
- 2013-07-03 US US14/406,389 patent/US9216991B2/en active Active
- 2013-07-03 WO PCT/EP2013/001950 patent/WO2014008992A1/en not_active Ceased
- 2013-07-03 MX MX2015000129A patent/MX2015000129A/es unknown
-
2014
- 2014-12-31 IL IL236542A patent/IL236542B/en active IP Right Grant
-
2015
- 2015-02-09 ZA ZA2015/00917A patent/ZA201500917B/en unknown
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2011105738A5 (enExample) | ||
| JP2014235432A5 (enExample) | ||
| JP2013214010A5 (enExample) | ||
| EA201492223A1 (ru) | Новые диазаспироциклоалканы и азаспироциклоалканы | |
| JP2015125255A5 (enExample) | ||
| EA201600091A1 (ru) | 4-членные кольцевые карбоксамиды, применяемые в качестве нематоцидов | |
| JP2014211586A5 (enExample) | ||
| JP2012111758A5 (enExample) | ||
| JP2013212124A5 (enExample) | ||
| JP2012204203A5 (enExample) | ||
| JP2015501646A5 (enExample) | ||
| JP2013532130A5 (enExample) | ||
| JP2015518492A5 (enExample) | ||
| JP2015158628A5 (enExample) | ||
| JP2015173751A5 (enExample) | ||
| WO2015022265A3 (en) | Cyclobutyl carboxamides as nematicides | |
| JP2015537124A5 (enExample) | ||
| JP2013531183A5 (enExample) | ||
| JP2012250569A5 (enExample) | ||
| EA201690294A1 (ru) | Новые соединения и их применение для получения tau-визуализирующих агентов и tau-визуализирующих составов | |
| RU2011118463A (ru) | Ароматические блок-сополиэфиркетоны | |
| JP2014508179A5 (enExample) | ||
| JP2016175963A5 (enExample) | ||
| JP2015030781A5 (enExample) | ||
| RU2013142539A (ru) | Ароматические полиэфиры |