JP2015522045A5 - - Google Patents
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- Publication number
- JP2015522045A5 JP2015522045A5 JP2015520844A JP2015520844A JP2015522045A5 JP 2015522045 A5 JP2015522045 A5 JP 2015522045A5 JP 2015520844 A JP2015520844 A JP 2015520844A JP 2015520844 A JP2015520844 A JP 2015520844A JP 2015522045 A5 JP2015522045 A5 JP 2015522045A5
- Authority
- JP
- Japan
- Prior art keywords
- compounds
- formula
- compound represented
- following groups
- groups
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001875 compounds Chemical class 0.000 claims 2
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261669843P | 2012-07-10 | 2012-07-10 | |
| EP12175660.5 | 2012-07-10 | ||
| EP12175660 | 2012-07-10 | ||
| US61/669,843 | 2012-07-10 | ||
| PCT/EP2013/001950 WO2014008992A1 (en) | 2012-07-10 | 2013-07-03 | Pyrimidine pyrazolyl derivatives |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015522045A JP2015522045A (ja) | 2015-08-03 |
| JP2015522045A5 true JP2015522045A5 (enExample) | 2017-07-06 |
| JP6189434B2 JP6189434B2 (ja) | 2017-08-30 |
Family
ID=49915426
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015520844A Active JP6189434B2 (ja) | 2012-07-10 | 2013-07-03 | ピリミジンピラゾリル誘導体 |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US9216991B2 (enExample) |
| EP (1) | EP2872501B1 (enExample) |
| JP (1) | JP6189434B2 (enExample) |
| KR (1) | KR20150033716A (enExample) |
| CN (1) | CN104662014B (enExample) |
| AU (1) | AU2013289615B2 (enExample) |
| BR (1) | BR112015000399A2 (enExample) |
| CA (1) | CA2878621C (enExample) |
| DK (1) | DK2872501T3 (enExample) |
| ES (1) | ES2589558T3 (enExample) |
| HU (1) | HUE029559T2 (enExample) |
| IL (1) | IL236542B (enExample) |
| MX (1) | MX2015000129A (enExample) |
| PT (1) | PT2872501T (enExample) |
| RU (1) | RU2015104123A (enExample) |
| SG (1) | SG11201500005SA (enExample) |
| WO (1) | WO2014008992A1 (enExample) |
| ZA (1) | ZA201500917B (enExample) |
Families Citing this family (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106068264B (zh) * | 2014-01-09 | 2019-06-21 | 默克专利有限公司 | 嘧啶吡唑基衍生物及其作为irak抑制剂的用途 |
| PL3129023T3 (pl) | 2014-03-27 | 2021-08-16 | Eicosis, Llc | Silne inhibitory rozpuszczalnej hydrolazy epoksydowej |
| PT3221306T (pt) | 2014-11-20 | 2020-02-19 | Merck Patent Gmbh | Compostos de heteroarilo como inibidores de irak e utilização dos mesmos |
| CN105153211B (zh) * | 2015-09-22 | 2017-02-01 | 上海晋鲁医药科技有限公司 | 一种合成1‑(N‑Boc‑4‑哌啶)‑4‑吡唑硼酸频哪醇酯的方法 |
| JP6947743B2 (ja) | 2016-03-03 | 2021-10-13 | バイエル・ファルマ・アクティエンゲゼルシャフト | 新規な２−置換インダゾール、その製造方法、それを含有する医薬製剤、および薬物を製造するためのその使用 |
| JOP20180011A1 (ar) | 2017-02-16 | 2019-01-30 | Gilead Sciences Inc | مشتقات بيرولو [1، 2-b]بيريدازين |
| US10894796B2 (en) | 2017-03-16 | 2021-01-19 | Celgene Car Llc | MK2 inhibitors, synthesis thereof, and intermediates thereto |
| CN106967073A (zh) * | 2017-04-24 | 2017-07-21 | 刘双伟 | 一种治疗类风湿性关节炎的药物 |
| CN106946891B (zh) * | 2017-05-08 | 2018-07-13 | 宿州市徽腾知识产权咨询有限公司 | 一种用于治疗类风湿性关节炎的药物 |
| AU2018338314B2 (en) | 2017-09-22 | 2024-12-12 | Kymera Therapeutics, Inc | Protein degraders and uses thereof |
| WO2019060693A1 (en) | 2017-09-22 | 2019-03-28 | Kymera Therapeutics, Inc. | CRBN LIGANDS AND USES THEREOF |
| WO2019111218A1 (en) | 2017-12-08 | 2019-06-13 | Cadila Healthcare Limited | Novel heterocyclic compounds as irak4 inhibitors |
| IL315310A (en) | 2017-12-26 | 2024-10-01 | Kymera Therapeutics Inc | Irak degraders and uses thereof |
| EP3737675A4 (en) | 2018-01-12 | 2022-01-05 | Kymera Therapeutics, Inc. | Crbn ligands and uses thereof |
| EP3737666A4 (en) | 2018-01-12 | 2022-01-05 | Kymera Therapeutics, Inc. | PROTEIN DEGRADATION AGENTS AND ASSOCIATED USES |
| WO2020010227A1 (en) | 2018-07-06 | 2020-01-09 | Kymera Therapeutics, Inc. | Protein degraders and uses thereof |
| EP3817748A4 (en) | 2018-07-06 | 2022-08-24 | Kymera Therapeutics, Inc. | TRICYCLIC CRBN LIGANDS AND USES THEREOF |
| TWI842978B (zh) | 2018-07-13 | 2024-05-21 | 美商基利科學股份有限公司 | 衍生物 |
| EP3870177A1 (en) * | 2018-10-26 | 2021-09-01 | Arrien Pharmaceuticals LLC | Pyrazolyl compounds and methods of use thereof |
| SG11202105424PA (en) | 2018-11-30 | 2021-06-29 | Kymera Therapeutics Inc | Irak degraders and uses thereof |
| EP4061821B1 (en) * | 2019-11-20 | 2025-08-06 | F. Hoffmann-La Roche AG | Spiro(isobenzofuranazetidine) compounds for the treatment of autoimmune disease |
| WO2021127283A2 (en) | 2019-12-17 | 2021-06-24 | Kymera Therapeutics, Inc. | Irak degraders and uses thereof |
| JP2023509366A (ja) | 2019-12-17 | 2023-03-08 | カイメラ セラピューティクス， インコーポレイテッド | Ｉｒａｋ分解剤およびそれらの使用 |
| CN110950839B (zh) * | 2019-12-17 | 2023-04-14 | 蚌埠中实化学技术有限公司 | 4-（4-卤代-1h-吡唑-1-基）哌啶-1-羧酸叔丁酯的制备方法 |
| TW202210483A (zh) | 2020-06-03 | 2022-03-16 | 美商凱麥拉醫療公司 | Irak降解劑之結晶型 |
| MX2023007852A (es) | 2020-12-30 | 2023-07-07 | Kymera Therapeutics Inc | Degradadores de cinasas asociadas al receptor de interleucina-1 (irak) y usos de los mismos. |
| WO2022165148A1 (en) * | 2021-02-01 | 2022-08-04 | Celgene Corporation | Mk2 inhibitors, the synthesis thereof, and intermediates thereto |
| WO2022174268A1 (en) | 2021-02-15 | 2022-08-18 | Kymera Therapeutics, Inc. | Irak4 degraders and uses thereof |
| AU2022271290A1 (en) | 2021-05-07 | 2023-11-23 | Kymera Therapeutics, Inc. | Cdk2 degraders and uses thereof |
| WO2023076556A1 (en) | 2021-10-29 | 2023-05-04 | Kymera Therapeutics, Inc. | Irak4 degraders and synthesis thereof |
| IL314437A (en) | 2022-01-31 | 2024-09-01 | Kymera Therapeutics Inc | IRAK joints and their uses |
| EP4551218A2 (en) * | 2022-07-07 | 2025-05-14 | Dana-Farber Cancer Institute, Inc. | Potent and selective irreversible inhibitors of irak1 |
| CN115490621B (zh) * | 2022-10-14 | 2024-06-21 | 浙江工业大学 | 一种碘代双环[1.1.1]戊烷衍生物的制备方法 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5559137A (en) * | 1994-05-16 | 1996-09-24 | Smithkline Beecham Corp. | Compounds |
| CA2432131C (en) * | 2000-12-21 | 2008-07-08 | Vertex Pharmaceuticals Incorporated | Pyrazole compounds useful as protein kinase inhibitors |
| US7659270B2 (en) * | 2006-08-11 | 2010-02-09 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
| DE102008025750A1 (de) * | 2008-05-29 | 2009-12-03 | Merck Patent Gmbh | Dihydropyrazolderivate |
| DE102008062825A1 (de) * | 2008-12-23 | 2010-06-24 | Merck Patent Gmbh | 3-(3-Pyrimidin-2-yl-benzyl)-[1,2,4]triazolo [4,3-b]pyridazin-derivate |
| WO2010100144A1 (en) | 2009-03-04 | 2010-09-10 | Merck Serono S.A. | Fused bicyclic compounds as inhibitors for pi3 kinase |
| EP2414337B1 (en) * | 2009-04-03 | 2013-05-01 | Cellzome GmbH | Methods for the identification of kinase interacting molecules and for the purification of kinase proteins |
| DE102009033208A1 (de) * | 2009-07-15 | 2011-01-20 | Merck Patent Gmbh | Aminopyridinderivate |
| JP2013514973A (ja) * | 2009-12-21 | 2013-05-02 | メルク・シャープ・エンド・ドーム・コーポレイション | チロシンキナーゼ阻害剤 |
| KR101995013B1 (ko) * | 2010-07-13 | 2019-07-02 | 에프. 호프만-라 로슈 아게 | Irak4 조절제로서 피라졸로[1,5a]피리미딘 및 티에노[3,2b]피리미딘 유도체 |
-
2013
- 2013-07-03 KR KR20157003049A patent/KR20150033716A/ko not_active Withdrawn
- 2013-07-03 CN CN201380047170.9A patent/CN104662014B/zh active Active
- 2013-07-03 WO PCT/EP2013/001950 patent/WO2014008992A1/en not_active Ceased
- 2013-07-03 HU HUE13737134A patent/HUE029559T2/en unknown
- 2013-07-03 BR BR112015000399A patent/BR112015000399A2/pt active Search and Examination
- 2013-07-03 CA CA2878621A patent/CA2878621C/en active Active
- 2013-07-03 MX MX2015000129A patent/MX2015000129A/es unknown
- 2013-07-03 AU AU2013289615A patent/AU2013289615B2/en active Active
- 2013-07-03 DK DK13737134.0T patent/DK2872501T3/en active
- 2013-07-03 US US14/406,389 patent/US9216991B2/en active Active
- 2013-07-03 RU RU2015104123A patent/RU2015104123A/ru not_active Application Discontinuation
- 2013-07-03 JP JP2015520844A patent/JP6189434B2/ja active Active
- 2013-07-03 EP EP13737134.0A patent/EP2872501B1/en active Active
- 2013-07-03 PT PT137371340T patent/PT2872501T/pt unknown
- 2013-07-03 SG SG11201500005SA patent/SG11201500005SA/en unknown
- 2013-07-03 ES ES13737134.0T patent/ES2589558T3/es active Active
-
2014
- 2014-12-31 IL IL236542A patent/IL236542B/en active IP Right Grant
-
2015
- 2015-02-09 ZA ZA2015/00917A patent/ZA201500917B/en unknown
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