JP2015522045A5 - - Google Patents
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- Publication number
- JP2015522045A5 JP2015522045A5 JP2015520844A JP2015520844A JP2015522045A5 JP 2015522045 A5 JP2015522045 A5 JP 2015522045A5 JP 2015520844 A JP2015520844 A JP 2015520844A JP 2015520844 A JP2015520844 A JP 2015520844A JP 2015522045 A5 JP2015522045 A5 JP 2015522045A5
- Authority
- JP
- Japan
- Prior art keywords
- compounds
- formula
- compound represented
- following groups
- groups
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001875 compounds Chemical class 0.000 claims 2
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261669843P | 2012-07-10 | 2012-07-10 | |
| US61/669,843 | 2012-07-10 | ||
| EP12175660.5 | 2012-07-10 | ||
| EP12175660 | 2012-07-10 | ||
| PCT/EP2013/001950 WO2014008992A1 (en) | 2012-07-10 | 2013-07-03 | Pyrimidine pyrazolyl derivatives |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015522045A JP2015522045A (ja) | 2015-08-03 |
| JP2015522045A5 true JP2015522045A5 (enExample) | 2017-07-06 |
| JP6189434B2 JP6189434B2 (ja) | 2017-08-30 |
Family
ID=49915426
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015520844A Active JP6189434B2 (ja) | 2012-07-10 | 2013-07-03 | ピリミジンピラゾリル誘導体 |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US9216991B2 (enExample) |
| EP (1) | EP2872501B1 (enExample) |
| JP (1) | JP6189434B2 (enExample) |
| KR (1) | KR20150033716A (enExample) |
| CN (1) | CN104662014B (enExample) |
| AU (1) | AU2013289615B2 (enExample) |
| BR (1) | BR112015000399A2 (enExample) |
| CA (1) | CA2878621C (enExample) |
| DK (1) | DK2872501T3 (enExample) |
| ES (1) | ES2589558T3 (enExample) |
| HU (1) | HUE029559T2 (enExample) |
| IL (1) | IL236542B (enExample) |
| MX (1) | MX2015000129A (enExample) |
| PT (1) | PT2872501T (enExample) |
| RU (1) | RU2015104123A (enExample) |
| SG (1) | SG11201500005SA (enExample) |
| WO (1) | WO2014008992A1 (enExample) |
| ZA (1) | ZA201500917B (enExample) |
Families Citing this family (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2728403T3 (es) * | 2014-01-09 | 2019-10-24 | Merck Patent Gmbh | Derivados de pirimidin pirazolilo y su uso como inhibidores de IRAK |
| ES2871027T3 (es) | 2014-03-27 | 2021-10-28 | Eicosis Llc | Inhibidores potentes de la epóxido hidrolasa soluble |
| NZ730728A (en) * | 2014-11-20 | 2022-04-29 | Merck Patent Gmbh | Heteroaryl compounds as irak inhibitors and uses thereof |
| CN105153211B (zh) * | 2015-09-22 | 2017-02-01 | 上海晋鲁医药科技有限公司 | 一种合成1‑(N‑Boc‑4‑哌啶)‑4‑吡唑硼酸频哪醇酯的方法 |
| US10435396B2 (en) | 2016-03-03 | 2019-10-08 | Bayer Pharma Aktiegesellschaft | 2-substituted indazoles, methods for producing same, pharmaceutical preparations that contain same, and use of same to produce drugs |
| JOP20180011A1 (ar) | 2017-02-16 | 2019-01-30 | Gilead Sciences Inc | مشتقات بيرولو [1، 2-b]بيريدازين |
| MX387359B (es) | 2017-03-16 | 2025-03-18 | Bristol Myers Squibb Co | Inhibidores de cinasa activada por mitógeno 2 (mk2), síntesis de los mismos, e intermediarios de los mismos. |
| CN106967073A (zh) * | 2017-04-24 | 2017-07-21 | 刘双伟 | 一种治疗类风湿性关节炎的药物 |
| CN106946891B (zh) * | 2017-05-08 | 2018-07-13 | 宿州市徽腾知识产权咨询有限公司 | 一种用于治疗类风湿性关节炎的药物 |
| WO2019060742A1 (en) | 2017-09-22 | 2019-03-28 | Kymera Therapeutics, Inc | AGENTS FOR DEGRADING PROTEINS AND USES THEREOF |
| US11358948B2 (en) | 2017-09-22 | 2022-06-14 | Kymera Therapeutics, Inc. | CRBN ligands and uses thereof |
| WO2019111218A1 (en) | 2017-12-08 | 2019-06-13 | Cadila Healthcare Limited | Novel heterocyclic compounds as irak4 inhibitors |
| IL315310A (en) | 2017-12-26 | 2024-10-01 | Kymera Therapeutics Inc | Irak degraders and uses thereof |
| WO2019140387A1 (en) | 2018-01-12 | 2019-07-18 | Kymera Therapeutics, Inc. | Crbn ligands and uses thereof |
| US11485743B2 (en) | 2018-01-12 | 2022-11-01 | Kymera Therapeutics, Inc. | Protein degraders and uses thereof |
| WO2020010227A1 (en) | 2018-07-06 | 2020-01-09 | Kymera Therapeutics, Inc. | Protein degraders and uses thereof |
| WO2020010177A1 (en) | 2018-07-06 | 2020-01-09 | Kymera Therapeutics, Inc. | Tricyclic crbn ligands and uses thereof |
| TWI721483B (zh) | 2018-07-13 | 2021-03-11 | 美商基利科學股份有限公司 | 吡咯并[1,2-b]嗒𠯤衍生物 |
| JP7186874B2 (ja) * | 2018-10-26 | 2022-12-09 | アーリーン ファーマシューティカルズ エルエルシー | ピラゾリル化合物およびその使用方法 |
| CA3119773A1 (en) | 2018-11-30 | 2020-06-04 | Kymera Therapeutics, Inc. | Irak degraders and uses thereof |
| MX2021015995A (es) | 2019-06-28 | 2022-03-11 | Kymera Therapeutics Inc | Degradadores de cinasas asociadas al receptor de interleucina-1 (irak) y usos de los mismos. |
| US12558427B2 (en) | 2019-07-17 | 2026-02-24 | Kymera Therapeutics, Inc. | IRAK degraders and uses thereof |
| WO2021099406A1 (en) * | 2019-11-20 | 2021-05-27 | F. Hoffmann-La Roche Ag | Spiro(isobenzofuranazetidine) compounds for the treatment of autoimmune disease |
| US12551564B2 (en) | 2019-12-10 | 2026-02-17 | Kymera Therapeutics, Inc. | IRAK degraders and uses thereof |
| US11591332B2 (en) | 2019-12-17 | 2023-02-28 | Kymera Therapeutics, Inc. | IRAK degraders and uses thereof |
| CN110950839B (zh) * | 2019-12-17 | 2023-04-14 | 蚌埠中实化学技术有限公司 | 4-（4-卤代-1h-吡唑-1-基）哌啶-1-羧酸叔丁酯的制备方法 |
| CN115052627A (zh) | 2019-12-17 | 2022-09-13 | 凯麦拉医疗公司 | Irak降解剂和其用途 |
| TW202210483A (zh) | 2020-06-03 | 2022-03-16 | 美商凱麥拉醫療公司 | Irak降解劑之結晶型 |
| CA3202360A1 (en) | 2020-12-30 | 2022-07-07 | Nello Mainolfi | Irak degraders and uses thereof |
| AR124726A1 (es) * | 2021-02-01 | 2023-04-26 | Celgene Corp | Inhibidores de nk2, su síntesis y sus intermedios |
| CA3207049A1 (en) | 2021-02-15 | 2022-08-18 | Jared Gollob | Irak4 degraders and uses thereof |
| KR20240020735A (ko) | 2021-05-07 | 2024-02-15 | 카이메라 쎄라퓨틱스 인코포레이티드 | Cdk2 분해제 및 그 용도 |
| CA3236265A1 (en) | 2021-10-29 | 2023-05-04 | William Leong | Irak4 degraders and synthesis thereof |
| US12091411B2 (en) | 2022-01-31 | 2024-09-17 | Kymera Therapeutics, Inc. | IRAK degraders and uses thereof |
| EP4551218A2 (en) * | 2022-07-07 | 2025-05-14 | Dana-Farber Cancer Institute, Inc. | Potent and selective irreversible inhibitors of irak1 |
| CN115490621B (zh) * | 2022-10-14 | 2024-06-21 | 浙江工业大学 | 一种碘代双环[1.1.1]戊烷衍生物的制备方法 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5559137A (en) * | 1994-05-16 | 1996-09-24 | Smithkline Beecham Corp. | Compounds |
| HUP0400639A3 (en) * | 2000-12-21 | 2010-03-29 | Vertex Pharma | Pyrazole compounds useful as protein kinase inhibitors and pharmaceutical compositions containing them |
| US7659270B2 (en) * | 2006-08-11 | 2010-02-09 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
| DE102008025750A1 (de) * | 2008-05-29 | 2009-12-03 | Merck Patent Gmbh | Dihydropyrazolderivate |
| DE102008062825A1 (de) * | 2008-12-23 | 2010-06-24 | Merck Patent Gmbh | 3-(3-Pyrimidin-2-yl-benzyl)-[1,2,4]triazolo [4,3-b]pyridazin-derivate |
| WO2010100144A1 (en) | 2009-03-04 | 2010-09-10 | Merck Serono S.A. | Fused bicyclic compounds as inhibitors for pi3 kinase |
| WO2010112210A1 (en) | 2009-04-03 | 2010-10-07 | Cellzome Ag | Methods for the identification of kinase interacting molecules and for the purification of kinase proteins |
| DE102009033208A1 (de) * | 2009-07-15 | 2011-01-20 | Merck Patent Gmbh | Aminopyridinderivate |
| CA2782885A1 (en) * | 2009-12-21 | 2011-07-14 | Merck Sharp & Dohme Corp. | Tyrosine kinase inhibitors |
| KR101995013B1 (ko) * | 2010-07-13 | 2019-07-02 | 에프. 호프만-라 로슈 아게 | Irak4 조절제로서 피라졸로[1,5a]피리미딘 및 티에노[3,2b]피리미딘 유도체 |
-
2013
- 2013-07-03 CN CN201380047170.9A patent/CN104662014B/zh active Active
- 2013-07-03 EP EP13737134.0A patent/EP2872501B1/en active Active
- 2013-07-03 HU HUE13737134A patent/HUE029559T2/en unknown
- 2013-07-03 MX MX2015000129A patent/MX2015000129A/es unknown
- 2013-07-03 JP JP2015520844A patent/JP6189434B2/ja active Active
- 2013-07-03 AU AU2013289615A patent/AU2013289615B2/en active Active
- 2013-07-03 ES ES13737134.0T patent/ES2589558T3/es active Active
- 2013-07-03 RU RU2015104123A patent/RU2015104123A/ru not_active Application Discontinuation
- 2013-07-03 DK DK13737134.0T patent/DK2872501T3/en active
- 2013-07-03 PT PT137371340T patent/PT2872501T/pt unknown
- 2013-07-03 SG SG11201500005SA patent/SG11201500005SA/en unknown
- 2013-07-03 US US14/406,389 patent/US9216991B2/en active Active
- 2013-07-03 KR KR20157003049A patent/KR20150033716A/ko not_active Withdrawn
- 2013-07-03 BR BR112015000399A patent/BR112015000399A2/pt active Search and Examination
- 2013-07-03 CA CA2878621A patent/CA2878621C/en active Active
- 2013-07-03 WO PCT/EP2013/001950 patent/WO2014008992A1/en not_active Ceased
-
2014
- 2014-12-31 IL IL236542A patent/IL236542B/en active IP Right Grant
-
2015
- 2015-02-09 ZA ZA2015/00917A patent/ZA201500917B/en unknown
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