|
US4217344A
(en)
|
1976-06-23 |
1980-08-12 |
L'oreal |
Compositions containing aqueous dispersions of lipid spheres
|
|
US4235871A
(en)
|
1978-02-24 |
1980-11-25 |
Papahadjopoulos Demetrios P |
Method of encapsulating biologically active materials in lipid vesicles
|
|
US4186183A
(en)
|
1978-03-29 |
1980-01-29 |
The United States Of America As Represented By The Secretary Of The Army |
Liposome carriers in chemotherapy of leishmaniasis
|
|
US4182449A
(en)
|
1978-04-18 |
1980-01-08 |
Kozlow William J |
Adhesive bandage and package
|
|
US4261975A
(en)
|
1979-09-19 |
1981-04-14 |
Merck & Co., Inc. |
Viral liposome particle
|
|
US4663290A
(en)
|
1982-01-21 |
1987-05-05 |
Molecular Genetics, Inc. |
Production of reverse transcriptase
|
|
US4485054A
(en)
|
1982-10-04 |
1984-11-27 |
Lipoderm Pharmaceuticals Limited |
Method of encapsulating biologically active materials in multilamellar lipid vesicles (MLV)
|
|
US4501728A
(en)
|
1983-01-06 |
1985-02-26 |
Technology Unlimited, Inc. |
Masking of liposomes from RES recognition
|
|
US4880635B1
(en)
|
1984-08-08 |
1996-07-02 |
Liposome Company |
Dehydrated liposomes
|
|
US5049386A
(en)
|
1985-01-07 |
1991-09-17 |
Syntex (U.S.A.) Inc. |
N-ω,(ω-1)-dialkyloxy)- and N-(ω,(ω-1)-dialkenyloxy)Alk-1-YL-N,N,N-tetrasubstituted ammonium lipids and uses therefor
|
|
US4946787A
(en)
|
1985-01-07 |
1990-08-07 |
Syntex (U.S.A.) Inc. |
N-(ω,(ω-1)-dialkyloxy)- and N-(ω,(ω-1)-dialkenyloxy)-alk-1-yl-N,N,N-tetrasubstituted ammonium lipids and uses therefor
|
|
US4897355A
(en)
|
1985-01-07 |
1990-01-30 |
Syntex (U.S.A.) Inc. |
N[ω,(ω-1)-dialkyloxy]- and N-[ω,(ω-1)-dialkenyloxy]-alk-1-yl-N,N,N-tetrasubstituted ammonium lipids and uses therefor
|
|
US4797368A
(en)
|
1985-03-15 |
1989-01-10 |
The United States Of America As Represented By The Department Of Health And Human Services |
Adeno-associated virus as eukaryotic expression vector
|
|
US4921757A
(en)
|
1985-04-26 |
1990-05-01 |
Massachusetts Institute Of Technology |
System for delayed and pulsed release of biologically active substances
|
|
US4774085A
(en)
|
1985-07-09 |
1988-09-27 |
501 Board of Regents, Univ. of Texas |
Pharmaceutical administration systems containing a mixture of immunomodulators
|
|
US5139941A
(en)
|
1985-10-31 |
1992-08-18 |
University Of Florida Research Foundation, Inc. |
AAV transduction vectors
|
|
US4737323A
(en)
|
1986-02-13 |
1988-04-12 |
Liposome Technology, Inc. |
Liposome extrusion method
|
|
US5017492A
(en)
|
1986-02-27 |
1991-05-21 |
Life Technologies, Inc. |
Reverse transcriptase and method for its production
|
|
DE122007000007I1
(de)
|
1986-04-09 |
2007-05-16 |
Genzyme Corp |
Genetisch transformierte Tiere, die ein gewünschtes Protein in Milch absondern
|
|
US4889818A
(en)
|
1986-08-22 |
1989-12-26 |
Cetus Corporation |
Purified thermostable enzyme
|
|
US5079352A
(en)
|
1986-08-22 |
1992-01-07 |
Cetus Corporation |
Purified thermostable enzyme
|
|
US5374553A
(en)
|
1986-08-22 |
1994-12-20 |
Hoffmann-La Roche Inc. |
DNA encoding a thermostable nucleic acid polymerase enzyme from thermotoga maritima
|
|
US4837028A
(en)
|
1986-12-24 |
1989-06-06 |
Liposome Technology, Inc. |
Liposomes with enhanced circulation time
|
|
US4920016A
(en)
|
1986-12-24 |
1990-04-24 |
Linear Technology, Inc. |
Liposomes with enhanced circulation time
|
|
JPH0825869B2
(ja)
|
1987-02-09 |
1996-03-13 |
株式会社ビタミン研究所 |
抗腫瘍剤包埋リポソ−ム製剤
|
|
US4911928A
(en)
|
1987-03-13 |
1990-03-27 |
Micro-Pak, Inc. |
Paucilamellar lipid vesicles
|
|
US4917951A
(en)
|
1987-07-28 |
1990-04-17 |
Micro-Pak, Inc. |
Lipid vesicles formed of surfactants and steroids
|
|
JPH068256B2
(ja)
|
1987-04-23 |
1994-02-02 |
エフ エム シー コーポレーション |
殺虫性シクロプロピル置換ジ(アリール)化合物類
|
|
US4873316A
(en)
|
1987-06-23 |
1989-10-10 |
Biogen, Inc. |
Isolation of exogenous recombinant proteins from the milk of transgenic mammals
|
|
RO114469B1
(ro)
|
1987-12-15 |
1999-04-30 |
Gene Shears Pty Ltd |
Compus oligoribonucleotidic, procedeu de preparare si metoda de inactivare
|
|
US5244797B1
(en)
|
1988-01-13 |
1998-08-25 |
Life Technologies Inc |
Cloned genes encoding reverse transcriptase lacking rnase h activity
|
|
US4965185A
(en)
|
1988-06-22 |
1990-10-23 |
Grischenko Valentin I |
Method for low-temperature preservation of embryos
|
|
US5223409A
(en)
|
1988-09-02 |
1993-06-29 |
Protein Engineering Corp. |
Directed evolution of novel binding proteins
|
|
AU4308689A
(en)
|
1988-09-02 |
1990-04-02 |
Protein Engineering Corporation |
Generation and selection of recombinant varied binding proteins
|
|
US5047342A
(en)
|
1989-08-10 |
1991-09-10 |
Life Technologies, Inc. |
Cloning and expression of T5 DNA polymerase
|
|
US5270179A
(en)
|
1989-08-10 |
1993-12-14 |
Life Technologies, Inc. |
Cloning and expression of T5 DNA polymerase reduced in 3'- to-5' exonuclease activity
|
|
AU637800B2
(en)
|
1989-08-31 |
1993-06-10 |
City Of Hope |
Chimeric dna-rna catalytic sequences
|
|
US5264618A
(en)
|
1990-04-19 |
1993-11-23 |
Vical, Inc. |
Cationic lipids for intracellular delivery of biologically active molecules
|
|
US5427908A
(en)
|
1990-05-01 |
1995-06-27 |
Affymax Technologies N.V. |
Recombinant library screening methods
|
|
AU7979491A
(en)
|
1990-05-03 |
1991-11-27 |
Vical, Inc. |
Intracellular delivery of biologically active substances by means of self-assembling lipid complexes
|
|
US5637459A
(en)
|
1990-06-11 |
1997-06-10 |
Nexstar Pharmaceuticals, Inc. |
Systematic evolution of ligands by exponential enrichment: chimeric selex
|
|
US5580737A
(en)
|
1990-06-11 |
1996-12-03 |
Nexstar Pharmaceuticals, Inc. |
High-affinity nucleic acid ligands that discriminate between theophylline and caffeine
|
|
AU663474B2
(en)
|
1990-09-28 |
1995-10-12 |
F. Hoffmann-La Roche Ag |
5' to 3' exonuclease mutations of thermostable DNA polymerases
|
|
DE553264T1
(de)
|
1990-10-05 |
1994-04-28 |
Wayne M Barnes |
Thermostabile dna polymerase.
|
|
US5672695A
(en)
|
1990-10-12 |
1997-09-30 |
Max-Planck-Gesellschaft Zur Forderung Der Wissenschaften E.V. |
Modified ribozymes
|
|
US5173414A
(en)
|
1990-10-30 |
1992-12-22 |
Applied Immune Sciences, Inc. |
Production of recombinant adeno-associated virus vectors
|
|
NZ241310A
(en)
|
1991-01-17 |
1995-03-28 |
Gen Hospital Corp |
Trans-splicing ribozymes
|
|
NZ314630A
(en)
|
1991-01-17 |
2000-11-24 |
Harvard College |
Use of trans-splicing ribozymes for genetic modification and cell ablation in a host cell
|
|
ES2223040T3
(es)
|
1991-04-10 |
2005-02-16 |
The Scripps Research Institute |
Bibliotecas de receptor heterodimerilo que usan fagemidos.
|
|
DE4216134A1
(de)
|
1991-06-20 |
1992-12-24 |
Europ Lab Molekularbiolog |
Synthetische katalytische oligonukleotidstrukturen
|
|
US6872816B1
(en)
|
1996-01-24 |
2005-03-29 |
Third Wave Technologies, Inc. |
Nucleic acid detection kits
|
|
US5652094A
(en)
|
1992-01-31 |
1997-07-29 |
University Of Montreal |
Nucleozymes
|
|
JPH05274181A
(ja)
|
1992-03-25 |
1993-10-22 |
Nec Corp |
ブレークポイント設定・解除方式
|
|
US5587308A
(en)
|
1992-06-02 |
1996-12-24 |
The United States Of America As Represented By The Department Of Health & Human Services |
Modified adeno-associated virus vector capable of expression from a novel promoter
|
|
US5834247A
(en)
|
1992-12-09 |
1998-11-10 |
New England Biolabs, Inc. |
Modified proteins comprising controllable intervening protein sequences or their elements methods of producing same and methods for purification of a target protein comprised by a modified protein
|
|
US5496714A
(en)
|
1992-12-09 |
1996-03-05 |
New England Biolabs, Inc. |
Modification of protein by use of a controllable interveining protein sequence
|
|
US5434058A
(en)
|
1993-02-09 |
1995-07-18 |
Arch Development Corporation |
Apolipoprotein B MRNA editing protein compositions and methods
|
|
US5436149A
(en)
|
1993-02-19 |
1995-07-25 |
Barnes; Wayne M. |
Thermostable DNA polymerase with enhanced thermostability and enhanced length and efficiency of primer extension
|
|
CN1127527A
(zh)
|
1993-05-17 |
1996-07-24 |
加利福尼亚大学董事会 |
人免疫缺陷型病毒感染和艾滋病的核酶基因治疗方法
|
|
US5512462A
(en)
|
1994-02-25 |
1996-04-30 |
Hoffmann-La Roche Inc. |
Methods and reagents for the polymerase chain reaction amplification of long DNA sequences
|
|
US5651981A
(en)
|
1994-03-29 |
1997-07-29 |
Northwestern University |
Cationic phospholipids for transfection
|
|
US5874560A
(en)
|
1994-04-22 |
1999-02-23 |
The United States Of America As Represented By The Department Of Health And Human Services |
Melanoma antigens and their use in diagnostic and therapeutic methods
|
|
WO1995031183A1
(en)
|
1994-05-16 |
1995-11-23 |
Washington University |
Cell membrane fusion composition and method
|
|
US5912155A
(en)
|
1994-09-30 |
1999-06-15 |
Life Technologies, Inc. |
Cloned DNA polymerases from Thermotoga neapolitana
|
|
US5614365A
(en)
|
1994-10-17 |
1997-03-25 |
President & Fellow Of Harvard College |
DNA polymerase having modified nucleotide binding site for DNA sequencing
|
|
US5449639A
(en)
|
1994-10-24 |
1995-09-12 |
Taiwan Semiconductor Manufacturing Company Ltd. |
Disposable metal anti-reflection coating process used together with metal dry/wet etch
|
|
US5767099A
(en)
|
1994-12-09 |
1998-06-16 |
Genzyme Corporation |
Cationic amphiphiles containing amino acid or dervatized amino acid groups for intracellular delivery of therapeutic molecules
|
|
US6057153A
(en)
|
1995-01-13 |
2000-05-02 |
Yale University |
Stabilized external guide sequences
|
|
US5795587A
(en)
|
1995-01-23 |
1998-08-18 |
University Of Pittsburgh |
Stable lipid-comprising drug delivery complexes and methods for their production
|
|
US5830430A
(en)
|
1995-02-21 |
1998-11-03 |
Imarx Pharmaceutical Corp. |
Cationic lipids and the use thereof
|
|
US5851548A
(en)
|
1995-06-07 |
1998-12-22 |
Gen-Probe Incorporated |
Liposomes containing cationic lipids and vitamin D
|
|
US5773258A
(en)
|
1995-08-25 |
1998-06-30 |
Roche Molecular Systems, Inc. |
Nucleic acid amplification using a reversibly inactivated thermostable enzyme
|
|
NO953680D0
(no)
|
1995-09-18 |
1995-09-18 |
Hans Prydz |
Cellesyklusenzymer
|
|
GB9600384D0
(en)
|
1996-01-09 |
1996-03-13 |
Nyfotek As |
Dna glycosylases
|
|
US5962313A
(en)
|
1996-01-18 |
1999-10-05 |
Avigen, Inc. |
Adeno-associated virus vectors comprising a gene encoding a lyosomal enzyme
|
|
US5840839A
(en)
|
1996-02-09 |
1998-11-24 |
The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services |
Alternative open reading frame DNA of a normal gene and a novel human cancer antigen encoded therein
|
|
WO1997044348A1
(en)
|
1996-05-17 |
1997-11-27 |
Thomas Jefferson University |
Ribozyme-mediated gene replacement
|
|
US20040156861A1
(en)
|
1996-07-11 |
2004-08-12 |
Figdor Carl Gustav |
Melanoma associated peptide analogues and vaccines against melanoma
|
|
US6887707B2
(en)
|
1996-10-28 |
2005-05-03 |
University Of Washington |
Induction of viral mutation by incorporation of miscoding ribonucleoside analogs into viral RNA
|
|
GB9701425D0
(en)
|
1997-01-24 |
1997-03-12 |
Bioinvent Int Ab |
A method for in vitro molecular evolution of protein function
|
|
AU735459B2
(en)
|
1997-01-30 |
2001-07-12 |
University Of Virginia Patent Foundation |
Cysteine-depleted peptides recognized by A3-restricted cytotoxic lymphocytes, and uses therefor
|
|
US5981182A
(en)
|
1997-03-13 |
1999-11-09 |
Albert Einstein College Of Medicine Of Yeshiva University |
Vector constructs for the selection and identification of open reading frames
|
|
AU7567298A
(en)
|
1997-05-09 |
1998-11-27 |
Fred Hutchinson Cancer Research Center |
(mus dunni) endogenous retroviral packaging cell lines
|
|
US20040203109A1
(en)
|
1997-06-06 |
2004-10-14 |
Incyte Corporation |
Human regulatory proteins
|
|
US5849528A
(en)
|
1997-08-21 |
1998-12-15 |
Incyte Pharmaceuticals, Inc.. |
Polynucleotides encoding a human S100 protein
|
|
AU9399498A
(en)
|
1997-09-18 |
1999-04-05 |
Trustees Of The University Of Pennsylvania, The |
Receptor-binding pocket mutants of influenza a virus hemagglutinin for use in targeted gene delivery
|
|
US6355415B1
(en)
|
1997-09-29 |
2002-03-12 |
Ohio University |
Compositions and methods for the use of ribozymes to determine gene function
|
|
US6156509A
(en)
|
1997-11-12 |
2000-12-05 |
Genencor International, Inc. |
Method of increasing efficiency of directed evolution of a gene using phagemid
|
|
US6429301B1
(en)
|
1998-04-17 |
2002-08-06 |
Whitehead Institute For Biomedical Research |
Use of a ribozyme to join nucleic acids and peptides
|
|
US6183998B1
(en)
|
1998-05-29 |
2001-02-06 |
Qiagen Gmbh Max-Volmer-Strasse 4 |
Method for reversible modification of thermostable enzymes
|
|
EP1085892A4
(en)
|
1998-06-12 |
2002-07-17 |
Sloan Kettering Inst Cancer |
VACCINATION STRATEGY FOR PREVENTING AND TREATING CANCERS
|
|
US8097648B2
(en)
|
1998-06-17 |
2012-01-17 |
Eisai R&D Management Co., Ltd. |
Methods and compositions for use in treating cancer
|
|
EP2386646B1
(en)
|
1998-10-01 |
2016-12-21 |
University Of Southern California |
Gene delivery system and methods of use
|
|
AU1115300A
(en)
|
1998-10-13 |
2000-05-01 |
Advanced Research And Technology Institute, Inc. |
Assays for identifying functional alterations in the p53 tumor suppressor
|
|
NZ512244A
(en)
|
1998-11-12 |
2003-12-19 |
Invitrogen Corp |
Polycationic transfection reagents for introducing anions into a cell
|
|
US6534261B1
(en)
|
1999-01-12 |
2003-03-18 |
Sangamo Biosciences, Inc. |
Regulation of endogenous gene expression in cells using zinc finger proteins
|
|
US6453242B1
(en)
|
1999-01-12 |
2002-09-17 |
Sangamo Biosciences, Inc. |
Selection of sites for targeting by zinc finger proteins and methods of designing zinc finger proteins to bind to preselected sites
|
|
US7013219B2
(en)
|
1999-01-12 |
2006-03-14 |
Sangamo Biosciences, Inc. |
Regulation of endogenous gene expression in cells using zinc finger proteins
|
|
US6599692B1
(en)
|
1999-09-14 |
2003-07-29 |
Sangamo Bioscience, Inc. |
Functional genomics using zinc finger proteins
|
|
US20090130718A1
(en)
|
1999-02-04 |
2009-05-21 |
Diversa Corporation |
Gene site saturation mutagenesis
|
|
EP1174509A4
(en)
|
1999-03-29 |
2003-10-22 |
Kansai Tech Licensing Org Co |
cytidine deaminase
|
|
US6365410B1
(en)
|
1999-05-19 |
2002-04-02 |
Genencor International, Inc. |
Directed evolution of microorganisms
|
|
GB9920194D0
(en)
|
1999-08-27 |
1999-10-27 |
Advanced Biotech Ltd |
A heat-stable thermostable DNA polymerase for use in nucleic acid amplification
|
|
CN101363029B
(zh)
|
1999-10-12 |
2016-01-13 |
巴斯德研究所 |
慢病毒三链体dna、及含有慢病毒三链体dna的载体和重组细胞
|
|
EP1230268B1
(en)
|
1999-11-18 |
2009-10-14 |
Pharmexa Inc. |
Heteroclitic analogs of class i epitopes
|
|
AU785007B2
(en)
|
1999-11-24 |
2006-08-24 |
Mcs Micro Carrier Systems Gmbh |
Polypeptides comprising multimers of nuclear localization signals or of protein transduction domains and their use for transferring molecules into cells
|
|
CA2394850C
(en)
|
1999-12-06 |
2012-02-07 |
Sangamo Biosciences, Inc. |
Methods of using randomized libraries of zinc finger proteins for the identification of gene function
|
|
EP2207032A1
(en)
|
2000-02-08 |
2010-07-14 |
Sangamo BioSciences, Inc. |
Cells expressing zinc finger protein for drug discovery
|
|
US7378248B2
(en)
|
2000-03-06 |
2008-05-27 |
Rigel Pharmaceuticals, Inc. |
In vivo production of cyclic peptides for inhibiting protein-protein interaction
|
|
US7078208B2
(en)
|
2000-05-26 |
2006-07-18 |
Invitrogen Corporation |
Thermostable reverse transcriptases and uses thereof
|
|
JP4700888B2
(ja)
|
2000-06-01 |
2011-06-15 |
株式会社ディナベック研究所 |
ヘマグルチニン活性を有する膜蛋白質を含むシュードタイプレトロウイルスベクター
|
|
CN1196788C
(zh)
|
2000-06-23 |
2005-04-13 |
惠氏控股有限公司 |
野生型和嵌合流感病毒样颗粒(vlp)的装配
|
|
US6573092B1
(en)
|
2000-10-10 |
2003-06-03 |
Genvec, Inc. |
Method of preparing a eukaryotic viral vector
|
|
EP1201750A1
(en)
|
2000-10-26 |
2002-05-02 |
Genopoietic |
Synthetic viruses and uses thereof
|
|
ES2330083T3
(es)
|
2000-10-27 |
2009-12-04 |
Novartis Vaccines And Diagnostics S.R.L. |
Acidos nucleicos y proteinas de estreptococos de los grupos a y b.
|
|
US20040003420A1
(en)
|
2000-11-10 |
2004-01-01 |
Ralf Kuhn |
Modified recombinase
|
|
US7067650B1
(en)
|
2000-11-22 |
2006-06-27 |
National Institute Of Advanced Industrial Science And Technology |
Ribozymes targeting bradeion transcripts and use thereof
|
|
NZ527208A
(en)
|
2001-01-25 |
2005-05-27 |
Evolva Ltd |
Concatemers of differentially expressed multiple genes
|
|
US20050222030A1
(en)
|
2001-02-21 |
2005-10-06 |
Anthony Allison |
Modified annexin proteins and methods for preventing thrombosis
|
|
US20040115184A1
(en)
|
2001-02-27 |
2004-06-17 |
Smith Harold C |
Methods and compositions for modifying apolipoprotein b mrna editing
|
|
US7807408B2
(en)
|
2001-03-19 |
2010-10-05 |
President & Fellows Of Harvard College |
Directed evolution of proteins
|
|
DE60213826T3
(de)
|
2001-03-19 |
2013-10-17 |
President And Fellows Of Harvard College |
Entwicklung neuer molekularer funktionen
|
|
US7476500B1
(en)
|
2001-03-19 |
2009-01-13 |
President And Fellows Of Harvard College |
In vivo selection system for enzyme activity
|
|
WO2002074978A2
(en)
|
2001-03-19 |
2002-09-26 |
President And Fellows Of Harvard College |
Nucleic acid shuffling
|
|
US20040197892A1
(en)
|
2001-04-04 |
2004-10-07 |
Michael Moore |
Composition binding polypeptides
|
|
MXPA03009566A
(es)
|
2001-04-19 |
2004-12-06 |
Scripps Research Inst |
Metodos y composicion para la produccion de pares trna-aminoaciltrna sintetasa ortogonales.
|
|
AU2002330714A1
(en)
|
2001-05-30 |
2003-01-02 |
Biomedical Center |
In silico screening for phenotype-associated expressed sequences
|
|
JP2005508614A
(ja)
|
2001-07-06 |
2005-04-07 |
インサイト・ゲノミックス・インコーポレイテッド |
薬物代謝酵素
|
|
ATE432981T1
(de)
|
2001-07-26 |
2009-06-15 |
Stratagene California |
Multi-stellen-mutagenese
|
|
US20040028687A1
(en)
|
2002-01-15 |
2004-02-12 |
Waelti Ernst Rudolf |
Methods and compositions for the targeted delivery of therapeutic substances to specific cells and tissues
|
|
US20030167533A1
(en)
|
2002-02-04 |
2003-09-04 |
Yadav Narendra S. |
Intein-mediated protein splicing
|
|
FR2837837B1
(fr)
|
2002-03-28 |
2006-09-29 |
Roussy Inst Gustave |
Epitopes peptidiques communs a des antigenes d'une meme famille multigenique
|
|
DK1506288T3
(da)
|
2002-05-10 |
2013-07-22 |
Medical Res Council |
Aktiveringsinduceret deaminase (aid)
|
|
US9045727B2
(en)
|
2002-05-17 |
2015-06-02 |
Emory University |
Virus-like particles, methods of preparation, and immunogenic compositions
|
|
WO2003104413A2
(en)
|
2002-06-05 |
2003-12-18 |
University Of Florida |
Production of pseudotyped recombinant aav virions
|
|
US9388459B2
(en)
|
2002-06-17 |
2016-07-12 |
Affymetrix, Inc. |
Methods for genotyping
|
|
EP1578932A4
(en)
|
2002-07-12 |
2006-08-30 |
Affymetrix Inc |
SYNTHETIC MARKER GENES
|
|
CA2495881C
(en)
|
2002-08-19 |
2014-07-08 |
The President And Fellows Of Harvard College |
Evolving new molecular function
|
|
EP2233494A3
(en)
|
2002-09-20 |
2013-05-29 |
Yale University |
Riboswitches, methods for their use, and compositions for use with riboswitches
|
|
US20090183270A1
(en)
|
2002-10-02 |
2009-07-16 |
Adams Thomas R |
Transgenic plants with enhanced agronomic traits
|
|
EP1562550A1
(en)
|
2002-11-21 |
2005-08-17 |
Pevion Biotech Ltd. |
High-efficiency fusogenic vesicles, methods of producing them, and pharmaceutical compositions containing them
|
|
US8017323B2
(en)
|
2003-03-26 |
2011-09-13 |
President And Fellows Of Harvard College |
Free reactant use in nucleic acid-templated synthesis
|
|
WO2004092733A1
(en)
|
2003-04-14 |
2004-10-28 |
Caliper Life Sciences, Inc. |
Reduction of migration shift assay interference
|
|
US8017755B2
(en)
|
2003-05-23 |
2011-09-13 |
President And Fellows Of Harvard College |
RNA-based transcriptional regulators
|
|
US20050136429A1
(en)
|
2003-07-03 |
2005-06-23 |
Massachusetts Institute Of Technology |
SIRT1 modulation of adipogenesis and adipose function
|
|
ATE386133T1
(de)
|
2003-07-07 |
2008-03-15 |
Scripps Research Inst |
Zusammensetzungen der orthogonalen lysyl-trna und aminoacyl-trna synthetase paaren und ihre verwendungen
|
|
JP4555292B2
(ja)
|
2003-08-08 |
2010-09-29 |
サンガモ バイオサイエンシズ インコーポレイテッド |
標的化された切断及び組換えの方法及び組成物
|
|
AU2004294345B2
(en)
|
2003-12-01 |
2012-02-23 |
Sloan-Kettering Institute For Cancer Research |
Synthetic HLA binding peptide analogues and uses thereof
|
|
WO2005058937A2
(en)
|
2003-12-12 |
2005-06-30 |
Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services |
A human cytotoxic t-lymphocyte epitope and its agonist epitope from the non-variable number of tandem repeat sequence of muc-1
|
|
US7670807B2
(en)
|
2004-03-10 |
2010-03-02 |
East Tennessee State Univ. Research Foundation |
RNA-dependent DNA polymerase from Geobacillus stearothermophilus
|
|
US7192739B2
(en)
|
2004-03-30 |
2007-03-20 |
President And Fellows Of Harvard College |
Ligand-dependent protein splicing
|
|
US7595179B2
(en)
|
2004-04-19 |
2009-09-29 |
Applied Biosystems, Llc |
Recombinant reverse transcriptases
|
|
US7919277B2
(en)
|
2004-04-28 |
2011-04-05 |
Danisco A/S |
Detection and typing of bacterial strains
|
|
US7476734B2
(en)
|
2005-12-06 |
2009-01-13 |
Helicos Biosciences Corporation |
Nucleotide analogs
|
|
CA2571168A1
(en)
|
2004-06-17 |
2006-01-26 |
Mannkind Corporation |
Mhc i-binding ssx-241-49 variants
|
|
WO2006002547A1
(en)
|
2004-07-06 |
2006-01-12 |
UNIVERSITé DE SHERBROOKE |
A target-dependent nucleic acid adapter
|
|
US7851658B2
(en)
|
2004-08-17 |
2010-12-14 |
President And Fellows Of Harvard College |
Palladium-catalyzed carbon-carbon bond forming reactions
|
|
WO2006023207A2
(en)
|
2004-08-19 |
2006-03-02 |
The United States Of America As Represented By The Secretary Of Health And Human Services, Nih |
Coacervate of anionic and cationic polymer forming microparticles for the sustained release of therapeutic agents
|
|
WO2006042112A2
(en)
|
2004-10-05 |
2006-04-20 |
California Institute Of Technology |
Aptamer regulated nucleic acids and uses thereof
|
|
US9034650B2
(en)
|
2005-02-02 |
2015-05-19 |
Intrexon Corporation |
Site-specific serine recombinases and methods of their use
|
|
US8178291B2
(en)
|
2005-02-18 |
2012-05-15 |
Monogram Biosciences, Inc. |
Methods and compositions for determining hypersusceptibility of HIV-1 to non-nucleoside reverse transcriptase inhibitors
|
|
JP2006248978A
(ja)
|
2005-03-10 |
2006-09-21 |
Mebiopharm Co Ltd |
新規なリポソーム製剤
|
|
WO2006138666A2
(en)
|
2005-06-17 |
2006-12-28 |
President And Fellows Of Harvard College |
Iterated branching reaction pathways via nucleic acid-mediated chemistry
|
|
CA2612494A1
(en)
|
2005-06-17 |
2006-12-28 |
Mannkind Corporation |
Epitope analogues
|
|
WO2007011722A2
(en)
|
2005-07-15 |
2007-01-25 |
President And Fellows Of Harvard College |
Reaction discovery system
|
|
US9783791B2
(en)
|
2005-08-10 |
2017-10-10 |
Agilent Technologies, Inc. |
Mutant reverse transcriptase and methods of use
|
|
AU2012244264B2
(en)
|
2005-08-26 |
2015-08-06 |
Dupont Nutrition Biosciences Aps |
Use
|
|
WO2007025097A2
(en)
|
2005-08-26 |
2007-03-01 |
Danisco A/S |
Use
|
|
AU2015252023B2
(en)
|
2005-08-26 |
2017-06-29 |
Dupont Nutrition Biosciences Aps |
Use
|
|
US20080241917A1
(en)
|
2005-09-30 |
2008-10-02 |
Hidetaka Akita |
Vector For Delivering Target Substance Into Nucleus or Cell
|
|
KR100784478B1
(ko)
|
2005-12-05 |
2007-12-11 |
한국과학기술원 |
기능요소의 동시 삽입에 의한 신기능을 갖는 단백질을제조하는 방법
|
|
US20080051317A1
(en)
|
2005-12-15 |
2008-02-28 |
George Church |
Polypeptides comprising unnatural amino acids, methods for their production and uses therefor
|
|
WO2007099387A1
(en)
|
2006-03-03 |
2007-09-07 |
Mymetics Corporation |
Virosome-like vesicles comprising gp41-derived antigens
|
|
US9085778B2
(en)
|
2006-05-03 |
2015-07-21 |
VL27, Inc. |
Exosome transfer of nucleic acids to cells
|
|
CA2651389C
(en)
|
2006-05-05 |
2017-04-25 |
Molecular Transfer, Inc. |
Novel reagents for transfection of eukaryotic cells
|
|
ATE530669T1
(de)
|
2006-05-19 |
2011-11-15 |
Danisco |
Markierte mikroorganismen und entsprechende markierungsverfahren
|
|
US9150626B2
(en)
|
2006-06-02 |
2015-10-06 |
President And Fellows Of Harvard College |
Protein surface remodeling
|
|
US8129115B2
(en)
|
2006-06-06 |
2012-03-06 |
Panasonic Corporation |
Method of modifying nucleotide chain
|
|
US7572618B2
(en)
|
2006-06-30 |
2009-08-11 |
Bristol-Myers Squibb Company |
Polynucleotides encoding novel PCSK9 variants
|
|
WO2008005529A2
(en)
|
2006-07-07 |
2008-01-10 |
The Trustees Columbia University In The City Of New York |
Cell-mediated directed evolution
|
|
US20120322861A1
(en)
|
2007-02-23 |
2012-12-20 |
Barry John Byrne |
Compositions and Methods for Treating Diseases
|
|
NZ592231A
(en)
|
2007-03-02 |
2012-07-27 |
Danisco |
Methods to generate bacteriophage resistant bacterial strains and produce bacteriophage CRISPR loci phage mutants
|
|
WO2009002418A2
(en)
|
2007-06-21 |
2008-12-31 |
Merck & Co., Inc. |
T-cell peptide epitopes from carcinoembryonic antigen, immunogenic analogs, and uses thereof
|
|
CN102083462B
(zh)
|
2007-08-03 |
2015-02-18 |
巴斯德研究院 |
慢病毒基因转移载体及其医学应用
|
|
FR2919804B1
(fr)
|
2007-08-08 |
2010-08-27 |
Erytech Pharma |
Composition et vaccin therapeutique anti-tumoral
|
|
WO2009033027A2
(en)
|
2007-09-05 |
2009-03-12 |
Medtronic, Inc. |
Suppression of scn9a gene expression and/or function for the treatment of pain
|
|
EP2036980A1
(de)
|
2007-09-14 |
2009-03-18 |
Gruber, Jens |
Herabregulation der Genexpression mittels Nukleinsäure-beladener virusähnlicher Partikel
|
|
WO2009042163A2
(en)
|
2007-09-27 |
2009-04-02 |
Sangamo Biosciences, Inc. |
Rapid in vivo identification of biologically active nucleases
|
|
US9029524B2
(en)
|
2007-12-10 |
2015-05-12 |
California Institute Of Technology |
Signal activated RNA interference
|
|
EP2087789A1
(en)
|
2008-02-06 |
2009-08-12 |
Heinrich-Heine-Universität Düsseldorf |
Fto-modified non-human mammal
|
|
CA2714378A1
(en)
|
2008-02-08 |
2009-08-13 |
Sangamo Biosciences, Inc. |
Treatment of chronic pain with zinc finger proteins
|
|
GB0806562D0
(en)
|
2008-04-10 |
2008-05-14 |
Fermentas Uab |
Production of nucleic acid
|
|
WO2009146179A1
(en)
|
2008-04-15 |
2009-12-03 |
University Of Iowa Research Foundation |
Zinc finger nuclease for the cftr gene and methods of use thereof
|
|
CN102066405B
(zh)
|
2008-04-28 |
2015-09-30 |
哈佛大学校长及研究员协会 |
用于细胞穿透的超荷电蛋白
|
|
US8394604B2
(en)
|
2008-04-30 |
2013-03-12 |
Paul Xiang-Qin Liu |
Protein splicing using short terminal split inteins
|
|
US8546553B2
(en)
|
2008-07-25 |
2013-10-01 |
University Of Georgia Research Foundation, Inc. |
Prokaryotic RNAi-like system and methods of use
|
|
FR2934346B1
(fr)
|
2008-07-28 |
2010-09-03 |
Claude Benit |
Valve pour installation sanitaire et dispositif multifonction pour appareil sanitaire comprenant une telle valve
|
|
JP2010033344A
(ja)
|
2008-07-29 |
2010-02-12 |
Azabu Jui Gakuen |
核酸構成塩基の偏在性を表す方法
|
|
EP2159286A1
(en)
|
2008-09-01 |
2010-03-03 |
Consiglio Nazionale Delle Ricerche |
Method for obtaining oligonucleotide aptamers and uses thereof
|
|
EP2331071A1
(en)
|
2008-09-05 |
2011-06-15 |
Institut National De La Sante Et De La Recherche Medicale |
Novel multimodular assembly useful for intracellular delivery
|
|
US9023594B2
(en)
|
2008-09-05 |
2015-05-05 |
President And Fellows Of Harvard College |
Continuous directed evolution of proteins and nucleic acids
|
|
US8636884B2
(en)
|
2008-09-15 |
2014-01-28 |
Abbott Diabetes Care Inc. |
Cationic polymer based wired enzyme formulations for use in analyte sensors
|
|
US20100076057A1
(en)
|
2008-09-23 |
2010-03-25 |
Northwestern University |
TARGET DNA INTERFERENCE WITH crRNA
|
|
US9296790B2
(en)
|
2008-10-03 |
2016-03-29 |
The United States Of America, As Represented By The Secretary, Department Of Health And Human Services |
Methods and compositions for protein delivery
|
|
DE102008050860A1
(de)
|
2008-10-08 |
2010-04-15 |
Dorothee Von Laer |
LCMV-GP-VSV-Pseudotypvektoren und tumorinfiltrierende Virenproduzentenzellen zur Therapie von Tumoren
|
|
US9404098B2
(en)
|
2008-11-06 |
2016-08-02 |
University Of Georgia Research Foundation, Inc. |
Method for cleaving a target RNA using a Cas6 polypeptide
|
|
EP2362915B1
(en)
|
2008-11-07 |
2016-12-21 |
DuPont Nutrition Biosciences ApS |
Bifidobacteria crispr sequences
|
|
US20110016540A1
(en)
|
2008-12-04 |
2011-01-20 |
Sigma-Aldrich Co. |
Genome editing of genes associated with trinucleotide repeat expansion disorders in animals
|
|
AU2009325069B2
(en)
|
2008-12-11 |
2015-03-19 |
Pacific Biosciences Of California, Inc. |
Classification of nucleic acid templates
|
|
US9175338B2
(en)
|
2008-12-11 |
2015-11-03 |
Pacific Biosciences Of California, Inc. |
Methods for identifying nucleic acid modifications
|
|
WO2010075424A2
(en)
|
2008-12-22 |
2010-07-01 |
The Regents Of University Of California |
Compositions and methods for downregulating prokaryotic genes
|
|
KR101544245B1
(ko)
|
2009-02-03 |
2015-08-12 |
아뮤닉스 오퍼레이팅 인코포레이티드 |
연장된 재조합 폴리펩티드 및 이를 포함하는 조성물
|
|
US20130022980A1
(en)
|
2009-02-04 |
2013-01-24 |
Lucigen Corporation |
Rna- and dna-copying enzymes
|
|
WO2010091294A2
(en)
|
2009-02-05 |
2010-08-12 |
The Regents Of The University Of California |
New targeted antimicrobial moieties
|
|
US20100305197A1
(en)
|
2009-02-05 |
2010-12-02 |
Massachusetts Institute Of Technology |
Conditionally Active Ribozymes And Uses Thereof
|
|
CA2754476A1
(en)
|
2009-03-04 |
2010-09-10 |
Alan M. Lambowitz |
Stabilized reverse transcriptase fusion proteins
|
|
SG10201400436PA
(en)
|
2009-03-06 |
2014-06-27 |
Synthetic Genomics Inc |
Methods For Cloning And Manipulating Genomes
|
|
CA2754764A1
(en)
|
2009-03-10 |
2010-09-16 |
Baylor Research Institute |
Antigen presenting cell targeted cancer vaccines
|
|
CN102497887A
(zh)
|
2009-04-17 |
2012-06-13 |
Isis创新公司 |
递送遗传物质的组合物
|
|
CA2760155A1
(en)
|
2009-04-27 |
2010-11-11 |
Pacific Biosciences Of California, Inc. |
Real-time sequencing methods and systems
|
|
WO2010129023A2
(en)
|
2009-04-28 |
2010-11-11 |
President And Fellows Of Harvard College |
Supercharged proteins for cell penetration
|
|
WO2010132092A2
(en)
|
2009-05-12 |
2010-11-18 |
The Scripps Research Institute |
Cytidine deaminase fusions and related methods
|
|
US9063156B2
(en)
|
2009-06-12 |
2015-06-23 |
Pacific Biosciences Of California, Inc. |
Real-time analytical methods and systems
|
|
WO2011002503A1
(en)
|
2009-06-30 |
2011-01-06 |
Sangamo Biosciences, Inc. |
Rapid screening of biologically active nucleases and isolation of nuclease-modified cells
|
|
US8569256B2
(en)
|
2009-07-01 |
2013-10-29 |
Protiva Biotherapeutics, Inc. |
Cationic lipids and methods for the delivery of therapeutic agents
|
|
AU2010279572B2
(en)
|
2009-08-03 |
2017-02-02 |
Recombinetics, Inc. |
Methods and compositions for targeted gene modification
|
|
WO2011017293A2
(en)
|
2009-08-03 |
2011-02-10 |
The General Hospital Corporation |
Engineering of zinc finger arrays by context-dependent assembly
|
|
GB0913681D0
(en)
|
2009-08-05 |
2009-09-16 |
Glaxosmithkline Biolog Sa |
Immunogenic composition
|
|
US8889394B2
(en)
|
2009-09-07 |
2014-11-18 |
Empire Technology Development Llc |
Multiple domain proteins
|
|
MX2012005069A
(es)
|
2009-10-30 |
2012-07-17 |
Synthetic Genomics Inc |
Codificar texto hacia secuencias de acido nucleico.
|
|
JP6199033B2
(ja)
|
2009-11-02 |
2017-09-20 |
ユニヴァーシティ オブ ワシントン |
治療用ヌクレアーゼ組成物および方法
|
|
US9175340B2
(en)
|
2009-11-04 |
2015-11-03 |
President And Fellows Of Harvard College |
Reactivity-dependent and interaction-dependent PCR
|
|
US20110104787A1
(en)
|
2009-11-05 |
2011-05-05 |
President And Fellows Of Harvard College |
Fusion Peptides That Bind to and Modify Target Nucleic Acid Sequences
|
|
ES2693167T3
(es)
|
2009-11-13 |
2018-12-07 |
Inserm - Institut National De La Santé Et De La Recherche Médicale |
Administración directa de proteínas con microvesículas modificadas por ingeniería
|
|
SI3338765T1
(sl)
|
2009-12-01 |
2019-05-31 |
Translate Bio, Inc. |
Derivat steroida za dostavo MRNA pri humanih genetskih boleznih
|
|
WO2011068916A1
(en)
|
2009-12-01 |
2011-06-09 |
Intezyne Technologies, Incorporated |
Pegylated polyplexes for polynucleotide delivery
|
|
WO2011072246A2
(en)
|
2009-12-10 |
2011-06-16 |
Regents Of The University Of Minnesota |
Tal effector-mediated dna modification
|
|
EP2513296A4
(en)
|
2009-12-18 |
2013-05-22 |
Univ Leland Stanford Junior |
USE OF CYTIDINE DAMINASE ASSOCIATED ACTIVITIES TO PROMOTE DEMETHYLATION AND CELL REPROGRAMMEIRING
|
|
CN102843904B
(zh)
|
2010-01-22 |
2015-01-21 |
陶氏益农公司 |
在经遗传修饰的生物体中切除转基因
|
|
EA031322B1
(ru)
|
2010-01-22 |
2018-12-28 |
Дау Агросайенсиз Ллс |
Клетка или клеточная линия для экспрессии экзогенных нуклеотидных последовательностей и применение клетки или клеточной линии
|
|
WO2011091396A1
(en)
|
2010-01-25 |
2011-07-28 |
Alnylam Pharmaceuticals, Inc. |
Compositions and methods for inhibiting expression of mylip/idol gene
|
|
US20110206672A1
(en)
|
2010-02-25 |
2011-08-25 |
Melvyn Little |
Antigen-Binding Molecule And Uses Thereof
|
|
EP2542676A1
(en)
|
2010-03-05 |
2013-01-09 |
Synthetic Genomics, Inc. |
Methods for cloning and manipulating genomes
|
|
GB201004575D0
(en)
|
2010-03-19 |
2010-05-05 |
Immatics Biotechnologies Gmbh |
Composition of tumor associated peptides and related anti cancer vaccine for the treatment of gastric cancer and other cancers
|
|
US8557961B2
(en)
|
2010-04-02 |
2013-10-15 |
Amunix Operating Inc. |
Alpha 1-antitrypsin compositions and methods of making and using same
|
|
US9314516B2
(en)
|
2010-05-04 |
2016-04-19 |
Cassian Yee |
Conditional superagonist CTL ligands for the promotion of tumor-specific CTL responses
|
|
CN103038338B
(zh)
|
2010-05-10 |
2017-03-08 |
加利福尼亚大学董事会 |
核糖核酸内切酶组合物及其使用方法
|
|
AU2011256838B2
(en)
|
2010-05-17 |
2014-10-09 |
Sangamo Therapeutics, Inc. |
Novel DNA-binding proteins and uses thereof
|
|
GB201008267D0
(en)
|
2010-05-18 |
2010-06-30 |
Univ Edinburgh |
Cationic lipids
|
|
CN103154256A
(zh)
|
2010-05-27 |
2013-06-12 |
海因里希·佩特研究所莱比锡试验病毒学研究所-民法基金会 |
用于使多种逆转录病毒毒株中的不对称靶位点重组的修整重组酶
|
|
WO2011153120A1
(en)
|
2010-06-04 |
2011-12-08 |
Merck Sharp & Dohme Corp. |
Novel low molecular weight cationic lipids for oligonucleotide delivery
|
|
EP2392208B1
(en)
|
2010-06-07 |
2016-05-04 |
Helmholtz Zentrum München Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH) |
Fusion proteins comprising a DNA-binding domain of a Tal effector protein and a non-specific cleavage domain of a restriction nuclease and their use
|
|
AU2011265733B2
(en)
|
2010-06-14 |
2014-04-17 |
Iowa State University Research Foundation, Inc. |
Nuclease activity of TAL effector and Foki fusion protein
|
|
US8975232B2
(en)
|
2010-07-29 |
2015-03-10 |
President And Fellows Of Harvard College |
Macrocyclic kinase inhibitors and uses thereof
|
|
CA2807552A1
(en)
|
2010-08-06 |
2012-02-09 |
Moderna Therapeutics, Inc. |
Engineered nucleic acids and methods of use thereof
|
|
JPWO2012020759A1
(ja)
|
2010-08-13 |
2013-10-28 |
国立大学法人京都大学 |
変異型逆転写酵素
|
|
ES2833075T3
(es)
|
2010-09-20 |
2021-06-14 |
Spi Pharma Inc |
Procedimiento de microencapsulación y producto
|
|
WO2012054726A1
(en)
|
2010-10-20 |
2012-04-26 |
Danisco A/S |
Lactococcus crispr-cas sequences
|
|
US9458484B2
(en)
|
2010-10-22 |
2016-10-04 |
Bio-Rad Laboratories, Inc. |
Reverse transcriptase mixtures with improved storage stability
|
|
US9405700B2
(en)
|
2010-11-04 |
2016-08-02 |
Sonics, Inc. |
Methods and apparatus for virtualization in an integrated circuit
|
|
SI2635257T1
(en)
|
2010-11-05 |
2018-01-31 |
Novavax, Inc. |
RABIES GLYCOPROTEIN VIRUS-LIKE PARTICLES (VLPs)
|
|
US20140005269A1
(en)
|
2010-11-26 |
2014-01-02 |
University Of The Witwatersrand, Johannesburg |
Polymeric matrix of polymer-lipid nanoparticles as a pharmaceutical dosage form
|
|
KR101255338B1
(ko)
|
2010-12-15 |
2013-04-16 |
포항공과대학교 산학협력단 |
표적 세포에 대한 폴리뉴클레오티드 전달체
|
|
WO2012083017A2
(en)
|
2010-12-16 |
2012-06-21 |
Celgene Corporation |
Controlled release oral dosage forms of poorly soluble drugs and uses thereof
|
|
JP6088438B2
(ja)
|
2010-12-22 |
2017-03-01 |
プレジデント アンド フェローズ オブ ハーバード カレッジ |
連続的定向進化
|
|
US9499592B2
(en)
|
2011-01-26 |
2016-11-22 |
President And Fellows Of Harvard College |
Transcription activator-like effectors
|
|
KR101818126B1
(ko)
|
2011-02-09 |
2018-01-15 |
(주)바이오니아 |
열안정성이 증가된 역전사효소
|
|
US9528124B2
(en)
|
2013-08-27 |
2016-12-27 |
Recombinetics, Inc. |
Efficient non-meiotic allele introgression
|
|
US20140201857A1
(en)
|
2013-01-14 |
2014-07-17 |
Recombinetics, Inc. |
Hornless livestock
|
|
US9200045B2
(en)
|
2011-03-11 |
2015-12-01 |
President And Fellows Of Harvard College |
Small molecule-dependent inteins and uses thereof
|
|
US9164079B2
(en)
|
2011-03-17 |
2015-10-20 |
Greyledge Technologies Llc |
Systems for autologous biological therapeutics
|
|
US20120244601A1
(en)
|
2011-03-22 |
2012-09-27 |
Bertozzi Carolyn R |
Riboswitch based inducible gene expression platform
|
|
JP2012210172A
(ja)
|
2011-03-30 |
2012-11-01 |
Japan Science & Technology Agency |
外部環境に応答して内部の物質組成を変えるリポソーム
|
|
US8709466B2
(en)
|
2011-03-31 |
2014-04-29 |
International Business Machines Corporation |
Cationic polymers for antimicrobial applications and delivery of bioactive materials
|
|
EP3320910A1
(en)
|
2011-04-05 |
2018-05-16 |
Cellectis |
Method for the generation of compact tale-nucleases and uses thereof
|
|
WO2012138487A2
(en)
|
2011-04-07 |
2012-10-11 |
The Board Of Regents Of The University Of Texas System |
Oligonucleotide modulation of splicing
|
|
US10092660B2
(en)
|
2011-04-25 |
2018-10-09 |
Stc.Unm |
Solid compositions for pharmaceutical use
|
|
AU2012249390B2
(en)
|
2011-04-27 |
2017-03-30 |
Amyris, Inc. |
Methods for genomic modification
|
|
US8691750B2
(en)
|
2011-05-17 |
2014-04-08 |
Axolabs Gmbh |
Lipids and compositions for intracellular delivery of biologically active compounds
|
|
WO2012158985A2
(en)
|
2011-05-17 |
2012-11-22 |
Transposagen Biopharmaceuticals, Inc. |
Methods for site-specific genetic modification in spermatogonial stem cells using zinc finger nuclease (zfn) for the creation of model organisms
|
|
WO2012158986A2
(en)
|
2011-05-17 |
2012-11-22 |
Transposagen Biopharmaceuticals, Inc. |
Methods for site-specific genetic modification in stem cells using xanthomonas tal nucleases (xtn) for the creation of model organisms
|
|
US20140113376A1
(en)
|
2011-06-01 |
2014-04-24 |
Rotem Sorek |
Compositions and methods for downregulating prokaryotic genes
|
|
WO2012170930A1
(en)
|
2011-06-08 |
2012-12-13 |
Shire Human Genetic Therapies, Inc |
Lipid nanoparticle compositions and methods for mrna delivery
|
|
CA2843853A1
(en)
|
2011-07-01 |
2013-01-10 |
President And Fellows Of Harvard College |
Macrocyclic insulin-degrading enzyme (ide) inhibitors and uses thereof
|
|
JP6214530B2
(ja)
|
2011-07-15 |
2017-10-18 |
ザ ジェネラル ホスピタル コーポレイション |
転写活性化因子様エフェクターの組立て方法
|
|
CN103857797A
(zh)
|
2011-07-19 |
2014-06-11 |
帷幄生物技术公司 |
用于修复软骨损伤的非遗传修饰性重编程细胞的组合物和方法
|
|
US10323236B2
(en)
|
2011-07-22 |
2019-06-18 |
President And Fellows Of Harvard College |
Evaluation and improvement of nuclease cleavage specificity
|
|
EP2755986A4
(en)
|
2011-09-12 |
2015-05-20 |
Moderna Therapeutics Inc |
MANIPULATED NUCLEIC ACIDS AND METHOD OF APPLICATION THEREFOR
|
|
DK2755675T3
(en)
|
2011-09-12 |
2018-08-06 |
Amunix Operating Inc |
Glucagon-like peptide-2 compositions and methods for their preparation and use
|
|
EP3384938A1
(en)
|
2011-09-12 |
2018-10-10 |
Moderna Therapeutics, Inc. |
Engineered nucleic acids and methods of use thereof
|
|
EP2761006B1
(en)
|
2011-09-28 |
2016-12-14 |
Zera Intein Protein Solutions, S.L. |
Split inteins and uses thereof
|
|
AU2012317323B2
(en)
|
2011-09-28 |
2017-10-05 |
Fujimoto Pharmaceutical Corporation |
NGF aptamer and application thereof
|
|
EP2583974B1
(en)
|
2011-10-21 |
2017-04-26 |
Technische Universität Dresden |
Pseudotyping of foamy viruses
|
|
CN103088008B
(zh)
*
|
2011-10-31 |
2014-08-20 |
中国科学院微生物研究所 |
胞苷脱氨酶及其编码基因和它们的应用
|
|
ES2874233T3
(es)
|
2011-11-11 |
2021-11-04 |
Variation Biotechnologies Inc |
Composiciones y métodos para el tratamiento de citomegalovirus
|
|
US9326992B2
(en)
|
2011-12-08 |
2016-05-03 |
Sarepta Therapeutics, Inc. |
Methods for treating progeroid laminopathies using oligonucleotide analogues targeting human LMNA
|
|
US11458157B2
(en)
|
2011-12-16 |
2022-10-04 |
Targetgene Biotechnologies Ltd. |
Compositions and methods for modifying a predetermined target nucleic acid sequence
|
|
RU2649364C2
(ru)
|
2011-12-16 |
2018-04-02 |
Модерна Терапьютикс, Инк. |
Составы на основе модифицированного нуклеозида, нуклеотида и нуклеиновой кислоты
|
|
GB201122458D0
(en)
|
2011-12-30 |
2012-02-08 |
Univ Wageningen |
Modified cascade ribonucleoproteins and uses thereof
|
|
WO2013119602A1
(en)
|
2012-02-06 |
2013-08-15 |
President And Fellows Of Harvard College |
Arrdc1-mediated microvesicles (armms) and uses thereof
|
|
WO2013120022A2
(en)
|
2012-02-08 |
2013-08-15 |
Seneb Biosciences, Inc. |
Treatment of hypoglycemia
|
|
EP3564260B1
(en)
|
2012-02-15 |
2022-10-19 |
Bioverativ Therapeutics Inc. |
Factor viii compositions and methods of making and using same
|
|
NZ630900A
(en)
|
2012-02-24 |
2016-10-28 |
Hutchinson Fred Cancer Res |
Compositions and methods for the treatment of hemoglobinopathies
|
|
MX366864B
(es)
|
2012-02-27 |
2019-07-26 |
Amunix Operating Inc |
Composiciones de conjugados de xten y métodos para realizarlas.
|
|
AU2013225950B2
(en)
|
2012-02-29 |
2018-02-15 |
Sangamo Therapeutics, Inc. |
Methods and compositions for treating huntington's disease
|
|
WO2013142378A1
(en)
|
2012-03-17 |
2013-09-26 |
The Regents Of The University Of California |
Fast diagnosis and personalized treatments for acne
|
|
US9637739B2
(en)
|
2012-03-20 |
2017-05-02 |
Vilnius University |
RNA-directed DNA cleavage by the Cas9-crRNA complex
|
|
WO2013141680A1
(en)
|
2012-03-20 |
2013-09-26 |
Vilnius University |
RNA-DIRECTED DNA CLEAVAGE BY THE Cas9-crRNA COMPLEX
|
|
WO2013152359A1
(en)
|
2012-04-06 |
2013-10-10 |
The Regents Of The University Of California |
Novel tetrazines and method of synthesizing the same
|
|
CA2871008C
(en)
|
2012-04-23 |
2022-11-22 |
Bayer Cropscience Nv |
Targeted genome engineering in plants
|
|
MX344903B
(es)
|
2012-05-02 |
2017-01-11 |
Dow Agrosciences Llc |
Modificación dirigida de deshidrogenasa de malato.
|
|
HK1208051A1
(en)
|
2012-05-07 |
2016-02-19 |
桑格摩生物科学股份有限公司 |
Methods and compositions for nuclease-mediated targeted integration of transgenes
|
|
US11120889B2
(en)
|
2012-05-09 |
2021-09-14 |
Georgia Tech Research Corporation |
Method for synthesizing a nuclease with reduced off-site cleavage
|
|
US20160046961A1
(en)
|
2012-05-25 |
2016-02-18 |
Emmanuelle Charpentier |
Methods and Compositions for RNA-Directed Target DNA Modification and For RNA-Directed Modulation of Transcription
|
|
PT2855667T
(pt)
|
2012-05-25 |
2023-11-22 |
Cellectis |
Métodos para modificar geneticamente células t alogénicas e resistentes a imunossupressores para imunoterapia
|
|
US20150017136A1
(en)
|
2013-07-15 |
2015-01-15 |
Cellectis |
Methods for engineering allogeneic and highly active t cell for immunotherapy
|
|
EP2854866A4
(en)
|
2012-05-30 |
2015-12-23 |
Baylor College Medicine |
SUPERHELIC MINI-SECTORS AS A TOOL FOR DNS REPAIR, CHANGE AND REPLACEMENT
|
|
US9102936B2
(en)
|
2012-06-11 |
2015-08-11 |
Agilent Technologies, Inc. |
Method of adaptor-dimer subtraction using a CRISPR CAS6 protein
|
|
CN104540382A
(zh)
|
2012-06-12 |
2015-04-22 |
弗·哈夫曼-拉罗切有限公司 |
用于产生条件性敲除等位基因的方法和组合物
|
|
EP2674501A1
(en)
|
2012-06-14 |
2013-12-18 |
Agence nationale de sécurité sanitaire de l'alimentation,de l'environnement et du travail |
Method for detecting and identifying enterohemorrhagic Escherichia coli
|
|
WO2013188638A2
(en)
|
2012-06-15 |
2013-12-19 |
The Regents Of The University Of California |
Endoribonucleases and methods of use thereof
|
|
WO2013192278A1
(en)
|
2012-06-19 |
2013-12-27 |
Regents Of The University Of Minnesota |
Gene targeting in plants using dna viruses
|
|
US9267127B2
(en)
|
2012-06-21 |
2016-02-23 |
President And Fellows Of Harvard College |
Evolution of bond-forming enzymes
|
|
US20150344549A1
(en)
|
2012-06-27 |
2015-12-03 |
The Trustees Of Princeton University |
Split inteins, conjugates and uses thereof
|
|
SG11201408736SA
(en)
|
2012-06-29 |
2015-03-30 |
Massachusetts Inst Technology |
Massively parallel combinatorial genetics
|
|
US9125508B2
(en)
|
2012-06-30 |
2015-09-08 |
Seasons 4, Inc. |
Collapsible tree system
|
|
DK3444342T3
(da)
|
2012-07-11 |
2020-08-24 |
Sangamo Therapeutics Inc |
Fremgangsmåder og sammensætninger til behandlingen af lysosomale aflejringssygdomme
|
|
EP2872154B1
(en)
|
2012-07-11 |
2017-05-31 |
Sangamo BioSciences, Inc. |
Methods and compositions for delivery of biologics
|
|
JP2015527889A
(ja)
|
2012-07-25 |
2015-09-24 |
ザ ブロード インスティテュート, インコーポレイテッド |
誘導可能なdna結合タンパク質およびゲノム撹乱ツール、ならびにそれらの適用
|
|
US10058078B2
(en)
|
2012-07-31 |
2018-08-28 |
Recombinetics, Inc. |
Production of FMDV-resistant livestock by allele substitution
|
|
HK1205453A1
(en)
|
2012-07-31 |
2015-12-18 |
Yeda Research And Development Co. Ltd. |
Methods of diagnosing and treating motor neuron diseases
|
|
HK1207111A1
(en)
|
2012-08-03 |
2016-01-22 |
加利福尼亚大学董事会 |
Methods and compositions for controlling gene expression by rna processing
|
|
IN2015DN01480A
(enExample)
|
2012-08-29 |
2015-07-03 |
Sangamo Biosciences Inc |
|
|
DK2893004T3
(en)
|
2012-09-04 |
2019-02-04 |
Cellectis |
MULTI-CHAIN CHEMICAL ANTIGEN RECEPTOR AND APPLICATIONS THEREOF
|
|
WO2014039585A2
(en)
|
2012-09-04 |
2014-03-13 |
The Scripps Research Institute |
Chimeric polypeptides having targeted binding specificity
|
|
US9937205B2
(en)
|
2012-09-04 |
2018-04-10 |
The Trustees Of The University Of Pennsylvania |
Inhibition of diacylglycerol kinase to augment adoptive T cell transfer
|
|
UA118090C2
(uk)
|
2012-09-07 |
2018-11-26 |
ДАУ АГРОСАЙЄНСІЗ ЕлЕлСі |
Спосіб інтегрування послідовності нуклеїнової кислоти, що представляє інтерес, у ген fad2 у клітині сої та специфічний для локусу fad2 білок, що зв'язується, здатний індукувати спрямований розрив
|
|
TWI670004B
(zh)
|
2012-09-07 |
2019-09-01 |
美商陶氏農業科學公司 |
用來產生植物之螢光激活細胞分選富增技術
|
|
WO2014039715A1
(en)
|
2012-09-07 |
2014-03-13 |
University Of Rochester |
Methods and compositions for site-specific labeling of peptides and proteins
|
|
EP3406715B1
(en)
|
2012-09-07 |
2023-12-13 |
Corteva Agriscience LLC |
Fad3 performance loci and corresponding target site specific binding proteins capable of inducing targeted breaks
|
|
UA119135C2
(uk)
|
2012-09-07 |
2019-05-10 |
ДАУ АГРОСАЙЄНСІЗ ЕлЕлСі |
Спосіб отримання трансгенної рослини
|
|
WO2014043143A1
(en)
|
2012-09-11 |
2014-03-20 |
Life Technologies Corporation |
Nucleic acid amplification
|
|
GB201216564D0
(en)
|
2012-09-17 |
2012-10-31 |
Univ Edinburgh |
Genetically edited animal
|
|
WO2014047103A2
(en)
|
2012-09-18 |
2014-03-27 |
The Translational Genomics Research Institute |
Isolated genes and transgenic organisms for producing biofuels
|
|
US9181535B2
(en)
|
2012-09-24 |
2015-11-10 |
The Chinese University Of Hong Kong |
Transcription activator-like effector nucleases (TALENs)
|
|
EP2904101B1
(en)
|
2012-10-03 |
2019-06-12 |
Agrivida, Inc. |
Intein-modified proteases, their production and industrial applications
|
|
JO3470B1
(ar)
|
2012-10-08 |
2020-07-05 |
Merck Sharp & Dohme |
مشتقات 5- فينوكسي-3h-بيريميدين-4-أون واستخدامها كمثبطات ناسخ عكسي ل hiv
|
|
JP6401704B2
(ja)
|
2012-10-10 |
2018-10-10 |
サンガモ セラピューティクス, インコーポレイテッド |
T細胞を修飾する化合物およびその使用
|
|
EP3789405A1
(en)
|
2012-10-12 |
2021-03-10 |
The General Hospital Corporation |
Transcription activator-like effector (tale) - lysine-specific demethylase 1 (lsd1) fusion proteins
|
|
KR101706085B1
(ko)
|
2012-10-23 |
2017-02-14 |
주식회사 툴젠 |
표적 DNA에 특이적인 가이드 RNA 및 Cas 단백질을 암호화하는 핵산 또는 Cas 단백질을 포함하는, 표적 DNA를 절단하기 위한 조성물 및 이의 용도
|
|
US20140115728A1
(en)
|
2012-10-24 |
2014-04-24 |
A. Joseph Tector |
Double knockout (gt/cmah-ko) pigs, organs and tissues
|
|
CN105073981A
(zh)
|
2012-10-30 |
2015-11-18 |
重组股份有限公司 |
动物中性成熟的控制
|
|
BR112015009931A2
(pt)
|
2012-10-31 |
2017-12-05 |
Two Blades Found |
gene, proteína, molécula de ácido nucleico, vetor, célula hospedeira, métodos para a preparação in vitro de um gene mutante e para gerar uma planta, planta mutante, produto, semente de planta mutante, anticorpo, uso de um anticorpo, sonda genética, par de oligonucleotídeos iniciadores, e, uso de sonda genética
|
|
BR112015009812A2
(pt)
|
2012-10-31 |
2017-08-22 |
Cellectis |
Método para a inserção genética específica em um genoma de planta, célula de planta transformada e seu uso, planta resistente a herbicidas, kit, vetor, e célula hospedeira
|
|
WO2014071235A1
(en)
|
2012-11-01 |
2014-05-08 |
Massachusetts Institute Of Technology |
Genetic device for the controlled destruction of dna
|
|
EP3786298A1
(en)
|
2012-11-01 |
2021-03-03 |
Factor Bioscience Inc. |
Methods and products for expressing proteins in cells
|
|
US20140127752A1
(en)
|
2012-11-07 |
2014-05-08 |
Zhaohui Zhou |
Method, composition, and reagent kit for targeted genomic enrichment
|
|
JP6410237B2
(ja)
|
2012-11-09 |
2018-10-24 |
マルコ アーケッティ |
拡散性因子および癌細胞
|
|
CA2892012A1
(en)
|
2012-11-20 |
2014-05-30 |
Cold Spring Harbor Laboratory |
Mutations in solanaceae plants that modulate shoot architecture and enhance yield-related phenotypes
|
|
US20140140969A1
(en)
|
2012-11-20 |
2014-05-22 |
Sangamo Biosciences, Inc. |
Methods and compositions for muscular dystrophies
|
|
MX2015006220A
(es)
|
2012-11-20 |
2016-07-20 |
Simplot Co J R |
Insercion de adn de tranferencia mediada por efectores tipo activadores de la transcripción (tal).
|
|
DK3502240T3
(da)
|
2012-11-27 |
2021-08-09 |
Childrens Medical Ct Corp |
Målretning af distale bcl11a-reguleringselementer til føtal hæmoglobinreinduktion
|
|
CA2892551A1
(en)
|
2012-11-29 |
2014-06-05 |
North Carolina State University |
Synthetic pathway for biological carbon dioxide sequestration
|
|
EP2925866B1
(en)
|
2012-11-30 |
2018-07-25 |
Aarhus Universitet |
Circular rna for inhibition of microrna
|
|
US20160010154A1
(en)
|
2012-11-30 |
2016-01-14 |
The Parkinson's Institute |
Screening assays for therapeutics for parkinson's disease
|
|
CA2892448A1
(en)
|
2012-12-05 |
2014-06-12 |
Sangamo Biosciences, Inc. |
Methods and compositions for regulation of metabolic disorders
|
|
ES2740648T3
(es)
|
2012-12-06 |
2020-02-06 |
Synthetic Genomics Inc |
Mutantes de algas que tienen un fenotipo aclimatado a alta luz bloqueado
|
|
EP2928496B1
(en)
|
2012-12-06 |
2019-10-09 |
Sigma Aldrich Co. LLC |
Crispr-based genome modification and regulation
|
|
US9447422B2
(en)
|
2012-12-06 |
2016-09-20 |
Synthetic Genomics, Inc. |
Autonomous replication sequences and episomal DNA molecules
|
|
WO2014089348A1
(en)
|
2012-12-07 |
2014-06-12 |
Synthetic Genomics, Inc. |
Nannochloropsis spliced leader sequences and uses therefor
|
|
US10272163B2
(en)
|
2012-12-07 |
2019-04-30 |
The Regents Of The University Of California |
Factor VIII mutation repair and tolerance induction
|
|
WO2014093479A1
(en)
|
2012-12-11 |
2014-06-19 |
Montana State University |
Crispr (clustered regularly interspaced short palindromic repeats) rna-guided control of gene regulation
|
|
JP2016501531A
(ja)
|
2012-12-12 |
2016-01-21 |
ザ・ブロード・インスティテュート・インコーポレイテッド |
配列操作および治療適用のための系、方法および組成物の送達、エンジニアリングおよび最適化
|
|
CA2894668A1
(en)
|
2012-12-12 |
2014-06-19 |
The Broad Institute, Inc. |
Crispr-cas systems and methods for altering expression of gene products in eukaryotic cells
|
|
CN105209621B
(zh)
|
2012-12-12 |
2021-05-25 |
布罗德研究所有限公司 |
对用于序列操纵的改进的系统、方法和酶组合物进行的工程化和优化
|
|
WO2014093701A1
(en)
|
2012-12-12 |
2014-06-19 |
The Broad Institute, Inc. |
Functional genomics using crispr-cas systems, compositions, methods, knock out libraries and applications thereof
|
|
US8993233B2
(en)
|
2012-12-12 |
2015-03-31 |
The Broad Institute Inc. |
Engineering and optimization of systems, methods and compositions for sequence manipulation with functional domains
|
|
US20140310830A1
(en)
|
2012-12-12 |
2014-10-16 |
Feng Zhang |
CRISPR-Cas Nickase Systems, Methods And Compositions For Sequence Manipulation in Eukaryotes
|
|
CN105121648B
(zh)
|
2012-12-12 |
2021-05-07 |
布罗德研究所有限公司 |
用于序列操纵的系统、方法和优化的指导组合物的工程化
|
|
US8697359B1
(en)
|
2012-12-12 |
2014-04-15 |
The Broad Institute, Inc. |
CRISPR-Cas systems and methods for altering expression of gene products
|
|
ES2701749T3
(es)
|
2012-12-12 |
2019-02-25 |
Broad Inst Inc |
Métodos, modelos, sistemas y aparatos para identificar secuencias diana para enzimas Cas o sistemas CRISPR-Cas para secuencias diana y transmitir resultados de los mismos
|
|
EP2784162B1
(en)
|
2012-12-12 |
2015-04-08 |
The Broad Institute, Inc. |
Engineering of systems, methods and optimized guide compositions for sequence manipulation
|
|
JP6473419B2
(ja)
|
2012-12-13 |
2019-02-20 |
ダウ アグロサイエンシィズ エルエルシー |
部位特異的ヌクレアーゼ活性のdna検出方法
|
|
WO2014093852A1
(en)
|
2012-12-13 |
2014-06-19 |
Massachusetts Institute Of Technology |
Recombinase-based logic and memory systems
|
|
AU2013359091A1
(en)
|
2012-12-13 |
2015-07-02 |
Dow Agrosciences Llc |
Precision gene targeting to a particular locus in maize
|
|
US9970024B2
(en)
|
2012-12-17 |
2018-05-15 |
President And Fellows Of Harvard College |
RNA-guided human genome engineering
|
|
US9708589B2
(en)
|
2012-12-18 |
2017-07-18 |
Monsanto Technology Llc |
Compositions and methods for custom site-specific DNA recombinases
|
|
CA2895909C
(en)
|
2012-12-21 |
2021-07-06 |
Cellectis |
Potatoes with reduced cold-induced sweetening
|
|
ES2705033T3
(es)
|
2012-12-27 |
2019-03-21 |
Keygene Nv |
Método para eliminar un ligamiento genético en una planta
|
|
EP2943579B1
(en)
|
2013-01-10 |
2018-09-12 |
Dharmacon, Inc. |
Libraries and methods for generating molecules
|
|
EP3919505B1
(en)
|
2013-01-16 |
2023-08-30 |
Emory University |
Uses of cas9-nucleic acid complexes
|
|
CN103233028B
(zh)
|
2013-01-25 |
2015-05-13 |
南京徇齐生物技术有限公司 |
一种无物种限制无生物安全性问题的真核生物基因打靶方法及螺旋结构dna序列
|
|
EP2954055B1
(en)
|
2013-02-05 |
2018-04-11 |
University of Georgia Research Foundation, Inc. |
Cell lines for virus production and methods of use
|
|
US10660943B2
(en)
|
2013-02-07 |
2020-05-26 |
The Rockefeller University |
Sequence specific antimicrobials
|
|
EP2963113B1
(en)
|
2013-02-14 |
2019-11-06 |
Osaka University |
Method for isolating specific genomic region using molecule binding specifically to endogenous dna sequence
|
|
WO2014127287A1
(en)
|
2013-02-14 |
2014-08-21 |
Massachusetts Institute Of Technology |
Method for in vivo tergated mutagenesis
|
|
BR112015019950B1
(pt)
|
2013-02-20 |
2023-02-14 |
Regeneron Pharmaceuticals, Inc |
Método para gerar linhagem de células-tronco embrionárias (es) de rato, e, cultura in vitro
|
|
US20150353885A1
(en)
|
2013-02-21 |
2015-12-10 |
Cellectis |
Method to counter-select cells or organisms by linking loci to nuclease components
|
|
ES2522765B2
(es)
|
2013-02-22 |
2015-03-18 |
Universidad De Alicante |
Método para dectectar inserciones de espaciadores en estructuras CRISPR
|
|
JP6491113B2
(ja)
|
2013-02-25 |
2019-03-27 |
サンガモ セラピューティクス, インコーポレイテッド |
ヌクレアーゼ媒介性遺伝子破壊を増強するための方法および組成物
|
|
JP2016507244A
(ja)
|
2013-02-27 |
2016-03-10 |
ヘルムホルツ・ツェントルム・ミュンヒェン・ドイチェス・フォルシュンクスツェントルム・フューア・ゲズントハイト・ウント・ウムベルト(ゲーエムベーハー)Helmholtz Zentrum MuenchenDeutsches Forschungszentrum fuer Gesundheit und Umwelt (GmbH) |
Cas9ヌクレアーゼによる卵母細胞における遺伝子編集
|
|
US10047366B2
(en)
|
2013-03-06 |
2018-08-14 |
The Johns Hopkins University |
Telomerator-a tool for chromosome engineering
|
|
WO2014143381A1
(en)
|
2013-03-09 |
2014-09-18 |
Agilent Technologies, Inc. |
Methods of in vivo engineering of large sequences using multiple crispr/cas selections of recombineering events
|
|
CN105189788B
(zh)
|
2013-03-12 |
2018-07-13 |
纳幕尔杜邦公司 |
用于鉴定罕见切割工程化双链断裂诱导剂的变体识别位点的方法及其组合物和用途
|
|
EP2970886B1
(en)
|
2013-03-12 |
2018-05-23 |
Sangamo Therapeutics, Inc. |
Methods and compositions for modification of hla
|
|
US9777262B2
(en)
|
2013-03-13 |
2017-10-03 |
President And Fellows Of Harvard College |
Mutants of Cre recombinase
|
|
ES2901396T3
(es)
|
2013-03-14 |
2022-03-22 |
Caribou Biosciences Inc |
Composiciones y métodos de ácidos nucleicos dirigidos a ácido nucleico
|
|
WO2014153118A1
(en)
|
2013-03-14 |
2014-09-25 |
The Board Of Trustees Of The Leland Stanford Junior University |
Treatment of diseases and conditions associated with dysregulation of mammalian target of rapamycin complex 1 (mtorc1)
|
|
US20140283156A1
(en)
|
2013-03-14 |
2014-09-18 |
Cold Spring Harbor Laboratory |
Trans-splicing ribozymes and silent recombinases
|
|
ES2692363T3
(es)
|
2013-03-14 |
2018-12-03 |
Translate Bio, Inc. |
Composiciones terapéuticas de ARNm y su uso para tratar enfermedades y trastornos
|
|
EP2971041B1
(en)
|
2013-03-15 |
2018-11-28 |
The General Hospital Corporation |
Using rna-guided foki nucleases (rfns) to increase specificity for rna-guided genome editing
|
|
US20160046959A1
(en)
|
2013-03-15 |
2016-02-18 |
Carlisle P. Landel |
Reproducible method for testis-mediated genetic modification (tgm) and sperm-mediated genetic modification (sgm)
|
|
BR112015022522B1
(pt)
|
2013-03-15 |
2023-09-26 |
Regents Of The University Of Minnesota |
Método para a modificação do material genômico em uma célula vegetal e vetor viral
|
|
US9234213B2
(en)
|
2013-03-15 |
2016-01-12 |
System Biosciences, Llc |
Compositions and methods directed to CRISPR/Cas genomic engineering systems
|
|
CA3206344A1
(en)
|
2013-03-15 |
2014-09-18 |
Cibus Us Llc |
Methods and compositions for increasing efficiency of targeted gene modification using oligonucleotide-mediated gene repair
|
|
WO2014144094A1
(en)
|
2013-03-15 |
2014-09-18 |
J.R. Simplot Company |
Tal-mediated transfer dna insertion
|
|
US10760064B2
(en)
|
2013-03-15 |
2020-09-01 |
The General Hospital Corporation |
RNA-guided targeting of genetic and epigenomic regulatory proteins to specific genomic loci
|
|
US20140273230A1
(en)
|
2013-03-15 |
2014-09-18 |
Sigma-Aldrich Co., Llc |
Crispr-based genome modification and regulation
|
|
US11332719B2
(en)
|
2013-03-15 |
2022-05-17 |
The Broad Institute, Inc. |
Recombinant virus and preparations thereof
|
|
US20140349400A1
(en)
|
2013-03-15 |
2014-11-27 |
Massachusetts Institute Of Technology |
Programmable Modification of DNA
|
|
HK1218232A1
(zh)
|
2013-03-21 |
2017-02-10 |
桑格摩生物科学股份有限公司 |
使用工程化鋅指蛋白核酸酶靶向斷裂t細胞受體基因
|
|
CA2908403A1
(en)
|
2013-04-02 |
2014-10-09 |
Bayer Cropscience Nv |
Targeted genome engineering in eukaryotes
|
|
ES2831315T3
(es)
|
2013-04-03 |
2021-06-08 |
Memorial Sloan Kettering Cancer Center |
Generación efectiva de células T dirigidas al tumor derivadas de células madre pluripotentes
|
|
EP4286517A3
(en)
|
2013-04-04 |
2024-03-13 |
President and Fellows of Harvard College |
Therapeutic uses of genome editing with crispr/cas systems
|
|
JP6576904B2
(ja)
|
2013-04-04 |
2019-09-18 |
トラスティーズ・オブ・ダートマス・カレッジ |
HIV−1プロウイルスDNAのinvivo切除のための組成物及び方法
|
|
RU2723130C2
(ru)
|
2013-04-05 |
2020-06-08 |
ДАУ АГРОСАЙЕНСИЗ ЭлЭлСи |
Способы и композиции для встраивания экзогенной последовательности в геном растений
|
|
EP2983721B2
(en)
|
2013-04-12 |
2021-01-20 |
Evox Therapeutics Limited |
Therapeutic delivery vesicles
|
|
US20150056629A1
(en)
|
2013-04-14 |
2015-02-26 |
Katriona Guthrie-Honea |
Compositions, systems, and methods for detecting a DNA sequence
|
|
US20160186208A1
(en)
|
2013-04-16 |
2016-06-30 |
Whitehead Institute For Biomedical Research |
Methods of Mutating, Modifying or Modulating Nucleic Acid in a Cell or Nonhuman Mammal
|
|
EP2986709A4
(en)
|
2013-04-16 |
2017-03-15 |
University Of Washington Through Its Center For Commercialization |
Activating an alternative pathway for homology-directed repair to stimulate targeted gene correction and genome engineering
|
|
SI3456831T1
(sl)
|
2013-04-16 |
2021-11-30 |
Regeneron Pharmaceuticals, Inc., |
Ciljna modifikacija podganjega genoma
|
|
WO2014176355A1
(en)
|
2013-04-23 |
2014-10-30 |
President And Fellows Of Harvard College |
In situ interaction determination
|
|
EP2796558A1
(en)
|
2013-04-23 |
2014-10-29 |
Rheinische Friedrich-Wilhelms-Universität Bonn |
Improved gene targeting and nucleic acid carrier molecule, in particular for use in plants
|
|
CN103224947B
(zh)
|
2013-04-28 |
2015-06-10 |
陕西师范大学 |
一种基因打靶系统
|
|
JP6599848B2
(ja)
|
2013-05-10 |
2019-10-30 |
ホワイトヘッド・インスティテュート・フォー・バイオメディカル・リサーチ |
ソルタギング可能なタンパク質を有する赤血球のinvitro生成
|
|
AU2014262867B2
(en)
|
2013-05-10 |
2019-12-05 |
Sangamo Therapeutics, Inc. |
Delivery methods and compositions for nuclease-mediated genome engineering
|
|
AU2014266833B2
(en)
|
2013-05-13 |
2020-07-02 |
Cellectis |
Methods for engineering highly active T cell for immunotherapy
|
|
RS63798B1
(sr)
|
2013-05-13 |
2022-12-30 |
Cellectis |
Cd19 specifični himerni antigenski receptor i njegove primene
|
|
EP3730615A3
(en)
|
2013-05-15 |
2020-12-09 |
Sangamo Therapeutics, Inc. |
Methods and compositions for treatment of a genetic condition
|
|
WO2014186686A2
(en)
|
2013-05-17 |
2014-11-20 |
Two Blades Foundation |
Targeted mutagenesis and genome engineering in plants using rna-guided cas nucleases
|
|
EP3778899A1
(en)
|
2013-05-22 |
2021-02-17 |
Northwestern University |
Rna-directed dna cleavage and gene editing by cas9 enzyme from neisseria meningitidis
|
|
EP3004339B1
(en)
|
2013-05-29 |
2021-07-07 |
Cellectis |
New compact scaffold of cas9 in the type ii crispr system
|
|
AU2014273082B2
(en)
|
2013-05-29 |
2018-11-08 |
Cellectis |
A method for producing precise DNA cleavage using Cas9 nickase activity
|
|
EP3004337B1
(en)
|
2013-05-29 |
2017-08-02 |
Cellectis |
Methods for engineering t cells for immunotherapy by using rna-guided cas nuclease system
|
|
US11414695B2
(en)
|
2013-05-29 |
2022-08-16 |
Agilent Technologies, Inc. |
Nucleic acid enrichment using Cas9
|
|
WO2014194190A1
(en)
|
2013-05-30 |
2014-12-04 |
The Penn State Research Foundation |
Gene targeting and genetic modification of plants via rna-guided genome editing
|
|
JP6450371B2
(ja)
|
2013-05-31 |
2019-01-09 |
セレクティスCellectis |
T細胞受容体α遺伝子を開裂するLAGLIDADGホーミングエンドヌクレアーゼおよびその用途
|
|
WO2014191525A1
(en)
|
2013-05-31 |
2014-12-04 |
Cellectis |
A laglidadg homing endonuclease cleaving the c-c chemokine receptor type-5 (ccr5) gene and uses thereof
|
|
US20140359796A1
(en)
|
2013-05-31 |
2014-12-04 |
Recombinetics, Inc. |
Genetically sterile animals
|
|
US9267135B2
(en)
|
2013-06-04 |
2016-02-23 |
President And Fellows Of Harvard College |
RNA-guided transcriptional regulation
|
|
MY197877A
(en)
|
2013-06-04 |
2023-07-22 |
Harvard College |
Rna-guided transcriptional regulation
|
|
CA2914519A1
(en)
|
2013-06-05 |
2014-12-11 |
Duke University |
Rna-guided gene editing and gene regulation
|
|
WO2014201015A2
(en)
|
2013-06-11 |
2014-12-18 |
The Regents Of The University Of California |
Methods and compositions for target dna modification
|
|
US20150315252A1
(en)
|
2013-06-11 |
2015-11-05 |
Clontech Laboratories, Inc. |
Protein enriched microvesicles and methods of making and using the same
|
|
EP3008192B1
(en)
|
2013-06-11 |
2019-07-17 |
Takara Bio USA, Inc. |
Protein enriched microvesicles and methods of making and using the same
|
|
US20160145631A1
(en)
|
2013-06-14 |
2016-05-26 |
Cellectis |
Methods for non-transgenic genome editing in plants
|
|
EP3725885A1
(en)
|
2013-06-17 |
2020-10-21 |
The Broad Institute, Inc. |
Functional genomics using crispr-cas systems, compositions methods, screens and applications thereof
|
|
EP3011030B1
(en)
|
2013-06-17 |
2023-11-08 |
The Broad Institute, Inc. |
Optimized crispr-cas double nickase systems, methods and compositions for sequence manipulation
|
|
EP3825406A1
(en)
|
2013-06-17 |
2021-05-26 |
The Broad Institute Inc. |
Delivery and use of the crispr-cas systems, vectors and compositions for hepatic targeting and therapy
|
|
EP3011035B1
(en)
|
2013-06-17 |
2020-05-13 |
The Broad Institute, Inc. |
Assay for quantitative evaluation of target site cleavage by one or more crispr-cas guide sequences
|
|
WO2014204724A1
(en)
|
2013-06-17 |
2014-12-24 |
The Broad Institute Inc. |
Delivery, engineering and optimization of tandem guide systems, methods and compositions for sequence manipulation
|
|
EP3620524A1
(en)
|
2013-06-17 |
2020-03-11 |
The Broad Institute, Inc. |
Delivery, engineering and optimization of systems, methods and compositions for targeting and modeling diseases and disorders of post mitotic cells
|
|
SG10201710487VA
(en)
|
2013-06-17 |
2018-01-30 |
Broad Inst Inc |
Delivery, Use and Therapeutic Applications of the Crispr-Cas Systems and Compositions for Targeting Disorders and Diseases Using Viral Components
|
|
EP3011011A4
(en)
|
2013-06-19 |
2017-05-31 |
Sigma-Aldrich Co. LLC |
Targeted integration
|
|
US10011850B2
(en)
|
2013-06-21 |
2018-07-03 |
The General Hospital Corporation |
Using RNA-guided FokI Nucleases (RFNs) to increase specificity for RNA-Guided Genome Editing
|
|
WO2014207043A1
(en)
|
2013-06-25 |
2014-12-31 |
Cellectis |
Modified diatoms for biofuel production
|
|
WO2015002780A1
(en)
|
2013-07-01 |
2015-01-08 |
The Board Of Regents Of The University Of Texas System |
Transcription activator-like effector (tale) libraries and methods of synthesis and use
|
|
EP3019595A4
(en)
|
2013-07-09 |
2016-11-30 |
|
THERAPEUTIC USES OF A GENERIC CHANGE WITH CRISPR / CAS SYSTEMS
|
|
CN105518144A
(zh)
|
2013-07-09 |
2016-04-20 |
哈佛大学校长及研究员协会 |
多重rna向导的基因组工程
|
|
JP6443811B2
(ja)
|
2013-07-10 |
2018-12-26 |
エフストック リミテッド ライアビリティ カンパニー |
Mrap2ノックアウト
|
|
RU2748433C2
(ru)
|
2013-07-10 |
2021-05-25 |
Президент Энд Фэллоуз Оф Харвард Коллидж |
ОРТОГОНАЛЬНЫЕ БЕЛКИ Cas9 ДЛЯ РНК-НАПРАВЛЯЕМОЙ РЕГУЛЯЦИИ И РЕДАКТИРОВАНИЯ ГЕНОВ
|
|
SG11201600115SA
(en)
|
2013-07-10 |
2016-02-26 |
Novartis Ag |
Multiple proteases deficient filamentous fungal cells and methods of use thereof
|
|
SMT202100691T1
(it)
|
2013-07-11 |
2022-01-10 |
Modernatx Inc |
Composizioni 5 comprendenti polinucleotidi sintetici che codificano proteine correlate a crispr e sgrna sintetici e metodi d'uso
|
|
US20160264982A1
(en)
|
2013-07-16 |
2016-09-15 |
Shanghai Institutes For Biological Sciences, Chinese Academy Of Sciences |
Method for plant genome site-directed modification
|
|
JP6482546B2
(ja)
|
2013-07-19 |
2019-03-13 |
ラリクス・バイオサイエンス・リミテッド・ライアビリティ・カンパニーLarix Bioscience, Llc |
二重対立遺伝子ノックアウトを生成するための方法および組成物
|
|
GB201313235D0
(en)
|
2013-07-24 |
2013-09-04 |
Univ Edinburgh |
Antiviral Compositions Methods and Animals
|
|
CN103388006B
(zh)
|
2013-07-26 |
2015-10-28 |
华东师范大学 |
一种基因定点突变的构建方法
|
|
US11306328B2
(en)
|
2013-07-26 |
2022-04-19 |
President And Fellows Of Harvard College |
Genome engineering
|
|
US10421957B2
(en)
|
2013-07-29 |
2019-09-24 |
Agilent Technologies, Inc. |
DNA assembly using an RNA-programmable nickase
|
|
US9944925B2
(en)
|
2013-08-02 |
2018-04-17 |
Enevolv, Inc. |
Processes and host cells for genome, pathway, and biomolecular engineering
|
|
ITTO20130669A1
(it)
|
2013-08-05 |
2015-02-06 |
Consiglio Nazionale Ricerche |
Vettore adeno-associato ricombinante muscolo-specifico e suo impiego nel trattamento di patologie muscolari
|
|
US20150044772A1
(en)
|
2013-08-09 |
2015-02-12 |
Sage Labs, Inc. |
Crispr/cas system-based novel fusion protein and its applications in genome editing
|
|
US20150044192A1
(en)
|
2013-08-09 |
2015-02-12 |
President And Fellows Of Harvard College |
Methods for identifying a target site of a cas9 nuclease
|
|
WO2015021990A1
(en)
|
2013-08-16 |
2015-02-19 |
University Of Copenhagen |
Rna probing method and reagents
|
|
WO2015024017A2
(en)
|
2013-08-16 |
2015-02-19 |
President And Fellows Of Harvard College |
Rna polymerase, methods of purification and methods of use
|
|
CN105705640B
(zh)
|
2013-08-20 |
2019-02-15 |
非营利性组织佛兰芒综合大学生物技术研究所 |
抑制lncRNA用于治疗黑素瘤
|
|
US9359599B2
(en)
|
2013-08-22 |
2016-06-07 |
President And Fellows Of Harvard College |
Engineered transcription activator-like effector (TALE) domains and uses thereof
|
|
CA2922089C
(en)
|
2013-08-22 |
2022-07-05 |
E. I. Du Pont De Nemours And Company |
Plant genome modification using guide rna/cas endonuclease systems and methods of use
|
|
GB201315321D0
(en)
|
2013-08-28 |
2013-10-09 |
Koninklijke Nederlandse Akademie Van Wetenschappen |
Transduction Buffer
|
|
AU2014312295C1
(en)
|
2013-08-28 |
2020-08-13 |
Sangamo Therapeutics, Inc. |
Compositions for linking DNA-binding domains and cleavage domains
|
|
BR112016004091A2
(pt)
|
2013-08-29 |
2017-10-17 |
Univ Temple |
métodos e composições para tratamento guiado por rna de infecção por hiv
|
|
CN105682452B
(zh)
|
2013-09-04 |
2018-10-16 |
美国陶氏益农公司 |
用于在作物中确定供体插入的快速靶向分析
|
|
EP3041931B1
(en)
|
2013-09-04 |
2020-06-10 |
Csir |
Site-specific nuclease single-cell assay targeting gene regulatory elements to silence gene expression
|
|
EP3041345B1
(de)
|
2013-09-04 |
2024-05-01 |
KWS SAAT SE & Co. KGaA |
Helminthosporium turcicum-resistente pflanze
|
|
DK3041498T3
(da)
|
2013-09-05 |
2022-05-09 |
Massachusetts Inst Technology |
Afstemning af mikrobielle populationer med programmerbare nukleaser
|
|
US9322037B2
(en)
|
2013-09-06 |
2016-04-26 |
President And Fellows Of Harvard College |
Cas9-FokI fusion proteins and uses thereof
|
|
US9228207B2
(en)
|
2013-09-06 |
2016-01-05 |
President And Fellows Of Harvard College |
Switchable gRNAs comprising aptamers
|
|
US9737604B2
(en)
|
2013-09-06 |
2017-08-22 |
President And Fellows Of Harvard College |
Use of cationic lipids to deliver CAS9
|
|
EP3988649B1
(en)
|
2013-09-18 |
2024-11-27 |
Kymab Limited |
Methods, cells and organisms
|
|
WO2015040075A1
(en)
|
2013-09-18 |
2015-03-26 |
Genome Research Limited |
Genomic screening methods using rna-guided endonucleases
|
|
WO2015042393A2
(en)
|
2013-09-20 |
2015-03-26 |
President And Fellows Of Harvard College |
Evolved sortases and uses thereof
|
|
RU2670512C2
(ru)
|
2013-09-23 |
2018-10-23 |
Ренссилэйер Политекник Инститьют |
Доставка генов, опосредованная наночастицами, геномная коррекция и лиганд-направленная модификация в различных клеточных популяциях
|
|
WO2015048690A1
(en)
|
2013-09-27 |
2015-04-02 |
The Regents Of The University Of California |
Optimized small guide rnas and methods of use
|
|
US20160237455A1
(en)
|
2013-09-27 |
2016-08-18 |
Editas Medicine, Inc. |
Crispr-related methods and compositions
|
|
US20160237451A1
(en)
|
2013-09-30 |
2016-08-18 |
Regents Of The University Of Minnesota |
Conferring resistance to geminiviruses in plants using crispr/cas systems
|
|
AU2014324408A1
(en)
|
2013-09-30 |
2016-04-07 |
The Regents Of The University Of California |
Identification of CXCR8, a novel chemokine receptor
|
|
US20160208214A1
(en)
|
2013-10-02 |
2016-07-21 |
Northeastern University |
Methods and compositions for generation of developmentally-incompetent eggs in recipients of nuclear genetic transfer
|
|
JP5774657B2
(ja)
|
2013-10-04 |
2015-09-09 |
国立大学法人京都大学 |
エレクトロポレーションを利用した哺乳類の遺伝子改変方法
|
|
US20160237402A1
(en)
|
2013-10-07 |
2016-08-18 |
Northeastern University |
Methods and Compositions for Ex Vivo Generation of Developmentally Competent Eggs from Germ Line Cells Using Autologous Cell Systems
|
|
WO2015052231A2
(en)
|
2013-10-08 |
2015-04-16 |
Technical University Of Denmark |
Multiplex editing system
|
|
DE102013111099B4
(de)
|
2013-10-08 |
2023-11-30 |
Eberhard Karls Universität Tübingen Medizinische Fakultät |
Permanente Genkorrektur mittels nukleotidmodifizierter messenger RNA
|
|
JP2015076485A
(ja)
|
2013-10-08 |
2015-04-20 |
株式会社ジャパンディスプレイ |
表示装置
|
|
US20150098954A1
(en)
|
2013-10-08 |
2015-04-09 |
Elwha Llc |
Compositions and Methods Related to CRISPR Targeting
|
|
AU2014333776B2
(en)
|
2013-10-11 |
2021-01-28 |
Cellectis |
Methods and kits for detecting nucleic acid sequences of interest using DNA-binding protein domain
|
|
WO2015057671A1
(en)
|
2013-10-14 |
2015-04-23 |
The Broad Institute, Inc. |
Artificial transcription factors comprising a sliding domain and uses thereof
|
|
WO2015057852A1
(en)
|
2013-10-15 |
2015-04-23 |
The California Institute For Biomedical Research |
Chimeric antigen receptor t cell switches and uses thereof
|
|
AU2014337367B2
(en)
|
2013-10-15 |
2020-04-30 |
The Scripps Research Institute |
Peptidic chimeric antigen receptor T cell switches and uses thereof
|
|
WO2015057976A1
(en)
|
2013-10-17 |
2015-04-23 |
Sangamo Biosciences, Inc. |
Delivery methods and compositions for nuclease-mediated genome engineering in hematopoietic stem cells
|
|
AU2014337248B2
(en)
|
2013-10-17 |
2020-09-24 |
Sangamo Therapeutics, Inc. |
Delivery methods and compositions for nuclease-mediated genome engineering
|
|
WO2015058047A2
(en)
|
2013-10-18 |
2015-04-23 |
President And Fellows Of Harvard College |
Fluorination of organic compounds
|
|
WO2015059265A1
(en)
|
2013-10-25 |
2015-04-30 |
Cellectis |
Design of rare-cutting endonucleases for efficient and specific targeting dna sequences comprising highly repetitive motives
|
|
WO2015065964A1
(en)
|
2013-10-28 |
2015-05-07 |
The Broad Institute Inc. |
Functional genomics using crispr-cas systems, compositions, methods, screens and applications thereof
|
|
US10584358B2
(en)
|
2013-10-30 |
2020-03-10 |
North Carolina State University |
Compositions and methods related to a type-II CRISPR-Cas system in Lactobacillus buchneri
|
|
EP3065540B1
(en)
|
2013-11-04 |
2021-12-15 |
Corteva Agriscience LLC |
Optimal maize loci
|
|
US10077449B2
(en)
|
2013-11-04 |
2018-09-18 |
Dow Agrosciences Llc |
Universal donor system for gene targeting
|
|
UA121459C2
(uk)
|
2013-11-04 |
2020-06-10 |
Дау Агросаєнсиз Елелсі |
Рекомбінантна молекула нуклеїнової кислоти для трансформації рослини сої
|
|
AP2016009227A0
(en)
|
2013-11-04 |
2016-05-31 |
Dow Agrosciences Llc |
Optimal maize loci
|
|
MX362066B
(es)
|
2013-11-04 |
2019-01-07 |
Dow Agrosciences Llc |
Loci óptimos de soya.
|
|
US10752906B2
(en)
|
2013-11-05 |
2020-08-25 |
President And Fellows Of Harvard College |
Precise microbiota engineering at the cellular level
|
|
KR102523466B1
(ko)
|
2013-11-07 |
2023-04-20 |
에디타스 메디신, 인코포레이티드 |
지배적인 gRNA를 이용하는 CRISPR-관련 방법 및 조성물
|
|
WO2015077058A2
(en)
|
2013-11-08 |
2015-05-28 |
The Broad Institute, Inc. |
Compositions and methods for selecting a treatment for b-cell neoplasias
|
|
US20150132263A1
(en)
|
2013-11-11 |
2015-05-14 |
Radiant Genomics, Inc. |
Compositions and methods for targeted gene disruption in prokaryotes
|
|
MX391904B
(es)
|
2013-11-11 |
2025-03-12 |
Sangamo Biosciences Inc |
Un represor genetico para usarse en el tratamiento de la enfermedad de huntington.
|
|
EP3492593B1
(en)
|
2013-11-13 |
2021-08-18 |
Children's Medical Center Corporation |
Nuclease-mediated regulation of gene expression
|
|
US9951353B2
(en)
|
2013-11-15 |
2018-04-24 |
The United States Of America, As Represented By The Secretary, Dept. Of Health And Human Services |
Engineering neural stem cells using homologous recombination
|
|
US20160298096A1
(en)
|
2013-11-18 |
2016-10-13 |
Crispr Therapeutics Ag |
Crispr-cas system materials and methods
|
|
JP2016538342A
(ja)
|
2013-11-18 |
2016-12-08 |
イエール ユニバーシティ |
トランスポゾンを使用する組成物および方法
|
|
WO2015075056A1
(en)
|
2013-11-19 |
2015-05-28 |
Thermo Fisher Scientific Baltics Uab |
Programmable enzymes for isolation of specific dna fragments
|
|
US10787684B2
(en)
|
2013-11-19 |
2020-09-29 |
President And Fellows Of Harvard College |
Large gene excision and insertion
|
|
US9074199B1
(en)
|
2013-11-19 |
2015-07-07 |
President And Fellows Of Harvard College |
Mutant Cas9 proteins
|
|
EP3071592B1
(en)
|
2013-11-20 |
2021-01-06 |
Fondazione Telethon |
Artificial dna-binding proteins and uses thereof
|
|
EP3985118A1
(en)
|
2013-11-22 |
2022-04-20 |
MiNA Therapeutics Limited |
C/ebp alpha short activating rna compositions and methods of use
|
|
AU2014351797B2
(en)
|
2013-11-22 |
2021-03-11 |
Cellectis |
Method of engineering chemotherapy drug resistant T-cells for immunotherapy
|
|
AU2014351871B2
(en)
|
2013-11-22 |
2020-02-13 |
Cellectis |
Method for generating batches of allogeneic T-cells with averaged potency
|
|
CN103642836A
(zh)
|
2013-11-26 |
2014-03-19 |
苏州同善生物科技有限公司 |
一种基于crispr基因敲除技术建立脆性x综合症灵长类动物模型的方法
|
|
CN103614415A
(zh)
|
2013-11-27 |
2014-03-05 |
苏州同善生物科技有限公司 |
一种基于crispr基因敲除技术建立肥胖症大鼠动物模型的方法
|
|
US10557151B2
(en)
|
2013-11-28 |
2020-02-11 |
Horizon Discovery Limited |
Somatic human cell line mutations
|
|
HUE051628T2
(hu)
|
2013-12-09 |
2021-03-01 |
Sangamo Therapeutics Inc |
Eljárások és kompozíciók genom-manipulálására
|
|
US9546384B2
(en)
|
2013-12-11 |
2017-01-17 |
Regeneron Pharmaceuticals, Inc. |
Methods and compositions for the targeted modification of a mouse genome
|
|
WO2015089462A1
(en)
|
2013-12-12 |
2015-06-18 |
The Broad Institute Inc. |
Delivery, use and therapeutic applications of the crispr-cas systems and compositions for genome editing
|
|
JP2017503485A
(ja)
|
2013-12-12 |
2017-02-02 |
ザ・ブロード・インスティテュート・インコーポレイテッド |
遺伝子産物の発現、構造情報、及び誘導性モジュラーcas酵素を変更するためのcrispr−cas系並びに方法
|
|
WO2015089364A1
(en)
|
2013-12-12 |
2015-06-18 |
The Broad Institute Inc. |
Crystal structure of a crispr-cas system, and uses thereof
|
|
KR20160089530A
(ko)
|
2013-12-12 |
2016-07-27 |
더 브로드 인스티튜트, 인코퍼레이티드 |
Hbv 및 바이러스 질병 및 질환을 위한 crisprcas 시스템 및 조성물의 전달,용도 및 치료적 적용
|
|
BR112016013547A2
(pt)
|
2013-12-12 |
2017-10-03 |
Broad Inst Inc |
Composições e métodos de uso de sistemas crispr-cas em distúrbios de repetições de nucleotídeos
|
|
EP3080266B1
(en)
|
2013-12-12 |
2021-02-03 |
The Regents of The University of California |
Methods and compositions for modifying a single stranded target nucleic acid
|
|
EP4219699A1
(en)
|
2013-12-12 |
2023-08-02 |
The Broad Institute, Inc. |
Engineering of systems, methods and optimized guide compositions with new architectures for sequence manipulation
|
|
EP3470089A1
(en)
|
2013-12-12 |
2019-04-17 |
The Broad Institute Inc. |
Delivery, use and therapeutic applications of the crispr-cas systems and compositions for targeting disorders and diseases using particle delivery components
|
|
US20150166982A1
(en)
|
2013-12-12 |
2015-06-18 |
President And Fellows Of Harvard College |
Methods for correcting pi3k point mutations
|
|
EP3080271B1
(en)
|
2013-12-12 |
2020-02-12 |
The Broad Institute, Inc. |
Systems, methods and compositions for sequence manipulation with optimized functional crispr-cas systems
|
|
US20160312233A1
(en)
|
2013-12-13 |
2016-10-27 |
Cellectis |
New method of selection of algal-transformed cells using nuclease
|
|
WO2015086795A1
(en)
|
2013-12-13 |
2015-06-18 |
Cellectis |
Cas9 nuclease platform for microalgae genome engineering
|
|
US20150191744A1
(en)
|
2013-12-17 |
2015-07-09 |
University Of Massachusetts |
Cas9 effector-mediated regulation of transcription, differentiation and gene editing/labeling
|
|
MX2016007797A
(es)
|
2013-12-19 |
2016-09-07 |
Amyris Inc |
Metodos para integracion genomica.
|
|
EP3090044B1
(en)
|
2013-12-26 |
2021-11-03 |
The General Hospital Corporation |
Multiplex guide rnas
|
|
DK3090062T3
(da)
|
2013-12-30 |
2020-09-21 |
Univ Pittsburgh Commonwealth Sys Higher Education |
Fusionsgener associeret med fremadskridende prostatakræft
|
|
CN103668472B
(zh)
|
2013-12-31 |
2014-12-24 |
北京大学 |
利用CRISPR/Cas9系统构建真核基因敲除文库的方法
|
|
WO2015103153A1
(en)
|
2013-12-31 |
2015-07-09 |
The Regents Of The University Of California |
Cas9 crystals and methods of use thereof
|
|
WO2015105928A1
(en)
|
2014-01-08 |
2015-07-16 |
President And Fellows Of Harvard College |
Rna-guided gene drives
|
|
CA2936936A1
(en)
|
2014-01-14 |
2015-07-23 |
Lam Therapeutics, Inc. |
Mutagenesis methods
|
|
US10774338B2
(en)
|
2014-01-16 |
2020-09-15 |
The Regents Of The University Of California |
Generation of heritable chimeric plant traits
|
|
US10179911B2
(en)
|
2014-01-20 |
2019-01-15 |
President And Fellows Of Harvard College |
Negative selection and stringency modulation in continuous evolution systems
|
|
GB201400962D0
(en)
|
2014-01-21 |
2014-03-05 |
Kloehn Peter C |
Screening for target-specific affinity binders using RNA interference
|
|
EP3097194A4
(en)
|
2014-01-21 |
2017-08-23 |
Institute Of Genetics And Developmental Biology, Chinese Academy Of Sciences |
Modified plants
|
|
US9663770B2
(en)
|
2014-01-22 |
2017-05-30 |
Life Technologies Corporation |
Reverse transcriptases for use in high temperature nucleic acid synthesis
|
|
WO2015112896A2
(en)
|
2014-01-24 |
2015-07-30 |
North Carolina State University |
Methods and compositions for sequences guiding cas9 targeting
|
|
WO2015112790A2
(en)
|
2014-01-24 |
2015-07-30 |
Children's Medical Center Corporation |
High-throughput mouse model for optimizing antibody affinities
|
|
US10354746B2
(en)
|
2014-01-27 |
2019-07-16 |
Georgia Tech Research Corporation |
Methods and systems for identifying CRISPR/Cas off-target sites
|
|
CN104805078A
(zh)
|
2014-01-28 |
2015-07-29 |
北京大学 |
用于高效基因组编辑的rna分子的设计、合成及其应用
|
|
WO2015116686A1
(en)
|
2014-01-29 |
2015-08-06 |
Agilent Technologies, Inc. |
Cas9-based isothermal method of detection of specific dna sequence
|
|
WO2015117041A1
(en)
|
2014-01-30 |
2015-08-06 |
Nair Ramesh B |
Gene modification-mediated methods and compositions for generating dominant traits in eukaryotic systems
|
|
WO2015116969A2
(en)
|
2014-01-30 |
2015-08-06 |
The Board Of Trustees Of The University Of Arkansas |
Method, vectors, cells, seeds and kits for stacking genes into a single genomic site
|
|
EP4249036A3
(en)
|
2014-01-31 |
2023-10-25 |
Factor Bioscience Inc. |
Methods and products for nucleic acid production and delivery
|
|
GB201401707D0
(en)
|
2014-01-31 |
2014-03-19 |
Sec Dep For Health The |
Adeno-associated viral vectors
|
|
PL3102673T3
(pl)
|
2014-02-03 |
2020-11-02 |
Sangamo Therapeutics, Inc. |
Sposoby i kompozycje do leczenia talasemii beta
|
|
WO2015115903A1
(en)
|
2014-02-03 |
2015-08-06 |
Academisch Ziekenhuis Leiden H.O.D.N. Lumc |
Site-specific dna break-induced genome editing using engineered nucleases
|
|
CA2938669A1
(en)
|
2014-02-04 |
2015-08-13 |
Igenomx International Genomics Corporation |
Genome fractioning
|
|
WO2015118156A1
(en)
|
2014-02-07 |
2015-08-13 |
Vib Vzw |
Inhibition of neat1 for treatment of solid tumors
|
|
CA3161903C
(en)
|
2014-02-11 |
2025-09-09 |
Univ Colorado Regents |
Crispr enabled multiplexed genome engineering
|
|
EP3105325B2
(en)
|
2014-02-13 |
2024-10-23 |
Takara Bio USA, Inc. |
Methods of depleting a target molecule from an initial collection of nucleic acids, and compositions and kits for practicing the same
|
|
CA2937711C
(en)
|
2014-02-14 |
2020-10-20 |
Cellectis |
Cells for immunotherapy engineered for targeting antigen present both on immune cells and pathological cells
|
|
CN106232823A
(zh)
|
2014-02-18 |
2016-12-14 |
杜克大学 |
灭活病毒复制的组合物及其制备和使用方法
|
|
EP3116994B1
(en)
|
2014-02-20 |
2019-07-24 |
DSM IP Assets B.V. |
Phage-insensitive streptococcus thermophilus
|
|
CA2939711C
(en)
|
2014-02-21 |
2020-09-29 |
Cellectis |
Method for in situ inhibition of regulatory t cells
|
|
WO2015127439A1
(en)
|
2014-02-24 |
2015-08-27 |
Sangamo Biosciences, Inc. |
Methods and compositions for nuclease-mediated targeted integration
|
|
US20170015994A1
(en)
|
2014-02-24 |
2017-01-19 |
Massachusetts Institute Of Technology |
Methods for in vivo genome editing
|
|
US10301636B2
(en)
|
2014-02-25 |
2019-05-28 |
National Research And Development Agency National Agriculture And Food Research Organization |
Plant cell comprising mutation introduced in target DNA, and method for producing the plant cell
|
|
EP3971283A1
(en)
|
2014-02-27 |
2022-03-23 |
Monsanto Technology LLC |
Compositions and methods for site directed genomic modification
|
|
CN103820441B
(zh)
|
2014-03-04 |
2017-05-17 |
黄行许 |
CRISPR‑Cas9特异性敲除人CTLA4基因的方法以及用于特异性靶向CTLA4基因的sgRNA
|
|
CN103820454B
(zh)
|
2014-03-04 |
2016-03-30 |
上海金卫生物技术有限公司 |
CRISPR-Cas9特异性敲除人PD1基因的方法以及用于特异性靶向PD1基因的sgRNA
|
|
WO2015134812A1
(en)
|
2014-03-05 |
2015-09-11 |
Editas Medicine, Inc. |
Crispr/cas-related methods and compositions for treating usher syndrome and retinitis pigmentosa
|
|
CN106459957B
(zh)
|
2014-03-05 |
2020-03-20 |
国立大学法人神户大学 |
用于特异性转变靶向dna序列的核酸碱基的基因组序列的修饰方法、及其使用的分子复合体
|
|
US9938521B2
(en)
|
2014-03-10 |
2018-04-10 |
Editas Medicine, Inc. |
CRISPR/CAS-related methods and compositions for treating leber's congenital amaurosis 10 (LCA10)
|
|
PL3116902T3
(pl)
|
2014-03-11 |
2020-07-27 |
Cellectis |
Sposób wytwarzania limfocytów T kompatybilnych do przeszczepienia alogenicznego
|
|
EP4659765A2
(en)
|
2014-03-12 |
2025-12-10 |
Precision Biosciences, Inc. |
Dystrophin gene exon deletion using engineered nucleases
|
|
WO2015138870A2
(en)
|
2014-03-13 |
2015-09-17 |
The Trustees Of The University Of Pennsylvania |
Compositions and methods for targeted epigenetic modification
|
|
WO2015138878A1
(en)
|
2014-03-13 |
2015-09-17 |
Research Institute At Nationwide Children's Hospital, Inc. |
Methods of delivering heparin binding epidermal growth factor using stem cell generated exosomes
|
|
EP3116305B1
(en)
|
2014-03-14 |
2023-12-06 |
Cibus US LLC |
Methods and compositions for increasing efficiency of targeted gene modification using oligonucleotide-mediated gene repair
|
|
WO2015138855A1
(en)
|
2014-03-14 |
2015-09-17 |
The Regents Of The University Of California |
Vectors and methods for fungal genome engineering by crispr-cas9
|
|
EP3929279A1
(en)
|
2014-03-18 |
2021-12-29 |
Sangamo Therapeutics, Inc. |
Methods and compositions for regulation of zinc finger protein expression
|
|
AU2015234204A1
(en)
|
2014-03-20 |
2016-10-06 |
Universite Laval |
CRISPR-based methods and products for increasing frataxin levels and uses thereof
|
|
MX392639B
(es)
|
2014-03-21 |
2025-03-24 |
Univ Leland Stanford Junior |
Vectores virales recombinantes para la integración de transgenes
|
|
CN112964883A
(zh)
|
2014-03-24 |
2021-06-15 |
艾摩科诊断公司 |
用于全身性和非全身性自身免疫紊乱的改进的抗核抗体检测和诊断
|
|
SI3122878T1
(sl)
|
2014-03-24 |
2019-05-31 |
Translate Bio, Inc. |
MRNA terapija za zdravljenje očesnih bolezni
|
|
EP3129484A1
(en)
|
2014-03-25 |
2017-02-15 |
Editas Medicine, Inc. |
Crispr/cas-related methods and compositions for treating hiv infection and aids
|
|
EP3122870B1
(en)
|
2014-03-25 |
2022-06-29 |
Ginkgo Bioworks Inc. |
Methods and genetic systems for cell engineering
|
|
US11242525B2
(en)
|
2014-03-26 |
2022-02-08 |
Editas Medicine, Inc. |
CRISPR/CAS-related methods and compositions for treating sickle cell disease
|
|
US9609415B2
(en)
|
2014-03-26 |
2017-03-28 |
Bose Corporation |
Headphones with cable management
|
|
WO2015148860A1
(en)
|
2014-03-26 |
2015-10-01 |
Editas Medicine, Inc. |
Crispr/cas-related methods and compositions for treating beta-thalassemia
|
|
EP3122877B1
(en)
|
2014-03-26 |
2023-03-22 |
University of Maryland, College Park |
Targeted genome editing in zygotes of domestic large animals
|
|
US9993563B2
(en)
|
2014-03-28 |
2018-06-12 |
Aposense Ltd. |
Compounds and methods for trans-membrane delivery of molecules
|
|
AU2015237746B2
(en)
|
2014-03-28 |
2020-01-30 |
Aposense Ltd. |
Compounds and methods for trans-membrane delivery of molecules
|
|
EP3126497B1
(en)
|
2014-04-01 |
2018-12-12 |
Editas Medicine, Inc. |
Crispr/cas-related methods and compositions for treating herpes simplex virus type 1 (hsv-1)
|
|
WO2015153791A1
(en)
|
2014-04-01 |
2015-10-08 |
Editas Medicine, Inc. |
Crispr/cas-related methods and compositions for treating herpes simplex virus type 2 (hsv-2)
|
|
WO2015153760A2
(en)
|
2014-04-01 |
2015-10-08 |
Sangamo Biosciences, Inc. |
Methods and compositions for prevention or treatment of a nervous system disorder
|
|
EP3540061A1
(en)
|
2014-04-02 |
2019-09-18 |
Editas Medicine, Inc. |
Crispr/cas-related methods and compositions for treating primary open angle glaucoma
|
|
WO2015153889A2
(en)
|
2014-04-02 |
2015-10-08 |
University Of Florida Research Foundation, Incorporated |
Materials and methods for the treatment of latent viral infection
|
|
CN103911376B
(zh)
|
2014-04-03 |
2017-02-15 |
黄行许 |
CRISPR‑Cas9靶向敲除乙肝病毒cccDNA及其特异性sgRNA
|
|
CN106170550A
(zh)
|
2014-04-03 |
2016-11-30 |
麻省理工学院 |
用于产生导引rna的方法和组合物
|
|
US11439712B2
(en)
|
2014-04-08 |
2022-09-13 |
North Carolina State University |
Methods and compositions for RNA-directed repression of transcription using CRISPR-associated genes
|
|
WO2015157070A2
(en)
|
2014-04-09 |
2015-10-15 |
Editas Medicine, Inc. |
Crispr/cas-related methods and compositions for treating cystic fibrosis
|
|
EP3129488B1
(en)
|
2014-04-10 |
2019-06-12 |
The Regents of The University of California |
Methods and compositions for using argonaute to modify a single stranded target nucleic acid
|
|
EP3129473B8
(en)
|
2014-04-11 |
2020-12-23 |
Cellectis |
Method for generating immune cells resistant to arginine and/or tryptophan depleted microenvironment
|
|
US20170029805A1
(en)
|
2014-04-14 |
2017-02-02 |
Maxcyte, Inc. |
Methods and compositions for modifying genomic dna
|
|
CN103923911B
(zh)
|
2014-04-14 |
2016-06-08 |
上海金卫生物技术有限公司 |
CRISPR-Cas9特异性敲除人CCR5基因的方法以及用于特异性靶向CCR5基因的sgRNA
|
|
ES2827279T3
(es)
|
2014-04-14 |
2021-05-20 |
Nemesis Bioscience Ltd |
Terapéutico
|
|
GB201406968D0
(en)
|
2014-04-17 |
2014-06-04 |
Green Biologics Ltd |
Deletion mutants
|
|
GB201406970D0
(en)
|
2014-04-17 |
2014-06-04 |
Green Biologics Ltd |
Targeted mutations
|
|
EP3800248A3
(en)
|
2014-04-18 |
2021-08-04 |
Editas Medicine, Inc. |
Crispr-cas-related methods, compositions and components for cancer immunotherapy
|
|
CN105039399A
(zh)
|
2014-04-23 |
2015-11-11 |
复旦大学 |
多能干细胞-遗传性心肌病心肌细胞及其制备方法
|
|
US9522936B2
(en)
|
2014-04-24 |
2016-12-20 |
Sangamo Biosciences, Inc. |
Engineered transcription activator like effector (TALE) proteins
|
|
KR101823661B1
(ko)
|
2014-04-24 |
2018-01-30 |
기초과학연구원 |
마이크로 상동 기반의 유전자 녹아웃을 위한 뉴클레아제 표적 서열을 확인하는 방법
|
|
JP6933898B2
(ja)
|
2014-04-24 |
2021-09-08 |
ボード オブ リージェンツ, ザ ユニバーシティ オブ テキサス システムBoard Of Regents, The University Of Texas System |
養子細胞治療製品を製造するための誘導多能性幹細胞の適用
|
|
AR100216A1
(es)
|
2014-04-28 |
2016-09-21 |
Recombinetics Inc |
Edición de genes multiplexados
|
|
WO2015168158A1
(en)
|
2014-04-28 |
2015-11-05 |
Fredy Altpeter |
Targeted genome editing to modify lignin biosynthesis and cell wall composition
|
|
RU2016143352A
(ru)
|
2014-04-28 |
2018-05-28 |
ДАУ АГРОСАЙЕНСИЗ ЭлЭлСи |
Трансформация гаплоидной кукурузы
|
|
GB2540694A
(en)
|
2014-04-29 |
2017-01-25 |
Seattle Children's Hospital (Dba Seattle Children's Res Institute) |
CCR5 disruption of cells expressing anti-hiv chimeric antigen receptor (CAR) derived from broadly neutralizing antibodies
|
|
WO2015168404A1
(en)
|
2014-04-30 |
2015-11-05 |
Massachusetts Institute Of Technology |
Toehold-gated guide rna for programmable cas9 circuitry with rna input
|
|
CN104178506B
(zh)
|
2014-04-30 |
2017-03-01 |
清华大学 |
Taler蛋白通过空间位阻发挥转录抑制作用及其应用
|
|
EP3636765A1
(en)
|
2014-04-30 |
2020-04-15 |
Tsinghua University |
Use of tale transcriptional repressor for modulator construction of synthetic gene line in mammalian cells
|
|
WO2015165276A1
(zh)
|
2014-04-30 |
2015-11-05 |
清华大学 |
利用tale转录抑制子在哺乳动物细胞中模块化构建合成基因线路的试剂盒
|
|
WO2015168547A2
(en)
|
2014-05-01 |
2015-11-05 |
Andre Lieber |
In vivo gene engineering with adenoviral vectors
|
|
GB201407852D0
(en)
|
2014-05-02 |
2014-06-18 |
Iontas Ltd |
Preparation of libraries od protein variants expressed in eukaryotic cells and use for selecting binding molecules
|
|
WO2015171603A1
(en)
|
2014-05-06 |
2015-11-12 |
Two Blades Foundation |
Methods for producing plants with enhanced resistance to oomycete pathogens
|
|
CN106413760B
(zh)
|
2014-05-08 |
2020-01-14 |
桑格摩生物科学股份有限公司 |
用于治疗亨廷顿病的方法和组合物
|
|
US10487336B2
(en)
|
2014-05-09 |
2019-11-26 |
The Regents Of The University Of California |
Methods for selecting plants after genome editing
|
|
WO2015172128A1
(en)
|
2014-05-09 |
2015-11-12 |
Indiana University Research And Technology Corporation |
Methods and compositions for treating hepatitis b virus infections
|
|
CA2948429A1
(en)
|
2014-05-09 |
2015-11-12 |
Universite Laval |
Prevention and treatment of alzheimer's disease by genome editing using the crispr/cas system
|
|
WO2015175642A2
(en)
|
2014-05-13 |
2015-11-19 |
Sangamo Biosciences, Inc. |
Methods and compositions for prevention or treatment of a disease
|
|
CN103981212B
(zh)
|
2014-05-16 |
2016-06-01 |
安徽省农业科学院水稻研究所 |
将黄色颖壳的水稻品种的颖壳颜色改为褐色的育种方法
|
|
CN104004782B
(zh)
|
2014-05-16 |
2016-06-08 |
安徽省农业科学院水稻研究所 |
一种延长水稻生育期的育种方法
|
|
EP3142706A1
(en)
|
2014-05-16 |
2017-03-22 |
Vrije Universiteit Brussel |
Genetic correction of myotonic dystrophy type 1
|
|
CN104017821B
(zh)
|
2014-05-16 |
2016-07-06 |
安徽省农业科学院水稻研究所 |
定向编辑颖壳颜色决定基因OsCHI创制褐壳水稻材料的方法
|
|
CN103981211B
(zh)
|
2014-05-16 |
2016-07-06 |
安徽省农业科学院水稻研究所 |
一种创制闭颖授粉水稻材料的育种方法
|
|
WO2015179540A1
(en)
|
2014-05-20 |
2015-11-26 |
Regents Of The University Of Minnesota |
Method for editing a genetic sequence
|
|
CA2852593A1
(en)
|
2014-05-23 |
2015-11-23 |
Universite Laval |
Methods for producing dopaminergic neurons and uses thereof
|
|
US10653123B2
(en)
|
2014-05-27 |
2020-05-19 |
Dana-Farber Cancer Institute, Inc. |
Methods and compositions for perturbing gene expression in hematopoietic stem cell lineages in vivo
|
|
WO2015183026A1
(ko)
|
2014-05-28 |
2015-12-03 |
주식회사 툴젠 |
불활성화된 표적 특이적 뉴클레아제를 이용한 표적 dna의 분리 방법
|
|
JP2017518075A
(ja)
|
2014-05-30 |
2017-07-06 |
ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティー |
潜伏性ウイルス感染を処置するための組成物および方法
|
|
WO2015188056A1
(en)
|
2014-06-05 |
2015-12-10 |
Sangamo Biosciences, Inc. |
Methods and compositions for nuclease design
|
|
HUE049776T2
(hu)
|
2014-06-06 |
2020-10-28 |
Regeneron Pharma |
Módszerek és készítmények egy célzott lókusz módosítására
|
|
CN104004778B
(zh)
|
2014-06-06 |
2016-03-02 |
重庆高圣生物医药有限责任公司 |
含有CRISPR/Cas9系统的靶向敲除载体及其腺病毒和应用
|
|
WO2015188094A1
(en)
|
2014-06-06 |
2015-12-10 |
President And Fellows Of Harvard College |
Methods for targeted modification of genomic dna
|
|
EP3152238A4
(en)
|
2014-06-06 |
2018-01-03 |
The California Institute for Biomedical Research |
Methods of constructing amino terminal immunoglobulin fusion proteins and compositions thereof
|
|
WO2015188135A1
(en)
|
2014-06-06 |
2015-12-10 |
The California Institute For Biomedical Research |
Constant region antibody fusion proteins and compositions thereof
|
|
US11030531B2
(en)
|
2014-06-06 |
2021-06-08 |
Trustees Of Boston University |
DNA recombinase circuits for logical control of gene expression
|
|
US11274302B2
(en)
|
2016-08-17 |
2022-03-15 |
Diacarta Ltd |
Specific synthetic chimeric Xenonucleic acid guide RNA; s(XNA-gRNA) for enhancing CRISPR mediated genome editing efficiency
|
|
EP3155116A4
(en)
|
2014-06-10 |
2017-12-27 |
Massachusetts Institute Of Technology |
Method for gene editing
|
|
CA2951882A1
(en)
|
2014-06-11 |
2015-12-17 |
Tom E. HOWARD |
Factor viii mutation repair and tolerance induction and related cdnas, compositions, methods and systems
|
|
HUE061007T2
(hu)
|
2014-06-11 |
2023-05-28 |
Univ Duke |
Gyors és dinamikus áramlásszabályozásra szolgáló összetételek és módszerek szintetikus matabolikus szelepek segítségével
|
|
WO2015189693A1
(en)
|
2014-06-12 |
2015-12-17 |
King Abdullah University Of Science And Technology |
Targeted viral-mediated plant genome editing using crispr/cas9
|
|
WO2015191911A2
(en)
|
2014-06-12 |
2015-12-17 |
Clontech Laboratories, Inc. |
Protein enriched microvesicles and methods of making and using the same
|
|
JP6930834B2
(ja)
|
2014-06-16 |
2021-09-01 |
ザ・ジョンズ・ホプキンス・ユニバーシティー |
H1プロモーターを用いるcrisprガイドrnaの発現のための組成物および方法
|
|
WO2015195547A1
(en)
|
2014-06-16 |
2015-12-23 |
University Of Washington |
Methods for controlling stem cell potential and for gene editing in stem cells
|
|
JP2017518082A
(ja)
|
2014-06-17 |
2017-07-06 |
ポセイダ セラピューティクス, インコーポレイテッド |
ゲノム中の特異的遺伝子座にタンパク質を指向させるための方法およびその使用
|
|
WO2015193858A1
(en)
|
2014-06-20 |
2015-12-23 |
Cellectis |
Potatoes with reduced granule-bound starch synthase
|
|
IL286474B2
(en)
|
2014-06-23 |
2023-11-01 |
Massachusetts Gen Hospital |
Genome-wide random identification of DSBS assessed by sequencing (guide-sequence)
|
|
PT3354732T
(pt)
|
2014-06-23 |
2020-04-02 |
Regeneron Pharma |
Montagem de dna mediada por nuclease
|
|
WO2015200555A2
(en)
|
2014-06-25 |
2015-12-30 |
Caribou Biosciences, Inc. |
Rna modification to engineer cas9 activity
|
|
GB201411344D0
(en)
|
2014-06-26 |
2014-08-13 |
Univ Leicester |
Cloning
|
|
KR102386101B1
(ko)
|
2014-06-26 |
2022-04-14 |
리제너론 파마슈티칼스 인코포레이티드 |
표적화된 유전자 변형을 위한 방법 및 그 조성물, 및 사용 방법
|
|
EP3162328B1
(en)
|
2014-06-30 |
2022-01-19 |
Kao Corporation |
Adhesive sheet for cooling
|
|
US20170152787A1
(en)
|
2014-06-30 |
2017-06-01 |
Nissan Motor Co., Ltd. |
Internal combustion engine
|
|
WO2016004010A1
(en)
|
2014-07-01 |
2016-01-07 |
Board Of Regents, The University Of Texas System |
Regulated gene expression from viral vectors
|
|
WO2016004318A1
(en)
|
2014-07-02 |
2016-01-07 |
Shire Human Genetic Therapies, Inc. |
Encapsulation of messenger rna
|
|
WO2016007604A1
(en)
|
2014-07-09 |
2016-01-14 |
Gen9, Inc. |
Compositions and methods for site-directed dna nicking and cleaving
|
|
EP2966170A1
(en)
|
2014-07-10 |
2016-01-13 |
Heinrich-Pette-Institut Leibniz-Institut für experimentelle Virologie-Stiftung bürgerlichen Rechts - |
HBV inactivation
|
|
CA2954626A1
(en)
|
2014-07-11 |
2016-01-14 |
E. I. Du Pont De Nemours And Company |
Compositions and methods for producing plants resistant to glyphosate herbicide
|
|
BR112017000621B1
(pt)
|
2014-07-11 |
2024-03-12 |
Pioneer Hi-Bred International, Inc |
Método para melhorar um traço agronômico de uma planta de milho ou de soja
|
|
US11254933B2
(en)
|
2014-07-14 |
2022-02-22 |
The Regents Of The University Of California |
CRISPR/Cas transcriptional modulation
|
|
CN104109687A
(zh)
|
2014-07-14 |
2014-10-22 |
四川大学 |
运动发酵单胞菌CRISPR-Cas9系统的构建与应用
|
|
MX2017000646A
(es)
|
2014-07-15 |
2017-04-27 |
Juno Therapeutics Inc |
Celulas geneticamente modificadas para terapia celular adoptiva.
|
|
WO2016011428A1
(en)
|
2014-07-17 |
2016-01-21 |
University Of Pittsburgh - Of The Commonwealth System Of Higher Education |
Methods of treating cells containing fusion genes
|
|
US9944933B2
(en)
|
2014-07-17 |
2018-04-17 |
Georgia Tech Research Corporation |
Aptamer-guided gene targeting
|
|
US20160053304A1
(en)
|
2014-07-18 |
2016-02-25 |
Whitehead Institute For Biomedical Research |
Methods Of Depleting Target Sequences Using CRISPR
|
|
US10975406B2
(en)
|
2014-07-18 |
2021-04-13 |
Massachusetts Institute Of Technology |
Directed endonucleases for repeatable nucleic acid cleavage
|
|
US20160053272A1
(en)
|
2014-07-18 |
2016-02-25 |
Whitehead Institute For Biomedical Research |
Methods Of Modifying A Sequence Using CRISPR
|
|
AU2015294354B2
(en)
|
2014-07-21 |
2021-10-28 |
Illumina, Inc. |
Polynucleotide enrichment using CRISPR-Cas systems
|
|
RU2751660C2
(ru)
|
2014-07-21 |
2021-07-15 |
Новартис Аг |
Лечение злокачественного новообразования с использованием гуманизированного химерного антигенного рецептора против всма
|
|
US10210987B2
(en)
|
2014-07-22 |
2019-02-19 |
Panasonic Intellectual Property Management Co., Ltd. |
Composite magnetic material, coil component using same, and composite magnetic material manufacturing method
|
|
EP3172315B1
(en)
|
2014-07-24 |
2020-09-30 |
DSM IP Assets B.V. |
Phage resistant lactic acid bacteria
|
|
US9757420B2
(en)
|
2014-07-25 |
2017-09-12 |
Sangamo Therapeutics, Inc. |
Gene editing for HIV gene therapy
|
|
WO2016014794A1
(en)
|
2014-07-25 |
2016-01-28 |
Sangamo Biosciences, Inc. |
Methods and compositions for modulating nuclease-mediated genome engineering in hematopoietic stem cells
|
|
WO2016012544A2
(en)
|
2014-07-25 |
2016-01-28 |
Boehringer Ingelheim International Gmbh |
Enhanced reprogramming to ips cells
|
|
WO2016016119A1
(en)
|
2014-07-26 |
2016-02-04 |
Consiglio Nazionale Delle Ricerche |
Compositions and methods for treatment of muscular dystrophy
|
|
FR3024464A1
(fr)
|
2014-07-30 |
2016-02-05 |
Centre Nat Rech Scient |
Ciblage de vecteurs integratifs non-viraux dans les sequences d'adn nucleolaires chez les eucaryotes
|
|
WO2016019144A2
(en)
|
2014-07-30 |
2016-02-04 |
Sangamo Biosciences, Inc. |
Gene correction of scid-related genes in hematopoietic stem and progenitor cells
|
|
US10077453B2
(en)
|
2014-07-30 |
2018-09-18 |
President And Fellows Of Harvard College |
CAS9 proteins including ligand-dependent inteins
|
|
US9850521B2
(en)
|
2014-08-01 |
2017-12-26 |
Agilent Technologies, Inc. |
In vitro assay buffer for Cas9
|
|
US20160076093A1
(en)
|
2014-08-04 |
2016-03-17 |
University Of Washington |
Multiplex homology-directed repair
|
|
EP2982758A1
(en)
|
2014-08-04 |
2016-02-10 |
Centre Hospitalier Universitaire Vaudois (CHUV) |
Genome editing for the treatment of huntington's disease
|
|
JP6715419B2
(ja)
|
2014-08-06 |
2020-07-01 |
トゥールジェン インコーポレイテッド |
カンピロバクター・ジェジュニcrispr/casシステムに由来するrgenを使用したゲノム編集
|
|
JP6598860B2
(ja)
|
2014-08-06 |
2019-10-30 |
カレッジ オブ メディシン ポチョン チャ ユニバーシティ インダストリー−アカデミック コーオペレイション ファウンデーション |
Hlaをコードする遺伝子のヌクレアーゼ媒介編集により作製される免疫適合性細胞
|
|
WO2016022866A1
(en)
|
2014-08-07 |
2016-02-11 |
Agilent Technologies, Inc. |
Cis-blocked guide rna
|
|
WO2016022931A1
(en)
|
2014-08-07 |
2016-02-11 |
The Rockefeller University |
Compositions and methods for transcription-based crispr-cas dna editing
|
|
JP6837429B2
(ja)
|
2014-08-11 |
2021-03-03 |
ザ ボード オブ リージェンツ オブ ザ ユニバーシティー オブ テキサス システム |
Crispr/cas9媒介遺伝子編集による筋ジストロフィーの予防
|
|
US10513711B2
(en)
|
2014-08-13 |
2019-12-24 |
Dupont Us Holding, Llc |
Genetic targeting in non-conventional yeast using an RNA-guided endonuclease
|
|
US11071289B2
(en)
|
2014-08-14 |
2021-07-27 |
Biocytogen Boston Corp |
DNA knock-in system
|
|
CN104178461B
(zh)
|
2014-08-14 |
2017-02-01 |
北京蛋白质组研究中心 |
携带cas9的重组腺病毒及其应用
|
|
US9879270B2
(en)
|
2014-08-15 |
2018-01-30 |
Wisconsin Alumni Research Foundation |
Constructs and methods for genome editing and genetic engineering of fungi and protists
|
|
DK3180426T3
(da)
|
2014-08-17 |
2020-03-30 |
Broad Inst Inc |
Genomredigering ved anvendelse af cas9-nickaser
|
|
JP6806668B2
(ja)
|
2014-08-19 |
2021-01-06 |
プレジデント アンド フェローズ オブ ハーバード カレッジ |
核酸をプロービングおよびマッピングするためのrna誘導型システム
|
|
WO2016028887A1
(en)
|
2014-08-19 |
2016-02-25 |
Pacific Biosciences Of California, Inc. |
Compositions and methods for enrichment of nucleic acids
|
|
US20190045758A1
(en)
|
2014-08-20 |
2019-02-14 |
Shanghai Institutes For Biological Sciences, Chinese Academy Of Sciences |
Biomarker and Therapeutic Target for Triple Negative Breast Cancer
|
|
JP2017525377A
(ja)
|
2014-08-25 |
2017-09-07 |
ジーンウィーブ バイオサイエンシズ,インコーポレイティド |
非複製的形質導入粒子及び形質導入粒子に基づくレポーターシステム
|
|
WO2016033230A1
(en)
|
2014-08-26 |
2016-03-03 |
The Regents Of The University Of California |
Hypersensitive aba receptors
|
|
ES2730378T3
(es)
|
2014-08-27 |
2019-11-11 |
Caribou Biosciences Inc |
Procedimientos para incrementar la eficiencia de la modificación mediada por Cas9
|
|
WO2016033298A1
(en)
|
2014-08-28 |
2016-03-03 |
North Carolina State University |
Novel cas9 proteins and guiding features for dna targeting and genome editing
|
|
US10570418B2
(en)
|
2014-09-02 |
2020-02-25 |
The Regents Of The University Of California |
Methods and compositions for RNA-directed target DNA modification
|
|
KR20160029247A
(ko)
|
2014-09-05 |
2016-03-15 |
한국외국어대학교 연구산학협력단 |
신규한 융합체 및 이의 제조 방법
|
|
EP3188746B1
(en)
|
2014-09-05 |
2024-06-19 |
The Johns Hopkins University |
Targeting capn9 activity as a therapeutic strategy for the treatment of myofibroblast differentiation and associated pathologies
|
|
DK3189140T3
(en)
|
2014-09-05 |
2020-02-03 |
Univ Vilnius |
Programmerbar RNA-fragmentering ved hjælp af TYPE III-A CRISPR-Cas-systemet af Streptococcus thermophilus
|
|
WO2016040594A1
(en)
|
2014-09-10 |
2016-03-17 |
The Regents Of The University Of California |
Reconstruction of ancestral cells by enzymatic recording
|
|
WO2016040030A1
(en)
|
2014-09-12 |
2016-03-17 |
E. I. Du Pont De Nemours And Company |
Generation of site-specific-integration sites for complex trait loci in corn and soybean, and methods of use
|
|
AU2015318061B2
(en)
|
2014-09-16 |
2018-05-17 |
Gilead Sciences, Inc. |
Solid forms of a toll-like receptor modulator
|
|
HUE055583T2
(hu)
|
2014-09-16 |
2021-12-28 |
Sangamo Therapeutics Inc |
Eljárások és készítmények nukleáz által közvetített genommódosításhoz és -javításhoz hematopoetikus õssejtekben
|
|
WO2016049024A2
(en)
|
2014-09-24 |
2016-03-31 |
The Broad Institute Inc. |
Delivery, use and therapeutic applications of the crispr-cas systems and compositions for modeling competition of multiple cancer mutations in vivo
|
|
WO2016049163A2
(en)
|
2014-09-24 |
2016-03-31 |
The Broad Institute Inc. |
Use and production of chd8+/- transgenic animals with behavioral phenotypes characteristic of autism spectrum disorder
|
|
WO2016049251A1
(en)
|
2014-09-24 |
2016-03-31 |
The Broad Institute Inc. |
Delivery, use and therapeutic applications of the crispr-cas systems and compositions for modeling mutations in leukocytes
|
|
CA2961555A1
(en)
|
2014-09-24 |
2016-03-31 |
City Of Hope |
Adeno-associated virus vector variants for high efficiency genome editing and methods thereof
|
|
WO2016046635A1
(en)
|
2014-09-25 |
2016-03-31 |
Institut Pasteur |
Methods for characterizing human papillomavirus associated cervical lesions
|
|
WO2016049258A2
(en)
|
2014-09-25 |
2016-03-31 |
The Broad Institute Inc. |
Functional screening with optimized functional crispr-cas systems
|
|
US20160090603A1
(en)
|
2014-09-30 |
2016-03-31 |
Sandia Corporation |
Delivery platforms for the domestication of algae and plants
|
|
EP3201340B1
(en)
|
2014-10-01 |
2020-12-02 |
The General Hospital Corporation |
Methods for increasing efficiency of nuclease-induced homology-directed repair
|
|
CN113930455A
(zh)
|
2014-10-09 |
2022-01-14 |
生命技术公司 |
Crispr寡核苷酸和基因剪辑
|
|
CA2963840A1
(en)
|
2014-10-09 |
2016-04-14 |
Seattle Children's Hospital (dba Seattle Children's Research Institute) |
Long poly(a) plasmids and methods for introduction of long poly(a) sequences into the plasmid
|
|
EP3204496A1
(en)
|
2014-10-10 |
2017-08-16 |
Editas Medicine, Inc. |
Compositions and methods for promoting homology directed repair
|
|
EP3204032B1
(en)
|
2014-10-10 |
2024-03-27 |
Massachusetts Eye & Ear Infirmary |
Chimeric molecule comprising crispr/cas or cas9 nuclease and at least one guide rna targeting pmca2 gene locus and fused, complexed or linked to an anionic fluorescent protein, and its use in the treatment of deafness or disorders thereof
|
|
WO2016061073A1
(en)
|
2014-10-14 |
2016-04-21 |
Memorial Sloan-Kettering Cancer Center |
Composition and method for in vivo engineering of chromosomal rearrangements
|
|
US10428310B2
(en)
|
2014-10-15 |
2019-10-01 |
Regeneron Pharmaceuticals, Inc. |
Methods and compositions for generating or maintaining pluripotent cells
|
|
EP3207131B1
(en)
|
2014-10-17 |
2022-09-28 |
Howard Hughes Medical Institute |
Genomic probes
|
|
WO2016061481A1
(en)
|
2014-10-17 |
2016-04-21 |
The Penn State Research Foundation |
Methods and compositions for multiplex rna guided genome editing and other rna technologies
|
|
CN104342457A
(zh)
|
2014-10-17 |
2015-02-11 |
杭州师范大学 |
一种将外源基因定点整合到靶标基因的方法
|
|
BR112017008082A2
(pt)
|
2014-10-20 |
2017-12-26 |
Envirologix Inc |
composições e métodos para detectar um vírus de rna
|
|
WO2016077052A2
(en)
|
2014-10-22 |
2016-05-19 |
President And Fellows Of Harvard College |
Evolution of proteases
|
|
US20170306306A1
(en)
|
2014-10-24 |
2017-10-26 |
Life Technologies Corporation |
Compositions and Methods for Enhancing Homologous Recombination
|
|
EP3212788A2
(en)
|
2014-10-27 |
2017-09-06 |
The Broad Institute, Inc. |
Compositions, methods and use of synthetic lethal screening
|
|
US10731143B2
(en)
|
2014-10-28 |
2020-08-04 |
Agrivida, Inc. |
Methods and compositions for stabilizing trans-splicing intein modified proteases
|
|
EP3212770B1
(en)
|
2014-10-29 |
2022-06-29 |
Massachusetts Eye & Ear Infirmary |
Methods for efficient delivery of therapeutic molecules in vitro and in vivo
|
|
EP3212165B1
(en)
|
2014-10-30 |
2024-02-28 |
President and Fellows of Harvard College |
Delivery of negatively charged proteins using cationic lipids
|
|
MA40880A
(fr)
|
2014-10-30 |
2017-09-05 |
Temple Univ Of The Commonwealth |
Éradication guidée par l'arn du virus jc humain et d'autres polyomavirus
|
|
US9816080B2
(en)
|
2014-10-31 |
2017-11-14 |
President And Fellows Of Harvard College |
Delivery of CAS9 via ARRDC1-mediated microvesicles (ARMMs)
|
|
JP6788584B2
(ja)
|
2014-10-31 |
2020-11-25 |
マサチューセッツ インスティテュート オブ テクノロジー |
Crisprについての超並列コンビナトリアル遺伝学
|
|
AU2015339744B2
(en)
|
2014-10-31 |
2021-03-25 |
The Trustees Of The University Of Pennsylvania |
Altering gene expression in CART cells and uses thereof
|
|
WO2016072936A1
(en)
|
2014-11-03 |
2016-05-12 |
Nanyang Technological University |
Novel recombinant expression systems
|
|
CN104404036B
(zh)
|
2014-11-03 |
2017-12-01 |
赛业(苏州)生物科技有限公司 |
基于CRISPR/Cas9技术的条件性基因敲除方法
|
|
CN104504304B
(zh)
|
2014-11-03 |
2017-08-25 |
深圳先进技术研究院 |
一种成簇的规律间隔的短回文重复序列识别方法及装置
|
|
ES2800168T3
(es)
|
2014-11-04 |
2020-12-28 |
Univ Kobe Nat Univ Corp |
Procedimiento de modificación de una secuencia genómica para introducir una mutación específica en una secuencia de ADN diana por reacción de eliminación de base, y complejo molecular usado en el mismo
|
|
WO2016073559A1
(en)
|
2014-11-05 |
2016-05-12 |
The Regents Of The University Of California |
Methods for autocatalytic genome editing and neutralizing autocatalytic genome editing
|
|
DK3215611T3
(da)
|
2014-11-06 |
2019-11-25 |
Du Pont |
Peptid-medieret indgivelse af rna-guidet endonuklease i celler
|
|
CA2963820A1
(en)
|
2014-11-07 |
2016-05-12 |
Editas Medicine, Inc. |
Methods for improving crispr/cas-mediated genome-editing
|
|
US10577649B2
(en)
|
2014-11-11 |
2020-03-03 |
Illumina, Inc. |
Polynucleotide amplification using CRISPR-Cas systems
|
|
US20170369848A1
(en)
|
2014-11-11 |
2017-12-28 |
Q Therapeutics, Inc. |
Engineering mesenchymal stem cells using homologous recombination
|
|
KR101828933B1
(ko)
|
2014-11-14 |
2018-02-14 |
기초과학연구원 |
유전체에서 유전자 가위의 비표적 위치를 검출하는 방법
|
|
DK3218490T3
(en)
|
2014-11-15 |
2019-02-18 |
Zumutor Biologics Inc |
DNA BINDING DOMAIN OF CRISPR SYSTEM FOR PRODUCING NON-FUCOSYLED AND PARTICULAR FUCOSYLED PROTEINS
|
|
WO2016080097A1
(ja)
|
2014-11-17 |
2016-05-26 |
国立大学法人東京医科歯科大学 |
簡便で高効率の遺伝子改変非ヒト哺乳動物の作製方法
|
|
JP2017534294A
(ja)
|
2014-11-19 |
2017-11-24 |
インスティチュート フォー ベーシック サイエンスInstitute For Basic Science |
二つのベクターから発現されたcas9タンパク質を利用した遺伝子発現調節方法
|
|
US11319555B2
(en)
|
2014-11-20 |
2022-05-03 |
Duke University |
Compositions, systems and methods for cell therapy
|
|
CN107208078B
(zh)
|
2014-11-21 |
2021-07-16 |
瑞泽恩制药公司 |
使用成对向导rna进行靶向遗传修饰的方法和组合物
|
|
US10227661B2
(en)
|
2014-11-21 |
2019-03-12 |
GeneWeave Biosciences, Inc. |
Sequence-specific detection and phenotype determination
|
|
WO2016086177A2
(en)
|
2014-11-25 |
2016-06-02 |
Drexel University |
Compositions and methods for hiv quasi-species excision from hiv-1-infected patients
|
|
JP6860483B2
(ja)
|
2014-11-26 |
2021-04-14 |
テクノロジー イノベーション モメンタム ファンド(イスラエル)リミテッド パートナーシップTechnology Innovation Momentum Fund(israel)Limited Partnership |
細菌遺伝子の標的化削減
|
|
CN105695485B
(zh)
|
2014-11-27 |
2020-02-21 |
中国科学院上海生命科学研究院 |
一种用于丝状真菌Crispr-Cas系统的Cas9编码基因及其应用
|
|
US20180105834A1
(en)
|
2014-11-27 |
2018-04-19 |
Institute Of Animal Sciences, Chinese Academy Of Agrigultural Sciences |
A method of site-directed insertion to h11 locus in pigs by using site-directed cutting system
|
|
GB201421096D0
(en)
|
2014-11-27 |
2015-01-14 |
Imp Innovations Ltd |
Genome editing methods
|
|
CA2968808A1
(en)
|
2014-11-27 |
2016-06-02 |
Danziger Innovations Ltd. |
Nucleic acid constructs for genome editing
|
|
US10479997B2
(en)
|
2014-12-01 |
2019-11-19 |
Novartis Ag |
Compositions and methods for diagnosis and treatment of prostate cancer
|
|
US20170266320A1
(en)
|
2014-12-01 |
2017-09-21 |
President And Fellows Of Harvard College |
RNA-Guided Systems for In Vivo Gene Editing
|
|
US10900034B2
(en)
|
2014-12-03 |
2021-01-26 |
Agilent Technologies, Inc. |
Guide RNA with chemical modifications
|
|
CN104450774A
(zh)
|
2014-12-04 |
2015-03-25 |
中国农业科学院作物科学研究所 |
一种大豆CRISPR/Cas9体系的构建及其在大豆基因修饰中的应用
|
|
CN107208079B
(zh)
|
2014-12-05 |
2021-06-29 |
应用干细胞有限公司 |
整合转基因的位点定向crispr/重组酶组合物和方法
|
|
CN104531704B
(zh)
|
2014-12-09 |
2019-05-21 |
中国农业大学 |
利用CRISPR-Cas9系统敲除动物FGF5基因的方法
|
|
CN104531705A
(zh)
|
2014-12-09 |
2015-04-22 |
中国农业大学 |
利用CRISPR-Cas9系统敲除动物myostatin基因的方法
|
|
EP3229586B1
(en)
|
2014-12-10 |
2025-07-30 |
Regents of the University of Minnesota |
Genetically modified cells, tissues, and organs for treating disease
|
|
EP3230445B1
(en)
|
2014-12-12 |
2024-01-24 |
Tod M. Woolf |
Compositions and methods for editing nucleic acids in cells utilizing oligonucleotides
|
|
EP3985115A1
(en)
|
2014-12-12 |
2022-04-20 |
The Broad Institute, Inc. |
Protected guide rnas (pgrnas)
|
|
WO2016094872A1
(en)
|
2014-12-12 |
2016-06-16 |
The Broad Institute Inc. |
Dead guides for crispr transcription factors
|
|
US20170362580A1
(en)
|
2014-12-12 |
2017-12-21 |
James Zhu |
Methods and compositions for selectively eliminating cells of interest
|
|
WO2016094880A1
(en)
|
2014-12-12 |
2016-06-16 |
The Broad Institute Inc. |
Delivery, use and therapeutic applications of crispr systems and compositions for genome editing as to hematopoietic stem cells (hscs)
|
|
CN104480144B
(zh)
|
2014-12-12 |
2017-04-12 |
武汉大学 |
用于艾滋病基因治疗的CRISPR/Cas9重组慢病毒载体及其慢病毒
|
|
WO2016094874A1
(en)
|
2014-12-12 |
2016-06-16 |
The Broad Institute Inc. |
Escorted and functionalized guides for crispr-cas systems
|
|
EP3234136B1
(en)
|
2014-12-16 |
2024-08-21 |
C3J Therapeutics, Inc. |
Compositions of and methods for in vitro viral genome engineering
|
|
KR102350405B1
(ko)
|
2014-12-16 |
2022-01-11 |
다니스코 유에스 인크. |
진균 게놈 변형 시스템 및 사용 방법
|
|
ES2810375T3
(es)
|
2014-12-17 |
2021-03-08 |
Proqr Therapeutics Ii Bv |
Edición direccionada de ARN
|
|
AU2015367317A1
(en)
|
2014-12-17 |
2017-06-01 |
Cellectis |
Inhibitory chimeric antigen receptor (iCAR or N-CAR) expressing non-T cell transduction domain
|
|
EP3234117B1
(en)
|
2014-12-17 |
2021-03-03 |
DuPont US Holding, LLC |
Compositions and methods for efficient gene editing in e. coli using guide rna/cas endonuclease systems in combination with circular polynucleotide modification templates
|
|
WO2016097751A1
(en)
|
2014-12-18 |
2016-06-23 |
The University Of Bath |
Method of cas9 mediated genome engineering
|
|
CN107208096B
(zh)
|
2014-12-18 |
2021-02-12 |
综合基因技术公司 |
基于crispr的组合物和使用方法
|
|
CN104745626B
(zh)
|
2014-12-19 |
2018-05-01 |
中国航天员科研训练中心 |
一种条件性基因敲除动物模型的快速构建方法及应用
|
|
EP3234192B1
(en)
|
2014-12-19 |
2021-07-14 |
The Broad Institute, Inc. |
Unbiased identification of double-strand breaks and genomic rearrangement by genome-wide insert capture sequencing
|
|
AU2015364286B2
(en)
|
2014-12-20 |
2021-11-04 |
Arc Bio, Llc |
Compositions and methods for targeted depletion, enrichment, and partitioning of nucleic acids using CRISPR/Cas system proteins
|
|
CN104560864B
(zh)
|
2014-12-22 |
2017-08-11 |
中国科学院微生物研究所 |
利用CRISPR‑Cas9系统构建的敲除IFN‑β基因的293T细胞系
|
|
US10190106B2
(en)
|
2014-12-22 |
2019-01-29 |
Univesity Of Massachusetts |
Cas9-DNA targeting unit chimeras
|
|
WO2016106236A1
(en)
|
2014-12-23 |
2016-06-30 |
The Broad Institute Inc. |
Rna-targeting system
|
|
WO2016106239A1
(en)
|
2014-12-23 |
2016-06-30 |
The Regents Of The University Of California |
Methods and compositions for nucleic acid integration
|
|
CA2968939A1
(en)
|
2014-12-24 |
2016-06-30 |
The Johns Hopkins University |
Systems and methods for genome modification and regulation
|
|
AU2015101792A4
(en)
|
2014-12-24 |
2016-01-28 |
Massachusetts Institute Of Technology |
Engineering of systems, methods and optimized enzyme and guide scaffolds for sequence manipulation
|
|
AU2015369725A1
(en)
|
2014-12-24 |
2017-06-29 |
Massachusetts Institute Of Technology |
CRISPR having or associated with destabilization domains
|
|
CN104651398A
(zh)
|
2014-12-24 |
2015-05-27 |
杭州师范大学 |
利用CRISPR-Cas9特异敲出microRNA基因家族的方法
|
|
WO2016104716A1
(ja)
|
2014-12-26 |
2016-06-30 |
国立研究開発法人理化学研究所 |
遺伝子のノックアウト方法
|
|
US20180002706A1
(en)
|
2014-12-30 |
2018-01-04 |
University Of South Florida |
Methods and compositions for cloning into large vectors
|
|
CN104498493B
(zh)
|
2014-12-30 |
2017-12-26 |
武汉大学 |
CRISPR/Cas9特异性敲除乙型肝炎病毒的方法以及用于特异性靶向HBV DNA的gRNA
|
|
WO2016108926A1
(en)
|
2014-12-30 |
2016-07-07 |
The Broad Institute Inc. |
Crispr mediated in vivo modeling and genetic screening of tumor growth and metastasis
|
|
SG11201704272YA
(en)
|
2014-12-31 |
2017-06-29 |
Synthetic Genomics Inc |
Compositions and methods for high efficiency in vivo genome editing
|
|
CN104651399B
(zh)
|
2014-12-31 |
2018-11-16 |
广西大学 |
一种利用CRISPR/Cas系统在猪胚胎细胞中实现基因敲除的方法
|
|
CN108064280B
(zh)
|
2015-01-06 |
2021-10-29 |
延世大学校产学协力团 |
利用以凝血因子viii基因为靶的核酸内切酶的a型血友病治疗用组合物
|
|
US10619170B2
(en)
|
2015-01-06 |
2020-04-14 |
Dsm Ip Assets B.V. |
CRISPR-CAS system for a yeast host cell
|
|
DK3242950T3
(da)
|
2015-01-06 |
2021-12-20 |
Dsm Ip Assets Bv |
Crispr-cas-system til en trådformet svampeværtscelle
|
|
WO2016110511A1
(en)
|
2015-01-06 |
2016-07-14 |
Dsm Ip Assets B.V. |
A crispr-cas system for a lipolytic yeast host cell
|
|
CN104651392B
(zh)
|
2015-01-06 |
2018-07-31 |
华南农业大学 |
一种利用CRISPR/Cas9系统定点突变P/TMS12-1获得温敏不育系的方法
|
|
CN104593422A
(zh)
|
2015-01-08 |
2015-05-06 |
中国农业大学 |
一种抗蓝耳病克隆猪的制备方法
|
|
US20180155708A1
(en)
|
2015-01-08 |
2018-06-07 |
President And Fellows Of Harvard College |
Split Cas9 Proteins
|
|
WO2016112351A1
(en)
|
2015-01-09 |
2016-07-14 |
Bio-Rad Laboratories, Inc. |
Detection of genome editing
|
|
CN107250373A
(zh)
|
2015-01-12 |
2017-10-13 |
麻省理工学院 |
通过微流体递送实现的基因编辑
|
|
US11208638B2
(en)
|
2015-01-12 |
2021-12-28 |
The Regents Of The University Of California |
Heterodimeric Cas9 and methods of use thereof
|
|
WO2016112963A1
(en)
|
2015-01-13 |
2016-07-21 |
Riboxx Gmbh |
Delivery of biomolecules into cells
|
|
MA41349A
(fr)
|
2015-01-14 |
2017-11-21 |
Univ Temple |
Éradication de l'herpès simplex de type i et d'autres virus de l'herpès associés guidée par arn
|
|
CN107405378B
(zh)
|
2015-01-14 |
2021-09-24 |
埃克斯-马赛大学 |
用于治疗与非降解异常蛋白的积聚相关的病症或癌症的蛋白酶体抑制剂
|
|
CN107429263A
(zh)
|
2015-01-15 |
2017-12-01 |
斯坦福大学托管董事会 |
调控基因组编辑的方法
|
|
CN104611370A
(zh)
|
2015-01-16 |
2015-05-13 |
深圳市科晖瑞生物医药有限公司 |
一种剔除β2-微球蛋白基因片段的方法
|
|
CN105802991B
(zh)
|
2015-01-19 |
2021-06-29 |
中国科学院遗传与发育生物学研究所 |
一种通过基因瞬时表达对植物定点改造的方法
|
|
CN104725626B
(zh)
|
2015-01-22 |
2016-06-29 |
漳州亚邦化学有限公司 |
一种适用于人造石英石的不饱和树脂的制备方法
|
|
CN105821072A
(zh)
|
2015-01-23 |
2016-08-03 |
深圳华大基因研究院 |
用于DNA组装的CRISPR-Cas9系统及DNA组装方法
|
|
US20180023139A1
(en)
|
2015-01-26 |
2018-01-25 |
Cold Spring Harbor Laboratory |
Methods of identifying essential protein domains
|
|
US10059940B2
(en)
|
2015-01-27 |
2018-08-28 |
Minghong Zhong |
Chemically ligated RNAs for CRISPR/Cas9-lgRNA complexes as antiviral therapeutic agents
|
|
CN104561095B
(zh)
|
2015-01-27 |
2017-08-22 |
深圳市国创纳米抗体技术有限公司 |
一种能够生产人神经生长因子的转基因小鼠的制备方法
|
|
LT3250691T
(lt)
|
2015-01-28 |
2023-09-11 |
Caribou Biosciences, Inc. |
Crispr hibridiniai dnr/rnr polinukleotidai ir naudojimo būdai
|
|
EP3250689B1
(en)
|
2015-01-28 |
2020-11-04 |
The Regents of The University of California |
Methods and compositions for labeling a single-stranded target nucleic acid
|
|
EP3798302A1
(fr)
|
2015-01-29 |
2021-03-31 |
Meiogenix |
Procede pour induire des recombinaisons meiotiques ciblees
|
|
AU2016211161C1
(en)
|
2015-01-30 |
2023-11-23 |
The Regents Of The University Of California |
Protein delivery in primary hematopoietic cells
|
|
US10494646B2
(en)
|
2015-02-02 |
2019-12-03 |
Meiragtx Uk Ii Limited |
Regulation of gene expression by aptamer-mediated modulation of alternative splicing
|
|
CN104593418A
(zh)
|
2015-02-06 |
2015-05-06 |
中国医学科学院医学实验动物研究所 |
一种人源化大鼠药物评价动物模型建立的方法
|
|
US10676726B2
(en)
|
2015-02-09 |
2020-06-09 |
Duke University |
Compositions and methods for epigenome editing
|
|
KR101584933B1
(ko)
|
2015-02-10 |
2016-01-13 |
성균관대학교산학협력단 |
항생제 내성 억제용 재조합 벡터 및 이의 용도
|
|
WO2016130697A1
(en)
|
2015-02-11 |
2016-08-18 |
Memorial Sloan Kettering Cancer Center |
Methods and kits for generating vectors that co-express multiple target molecules
|
|
CN104928321B
(zh)
|
2015-02-12 |
2018-06-01 |
中国科学院西北高原生物研究所 |
一种由Crispr/Cas9诱导的鳞片缺失斑马鱼模式及建立方法
|
|
CN104726494B
(zh)
|
2015-02-12 |
2018-10-23 |
中国人民解放军第二军医大学 |
CRISPR-Cas9技术构建染色体易位干细胞及动物模型的方法
|
|
EP3256170B1
(en)
|
2015-02-13 |
2020-09-23 |
University of Massachusetts |
Compositions and methods for transient delivery of nucleases
|
|
US20160244784A1
(en)
|
2015-02-15 |
2016-08-25 |
Massachusetts Institute Of Technology |
Population-Hastened Assembly Genetic Engineering
|
|
WO2016132122A1
(en)
|
2015-02-17 |
2016-08-25 |
University Of Edinburgh |
Assay construct
|
|
WO2016133165A1
(ja)
|
2015-02-19 |
2016-08-25 |
国立大学法人徳島大学 |
Cas9 mRNAを哺乳動物の受精卵にエレクトロポレーションにより導入する方法
|
|
EP3262172A2
(en)
|
2015-02-23 |
2018-01-03 |
Crispr Therapeutics AG |
Materials and methods for treatment of hemoglobinopathies
|
|
WO2016137949A1
(en)
|
2015-02-23 |
2016-09-01 |
Voyager Therapeutics, Inc. |
Regulatable expression using adeno-associated virus (aav)
|
|
WO2016135559A2
(en)
|
2015-02-23 |
2016-09-01 |
Crispr Therapeutics Ag |
Materials and methods for treatment of human genetic diseases including hemoglobinopathies
|
|
BR112017018327A2
(pt)
|
2015-02-25 |
2018-04-17 |
Pioneer Hi-Bred International, Inc. |
método para a expressão regulada de um complexo, planta ou célula vegetal, semente, método para modificação de uma sequência, método para alteração da expressão de pelo menos um polinucleotídeo
|
|
KR20160103953A
(ko)
|
2015-02-25 |
2016-09-02 |
연세대학교 산학협력단 |
Crispr 시스템을 이용한 다중 위치 염기서열의 동시 포획 방법
|
|
WO2016135507A1
(en)
|
2015-02-27 |
2016-09-01 |
University Of Edinburgh |
Nucleic acid editing systems
|
|
CN104805099B
(zh)
|
2015-03-02 |
2018-04-13 |
中国人民解放军第二军医大学 |
一种安全编码Cas9蛋白的核酸分子及其表达载体
|
|
JP6817215B2
(ja)
|
2015-03-03 |
2021-01-20 |
ザ ジェネラル ホスピタル コーポレイション |
変更PAM特異性を有する遺伝子操作CRISPR−Cas9ヌクレアーゼ
|
|
CN104673816A
(zh)
|
2015-03-05 |
2015-06-03 |
广东医学院 |
一种pCr-NHEJ载体及其构建方法及其用于细菌基因定点敲除的应用
|
|
CN104651401B
(zh)
|
2015-03-05 |
2019-03-08 |
东华大学 |
一种mir-505双等位基因敲除的方法
|
|
WO2016145150A2
(en)
|
2015-03-11 |
2016-09-15 |
The Broad Institute Inc. |
Selective treatment of prmt5 dependent cancer
|
|
US20160264934A1
(en)
|
2015-03-11 |
2016-09-15 |
The General Hospital Corporation |
METHODS FOR MODULATING AND ASSAYING m6A IN STEM CELL POPULATIONS
|
|
GB201504223D0
(en)
|
2015-03-12 |
2015-04-29 |
Genome Res Ltd |
Biallelic genetic modification
|
|
CA2979292A1
(en)
|
2015-03-12 |
2016-09-15 |
Institute Of Genetics And Developmental Biology, Chinese Academy Of Sciences |
Method for improving ability to resist against intrusive dna viruses of plant
|
|
EP3858992A1
(en)
|
2015-03-13 |
2021-08-04 |
The Jackson Laboratory |
A three-component crispr/cas complex system and uses thereof
|
|
CN106032540B
(zh)
|
2015-03-16 |
2019-10-25 |
中国科学院上海生命科学研究院 |
CRISPR/Cas9核酸内切酶体系的腺相关病毒载体构建及其用途
|
|
US12043835B2
(en)
|
2015-03-16 |
2024-07-23 |
Institute Of Genetics And Developmental Biology, Chinese Academy Of Sciences |
Method for making site-directed modification to plant genomes by using non-inheritable materials
|
|
WO2016149484A2
(en)
|
2015-03-17 |
2016-09-22 |
Temple University Of The Commonwealth System Of Higher Education |
Compositions and methods for specific reactivation of hiv latent reservoir
|
|
US10066256B2
(en)
|
2015-03-17 |
2018-09-04 |
Bio-Rad Laboratories, Inc. |
Detection of genome editing
|
|
MA41382A
(fr)
|
2015-03-20 |
2017-11-28 |
Univ Temple |
Édition génique basée sur le système crispr/endonucléase à induction par tat
|
|
US20180163196A1
(en)
|
2015-03-20 |
2018-06-14 |
Danmarks Tekniske Universitet |
Crispr/cas9 based engineering of actinomycetal genomes
|
|
CN104726449A
(zh)
|
2015-03-23 |
2015-06-24 |
国家纳米科学中心 |
一种用于预防和/或治疗HIV的CRISPR-Cas9系统及其制备方法和用途
|
|
CN106148416B
(zh)
|
2015-03-24 |
2019-12-17 |
华东师范大学 |
Cyp基因敲除大鼠的培育方法及其肝微粒体的制备方法
|
|
WO2016154596A1
(en)
|
2015-03-25 |
2016-09-29 |
Editas Medicine, Inc. |
Crispr/cas-related methods, compositions and components
|
|
EP3274453B1
(en)
|
2015-03-26 |
2021-01-27 |
Editas Medicine, Inc. |
Crispr/cas-mediated gene conversion
|
|
WO2016161004A1
(en)
|
2015-03-30 |
2016-10-06 |
The Board Of Regents Of The Nevada System Of Higher Educ. On Behalf Of The University Of Nevada, La |
Compositions comprising talens and methods of treating hiv
|
|
EP4600366A3
(en)
|
2015-03-31 |
2025-10-22 |
SOHM, Inc. |
Cas 9 retroviral integrase systems for targeted incorporation of a dna sequence into a genome of a cell
|
|
AU2016244033A1
(en)
|
2015-04-01 |
2017-10-19 |
Editas Medicine, Inc. |
CRISPR/CAS-related methods and compositions for treating Duchenne Muscular Dystrophy and Becker Muscular Dystrophy
|
|
WO2016161260A1
(en)
|
2015-04-02 |
2016-10-06 |
Agenovir Corporation |
Gene delivery methods and compositions
|
|
AU2016243052C1
(en)
|
2015-04-03 |
2022-11-24 |
Dana-Farber Cancer Institute, Inc. |
Composition and methods of genome editing of B-cells
|
|
CN106167810A
(zh)
|
2015-04-03 |
2016-11-30 |
内蒙古中科正标生物科技有限责任公司 |
基于CRISPR/Cas9技术的单子叶植物基因敲除载体及其应用
|
|
US20170166928A1
(en)
|
2015-04-03 |
2017-06-15 |
Whitehead Institute For Biomedical Research |
Compositions And Methods For Genetically Modifying Yeast
|
|
EA201792226A1
(ru)
|
2015-04-06 |
2018-08-31 |
САБДОМЭН, ЭлЭлСи |
Полипептиды, содержащие de novo связывающий домен, и их применение
|
|
JP6873911B2
(ja)
|
2015-04-06 |
2021-05-19 |
ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティー |
初代細胞において標的核酸の遺伝子調節を誘導するためにインビトロで行う方法
|
|
US11214779B2
(en)
|
2015-04-08 |
2022-01-04 |
University of Pittsburgh—of the Commonwealth System of Higher Education |
Activatable CRISPR/CAS9 for spatial and temporal control of genome editing
|
|
WO2016167300A1
(ja)
|
2015-04-13 |
2016-10-20 |
国立大学法人東京大学 |
光依存的に又は薬物存在下でヌクレアーゼ活性若しくはニッカーゼ活性を示す、又は標的遺伝子の発現を抑制若しくは活性化するポリペプチドのセット
|
|
US10155938B2
(en)
|
2015-04-14 |
2018-12-18 |
City Of Hope |
Coexpression of CAS9 and TREX2 for targeted mutagenesis
|
|
GB201506509D0
(en)
|
2015-04-16 |
2015-06-03 |
Univ Wageningen |
Nuclease-mediated genome editing
|
|
US11299729B2
(en)
|
2015-04-17 |
2022-04-12 |
President And Fellows Of Harvard College |
Vector-based mutagenesis system
|
|
US10738290B2
(en)
|
2015-04-21 |
2020-08-11 |
Novartis Ag |
RNA-guided gene editing system and uses thereof
|
|
CN104805118A
(zh)
|
2015-04-22 |
2015-07-29 |
扬州大学 |
一种苏禽黄鸡胚胎干细胞特定基因进行靶向敲除方法
|
|
CN104762321A
(zh)
|
2015-04-22 |
2015-07-08 |
东北林业大学 |
基于CRISPR/Cas9系统靶向敲除KHV基因的敲除载体构建方法及其crRNA原件
|
|
US20180298340A1
(en)
|
2015-04-24 |
2018-10-18 |
The Regents Of The University Of California |
Systems for detecting, monitoring or treating diseases or conditions using engineered cells and methods for making and using them
|
|
US11268158B2
(en)
|
2015-04-24 |
2022-03-08 |
St. Jude Children's Research Hospital, Inc. |
Assay for safety assessment of therapeutic genetic manipulations, gene therapy vectors and compounds
|
|
CA2982966C
(en)
|
2015-04-24 |
2024-02-20 |
Editas Medicine, Inc. |
Evaluation of cas9 molecule/guide rna molecule complexes
|
|
EP3288594B1
(en)
|
2015-04-27 |
2022-06-29 |
The Trustees of The University of Pennsylvania |
Dual aav vector system for crispr/cas9 mediated correction of human disease
|
|
EP3289081B1
(en)
|
2015-04-27 |
2019-03-27 |
Genethon |
Compositions and methods for the treatment of nucleotide repeat expansion disorders
|
|
EP3087974A1
(en)
|
2015-04-29 |
2016-11-02 |
Rodos BioTarget GmbH |
Targeted nanocarriers for targeted drug delivery of gene therapeutics
|
|
US20190002920A1
(en)
|
2015-04-30 |
2019-01-03 |
The Brigham And Women's Hospital, Inc. |
Methods and kits for cloning-free genome editing
|
|
ES2898917T3
(es)
|
2015-04-30 |
2022-03-09 |
Univ Columbia |
Tratamiento génico para enfermedades autosómicas dominantes
|
|
EP4015633A1
(en)
|
2015-05-01 |
2022-06-22 |
Precision Biosciences, Inc. |
Precise deletion of chromosomal sequences in vivo and treatment of nucleotide repeat expansion disorders using engineered nucleases
|
|
WO2016179038A1
(en)
|
2015-05-01 |
2016-11-10 |
Spark Therapeutics, Inc. |
ADENO-ASSOCIATED VIRUS-MEDIATED CRISPR-Cas9 TREATMENT OF OCULAR DISEASE
|
|
CN104894068A
(zh)
|
2015-05-04 |
2015-09-09 |
南京凯地生物科技有限公司 |
一种利用CRISPR/Cas9制备CAR-T细胞的方法
|
|
US11845928B2
(en)
|
2015-05-04 |
2023-12-19 |
Tsinghua University |
Methods and kits for fragmenting DNA
|
|
RU2017142352A
(ru)
|
2015-05-06 |
2019-06-06 |
Снипр Текнолоджиз Лимитед |
Изменение популяций микроорганизмов и модификация микробиоты
|
|
GB2531454A
(en)
|
2016-01-10 |
2016-04-20 |
Snipr Technologies Ltd |
Recombinogenic nucleic acid strands in situ
|
|
EP3763814A1
(en)
|
2015-05-08 |
2021-01-13 |
The Children's Medical Center Corporation |
Targeting bcl11a enhancer functional regions for fetal hemoglobin reinduction
|
|
WO2016182893A1
(en)
|
2015-05-08 |
2016-11-17 |
Teh Broad Institute Inc. |
Functional genomics using crispr-cas systems for saturating mutagenesis of non-coding elements, compositions, methods, libraries and applications thereof
|
|
WO2016183236A1
(en)
|
2015-05-11 |
2016-11-17 |
Editas Medicine, Inc. |
Crispr/cas-related methods and compositions for treating hiv infection and aids
|
|
WO2016182959A1
(en)
|
2015-05-11 |
2016-11-17 |
Editas Medicine, Inc. |
Optimized crispr/cas9 systems and methods for gene editing in stem cells
|
|
CA2984013A1
(en)
|
2015-05-12 |
2016-11-17 |
Sangamo Therapeutics, Inc. |
Nuclease-mediated regulation of gene expression
|
|
KR101785847B1
(ko)
|
2015-05-12 |
2017-10-17 |
연세대학교 산학협력단 |
선형 이중가닥 DNA를 활용한 CRISPR/Cas9 시스템을 이용한 표적 유전체 교정
|
|
US11267899B2
(en)
|
2015-05-13 |
2022-03-08 |
Zumutor Biologics Inc. |
Afucosylated protein, cell expressing said protein and associated methods
|
|
CN105886498A
(zh)
|
2015-05-13 |
2016-08-24 |
沈志荣 |
CRISPR-Cas9特异性敲除人PCSK9基因的方法以及用于特异性靶向PCSK9基因的sgRNA
|
|
WO2016183402A2
(en)
|
2015-05-13 |
2016-11-17 |
President And Fellows Of Harvard College |
Methods of making and using guide rna for use with cas9 systems
|
|
CN108136047B
(zh)
|
2015-05-13 |
2022-12-13 |
西雅图儿童医院(Dba西雅图儿童研究所) |
提高原代细胞中基于核酸内切酶的基因编辑
|
|
US20180291372A1
(en)
|
2015-05-14 |
2018-10-11 |
Massachusetts Institute Of Technology |
Self-targeting genome editing system
|
|
US11535871B2
(en)
|
2015-05-14 |
2022-12-27 |
University Of Southern California |
Optimized gene editing utilizing a recombinant endonuclease system
|
|
US20180142236A1
(en)
|
2015-05-15 |
2018-05-24 |
Ge Healthcare Dharmacon, Inc. |
Synthetic single guide rna for cas9-mediated gene editing
|
|
AU2016265560B2
(en)
|
2015-05-15 |
2022-07-28 |
Pioneer Hi-Bred International, Inc. |
Rapid characterization of Cas endonuclease systems, PAM sequences and guide RNA elements
|
|
CN114657180A
(zh)
|
2015-05-16 |
2022-06-24 |
建新公司 |
深内含子突变的基因编辑
|
|
EP3298149A1
(en)
|
2015-05-18 |
2018-03-28 |
King Abdullah University Of Science And Technology |
Method of inhibiting plant virus pathogen infections by crispr/cas9-mediated interference
|
|
CN104846010B
(zh)
|
2015-05-18 |
2018-07-06 |
安徽省农业科学院水稻研究所 |
一种删除转基因水稻筛选标记基因的方法
|
|
EP3095870A1
(en)
|
2015-05-19 |
2016-11-23 |
Kws Saat Se |
Methods for the in planta transformation of plants and manufacturing processes and products based and obtainable therefrom
|
|
CN106011104B
(zh)
|
2015-05-21 |
2019-09-27 |
清华大学 |
利用拆分Cas系统进行基因编辑和表达调控方法
|
|
CN105518135B
(zh)
|
2015-05-22 |
2020-11-24 |
深圳市第二人民医院 |
CRISPR-Cas9特异性敲除猪CMAH基因的方法及用于特异性靶向CMAH基因的sgRNA
|
|
WO2016187904A1
(zh)
|
2015-05-22 |
2016-12-01 |
深圳市第二人民医院 |
CRISPR-Cas9特异性敲除猪CMAH基因的方法及用于特异性靶向CMAH基因的sgRNA
|
|
US20160340622A1
(en)
|
2015-05-22 |
2016-11-24 |
Nabil Radi Abdou |
Bar Soap Anchoring Core
|
|
WO2016187717A1
(en)
|
2015-05-26 |
2016-12-01 |
Exerkine Corporation |
Exosomes useful for genome editing
|
|
CN104894075B
(zh)
|
2015-05-28 |
2019-08-06 |
华中农业大学 |
CRISPR/Cas9和Cre/lox系统编辑伪狂犬病毒基因组制备疫苗方法和应用
|
|
CN105624146B
(zh)
|
2015-05-28 |
2019-02-15 |
中国科学院微生物研究所 |
基于CRISPR/Cas9和酿酒酵母细胞内源的同源重组的分子克隆方法
|
|
WO2016191684A1
(en)
|
2015-05-28 |
2016-12-01 |
Finer Mitchell H |
Genome editing vectors
|
|
JP2018516596A
(ja)
|
2015-05-29 |
2018-06-28 |
アジェノビア コーポレーション |
抗ウイルスの方法および組成物
|
|
CN108026536A
(zh)
|
2015-05-29 |
2018-05-11 |
北卡罗来纳州立大学 |
使用crispr核酸筛选细菌、古细菌、藻类和酵母的方法
|
|
CA3000182A1
(en)
|
2015-05-29 |
2016-12-08 |
Agenovir Corporation |
Methods and compositions for treating cells for transplant
|
|
WO2016196273A1
(en)
|
2015-05-29 |
2016-12-08 |
Agenovir Corporation |
Compositions and methods to treat viral infections
|
|
US10117911B2
(en)
|
2015-05-29 |
2018-11-06 |
Agenovir Corporation |
Compositions and methods to treat herpes simplex virus infections
|
|
US20160346362A1
(en)
|
2015-05-29 |
2016-12-01 |
Agenovir Corporation |
Methods and compositions for treating cytomegalovirus infections
|
|
WO2016196499A1
(en)
|
2015-05-29 |
2016-12-08 |
Clark Atlanta University |
Human cell lines mutant for zic2
|
|
GB2543873A
(en)
|
2015-05-29 |
2017-05-03 |
Agenovir Corp |
Compositions and methods for cell targeted HPV treatment
|
|
CA2987684A1
(en)
|
2015-06-01 |
2016-12-08 |
The Hospital For Sick Children |
Delivery of structurally diverse polypeptide cargo into mammalian cells by a bacterial toxin
|
|
EP3919622A1
(en)
|
2015-06-01 |
2021-12-08 |
Temple University - Of The Commonwealth System of Higher Education |
Methods and compositions for rna-guided treatment of hiv infection
|
|
CN105112445B
(zh)
|
2015-06-02 |
2018-08-10 |
广州辉园苑医药科技有限公司 |
一种基于CRISPR-Cas9基因敲除技术的miR-205基因敲除试剂盒
|
|
EP3303634B1
(en)
|
2015-06-03 |
2023-08-30 |
The Regents of The University of California |
Cas9 variants and methods of use thereof
|
|
EP3303585A4
(en)
|
2015-06-03 |
2018-10-31 |
Board of Regents of the University of Nebraska |
Dna editing using single-stranded dna
|
|
US20180245074A1
(en)
|
2015-06-04 |
2018-08-30 |
Protiva Biotherapeutics, Inc. |
Treating hepatitis b virus infection using crispr
|
|
US10626393B2
(en)
|
2015-06-04 |
2020-04-21 |
Arbutus Biopharma Corporation |
Delivering CRISPR therapeutics with lipid nanoparticles
|
|
CN105039339B
(zh)
|
2015-06-05 |
2017-12-19 |
新疆畜牧科学院生物技术研究所 |
一种以RNA介导的特异性敲除绵羊FecB基因的方法及其专用sgRNA
|
|
WO2016196805A1
(en)
|
2015-06-05 |
2016-12-08 |
The Regents Of The University Of California |
Methods and compositions for generating crispr/cas guide rnas
|
|
EP3307887A1
(en)
|
2015-06-09 |
2018-04-18 |
Editas Medicine, Inc. |
Crispr/cas-related methods and compositions for improving transplantation
|
|
EP3307770B1
(en)
|
2015-06-10 |
2020-05-27 |
Firmenich SA |
Method of identifying musk compounds
|
|
US20180177727A1
(en)
|
2015-06-10 |
2018-06-28 |
Board Of Regents, The University Of Texas System |
Use of exosomes for the treatment of disease
|
|
JP6961494B2
(ja)
|
2015-06-10 |
2021-11-05 |
フイルメニツヒ ソシエテ アノニムFirmenich Sa |
匂い物質および芳香の受容体をスクリーニングするための細胞株
|
|
US20160362667A1
(en)
|
2015-06-10 |
2016-12-15 |
Caribou Biosciences, Inc. |
CRISPR-Cas Compositions and Methods
|
|
WO2016198500A1
(en)
|
2015-06-10 |
2016-12-15 |
INSERM (Institut National de la Santé et de la Recherche Médicale) |
Methods and compositions for rna-guided treatment of human cytomegalovirus (hcmv) infection
|
|
CN105492608B
(zh)
|
2015-06-11 |
2021-07-23 |
深圳市第二人民医院 |
CRISPR-Cas9特异性敲除猪PDX1基因的方法及用于特异性靶向PDX1基因的sgRNA
|
|
CN105518139B
(zh)
|
2015-06-11 |
2021-02-02 |
深圳市第二人民医院 |
CRISPR-Cas9特异性敲除猪FGL2基因的方法及用于特异性靶向FGL2基因的sgRNA
|
|
WO2016197356A1
(zh)
|
2015-06-11 |
2016-12-15 |
深圳市第二人民医院 |
CRISPR-Cas9特异性敲除猪SLA-2基因的方法及用于特异性靶向SLA-2基因的sgRNA
|
|
CN105492609A
(zh)
|
2015-06-11 |
2016-04-13 |
深圳市第二人民医院 |
CRISPR-Cas9特异性敲除猪GGTA1基因的方法及用于特异性靶向GGTA1基因的sgRNA
|
|
CN105518140A
(zh)
|
2015-06-11 |
2016-04-20 |
深圳市第二人民医院 |
CRISPR-Cas9特异性敲除猪vWF基因的方法及用于特异性靶向vWF基因的sgRNA
|
|
CN105518138B
(zh)
|
2015-06-11 |
2021-07-27 |
深圳市第二人民医院 |
CRISPR-Cas9特异性敲除猪GFRA1基因的方法及用于特异性靶向GFRA1基因的sgRNA
|
|
CN105593367A
(zh)
|
2015-06-11 |
2016-05-18 |
深圳市第二人民医院 |
CRISPR-Cas9特异性敲除猪SLA-1基因的方法及用于特异性靶向SLA-1基因的sgRNA
|
|
CN106414740A
(zh)
|
2015-06-11 |
2017-02-15 |
深圳市第二人民医院 |
CRISPR‑Cas9特异性敲除猪SLA‑3基因的方法及用于特异性靶向SLA‑3基因的sgRNA
|
|
WO2016197355A1
(zh)
|
2015-06-11 |
2016-12-15 |
深圳市第二人民医院 |
CRISPR-Cas9特异性敲除猪SALL1基因的方法及用于特异性靶向SALL1基因的sgRNA
|
|
GB201510296D0
(en)
|
2015-06-12 |
2015-07-29 |
Univ Wageningen |
Thermostable CAS9 nucleases
|
|
EP3307762B1
(en)
|
2015-06-12 |
2021-12-15 |
The Regents of The University of California |
Reporter cas9 variants and methods of use thereof
|
|
WO2016200263A1
(en)
|
2015-06-12 |
2016-12-15 |
Erasmus University Medical Center Rotterdam |
New crispr assays
|
|
ES2960226T3
(es)
|
2015-06-15 |
2024-03-01 |
Univ North Carolina State |
Métodos y composiciones para la administración eficiente de ácidos nucleicos y antimicrobianos basados en ARN
|
|
WO2016205623A1
(en)
|
2015-06-17 |
2016-12-22 |
North Carolina State University |
Methods and compositions for genome editing in bacteria using crispr-cas9 systems
|
|
US11555207B2
(en)
|
2015-06-17 |
2023-01-17 |
The Uab Research Foundation |
CRISPR/Cas9 complex for introducing a functional polypeptide into cells of blood cell lineage
|
|
JP2018518182A
(ja)
|
2015-06-17 |
2018-07-12 |
ザ ユーエービー リサーチ ファンデーション |
ゲノム編集のためのcrispr/cas9複合体
|
|
WO2016205728A1
(en)
|
2015-06-17 |
2016-12-22 |
Massachusetts Institute Of Technology |
Crispr mediated recording of cellular events
|
|
CA3012607A1
(en)
|
2015-06-18 |
2016-12-22 |
The Broad Institute Inc. |
Crispr enzymes and systems
|
|
US9957501B2
(en)
|
2015-06-18 |
2018-05-01 |
Sangamo Therapeutics, Inc. |
Nuclease-mediated regulation of gene expression
|
|
WO2016205745A2
(en)
|
2015-06-18 |
2016-12-22 |
The Broad Institute Inc. |
Cell sorting
|
|
WO2016205759A1
(en)
|
2015-06-18 |
2016-12-22 |
The Broad Institute Inc. |
Engineering and optimization of systems, methods, enzymes and guide scaffolds of cas9 orthologs and variants for sequence manipulation
|
|
EP3310395A4
(en)
|
2015-06-18 |
2019-05-22 |
Robert D. Bowles |
REGULATION OF RNA GUIDED TRANSCRIPTION AND METHODS OF USE THEREOF FOR THE TREATMENT OF LOMBALGIA
|
|
EP4159856A1
(en)
|
2015-06-18 |
2023-04-05 |
The Broad Institute, Inc. |
Novel crispr enzymes and systems
|
|
US9790490B2
(en)
|
2015-06-18 |
2017-10-17 |
The Broad Institute Inc. |
CRISPR enzymes and systems
|
|
RU2752834C2
(ru)
|
2015-06-18 |
2021-08-09 |
Те Брод Инститьют, Инк. |
Мутации фермента crispr, уменьшающие нецелевые эффекты
|
|
UA120656C2
(uk)
|
2015-06-22 |
2020-01-10 |
Баєр Кропсаєнс Акціенгезельшафт |
Нові алкінілзаміщені 3-фенілпіролідин-2,4-діони та їх застосування як гербіцидів
|
|
GB201511191D0
(en)
|
2015-06-25 |
2015-08-12 |
Immatics Biotechnologies Gmbh |
T-cell epitopes for the immunotherapy of myeloma
|
|
AU2016285724A1
(en)
|
2015-06-29 |
2017-11-16 |
Ionis Pharmaceuticals, Inc. |
Modified CRISPR RNA and modified single CRISPR RNA and uses thereof
|
|
US11279928B2
(en)
|
2015-06-29 |
2022-03-22 |
Massachusetts Institute Of Technology |
Compositions comprising nucleic acids and methods of using the same
|
|
GB201511376D0
(en)
|
2015-06-29 |
2015-08-12 |
Ecolab Usa Inc |
Process for the treatment of produced water from chemical enhanced oil recovery
|
|
AU2016287440B2
(en)
|
2015-06-30 |
2022-02-10 |
Cellectis |
Methods for improving functionality in NK cell by gene inactivation using specific endonuclease
|
|
CN108350446A
(zh)
|
2015-07-02 |
2018-07-31 |
约翰霍普金斯大学 |
基于crispr/cas9的治疗
|
|
US20170009242A1
(en)
|
2015-07-06 |
2017-01-12 |
Whitehead Institute For Biomedical Research |
CRISPR-Mediated Genome Engineering for Protein Depletion
|
|
DK3320091T3
(da)
|
2015-07-06 |
2021-02-01 |
Dsm Ip Assets Bv |
Guide-rna-samlingsvektor
|
|
CN105132451B
(zh)
|
2015-07-08 |
2019-07-23 |
电子科技大学 |
一种CRISPR/Cas9单一转录单元定向修饰骨架载体及其应用
|
|
EP3322797B1
(en)
|
2015-07-13 |
2023-11-29 |
Institut Pasteur |
Improving sequence-specific antimicrobials by blocking dna repair
|
|
US20170014449A1
(en)
|
2015-07-13 |
2017-01-19 |
Elwha LLC, a limited liability company of the State of Delaware |
Site-specific epigenetic editing
|
|
CA2991301A1
(en)
|
2015-07-13 |
2017-01-19 |
Sangamo Therapeutics, Inc. |
Delivery methods and compositions for nuclease-mediated genome engineering
|
|
EP3323890A4
(en)
|
2015-07-14 |
2019-01-30 |
Fukuoka University |
METHOD OF INDUSTRYING SITE-SPECIFIC RNA MUTATIONS, TARGETED EDITING GUIDE RNA USED IN THE METHOD AND TARGET RNA TARGET EDITING GUIDE RNA COMPLEX
|
|
JP7044373B2
(ja)
|
2015-07-15 |
2022-03-30 |
ラトガース,ザ ステート ユニバーシティ オブ ニュージャージー |
ヌクレアーゼ非依存的な標的化遺伝子編集プラットフォームおよびその用途
|
|
MA42895A
(fr)
|
2015-07-15 |
2018-05-23 |
Juno Therapeutics Inc |
Cellules modifiées pour thérapie cellulaire adoptive
|
|
US20170020922A1
(en)
|
2015-07-16 |
2017-01-26 |
Batu Biologics Inc. |
Gene editing for immunological destruction of neoplasia
|
|
WO2017015101A1
(en)
|
2015-07-17 |
2017-01-26 |
University Of Washington |
Methods for maximizing the efficiency of targeted gene correction
|
|
WO2017015015A1
(en)
|
2015-07-17 |
2017-01-26 |
Emory University |
Crispr-associated protein from francisella and uses related thereto
|
|
WO2017015545A1
(en)
|
2015-07-22 |
2017-01-26 |
President And Fellows Of Harvard College |
Evolution of site-specific recombinases
|
|
WO2017015637A1
(en)
|
2015-07-22 |
2017-01-26 |
Duke University |
High-throughput screening of regulatory element function with epigenome editing technologies
|
|
WO2017015567A1
(en)
|
2015-07-23 |
2017-01-26 |
Mayo Foundation For Medical Education And Research |
Editing mitochondrial dna
|
|
CN108025074A
(zh)
|
2015-07-25 |
2018-05-11 |
哈比卜·弗罗斯特 |
用于为癌症和其他病理状态提供治疗或治愈的系统、装置和方法
|
|
CN106399360A
(zh)
|
2015-07-27 |
2017-02-15 |
上海药明生物技术有限公司 |
基于crispr技术敲除fut8基因的方法
|
|
DK3329001T3
(da)
|
2015-07-28 |
2021-12-20 |
Danisco Us Inc |
Genomredigeringssystemer og anvendelsesfremgangsmåder
|
|
CN105063061B
(zh)
|
2015-07-28 |
2018-10-30 |
华南农业大学 |
一种水稻千粒重基因tgw6突变体及其制备方法与应用
|
|
CN106701808A
(zh)
|
2015-07-29 |
2017-05-24 |
深圳华大基因研究院 |
Dna聚合酶i缺陷型菌株及其构建方法
|
|
WO2017019895A1
(en)
|
2015-07-30 |
2017-02-02 |
President And Fellows Of Harvard College |
Evolution of talens
|
|
WO2017069829A2
(en)
|
2015-07-31 |
2017-04-27 |
The Trustees Of Columbia University In The City Of New York |
High-throughput strategy for dissecting mammalian genetic interactions
|
|
CN108472314A
(zh)
|
2015-07-31 |
2018-08-31 |
明尼苏达大学董事会 |
修饰的细胞和治疗方法
|
|
US20180230450A1
(en)
|
2015-08-03 |
2018-08-16 |
President And Fellows Of Harvard College |
Cas9 Genome Editing and Transcriptional Regulation
|
|
WO2017024047A1
(en)
|
2015-08-03 |
2017-02-09 |
Emendobio Inc. |
Compositions and methods for increasing nuclease induced recombination rate in cells
|
|
EP3331905B1
(en)
|
2015-08-06 |
2022-10-05 |
Dana-Farber Cancer Institute, Inc. |
Targeted protein degradation to attenuate adoptive t-cell therapy associated adverse inflammatory responses
|
|
US9580727B1
(en)
|
2015-08-07 |
2017-02-28 |
Caribou Biosciences, Inc. |
Compositions and methods of engineered CRISPR-Cas9 systems using split-nexus Cas9-associated polynucleotides
|
|
CN104962523B
(zh)
|
2015-08-07 |
2018-05-25 |
苏州大学 |
一种测定非同源末端连接修复活性的方法
|
|
AU2016305490B2
(en)
|
2015-08-07 |
2022-07-14 |
Commonwealth Scientific And Industrial Research Organisation |
Method for producing an animal comprising a germline genetic modification
|
|
JP2018522907A
(ja)
|
2015-08-11 |
2018-08-16 |
セレクティスCellectis |
Cd38抗原を標的とするためおよびcd38遺伝子を不活化するために操作された、免疫療法用の細胞
|
|
JP2018527920A
(ja)
|
2015-08-14 |
2018-09-27 |
インスティテュート・オブ・ジェネティクス・アンド・ディヴェロプメンタル・バイオロジー、チャイニーズ・アカデミー・オブ・サイエンシズInstitute of Genetics and Developmental Biology, Chinese Academy of Sciences |
部位特異的ヌクレオチド置換によりグリホサート耐性イネを取得するための方法
|
|
CN105255937A
(zh)
|
2015-08-14 |
2016-01-20 |
西北农林科技大学 |
一种真核细胞III型启动子表达CRISPR sgRNA的方法及其应用
|
|
CA2995983A1
(en)
|
2015-08-19 |
2017-02-23 |
Arc Bio, Llc |
Capture of nucleic acids using a nucleic acid-guided nuclease-based system
|
|
CN105112519A
(zh)
|
2015-08-20 |
2015-12-02 |
郑州大学 |
一种基于crispr的大肠杆菌o157:h7菌株检测试剂盒及检测方法
|
|
US11339408B2
(en)
|
2015-08-20 |
2022-05-24 |
Applied Stemcell, Inc. |
Nuclease with enhanced efficiency of genome editing
|
|
CN105177126B
(zh)
|
2015-08-21 |
2018-12-04 |
东华大学 |
一种利用荧光pcr技术对小鼠的分型鉴定方法
|
|
ES2929110T3
(es)
|
2015-08-25 |
2022-11-24 |
Univ Duke |
Composiciones y métodos para mejorar la especificidad en ingeniería genética usando endonucleasas guiadas por ARN
|
|
CN106480083B
(zh)
|
2015-08-26 |
2021-12-14 |
中国科学院分子植物科学卓越创新中心 |
CRISPR/Cas9介导的大片段DNA拼接方法
|
|
US9512446B1
(en)
|
2015-08-28 |
2016-12-06 |
The General Hospital Corporation |
Engineered CRISPR-Cas9 nucleases
|
|
US9926546B2
(en)
|
2015-08-28 |
2018-03-27 |
The General Hospital Corporation |
Engineered CRISPR-Cas9 nucleases
|
|
HK1257676A1
(zh)
|
2015-08-28 |
2019-10-25 |
The General Hospital Corporation |
工程化 crispr-cas 9 核酸酶
|
|
WO2017040709A1
(en)
|
2015-08-31 |
2017-03-09 |
Caribou Biosciences, Inc. |
Directed nucleic acid repair
|
|
EP3344771A4
(en)
|
2015-08-31 |
2019-03-20 |
Agilent Technologies, Inc. |
COMPOUNDS AND METHODS FOR CRISPR / CAS-BASED GENOME EDITATION THROUGH HOMOLOGOUS RECOMBINATION
|
|
CN105087620B
(zh)
|
2015-08-31 |
2017-12-29 |
中国农业大学 |
一种过表达猪共刺激受体4‑1bb载体及其应用
|
|
AU2016316027B2
(en)
|
2015-09-01 |
2022-04-07 |
Dana-Farber Cancer Institute Inc. |
Systems and methods for selection of gRNA targeting strands for Cas9 localization
|
|
WO2017040813A2
(en)
|
2015-09-02 |
2017-03-09 |
University Of Massachusetts |
Detection of gene loci with crispr arrayed repeats and/or polychromatic single guide ribonucleic acids
|
|
US20180251789A1
(en)
|
2015-09-04 |
2018-09-06 |
Massachusetts Institute Of Technology |
Multilayer genetic safety kill circuits based on single cas9 protein and multiple engineered grna in mammalian cells
|
|
CN105400810B
(zh)
|
2015-09-06 |
2019-05-07 |
吉林大学 |
采用敲除技术建立低磷性佝偻病模型的方法
|
|
US11453864B2
(en)
|
2015-09-08 |
2022-09-27 |
University Of Massachusetts |
DNase H activity of Neisseria meningitidis Cas9
|
|
ES2938623T3
(es)
|
2015-09-09 |
2023-04-13 |
Univ Kobe Nat Univ Corp |
Método para convertir una secuencia del genoma de una bacteria gram-positiva mediante una conversión específica de una base de ácido nucleico de una secuencia de ADN seleccionada como diana y el complejo molecular utilizado en el mismo
|
|
US20190024098A1
(en)
|
2015-09-09 |
2019-01-24 |
National University Corporation Kobe University |
Method for modifying genome sequence that specifically converts nucleobase of targeted dna sequence, and molecular complex used in said method
|
|
WO2017044776A1
(en)
|
2015-09-10 |
2017-03-16 |
Texas Tech University System |
Single-guide rna (sgrna) with improved knockout efficiency
|
|
CN108291224A
(zh)
|
2015-09-10 |
2018-07-17 |
优美佳生物技术有限公司 |
用于治疗青光眼的方法和组合物
|
|
CN105274144A
(zh)
|
2015-09-14 |
2016-01-27 |
徐又佳 |
通过CRISPR/Cas9技术得到敲除铁调素基因斑马鱼的制备方法
|
|
US10301613B2
(en)
|
2015-09-15 |
2019-05-28 |
Arizona Board Of Regents On Behalf Of Arizona State University |
Targeted remodeling of prokaryotic genomes using CRISPR-nickases
|
|
US10109551B2
(en)
|
2015-09-15 |
2018-10-23 |
Intel Corporation |
Methods and apparatuses for determining a parameter of a die
|
|
CN105210981B
(zh)
|
2015-09-15 |
2018-09-28 |
中国科学院生物物理研究所 |
建立可应用于人类疾病研究的雪貂模型的方法及其应用
|
|
CN105112422B
(zh)
|
2015-09-16 |
2019-11-08 |
中山大学 |
基因miR408和UCL在培育高产水稻中的应用
|
|
US11261439B2
(en)
|
2015-09-18 |
2022-03-01 |
President And Fellows Of Harvard College |
Methods of making guide RNA
|
|
EP3353298B1
(en)
|
2015-09-21 |
2023-09-13 |
Arcturus Therapeutics, Inc. |
Allele selective gene editing and uses thereof
|
|
EP3352795B1
(en)
|
2015-09-21 |
2020-08-12 |
The Regents of The University of California |
Compositions and methods for target nucleic acid modification
|
|
CN105132427B
(zh)
|
2015-09-21 |
2019-01-08 |
新疆畜牧科学院生物技术研究所 |
一种以RNA介导的特异性敲除双基因获得基因编辑绵羊的方法及其专用sgRNA
|
|
MX391052B
(es)
|
2015-09-23 |
2025-03-21 |
Sangamo Therapeutics Inc |
Represores de htt y usos de estos.
|
|
US11268144B2
(en)
|
2015-09-24 |
2022-03-08 |
Sigma-Aldrich Co. Llc |
Methods and reagents for molecular proximity detection using RNA-guided nucleic acid binding proteins
|
|
WO2017053879A1
(en)
|
2015-09-24 |
2017-03-30 |
Editas Medicine, Inc. |
Use of exonucleases to improve crispr/cas-mediated genome editing
|
|
CA2998287A1
(en)
|
2015-09-24 |
2017-04-20 |
Crispr Therapeutics Ag |
Novel family of rna-programmable endonucleases and their uses in genome editing and other applications
|
|
KR101745863B1
(ko)
|
2015-09-25 |
2017-06-12 |
전남대학교산학협력단 |
Crispr/cas9 시스템을 이용한 프로히비틴2 유전자 제거용 시발체
|
|
EP3353309A4
(en)
|
2015-09-25 |
2019-04-10 |
Tarveda Therapeutics, Inc. |
COMPOSITIONS AND METHOD FOR GENERIC EDITING
|
|
WO2017053729A1
(en)
|
2015-09-25 |
2017-03-30 |
The Board Of Trustees Of The Leland Stanford Junior University |
Nuclease-mediated genome editing of primary cells and enrichment thereof
|
|
KR101795999B1
(ko)
|
2015-09-25 |
2017-11-09 |
전남대학교산학협력단 |
Crispr/cas9 시스템을 이용한 베타2-마이크로글로불린 유전자 제거용 시발체
|
|
EP3147363B1
(en)
|
2015-09-26 |
2019-10-16 |
B.R.A.I.N. Ag |
Activation of taste receptor genes in mammalian cells using crispr-cas-9
|
|
AU2016332345A1
(en)
|
2015-09-28 |
2018-04-12 |
Temple University - Of The Commonwealth System Of Higher Education |
Methods and compositions for RNA-guided treatment of HIV infection
|
|
WO2017058796A1
(en)
|
2015-09-29 |
2017-04-06 |
Agenovir Corporation |
Antiviral fusion proteins and genes
|
|
CN105177038B
(zh)
|
2015-09-29 |
2018-08-24 |
中国科学院遗传与发育生物学研究所 |
一种高效定点编辑植物基因组的CRISPR/Cas9系统
|
|
CA2999923A1
(en)
|
2015-09-29 |
2017-04-06 |
Agenovir Corporation |
Compositions and methods for latent viral transcription regulation
|
|
WO2017058791A1
(en)
|
2015-09-29 |
2017-04-06 |
Agenovir Corporation |
Compositions and methods for treatment of latent viral infections
|
|
JP2018532403A
(ja)
|
2015-09-29 |
2018-11-08 |
アジェノビア コーポレーション |
送達方法および組成物
|
|
CN105331627B
(zh)
|
2015-09-30 |
2019-04-02 |
华中农业大学 |
一种利用内源CRISPR-Cas系统进行原核生物基因组编辑的方法
|
|
WO2017059241A1
(en)
|
2015-10-02 |
2017-04-06 |
The United States Of America, As Represented By The Secretary, Department Of Health And Human Services |
Lentiviral protein delivery system for rna-guided genome editing
|
|
AU2016336452B2
(en)
|
2015-10-06 |
2022-10-06 |
The Children's Hospital Of Philadelphia |
Compositions and methods for treating fragile X syndrome and related syndromes
|
|
WO2017062754A1
(en)
|
2015-10-07 |
2017-04-13 |
New York University |
Compositions and methods for enhancing crispr activity by polq inhibition
|
|
WO2017062886A1
(en)
|
2015-10-08 |
2017-04-13 |
Cellink Corporation |
Battery interconnects
|
|
EP3359661B1
(en)
|
2015-10-08 |
2025-08-06 |
President and Fellows of Harvard College |
Multiplexed genome editing
|
|
AU2016334225B2
(en)
|
2015-10-09 |
2022-11-10 |
Monsanto Technology Llc |
Novel RNA-guided nucleases and uses thereof
|
|
CA3004713A1
(en)
|
2015-10-09 |
2017-04-13 |
The Children's Hospital Of Philadelphia |
Compositions and methods for treating huntington's disease and related disorders
|
|
DK4144844T3
(da)
|
2015-10-12 |
2025-11-24 |
Dupont Us Holding Llc |
Beskyttede dna-templates til genmodificering og øget homolog rekombination i celler og fremgangsmåder til anvendelse deraf
|
|
US11970710B2
(en)
|
2015-10-13 |
2024-04-30 |
Duke University |
Genome engineering with Type I CRISPR systems in eukaryotic cells
|
|
CN108367081A
(zh)
|
2015-10-14 |
2018-08-03 |
生命技术公司 |
核糖核蛋白转染剂
|
|
CN105400779A
(zh)
|
2015-10-15 |
2016-03-16 |
芜湖医诺生物技术有限公司 |
嗜热链球菌CRISPR-Cas9系统识别的人CCR5基因的靶序列和sgRNA及其应用
|
|
AU2016337408B2
(en)
|
2015-10-16 |
2022-11-03 |
Astrazeneca Ab |
Inducible modification of a cell genome
|
|
FR3042506B1
(fr)
|
2015-10-16 |
2018-11-30 |
IFP Energies Nouvelles |
Outil genetique de transformation de bacteries clostridium
|
|
EP3362461B1
(en)
|
2015-10-16 |
2022-03-16 |
Modernatx, Inc. |
Mrna cap analogs with modified phosphate linkage
|
|
CA3001130A1
(en)
|
2015-10-16 |
2017-04-20 |
Temple University - Of The Commonwealth System Of Higher Education |
Methods and compositions utilizing cpf1 for rna-guided gene editing
|
|
CN105331607A
(zh)
|
2015-10-19 |
2016-02-17 |
芜湖医诺生物技术有限公司 |
嗜热链球菌CRISPR-Cas9系统识别的人CCR5基因的靶序列和sgRNA及其应用
|
|
WO2017070169A1
(en)
|
2015-10-19 |
2017-04-27 |
The Methodist Hospital |
Crispr-cas9 delivery to hard-to-transfect cells via membrane deformation
|
|
WO2017068077A1
(en)
|
2015-10-20 |
2017-04-27 |
Institut National De La Sante Et De La Recherche Medicale (Inserm) |
Methods and products for genetic engineering
|
|
CN108138156A
(zh)
|
2015-10-20 |
2018-06-08 |
先锋国际良种公司 |
用于无标记基因组修饰的方法和组合物
|
|
ES3036774T3
(en)
|
2015-10-20 |
2025-09-24 |
Inst Nat Sante Rech Med |
Methods and products for genetic engineering
|
|
CN105331609A
(zh)
|
2015-10-20 |
2016-02-17 |
芜湖医诺生物技术有限公司 |
脑膜炎双球菌CRISPR-Cas9系统识别的人CCR5基因的靶序列和sgRNA及其应用
|
|
CN105316337A
(zh)
|
2015-10-20 |
2016-02-10 |
芜湖医诺生物技术有限公司 |
嗜热链球菌CRISPR-Cas9系统识别的人CXCR4基因的靶序列和sgRNA及其应用
|
|
CN105331608A
(zh)
|
2015-10-20 |
2016-02-17 |
芜湖医诺生物技术有限公司 |
脑膜炎双球菌CRISPR-Cas9系统识别的人CXCR4基因的靶序列和sgRNA及其应用
|
|
CN105316324A
(zh)
|
2015-10-20 |
2016-02-10 |
芜湖医诺生物技术有限公司 |
嗜热链球菌CRISPR-Cas9系统识别的人CXCR4基因的靶序列和sgRNA及其应用
|
|
CA3001351A1
(en)
|
2015-10-21 |
2017-04-27 |
Editas Medicine, Inc. |
Crispr/cas-related methods and compositions for treating hepatitis b virus
|
|
EP3365441A1
(en)
|
2015-10-22 |
2018-08-29 |
The Broad Institute Inc. |
Type vi-b crispr enzymes and systems
|
|
CN105219799A
(zh)
|
2015-10-22 |
2016-01-06 |
天津吉诺沃生物科技有限公司 |
一种基于CRISPR/Cas系统的多年生黑麦草的育种方法
|
|
CA3002827A1
(en)
|
2015-10-23 |
2017-04-27 |
President And Fellows Of Harvard College |
Nucleobase editors and uses thereof
|
|
US20170112773A1
(en)
|
2015-10-23 |
2017-04-27 |
Board Of Regents, The University Of Texas System |
Plasma membrane vesicles comprising functional transmembrane proteins
|
|
EP3159407A1
(en)
|
2015-10-23 |
2017-04-26 |
Silence Therapeutics (London) Ltd |
Guide rnas, methods and uses
|
|
DK3350327T3
(en)
|
2015-10-23 |
2019-01-21 |
Caribou Biosciences Inc |
CONSTRUCTED CRISPR CLASS-2-NUCLEIC ACID TARGETING-NUCLEIC ACID
|
|
US9988637B2
(en)
|
2015-10-26 |
2018-06-05 |
National Tsing Hua Univeristy |
Cas9 plasmid, genome editing system and method of Escherichia coli
|
|
TW201715041A
(zh)
|
2015-10-26 |
2017-05-01 |
國立清華大學 |
細菌基因編輯方法
|
|
AU2016344135A1
(en)
|
2015-10-27 |
2018-06-14 |
Board Of Regents, The University Of Texas System |
Engineering of humanized car T-cells and platelets by genetic complementation
|
|
US10280411B2
(en)
|
2015-10-27 |
2019-05-07 |
Pacific Biosciences of California, In.c |
Methods, systems, and reagents for direct RNA sequencing
|
|
AU2016344609B2
(en)
|
2015-10-28 |
2022-05-12 |
Vertex Pharmaceuticals Incorporated |
Materials and methods for treatment of duchenne muscular dystrophy
|
|
US20180230489A1
(en)
|
2015-10-28 |
2018-08-16 |
Voyager Therapeutics, Inc. |
Regulatable expression using adeno-associated virus (aav)
|
|
KR102766526B1
(ko)
|
2015-10-28 |
2025-02-13 |
상가모 테라퓨틱스, 인코포레이티드 |
간-특이적 작제물인, 인자 viii 발현 카세트 및 이의 사용 방법
|
|
AU2016343991B2
(en)
|
2015-10-30 |
2022-12-01 |
Editas Medicine, Inc. |
CRISPR/CAS-related methods and compositions for treating herpes simplex virus
|
|
US11111508B2
(en)
|
2015-10-30 |
2021-09-07 |
Brandeis University |
Modified CAS9 compositions and methods of use
|
|
CN105238806B
(zh)
|
2015-11-02 |
2018-11-27 |
中国科学院天津工业生物技术研究所 |
一种用于微生物的CRISPR/Cas9基因编辑载体的构建及其应用
|
|
CN105316327B
(zh)
|
2015-11-03 |
2019-01-29 |
中国农业科学院作物科学研究所 |
小麦TaAGO4a基因CRISPR/Cas9载体及其应用
|
|
SG11201803144WA
(en)
|
2015-11-04 |
2018-05-30 |
Fate Therapeutics Inc |
Genomic engineering of pluripotent cells
|
|
EA201891092A1
(ru)
|
2015-11-04 |
2018-10-31 |
Дзе Трастиз Оф Дзе Юниверсити Оф Пенсильвания |
Способы и композиции для редактирования генов в гемопоэтических стволовых клетках
|
|
WO2017079428A1
(en)
|
2015-11-04 |
2017-05-11 |
President And Fellows Of Harvard College |
Site specific germline modification
|
|
AU2016348782A1
(en)
|
2015-11-05 |
2018-05-31 |
Cellectis |
Process of gene-editing of cells isolated from a subject suffering from a metabolic disease affecting the erythroid lineage, cells obtained by said process and uses thereof.
|
|
GB2544270A
(en)
|
2015-11-05 |
2017-05-17 |
Fundació Centre De Regulació Genòmica |
Nucleic acids, peptides and methods
|
|
WO2017078751A1
(en)
|
2015-11-06 |
2017-05-11 |
The Methodist Hospital |
Micoluidic cell deomailiy assay for enabling rapid and efficient kinase screening via the crispr-cas9 system
|
|
JP2018532415A
(ja)
|
2015-11-06 |
2018-11-08 |
ザ ジャクソン ラボラトリー |
大きなゲノムdnaノックインおよびその使用
|
|
WO2017081097A1
(en)
|
2015-11-09 |
2017-05-18 |
Ifom Fondazione Istituto Firc Di Oncologia Molecolare |
Crispr-cas sgrna library
|
|
EP3374501B1
(en)
|
2015-11-11 |
2023-07-12 |
Lonza Ltd |
Crispr-associated (cas) proteins with reduced immunogenicity
|
|
WO2017083722A1
(en)
|
2015-11-11 |
2017-05-18 |
Greenberg Kenneth P |
Crispr compositions and methods of using the same for gene therapy
|
|
JP2018537448A
(ja)
|
2015-11-12 |
2018-12-20 |
ファイザー・インコーポレイテッド |
CRISPR−Cas9を用いた組織特異的ゲノム操作
|
|
WO2017083766A1
(en)
|
2015-11-13 |
2017-05-18 |
Massachusetts Institute Of Technology |
High-throughput crispr-based library screening
|
|
KR101885901B1
(ko)
|
2015-11-13 |
2018-08-07 |
기초과학연구원 |
5' 말단의 인산기가 제거된 rna를 포함하는 리보핵산단백질 전달용 조성물
|
|
JP6929865B2
(ja)
|
2015-11-13 |
2021-09-01 |
タラ ムーア |
角膜ジストロフィーの治療方法
|
|
US20170191047A1
(en)
|
2015-11-13 |
2017-07-06 |
University Of Georgia Research Foundation, Inc. |
Adenosine-specific rnase and methods of use
|
|
JP7418957B2
(ja)
|
2015-11-16 |
2024-01-22 |
リサーチ インスティチュート アット ネイションワイド チルドレンズ ホスピタル |
タイチン系ミオパチー及び他のタイチノパチーの治療のための材料及び方法
|
|
CN106893739A
(zh)
|
2015-11-17 |
2017-06-27 |
香港中文大学 |
用于靶向基因操作的新方法和系统
|
|
CN105602987A
(zh)
|
2015-11-23 |
2016-05-25 |
深圳市默赛尔生物医学科技发展有限公司 |
一种高效的dc细胞xbp1基因敲除方法
|
|
JP2019500899A
(ja)
|
2015-11-23 |
2019-01-17 |
ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア |
CRISPR/Cas9の核送達を通じた細胞RNAの追跡と操作
|
|
US20170145438A1
(en)
|
2015-11-24 |
2017-05-25 |
University Of South Carolina |
Viral Vectors for Gene Editing
|
|
US10240145B2
(en)
|
2015-11-25 |
2019-03-26 |
The Board Of Trustees Of The Leland Stanford Junior University |
CRISPR/Cas-mediated genome editing to treat EGFR-mutant lung cancer
|
|
JP6500293B2
(ja)
|
2015-11-25 |
2019-04-17 |
国立大学法人群馬大学 |
Dnaメチル化編集用キットおよびdnaメチル化編集方法
|
|
US20180346940A1
(en)
|
2015-11-27 |
2018-12-06 |
The Regents Of The University Of California |
Compositions and methods for the production of hydrocarbons, hydrogen and carbon monoxide using engineered azotobacter strains
|
|
CN105505979A
(zh)
|
2015-11-28 |
2016-04-20 |
湖北大学 |
一种以CRISPR/Cas9基因编辑技术打靶Badh2基因获得香稻品系的方法
|
|
CN106811479B
(zh)
|
2015-11-30 |
2019-10-25 |
中国农业科学院作物科学研究所 |
利用CRISPR/Cas9系统定点修饰ALS基因获得抗除草剂水稻的系统及其应用
|
|
WO2017095111A1
(ko)
|
2015-11-30 |
2017-06-08 |
기초과학연구원 |
F. novicida 유래 Cas9을 포함하는 유전체 교정용 조성물
|
|
CN105296518A
(zh)
|
2015-12-01 |
2016-02-03 |
中国农业大学 |
一种用于CRISPR/Cas9技术的同源臂载体构建方法
|
|
RU2634395C1
(ru)
|
2015-12-01 |
2017-10-26 |
Федеральное государственное автономное образовательное учреждение высшего профессионального образования "Балтийский Федеральный Университет имени Иммануила Канта" (БФУ им. И. Канта) |
Генетическая конструкция на основе системы редактирования генома crispr/cas9, кодирующая нуклеазу cas9, специфически импортируемую в митохондрии клеток человека
|
|
US11085057B2
(en)
|
2015-12-02 |
2021-08-10 |
The Regents Of The University Of California |
Compositions and methods for modifying a target nucleic acid
|
|
MX2018006814A
(es)
|
2015-12-02 |
2019-08-05 |
Ceres Inc |
Metodos para la modificacion genetica de plantas.
|
|
WO2017093370A1
(en)
|
2015-12-03 |
2017-06-08 |
Technische Universität München |
T-cell specific genome editing
|
|
SG11201804373VA
(en)
|
2015-12-04 |
2018-06-28 |
Novartis Ag |
Compositions and methods for immunooncology
|
|
CN105779449B
(zh)
|
2015-12-04 |
2018-11-27 |
新疆农业大学 |
一种棉花启动子GbU6-5PS及应用
|
|
CN105779448B
(zh)
|
2015-12-04 |
2018-11-27 |
新疆农业大学 |
一种棉花启动子GbU6-7PS及应用
|
|
CN106845151B
(zh)
|
2015-12-07 |
2019-03-26 |
中国农业大学 |
CRISPR-Cas9系统sgRNA作用靶点的筛选方法及装置
|
|
CN105462968B
(zh)
|
2015-12-07 |
2018-10-16 |
北京信生元生物医学科技有限公司 |
一种靶向apoCⅢ的CRISPR-Cas9系统及其应用
|
|
RU2018124657A
(ru)
|
2015-12-09 |
2020-01-09 |
Эксижн Биотерапевтикс, Инк. |
Способы редактирования генов и композиции для устранения риска активации вируса jc и пмл (прогрессирующая мультифокальная лейкоэнцефалопатия) во время иммуносупрессивной терапии
|
|
CN105463003A
(zh)
|
2015-12-11 |
2016-04-06 |
扬州大学 |
一种消除卡那霉素耐药基因活性的重组载体及其构建方法
|
|
DK3387134T3
(da)
|
2015-12-11 |
2020-12-21 |
Danisco Us Inc |
Fremgangsmåder og sammensætninger til øget nukleasemedieret genommodifikation og reducerede virkninger uden for målstedet
|
|
CN105296537A
(zh)
|
2015-12-12 |
2016-02-03 |
西南大学 |
一种基于睾丸内注射的基因定点编辑技术
|
|
CN105400773B
(zh)
|
2015-12-14 |
2018-06-26 |
同济大学 |
应用于大规模筛选癌症基因的CRISPR/Cas9富集测序方法
|
|
WO2017105350A1
(en)
|
2015-12-14 |
2017-06-22 |
Cellresearch Corporation Pte Ltd |
A method of generating a mammalian stem cell carrying a transgene, a mammalian stem cell generated by the method and pharmaceuticals uses of the mammalian stem cell
|
|
WO2017106616A1
(en)
|
2015-12-17 |
2017-06-22 |
The Regents Of The University Of Colorado, A Body Corporate |
Varicella zoster virus encoding regulatable cas9 nuclease
|
|
CN105463027A
(zh)
|
2015-12-17 |
2016-04-06 |
中国农业大学 |
一种高肌肉量及肥厚型心肌病模型克隆猪的制备方法
|
|
US10316295B2
(en)
|
2015-12-17 |
2019-06-11 |
The Penn State Research Foundation |
Paramyxovirus virus-like particles as protein delivery vehicles
|
|
NO343153B1
(en)
|
2015-12-17 |
2018-11-19 |
Hydra Systems As |
A method of assessing the integrity status of a barrier plug
|
|
WO2017106569A1
(en)
|
2015-12-18 |
2017-06-22 |
The Regents Of The University Of California |
Modified site-directed modifying polypeptides and methods of use thereof
|
|
WO2017106767A1
(en)
|
2015-12-18 |
2017-06-22 |
The Scripps Research Institute |
Production of unnatural nucleotides using a crispr/cas9 system
|
|
EP3392337B1
(en)
|
2015-12-18 |
2024-03-06 |
Japan Science and Technology Agency |
Genetic modification non-human organism, egg cells, fertilized eggs, and method for modifying target genes
|
|
EA201891212A1
(ru)
|
2015-12-18 |
2019-01-31 |
Сангамо Терапьютикс, Инк. |
Адресная дезорганизация клеточного рецептора гкгс
|
|
US11352631B2
(en)
|
2015-12-18 |
2022-06-07 |
Sangamo Therapeutics, Inc. |
Targeted disruption of the T cell receptor
|
|
US12110490B2
(en)
|
2015-12-18 |
2024-10-08 |
The Broad Institute, Inc. |
CRISPR enzymes and systems
|
|
KR102698595B1
(ko)
|
2015-12-18 |
2024-08-23 |
다니스코 유에스 인크. |
중합효소 ii(pol-ii) 기반의 가이드 rna 발현을 위한 방법 및 조성물
|
|
WO2017105991A1
(en)
|
2015-12-18 |
2017-06-22 |
Danisco Us Inc. |
Methods and compositions for t-rna based guide rna expression
|
|
US11542466B2
(en)
|
2015-12-22 |
2023-01-03 |
North Carolina State University |
Methods and compositions for delivery of CRISPR based antimicrobials
|
|
SG11201804398XA
(en)
|
2015-12-22 |
2018-07-30 |
Curevac Ag |
Method for producing rna molecule compositions
|
|
BR112018012894A2
(en)
|
2015-12-23 |
2018-12-04 |
Crispr Therapeutics Ag |
Materials and Methods for Treatment of Amyotrophic Lateral Sclerosis and / or Frontotemporal Lobular Degeneration
|
|
CN105543270A
(zh)
|
2015-12-24 |
2016-05-04 |
中国农业科学院作物科学研究所 |
双抗性CRISPR/Cas9载体及应用
|
|
CN105505976A
(zh)
|
2015-12-25 |
2016-04-20 |
安徽大学 |
一种维吉尼亚链霉菌ibl14产青霉素重组菌株的构建方法
|
|
CN105543266A
(zh)
|
2015-12-25 |
2016-05-04 |
安徽大学 |
一种维吉尼亚链霉菌IBL14中的CRISPR-Cas系统及应用其进行基因编辑的方法
|
|
KR102860636B1
(ko)
|
2015-12-28 |
2025-09-17 |
노파르티스 아게 |
혈색소병증의 치료를 위한 조성물 및 방법
|
|
CN108738326B
(zh)
|
2015-12-29 |
2022-05-06 |
孟山都技术公司 |
新型crispr相关转座酶及其用途
|
|
CN105441451B
(zh)
|
2015-12-31 |
2019-03-22 |
暨南大学 |
一种特异靶向人ABCB1基因的sgRNA导向序列及应用
|
|
CN105567735A
(zh)
|
2016-01-05 |
2016-05-11 |
华东师范大学 |
一种凝血因子基因突变的定点修复载体系统及方法
|
|
EP3400296A1
(en)
|
2016-01-08 |
2018-11-14 |
Novozymes A/S |
Genome editing in bacillus host cells
|
|
US11441146B2
(en)
|
2016-01-11 |
2022-09-13 |
Christiana Care Health Services, Inc. |
Compositions and methods for improving homogeneity of DNA generated using a CRISPR/Cas9 cleavage system
|
|
CN105647922A
(zh)
|
2016-01-11 |
2016-06-08 |
中国人民解放军疾病预防控制所 |
基于一种新gRNA序列的CRISPR-Cas9系统在制备乙肝治疗药物中的应用
|
|
US11427837B2
(en)
|
2016-01-12 |
2022-08-30 |
The Regents Of The University Of California |
Compositions and methods for enhanced genome editing
|
|
US12049625B2
(en)
|
2016-01-14 |
2024-07-30 |
The Brigham And Women's Hospital, Inc. |
Genome editing for treating glioblastoma
|
|
WO2017124100A1
(en)
|
2016-01-14 |
2017-07-20 |
Memphis Meats, Inc. |
Methods for extending the replicative capacity of somatic cells during an ex vivo cultivation process
|
|
WO2017124086A1
(en)
|
2016-01-15 |
2017-07-20 |
The Jackson Laboratory |
Genetically modified non-human mammals by multi-cycle electroporation of cas9 protein
|
|
CN105567738A
(zh)
|
2016-01-18 |
2016-05-11 |
南开大学 |
使用基因组编辑技术CRISPR-Cas9诱导CCR5Δ32缺失的方法
|
|
WO2017126987A1
(ru)
|
2016-01-18 |
2017-07-27 |
Анатолий Викторович ЗАЗУЛЯ |
Эритроциты для направленного транспорта лекарственного средства
|
|
CN105567734A
(zh)
|
2016-01-18 |
2016-05-11 |
丹弥优生物技术(湖北)有限公司 |
一种基因组dna序列精准编辑方法
|
|
SE540921C2
(en)
|
2016-01-20 |
2018-12-27 |
Apr Tech Ab |
Electrohydrodynamic control device
|
|
US10731153B2
(en)
|
2016-01-21 |
2020-08-04 |
Massachusetts Institute Of Technology |
Recombinases and target sequences
|
|
EP3405570A1
(en)
|
2016-01-22 |
2018-11-28 |
The Broad Institute, Inc. |
Crystal structure of crispr cpf1
|
|
US20190032057A1
(en)
|
2016-01-25 |
2019-01-31 |
Excision Biotherapeutics, Inc. |
Methods and compositions for rna-guided treatment of hiv infection
|
|
CN105543228A
(zh)
|
2016-01-25 |
2016-05-04 |
宁夏农林科学院 |
一种快速将水稻转化为香稻的方法
|
|
CN105567689B
(zh)
|
2016-01-25 |
2019-04-09 |
重庆威斯腾生物医药科技有限责任公司 |
CRISPR/Cas9靶向敲除人TCAB1基因及其特异性gRNA
|
|
EP3408392A4
(en)
|
2016-01-25 |
2019-08-14 |
Excision Biotherapeutics |
RNA-induced clearance of the human JC-virus and other polymorphs
|
|
EP3199632A1
(en)
|
2016-01-26 |
2017-08-02 |
ACIB GmbH |
Temperature-inducible crispr/cas system
|
|
CN105567688A
(zh)
|
2016-01-27 |
2016-05-11 |
武汉大学 |
一种可用于艾滋病基因治疗的CRISPR/SaCas9系统
|
|
WO2017132580A2
(en)
|
2016-01-29 |
2017-08-03 |
The Trustees Of Princeton University |
Split inteins with exceptional splicing activity
|
|
JP6800171B2
(ja)
|
2016-01-30 |
2020-12-16 |
株式会社ボナック |
人工単一ガイドrna及びその用途
|
|
CN105647968B
(zh)
|
2016-02-02 |
2019-07-23 |
浙江大学 |
一种CRISPR/Cas9工作效率快速测试系统及其应用
|
|
CN107022562B
(zh)
|
2016-02-02 |
2020-07-17 |
中国种子集团有限公司 |
利用CRISPR/Cas9系统对玉米基因定点突变的方法
|
|
CN105671083B
(zh)
|
2016-02-03 |
2017-09-29 |
安徽柯顿生物科技有限公司 |
PD‑1基因重组病毒质粒及构建、重组逆转录病毒Lenti‑PD‑1‑Puro及包装与应用
|
|
WO2017136794A1
(en)
|
2016-02-03 |
2017-08-10 |
Massachusetts Institute Of Technology |
Structure-guided chemical modification of guide rna and its applications
|
|
US11208652B2
(en)
|
2016-02-04 |
2021-12-28 |
President And Fellows Of Harvard College |
Mitochondrial genome editing and regulation
|
|
US20190038780A1
(en)
|
2016-02-05 |
2019-02-07 |
Regents Of The University Of Minnesota |
Vectors and system for modulating gene expression
|
|
US11746349B2
(en)
|
2016-02-09 |
2023-09-05 |
President And Fellows Of Harvard College |
DNA-guided gene editing and regulation
|
|
RU2016104674A
(ru)
|
2016-02-11 |
2017-08-16 |
Анатолий Викторович Зазуля |
Устройство модификации эритроцита с механизмом направленного транспорта лекарственного средства для функций генной терапии crispr/cas9
|
|
WO2017139505A2
(en)
|
2016-02-11 |
2017-08-17 |
The Regents Of The University Of California |
Methods and compositions for modifying a mutant dystrophin gene in a cell's genome
|
|
US9896696B2
(en)
|
2016-02-15 |
2018-02-20 |
Benson Hill Biosystems, Inc. |
Compositions and methods for modifying genomes
|
|
CN105647962A
(zh)
|
2016-02-15 |
2016-06-08 |
浙江大学 |
运用CRISPR-Cas9系统敲除水稻MIRNA393b茎环序列的基因编辑方法
|
|
JP7176737B2
(ja)
|
2016-02-15 |
2022-11-22 |
テンプル ユニバーシティー オブ ザ コモンウェルス システム オブ ハイヤー エデュケーション |
レトロウイルス核酸配列の切除
|
|
US11136597B2
(en)
|
2016-02-16 |
2021-10-05 |
Yale University |
Compositions for enhancing targeted gene editing and methods of use thereof
|
|
CN105594664B
(zh)
|
2016-02-16 |
2018-10-02 |
湖南师范大学 |
一种基因敲除选育stat1a基因缺失型斑马鱼的方法
|
|
CN105647969B
(zh)
|
2016-02-16 |
2020-12-15 |
湖南师范大学 |
一种基因敲除选育stat1a基因缺失型斑马鱼的方法
|
|
WO2017142923A1
(en)
|
2016-02-16 |
2017-08-24 |
Emendobio Inc. |
Compositions and methods for promoting homology directed repair mediated gene editing
|
|
CN105624187A
(zh)
|
2016-02-17 |
2016-06-01 |
天津大学 |
酿酒酵母基因组定点突变的方法
|
|
WO2017142999A2
(en)
|
2016-02-18 |
2017-08-24 |
President And Fellows Of Harvard College |
Methods and systems of molecular recording by crispr-cas system
|
|
EP3653709B1
(en)
|
2016-02-22 |
2020-12-09 |
Caribou Biosciences, Inc. |
Methods for modulating dna repair outcomes
|
|
US20170275665A1
(en)
|
2016-02-24 |
2017-09-28 |
Board Of Regents, The University Of Texas System |
Direct crispr spacer acquisition from rna by a reverse-transcriptase-cas1 fusion protein
|
|
CN105646719B
(zh)
|
2016-02-24 |
2019-12-20 |
无锡市妇幼保健院 |
一种高效定点转基因的工具及其应用
|
|
WO2017147278A1
(en)
|
2016-02-25 |
2017-08-31 |
The Children's Medical Center Corporation |
Customized class switch of immunoglobulin genes in lymphoma and hybridoma by crispr/cas9 technology
|
|
US20170247703A1
(en)
|
2016-02-25 |
2017-08-31 |
Agenovir Corporation |
Antiviral nuclease methods
|
|
EP3420077A4
(en)
|
2016-02-25 |
2019-12-25 |
Agenovir Corporation |
VIRAL AND ONCOVIRAL NUCLEASE TREATMENT
|
|
US20170246260A1
(en)
|
2016-02-25 |
2017-08-31 |
Agenovir Corporation |
Modified antiviral nuclease
|
|
CA3015665C
(en)
|
2016-02-26 |
2020-09-22 |
Lanzatech New Zealand Limited |
Crispr/cas systems for c1-fixing bacteria
|
|
WO2017151444A1
(en)
|
2016-02-29 |
2017-09-08 |
Agilent Technologies, Inc. |
Methods and compositions for blocking off-target nucleic acids from cleavage by crispr proteins
|
|
US11447768B2
(en)
|
2016-03-01 |
2022-09-20 |
University Of Florida Research Foundation, Incorporated |
Molecular cell diary system
|
|
CN105671070B
(zh)
|
2016-03-03 |
2019-03-19 |
江南大学 |
一种用于枯草芽孢杆菌基因组编辑的CRISPRCas9系统及其构建方法
|
|
IL291971B2
(en)
|
2016-03-04 |
2025-04-01 |
Editas Medicine Inc |
CRISPR–CPF1 related methods, compositions and components for cancer immunotherapy
|
|
CN105821040B
(zh)
|
2016-03-09 |
2018-12-14 |
李旭 |
联合免疫基因抑制高危型HPV表达的sgRNA、基因敲除载体及其应用
|
|
CN107177591A
(zh)
|
2016-03-09 |
2017-09-19 |
北京大学 |
利用CRISPR技术编辑CCR5基因的sgRNA序列及其用途
|
|
CN105821039B
(zh)
|
2016-03-09 |
2020-02-07 |
李旭 |
联合免疫基因抑制HBV复制的特异性sgRNA、表达载体及其应用
|
|
CN105861547A
(zh)
|
2016-03-10 |
2016-08-17 |
黄捷 |
身份证号码永久嵌入基因组的方法
|
|
EP3699280A3
(en)
|
2016-03-11 |
2020-11-18 |
Pioneer Hi-Bred International, Inc. |
Novel cas9 systems and methods of use
|
|
CN117821458A
(zh)
|
2016-03-14 |
2024-04-05 |
爱迪塔斯医药公司 |
用于治疗β-血红蛋白病的CRISPR/CAS相关方法和组合物
|
|
US20180112234A9
(en)
|
2016-03-14 |
2018-04-26 |
Intellia Therapeutics, Inc. |
Methods and compositions for gene editing
|
|
EP3430332B1
(en)
|
2016-03-15 |
2020-01-01 |
Carrier Corporation |
Refrigerated sales cabinet
|
|
WO2017160689A1
(en)
|
2016-03-15 |
2017-09-21 |
University Of Massachusetts |
Anti-crispr compounds and methods of use
|
|
EP3219799A1
(en)
|
2016-03-17 |
2017-09-20 |
IMBA-Institut für Molekulare Biotechnologie GmbH |
Conditional crispr sgrna expression
|
|
US20200291370A1
(en)
|
2016-03-18 |
2020-09-17 |
President And Fellows Of Harvard College |
Mutant Cas Proteins
|
|
WO2017165741A1
(en)
|
2016-03-24 |
2017-09-28 |
Karim Aftab S |
Reverse transcriptase dependent conversion of rna templates into dna
|
|
WO2017165862A1
(en)
|
2016-03-25 |
2017-09-28 |
Editas Medicine, Inc. |
Systems and methods for treating alpha 1-antitrypsin (a1at) deficiency
|
|
WO2017165826A1
(en)
|
2016-03-25 |
2017-09-28 |
Editas Medicine, Inc. |
Genome editing systems comprising repair-modulating enzyme molecules and methods of their use
|
|
WO2017172644A2
(en)
|
2016-03-28 |
2017-10-05 |
The Charles Stark Draper Laboratory, Inc. |
Bacteria identification and antibiotic susceptibility profiling device
|
|
CN106047803A
(zh)
|
2016-03-28 |
2016-10-26 |
青岛市胶州中心医院 |
CRISPR/Cas9靶向敲除兔BMP2基因的细胞模型及其应用
|
|
WO2017173004A1
(en)
|
2016-03-30 |
2017-10-05 |
Mikuni Takayasu |
A method for in vivo precise genome editing
|
|
WO2017167712A1
(en)
|
2016-03-30 |
2017-10-05 |
F. Hoffmann-La Roche Ag |
Improved sortase
|
|
FI3436077T3
(fi)
|
2016-03-30 |
2025-07-10 |
Intellia Therapeutics Inc |
Lipidinanopartikkeliformulaatioita crispr/cas-komponenteille
|
|
WO2017172860A1
(en)
|
2016-03-31 |
2017-10-05 |
President And Fellows Of Harvard College |
Methods and compositions for the single tube preparation of sequencing libraries using cas9
|
|
US20190093128A1
(en)
|
2016-03-31 |
2019-03-28 |
The Regents Of The University Of California |
Methods for genome editing in zygotes
|
|
CN106167525B
(zh)
|
2016-04-01 |
2019-03-19 |
北京康明百奥新药研发有限公司 |
筛选超低岩藻糖细胞系的方法和应用
|
|
US10301619B2
(en)
|
2016-04-01 |
2019-05-28 |
New England Biolabs, Inc. |
Compositions and methods relating to synthetic RNA polynucleotides created from synthetic DNA oligonucleotides
|
|
CN118185874A
(zh)
|
2016-04-04 |
2024-06-14 |
苏黎世联邦理工学院 |
一种重组哺乳动物b细胞
|
|
WO2017176529A1
(en)
|
2016-04-06 |
2017-10-12 |
Temple Univesity-Of The Commonwealth System Of Higher Education |
Compositions for eradicating flavivirus infections in subjects
|
|
CN105802980A
(zh)
|
2016-04-08 |
2016-07-27 |
北京大学 |
Gateway兼容性CRISPR/Cas9系统及其应用
|
|
CN106399306B
(zh)
|
2016-04-12 |
2019-11-05 |
西安交通大学第一附属医院 |
靶向人lncRNA-UCA1抑制膀胱癌的sgRNA、基因载体及其应用
|
|
EP3443081A4
(en)
|
2016-04-13 |
2019-10-30 |
Duke University |
CRISPR / CAS9-BASED REPRESSORS FOR IN VIVO SHUT-OFF OF GEN-TARGETS AND METHOD OF USE
|
|
EP4495235A3
(en)
|
2016-04-13 |
2025-05-21 |
Editas Medicine, Inc. |
Grna fusion molecules, gene editing systems, and methods of use thereof
|
|
US11236313B2
(en)
|
2016-04-13 |
2022-02-01 |
Editas Medicine, Inc. |
Cas9 fusion molecules, gene editing systems, and methods of use thereof
|
|
SG11201808920RA
(en)
|
2016-04-14 |
2018-11-29 |
Boco Silicon Valley Inc |
Genome editing of human neural stem cells using nucleases
|
|
US20190167814A1
(en)
|
2016-04-14 |
2019-06-06 |
Université de Lausanne |
Treatment And/Or Prevention Of DNA-Triplet Repeat Diseases Or Disorders
|
|
CN105821116A
(zh)
|
2016-04-15 |
2016-08-03 |
扬州大学 |
一种绵羊mstn基因定向敲除及其影响成肌分化的检测方法
|
|
US12065667B2
(en)
|
2016-04-16 |
2024-08-20 |
Ohio State Innovation Foundation |
Modified Cpf1 MRNA, modified guide RNA, and uses thereof
|
|
WO2017184334A1
(en)
|
2016-04-18 |
2017-10-26 |
The Board Of Regents Of The University Of Texas System |
Generation of genetically engineered animals by crispr/cas9 genome editing in spermatogonial stem cells
|
|
EP3445852A1
(en)
|
2016-04-18 |
2019-02-27 |
Ruprecht-Karls-Universität Heidelberg |
Means and methods for inactivating therapeutic dna in a cell
|
|
CN106086062A
(zh)
|
2016-04-19 |
2016-11-09 |
上海市农业科学院 |
一种获得番茄基因组定点敲除突变体的方法
|
|
CA3026110A1
(en)
|
2016-04-19 |
2017-11-02 |
The Broad Institute, Inc. |
Novel crispr enzymes and systems
|
|
US11286478B2
(en)
|
2016-04-19 |
2022-03-29 |
The Broad Institute, Inc. |
Cpf1 complexes with reduced indel activity
|
|
CN110382692A
(zh)
|
2016-04-19 |
2019-10-25 |
博德研究所 |
新型crispr酶以及系统
|
|
CN105886616B
(zh)
|
2016-04-20 |
2020-08-07 |
广东省农业科学院农业生物基因研究中心 |
一种用于猪基因编辑的高效特异性sgRNA识别位点引导序列及其筛选方法
|
|
EP3235908A1
(en)
|
2016-04-21 |
2017-10-25 |
Ecole Normale Superieure De Lyon |
Methods for selectively modulating the activity of distinct subtypes of cells
|
|
EP3235828A1
(en)
|
2016-04-21 |
2017-10-25 |
Genethon |
Stable pseudotyped lentiviral particles and uses thereof
|
|
CN107304435A
(zh)
|
2016-04-22 |
2017-10-31 |
中国科学院青岛生物能源与过程研究所 |
一种Cas9/RNA系统及其应用
|
|
CN105821075B
(zh)
|
2016-04-22 |
2017-09-12 |
湖南农业大学 |
一种茶树咖啡因合成酶CRISPR/Cas9基因组编辑载体的构建方法
|
|
CN105861552B
(zh)
|
2016-04-25 |
2019-10-11 |
西北农林科技大学 |
一种T7 RNA聚合酶介导的CRISPR/Cas9基因编辑系统的构建方法
|
|
WO2017189336A1
(en)
|
2016-04-25 |
2017-11-02 |
The Regents Of The University Of California |
Methods and compositions for genomic editing
|
|
CN107326046A
(zh)
|
2016-04-28 |
2017-11-07 |
上海邦耀生物科技有限公司 |
一种提高外源基因同源重组效率的方法
|
|
CN105886534A
(zh)
|
2016-04-29 |
2016-08-24 |
苏州溯源精微生物科技有限公司 |
一种抑制肿瘤转移的方法
|
|
CN105821049B
(zh)
|
2016-04-29 |
2019-06-04 |
中国农业大学 |
一种Fbxo40基因敲除猪的制备方法
|
|
US11608499B2
(en)
|
2016-04-29 |
2023-03-21 |
Basf Plant Science Company Gmbh |
Methods for modification of target nucleic acids
|
|
SG11201809468XA
(en)
|
2016-04-29 |
2018-11-29 |
Sarepta Therapeutics Inc |
Oligonucleotide analogues targeting human lmna
|
|
NZ748874A
(en)
|
2016-05-01 |
2025-08-29 |
Neemo Inc |
Harnessing heterologous and endogenous crispr-cas machineries for efficient markerless genome editing in clostridium
|
|
WO2017192544A1
(en)
|
2016-05-02 |
2017-11-09 |
Massachusetts Institute Of Technology |
AMPHIPHILIC NANOPARTICLES FOR CODELIVERY OF WATER-INSOLUBLE SMALL MOLECULES AND RNAi
|
|
WO2017191210A1
(en)
|
2016-05-04 |
2017-11-09 |
Novozymes A/S |
Genome editing by crispr-cas9 in filamentous fungal host cells
|
|
CN105950639A
(zh)
|
2016-05-04 |
2016-09-21 |
广州美格生物科技有限公司 |
金黄色葡萄球菌CRISPR/Cas9系统的制备及其在构建小鼠模型中的应用
|
|
EP3452101A2
(en)
|
2016-05-04 |
2019-03-13 |
CureVac AG |
Rna encoding a therapeutic protein
|
|
ES2957660T3
(es)
|
2016-05-05 |
2024-01-23 |
Univ Duke |
Composiciones relacionadas con crispr/cas para tratar la distrofia muscular de duchenne
|
|
WO2017190664A1
(zh)
|
2016-05-05 |
2017-11-09 |
苏州吉玛基因股份有限公司 |
化学合成的crRNA和修饰crRNA在CRISPR/Cpf1基因编辑系统中的应用
|
|
CN105907785B
(zh)
|
2016-05-05 |
2020-02-07 |
苏州吉玛基因股份有限公司 |
化学合成的crRNA用于CRISPR/Cpf1系统在基因编辑中的应用
|
|
CN106244591A
(zh)
|
2016-08-23 |
2016-12-21 |
苏州吉玛基因股份有限公司 |
修饰crRNA在CRISPR/Cpf1基因编辑系统中的应用
|
|
WO2017192172A1
(en)
|
2016-05-05 |
2017-11-09 |
Temple University - Of The Commonwealth System Of Higher Education |
Rna guided eradication of varicella zoster virus
|
|
CN105985985B
(zh)
|
2016-05-06 |
2019-12-31 |
苏州大学 |
Crispr技术编辑并用igf优化的异体间充质干细胞的制备方法及在治疗心梗中应用
|
|
JP6872560B2
(ja)
|
2016-05-06 |
2021-05-19 |
エム. ウルフ、トッド |
プログラム可能ヌクレアーゼのあるゲノム編集及びプログラム可能ヌクレアーゼのないゲノム編集のための改善された方法
|
|
WO2017196768A1
(en)
|
2016-05-09 |
2017-11-16 |
President And Fellows Of Harvard College |
Self-targeting guide rnas in crispr system
|
|
WO2017197038A1
(en)
|
2016-05-10 |
2017-11-16 |
United States Government As Represented By The Department Of Veterans Affairs |
Lentiviral delivery of crispr/cas constructs that cleave genes essential for hiv-1 infection and replication
|
|
CN105861554B
(zh)
|
2016-05-10 |
2020-01-31 |
华南农业大学 |
一种基于对Rbmy基因进行编辑来实现动物性别控制的方法和应用
|
|
CN107365786A
(zh)
|
2016-05-12 |
2017-11-21 |
中国科学院微生物研究所 |
一种将spacer序列克隆至CRISPR-Cas9系统中的方法及其应用
|
|
WO2017197238A1
(en)
|
2016-05-12 |
2017-11-16 |
President And Fellows Of Harvard College |
Aav split cas9 genome editing and transcriptional regulation
|
|
US20200325483A1
(en)
|
2016-05-12 |
2020-10-15 |
Brian P. Hanley |
Safe delivery of crispr and other gene therapies to large fractions of somatic cells in humans and animals
|
|
JP6916209B2
(ja)
|
2016-05-13 |
2021-08-11 |
フラッシュ セラピューティクス |
特に免疫応答に関与する細胞への、rnaの転移のためのウイルス粒子
|
|
KR101922989B1
(ko)
|
2016-05-13 |
2018-11-28 |
연세대학교 산학협력단 |
CRISPR/Retron 시스템을 이용한 유전체상의 치환 변이 생성과 추적 방법
|
|
CN105907758B
(zh)
|
2016-05-18 |
2020-06-05 |
世翱(上海)生物医药科技有限公司 |
CRISPR-Cas9引导序列及其引物、转基因表达载体及其构建方法
|
|
CN106011171B
(zh)
|
2016-05-18 |
2019-10-11 |
西北农林科技大学 |
一种利用CRISPR/Cas9技术基于SSA修复的基因无缝编辑方法
|
|
CN105838733A
(zh)
|
2016-05-18 |
2016-08-10 |
云南省农业科学院花卉研究所 |
Cas9 介导的香石竹基因编辑载体和应用
|
|
CN106446600B
(zh)
|
2016-05-20 |
2019-10-18 |
同济大学 |
一种基于CRISPR/Cas9的sgRNA的设计方法
|
|
EP3457840B1
(en)
|
2016-05-20 |
2024-04-10 |
Regeneron Pharmaceuticals, Inc. |
Methods for breaking immunological tolerance using multiple guide rnas
|
|
US20190201551A1
(en)
|
2016-05-23 |
2019-07-04 |
Washington University |
Pulmonary targeted cas9/crispr for in vivo editing of disease genes
|
|
WO2017205290A1
(en)
|
2016-05-23 |
2017-11-30 |
The Trustees Of Columbia University In The City Of New York |
Bypassing the pam requirement of the crispr-cas system
|
|
CN105950560B
(zh)
|
2016-05-24 |
2019-07-23 |
苏州系统医学研究所 |
人源化pd-l1肿瘤细胞系及具有该细胞系的动物模型与应用
|
|
GB201609216D0
(en)
|
2016-05-25 |
2016-07-06 |
Evox Therapeutics And Isis Innovation Ltd |
Exosomes comprising therapeutic polypeptides
|
|
CN106011167B
(zh)
|
2016-05-27 |
2019-11-01 |
上海交通大学 |
雄性不育基因OsDPW2的应用及水稻育性恢复的方法
|
|
WO2017207589A1
(en)
|
2016-06-01 |
2017-12-07 |
Kws Saat Se |
Hybrid nucleic acid sequences for genome engineering
|
|
WO2017208247A1
(en)
|
2016-06-02 |
2017-12-07 |
Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. |
Assay for the removal of methyl-cytosine residues from dna
|
|
IL295358B2
(en)
|
2016-06-02 |
2023-09-01 |
Sigma Aldrich Co Llc |
Use of programmable DNA-binding proteins to enhance targeted genome modification
|
|
US11140883B2
(en)
|
2016-06-03 |
2021-10-12 |
Auburn University |
Gene editing of reproductive hormones to sterilize aquatic animals
|
|
RU2018144877A
(ru)
|
2016-06-03 |
2020-07-09 |
Темпл Юниверсити - Оф Де Коммонвелт Систем Оф Хаер Эдьюкейшн |
Регуляция HIV-1 по механизму отрицательной обратной связи с помощью стратегии редактирования генов
|
|
US20190256844A1
(en)
|
2016-06-07 |
2019-08-22 |
Temple University - Of The Commonwealth System Of Higher Education |
Rna guided compositions for preventing and treating hepatitis b virus infections
|
|
CN106119275A
(zh)
|
2016-06-07 |
2016-11-16 |
湖北大学 |
基于CRISPR/Cas9技术将非糯性水稻株系改造成糯性株系的打靶载体和方法
|
|
US10767175B2
(en)
|
2016-06-08 |
2020-09-08 |
Agilent Technologies, Inc. |
High specificity genome editing using chemically modified guide RNAs
|
|
US11779657B2
(en)
|
2016-06-10 |
2023-10-10 |
City Of Hope |
Compositions and methods for mitochondrial genome editing
|
|
CN106086008B
(zh)
|
2016-06-10 |
2019-03-12 |
中国农业科学院植物保护研究所 |
烟粉虱MED隐种TRP基因的CRISPR/cas9系统及其应用
|
|
CN106434752A
(zh)
|
2016-06-14 |
2017-02-22 |
南通大学附属医院 |
敲除Wnt3a基因的过程及其验证方法
|
|
AU2017286122A1
(en)
|
2016-06-14 |
2018-11-22 |
Pioneer Hi-Bred International, Inc. |
Use of Cpf1 endonuclease for plant genome modifications
|
|
CN106167821A
(zh)
|
2016-06-16 |
2016-11-30 |
郑州大学 |
一种金黄色葡萄球菌crispr位点检测试剂盒及检测方法
|
|
CN105950633B
(zh)
|
2016-06-16 |
2019-05-03 |
复旦大学 |
基因OsARF4在控制水稻粒长和千粒重中的应用
|
|
CN106167808A
(zh)
|
2016-06-16 |
2016-11-30 |
郑州大学 |
一种基于CRISPR/Cas9技术消除mecA质粒的方法
|
|
CN105950626B
(zh)
|
2016-06-17 |
2018-09-28 |
新疆畜牧科学院生物技术研究所 |
基于CRISPR/Cas9获得不同毛色绵羊的方法及靶向ASIP基因的sgRNA
|
|
WO2017219033A1
(en)
|
2016-06-17 |
2017-12-21 |
Montana State University |
Bidirectional targeting for genome editing
|
|
US20190330603A1
(en)
|
2016-06-17 |
2019-10-31 |
Genesis Technologies Limited |
Crispr-cas system, materials and methods
|
|
JP7267013B2
(ja)
|
2016-06-17 |
2023-05-01 |
ザ・ブロード・インスティテュート・インコーポレイテッド |
Vi型crisprオルソログ及び系
|
|
EP3472325B1
(en)
|
2016-06-20 |
2024-04-03 |
Keygene N.V. |
Method for targeted dna alteration in plant cells
|
|
WO2017223107A1
(en)
|
2016-06-20 |
2017-12-28 |
Unity Biotechnology, Inc. |
Genome modifying enzyme therapy for diseases modulated by senescent cells
|
|
WO2017222773A1
(en)
|
2016-06-20 |
2017-12-28 |
Pioneer Hi-Bred International, Inc. |
Novel cas systems and methods of use
|
|
US20170362635A1
(en)
|
2016-06-20 |
2017-12-21 |
University Of Washington |
Muscle-specific crispr/cas9 editing of genes
|
|
CN106148370A
(zh)
|
2016-06-21 |
2016-11-23 |
苏州瑞奇生物医药科技有限公司 |
肥胖症大鼠动物模型和构建方法
|
|
JP2019522481A
(ja)
|
2016-06-22 |
2019-08-15 |
アイカーン スクール オブ メディシン アット マウント サイナイ |
自己切断リボザイムを利用したrnaのウイルス送達およびそのcrisprベースの適用
|
|
JP7074345B2
(ja)
|
2016-06-22 |
2022-05-24 |
プロキューアール セラピューティクス ツー ベスローテン フェンノートシャップ |
一本鎖rna編集オリゴヌクレオチド
|
|
CN105925608A
(zh)
|
2016-06-24 |
2016-09-07 |
广西壮族自治区水牛研究所 |
一种利用CRISPR-Cas9靶向敲除ALK6基因的方法
|
|
CN106047877B
(zh)
|
2016-06-24 |
2019-01-11 |
中山大学附属第一医院 |
一种靶向敲除FTO基因的sgRNA及CRISPR/Cas9慢病毒系统与应用
|
|
CN106119283A
(zh)
|
2016-06-24 |
2016-11-16 |
广西壮族自治区水牛研究所 |
一种利用CRISPR‑Cas9靶向敲除MSTN基因的方法
|
|
WO2018005873A1
(en)
|
2016-06-29 |
2018-01-04 |
The Broad Institute Inc. |
Crispr-cas systems having destabilization domain
|
|
CA3029121A1
(en)
|
2016-06-29 |
2018-01-04 |
Crispr Therapeutics Ag |
Compositions and methods for gene editing
|
|
CN106148286B
(zh)
|
2016-06-29 |
2019-10-29 |
牛刚 |
一种用于检测热原的细胞模型的构建方法和细胞模型及热原检测试剂盒
|
|
WO2018005691A1
(en)
|
2016-06-29 |
2018-01-04 |
The Regents Of The University Of California |
Efficient genetic screening method
|
|
US10927383B2
(en)
|
2016-06-30 |
2021-02-23 |
Ethris Gmbh |
Cas9 mRNAs
|
|
US10892034B2
(en)
|
2016-07-01 |
2021-01-12 |
Microsoft Technology Licensing, Llc |
Use of homology direct repair to record timing of a molecular event
|
|
US20180004537A1
(en)
|
2016-07-01 |
2018-01-04 |
Microsoft Technology Licensing, Llc |
Molecular State Machines
|
|
ES2817973T3
(es)
|
2016-07-01 |
2021-04-08 |
Microsoft Technology Licensing Llc |
Almacenamiento a través de la edición iterativa del ADN
|
|
AU2017293773A1
(en)
|
2016-07-05 |
2019-02-21 |
The Johns Hopkins University |
CRISPR/Cas9-based compositions and methods for treating retinal degenerations
|
|
CN106191057B
(zh)
|
2016-07-06 |
2018-12-25 |
中山大学 |
一种用于敲除人CYP2E1基因的sgRNA序列、CYP2E1基因缺失细胞株的构建方法及其应用
|
|
WO2018009520A1
(en)
|
2016-07-06 |
2018-01-11 |
Novozymes A/S |
Improving a microorganism by crispr-inhibition
|
|
CN106051058A
(zh)
|
2016-07-07 |
2016-10-26 |
上海格昆机电科技有限公司 |
用于航天贮箱和粒子治疗仪的旋转机架及其传动机构
|
|
CN107586777A
(zh)
|
2016-07-08 |
2018-01-16 |
上海吉倍生物技术有限公司 |
人PDCD1基因sgRNA的用途及其相关药物
|
|
WO2018009822A1
(en)
|
2016-07-08 |
2018-01-11 |
Ohio State Innovation Foundation |
Modified nucleic acids, hybrid guide rnas, and uses thereof
|
|
GB2552460A
(en)
|
2016-07-11 |
2018-01-31 |
Evox Therapeutics Ltd |
CPP-Mediated EV Loading
|
|
GB2552301A
(en)
|
2016-07-11 |
2018-01-24 |
Evox Therapeutics Ltd |
Metabolic drug loading of EVs
|
|
CN106047930B
(zh)
|
2016-07-12 |
2020-05-19 |
北京百奥赛图基因生物技术有限公司 |
一种PS1基因条件性敲除flox大鼠的制备方法
|
|
WO2018013821A1
(en)
|
2016-07-13 |
2018-01-18 |
Dsm Ip Assets B.V. |
A crispr-cas system for an algal host cell
|
|
JP2019524098A
(ja)
|
2016-07-15 |
2019-09-05 |
ソーク インスティテュート フォー バイオロジカル スタディーズ |
非分裂細胞のゲノム編集のための方法と組成物
|
|
WO2018013990A1
(en)
|
2016-07-15 |
2018-01-18 |
Zymergen Inc. |
Scarless dna assembly and genome editing using crispr/cpf1 and dna ligase
|
|
CN106191061B
(zh)
|
2016-07-18 |
2019-06-18 |
暨南大学 |
一种特异靶向人ABCG2基因的sgRNA导向序列及其应用
|
|
CN106191062B
(zh)
|
2016-07-18 |
2019-06-14 |
广东华南疫苗股份有限公司 |
一种tcr-/pd-1-双阴性t细胞及其构建方法
|
|
CN106190903B
(zh)
|
2016-07-18 |
2019-04-02 |
华中农业大学 |
鸭疫里氏杆菌Cas9基因缺失突变株及其应用
|
|
CN106434651B
(zh)
|
2016-07-19 |
2021-05-18 |
广西大学 |
根癌农杆菌和CRISPR-Cas9介导的基因定点插入失活方法及其应用
|
|
EP4275747A3
(en)
|
2016-07-19 |
2024-01-24 |
Duke University |
Therapeutic applications of cpf1-based genome editing
|
|
KR20230088522A
(ko)
|
2016-07-21 |
2023-06-19 |
맥스시티 인코포레이티드 |
게놈 dna를 변경하기 위한 방법 및 조성물
|
|
WO2018015444A1
(en)
|
2016-07-22 |
2018-01-25 |
Novozymes A/S |
Crispr-cas9 genome editing with multiple guide rnas in filamentous fungi
|
|
CN106191107B
(zh)
|
2016-07-22 |
2020-03-20 |
湖南农业大学 |
一种降低水稻籽粒落粒性的分子改良方法
|
|
CN106191064B
(zh)
|
2016-07-22 |
2019-06-07 |
中国农业大学 |
一种制备mc4r基因敲除猪的方法
|
|
WO2018022480A1
(en)
|
2016-07-25 |
2018-02-01 |
Mayo Foundation For Medical Education And Research |
Treating cancer
|
|
WO2018018979A1
(zh)
|
2016-07-26 |
2018-02-01 |
浙江大学 |
植物重组载体及无转基因成分的基因编辑植株的筛选方法
|
|
CN106222193B
(zh)
|
2016-07-26 |
2019-09-20 |
浙江大学 |
一种重组载体及无转基因基因编辑植株的筛选方法
|
|
WO2018022634A1
(en)
|
2016-07-26 |
2018-02-01 |
The General Hospital Corporation |
Variants of crispr from prevotella and francisella 1 (cpf1)
|
|
CN106191099A
(zh)
|
2016-07-27 |
2016-12-07 |
苏州泓迅生物科技有限公司 |
一种基于CRISPR‑Cas9系统的酿酒酵母基因组并行多重编辑载体及其应用
|
|
CN106086061A
(zh)
|
2016-07-27 |
2016-11-09 |
苏州泓迅生物科技有限公司 |
一种基于CRISPR‑Cas9系统的酿酒酵母基因组编辑载体及其应用
|
|
WO2018021878A1
(ko)
|
2016-07-28 |
2018-02-01 |
주식회사 비엠티 |
옥외 배관용 히팅재킷
|
|
GB201613135D0
(en)
|
2016-07-29 |
2016-09-14 |
Medical Res Council |
Genome editing
|
|
CN106191114B
(zh)
|
2016-07-29 |
2020-02-11 |
中国科学院重庆绿色智能技术研究院 |
利用CRISPR-Cas9系统敲除鱼类MC4R基因的育种方法
|
|
CN106434748A
(zh)
|
2016-07-29 |
2017-02-22 |
中国科学院重庆绿色智能技术研究院 |
一种热激诱导型 Cas9 酶转基因斑马鱼的研制及应用
|
|
CN106191124B
(zh)
|
2016-07-29 |
2019-10-11 |
中国科学院重庆绿色智能技术研究院 |
一种利用鱼卵保存液提高CRISPR-Cas9基因编辑和传代效率的鱼类育种方法
|
|
CN106191113B
(zh)
|
2016-07-29 |
2020-01-14 |
中国农业大学 |
一种mc3r基因敲除猪的制备方法
|
|
WO2018026723A1
(en)
|
2016-08-01 |
2018-02-08 |
University Of Pittsburgh - Of The Commonwealth System Of Higher Education |
Human induced pluripotent stem cells for high efficiency genetic engineering
|
|
CN106434688A
(zh)
|
2016-08-01 |
2017-02-22 |
云南纳博生物科技有限公司 |
一种水稻直立密穗dep1基因人工定点突变体及其应用
|
|
CN106011150A
(zh)
|
2016-08-01 |
2016-10-12 |
云南纳博生物科技有限公司 |
一种水稻穗粒数Gn1a基因人工定点突变体及其应用
|
|
US20190153430A1
(en)
|
2016-08-02 |
2019-05-23 |
Kyoto University |
Method for genome editing
|
|
CA3032822A1
(en)
|
2016-08-02 |
2018-02-08 |
Editas Medicine, Inc. |
Compositions and methods for treating cep290 associated disease
|
|
KR102827276B1
(ko)
|
2016-08-03 |
2025-07-01 |
프레지던트 앤드 펠로우즈 오브 하바드 칼리지 |
아데노신 핵염기 편집제 및 그의 용도
|
|
CN106282241A
(zh)
|
2016-08-05 |
2017-01-04 |
无锡市第二人民医院 |
通过CRISPR/Cas9得到敲除bmp2a基因的斑马鱼的方法
|
|
JP7201153B2
(ja)
|
2016-08-09 |
2023-01-10 |
プレジデント アンド フェローズ オブ ハーバード カレッジ |
プログラム可能cas9-リコンビナーゼ融合タンパク質およびその使用
|
|
KR101710026B1
(ko)
|
2016-08-10 |
2017-02-27 |
주식회사 무진메디 |
Cas9 단백질 및 가이드 RNA의 혼성체를 함유하는 나노 리포좀 전달체 조성물
|
|
CN106222203A
(zh)
|
2016-08-10 |
2016-12-14 |
云南纳博生物科技有限公司 |
利用CRISPR/Cas技术获得家蚕丝素重链基因突变体及突变方法和应用
|
|
CN106172238B
(zh)
|
2016-08-12 |
2019-01-22 |
中南大学 |
miR-124基因敲除小鼠动物模型的构建方法和应用
|
|
BR112019002771A2
(pt)
|
2016-08-12 |
2019-05-14 |
Oxitec Ltd |
polinucleotídeo de módulo de controle de união de doublesex, sistema de expressão de gene, plasmídeo vetor de expressão, inseto geneticamente engenheirado, métodos para produzir insetos geneticamente engenheirados, para cultivar seletivamente insetos macho geneticamente engenheirados, para reduzir uma população de inseto selvagem, para criar um mosquito aedes aegypti transgênico e para detectar a presença de uma molécula de dna, local alvo cromossômico de aedes aegypti, mosquito aedes aegypti geneticamente engenheirado, molécula de dna, e, kit de detecção de dna.
|
|
CN106222177B
(zh)
|
2016-08-13 |
2018-06-26 |
江苏集萃药康生物科技有限公司 |
一种靶向人STAT6的CRISPR-Cas9系统及其用于治疗过敏性疾病的应用
|
|
WO2018035250A1
(en)
|
2016-08-17 |
2018-02-22 |
The Broad Institute, Inc. |
Methods for identifying class 2 crispr-cas systems
|
|
US20210000091A1
(en)
|
2016-08-17 |
2021-01-07 |
The Regents Of The University Of California |
Split Trans-Complementing Gene-Drive System for Suppressing Aedes Aegypti Mosquitos
|
|
US11810649B2
(en)
|
2016-08-17 |
2023-11-07 |
The Broad Institute, Inc. |
Methods for identifying novel gene editing elements
|
|
CN109996880A
(zh)
|
2016-08-18 |
2019-07-09 |
加利福尼亚大学董事会 |
基于模块化aav递送系统的crispr-cas基因组工程
|
|
CA3034101A1
(en)
|
2016-08-19 |
2018-02-22 |
Bluebird Bio, Inc. |
Genome editing enhancers
|
|
KR20230155013A
(ko)
|
2016-08-20 |
2023-11-09 |
아벨리노 랩 유에스에이, 인크. |
단일 가이드 RNA, CRISPR/Cas9 시스템, 및 이의 사용방법
|
|
CN106191116B
(zh)
|
2016-08-22 |
2019-10-08 |
西北农林科技大学 |
基于CRISPR/Cas9的外源基因敲入整合系统及其建立方法和应用
|
|
CN106191071B
(zh)
|
2016-08-22 |
2018-09-04 |
广州资生生物科技有限公司 |
一种CRISPR-Cas9系统及其用于治疗乳腺癌疾病的应用
|
|
CN106086028B
(zh)
|
2016-08-23 |
2019-04-23 |
中国农业科学院作物科学研究所 |
一种通过基因组编辑提高水稻抗性淀粉含量的方法及其专用sgRNA
|
|
CN106244555A
(zh)
|
2016-08-23 |
2016-12-21 |
广州医科大学附属第三医院 |
一种提高基因打靶的效率的方法及β‑球蛋白基因位点的碱基原位修复方法
|
|
CN106244609A
(zh)
|
2016-08-24 |
2016-12-21 |
浙江理工大学 |
一种调节pi3k‑akt信号通路的非编码基因的筛选系统及筛选方法
|
|
SG10202007392SA
(en)
|
2016-08-24 |
2020-09-29 |
Sangamo Therapeutics Inc |
Engineered target specific nucleases
|
|
US11542509B2
(en)
|
2016-08-24 |
2023-01-03 |
President And Fellows Of Harvard College |
Incorporation of unnatural amino acids into proteins using base editing
|
|
KR101856345B1
(ko)
|
2016-08-24 |
2018-06-20 |
경상대학교산학협력단 |
CRISPR/Cas9 시스템을 이용하여 APOBEC3H 및 APOBEC3CH 이중-넉아웃 고양이를 제조하는 방법
|
|
CN106109417A
(zh)
|
2016-08-24 |
2016-11-16 |
李因传 |
一种肝细胞膜仿生脂质体药物载体、制作方法及其应用
|
|
CR20190098A
(es)
|
2016-08-24 |
2019-04-30 |
Sangamo Therapeutics Inc |
Regulación de la expresión génica usando nucleasas modificadas
|
|
CN106544357B
(zh)
|
2016-08-25 |
2018-08-21 |
湖南杂交水稻研究中心 |
一种培育镉低积累籼稻品种的方法
|
|
CN106350540A
(zh)
|
2016-08-26 |
2017-01-25 |
苏州系统医学研究所 |
一种由慢病毒介导的高效可诱导型CRISPR/Cas9基因敲除载体及其应用
|
|
CN107784200B
(zh)
|
2016-08-26 |
2020-11-06 |
深圳华大生命科学研究院 |
一种筛选新型CRISPR-Cas系统的方法和装置
|
|
CN106318973B
(zh)
|
2016-08-26 |
2019-09-13 |
深圳市第二人民医院 |
一种基于CRISPR-Cas9的基因调控装置及基因调控方法
|
|
CN106244557B
(zh)
|
2016-08-29 |
2019-10-25 |
中国农业科学院北京畜牧兽医研究所 |
定点突变ApoE基因与LDLR基因的方法
|
|
CN106399367A
(zh)
|
2016-08-31 |
2017-02-15 |
深圳市卫光生物制品股份有限公司 |
提高crispr介导的同源重组效率的方法
|
|
CN106480097A
(zh)
|
2016-10-13 |
2017-03-08 |
南京凯地生物科技有限公司 |
利用CRISPR/Cas9技术敲除人PD‑1基因构建可靶向MSLN新型CAR‑T细胞的方法及其应用
|
|
CN106399375A
(zh)
|
2016-08-31 |
2017-02-15 |
南京凯地生物科技有限公司 |
利用CRISPR/Cas9敲除人PD‑1基因构建靶向CD19CAR‑T细胞的方法
|
|
CN107794272B
(zh)
|
2016-09-06 |
2021-10-12 |
中国科学院上海营养与健康研究所 |
一种高特异性的crispr基因组编辑体系
|
|
CN106399377A
(zh)
|
2016-09-07 |
2017-02-15 |
同济大学 |
一种基于CRISPR/Cas9高通量技术筛选药物靶点基因的方法
|
|
WO2018049077A1
(en)
|
2016-09-07 |
2018-03-15 |
Flagship Pioneering, Inc. |
Methods and compositions for modulating gene expression
|
|
WO2018048827A1
(en)
|
2016-09-07 |
2018-03-15 |
Massachusetts Institute Of Technology |
Rna-guided endonuclease-based dna assembly
|
|
CN106367435B
(zh)
|
2016-09-07 |
2019-11-08 |
电子科技大学 |
一种水稻miRNA定向敲除的方法
|
|
CN106399311A
(zh)
|
2016-09-07 |
2017-02-15 |
同济大学 |
用于Chip‑seq全基因组结合谱的内源蛋白标记的方法
|
|
CN107574179B
(zh)
|
2016-09-09 |
2018-07-10 |
康码(上海)生物科技有限公司 |
一种为克鲁维酵母优化的CRISPR/Cas9高效基因编辑系统
|
|
WO2018049168A1
(en)
|
2016-09-09 |
2018-03-15 |
The Board Of Trustees Of The Leland Stanford Junior University |
High-throughput precision genome editing
|
|
WO2018051347A1
(en)
|
2016-09-14 |
2018-03-22 |
Yeda Research And Development Co. Ltd. |
Crisp-seq, an integrated method for massively parallel single cell rna-seq and crispr pooled screens
|
|
CN106318934B
(zh)
|
2016-09-21 |
2020-06-05 |
上海交通大学 |
胡萝卜β(1,2)木糖转移酶的基因全序列及用于转染双子叶植物的CRISPR/CAS9的质粒构建
|
|
CN106957858A
(zh)
|
2016-09-23 |
2017-07-18 |
西北农林科技大学 |
一种利用CRISPR/Cas9系统共同敲除绵羊MSTN、ASIP、BCO2基因的方法
|
|
US20180127786A1
(en)
|
2016-09-23 |
2018-05-10 |
Casebia Therapeutics Limited Liability Partnership |
Compositions and methods for gene editing
|
|
US20200199599A1
(en)
|
2016-09-23 |
2020-06-25 |
Dsm Ip Assets B.V. |
A guide-rna expression system for a host cell
|
|
US9580698B1
(en)
|
2016-09-23 |
2017-02-28 |
New England Biolabs, Inc. |
Mutant reverse transcriptase
|
|
WO2018062866A2
(en)
|
2016-09-28 |
2018-04-05 |
Cellivery Therapeutics, Inc. |
CELL-PERMEABLE (CP)-Cas9 RECOMBINANT PROTEIN AND USES THEREOF
|
|
CN107880132B
(zh)
|
2016-09-30 |
2022-06-17 |
北京大学 |
一种融合蛋白及使用其进行同源重组的方法
|
|
CN107881184B
(zh)
|
2016-09-30 |
2021-08-27 |
中国科学院分子植物科学卓越创新中心 |
一种基于Cpf1的DNA体外拼接方法
|
|
CN106480027A
(zh)
|
2016-09-30 |
2017-03-08 |
重庆高圣生物医药有限责任公司 |
CRISPR/Cas9 靶向敲除人PD‑1基因及其特异性gRNA
|
|
EP3532089A4
(en)
|
2016-09-30 |
2020-05-13 |
The Regents of The University of California |
RNA-GUIDED NUCLEIC ACID MODIFYING ENZYMES AND METHOD FOR USE THEREOF
|
|
KR20230170126A
(ko)
|
2016-09-30 |
2023-12-18 |
더 리젠츠 오브 더 유니버시티 오브 캘리포니아 |
Rna-가이드된 핵산 변형 효소 및 이의 사용 방법
|
|
US20200024610A1
(en)
|
2016-09-30 |
2020-01-23 |
Monsanto Technology Llc |
Method for selecting target sites for site-specific genome modification in plants
|
|
WO2018067546A1
(en)
|
2016-10-03 |
2018-04-12 |
President And Fellows Of Harvard College |
Delivery of therapeutic rnas via arrdc1-mediated microvesicles
|
|
US20190241899A1
(en)
|
2016-10-05 |
2019-08-08 |
President And Fellows Of Harvard College |
Methods of Crispr Mediated Genome Modulation in V. Natriegens
|
|
US10669539B2
(en)
|
2016-10-06 |
2020-06-02 |
Pioneer Biolabs, Llc |
Methods and compositions for generating CRISPR guide RNA libraries
|
|
CN110462034A
(zh)
|
2016-10-07 |
2019-11-15 |
综合Dna技术公司 |
化脓链球菌cas9突变基因和由其编码的多肽
|
|
CN106479985A
(zh)
|
2016-10-09 |
2017-03-08 |
上海吉玛制药技术有限公司 |
病毒介导的Cpf1蛋白在CRISPR/Cpf1基因编辑系统中的应用
|
|
IT201600102542A1
(it)
|
2016-10-12 |
2018-04-12 |
Univ Degli Studi Di Trento |
Plasmide e sistema lentivirale contenente un circuito autolimitante della Cas9 che ne incrementa la sicurezza.
|
|
CN106434663A
(zh)
|
2016-10-12 |
2017-02-22 |
遵义医学院 |
CRISPR/Cas9靶向敲除人ezrin基因增强子关键区的方法及其特异性gRNA
|
|
US20190365862A1
(en)
|
2016-10-12 |
2019-12-05 |
Temple University - Of The Commonwealth System Of Higher Education |
Combination therapies for eradicating flavivirus infections in subjects
|
|
KR20240007715A
(ko)
|
2016-10-14 |
2024-01-16 |
프레지던트 앤드 펠로우즈 오브 하바드 칼리지 |
핵염기 에디터의 aav 전달
|
|
WO2018071663A1
(en)
|
2016-10-14 |
2018-04-19 |
Emendobio Inc. |
Rna compositions for genome editing
|
|
CN106434782B
(zh)
|
2016-10-14 |
2020-01-10 |
南京工业大学 |
一种产顺式-4-羟脯氨酸的方法
|
|
KR102662249B1
(ko)
|
2016-10-14 |
2024-05-03 |
더 제너럴 하스피탈 코포레이션 |
후성적으로 조절되는 부위-특이적 뉴클레아제
|
|
US11840694B2
(en)
|
2016-10-17 |
2023-12-12 |
Nanyang Technological University |
Truncated CRISPR-Cas proteins for DNA targeting
|
|
US10640810B2
(en)
|
2016-10-19 |
2020-05-05 |
Drexel University |
Methods of specifically labeling nucleic acids using CRISPR/Cas
|
|
EP3532616A1
(en)
|
2016-10-28 |
2019-09-04 |
Editas Medicine, Inc. |
Crispr/cas-related methods and compositions for treating herpes simplex virus
|
|
WO2018081534A1
(en)
|
2016-10-28 |
2018-05-03 |
President And Fellows Of Harvard College |
Assay for exo-site binding molecules
|
|
US20180119141A1
(en)
|
2016-10-28 |
2018-05-03 |
Massachusetts Institute Of Technology |
Crispr/cas global regulator screening platform
|
|
WO2018081535A2
(en)
|
2016-10-28 |
2018-05-03 |
Massachusetts Institute Of Technology |
Dynamic genome engineering
|
|
US11795453B2
(en)
|
2016-10-31 |
2023-10-24 |
Emendobio, Inc. |
Compositions for genome editing
|
|
US20190198214A1
(en)
|
2016-10-31 |
2019-06-27 |
Eguchi High Frequency Co., Ltd. |
Reactor
|
|
EP3535396A1
(en)
|
2016-11-01 |
2019-09-11 |
Novartis AG |
Methods and compositions for enhancing gene editing
|
|
WO2018085288A1
(en)
|
2016-11-01 |
2018-05-11 |
President And Fellows Of Harvard College |
Inhibitors of rna guided nucleases and uses thereof
|
|
US11732258B2
(en)
|
2016-11-02 |
2023-08-22 |
President And Fellows Of Harvard College |
Engineered guide RNA sequences for in situ detection and sequencing
|
|
GB201618507D0
(en)
|
2016-11-02 |
2016-12-14 |
Stichting Voor De Technische Wetenschappen And Wageningen Univ |
Microbial genome editing
|
|
CA3042700A1
(en)
|
2016-11-07 |
2018-05-11 |
University Of Massachusetts |
Therapeutic targets for facioscapulohumeral muscular dystrophy
|
|
CN106544353A
(zh)
|
2016-11-08 |
2017-03-29 |
宁夏医科大学总医院 |
一种利用CRISPR‑Cas9清除鲍曼不动杆菌耐药性基因的方法
|
|
CN106755088A
(zh)
|
2016-11-11 |
2017-05-31 |
广东万海细胞生物科技有限公司 |
一种自体car‑t细胞制备方法及应用
|
|
EP3538561A4
(en)
|
2016-11-11 |
2020-10-21 |
The Regents of The University of California |
RNA-GUIDED VARIANT POLYPEPTIDES AND THEIR METHODS OF USE
|
|
CA3043774A1
(en)
|
2016-11-14 |
2018-05-17 |
Caixia Gao |
A method for base editing in plants
|
|
CN106566838B
(zh)
|
2016-11-14 |
2019-11-01 |
上海伯豪生物技术有限公司 |
一种基于CRISPR-Cas9技术的miR-126全长基因敲除试剂盒及其应用
|
|
CN106554969A
(zh)
|
2016-11-15 |
2017-04-05 |
陕西理工学院 |
基于抑菌杀菌的多靶点CRISPR/Cas9表达载体
|
|
JP7210029B2
(ja)
|
2016-11-16 |
2023-01-23 |
ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア |
CRISPR-Cas9の阻害因子
|
|
CN106754912B
(zh)
|
2016-11-16 |
2019-11-08 |
上海交通大学 |
一类定向清除肝细胞中HBVcccDNA的质粒及制剂
|
|
US20180282722A1
(en)
|
2016-11-21 |
2018-10-04 |
Massachusetts Institute Of Technology |
Chimeric DNA:RNA Guide for High Accuracy Cas9 Genome Editing
|
|
CN106480067A
(zh)
|
2016-11-21 |
2017-03-08 |
中国农业科学院烟草研究所 |
烟草NtNAC096基因控制烟草衰老的应用
|
|
JP2019535287A
(ja)
|
2016-11-22 |
2019-12-12 |
インテグレイテツド・デイー・エヌ・エイ・テクノロジーズ・インコーポレイテツド |
Crispr/cpf1システム及び方法
|
|
CA3044531A1
(en)
|
2016-11-28 |
2018-05-31 |
The Board Of Regents Of The University Of Texas System |
Prevention of muscular dystrophy by crispr/cpf1-mediated gene editing
|
|
CN106755091A
(zh)
|
2016-11-28 |
2017-05-31 |
中国人民解放军第三军医大学第附属医院 |
基因敲除载体,mh7a细胞nlrp1基因敲除方法
|
|
CN106480036B
(zh)
|
2016-11-30 |
2019-04-09 |
华南理工大学 |
一种具有启动子功能的dna片段及其应用
|
|
CN106834323A
(zh)
|
2016-12-01 |
2017-06-13 |
安徽大学 |
一种基于维吉尼亚链霉菌IBL14基因cas7‑5‑3的基因编辑方法
|
|
CN107043779B
(zh)
|
2016-12-01 |
2020-05-12 |
中国农业科学院作物科学研究所 |
一种CRISPR/nCas9介导的定点碱基替换在植物中的应用
|
|
US20200056206A1
(en)
|
2016-12-01 |
2020-02-20 |
UNIVERSITé LAVAL |
Crispr-based treatment of friedreich ataxia
|
|
US9816093B1
(en)
|
2016-12-06 |
2017-11-14 |
Caribou Biosciences, Inc. |
Engineered nucleic acid-targeting nucleic acids
|
|
CN106701830B
(zh)
|
2016-12-07 |
2020-01-03 |
湖南人文科技学院 |
一种敲除猪胚胎p66shc基因的方法
|
|
CN108165573B
(zh)
|
2016-12-07 |
2022-01-14 |
中国科学院分子植物科学卓越创新中心 |
叶绿体基因组编辑方法
|
|
US11192929B2
(en)
|
2016-12-08 |
2021-12-07 |
Regents Of The University Of Minnesota |
Site-specific DNA base editing using modified APOBEC enzymes
|
|
CN110291198B
(zh)
|
2016-12-08 |
2024-11-26 |
因特利亚治疗公司 |
经修饰的指导rna
|
|
CN106544351B
(zh)
|
2016-12-08 |
2019-09-10 |
江苏省农业科学院 |
CRISPR-Cas9体外敲除耐药基因mcr-1的方法及其专用细胞穿透肽
|
|
WO2018107103A1
(en)
|
2016-12-09 |
2018-06-14 |
The Broad Institute, Inc. |
Crispr-systems for modifying a trait of interest in a plant
|
|
WO2018107129A1
(en)
|
2016-12-09 |
2018-06-14 |
The Broad Institute, Inc. |
Crispr effector system based diagnostics
|
|
WO2018111947A1
(en)
|
2016-12-12 |
2018-06-21 |
Integrated Dna Technologies, Inc. |
Genome editing enhancement
|
|
US20190032131A1
(en)
|
2016-12-12 |
2019-01-31 |
Integrated Dna Technologies, Inc. |
Genome editing detection
|
|
CN107893074A
(zh)
|
2016-12-13 |
2018-04-10 |
广东赤萌医疗科技有限公司 |
一种用于敲除CXCR4基因的gRNA、表达载体、敲除系统、试剂盒
|
|
CN110312792B
(zh)
|
2016-12-14 |
2024-04-09 |
瓦赫宁根大学 |
热稳定的Cas9核酸酶
|
|
WO2018109101A1
(en)
|
2016-12-14 |
2018-06-21 |
Wageningen Universiteit |
Thermostable cas9 nucleases
|
|
KR101748575B1
(ko)
|
2016-12-16 |
2017-06-20 |
주식회사 엠젠플러스 |
Ins 유전자 녹아웃 당뇨병 또는 당뇨병 합병증 동물모델 및 이의 제조방법
|
|
WO2018112336A1
(en)
|
2016-12-16 |
2018-06-21 |
Ohio State Innovation Foundation |
Systems and methods for dna-guided rna cleavage
|
|
CN106755026A
(zh)
|
2016-12-18 |
2017-05-31 |
吉林大学 |
sgRNA表达载体的构建及牙釉质钙化不全模型的建立
|
|
US12385093B2
(en)
|
2016-12-18 |
2025-08-12 |
Selonterra, Inc. |
Use of APOE4 motif-mediated genes for diagnosis and treatment of alzheimer's disease
|
|
JP7376091B2
(ja)
|
2016-12-23 |
2023-11-08 |
エクソファーマ リミテッド |
微小胞およびエキソソームの精製または単離のための方法および組成物
|
|
US10745677B2
(en)
|
2016-12-23 |
2020-08-18 |
President And Fellows Of Harvard College |
Editing of CCR5 receptor gene to protect against HIV infection
|
|
JP7456605B2
(ja)
|
2016-12-23 |
2024-03-27 |
プレジデント アンド フェローズ オブ ハーバード カレッジ |
Pcsk9の遺伝子編集
|
|
CN106755424B
(zh)
|
2016-12-26 |
2020-11-06 |
郑州大学 |
一种基于crispr的大肠杆菌st131系菌株检测引物、试剂盒及检测方法
|
|
CN107354173A
(zh)
|
2016-12-26 |
2017-11-17 |
浙江省医学科学院 |
基于crispr技术和水动力尾静脉注射建立肝脏特异性敲除小鼠模型的方法
|
|
CN108243575B
(zh)
|
2016-12-27 |
2020-04-17 |
Bgt材料有限公司 |
聚合物印刷电路板的制造方法
|
|
CN106834347A
(zh)
|
2016-12-27 |
2017-06-13 |
安徽省农业科学院畜牧兽医研究所 |
一种山羊cdk2基因敲除载体及其构建方法
|
|
CN106755097A
(zh)
|
2016-12-27 |
2017-05-31 |
安徽省农业科学院畜牧兽医研究所 |
一种山羊tlr4基因敲除载体及其构建方法
|
|
CN106597260B
(zh)
|
2016-12-29 |
2020-04-03 |
合肥工业大学 |
基于连续小波分析和elm网络的模拟电路故障诊断方法
|
|
CN106834341B
(zh)
|
2016-12-30 |
2020-06-16 |
中国农业大学 |
一种基因定点突变载体及其构建方法和应用
|
|
CN106701763B
(zh)
|
2016-12-30 |
2019-07-19 |
重庆高圣生物医药有限责任公司 |
CRISPR/Cas9靶向敲除人乙肝病毒P基因及其特异性gRNA
|
|
CN106755077A
(zh)
|
2016-12-30 |
2017-05-31 |
华智水稻生物技术有限公司 |
利用crispr‑cas9技术对水稻cenh3基因定点突变的方法
|
|
CN106868008A
(zh)
|
2016-12-30 |
2017-06-20 |
重庆高圣生物医药有限责任公司 |
CRISPR/Cas9靶向敲除人Lin28A基因及其特异性gRNA
|
|
CN106701818B
(zh)
|
2017-01-09 |
2020-04-24 |
湖南杂交水稻研究中心 |
一种培育水稻普通核不育系的方法
|
|
CN107012164B
(zh)
|
2017-01-11 |
2023-03-03 |
电子科技大学 |
CRISPR/Cpf1植物基因组定向修饰功能单元、包含该功能单元的载体及其应用
|
|
US20190352634A1
(en)
|
2017-01-11 |
2019-11-21 |
Oxford University Innovation Limited |
Crispr rna
|
|
CN110234770A
(zh)
|
2017-01-17 |
2019-09-13 |
基础科学研究院 |
通过dna单链断裂识别碱基编辑脱靶位点的方法
|
|
CN106701823A
(zh)
|
2017-01-18 |
2017-05-24 |
上海交通大学 |
生产无岩藻糖单克隆抗体的cho细胞系建立及其应用
|
|
CN107058372A
(zh)
|
2017-01-18 |
2017-08-18 |
四川农业大学 |
一种应用于植物上的CRISPR/Cas9载体的构建方法
|
|
WO2018136396A2
(en)
|
2017-01-18 |
2018-07-26 |
Excision Biotherapeutics, Inc. |
Crisprs
|
|
CN106801056A
(zh)
|
2017-01-24 |
2017-06-06 |
中国科学院广州生物医药与健康研究院 |
一种sgRNA及其构建的慢病毒载体和应用
|
|
CA3052099A1
(en)
|
2017-01-30 |
2018-08-02 |
Mathias LABS |
Repair template linkage to endonucleases for genome engineering
|
|
TWI608100B
(zh)
|
2017-02-03 |
2017-12-11 |
國立清華大學 |
Cas9表達質體、大腸桿菌基因剪輯系統及其方法
|
|
US10465187B2
(en)
|
2017-02-06 |
2019-11-05 |
Trustees Of Boston University |
Integrated system for programmable DNA methylation
|
|
TW201839136A
(zh)
|
2017-02-06 |
2018-11-01 |
瑞士商諾華公司 |
治療血色素異常症之組合物及方法
|
|
CN118370844A
(zh)
|
2017-02-07 |
2024-07-23 |
加利福尼亚大学董事会 |
单倍体机能不全的基因疗法
|
|
US20190345501A1
(en)
|
2017-02-07 |
2019-11-14 |
Massachusetts Institute Of Technology |
Methods and compositions for rna-guided genetic circuits
|
|
WO2018148647A2
(en)
|
2017-02-10 |
2018-08-16 |
Lajoie Marc Joseph |
Genome editing reagents and their use
|
|
IT201700016321A1
(it)
|
2017-02-14 |
2018-08-14 |
Univ Degli Studi Di Trento |
Mutanti di cas9 ad alta specificita' e loro applicazioni.
|
|
US20200063127A1
(en)
|
2017-02-15 |
2020-02-27 |
Massachusetts Institute Of Technology |
Dna writers, molecular recorders and uses thereof
|
|
US12215329B2
(en)
|
2017-02-15 |
2025-02-04 |
Keygene N.V. |
Methods of targeted genetic alteration in plant cells
|
|
CN106957855B
(zh)
|
2017-02-16 |
2020-04-17 |
上海市农业科学院 |
使用CRISPR/Cas9技术靶向敲除水稻矮杆基因SD1的方法
|
|
US20190367924A1
(en)
|
2017-02-17 |
2019-12-05 |
Temple University - Of The Commonwealth System Of Higher Education |
Gene editing therapy for hiv infection via dual targeting of hiv genome and ccr5
|
|
AU2018222092A1
(en)
|
2017-02-20 |
2019-09-05 |
Suzhou Qi Biodesign Biotechnology Company Limited |
Genome editing system and method
|
|
US20200095579A1
(en)
|
2017-02-22 |
2020-03-26 |
Crispr Therapeutics Ag |
Materials and methods for treatment of merosin-deficient cogenital muscular dystrophy (mdcmd) and other laminin, alpha 2 (lama2) gene related conditions or disorders
|
|
EP3585900B1
(en)
|
2017-02-22 |
2022-12-21 |
CRISPR Therapeutics AG |
Materials and methods for treatment of spinocerebellar ataxia type 2 (sca2) and other spinocerebellar ataxia type 2 protein (atxn2) gene related conditions or disorders
|
|
WO2018154418A1
(en)
|
2017-02-22 |
2018-08-30 |
Crispr Therapeutics Ag |
Materials and methods for treatment of early onset parkinson's disease (park1) and other synuclein, alpha (snca) gene related conditions or disorders
|
|
EP3585895A1
(en)
|
2017-02-22 |
2020-01-01 |
CRISPR Therapeutics AG |
Compositions and methods for gene editing
|
|
JP7277052B2
(ja)
|
2017-02-22 |
2023-05-18 |
クリスパー セラピューティクス アーゲー |
プロタンパク質転換酵素サブチリシン/ケキシン9型(pcsk9)関連障害の処置のための組成物および方法
|
|
WO2018154439A1
(en)
|
2017-02-22 |
2018-08-30 |
Crispr Therapeutics Ag |
Materials and methods for treatment of spinocerebellar ataxia type 1 (sca1) and other spinocerebellar ataxia type 1 protein (atxn1) gene related conditions or disorders
|
|
US20190365929A1
(en)
|
2017-02-22 |
2019-12-05 |
Crispr Therapeutics Ag |
Materials and methods for treatment of dystrophic epidermolysis bullosa (deb) and other collagen type vii alpha 1 chain (col7a1) gene related conditions or disorders
|
|
WO2018156372A1
(en)
|
2017-02-22 |
2018-08-30 |
The Regents Of The University Of California |
Genetically modified non-human animals and products thereof
|
|
GB201702863D0
(en)
|
2017-02-22 |
2017-04-05 |
Evox Therapeutics Ltd |
Improved loading of EVs with therapeutic proteins
|
|
EP3585899A1
(en)
|
2017-02-22 |
2020-01-01 |
CRISPR Therapeutics AG |
Materials and methods for treatment of primary hyperoxaluria type 1 (ph1) and other alanine-glyoxylate aminotransferase (agxt) gene related conditions or disorders
|
|
WO2018156824A1
(en)
|
2017-02-23 |
2018-08-30 |
President And Fellows Of Harvard College |
Methods of genetic modification of a cell
|
|
CN106868031A
(zh)
|
2017-02-24 |
2017-06-20 |
北京大学 |
一种基于分级组装的多个sgRNA串联并行表达的克隆方法及应用
|
|
JP2020508685A
(ja)
|
2017-03-03 |
2020-03-26 |
ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア |
サプレッサーtRNA及びデアミナーゼによる変異のRNAターゲティング
|
|
WO2018161009A1
(en)
|
2017-03-03 |
2018-09-07 |
Yale University |
Aav-mediated direct in vivo crispr screen in glioblastoma
|
|
US11111492B2
(en)
|
2017-03-06 |
2021-09-07 |
Florida State University Research Foundation, Inc. |
Genome engineering methods using a cytosine-specific Cas9
|
|
US11898179B2
(en)
|
2017-03-09 |
2024-02-13 |
President And Fellows Of Harvard College |
Suppression of pain by gene editing
|
|
US12390514B2
(en)
|
2017-03-09 |
2025-08-19 |
President And Fellows Of Harvard College |
Cancer vaccine
|
|
WO2018165629A1
(en)
|
2017-03-10 |
2018-09-13 |
President And Fellows Of Harvard College |
Cytosine to guanine base editor
|
|
EP3595694A4
(en)
|
2017-03-14 |
2021-06-09 |
The Regents of The University of California |
Engineering crispr cas9 immune stealth
|
|
CN106978428A
(zh)
|
2017-03-15 |
2017-07-25 |
上海吐露港生物科技有限公司 |
一种Cas蛋白特异结合靶标DNA、调控靶标基因转录的方法及试剂盒
|
|
KR20190140918A
(ko)
|
2017-03-15 |
2019-12-20 |
더 브로드 인스티튜트, 인코퍼레이티드 |
바이러스 검출을 위한 crispr 이펙터 시스템 기반 진단
|
|
CN106906242A
(zh)
|
2017-03-16 |
2017-06-30 |
重庆高圣生物医药有限责任公司 |
一种提高CRIPSR/Cas9靶向敲除基因产生非同源性末端接合效率的方法
|
|
CA3057330A1
(en)
|
2017-03-21 |
2018-09-27 |
Anthony P. Shuber |
Treating cancer with cas endonuclease complexes
|
|
BR112019019655A2
(pt)
|
2017-03-23 |
2020-04-22 |
Harvard College |
editores de nucleobase que compreendem proteínas de ligação a dna programáveis por ácido nucleico
|
|
CN107012213A
(zh)
|
2017-03-24 |
2017-08-04 |
南开大学 |
结直肠癌的生物标记物
|
|
EP3985113A1
(en)
|
2017-03-28 |
2022-04-20 |
Locanabio, Inc. |
Crispr-associated (cas) protein
|
|
CN106947780A
(zh)
|
2017-03-28 |
2017-07-14 |
扬州大学 |
一种兔mstn基因的编辑方法
|
|
CN106906240A
(zh)
|
2017-03-29 |
2017-06-30 |
浙江大学 |
运用CRISPR‑Cas9系统敲除大麦VE合成通路中的关键基因HPT的方法
|
|
WO2018179578A1
(ja)
|
2017-03-30 |
2018-10-04 |
国立大学法人京都大学 |
ゲノム編集によるエクソンスキッピング誘導方法
|
|
CN108660161B
(zh)
|
2017-03-31 |
2023-05-09 |
中国科学院脑科学与智能技术卓越创新中心 |
基于CRISPR/Cas9技术的制备无嵌合基因敲除动物的方法
|
|
CN107058358B
(zh)
|
2017-04-01 |
2020-06-09 |
中国科学院微生物研究所 |
一种双spacer序列识别切割CRISPR-Cas9载体构建及其在疣孢菌中的应用
|
|
US9938288B1
(en)
|
2017-04-05 |
2018-04-10 |
President And Fellows Of Harvard College |
Macrocyclic compound and uses thereof
|
|
CN106967726B
(zh)
|
2017-04-05 |
2020-12-29 |
华南农业大学 |
一种创建亚洲栽培稻与非洲栽培稻种间杂种亲和系的方法和应用
|
|
CN107142282A
(zh)
|
2017-04-06 |
2017-09-08 |
中山大学 |
一种利用CRISPR/Cas9在哺乳动物细胞中实现大片段DNA定点整合的方法
|
|
CN107034229A
(zh)
|
2017-04-07 |
2017-08-11 |
江苏贝瑞利生物科技有限公司 |
一种植物中高效筛选CRISPR/CAS9基因编辑系统候选sgRNA系统及应用
|
|
ES2880366T3
(es)
|
2017-04-11 |
2021-11-24 |
Hoffmann La Roche |
Retrotranscriptasa mutante con un incremento en la estabilidad térmica así como productos, procedimientos y usos que involucran la misma
|
|
CN107058320B
(zh)
|
2017-04-12 |
2019-08-02 |
南开大学 |
Il7r基因缺失斑马鱼突变体的制备及其应用
|
|
AU2018251801B2
(en)
|
2017-04-12 |
2024-11-07 |
Massachusetts Institute Of Technology |
Novel type VI CRISPR orthologs and systems
|
|
CN106916852B
(zh)
|
2017-04-13 |
2020-12-04 |
上海科技大学 |
一种碱基编辑系统及其构建和应用方法
|
|
CN108728476A
(zh)
|
2017-04-14 |
2018-11-02 |
复旦大学 |
一种利用crispr系统产生多样性抗体文库的方法
|
|
CN107298701B
(zh)
|
2017-04-18 |
2020-10-30 |
上海大学 |
玉米转录因子ZmbZIP22及其应用
|
|
BR112019021977A2
(pt)
|
2017-04-20 |
2020-06-16 |
Egenesis, Inc. |
Métodos para a geração de animais geneticamente modificados
|
|
CN106957844A
(zh)
|
2017-04-20 |
2017-07-18 |
华侨大学 |
一种能有效敲除HTLV‑1病毒基因组的CRISPR/Cas9的gRNA序列
|
|
EP4481049A3
(en)
|
2017-04-21 |
2025-03-19 |
The General Hospital Corporation |
Variants of cpf1 (cas12a) with altered pam specificity
|
|
US11773409B2
(en)
|
2017-04-21 |
2023-10-03 |
The Board Of Trustees Of The Leland Stanford Junior University |
CRISPR/Cas 9-mediated integration of polynucleotides by sequential homologous recombination of AAV donor vectors
|
|
EP3615665B1
(en)
|
2017-04-24 |
2025-11-26 |
International N&H Denmark ApS |
Novel anti-crispr genes and proteins and methods of use
|
|
CN107043775B
(zh)
|
2017-04-24 |
2020-06-16 |
中国农业科学院生物技术研究所 |
一种能促进棉花侧根发育的sgRNA及其应用
|
|
CN206970581U
(zh)
|
2017-04-26 |
2018-02-06 |
重庆威斯腾生物医药科技有限责任公司 |
一种用于辅助CRISPR/cas9基因敲除的试剂盒
|
|
US20180312822A1
(en)
|
2017-04-26 |
2018-11-01 |
10X Genomics, Inc. |
Mmlv reverse transcriptase variants
|
|
WO2018197020A1
(en)
|
2017-04-27 |
2018-11-01 |
Novozymes A/S |
Genome editing by crispr-cas9 using short donor oligonucleotides
|
|
EP3619305A1
(en)
|
2017-05-03 |
2020-03-11 |
KWS SAAT SE & Co. KGaA |
Use of crispr-cas endonucleases for plant genome engineering
|
|
CN107012174A
(zh)
|
2017-05-04 |
2017-08-04 |
昆明理工大学 |
CRISPR/Cas9技术在获得家蚕锌指蛋白基因突变体中的应用
|
|
US12029760B2
(en)
|
2017-05-04 |
2024-07-09 |
The Trustees Of The University Of Pennsylvania |
Compositions and methods for gene editing in T cells using CRISPR/Cpf1
|
|
CN107254485A
(zh)
|
2017-05-08 |
2017-10-17 |
南京农业大学 |
一种能够快速构建植物基因定点敲除载体的新反应体系
|
|
CN110869507A
(zh)
|
2017-05-08 |
2020-03-06 |
旗舰先锋创新V股份有限公司 |
促进膜融合的组合物和其用途
|
|
WO2018208755A1
(en)
|
2017-05-09 |
2018-11-15 |
The Regents Of The University Of California |
Compositions and methods for tagging target proteins in proximity to a nucleotide sequence of interest
|
|
CN107129999A
(zh)
|
2017-05-09 |
2017-09-05 |
福建省农业科学院畜牧兽医研究所 |
利用稳转CRISPR/Cas9系统对病毒基因组进行靶向编辑的方法
|
|
WO2018209158A2
(en)
|
2017-05-10 |
2018-11-15 |
Editas Medicine, Inc. |
Crispr/rna-guided nuclease systems and methods
|
|
JP7398279B2
(ja)
|
2017-05-10 |
2023-12-14 |
ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア |
Crispr/cas9核送達による細胞rnaの狙いを定めた編集
|
|
CN107130000B
(zh)
|
2017-05-12 |
2019-12-17 |
浙江卫未生物医药科技有限公司 |
一种同时敲除KRAS基因和EGFR基因的CRISPR-Cas9系统及其应用
|
|
US11560566B2
(en)
|
2017-05-12 |
2023-01-24 |
President And Fellows Of Harvard College |
Aptazyme-embedded guide RNAs for use with CRISPR-Cas9 in genome editing and transcriptional activation
|
|
CN106957831B
(zh)
|
2017-05-16 |
2021-03-12 |
上海交通大学 |
一种Cas9核酸酶K918A及其用途
|
|
CN106987570A
(zh)
|
2017-05-16 |
2017-07-28 |
上海交通大学 |
一种Cas9核酸酶R780A及其用途
|
|
CN106947750B
(zh)
|
2017-05-16 |
2020-12-08 |
上海交通大学 |
一种Cas9核酸酶Q920P及其用途
|
|
CN106957830B
(zh)
|
2017-05-16 |
2020-12-25 |
上海交通大学 |
一种Cas9核酸酶ΔF916及其用途
|
|
WO2018213351A1
(en)
|
2017-05-16 |
2018-11-22 |
The Regents Of The University Of California |
Thermostable rna-guided endonucleases and methods of use thereof
|
|
CN107326042A
(zh)
|
2017-05-16 |
2017-11-07 |
上海交通大学 |
水稻tms10基因的定点敲除系统及其应用
|
|
CN106939303B
(zh)
|
2017-05-16 |
2021-02-23 |
上海交通大学 |
一种Cas9核酸酶R919P及其用途
|
|
CN107012250B
(zh)
|
2017-05-16 |
2021-01-29 |
上海交通大学 |
一种适用于CRISPR/Cas9系统的基因组DNA片段编辑精准度的分析方法及应用
|
|
CN106916820B
(zh)
|
2017-05-16 |
2019-09-27 |
吉林大学 |
能有效编辑猪ROSA26基因的sgRNA及其应用
|
|
CN106967697B
(zh)
|
2017-05-16 |
2021-03-26 |
上海交通大学 |
一种Cas9核酸酶G915F及其用途
|
|
EP3625340A4
(en)
|
2017-05-18 |
2021-02-24 |
Cargill, Incorporated |
GENOME EDITING SYSTEM
|
|
AU2018270088B2
(en)
|
2017-05-18 |
2024-05-16 |
Massachusetts Institute Of Technology |
Systems, methods, and compositions for targeted nucleic acid editing
|
|
EP3625342B1
(en)
|
2017-05-18 |
2022-08-24 |
The Broad Institute, Inc. |
Systems, methods, and compositions for targeted nucleic acid editing
|
|
EP3625359A4
(en)
|
2017-05-18 |
2021-03-03 |
Children's National Medical Center |
APTAMERIC AND NUCLEIC ACID PAYLOAD COMPOSITIONS AND METHODS OF USE
|
|
CN107236737A
(zh)
|
2017-05-19 |
2017-10-10 |
上海交通大学 |
特异靶向拟南芥ILK2基因的sgRNA序列及其应用
|
|
CN107043787B
(zh)
|
2017-05-19 |
2017-12-26 |
南京医科大学 |
一种基于CRISPR/Cas9获得MARF1定点突变小鼠模型的构建方法和应用
|
|
WO2018217852A1
(en)
|
2017-05-23 |
2018-11-29 |
Gettysburg College |
Crispr based tool for characterizing bacterial serovar diversity
|
|
CN107034188B
(zh)
|
2017-05-24 |
2018-07-24 |
中山大学附属口腔医院 |
一种靶向骨的外泌体载体、CRISPR/Cas9基因编辑系统及应用
|
|
JP2020521446A
(ja)
|
2017-05-25 |
2020-07-27 |
ザ ジェネラル ホスピタル コーポレイション |
二部塩基エディター(bbe)構造およびii型−c−cas9ジンクフィンガー編集
|
|
EP3630975B1
(en)
|
2017-05-26 |
2025-11-19 |
North Carolina State University |
Altered guide rnas for modulating cas9 activity and methods of use
|
|
CN107177625B
(zh)
|
2017-05-26 |
2021-05-25 |
中国农业科学院植物保护研究所 |
一种定点突变的人工载体系统及定点突变方法
|
|
CN107287245B
(zh)
|
2017-05-27 |
2020-03-17 |
南京农业大学 |
一种基于CRISPR/Cas9技术的Glrx1基因敲除动物模型的构建方法
|
|
EP3635103A1
(en)
|
2017-06-05 |
2020-04-15 |
Research Institute at Nationwide Children's Hospital |
Enhanced modified viral capsid proteins
|
|
CN107142272A
(zh)
|
2017-06-05 |
2017-09-08 |
南京金斯瑞生物科技有限公司 |
一种控制大肠杆菌中质粒复制的方法
|
|
WO2018226855A1
(en)
|
2017-06-06 |
2018-12-13 |
The General Hospital Corporation |
Engineered crispr-cas9 nucleases
|
|
CN107177595A
(zh)
|
2017-06-07 |
2017-09-19 |
浙江大学 |
用于猪CD163基因编辑的靶向sgRNA、修饰载体及其制备方法和应用
|
|
CN107119071A
(zh)
|
2017-06-07 |
2017-09-01 |
江苏三黍生物科技有限公司 |
一种降低植物直链淀粉含量的方法及应用
|
|
CN107034218A
(zh)
|
2017-06-07 |
2017-08-11 |
浙江大学 |
用于猪APN基因编辑的靶向sgRNA、修饰载体及其制备方法和应用
|
|
CN107236739A
(zh)
|
2017-06-12 |
2017-10-10 |
上海捷易生物科技有限公司 |
CRISPR/SaCas9特异性敲除人CXCR4基因的方法
|
|
CN106987757A
(zh)
|
2017-06-12 |
2017-07-28 |
苏州双金实业有限公司 |
一种耐腐蚀型奥氏体镍基合金
|
|
CN107083392B
(zh)
|
2017-06-13 |
2020-09-08 |
中国医学科学院病原生物学研究所 |
一种CRISPR/Cpf1基因编辑系统及其在分枝杆菌中的应用
|
|
CN107227352A
(zh)
|
2017-06-13 |
2017-10-03 |
西安医学院 |
基于eGFP的GPR120基因表达的检测方法及应用
|
|
CN107245502B
(zh)
|
2017-06-14 |
2020-11-03 |
中国科学院武汉病毒研究所 |
Cd2结合蛋白(cd2ap)和其相互作用蛋白
|
|
CN107312798B
(zh)
|
2017-06-16 |
2020-06-23 |
武汉大学 |
含特异靶向CCR5基因的gRNA序列的CRISPR/Cas9重组慢病毒载体及应用
|
|
CN107099850B
(zh)
|
2017-06-19 |
2018-05-04 |
东北农业大学 |
一种通过酶切基因组构建CRISPR/Cas9基因组敲除文库的方法
|
|
CN107266541B
(zh)
|
2017-06-20 |
2021-06-04 |
上海大学 |
玉米转录因子ZmbHLH167及其应用
|
|
CN107446951B
(zh)
|
2017-06-20 |
2021-01-08 |
温氏食品集团股份有限公司 |
一种通过CRISPR/Cas9系统快速筛选重组鸡痘病毒的方法及其应用
|
|
CN107058328A
(zh)
|
2017-06-22 |
2017-08-18 |
江苏三黍生物科技有限公司 |
一种提高植物直链淀粉含量的方法及应用
|
|
US10011849B1
(en)
|
2017-06-23 |
2018-07-03 |
Inscripta, Inc. |
Nucleic acid-guided nucleases
|
|
CN107227307A
(zh)
|
2017-06-23 |
2017-10-03 |
东北农业大学 |
一种特异靶向猪IRS1基因的sgRNA导向序列及其应用
|
|
CN107099533A
(zh)
|
2017-06-23 |
2017-08-29 |
东北农业大学 |
一种特异靶向猪IGFBP3基因的sgRNA导向序列及应用
|
|
CN107119053A
(zh)
|
2017-06-23 |
2017-09-01 |
东北农业大学 |
一种特异靶向猪MC4R基因的sgRNA导向序列及其应用
|
|
US9982279B1
(en)
|
2017-06-23 |
2018-05-29 |
Inscripta, Inc. |
Nucleic acid-guided nucleases
|
|
US20210093667A1
(en)
|
2017-06-26 |
2021-04-01 |
The Broad Institute, Inc. |
Crispr/cas-adenine deaminase based compositions, systems, and methods for targeted nucleic acid editing
|
|
US20200248169A1
(en)
|
2017-06-26 |
2020-08-06 |
The Broad Institute, Inc. |
Crispr/cas-cytidine deaminase based compositions, systems, and methods for targeted nucleic acid editing
|
|
CN107177631B
(zh)
|
2017-06-26 |
2020-11-24 |
中国农业大学 |
利用CRISPR-CAS9技术敲除NRK细胞Slc22a2基因的方法
|
|
CN107217075B
(zh)
|
2017-06-28 |
2021-07-02 |
西安交通大学医学院第一附属医院 |
一种构建epo基因敲除斑马鱼动物模型的方法及引物、质粒与制备方法
|
|
CN107356793A
(zh)
|
2017-07-01 |
2017-11-17 |
合肥东玖电气有限公司 |
一种防火电表箱
|
|
CN107312793A
(zh)
|
2017-07-05 |
2017-11-03 |
新疆农业科学院园艺作物研究所 |
Cas9介导的番茄基因编辑载体及其应用
|
|
CN107190006A
(zh)
|
2017-07-07 |
2017-09-22 |
南通大学附属医院 |
一种靶向IGF‑IR基因的sgRNA及其应用
|
|
WO2019010384A1
(en)
|
2017-07-07 |
2019-01-10 |
The Broad Institute, Inc. |
METHODS FOR DESIGNING GUIDE SEQUENCES FOR GUIDED NUCLEASES
|
|
CN107236741A
(zh)
|
2017-07-19 |
2017-10-10 |
广州医科大学附属第五医院 |
一种敲除野生型T细胞TCR alpha链的gRNA及方法
|
|
CN107400677B
(zh)
|
2017-07-19 |
2020-05-22 |
江南大学 |
一种基于CRISPR-Cas9系统的地衣芽孢杆菌基因组编辑载体及其制备方法
|
|
CN107354156B
(zh)
|
2017-07-19 |
2021-02-09 |
广州医科大学附属第五医院 |
一种敲除野生型T细胞TCR beta链的gRNA及方法
|
|
CN107190008A
(zh)
|
2017-07-19 |
2017-09-22 |
苏州吉赛基因测序科技有限公司 |
一种基于Crispr/cas9的捕获基因组目标序列的方法及其在高通量测序中的应用
|
|
CN107435069A
(zh)
|
2017-07-28 |
2017-12-05 |
新乡医学院 |
一种细胞系CRISPR/Cas9基因敲除的快速检测方法
|
|
CN107435051B
(zh)
|
2017-07-28 |
2020-06-02 |
新乡医学院 |
一种通过CRISPR/Cas9系统快速获得大片段缺失的细胞系基因敲除方法
|
|
JP2020534795A
(ja)
|
2017-07-28 |
2020-12-03 |
プレジデント アンド フェローズ オブ ハーバード カレッジ |
ファージによって支援される連続的進化(pace)を用いて塩基編集因子を進化させるための方法および組成物
|
|
CN107384922A
(zh)
|
2017-07-28 |
2017-11-24 |
重庆医科大学附属儿童医院 |
CRISPR/Cas9靶向敲除人CNE9基因及其特异性gRNA
|
|
CN107267515B
(zh)
|
2017-07-28 |
2020-08-25 |
重庆医科大学附属儿童医院 |
CRISPR/Cas9靶向敲除人CNE10基因及其特异性gRNA
|
|
CN107446954A
(zh)
|
2017-07-28 |
2017-12-08 |
新乡医学院 |
一种sd大鼠t细胞缺失遗传模型的制备方法
|
|
CN107418974A
(zh)
|
2017-07-28 |
2017-12-01 |
新乡医学院 |
一种利用单克隆细胞分选快速获得CRISPR/Cas9基因敲除稳定细胞株的方法
|
|
CN107217042B
(zh)
|
2017-07-31 |
2020-03-06 |
江苏东抗生物医药科技有限公司 |
一种生产无岩藻糖基化蛋白的基因工程细胞系及其建立方法
|
|
KR20200017479A
(ko)
|
2017-07-31 |
2020-02-18 |
시그마-알드리치 컴퍼니., 엘엘씨 |
Crispr/cas 활성제 시스템용 합성 유도 rna
|
|
CN107446922A
(zh)
|
2017-08-03 |
2017-12-08 |
无锡市第二人民医院 |
一种敲除人成骨细胞株中hepcidin基因的gRNA序列及其使用方法
|
|
CN107502618B
(zh)
|
2017-08-08 |
2021-03-12 |
中国科学院微生物研究所 |
可控载体消除方法及易用型CRISPR-Cas9工具
|
|
CN107312785B
(zh)
|
2017-08-09 |
2019-12-06 |
四川农业大学 |
OsKTN80b基因在降低水稻株高方面的应用
|
|
CN107365804B
(zh)
|
2017-08-13 |
2019-12-20 |
中国人民解放军疾病预防控制所 |
一种使用温和噬菌体载体包装CRISPR-Cas9系统的方法
|
|
CN107446923B
(zh)
|
2017-08-13 |
2019-12-31 |
中国人民解放军疾病预防控制所 |
rAAV8-CRISPR-SaCas9系统及在制备乙肝治疗药物中的应用
|
|
CN107384926B
(zh)
|
2017-08-13 |
2020-06-26 |
中国人民解放军疾病预防控制所 |
一种靶向清除细菌耐药性质粒的CRISPR-Cas9系统及应用
|
|
CN107815463A
(zh)
|
2017-08-15 |
2018-03-20 |
西南大学 |
CRISPR/Cas9技术介导miR167前体序列编辑体系的建立方法
|
|
CN107446924B
(zh)
|
2017-08-16 |
2020-01-14 |
中国科学院华南植物园 |
一种基于CRISPR-Cas9的猕猴桃基因AcPDS编辑载体及其构建方法和应用
|
|
CN108034656A
(zh)
|
2017-08-16 |
2018-05-15 |
四川省农业科学院生物技术核技术研究所 |
与水稻红褐色颖壳性状有关的sgRNA、CRISPR/Cas9载体、载体构建、应用
|
|
JP7224352B2
(ja)
|
2017-08-17 |
2023-02-17 |
イリアス バイオロジクス インコーポレイテッド |
標的特異的伝達のためのエクソソーム及びこれを製造及び伝達する方法
|
|
CN107384894B
(zh)
|
2017-08-21 |
2019-10-22 |
华南师范大学 |
功能化氧化石墨烯高效运载CRISPR/Cas9用于基因编辑的方法
|
|
CN107557393B
(zh)
|
2017-08-23 |
2020-05-08 |
中国科学院上海应用物理研究所 |
一种磁性纳米材料介导的CRISPR/Cas9 T细胞内递送系统及其制备方法和应用
|
|
CN107299114B
(zh)
|
2017-08-23 |
2021-08-27 |
中国科学院分子植物科学卓越创新中心 |
一种高效的酵母菌染色体融合方法
|
|
CN107312795A
(zh)
|
2017-08-24 |
2017-11-03 |
浙江省农业科学院 |
运用CRISPR/Cas9系统创制粉色果实番茄的基因编辑方法
|
|
CN107460196A
(zh)
|
2017-08-25 |
2017-12-12 |
同济大学 |
一种免疫缺陷小鼠动物模型的构建方法及应用
|
|
CN107488649A
(zh)
|
2017-08-25 |
2017-12-19 |
南方医科大学 |
一种Cpf1和p300核心结构域的融合蛋白、相应的DNA靶向激活系统和应用
|
|
CN107541525B
(zh)
|
2017-08-26 |
2021-12-10 |
内蒙古大学 |
一种基于CRISPR/Cas9技术介导山羊Tβ4基因定点敲入的方法
|
|
CN107446932B
(zh)
|
2017-08-29 |
2020-02-21 |
江西省农业科学院 |
一个控制水稻雄性生殖发育基因及其应用
|
|
WO2019139645A2
(en)
|
2017-08-30 |
2019-07-18 |
President And Fellows Of Harvard College |
High efficiency base editors comprising gam
|
|
WO2019041296A1
(zh)
|
2017-09-01 |
2019-03-07 |
上海科技大学 |
一种碱基编辑系统及方法
|
|
CN107519492B
(zh)
|
2017-09-06 |
2019-01-25 |
武汉迈特维尔生物科技有限公司 |
使用CRISPR技术敲除miR-3187-3p在冠状动脉粥样硬化性心脏病中的应用
|
|
CN107362372B
(zh)
|
2017-09-07 |
2019-01-11 |
佛山波若恩生物科技有限公司 |
使用crispr技术在冠状动脉粥样硬化性心脏病中的应用
|
|
CN107641631A
(zh)
|
2017-09-07 |
2018-01-30 |
浙江工业大学 |
一种由化学转化介导的基于CRISPR/Cas9系统敲除大肠杆菌基因的方法
|
|
US11649442B2
(en)
|
2017-09-08 |
2023-05-16 |
The Regents Of The University Of California |
RNA-guided endonuclease fusion polypeptides and methods of use thereof
|
|
CN107502608B
(zh)
|
2017-09-08 |
2020-10-16 |
中山大学 |
用于敲除人ALDH2基因的sgRNA、ALDH2基因缺失细胞株的构建方法及应用
|
|
CN107557455A
(zh)
|
2017-09-15 |
2018-01-09 |
国家纳米科学中心 |
一种基于CRISPR‑Cas13a的特异性核酸片段的检测方法
|
|
CN107475300B
(zh)
|
2017-09-18 |
2020-04-21 |
上海市同济医院 |
Ifit3-eKO1基因敲除小鼠动物模型的构建方法和应用
|
|
US11624130B2
(en)
|
2017-09-18 |
2023-04-11 |
President And Fellows Of Harvard College |
Continuous evolution for stabilized proteins
|
|
CN107557390A
(zh)
|
2017-09-18 |
2018-01-09 |
江南大学 |
一种筛选cho细胞系高表达位点的方法
|
|
CN107630041A
(zh)
|
2017-09-19 |
2018-01-26 |
安徽大学 |
一种基于维吉尼亚链霉菌IBL14 I‑B型Cas系统的真核基因编辑方法
|
|
CN107557378B
(zh)
|
2017-09-19 |
2025-04-25 |
安徽大学 |
一种基于I型CRISPR-Cas系统中基因cas7-3的真核基因编辑方法
|
|
CN107523583A
(zh)
|
2017-09-19 |
2017-12-29 |
安徽大学 |
一种源于I型CRISPR‑Cas系统中基因cas5‑3的原核基因编辑方法
|
|
CN107630042A
(zh)
|
2017-09-19 |
2018-01-26 |
安徽大学 |
一种源于I型Cas系统4个cas基因的原核生物基因编辑方法
|
|
CN107557373A
(zh)
|
2017-09-19 |
2018-01-09 |
安徽大学 |
一种基于I‑B型CRISPR‑Cas系统基因cas3的基因编辑方法
|
|
CN107619837A
(zh)
|
2017-09-20 |
2018-01-23 |
西北农林科技大学 |
利用Cas9切割核酸酶介导Ipr1定点插入获取转基因牛胎儿成纤维细胞的方法
|
|
CN107513531B
(zh)
|
2017-09-21 |
2020-02-21 |
无锡市妇幼保健院 |
用于内源性过表达lncRNA-XIST的gRNA靶点序列及其应用
|
|
CN107686848A
(zh)
|
2017-09-26 |
2018-02-13 |
中山大学孙逸仙纪念医院 |
转座子协同CRISPR/Cas9系统的稳定敲除单质粒载体及其应用
|
|
CN107760652A
(zh)
|
2017-09-29 |
2018-03-06 |
华南理工大学 |
CRISPR/CAS9介导药物转运体靶向性敲除的caco‑2细胞模型及其方法
|
|
MY204993A
(en)
|
2017-09-29 |
2024-09-26 |
Intellia Therapeutics Inc |
Formulations
|
|
CN107557394A
(zh)
|
2017-09-29 |
2018-01-09 |
南京鼓楼医院 |
降低CRISPR/Cas9介导的胚胎基因编辑脱靶率的方法
|
|
CN107630006B
(zh)
|
2017-09-30 |
2020-09-11 |
山东兴瑞生物科技有限公司 |
一种制备tcr与hla双基因敲除的t细胞的方法
|
|
CN107760663A
(zh)
|
2017-09-30 |
2018-03-06 |
新疆大学 |
油莎草pepc基因的克隆及表达载体的构建和应用
|
|
CN107828794A
(zh)
|
2017-09-30 |
2018-03-23 |
上海市农业生物基因中心 |
一种水稻耐盐基因OsRR22突变体、其编码的氨基酸序列、植株及该突变体的创制方法
|
|
CN107604003A
(zh)
|
2017-10-10 |
2018-01-19 |
南方医科大学 |
一种基于线性化crispr‑cas9慢病毒载体基因敲除试剂盒及其应用
|
|
CN107474129B
(zh)
|
2017-10-12 |
2018-10-19 |
江西汉氏联合干细胞科技有限公司 |
特异性增强crispr-cas系统基因编辑效率的方法
|
|
CN107557381A
(zh)
|
2017-10-12 |
2018-01-09 |
南京农业大学 |
一种白菜CRISPR‑Cas9基因编辑体系的建立及其应用
|
|
EP3694530A4
(en)
|
2017-10-12 |
2021-06-30 |
Wave Life Sciences Ltd. |
COMPOSITIONS OF OLIGONUCLEOTIDES AND RELATED PROCESSES
|
|
CN108102940B
(zh)
|
2017-10-12 |
2021-07-13 |
中石化上海工程有限公司 |
一株利用CRISPR/Cas9系统敲除XKS1基因的工业酿酒酵母菌株及构建方法
|
|
CN108103586A
(zh)
|
2017-10-13 |
2018-06-01 |
上海科技大学 |
一种CRISPR/Cas9随机文库及其构建和应用
|
|
CN107586779B
(zh)
|
2017-10-14 |
2018-08-28 |
天津金匙生物科技有限公司 |
使用crispr-cas系统对间充质干细胞进行casp3基因敲除的方法
|
|
CN107619829B
(zh)
|
2017-10-14 |
2018-08-24 |
南京平港生物技术有限公司 |
使用crispr-cas系统对间充质干细胞进行gins2基因敲除的方法
|
|
CN111757937A
(zh)
|
2017-10-16 |
2020-10-09 |
布罗德研究所股份有限公司 |
腺苷碱基编辑器的用途
|
|
CN107523567A
(zh)
|
2017-10-16 |
2017-12-29 |
遵义医学院 |
一种敲除人ezrin基因增强子的食管癌细胞株的构建方法
|
|
CN107760715B
(zh)
|
2017-10-17 |
2021-12-10 |
张业胜 |
一种转基因载体及其构建方法和应用
|
|
CN107937427A
(zh)
|
2017-10-20 |
2018-04-20 |
广东石油化工学院 |
一种基于CRISPR/Cas9体系的同源修复载体构建方法
|
|
EP3701025A4
(en)
|
2017-10-23 |
2021-07-28 |
The Broad Institute, Inc. |
NUCLEIC ACID TARGETED EDITING SYSTEMS, METHODS AND COMPOSITIONS
|
|
CN107893086B
(zh)
|
2017-10-24 |
2021-09-03 |
中国科学院武汉植物园 |
快速构建配对sgRNA的Cas9双元表达载体文库的方法
|
|
IL274396B2
(en)
|
2017-11-02 |
2025-10-01 |
Wistar Inst |
Methods for rescuing stop codons through genetic rearrangement with ACE–tRNA
|
|
CN107760684B
(zh)
|
2017-11-03 |
2018-09-25 |
上海拉德钫斯生物科技有限公司 |
使用crispr-cas系统对间充质干细胞进行rbm17基因敲除的方法
|
|
WO2019090367A1
(en)
|
2017-11-05 |
2019-05-09 |
Aveterra Corp |
Method and apparatus for automated composting of organic wastes
|
|
CN107858346B
(zh)
|
2017-11-06 |
2020-06-16 |
天津大学 |
一种敲除酿酒酵母染色体的方法
|
|
CN107794276A
(zh)
|
2017-11-08 |
2018-03-13 |
中国农业科学院作物科学研究所 |
一种crispr介导快速有效的农作物定点基因片段或等位基因替换方法和体系
|
|
WO2019092042A1
(en)
|
2017-11-10 |
2019-05-16 |
Novozymes A/S |
Temperature-sensitive cas9 protein
|
|
CN107630043A
(zh)
|
2017-11-14 |
2018-01-26 |
吉林大学 |
采用敲除技术建立Gadd45a敲除兔模型的方法
|
|
CN108441519A
(zh)
|
2017-11-15 |
2018-08-24 |
中国农业大学 |
在crispr/cas9基因编辑中提高同源修复效率的方法
|
|
CN107858373B
(zh)
|
2017-11-16 |
2020-03-17 |
山东省千佛山医院 |
内皮细胞条件性敲除ccr5基因小鼠模型的构建方法
|
|
CN107893075A
(zh)
|
2017-11-17 |
2018-04-10 |
和元生物技术(上海)股份有限公司 |
CRISPR‑Cas9靶向敲除人肠癌细胞RITA基因及其特异性的sgRNA
|
|
CN108192956B
(zh)
|
2017-11-17 |
2021-06-01 |
东南大学 |
一种基于Cas9核酸酶的DNA检测分析方法及其应用
|
|
CN107828874B
(zh)
|
2017-11-20 |
2020-10-16 |
东南大学 |
一种基于crispr的dna检测和分型方法及其应用
|
|
CN107653256A
(zh)
|
2017-11-21 |
2018-02-02 |
云南省烟草农业科学研究院 |
一种烟草多酚氧化酶基因NtPPO1及其定点突变方法与应用
|
|
CN107904261A
(zh)
|
2017-11-21 |
2018-04-13 |
福州大学 |
CRISPR/Cas9纳米基因系统的制备及其在转染方面的应用
|
|
CN107893076A
(zh)
|
2017-11-23 |
2018-04-10 |
和元生物技术(上海)股份有限公司 |
CRISPR‑Cas9靶向敲除人乳腺癌细胞RASSF2基因及其特异性的sgRNA
|
|
CN107937432B
(zh)
|
2017-11-24 |
2020-05-01 |
华中农业大学 |
一种基于crispr系统的基因组编辑方法及其应用
|
|
CN107937501A
(zh)
|
2017-11-24 |
2018-04-20 |
安徽师范大学 |
一种快速简便的筛选CRISPR/Cas基因编辑阳性对象的方法
|
|
CN107828738A
(zh)
|
2017-11-28 |
2018-03-23 |
新乡医学院 |
一种dna甲基转移酶缺陷型cho细胞系及其制备方法及应用
|
|
CN107988256B
(zh)
|
2017-12-01 |
2020-07-28 |
暨南大学 |
人亨廷顿基因敲入用重组载体及其构建方法和在模型猪构建中的应用
|
|
CN108148873A
(zh)
|
2017-12-06 |
2018-06-12 |
南方医科大学 |
一种cav-1基因缺失斑马鱼及其制备方法
|
|
CN108570479B
(zh)
|
2017-12-06 |
2020-04-03 |
内蒙古大学 |
一种基于CRISPR/Cas9技术介导绒山羊VEGF基因定点敲入的方法
|
|
CN107974466B
(zh)
|
2017-12-07 |
2020-09-29 |
中国科学院水生生物研究所 |
一种鲟鱼CRISPR/Cas9基因编辑方法
|
|
CN108148835A
(zh)
|
2017-12-07 |
2018-06-12 |
和元生物技术(上海)股份有限公司 |
CRISPR-Cas9靶向敲除SLC30A1基因及其特异性的sgRNA
|
|
CN108315330B
(zh)
|
2017-12-07 |
2020-05-19 |
嘉兴市第一医院 |
CRISPR-Cas9系统特异性靶向人RSPO2基因的sgRNA及敲除方法和应用
|
|
CN108251423B
(zh)
|
2017-12-07 |
2020-11-06 |
嘉兴市第一医院 |
CRISPR-Cas9系统特异性靶向人RSPO2基因的sgRNA及激活方法和应用
|
|
US20210163933A1
(en)
|
2017-12-11 |
2021-06-03 |
University Of Massachusetts |
Arc protein extracellular vesicle nucleic acid delivery platform
|
|
CN108103090B
(zh)
|
2017-12-12 |
2021-06-15 |
中山大学附属第一医院 |
靶向RNA甲基化的RNA Cas9-m6A修饰载体系统及其构建方法和应用
|
|
CN107828826A
(zh)
|
2017-12-12 |
2018-03-23 |
南开大学 |
一种体外高效获得神经干细胞的方法
|
|
CN108103098B
(zh)
|
2017-12-14 |
2020-07-28 |
华南理工大学 |
一种化合物皮肤致敏体外评估细胞模型及其构建方法
|
|
US11578323B2
(en)
|
2017-12-14 |
2023-02-14 |
Bayer Healthcare Llc |
RNA-programmable endonuclease systems and their use in genome editing and other applications
|
|
EP3724214A4
(en)
|
2017-12-15 |
2021-09-01 |
The Broad Institute Inc. |
SYSTEMS AND METHODS FOR PREDICTING REPAIR RESULTS IN GENETIC ENGINEERING
|
|
CN107988268A
(zh)
|
2017-12-18 |
2018-05-04 |
湖南师范大学 |
一种基因敲除选育tcf25基因缺失型斑马鱼的方法
|
|
CN108018316A
(zh)
|
2017-12-20 |
2018-05-11 |
湖南师范大学 |
一种基因敲除选育rmnd5b基因缺失型斑马鱼的方法
|
|
CN108048466B
(zh)
|
2017-12-21 |
2020-02-07 |
嘉兴市第一医院 |
CRISPR-Cas13a系统特异性靶向人RSPO2基因的crRNA及系统和应用
|
|
WO2019123430A1
(en)
|
2017-12-21 |
2019-06-27 |
Casebia Therapeutics Llp |
Materials and methods for treatment of usher syndrome type 2a and/or non-syndromic autosomal recessive retinitis pigmentosa (arrp)
|
|
EP3728575A4
(en)
|
2017-12-22 |
2021-11-24 |
The Broad Institute, Inc. |
CAS12B SYSTEMS, METHODS AND COMPOSITIONS FOR SPECIFIC EDITING OF DNA BASES
|
|
RU2652899C1
(ru)
|
2017-12-28 |
2018-05-03 |
Федеральное бюджетное учреждение науки "Центральный научно-исследовательский институт эпидемиологии" Федеральной службы по надзору в сфере защиты прав потребителей и благополучия человека (ФБУН ЦНИИ Эпидемиологии Роспотребнадзора) |
РНК-проводники для подавления репликации вируса гепатита B и для элиминации вируса гепатита B из клетки-хозяина
|
|
CN107893080A
(zh)
|
2017-12-29 |
2018-04-10 |
江苏省农业科学院 |
一种靶向大鼠Inhba基因的sgRNA及其应用
|
|
CN107988229B
(zh)
|
2018-01-05 |
2020-01-07 |
中国农业科学院作物科学研究所 |
一种利用CRISPR-Cas修饰OsTAC1基因获得分蘖改变的水稻的方法
|
|
CN107988246A
(zh)
|
2018-01-05 |
2018-05-04 |
汕头大学医学院 |
一种基因敲除载体及其斑马鱼胶质瘤模型
|
|
CN108103092B
(zh)
|
2018-01-05 |
2021-02-12 |
中国农业科学院作物科学研究所 |
利用CRISPR-Cas系统修饰OsHPH基因获得矮化水稻的系统及其应用
|
|
WO2019139951A1
(en)
|
2018-01-09 |
2019-07-18 |
The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services |
Detecting protein interaction sites in nucleic acids
|
|
CN108559760A
(zh)
|
2018-01-09 |
2018-09-21 |
陕西师范大学 |
基于CRISPR靶向基因组修饰技术建立荧光素酶knock-in细胞系的方法
|
|
CN108559730B
(zh)
|
2018-01-12 |
2021-09-24 |
中国人民解放军第四军医大学 |
利用CRISPR/Cas9技术构建Hutat2:Fc基因敲入单核细胞的实验方法
|
|
CN108148837A
(zh)
|
2018-01-12 |
2018-06-12 |
南京医科大学 |
ApoE-CRISPR/Cas9载体及其在敲除ApoE基因中的应用
|
|
US11268092B2
(en)
|
2018-01-12 |
2022-03-08 |
GenEdit, Inc. |
Structure-engineered guide RNA
|
|
CN108251451A
(zh)
|
2018-01-16 |
2018-07-06 |
西南大学 |
HTT的CRISPR/Cas9-gRNA打靶序列对、质粒及其应用
|
|
CN108251452A
(zh)
|
2018-01-17 |
2018-07-06 |
扬州大学 |
一种表达Cas9基因的转基因斑马鱼及其构建方法和应用
|
|
KR102839528B1
(ko)
|
2018-01-23 |
2025-07-29 |
기초과학연구원 |
연장된 단일 가이드 rna 및 그 용도
|
|
CN108359712B
(zh)
|
2018-02-09 |
2020-06-26 |
广东省农业科学院农业生物基因研究中心 |
一种快速高效筛选SgRNA靶向DNA序列的方法
|
|
CN208034188U
(zh)
|
2018-02-09 |
2018-11-02 |
衡阳市振洋汽车配件有限公司 |
一种快速定位的加工孔用夹具
|
|
CN108559745A
(zh)
|
2018-02-10 |
2018-09-21 |
和元生物技术(上海)股份有限公司 |
基于CRISPR-Cas9技术提高B16F10细胞转染效率的方法
|
|
CN108486145A
(zh)
|
2018-02-12 |
2018-09-04 |
中国科学院遗传与发育生物学研究所 |
基于CRISPR/Cas9的植物高效同源重组方法
|
|
CN108359691B
(zh)
|
2018-02-12 |
2021-09-28 |
中国科学院重庆绿色智能技术研究院 |
利用mito-CRISPR/Cas9系统敲除异常线粒体DNA的试剂盒及方法
|
|
US12060586B2
(en)
|
2018-02-15 |
2024-08-13 |
The Broad Institute, Inc. |
Cell data recorders and uses thereof
|
|
CN109021111B
(zh)
|
2018-02-23 |
2021-12-07 |
上海科技大学 |
一种基因碱基编辑器
|
|
US20220307001A1
(en)
|
2018-02-27 |
2022-09-29 |
President And Fellows Of Harvard College |
Evolved cas9 variants and uses thereof
|
|
CN108396027A
(zh)
|
2018-02-27 |
2018-08-14 |
和元生物技术(上海)股份有限公司 |
CRISPR-Cas9靶向敲除人肠癌细胞DEAF1基因及其特异性的sgRNA
|
|
CN108486159B
(zh)
|
2018-03-01 |
2021-10-22 |
南通大学附属医院 |
一种敲除GRIN2D基因的CRISPR-Cas9系统及其应用
|
|
CN108342480B
(zh)
|
2018-03-05 |
2022-03-01 |
北京医院 |
一种基因变异检测质控物及其制备方法
|
|
CN108410906A
(zh)
|
2018-03-05 |
2018-08-17 |
淮海工学院 |
一种适用于海洋甲壳类线粒体基因组的CRISPR/Cpf1基因编辑方法
|
|
CN108410907B
(zh)
|
2018-03-08 |
2021-08-27 |
湖南农业大学 |
一种基于CRISPR/Cas9技术实现HMGCR基因敲除的方法
|
|
CN108410911B
(zh)
|
2018-03-09 |
2021-08-20 |
广西医科大学 |
基于CRISPR/Cas9技术构建的LMNA基因敲除的细胞系
|
|
CN108486108B
(zh)
|
2018-03-16 |
2020-10-09 |
华南农业大学 |
一种敲除人hmgb1基因的细胞株及其应用
|
|
CN108486146B
(zh)
|
2018-03-16 |
2021-02-19 |
中国农业科学院作物科学研究所 |
LbCpf1-RR突变体用于CRISPR/Cpf1系统在植物基因编辑中的应用
|
|
WO2019183641A1
(en)
|
2018-03-23 |
2019-09-26 |
Massachusetts Eye And Ear Infirmary |
Crispr/cas9-mediated exon-skipping approach for ush2a-associated usher syndrome
|
|
CN108384784A
(zh)
|
2018-03-23 |
2018-08-10 |
广西医科大学 |
一种利用CRISPR/Cas9技术敲除Endoglin基因的方法
|
|
CN108504685A
(zh)
|
2018-03-27 |
2018-09-07 |
宜明细胞生物科技有限公司 |
一种利用CRISPR/Cas9系统同源重组修复IL-2RG缺陷基因的方法
|
|
CN108410877A
(zh)
|
2018-03-27 |
2018-08-17 |
和元生物技术(上海)股份有限公司 |
CRISPR-Cas9靶向敲除人细胞SANIL1基因及其特异性的sgRNA
|
|
CN108486234B
(zh)
|
2018-03-29 |
2022-02-11 |
东南大学 |
一种crispr分型pcr的方法及其应用
|
|
CN108424931A
(zh)
|
2018-03-29 |
2018-08-21 |
内蒙古大学 |
CRISPR/Cas9技术介导山羊VEGF基因定点整合的方法
|
|
CN108486154A
(zh)
|
2018-04-04 |
2018-09-04 |
福州大学 |
一种唾液酸酶基因敲除小鼠模型的构建方法及其应用
|
|
CN108504693A
(zh)
|
2018-04-04 |
2018-09-07 |
首都医科大学附属北京朝阳医院 |
利用Crispr技术敲除T合酶基因构建的O-型糖基化异常的结肠癌细胞系
|
|
CN108486111A
(zh)
|
2018-04-04 |
2018-09-04 |
山西医科大学 |
CRISPR-Cas9靶向敲除人SMYD3基因的方法及其特异性sgRNA
|
|
CN108441520B
(zh)
|
2018-04-04 |
2020-07-31 |
苏州大学 |
利用CRISPR/Cas9系统构建的基因条件性敲除方法
|
|
CN108753772B
(zh)
|
2018-04-04 |
2020-10-30 |
南华大学 |
基于CRISPR/Cas技术敲除CAPNS1基因的人神经母细胞瘤细胞系的构建方法
|
|
CN108504657B
(zh)
|
2018-04-12 |
2019-06-14 |
中南民族大学 |
利用crispr-cas9技术敲除hek293t细胞kdm2a基因的方法
|
|
CN108753817A
(zh)
|
2018-04-13 |
2018-11-06 |
北京华伟康信生物科技有限公司 |
增强细胞的抗癌能力的方法及采用该方法获得的增强型细胞
|
|
CN108588182B
(zh)
|
2018-04-13 |
2025-11-28 |
武汉中科先进技术研究院有限公司 |
基于crispr-链取代的等温扩增及检测技术
|
|
WO2019204369A1
(en)
|
2018-04-17 |
2019-10-24 |
Applied Stemcell, Inc. |
Compositions and methods for treating spinal muscular atrophy
|
|
CN108753832A
(zh)
|
2018-04-20 |
2018-11-06 |
中山大学 |
一种利用CRISPR/Cas9编辑大白猪CD163基因的方法
|
|
CN108823248A
(zh)
|
2018-04-20 |
2018-11-16 |
中山大学 |
一种利用CRISPR/Cas9编辑陆川猪CD163基因的方法
|
|
CN108588071A
(zh)
|
2018-04-25 |
2018-09-28 |
和元生物技术(上海)股份有限公司 |
CRISPR-Cas9靶向敲除人肠癌细胞CNR1基因及其特异性的sgRNA
|
|
CN108546712B
(zh)
|
2018-04-26 |
2020-08-07 |
中国农业科学院作物科学研究所 |
一种利用CRISPR/LbCpf1系统实现目的基因在植物中同源重组的方法
|
|
CN108707621B
(zh)
|
2018-04-26 |
2021-02-12 |
中国农业科学院作物科学研究所 |
一种CRISPR/Cpf1系统介导的以RNA转录本为修复模板的同源重组方法
|
|
CN108588128A
(zh)
|
2018-04-26 |
2018-09-28 |
南昌大学 |
一种高效率大豆CRISPR/Cas9系统的构建方法及应用
|
|
CN108642053A
(zh)
|
2018-04-28 |
2018-10-12 |
和元生物技术(上海)股份有限公司 |
CRISPR-Cas9靶向敲除人肠癌细胞PPP1R1C基因及其特异性的sgRNA
|
|
US12398182B2
(en)
|
2018-05-01 |
2025-08-26 |
Wake Forest University Health Sciences |
Lentiviral-based vectors and related systems and methods for eukaryotic gene editing
|
|
CN108611364A
(zh)
|
2018-05-03 |
2018-10-02 |
南京农业大学 |
一种非转基因crispr突变体的制备方法
|
|
CN108588123A
(zh)
|
2018-05-07 |
2018-09-28 |
南京医科大学 |
CRISPR/Cas9载体组合在制备基因敲除猪的血液制品中的应用
|
|
US12133884B2
(en)
|
2018-05-11 |
2024-11-05 |
Beam Therapeutics Inc. |
Methods of substituting pathogenic amino acids using programmable base editor systems
|
|
CN108610399B
(zh)
|
2018-05-14 |
2019-09-27 |
河北万玛生物医药有限公司 |
特异性增强crispr-cas系统在表皮干细胞中进行基因编辑效率的方法
|
|
CN108546717A
(zh)
|
2018-05-15 |
2018-09-18 |
吉林大学 |
反义lncRNA介导顺式调控抑制靶基因表达的方法
|
|
CN108624622A
(zh)
|
2018-05-16 |
2018-10-09 |
湖南艾佳生物科技股份有限公司 |
一种基于CRISPR-Cas9系统构建的能分泌小鼠白细胞介素-6的基因工程细胞株
|
|
CN108546718B
(zh)
|
2018-05-16 |
2021-07-09 |
康春生 |
crRNA介导的CRISPR/Cas13a基因编辑系统在肿瘤细胞中的应用
|
|
CN108642055B
(zh)
|
2018-05-17 |
2021-12-03 |
吉林大学 |
能有效编辑猪miR-17-92基因簇的sgRNA
|
|
CN108642090A
(zh)
|
2018-05-18 |
2018-10-12 |
中国人民解放军总医院 |
基于CRISPR/Cas9技术获得Nogo-B敲除模式小鼠的方法及应用
|
|
CN108642077A
(zh)
|
2018-05-18 |
2018-10-12 |
江苏省农业科学院 |
基于CRISPR/Cas9基因编辑技术选育绿豆不育突变体的方法及专用gRNA
|
|
CN108642078A
(zh)
|
2018-05-18 |
2018-10-12 |
江苏省农业科学院 |
基于CRISPR/Cas9基因编辑技术选育绿豆开花传粉突变体的方法及专用gRNA
|
|
CN108559732A
(zh)
|
2018-05-21 |
2018-09-21 |
陕西师范大学 |
基于CRISPR/Cas9靶向基因组修饰技术建立KI-T2A-luciferase细胞系的方法
|
|
CN108707620A
(zh)
|
2018-05-22 |
2018-10-26 |
西北农林科技大学 |
一种Gene drive载体及构建方法
|
|
WO2019226953A1
(en)
|
2018-05-23 |
2019-11-28 |
The Broad Institute, Inc. |
Base editors and uses thereof
|
|
US11117812B2
(en)
|
2018-05-24 |
2021-09-14 |
Aqua-Aerobic Systems, Inc. |
System and method of solids conditioning in a filtration system
|
|
CN108690844B
(zh)
|
2018-05-25 |
2021-10-15 |
西南大学 |
HTT的CRISPR/Cas9-gRNA打靶序列对、质粒及HD细胞模型
|
|
CN108707629A
(zh)
|
2018-05-28 |
2018-10-26 |
上海海洋大学 |
斑马鱼notch1b基因突变体的制备方法
|
|
CN108707628B
(zh)
|
2018-05-28 |
2021-11-23 |
上海海洋大学 |
斑马鱼notch2基因突变体的制备方法
|
|
CN108823249A
(zh)
|
2018-05-28 |
2018-11-16 |
上海海洋大学 |
CRISPR/Cas9构建notch1a突变体斑马鱼的方法
|
|
CN108753835A
(zh)
|
2018-05-30 |
2018-11-06 |
中山大学 |
一种利用CRISPR/Cas9编辑猪BMP15基因的方法
|
|
CN108707604B
(zh)
|
2018-05-30 |
2019-07-23 |
江西汉氏联合干细胞科技有限公司 |
表皮干细胞中采用CRISPR-Cas系统进行CNE10基因敲除
|
|
CN108753836B
(zh)
|
2018-06-04 |
2021-10-12 |
北京大学 |
一种利用rna干扰机制的基因调控或编辑系统
|
|
CN108715850B
(zh)
|
2018-06-05 |
2020-10-23 |
艾一生命科技(广东)有限公司 |
表皮干细胞中采用CRISPR-Cas系统进行GING2基因敲除
|
|
JP7708660B2
(ja)
|
2018-06-05 |
2025-07-15 |
ライフエディット,インコーポレイティド |
Rna誘導型ヌクレアーゼ、その活性な断片とバリアント、ならびに利用法
|
|
CN108753813B
(zh)
|
2018-06-08 |
2021-08-24 |
中国水稻研究所 |
获得无标记转基因植物的方法
|
|
CN108753783A
(zh)
|
2018-06-13 |
2018-11-06 |
上海市同济医院 |
Sqstm1全基因敲除小鼠动物模型的构建方法和应用
|
|
US11913044B2
(en)
|
2018-06-14 |
2024-02-27 |
President And Fellows Of Harvard College |
Evolution of cytidine deaminases
|
|
CN108728486A
(zh)
|
2018-06-20 |
2018-11-02 |
江苏省农业科学院 |
一种茄子CRISPR/Cas9基因敲除载体的构建方法和应用
|
|
CN108841845A
(zh)
|
2018-06-21 |
2018-11-20 |
广东石油化工学院 |
一种带有筛选标记的CRISPR/Cas9载体及其构建方法
|
|
CN108893529A
(zh)
|
2018-06-25 |
2018-11-27 |
武汉博杰生物医学科技有限公司 |
一种基于CRISPR技术特异性检测人KRAS基因2号及3号外显子突变的crRNA
|
|
CN108866093B
(zh)
|
2018-07-04 |
2021-07-09 |
广东三杰牧草生物科技有限公司 |
一种利用CRISPR/Cas9系统对紫花苜蓿基因定点突变的方法
|
|
CN108913714A
(zh)
|
2018-07-05 |
2018-11-30 |
江西省超级水稻研究发展中心 |
一种利用CRISPR/Cas9系统敲除BADH2基因创制香稻的方法
|
|
CN108795902A
(zh)
|
2018-07-05 |
2018-11-13 |
深圳三智医学科技有限公司 |
一种安全高效的CRISPR/Cas9基因编辑技术
|
|
WO2020014261A1
(en)
|
2018-07-09 |
2020-01-16 |
The Broad Institute, Inc. |
Rna programmable epigenetic rna modifiers and uses thereof
|
|
CN108913691B
(zh)
|
2018-07-16 |
2020-09-01 |
山东华御生物科技有限公司 |
表皮干细胞中采用CRISPR-Cas系统进行Card3基因敲除
|
|
CN108913664B
(zh)
|
2018-07-20 |
2020-09-04 |
嘉兴学院 |
一种CRISPR/Cas9基因编辑方法敲除卵巢癌细胞中CFP1基因的方法
|
|
CN108853133A
(zh)
|
2018-07-25 |
2018-11-23 |
福州大学 |
一种PAMAM与CRISPR/Cas9系统重组质粒递送纳米粒的制备方法
|
|
CN108823291B
(zh)
|
2018-07-25 |
2022-04-12 |
领航医学科技(深圳)有限公司 |
基于crispr技术的特异性核酸片段定量检测方法
|
|
CN113348245A
(zh)
|
2018-07-31 |
2021-09-03 |
博德研究所 |
新型crispr酶和系统
|
|
CN108913717A
(zh)
|
2018-08-01 |
2018-11-30 |
河南农业大学 |
一种利用CRISPR/Cas9系统对水稻PHYB基因定点突变的方法
|
|
AU2019316094A1
(en)
|
2018-08-03 |
2021-02-25 |
Beam Therapeutics Inc. |
Multi-effector nucleobase editors and methods of using same to modify a nucleic acid target sequence
|
|
WO2020041751A1
(en)
|
2018-08-23 |
2020-02-27 |
The Broad Institute, Inc. |
Cas9 variants having non-canonical pam specificities and uses thereof
|
|
CA3109953A1
(en)
|
2018-08-28 |
2020-03-05 |
Flagship Pioneering Innovations Vi, Llc |
Methods and compositions for modulating a genome
|
|
US20240173430A1
(en)
|
2018-09-05 |
2024-05-30 |
The Broad Institute, Inc. |
Base editing for treating hutchinson-gilford progeria syndrome
|
|
MY209774A
(en)
|
2018-10-15 |
2025-08-03 |
Univ Massachusetts |
Programmable dna base editing by nme2cas9-deaminase fusion proteins
|
|
US20220380740A1
(en)
|
2018-10-24 |
2022-12-01 |
The Broad Institute, Inc. |
Constructs for improved hdr-dependent genomic editing
|
|
US12281338B2
(en)
|
2018-10-29 |
2025-04-22 |
The Broad Institute, Inc. |
Nucleobase editors comprising GeoCas9 and uses thereof
|
|
WO2020102659A1
(en)
|
2018-11-15 |
2020-05-22 |
The Broad Institute, Inc. |
G-to-t base editors and uses thereof
|
|
WO2020102709A1
(en)
|
2018-11-16 |
2020-05-22 |
The Regents Of The University Of California |
Compositions and methods for delivering crispr/cas effector polypeptides
|
|
CN109517841B
(zh)
|
2018-12-05 |
2020-10-30 |
华东师范大学 |
一种用于核苷酸序列修饰的组合物、方法与应用
|
|
US12351837B2
(en)
|
2019-01-23 |
2025-07-08 |
The Broad Institute, Inc. |
Supernegatively charged proteins and uses thereof
|
|
WO2020180975A1
(en)
|
2019-03-04 |
2020-09-10 |
President And Fellows Of Harvard College |
Highly multiplexed base editing
|
|
WO2020181193A1
(en)
|
2019-03-06 |
2020-09-10 |
The Broad Institute, Inc. |
T:a to a:t base editing through adenosine methylation
|
|
WO2020181202A1
(en)
|
2019-03-06 |
2020-09-10 |
The Broad Institute, Inc. |
A:t to t:a base editing through adenine deamination and oxidation
|
|
WO2020181180A1
(en)
|
2019-03-06 |
2020-09-10 |
The Broad Institute, Inc. |
A:t to c:g base editors and uses thereof
|
|
WO2020181195A1
(en)
|
2019-03-06 |
2020-09-10 |
The Broad Institute, Inc. |
T:a to a:t base editing through adenine excision
|
|
WO2020181178A1
(en)
|
2019-03-06 |
2020-09-10 |
The Broad Institute, Inc. |
T:a to a:t base editing through thymine alkylation
|
|
GB2601617B
(en)
|
2019-03-19 |
2024-02-21 |
Broad Inst Inc |
Methods and compositions for editing nucleotide sequences
|
|
US20220204975A1
(en)
|
2019-04-12 |
2022-06-30 |
President And Fellows Of Harvard College |
System for genome editing
|
|
EP3956349A1
(en)
|
2019-04-17 |
2022-02-23 |
The Broad Institute, Inc. |
Adenine base editors with reduced off-target effects
|
|
US20220249697A1
(en)
|
2019-05-20 |
2022-08-11 |
The Broad Institute, Inc. |
Aav delivery of nucleobase editors
|
|
US20220315906A1
(en)
|
2019-08-08 |
2022-10-06 |
The Broad Institute, Inc. |
Base editors with diversified targeting scope
|
|
WO2021030666A1
(en)
|
2019-08-15 |
2021-02-18 |
The Broad Institute, Inc. |
Base editing by transglycosylation
|
|
WO2021072328A1
(en)
|
2019-10-10 |
2021-04-15 |
The Broad Institute, Inc. |
Methods and compositions for prime editing rna
|
|
WO2021108717A2
(en)
|
2019-11-26 |
2021-06-03 |
The Broad Institute, Inc |
Systems and methods for evaluating cas9-independent off-target editing of nucleic acids
|
|
EP4085141A4
(en)
|
2019-12-30 |
2024-03-06 |
The Broad Institute, Inc. |
GENOME EDITING USING ACTIVATED, FULLY ACTIVE CRISPR COMPLEXES OF REVERSE TRANSCRIPTASE
|
|
EP4097124A1
(en)
|
2020-01-28 |
2022-12-07 |
The Broad Institute Inc. |
Base editors, compositions, and methods for modifying the mitochondrial genome
|
|
WO2021158995A1
(en)
|
2020-02-05 |
2021-08-12 |
The Broad Institute, Inc. |
Base editor predictive algorithm and method of use
|
|
WO2021158999A1
(en)
|
2020-02-05 |
2021-08-12 |
The Broad Institute, Inc. |
Gene editing methods for treating spinal muscular atrophy
|
|
WO2021158921A2
(en)
|
2020-02-05 |
2021-08-12 |
The Broad Institute, Inc. |
Adenine base editors and uses thereof
|
|
US20230127008A1
(en)
|
2020-03-11 |
2023-04-27 |
The Broad Institute, Inc. |
Stat3-targeted base editor therapeutics for the treatment of melanoma and other cancers
|
|
US20230159913A1
(en)
|
2020-04-28 |
2023-05-25 |
The Broad Institute, Inc. |
Targeted base editing of the ush2a gene
|
|
EP4146804A1
(en)
|
2020-05-08 |
2023-03-15 |
The Broad Institute Inc. |
Methods and compositions for simultaneous editing of both strands of a target double-stranded nucleotide sequence
|
|
AU2021350835A1
(en)
|
2020-09-24 |
2023-04-27 |
President And Fellows Of Harvard College |
Prime editing guide rnas, compositions thereof, and methods of using the same
|
|
CA3203876A1
(en)
|
2021-01-11 |
2022-07-14 |
David R. Liu |
Prime editor variants, constructs, and methods for enhancing prime editing efficiency and precision
|
|
WO2022261509A1
(en)
|
2021-06-11 |
2022-12-15 |
The Broad Institute, Inc. |
Improved cytosine to guanine base editors
|
|
CA3227004A1
(en)
|
2021-08-06 |
2023-02-09 |
The Broad Institute, Inc. |
Improved prime editors and methods of use
|