JP2022028828A5 - - Google Patents

Download PDF

Info

Publication number
JP2022028828A5
JP2022028828A5 JP2021187540A JP2021187540A JP2022028828A5 JP 2022028828 A5 JP2022028828 A5 JP 2022028828A5 JP 2021187540 A JP2021187540 A JP 2021187540A JP 2021187540 A JP2021187540 A JP 2021187540A JP 2022028828 A5 JP2022028828 A5 JP 2022028828A5
Authority
JP
Japan
Prior art keywords
invention described
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2021187540A
Other languages
English (en)
Japanese (ja)
Other versions
JP2022028828A (ja
Filing date
Publication date
Priority claimed from GBGB1421092.6A external-priority patent/GB201421092D0/en
Application filed filed Critical
Publication of JP2022028828A publication Critical patent/JP2022028828A/ja
Publication of JP2022028828A5 publication Critical patent/JP2022028828A5/ja
Priority to JP2023197836A priority Critical patent/JP2024016281A/ja
Pending legal-status Critical Current

Links

JP2021187540A 2014-11-27 2021-11-18 培養培地 Pending JP2022028828A (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2023197836A JP2024016281A (ja) 2014-11-27 2023-11-22 培養培地

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
GB1421092.6 2014-11-27
GBGB1421092.6A GB201421092D0 (en) 2014-11-27 2014-11-27 Culture medium
GB1507834.8 2015-05-07
GB1507834.8A GB2532814A (en) 2014-11-27 2015-05-07 Culture medium
PCT/EP2015/077990 WO2016083613A2 (en) 2014-11-27 2015-11-27 Culture medium
JP2017528087A JP7319027B2 (ja) 2014-11-27 2015-11-27 培養培地

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
JP2017528087A Division JP7319027B2 (ja) 2014-11-27 2015-11-27 培養培地

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2023197836A Division JP2024016281A (ja) 2014-11-27 2023-11-22 培養培地

Publications (2)

Publication Number Publication Date
JP2022028828A JP2022028828A (ja) 2022-02-16
JP2022028828A5 true JP2022028828A5 (enExample) 2022-07-06

Family

ID=52349560

Family Applications (3)

Application Number Title Priority Date Filing Date
JP2017528087A Active JP7319027B2 (ja) 2014-11-27 2015-11-27 培養培地
JP2021187540A Pending JP2022028828A (ja) 2014-11-27 2021-11-18 培養培地
JP2023197836A Pending JP2024016281A (ja) 2014-11-27 2023-11-22 培養培地

Family Applications Before (1)

Application Number Title Priority Date Filing Date
JP2017528087A Active JP7319027B2 (ja) 2014-11-27 2015-11-27 培養培地

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2023197836A Pending JP2024016281A (ja) 2014-11-27 2023-11-22 培養培地

Country Status (8)

Country Link
US (2) US11130943B2 (enExample)
EP (1) EP3224346A2 (enExample)
JP (3) JP7319027B2 (enExample)
AU (3) AU2015352351B2 (enExample)
CA (1) CA2968736A1 (enExample)
GB (2) GB201421092D0 (enExample)
HK (1) HK1245323A1 (enExample)
WO (1) WO2016083613A2 (enExample)

Families Citing this family (75)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2412800A1 (en) 2010-07-29 2012-02-01 Koninklijke Nederlandse Akademie van Wetenschappen Liver organoid, uses thereof and culture method for obtaining them
PL3441458T3 (pl) 2009-02-03 2023-11-06 Koninklijke Nederlandse Akademie Van Wetenschappen Podłoże do hodowli nabłonkowych komórek macierzystych i organoidów zawierających wspomniane komórki macierzyste
US9719068B2 (en) 2010-05-06 2017-08-01 Children's Hospital Medical Center Methods and systems for converting precursor cells into intestinal tissues through directed differentiation
ES2561604T3 (es) 2011-12-19 2016-02-29 Umc Utrecht Holding B.V. Un ensayo cuantitativo rápido para medir la función de CFTR en un modelo de cultivo intestinal primario
US10597633B2 (en) 2014-05-16 2020-03-24 Koninklijke Nederlandse Akademie Van Wetenschappen Culture method for organoids
SG10201801654RA (en) 2014-05-28 2018-04-27 Childrens Hospital Med Ct Methods and systems for converting precursor cells into gastric tissues through directed differentiation
AU2015331848B2 (en) 2014-10-17 2022-03-03 Children's Hospital Medical Center, D/B/A Cincinnati Children's Hospital Medical Center In vivo model of human small intestine using pluripotent stem cells and methods of making and using same
GB201421092D0 (en) 2014-11-27 2015-01-14 Koninklijke Nederlandse Akademie Van Wetenschappen Culture medium
GB201421094D0 (en) 2014-11-27 2015-01-14 Koninklijke Nederlandse Akademie Van Wetenschappen Culture medium
GB201603569D0 (en) 2016-03-01 2016-04-13 Koninklijke Nederlandse Akademie Van Wetenschappen Improved differentiation method
CN109415685B (zh) 2016-05-05 2023-07-04 儿童医院医疗中心 用于体外制造胃底组织的方法和与其相关的组合物
GB201611982D0 (en) 2016-07-11 2016-08-24 Cellesce Ltd Cell culture
US20190161737A1 (en) * 2016-07-27 2019-05-30 Georgetown University Process for continuous cell culture of cancer cells and cancer stem cells
IT201600099380A1 (it) * 2016-10-04 2018-04-04 Univ Bologna Alma Mater Studiorum Composizioni, dispositivi e metodi per il controllo in vitro del microambiente chimico in colture cellulari
EP3523418A4 (en) * 2016-10-06 2020-06-17 Transgenex Nanobiotech, Inc. METHOD FOR THE EXPANSION OF CANCER STEM CELLS (CSC)
EP3534976A4 (en) 2016-11-04 2020-09-16 Children's Hospital Medical Center PATHOLOGICAL MODELS OF HEPATIC ORGANOIDS AND ASSOCIATED METHODS OF MANUFACTURE AND USE
CA3045145A1 (en) 2016-12-05 2018-06-14 Children's Hospital Medical Center Colonic organoids and methods of making and using same
WO2018191673A1 (en) 2017-04-14 2018-10-18 Children's Hospital Medical Center Multi donor stem cell compositions and methods of making same
WO2019006136A1 (en) * 2017-06-28 2019-01-03 Rutgers, The State University Of New Jersey ORGANOIDS DERIVED FROM A SINGLE VESIC CELL
EP3645704A1 (en) * 2017-06-28 2020-05-06 Rutgers, The State University of New Jersey Single lung cell-derived organoids
KR102152492B1 (ko) * 2017-08-14 2020-09-04 울산대학교 산학협력단 3차원 폐암 오가노이드 배양 방법 및 이를 이용한 환자 유래 이종이식 동물모델의 제조 방법
JP7315923B2 (ja) * 2017-09-29 2023-07-27 史敏 石野 臓器オルガノイド及びその製造方法
JP2020536529A (ja) 2017-10-10 2020-12-17 チルドレンズ ホスピタル メディカル センター 食道組織および/または臓器組成物およびそれを作製する方法
GB201721615D0 (en) 2017-12-21 2018-02-07 Koninklijke Nederlandse Akademie Van Wetenschappen Immune cell organoid co-cultures
WO2019126626A1 (en) 2017-12-21 2019-06-27 Children's Hospital Medical Center Digitalized human organoids and methods of using same
WO2019199881A1 (en) * 2018-04-09 2019-10-17 Cedars-Sinai Medical Center Methods for in vitro expansion of adult tissue stem cells
WO2019222559A1 (en) 2018-05-16 2019-11-21 University Of Washington High-throughput automation of organoids for identifying therapeutic strategies
US20210207081A1 (en) * 2018-06-02 2021-07-08 The University Of Hong Kong Mature airway organoids, methods of making and uses thereof
EP3826652B1 (en) 2018-07-26 2026-02-25 Children's Hospital Medical Center Hepato-biliary-pancreatic tissues and methods of making same
EP3849568A4 (en) 2018-09-12 2022-06-15 Children's Hospital Medical Center Organoid compositions for the production of hematopoietic stem cells and derivatives thereof
GB201819224D0 (en) 2018-11-26 2019-01-09 Koninklijke Nederlandse Akademie Van Wetenschappen Hepatocyte expansion methods
GB201903573D0 (en) * 2019-03-15 2019-05-01 Koninklijke Nederlandse Akademie Van Wetenschappen Culture method for head and neck organoids
GB201906978D0 (en) 2019-05-17 2019-07-03 Koninklijke Nederlandse Akademie Van Wetenschappen Improved culture method using integrin agonist
WO2020242256A2 (ko) * 2019-05-29 2020-12-03 연세대학교 산학협력단 인간 미뢰 오가노이드의 배양용 조성물
AU2020283048A1 (en) 2019-05-31 2021-12-23 Children's Hospital Medical Center Shaped organoid compositions and methods of making same
EP3976066A4 (en) 2019-05-31 2023-06-28 Children's Hospital Medical Center Methods of generating and expanding hematopoietic stem cells
WO2021022440A1 (zh) * 2019-08-05 2021-02-11 北京基石生命科技有限公司 肺癌实体瘤原代细胞和肺癌胸腔积液原代肿瘤细胞培养方法及配套试剂
CN110734894B (zh) * 2019-10-11 2021-09-24 纳肽得(青岛)生物医药有限公司 普适性癌症类器官体外培养培养基
KR102292457B1 (ko) * 2019-10-11 2021-08-23 오가노이드사이언스 주식회사 편도 오가노이드의 제조방법 및 이의 용도
EP4048809A4 (en) 2019-10-22 2024-02-14 Tempus Labs, Inc. Systems and methods for predicting therapeutic sensitivity
EP4051782A4 (en) * 2019-10-31 2023-12-06 University Health Network Medium and methods for culturing organoids
CN112779209B (zh) * 2019-11-08 2023-01-24 合肥中科普瑞昇生物医药科技有限公司 原代乳腺上皮细胞培养基、培养方法及其应用
US11629385B2 (en) 2019-11-22 2023-04-18 Tempus Labs, Inc. Tumor organoid culture compositions, systems, and methods
JP2023502785A (ja) * 2019-11-25 2023-01-25 ザ・ペン・ステイト・リサーチ・ファウンデイション ヒトグリア細胞をニューロンに変換するための組成物および方法
JP7744340B2 (ja) 2019-12-05 2025-09-25 テンパス・エーアイ・インコーポレイテッド ハイスループット薬物スクリーニングのためのシステムおよび方法
CN111424015A (zh) * 2019-12-10 2020-07-17 重庆康克唯生物科技有限公司 用于前列腺肿瘤细胞的培养基和三维培养方法
WO2021168199A1 (en) * 2020-02-19 2021-08-26 Trustees Of Boston University Generation of airway basal stem cells from human pluripotent stem cells
EP3884957A1 (en) * 2020-03-26 2021-09-29 The University of British Columbia Methods for treatment of virus and methods for screening of anti-virus reagent using organoids
US11561178B2 (en) 2020-04-20 2023-01-24 Tempus Labs, Inc. Artificial fluorescent image systems and methods
JP7795743B2 (ja) * 2020-05-25 2026-01-08 国立大学法人京都大学 呼吸器オルガノイドの製造方法
EP4159277A4 (en) * 2020-05-27 2024-07-03 Otsuka Pharmaceutical Co., Ltd. METHOD FOR PRODUCING ORGANOID FROM PULMONARY EPITHELIAL CELLS OR PULMONARY CANCER CELLS
KR102282070B1 (ko) * 2020-06-30 2021-07-27 주식회사 인터파크바이오컨버전스 폐 오가노이드 배양용 조성물의 제조 방법, 그 조성물 및 이를 이용한 오가노이드 배양 방법
CN113969262B (zh) * 2020-07-22 2024-03-26 合肥中科普瑞昇生物医药科技有限公司 一种用于肺癌上皮细胞的培养基、培养方法及其应用
CN112592896B (zh) * 2020-11-22 2024-06-25 深圳市第二人民医院(深圳市转化医学研究院) 一种肺腺癌类器官的培养液及其培养方法
CN114763534B (zh) * 2021-01-13 2024-04-26 合肥中科普瑞昇生物医药科技有限公司 原代胃肠间质瘤细胞培养基、培养方法及其应用
CN113186163A (zh) * 2021-01-18 2021-07-30 南昌五元生物科技有限公司 一种基于p53突变筛选肿瘤类器官的培养方法
KR102652944B1 (ko) * 2021-04-14 2024-03-29 연세대학교 산학협력단 섬유화 튜머로이드의 구조를 유지하는 방법
JP7808832B2 (ja) * 2021-04-20 2026-01-30 国立大学法人東京農工大学 ネコ乳腺腫瘍オルガノイド培地用組成物及びネコ乳腺腫瘍オルガノイドの製造方法
US20240376436A1 (en) * 2021-06-14 2024-11-14 Stemcell Technologies Canada Inc. Compositions and methods for biasing the polarity of organoids
WO2023278525A1 (en) * 2021-06-29 2023-01-05 Biomarin Pharmaceutical Inc. Cell culture feed for recombinant adeno-associated virus production in mammalian cells
JP7777322B2 (ja) * 2021-07-01 2025-11-28 国立大学法人東京農工大学 コウモリ組織オルガノイド培地用組成物及びコウモリ組織オルガノイドの製造方法
CN115595308B (zh) * 2021-07-08 2025-10-10 合肥中科普瑞昇生物医药科技有限公司 一种用于肺癌上皮细胞的培养基、培养方法及其应用
GB202109913D0 (en) 2021-07-09 2021-08-25 Stichting Hubrecht Organoid Tech Organoid-derived monolayers and uses thereof
CN113583962B (zh) * 2021-07-30 2023-03-24 新乡医学院 一种诱导培养基及诱导获得癌细胞持续感染ndv的方法
US20240368563A1 (en) * 2021-08-27 2024-11-07 Helmholtz Zentrum München - Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH) In vitro method of invasive and ductal cell growth
US20250019649A1 (en) 2021-11-30 2025-01-16 Université Libre de Bruxelles Generation of thyroid and lung organoids from stem cells
KR20230089159A (ko) * 2021-12-13 2023-06-20 연세대학교 산학협력단 인간 타액선 조직으로부터 분리된 기저 세포 또는 내강 세포 유래 오가노이드의 최적 배양 방법
GB202204266D0 (en) 2022-03-25 2022-05-11 Stichting Hubrecht Organoid Tech Methods for co-culturing genotoxic bacteria and organoids
KR102573391B1 (ko) * 2022-10-05 2023-09-01 오가노이드사이언스 주식회사 침샘 오가노이드 제조용 배지 조성물
WO2024137362A1 (en) 2022-12-21 2024-06-27 Trustees Of Boston University Generation of alveolar epithelial type 1 (at1) cells
CN116179492A (zh) * 2023-03-13 2023-05-30 重庆市人民医院 一种胰腺癌类器官无血清专用培养基
IT202300008076A1 (it) * 2023-04-26 2024-10-26 Irccs Ospedale Policlinico San Martino Terreno di coltura per la propagazione di colture primarie di cellule epiteliali e relativo metodo di utilizzo
EP4495227A1 (en) 2023-07-18 2025-01-22 HUB Organoids IP B.V. Co-cultures of organoids and stromal cells
KR102627833B1 (ko) * 2023-07-18 2024-01-23 엠비디 주식회사 폐암 유래 세포의 3d 배양용 배지 조성물
CN117887688B (zh) * 2024-03-07 2024-06-25 合肥工业大学 一种高活力、高稳定性的脂肪酶突变体及其编码基因和应用

Family Cites Families (76)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2404695A (en) 1994-05-04 1995-11-29 Mount Sinai Hospital Corporation Modulators of cytokines of the tgf-beta superfamily and methods for assaying for same
EP0953633A1 (en) 1998-04-28 1999-11-03 Livercell L.L.C. Cell culturing method and medium for producing proliferated, normal, differentiated human liver cells
AU3859800A (en) 1999-02-24 2000-09-14 Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services, The Artificial salivary gland
US20030003088A1 (en) 2001-05-03 2003-01-02 Board Of Trustees Operating Michigan State University Human pancreatic pluripotential stem cell line
AU2002367580A1 (en) 2001-05-16 2003-09-22 Tracy C. Grikscheit Tissue-engineered organs
AU2002331669A1 (en) 2001-08-23 2003-03-10 The Wistar Institute Of Anatomy And Biology An organotypic intestinal culture and methods of use thereof
WO2003033697A1 (en) 2001-10-18 2003-04-24 Ixion Biotechnology, Inc. Conversion of liver stem and progenitor cells to pancreatic functional cells
US20060040385A1 (en) 2002-12-05 2006-02-23 Technion Research & Development Foundation Ltd. Cultured human pancreatic islets, and uses thereof
WO2004087896A2 (en) 2003-03-31 2004-10-14 Pfizer Products Inc. Hepatocyte differentiation of stem cells
US20040229355A1 (en) 2003-05-14 2004-11-18 Board Of Regents University Of Texas System Culture medium for long-term culture of hepatocytes
US20070010008A1 (en) 2005-06-29 2007-01-11 Tissuetech, Inc. Ex vivo expansion of primary animal cells
WO2005040391A1 (en) * 2003-10-27 2005-05-06 Murdoch Childrens Research Institute Compositions and methods for differentiating stem cells
US20070036769A9 (en) 2004-06-03 2007-02-15 Linheng Li BMP pathway methods and compositions
GB0413005D0 (en) 2004-06-11 2004-07-14 Coletica Ligand
WO2006090882A1 (ja) 2005-02-23 2006-08-31 Foundation For Biomedical Research And Innovation 血管内皮前駆細胞の生体外増幅方法
AU2006202209B2 (en) 2005-05-27 2011-04-14 Lifescan, Inc. Amniotic fluid derived cells
CA2621161A1 (en) 2005-09-08 2007-03-15 The Government Of The United States Of America As Represented By The Sec Retary Of The Department Of Health And Human Services Methods for promoting stem cell proliferation and survival
EP2420565B1 (en) 2006-02-23 2017-08-30 ViaCyte, Inc. Compositions and methods useful for culturing differentiable cells
US7989204B2 (en) 2006-04-28 2011-08-02 Viacyte, Inc. Hepatocyte lineage cells
US8628964B2 (en) 2006-10-11 2014-01-14 Drexel University Fetal pulmonary cells and uses thereof
DK2081586T4 (en) 2006-10-20 2019-01-21 Deutsches Krebsforschungszentrum Stiftung Des Oeffentlichen Rechts Rspondins as modulators of angiogenesis and vasculogenesis
US9251637B2 (en) 2006-11-15 2016-02-02 Bank Of America Corporation Method and apparatus for using at least a portion of a one-time password as a dynamic card verification value
US20080182328A1 (en) 2006-12-19 2008-07-31 The Burnham Institute Mammalian extraembryonic endoderm cells and methods of isolation
US20080233088A1 (en) 2007-02-16 2008-09-25 Varian Medical Systems Technologies, Inc. Preparative regimen for engraftment, growth and differentiation of non-hematopoeitic cells in vivo after transplantation
EP2022848A1 (en) 2007-08-10 2009-02-11 Hubrecht Institut A method for identifying, expanding, and removing adult stem cells and cancer stem cells
CN101918532B (zh) 2007-08-22 2016-03-30 普罗柏欧贞股份公司 用于体外测试免疫原性和免疫功能的培养系统和方法
CN101918542B (zh) * 2007-12-28 2013-06-12 富士瑞必欧株式会社 哺乳动物体细胞用培养基以及该培养基的添加剂
JP2009195142A (ja) 2008-02-20 2009-09-03 Institute Of Physical & Chemical Research 肝臓卵形細胞の取得方法
CN102144163A (zh) * 2008-04-10 2011-08-03 麻省理工学院 关于鉴定和使用靶向癌症干细胞的试剂的方法
EP2138571B1 (en) 2008-06-26 2017-04-12 SpheroTec GmbH Process for the preparation of multicellular spheroids
EP2318520B1 (en) 2008-07-25 2017-10-11 The University Of Georgia Research Foundation, Inc. Compositions for mesoderm derived isl1+ multipotent cells (imps), epicardial progenitor cells (epcs) and multipotent cxcr4+cd56+ cells (c56cs) and methods of use
WO2010016766A2 (en) 2008-08-08 2010-02-11 Koninklijke Nederlandse Akademie Van Wetenschappen Antibodies recognizing endogenous human lgr5 and/or lgr6
US9464275B2 (en) 2008-08-21 2016-10-11 The Board Of Trustees Of The Leland Stanford Junior University Ex vivo culture, proliferation and expansion of intestinal epithelium
US20100100396A1 (en) 2008-10-21 2010-04-22 Monitorx, Llc Medical decision-making tool
GB201111244D0 (en) * 2011-06-30 2011-08-17 Konink Nl Akademie Van Wetenschappen Knaw Culture media for stem cells
EP2412800A1 (en) 2010-07-29 2012-02-01 Koninklijke Nederlandse Akademie van Wetenschappen Liver organoid, uses thereof and culture method for obtaining them
US9752124B2 (en) * 2009-02-03 2017-09-05 Koninklijke Nederlandse Akademie Van Wetenschappen Culture medium for epithelial stem cells and organoids comprising the stem cells
PL3441458T3 (pl) 2009-02-03 2023-11-06 Koninklijke Nederlandse Akademie Van Wetenschappen Podłoże do hodowli nabłonkowych komórek macierzystych i organoidów zawierających wspomniane komórki macierzyste
WO2010108126A2 (en) 2009-03-19 2010-09-23 Fate Therapeutics, Inc. Reprogramming compositions and methods of using the same
EP2420566A4 (en) 2009-04-17 2014-01-15 Univ Tohoku METHOD FOR THE PREPARATION OF HUMAN LUNG STEM CELLS AND METHODS OF DIFFERENTIATING INDUCTION IN HUMAN ALVEOLARY EPITHELIAL CELLS
SG175367A1 (en) * 2009-04-27 2011-11-28 Viacyte Inc Small molecules supporting pluripotent cell growth and methods thereof
WO2016094457A1 (en) 2014-12-08 2016-06-16 Ray Partha S Methods for treating basal-like and claudin-low breast cancer and combination therapies thereof
ES2459122T3 (es) 2010-02-11 2014-05-08 F. Hoffmann-La Roche Ag Ensayo FACS de ADCC de NK en 3D
EP2580320B1 (en) 2010-06-14 2018-08-01 The Scripps Research Institute Reprogramming of cells to a new fate
GB201014169D0 (en) 2010-08-25 2010-10-06 Cambridge Entpr Ltd In vitro hepatic differentiation
SG10201508118WA (en) 2010-09-30 2015-11-27 Agency Science Tech & Res Methods and reagents for detection and treatment of esophageal metaplasia
KR102482184B1 (ko) 2010-12-22 2022-12-28 페이트 세러퓨틱스, 인코포레이티드 단세포 분류 및 iPSC의 증강된 재프로그래밍을 위한 세포 배양 플랫폼
GB201106395D0 (en) 2011-04-14 2011-06-01 Hubrecht Inst Compounds
CN103619168B (zh) * 2011-06-29 2015-09-23 宾州研究基金会 用于治疗白血病的组合物、方法和药盒
US20130052729A1 (en) 2011-08-29 2013-02-28 Olivier Pourquie Method for preparing induced paraxial mesoderm progenitor (ipam) cells and their use
US9663573B2 (en) 2011-10-05 2017-05-30 Genentech, Inc. Methods of treating liver conditions using Notch2 antagonists
GB201117469D0 (en) * 2011-10-10 2011-11-23 Cell Guidance Systems Ltd Culture media for pluripotent stem cells
JP6238445B2 (ja) 2011-10-27 2017-11-29 国立大学法人 東京医科歯科大学 大腸上皮幹細胞の単離・培養技術と、これを用いた大腸上皮移植技術
ES2561604T3 (es) * 2011-12-19 2016-02-29 Umc Utrecht Holding B.V. Un ensayo cuantitativo rápido para medir la función de CFTR en un modelo de cultivo intestinal primario
US20150017134A1 (en) * 2012-03-01 2015-01-15 Whitehead Institute For Biomedical Research Emt-inducing transcription factors cooperate with sox9
CN104508121B (zh) 2012-07-23 2018-01-19 中国科学院生物物理研究所 体外诱导多能干细胞分化为心室肌细胞的方法
WO2014066649A1 (en) * 2012-10-26 2014-05-01 The Regents Of The University Of California A strategy for engineering various 3d tissues, organoids and vasculature
EP2956538B1 (en) 2013-02-13 2018-11-14 Wake Forest University Health Sciences Bioengineered liver constructs and methods relating thereto
WO2014127219A1 (en) 2013-02-14 2014-08-21 The Cleveland Clinic Foundation Methods for induction of cell fates from pluripotent cells
SG11201506520TA (en) 2013-02-18 2015-09-29 Univ Health Network Methods for generating hepatocytes and cholangiocytes from pluripotent stem cells
WO2014159356A1 (en) 2013-03-14 2014-10-02 The Brigham And Women's Hospital, Inc. Compositions and methods for epithelial stem cell expansion and culture
EP4438044A3 (en) * 2013-03-15 2024-12-04 Board of Regents, The University of Texas System Peptide fttftvt for use in treating fibrosis
RU2015148769A (ru) * 2013-04-16 2017-05-23 Орбсен Терапьютикс Лимитед Медицинское применение синдекана-2
US10597633B2 (en) 2014-05-16 2020-03-24 Koninklijke Nederlandse Akademie Van Wetenschappen Culture method for organoids
CA2949673C (en) 2014-05-19 2022-12-13 University Of South Florida Formation of multicellular tumoroids and uses thereof
CN108064274A (zh) 2014-07-30 2018-05-22 耶达研究及发展有限公司 用于培养多能干细胞的培养基
CN107075471A (zh) 2014-10-08 2017-08-18 新加坡科技研究局 将干细胞分化为肝细胞谱系的方法
GB201421092D0 (en) 2014-11-27 2015-01-14 Koninklijke Nederlandse Akademie Van Wetenschappen Culture medium
GB201421094D0 (en) 2014-11-27 2015-01-14 Koninklijke Nederlandse Akademie Van Wetenschappen Culture medium
WO2016205331A1 (en) 2015-06-15 2016-12-22 Texas Tech University System Targeted-delivery of small interference rna against anthrax
CN110582564A (zh) 2015-09-15 2019-12-17 新加坡科技研究局 从人类多能干细胞衍生肝类器官
CN106754636B (zh) 2015-11-19 2019-08-30 中国人民解放军第二军医大学 体外诱导原代肝细胞胆管化并长期培养、扩增和分化的方法及其应用
GB201603569D0 (en) 2016-03-01 2016-04-13 Koninklijke Nederlandse Akademie Van Wetenschappen Improved differentiation method
EP3936610A1 (en) 2016-05-25 2022-01-12 Salk Institute for Biological Studies Compositions and methods for organoid generation and disease modeling
GB201610748D0 (en) 2016-06-20 2016-08-03 Koninklijke Nederlandse Akademie Van Wetenschappen Improved diffrentation method
GB201721615D0 (en) 2017-12-21 2018-02-07 Koninklijke Nederlandse Akademie Van Wetenschappen Immune cell organoid co-cultures

Similar Documents

Publication Publication Date Title
JP2022028828A5 (enExample)
JP2022025124A5 (enExample)
JP2021185136A5 (enExample)
JP2021169491A5 (enExample)
JP2022068302A5 (enExample)
JP2021028398A5 (enExample)
JP2023116721A5 (enExample)
JP2021038271A5 (enExample)
JP2023022224A5 (enExample)
JP2021184963A5 (enExample)
JP2024059739A5 (enExample)
JP2021151238A5 (enExample)
JP2020042034A5 (enExample)
JP2020127428A5 (enExample)
JP2024016014A5 (enExample)
JP2019099571A5 (enExample)
JP2019030304A5 (enExample)
JP2021502066A5 (enExample)
JP2020530297A5 (enExample)
JP2022060295A5 (enExample)
JP2023100643A5 (enExample)
JP2019031552A5 (enExample)
JP2018154848A5 (enExample)
JP2020120660A5 (enExample)
JP2020171301A5 (enExample)