JP2021518389A5 - - Google Patents
Info
- Publication number
- JP2021518389A5 JP2021518389A5 JP2020550632A JP2020550632A JP2021518389A5 JP 2021518389 A5 JP2021518389 A5 JP 2021518389A5 JP 2020550632 A JP2020550632 A JP 2020550632A JP 2020550632 A JP2020550632 A JP 2020550632A JP 2021518389 A5 JP2021518389 A5 JP 2021518389A5
- Authority
- JP
- Japan
- Prior art keywords
- invention described
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862646432P | 2018-03-22 | 2018-03-22 | |
| US62/646,432 | 2018-03-22 | ||
| PCT/US2019/023111 WO2019183186A1 (en) | 2018-03-22 | 2019-03-20 | Heterocyclic compounds comprising pyridine useful as modulators of il-12, il-23 and/or ifn alpha responses |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2021518389A JP2021518389A (ja) | 2021-08-02 |
| JP2021518389A5 true JP2021518389A5 (enExample) | 2022-03-31 |
| JP7485609B2 JP7485609B2 (ja) | 2024-05-16 |
Family
ID=66001366
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020550632A Active JP7485609B2 (ja) | 2018-03-22 | 2019-03-20 | ＩＬ－１２、ＩＬ－２３および／またはＩＦＮα応答のモジュレーターとして有用なピリジン含有ヘテロ環式化合物 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US11597721B2 (enExample) |
| EP (1) | EP3768667B1 (enExample) |
| JP (1) | JP7485609B2 (enExample) |
| KR (1) | KR102741437B1 (enExample) |
| CN (1) | CN111936486B (enExample) |
| ES (1) | ES2944733T3 (enExample) |
| WO (1) | WO2019183186A1 (enExample) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR102858043B1 (ko) * | 2018-10-30 | 2025-09-10 | 브리스톨-마이어스 스큅 컴퍼니 | Il-12, il-23 및/또는 ifn-알파의 조정과 관련된 상태의 치료를 위한 아미드-치환된 헤테로시클릭 화합물 |
| BR112021013924A2 (pt) | 2019-01-18 | 2021-09-21 | Astrazeneca Ab | Inibidores de pcsk9 e métodos de uso do mesmo |
| WO2020150473A2 (en) | 2019-01-18 | 2020-07-23 | Dogma Therapeutics, Inc. | Pcsk9 inhibitors and methods of use thereof |
| ES2981764T3 (es) * | 2020-03-11 | 2024-10-10 | Beijing Innocare Pharma Tech Co Ltd | Compuestos heterocíclicos para inhibir las actividades de TYK2 |
| US20230295119A1 (en) | 2020-04-14 | 2023-09-21 | Gossamer Bio Services, Inc. | Substituted pyridines for the treatment of inflammatory diseases |
| CN122520625A (zh) | 2020-12-22 | 2026-08-07 | 益方生物科技(上海)股份有限公司 | 杂芳基化合物及其制备方法和用途 |
| EP4308556A4 (en) | 2021-03-16 | 2025-02-19 | Anrui Biomedical Technology (Guangzhou) Co., Ltd. | Amino heteroaryl compounds and compositions |
| CN115141149A (zh) * | 2021-03-30 | 2022-10-04 | 浙江文达医药科技有限公司 | 作为tyk2假激酶结构域抑制剂的杂环化合物及合成方法和用途 |
| CN116888125B (zh) * | 2021-04-07 | 2024-04-12 | 上海齐鲁制药研究中心有限公司 | Tyk2抑制剂及其用途 |
| JP7740849B2 (ja) * | 2021-05-04 | 2025-09-17 | シャンハイ ゼイ バイオテクノロジー カンパニー リミテッド | 含窒素複素環ピリジン化合物 |
| US20240317718A1 (en) * | 2021-05-14 | 2024-09-26 | Bristol-Myers Squibb Company | Substituted heterocyclic compounds |
| CA3223641A1 (en) * | 2021-06-22 | 2022-12-29 | Wenyuan Qian | Sulfoximine compound and use thereof |
| CN117794911A (zh) * | 2021-07-15 | 2024-03-29 | 南京明德新药研发有限公司 | 含硫/磷的芳基类化合物及其应用 |
| WO2023027948A1 (en) * | 2021-08-21 | 2023-03-02 | Relay Therapeutics, Inc. | Jak2 inhibitors and methods of use thereof |
| WO2023064223A1 (en) | 2021-10-11 | 2023-04-20 | Gossamer Bio Services, Inc. | Tri-substituted pyridines |
| KR20240111312A (ko) | 2021-10-25 | 2024-07-16 | 카이메라 쎄라퓨틱스 인코포레이티드 | Tyk2 분해제 및 이의 용도 |
| TW202339749A (zh) * | 2021-12-16 | 2023-10-16 | 大陸商凌科藥業有限公司 | Ｔｙｋ２抑制劑及其組合物和方法 |
| EP4206196A1 (en) | 2021-12-29 | 2023-07-05 | Almirall S.A. | Pyrimidine substituted derivatives as tyk2 inhibitors |
| CN117263913A (zh) | 2022-06-20 | 2023-12-22 | 益方生物科技(上海)股份有限公司 | 杂芳基化合物、固体形式、制备方法及其用途 |
| WO2024020221A1 (en) * | 2022-07-21 | 2024-01-25 | Arvinas Operations, Inc. | Modulators of tyk2 proteolysis and associated methods of use |
| AU2023412260A1 (en) * | 2022-12-22 | 2025-05-29 | Usynova Pharmaceuticals Ltd. | Salt form and crystal form of pyridine multi-substituted compound and preparation method therefor |
| CN120607493B (zh) * | 2025-06-04 | 2026-04-24 | 江西科技师范大学 | 一种含嘧啶结构的酰胺类化合物及其在制备tyk2 jh2激酶抑制剂中的应用 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8987456B2 (en) | 2011-10-05 | 2015-03-24 | Merck Sharp & Dohme Corp. | 3-pyridyl carboxamide-containing spleen tyrosine kinase (SYK) inhibitors |
| KR20140108594A (ko) | 2012-01-10 | 2014-09-11 | 에프. 호프만-라 로슈 아게 | 피리다진 아미드 화합물 및 syk 저해제로서의 이의 용도 |
| EP2922841B8 (en) | 2012-11-08 | 2017-08-02 | Bristol-Myers Squibb Company | Alkyl-amide-substituted pyridyl compounds useful as modulators of il-12, il-23 and/or ifn alpha responses |
| HRP20220766T1 (hr) | 2012-11-08 | 2022-09-16 | Bristol-Myers Squibb Company | Amidom-supstituirani heterociklički spojevi korisni kao modulatori il-12, il-23 i/ili ifn alfa odgovora |
| MA48602A (fr) | 2016-12-13 | 2020-03-18 | Bristol Myers Squibb Co | Composés hétéroaryle substitués par un amide alkyle d'oxyde de phosphine en tant que modulateurs des réponses il-12, il-23 et/ou ifn alpha |
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2019
- 2019-03-20 JP JP2020550632A patent/JP7485609B2/ja active Active
- 2019-03-20 ES ES19715330T patent/ES2944733T3/es active Active
- 2019-03-20 WO PCT/US2019/023111 patent/WO2019183186A1/en not_active Ceased
- 2019-03-20 US US16/982,937 patent/US11597721B2/en active Active
- 2019-03-20 KR KR1020207029906A patent/KR102741437B1/ko active Active
- 2019-03-20 EP EP19715330.7A patent/EP3768667B1/en active Active
- 2019-03-20 CN CN201980020946.5A patent/CN111936486B/zh active Active