JP7319027B2 - 培養培地 - Google Patents

培養培地 Download PDF

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JP7319027B2
JP7319027B2 JP2017528087A JP2017528087A JP7319027B2 JP 7319027 B2 JP7319027 B2 JP 7319027B2 JP 2017528087 A JP2017528087 A JP 2017528087A JP 2017528087 A JP2017528087 A JP 2017528087A JP 7319027 B2 JP7319027 B2 JP 7319027B2
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culture medium
organoids
cells
lung
cell
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JP2018503360A (ja
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ラース ノーマン ザックス
ヤルノ ドロスト
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Koninklijke Nederlandse Akademie van Wetenschappen
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Koninklijke Nederlandse Akademie van Wetenschappen
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    • C—CHEMISTRY; METALLURGY
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0662—Stem cells
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    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0693—Tumour cells; Cancer cells
    • C12N5/0695—Stem cells; Progenitor cells; Precursor cells
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/13—Tumour cells, irrespective of tissue of origin
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/42—Respiratory system, e.g. lungs, bronchi or lung cells
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
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    • C12N5/0623—Stem cells
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    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0625—Epidermal cells, skin cells; Cells of the oral mucosa
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    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0625—Epidermal cells, skin cells; Cells of the oral mucosa
    • C12N5/0629—Keratinocytes; Whole skin
    • C12N5/063—Kereatinocyte stem cells; Keratinocyte progenitors
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    • C12N5/0602—Vertebrate cells
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    • C12N5/0697—Artificial constructs associating cells of different lineages, e.g. tissue equivalents
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    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
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    • G01N33/502—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects
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    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
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    • G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
    • G01N33/5073—Stem cells
    • G—PHYSICS
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    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
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    • C12N2501/13—Nerve growth factor [NGF]; Brain-derived neurotrophic factor [BDNF]; Cilliary neurotrophic factor [CNTF]; Glial-derived neurotrophic factor [GDNF]; Neurotrophins [NT]; Neuregulins
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JP2017528087A 2014-11-27 2015-11-27 培養培地 Active JP7319027B2 (ja)

Priority Applications (2)

Application Number Priority Date Filing Date Title
JP2021187540A JP2022028828A (ja) 2014-11-27 2021-11-18 培養培地
JP2023197836A JP2024016281A (ja) 2014-11-27 2023-11-22 培養培地

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
GBGB1421092.6A GB201421092D0 (en) 2014-11-27 2014-11-27 Culture medium
GB1421092.6 2014-11-27
GB1507834.8 2015-05-07
GB1507834.8A GB2532814A (en) 2014-11-27 2015-05-07 Culture medium
PCT/EP2015/077990 WO2016083613A2 (en) 2014-11-27 2015-11-27 Culture medium

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JP2021187540A Division JP2022028828A (ja) 2014-11-27 2021-11-18 培養培地

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JP2018503360A JP2018503360A (ja) 2018-02-08
JP7319027B2 true JP7319027B2 (ja) 2023-08-01

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JP2017528087A Active JP7319027B2 (ja) 2014-11-27 2015-11-27 培養培地
JP2021187540A Pending JP2022028828A (ja) 2014-11-27 2021-11-18 培養培地
JP2023197836A Pending JP2024016281A (ja) 2014-11-27 2023-11-22 培養培地

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JP2023197836A Pending JP2024016281A (ja) 2014-11-27 2023-11-22 培養培地

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US (2) US11130943B2 (enExample)
EP (1) EP3224346A2 (enExample)
JP (3) JP7319027B2 (enExample)
AU (3) AU2015352351B2 (enExample)
CA (1) CA2968736A1 (enExample)
GB (2) GB201421092D0 (enExample)
HK (1) HK1245323A1 (enExample)
WO (1) WO2016083613A2 (enExample)

Families Citing this family (73)

* Cited by examiner, † Cited by third party
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EP3061808B1 (en) 2009-02-03 2020-08-12 Koninklijke Nederlandse Akademie van Wetenschappen Culture medium for epithelial stem cells and organoids comprising said stem cells
EP2412800A1 (en) 2010-07-29 2012-02-01 Koninklijke Nederlandse Akademie van Wetenschappen Liver organoid, uses thereof and culture method for obtaining them
WO2011140441A2 (en) 2010-05-06 2011-11-10 Children's Hospital Medical Center Methods and systems for converting precursor cells into intestinal tissues through directed differentiation
BR112014014756B1 (pt) 2011-12-19 2022-12-06 Koninklijke Nederlandse Akademie Van Wetenschappen Método in vitro, e, uso in vitro de um ou mais organoides
AU2015261380B2 (en) 2014-05-16 2021-04-15 Koninklijke Nederlandse Akademie Van Wetenschappen Improved culture method for organoids
JP6687544B2 (ja) 2014-05-28 2020-04-22 チルドレンズ ホスピタル メディカル センター 前駆細胞を指向性分化によって胃組織に変換するための方法及びシステム
US11584916B2 (en) 2014-10-17 2023-02-21 Children's Hospital Medical Center Method of making in vivo human small intestine organoids from pluripotent stem cells
GB201421092D0 (en) 2014-11-27 2015-01-14 Koninklijke Nederlandse Akademie Van Wetenschappen Culture medium
GB201421094D0 (en) 2014-11-27 2015-01-14 Koninklijke Nederlandse Akademie Van Wetenschappen Culture medium
GB201603569D0 (en) 2016-03-01 2016-04-13 Koninklijke Nederlandse Akademie Van Wetenschappen Improved differentiation method
CN109415685B (zh) 2016-05-05 2023-07-04 儿童医院医疗中心 用于体外制造胃底组织的方法和与其相关的组合物
GB201611982D0 (en) 2016-07-11 2016-08-24 Cellesce Ltd Cell culture
US20190161737A1 (en) * 2016-07-27 2019-05-30 Georgetown University Process for continuous cell culture of cancer cells and cancer stem cells
IT201600099380A1 (it) * 2016-10-04 2018-04-04 Univ Bologna Alma Mater Studiorum Composizioni, dispositivi e metodi per il controllo in vitro del microambiente chimico in colture cellulari
WO2018067925A1 (en) * 2016-10-06 2018-04-12 Transgenex Nanobiotech, Inc. Methods for cancer stem cell (csc) expansion
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ＩＮ ＶＩＴＲＯ，１９８０年，Ｖｏｌ．１６，Ｎｏ．１１，ｐ．９９４－１００６
Ｌｅｊｌａ Ｐａｓｉｃ ｅｔ ａｌ．，Ｓｕｓｔａｉｎｅｄ ａｃｔｉｖａｔｉｏｎ ｏｆ ｔｈｅ ＨＥＲ１－ＥＲＫ１／２－ＲＳＫ ｓｉｇｎａｌｉｎｇ ｐａｔｈｗａｙ ｃｏｎｔｒｏｌｓ ｍｙｏｅｐｉｔｈｅｌｉａｌ ｃｅｌｌ ｆａｔｅ ｉｎ ｈｕｍａｎ ｍａｍｍａｒｙ ｔｉｓｓｕｅ，ＧＥＮＥＳ ＆ ＤＥＶＥＬＯＰＭＥＮＴ，２０１１年，Ｖｏｌ．２５， ｐ．１６４１－１６５３
Ｍｏｌｅｃｕｌａｒ ａｎｄ Ｃｅｌｌｕｌａｒ Ｂｉｏｃｈｅｍｉｓｔｒｙ，２００７年，Ｖｏｌ．３０５，ｐ．１７１－１７８

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