HUE041584T2 - Célzott genetikai módosítások és alkalmazási módszerek és készítmények - Google Patents
Célzott genetikai módosítások és alkalmazási módszerek és készítményekInfo
- Publication number
- HUE041584T2 HUE041584T2 HUE15745288A HUE15745288A HUE041584T2 HU E041584 T2 HUE041584 T2 HU E041584T2 HU E15745288 A HUE15745288 A HU E15745288A HU E15745288 A HUE15745288 A HU E15745288A HU E041584 T2 HUE041584 T2 HU E041584T2
- Authority
- HU
- Hungary
- Prior art keywords
- methods
- compositions
- genetic modifications
- targeted genetic
- targeted
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0603—Embryonic cells ; Embryoid bodies
- C12N5/0606—Pluripotent embryonic cells, e.g. embryonic stem cells [ES]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New breeds of animals
- A01K67/027—New breeds of vertebrates
- A01K67/0275—Genetically modified vertebrates, e.g. transgenic
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New breeds of animals
- A01K67/027—New breeds of vertebrates
- A01K67/0275—Genetically modified vertebrates, e.g. transgenic
- A01K67/0276—Knockout animals
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New breeds of animals
- A01K67/027—New breeds of vertebrates
- A01K67/0275—Genetically modified vertebrates, e.g. transgenic
- A01K67/0278—Humanized animals, e.g. knockin
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
- C12N15/90—Stable introduction of foreign DNA into chromosome
- C12N15/902—Stable introduction of foreign DNA into chromosome using homologous recombination
- C12N15/907—Stable introduction of foreign DNA into chromosome using homologous recombination in mammalian cells
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/07—Animals genetically altered by homologous recombination
- A01K2217/075—Animals genetically altered by homologous recombination inducing loss of function, i.e. knock out
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2227/00—Animals characterised by species
- A01K2227/10—Mammal
- A01K2227/105—Murine
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/02—Animal zootechnically ameliorated
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/03—Animal model, e.g. for test or diseases
- A01K2267/0393—Animal model comprising a reporter system for screening tests
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/20—Type of nucleic acid involving clustered regularly interspaced short palindromic repeats [CRISPRs]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2500/00—Specific components of cell culture medium
- C12N2500/60—Buffer, e.g. pH regulation, osmotic pressure
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2517/00—Cells related to new breeds of animals
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201462017582P | 2014-06-26 | 2014-06-26 | |
US201462017627P | 2014-06-26 | 2014-06-26 |
Publications (1)
Publication Number | Publication Date |
---|---|
HUE041584T2 true HUE041584T2 (hu) | 2019-05-28 |
Family
ID=53773509
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HUE15745288A HUE041584T2 (hu) | 2014-06-26 | 2015-06-26 | Célzott genetikai módosítások és alkalmazási módszerek és készítmények |
Country Status (23)
Country | Link |
---|---|
US (4) | US9902971B2 (hu) |
EP (2) | EP3161128B1 (hu) |
JP (2) | JP6752158B2 (hu) |
KR (2) | KR102386101B1 (hu) |
CN (2) | CN107002093B (hu) |
AU (2) | AU2015279642B2 (hu) |
CA (2) | CA2953559C (hu) |
CY (1) | CY1120808T1 (hu) |
DK (1) | DK3161128T3 (hu) |
ES (2) | ES2694629T3 (hu) |
HR (1) | HRP20181630T1 (hu) |
HU (1) | HUE041584T2 (hu) |
IL (1) | IL249637B (hu) |
LT (1) | LT3161128T (hu) |
MX (2) | MX2016017317A (hu) |
PL (1) | PL3161128T3 (hu) |
PT (1) | PT3161128T (hu) |
RS (1) | RS58009B1 (hu) |
RU (2) | RU2711740C2 (hu) |
SG (2) | SG10201911411YA (hu) |
SI (1) | SI3161128T1 (hu) |
TR (1) | TR201816074T4 (hu) |
WO (1) | WO2015200805A2 (hu) |
Families Citing this family (64)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2011002988A1 (en) | 2009-07-01 | 2011-01-06 | Transposagen Biopharmaceuticals, Inc. | Genetically modified rat models for severe combined immunodeficiency (scid) |
JP2013528062A (ja) | 2010-06-11 | 2013-07-08 | リジェネロン・ファーマシューティカルズ・インコーポレイテッド | Xyes細胞からの繁殖可能なxy雌動物の生成 |
EP3613852A3 (en) | 2011-07-22 | 2020-04-22 | President and Fellows of Harvard College | Evaluation and improvement of nuclease cleavage specificity |
SG10201702445TA (en) | 2012-04-25 | 2017-04-27 | Regeneron Pharma | Nuclease-mediated targeting with large targeting vectors |
WO2014130706A1 (en) | 2013-02-20 | 2014-08-28 | Regeneron Pharmaceuticals, Inc. | Genetic modification of rats |
LT3456831T (lt) | 2013-04-16 | 2021-09-10 | Regeneron Pharmaceuticals, Inc. | Tikslinis žiurkės genomo modifikavimas |
US20150044192A1 (en) | 2013-08-09 | 2015-02-12 | President And Fellows Of Harvard College | Methods for identifying a target site of a cas9 nuclease |
US9359599B2 (en) | 2013-08-22 | 2016-06-07 | President And Fellows Of Harvard College | Engineered transcription activator-like effector (TALE) domains and uses thereof |
US9322037B2 (en) | 2013-09-06 | 2016-04-26 | President And Fellows Of Harvard College | Cas9-FokI fusion proteins and uses thereof |
US9340799B2 (en) | 2013-09-06 | 2016-05-17 | President And Fellows Of Harvard College | MRNA-sensing switchable gRNAs |
US9737604B2 (en) | 2013-09-06 | 2017-08-22 | President And Fellows Of Harvard College | Use of cationic lipids to deliver CAS9 |
WO2015088643A1 (en) | 2013-12-11 | 2015-06-18 | Regeneron Pharmaceuticals, Inc. | Methods and compositions for the targeted modification of a genome |
US20150166982A1 (en) | 2013-12-12 | 2015-06-18 | President And Fellows Of Harvard College | Methods for correcting pi3k point mutations |
ES2784754T3 (es) | 2014-06-06 | 2020-09-30 | Regeneron Pharma | Métodos y composiciones para modificar un locus objetivo |
SI3161128T1 (sl) | 2014-06-26 | 2019-02-28 | Regeneron Pharmaceuticals, Inc. | Postopki in sestavki za ciljano genetsko spremembo in postopki uporabe |
WO2016022363A2 (en) | 2014-07-30 | 2016-02-11 | President And Fellows Of Harvard College | Cas9 proteins including ligand-dependent inteins |
EP3561052A1 (en) | 2014-10-15 | 2019-10-30 | Regeneron Pharmaceuticals, Inc. | Methods and compositions for generating or maintaining pluripotent cells |
RS58893B1 (sr) | 2014-11-21 | 2019-08-30 | Regeneron Pharma | Postupci i kompozicije za ciljanu genetičku modifikaciju korišćenjem parnih vodećih rnk |
CN107208113A (zh) | 2014-12-19 | 2017-09-26 | 瑞泽恩制药公司 | 用于通过单步多重靶向进行靶向遗传修饰的方法和组合物 |
JP6619822B2 (ja) | 2015-05-29 | 2019-12-11 | リジェネロン・ファーマシューティカルズ・インコーポレイテッドRegeneron Pharmaceuticals, Inc. | C9orf72遺伝子座における破壊を有する非ヒト動物 |
AU2016324305B2 (en) * | 2015-09-17 | 2022-03-03 | Regeneron Pharmaceuticals, Inc. | Selection of pluripotent cells for production of fertile XY female mice |
JP7109784B2 (ja) | 2015-10-23 | 2022-08-01 | プレジデント アンド フェローズ オブ ハーバード カレッジ | 遺伝子編集のための進化したCas9蛋白質 |
CN116458475A (zh) | 2016-06-03 | 2023-07-21 | 瑞泽恩制药公司 | 表达外源末端脱氧核苷酸转移酶的非人动物 |
KR20190041476A (ko) | 2016-07-29 | 2019-04-22 | 리제너론 파마슈티칼스 인코포레이티드 | C-절단된 피브릴린-1의 발현을 유도하는 돌연변이를 포함하는 마우스 |
WO2018027078A1 (en) | 2016-08-03 | 2018-02-08 | President And Fellows Of Harard College | Adenosine nucleobase editors and uses thereof |
US11661590B2 (en) | 2016-08-09 | 2023-05-30 | President And Fellows Of Harvard College | Programmable CAS9-recombinase fusion proteins and uses thereof |
US11542509B2 (en) | 2016-08-24 | 2023-01-03 | President And Fellows Of Harvard College | Incorporation of unnatural amino acids into proteins using base editing |
SG10202102997UA (en) | 2016-09-30 | 2021-04-29 | Regeneron Pharma | Non-human animals having a hexanucleotide repeat expansion in a c9orf72 locus |
WO2018071868A1 (en) | 2016-10-14 | 2018-04-19 | President And Fellows Of Harvard College | Aav delivery of nucleobase editors |
WO2018119359A1 (en) | 2016-12-23 | 2018-06-28 | President And Fellows Of Harvard College | Editing of ccr5 receptor gene to protect against hiv infection |
CA3049138A1 (en) | 2017-01-20 | 2018-07-26 | Regeneron Pharmaceuticals, Inc. | Rotatable surgical table |
TW201839136A (zh) | 2017-02-06 | 2018-11-01 | 瑞士商諾華公司 | 治療血色素異常症之組合物及方法 |
WO2018165504A1 (en) | 2017-03-09 | 2018-09-13 | President And Fellows Of Harvard College | Suppression of pain by gene editing |
KR20190127797A (ko) | 2017-03-10 | 2019-11-13 | 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 | 시토신에서 구아닌으로의 염기 편집제 |
CA3057192A1 (en) | 2017-03-23 | 2018-09-27 | President And Fellows Of Harvard College | Nucleobase editors comprising nucleic acid programmable dna binding proteins |
WO2018195129A1 (en) | 2017-04-17 | 2018-10-25 | University Of Maryland, College Park | Embryonic cell cultures and methods of using the same |
US11560566B2 (en) | 2017-05-12 | 2023-01-24 | President And Fellows Of Harvard College | Aptazyme-embedded guide RNAs for use with CRISPR-Cas9 in genome editing and transcriptional activation |
WO2019014489A1 (en) * | 2017-07-12 | 2019-01-17 | Mayo Foundation For Medical Education And Research | MATERIALS AND METHODS FOR EFFICIENT TARGETED KNOCK-IN OR GENE REPLACEMENT |
US11732274B2 (en) | 2017-07-28 | 2023-08-22 | President And Fellows Of Harvard College | Methods and compositions for evolving base editors using phage-assisted continuous evolution (PACE) |
MX2020001178A (es) | 2017-07-31 | 2020-09-25 | Regeneron Pharma | Celulas madre embrionarias de raton transgenico con cas y ratones y usos de los mismos. |
JP2020533957A (ja) | 2017-07-31 | 2020-11-26 | リジェネロン・ファーマシューティカルズ・インコーポレイテッドRegeneron Pharmaceuticals, Inc. | Crisprリポーター非ヒト動物およびその使用 |
US11319532B2 (en) | 2017-08-30 | 2022-05-03 | President And Fellows Of Harvard College | High efficiency base editors comprising Gam |
EP3688161A1 (en) | 2017-09-29 | 2020-08-05 | Intellia Therapeutics, Inc. | Compositions and methods for ttr gene editing and treating attr amyloidosis |
CA3082251A1 (en) | 2017-10-16 | 2019-04-25 | The Broad Institute, Inc. | Uses of adenosine base editors |
WO2019103982A2 (en) * | 2017-11-21 | 2019-05-31 | The Regents Of The University Of California | Endonuclease sexing and sterilization in insects |
CN116064611A (zh) | 2017-11-30 | 2023-05-05 | 瑞泽恩制药公司 | 包含人源化trkb基因座的非人动物 |
CA3089331A1 (en) | 2018-03-19 | 2019-09-26 | Regeneron Pharmaceuticals, Inc. | Transcription modulation in animals using crispr/cas systems |
KR20210105914A (ko) | 2018-12-20 | 2021-08-27 | 리제너론 파마슈티칼스 인코포레이티드 | 뉴클레아제-매개 반복부 팽창 |
WO2020131986A1 (en) * | 2018-12-21 | 2020-06-25 | Pioneer Hi-Bred International, Inc. | Multiplex genome targeting |
CN109679997A (zh) * | 2018-12-28 | 2019-04-26 | 佛山科学技术学院 | 控制猪只性别的育种方法、种公猪克隆细胞构建方法及应用 |
KR20210141522A (ko) * | 2019-03-18 | 2021-11-23 | 리제너론 파마슈티칼스 인코포레이티드 | 타우 시딩 또는 응집의 유전적 변형제를 식별하기 위한 CRISPR/Cas 스크리닝 플랫폼 |
MX2021011426A (es) | 2019-03-19 | 2022-03-11 | Broad Inst Inc | Metodos y composiciones para editar secuencias de nucleótidos. |
SG11202108454RA (en) | 2019-04-04 | 2021-09-29 | Regeneron Pharma | Non-human animals comprising a humanized coagulation factor 12 locus |
EP3801011A1 (en) | 2019-06-04 | 2021-04-14 | Regeneron Pharmaceuticals, Inc. | Non-human animals comprising a humanized ttr locus with a beta-slip mutation and methods of use |
CN113939595A (zh) | 2019-06-07 | 2022-01-14 | 瑞泽恩制药公司 | 包括人源化白蛋白基因座的非人动物 |
CA3169272A1 (en) | 2020-01-28 | 2021-08-05 | Regeneron Pharmaceuticals, Inc. | Non-human animals comprising a humanized pnpla3 locus and methods of use |
EP4099821A1 (en) | 2020-02-07 | 2022-12-14 | Regeneron Pharmaceuticals, Inc. | <smallcaps/>? ? ?klkb1? ? ? ? ?non-human animals comprising a humanizedlocus and methods of use |
CN113355323B (zh) * | 2020-03-06 | 2023-07-11 | 生物岛实验室 | 人源化ace2基因改造小鼠模型的制备方法及应用 |
CN113355325B (zh) * | 2020-03-06 | 2023-07-14 | 中国科学院广州生物医药与健康研究院 | 人源化ace2基因改造小鼠胚胎干细胞模型制备方法及应用 |
WO2021195079A1 (en) | 2020-03-23 | 2021-09-30 | Regeneron Pharmaceuticals, Inc. | Non-human animals comprising a humanized ttr locus comprising a v30m mutation and methods of use |
IL297761A (en) | 2020-05-08 | 2022-12-01 | Broad Inst Inc | Methods and compositions for simultaneously editing two helices of a designated double-helix nucleotide sequence |
CN113558012A (zh) * | 2021-08-05 | 2021-10-29 | 陈米米 | 一种哺乳动物繁育雌性多胎的方法 |
WO2023108047A1 (en) | 2021-12-08 | 2023-06-15 | Regeneron Pharmaceuticals, Inc. | Mutant myocilin disease model and uses thereof |
CN116064755B (zh) * | 2023-01-12 | 2023-10-20 | 华中科技大学同济医学院附属同济医院 | 一种基于连锁基因突变检测mrd标志物的装置 |
Family Cites Families (104)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US45375A (en) | 1864-12-06 | Improvement in coal-oil burners | ||
WO1992000375A1 (en) * | 1990-06-28 | 1992-01-09 | Imperial Cancer Research Technology Ltd. | Sex determining gene |
US5830729A (en) | 1996-04-18 | 1998-11-03 | Institut Pasteur | I Sce I-induced gene replacement and gene conversion in embryonic stem cells |
JP2000508919A (ja) | 1996-04-29 | 2000-07-18 | リューベン・リサーチ・アンド・デベロップメント・ベー・ゼット・ウェー | 多能性ウサギ胚幹(es)細胞系およびそのキメラウサギの発生における使用 |
WO1999005266A2 (en) | 1997-07-26 | 1999-02-04 | Wisconsin Alumni Research Foundation | Trans-species nuclear transfer |
CA2354542A1 (en) | 1998-12-31 | 2000-07-06 | The J. David Gladstone Institutes | Transgenic rodents and rodent cell lines expressing hiv co-receptors |
US6599692B1 (en) | 1999-09-14 | 2003-07-29 | Sangamo Bioscience, Inc. | Functional genomics using zinc finger proteins |
US20030104526A1 (en) | 1999-03-24 | 2003-06-05 | Qiang Liu | Position dependent recognition of GNN nucleotide triplets by zinc fingers |
WO2001040798A2 (en) | 1999-12-06 | 2001-06-07 | Sangamo Biosciences, Inc. | Methods of using randomized libraries of zinc finger proteins for the identification of gene function |
CA2394812A1 (en) | 1999-12-20 | 2001-06-28 | Anthony C.F. Perry | A method to produce cloned embryos and adults from cultured cells |
US6586251B2 (en) | 2000-10-31 | 2003-07-01 | Regeneron Pharmaceuticals, Inc. | Methods of modifying eukaryotic cells |
US6596541B2 (en) | 2000-10-31 | 2003-07-22 | Regeneron Pharmaceuticals, Inc. | Methods of modifying eukaryotic cells |
US20050144655A1 (en) | 2000-10-31 | 2005-06-30 | Economides Aris N. | Methods of modifying eukaryotic cells |
US7105348B2 (en) | 2000-10-31 | 2006-09-12 | Regeneron Pharmaceuticals, Inc. | Methods of modifying eukaryotic cells |
JP2004537260A (ja) | 2000-12-07 | 2004-12-16 | サンガモ バイオサイエンシーズ, インコーポレイテッド | ジンクフィンガータンパク質による血管新生の調節 |
CA2435394C (en) | 2001-01-22 | 2018-01-09 | Sangamo Biosciences, Inc. | Modified zinc finger binding proteins |
WO2002057308A2 (en) | 2001-01-22 | 2002-07-25 | Sangamo Biosciences, Inc. | Zinc finger polypeptides and their use |
AUPR451401A0 (en) | 2001-04-20 | 2001-05-24 | Monash University | A method of nuclear transfer |
US8106255B2 (en) | 2002-01-23 | 2012-01-31 | Dana Carroll | Targeted chromosomal mutagenasis using zinc finger nucleases |
CN1649489A (zh) | 2002-02-27 | 2005-08-03 | 长尾恭光 | 一种制备种系嵌合动物的方法 |
WO2003073843A2 (en) * | 2002-03-05 | 2003-09-12 | Artemis Pharmaceuticals Gmbh | Inbred embryonic stem-cell derived mice |
US8206965B2 (en) | 2002-03-15 | 2012-06-26 | Cellectis S.A. | Hybrid and single chain meganucleases and use thereof |
AU2003218382B2 (en) | 2002-03-21 | 2007-12-13 | Sangamo Therapeutics, Inc. | Methods and compositions for using zinc finger endonucleases to enhance homologous recombination |
US7612250B2 (en) | 2002-07-29 | 2009-11-03 | Trustees Of Tufts College | Nuclear transfer embryo formation method |
AU2003298574B2 (en) | 2002-09-05 | 2008-04-24 | California Institute Of Technology | Use of chimeric nucleases to stimulate gene targeting |
AU2003290518A1 (en) | 2002-09-06 | 2004-04-23 | Fred Hutchinson Cancer Research Center | Methods and compositions concerning designed highly-specific nucleic acid binding proteins |
US20030175968A1 (en) | 2002-10-30 | 2003-09-18 | Golic Kent G. | Gene targeting method |
WO2004063356A2 (en) | 2003-01-13 | 2004-07-29 | Rao Mahendra S | Persistent expression of candidate molecule in proliferating stem and progenitor cells for delivery of therapeutic products |
US7888121B2 (en) | 2003-08-08 | 2011-02-15 | Sangamo Biosciences, Inc. | Methods and compositions for targeted cleavage and recombination |
US8409861B2 (en) | 2003-08-08 | 2013-04-02 | Sangamo Biosciences, Inc. | Targeted deletion of cellular DNA sequences |
EP1516924A1 (en) | 2003-09-17 | 2005-03-23 | Fundacion IVI para el Estudio de la reproduccion Humana (FIVIER) | Generation of human embryonic stem cells from triploid zygotes |
SG150567A1 (en) | 2004-03-23 | 2009-03-30 | Akaike Toshihiro | Pluripotent stem cell growing method |
EP1591521A1 (en) | 2004-04-30 | 2005-11-02 | Cellectis | I-Dmo I derivatives with enhanced activity at 37 degrees C and use thereof |
AU2005287278B2 (en) | 2004-09-16 | 2011-08-04 | Sangamo Biosciences, Inc. | Compositions and methods for protein production |
CA2827654C (en) | 2004-10-19 | 2019-04-02 | Regeneron Pharmaceuticals, Inc. | Method for generating an animal homozygous for a genetic modification |
FR2879622B1 (fr) | 2004-12-17 | 2008-02-01 | Agronomique Inst Nat Rech | Procede in vitro de production d'ovocytes ou d'oeufs presentant une modification genomique ciblee |
WO2006097784A1 (en) | 2005-03-15 | 2006-09-21 | Cellectis | I-crei meganuclease variants with modified specificity, method of preparation and uses thereof |
ATE466933T1 (de) | 2005-03-15 | 2010-05-15 | Cellectis | I-crei-meganuklease-varianten mit modifizierter spezifität sowie verfahren zu ihrer herstellung und verwendung |
GB0615327D0 (en) | 2006-03-30 | 2006-09-13 | Univ Edinburgh | Culture medium containing kinase inhibitors and uses thereof |
CA2638774C (en) | 2006-03-31 | 2015-11-24 | Medarex, Inc. | Transgenic animals expressing chimeric antibodies for use in preparing human antibodies |
CN101117633B (zh) | 2006-08-03 | 2011-07-20 | 上海交通大学附属儿童医院 | 一种细胞核移植方法 |
US8962311B2 (en) | 2006-08-09 | 2015-02-24 | Valneva | Method of obtaining chicken embryonic stem cells |
GB0623635D0 (en) | 2006-11-27 | 2007-01-03 | Stem Cell Sciences Uk Ltd | Pluripotent cell growth media |
WO2008076290A2 (en) | 2006-12-14 | 2008-06-26 | Dow Agrosciences Llc | Optimized non-canonical zinc finger proteins |
US7771967B2 (en) | 2006-12-22 | 2010-08-10 | The J. David Gladstone Institutes | Nucleic acid encoding apolipoprotein E-I3 |
WO2008133938A2 (en) | 2007-04-26 | 2008-11-06 | Sangamo Biosciences, Inc. | Targeted integration into the ppp1r12c locus |
EP2152880B1 (en) | 2007-06-01 | 2011-08-31 | Omt, Inc. | Compositions and methods for inhibiting endogenous immunoglobulin genes and producing transgenic human idiotype antibodies |
EP3156494B8 (en) | 2008-12-04 | 2018-09-19 | Sangamo Therapeutics, Inc. | Genome editing in rats using zinc-finger nucleases |
US20110239315A1 (en) | 2009-01-12 | 2011-09-29 | Ulla Bonas | Modular dna-binding domains and methods of use |
EP2206723A1 (en) | 2009-01-12 | 2010-07-14 | Bonas, Ulla | Modular DNA-binding domains |
JP5932632B2 (ja) | 2009-03-20 | 2016-06-15 | サンガモ バイオサイエンシーズ, インコーポレイテッド | 改変された亜鉛フィンガータンパク質を使用したcxcr4の修飾 |
US8772008B2 (en) | 2009-05-18 | 2014-07-08 | Sangamo Biosciences, Inc. | Methods and compositions for increasing nuclease activity |
US20120178647A1 (en) | 2009-08-03 | 2012-07-12 | The General Hospital Corporation | Engineering of zinc finger arrays by context-dependent assembly |
US10913929B2 (en) | 2009-10-13 | 2021-02-09 | Stemcell Technologies Inc. | Method of differentiating stem cells |
US20120276537A1 (en) | 2009-10-28 | 2012-11-01 | Kuehn Ralf | Homologous recombination in the oocyte |
WO2011059799A1 (en) | 2009-10-29 | 2011-05-19 | Regeneron Pharmaceuticals, Inc. | Multifunctional alleles |
US20120315670A1 (en) | 2009-11-02 | 2012-12-13 | Gen9, Inc. | Compositions and Methods for the Regulation of Multiple Genes of Interest in a Cell |
CA2782596A1 (en) | 2009-12-01 | 2011-06-09 | National Cancer Center | Method for constructing chimeric rat using rat embryonic stem cells |
PL2510096T5 (pl) | 2009-12-10 | 2018-06-29 | Regents Of The University Of Minnesota | Modyfikacja DNA zależna od efektora TAL |
DK2813572T3 (en) | 2009-12-21 | 2016-08-01 | Keygene Nv | Improved techniques for transfection of protoplasts |
CA2788850C (en) | 2010-02-09 | 2019-06-25 | Sangamo Biosciences, Inc. | Targeted genomic modification with partially single-stranded donor molecules |
GB201009732D0 (en) | 2010-06-10 | 2010-07-21 | Gene Bridges Gmbh | Direct cloning |
JP2013528062A (ja) * | 2010-06-11 | 2013-07-08 | リジェネロン・ファーマシューティカルズ・インコーポレイテッド | Xyes細胞からの繁殖可能なxy雌動物の生成 |
CA2805442C (en) | 2010-07-21 | 2020-05-12 | Sangamo Biosciences, Inc. | Methods and compositions for modification of an hla locus |
WO2012018726A1 (en) | 2010-08-02 | 2012-02-09 | Cellectis Sa | Method for increasing double-strand break-induced gene targeting |
WO2012129198A1 (en) | 2011-03-23 | 2012-09-27 | Transposagen Biopharmaceuticals, Inc. | Genetically modified rat models for obesity and diabetes |
RU2517731C2 (ru) * | 2011-07-08 | 2014-05-27 | Общество с ограниченной ответственностью "Биолайн Центр",RU | Способ получения трансгенных кур опосредованным переносом гена путем обычного искусственного осеменения |
SI2771357T1 (sl) | 2011-10-28 | 2018-11-30 | Regeneron Pharmaceuticals, Inc. | Genetsko T-celično receptorsko modificirane miši |
GB201122047D0 (en) * | 2011-12-21 | 2012-02-01 | Kymab Ltd | Transgenic animals |
WO2013141680A1 (en) | 2012-03-20 | 2013-09-26 | Vilnius University | RNA-DIRECTED DNA CLEAVAGE BY THE Cas9-crRNA COMPLEX |
US9637739B2 (en) | 2012-03-20 | 2017-05-02 | Vilnius University | RNA-directed DNA cleavage by the Cas9-crRNA complex |
SG10201702445TA (en) | 2012-04-25 | 2017-04-27 | Regeneron Pharma | Nuclease-mediated targeting with large targeting vectors |
RU2650819C2 (ru) | 2012-05-07 | 2018-04-17 | Сангамо Терапьютикс, Инк. | Способы и композиции для опосредованной нуклеазой направленной интеграции трансгенов |
EA038924B1 (ru) | 2012-05-25 | 2021-11-10 | Те Риджентс Оф Те Юниверсити Оф Калифорния | Способы и композиции рнк-специфической модификации днк-мишени и рнк-специфической модуляции транскрипции |
CN105441440B (zh) | 2012-10-23 | 2020-12-15 | 基因工具股份有限公司 | 包含特异于靶dna的向导rna和cas蛋白质编码核酸或cas蛋白质的用于切割靶dna的组合物及其用途 |
KR102531576B1 (ko) | 2012-12-06 | 2023-05-11 | 시그마-알드리치 컴퍼니., 엘엘씨 | Crispr-기초된 유전체 변형과 조절 |
JP6552965B2 (ja) | 2012-12-12 | 2019-07-31 | ザ・ブロード・インスティテュート・インコーポレイテッド | 配列操作のための改善された系、方法および酵素組成物のエンジニアリングおよび最適化 |
ES2883590T3 (es) | 2012-12-12 | 2021-12-09 | Broad Inst Inc | Suministro, modificación y optimización de sistemas, métodos y composiciones para la manipulación de secuencias y aplicaciones terapéuticas |
US8697359B1 (en) | 2012-12-12 | 2014-04-15 | The Broad Institute, Inc. | CRISPR-Cas systems and methods for altering expression of gene products |
RU2766685C2 (ru) | 2012-12-17 | 2022-03-15 | Президент Энд Фэллоуз Оф Харвард Коллидж | Рнк-направляемая инженерия генома человека |
ES2705033T3 (es) | 2012-12-27 | 2019-03-21 | Keygene Nv | Método para eliminar un ligamiento genético en una planta |
WO2014131833A1 (en) | 2013-02-27 | 2014-09-04 | Helmholtz Zentrum München Deutsches Forschungszentrum Für Gesundheit Und Umwelt (Gmbh) | Gene editing in the oocyte by cas9 nucleases |
US9234213B2 (en) | 2013-03-15 | 2016-01-12 | System Biosciences, Llc | Compositions and methods directed to CRISPR/Cas genomic engineering systems |
WO2014153470A2 (en) | 2013-03-21 | 2014-09-25 | Sangamo Biosciences, Inc. | Targeted disruption of t cell receptor genes using engineered zinc finger protein nucleases |
CN115261411A (zh) | 2013-04-04 | 2022-11-01 | 哈佛学院校长同事会 | 利用CRISPR/Cas系统的基因组编辑的治疗性用途 |
LT3456831T (lt) | 2013-04-16 | 2021-09-10 | Regeneron Pharmaceuticals, Inc. | Tikslinis žiurkės genomo modifikavimas |
US20160186208A1 (en) | 2013-04-16 | 2016-06-30 | Whitehead Institute For Biomedical Research | Methods of Mutating, Modifying or Modulating Nucleic Acid in a Cell or Nonhuman Mammal |
US20140359795A1 (en) | 2013-05-31 | 2014-12-04 | Recombinetics, Inc. | Genetic techniques for making animals with sortable sperm |
AU2013393832B2 (en) | 2013-07-11 | 2017-11-30 | Scinopharm Taiwan, Ltd. | Analytical method for detecting sulfated oligosaccharides |
WO2015040402A1 (en) | 2013-09-18 | 2015-03-26 | Kymab Limited | Methods. cells & organisms |
US10787684B2 (en) | 2013-11-19 | 2020-09-29 | President And Fellows Of Harvard College | Large gene excision and insertion |
WO2015088643A1 (en) | 2013-12-11 | 2015-06-18 | Regeneron Pharmaceuticals, Inc. | Methods and compositions for the targeted modification of a genome |
SG10201805815YA (en) | 2014-01-08 | 2018-08-30 | Harvard College | Rna-guided gene drives |
KR101823661B1 (ko) | 2014-04-24 | 2018-01-30 | 기초과학연구원 | 마이크로 상동 기반의 유전자 녹아웃을 위한 뉴클레아제 표적 서열을 확인하는 방법 |
GB201407852D0 (en) | 2014-05-02 | 2014-06-18 | Iontas Ltd | Preparation of libraries od protein variants expressed in eukaryotic cells and use for selecting binding molecules |
ES2784754T3 (es) | 2014-06-06 | 2020-09-30 | Regeneron Pharma | Métodos y composiciones para modificar un locus objetivo |
SI3161128T1 (sl) | 2014-06-26 | 2019-02-28 | Regeneron Pharmaceuticals, Inc. | Postopki in sestavki za ciljano genetsko spremembo in postopki uporabe |
WO2016061073A1 (en) | 2014-10-14 | 2016-04-21 | Memorial Sloan-Kettering Cancer Center | Composition and method for in vivo engineering of chromosomal rearrangements |
EP3561052A1 (en) | 2014-10-15 | 2019-10-30 | Regeneron Pharmaceuticals, Inc. | Methods and compositions for generating or maintaining pluripotent cells |
RS58893B1 (sr) | 2014-11-21 | 2019-08-30 | Regeneron Pharma | Postupci i kompozicije za ciljanu genetičku modifikaciju korišćenjem parnih vodećih rnk |
WO2016089866A1 (en) | 2014-12-01 | 2016-06-09 | President And Fellows Of Harvard College | Rna-guided systems for in vivo gene editing |
CN107208113A (zh) | 2014-12-19 | 2017-09-26 | 瑞泽恩制药公司 | 用于通过单步多重靶向进行靶向遗传修饰的方法和组合物 |
US20180092992A1 (en) | 2015-04-15 | 2018-04-05 | Hudson Institute of Medical Research | Method of treatment |
US9790490B2 (en) | 2015-06-18 | 2017-10-17 | The Broad Institute Inc. | CRISPR enzymes and systems |
-
2015
- 2015-06-26 SI SI201530433T patent/SI3161128T1/sl unknown
- 2015-06-26 RU RU2017101330A patent/RU2711740C2/ru active
- 2015-06-26 KR KR1020177001889A patent/KR102386101B1/ko active IP Right Grant
- 2015-06-26 US US14/751,807 patent/US9902971B2/en active Active
- 2015-06-26 HU HUE15745288A patent/HUE041584T2/hu unknown
- 2015-06-26 MX MX2016017317A patent/MX2016017317A/es active IP Right Grant
- 2015-06-26 EP EP15745288.9A patent/EP3161128B1/en active Active
- 2015-06-26 RS RS20181361A patent/RS58009B1/sr unknown
- 2015-06-26 ES ES15745288.9T patent/ES2694629T3/es active Active
- 2015-06-26 LT LTEP15745288.9T patent/LT3161128T/lt unknown
- 2015-06-26 PT PT15745288T patent/PT3161128T/pt unknown
- 2015-06-26 SG SG10201911411YA patent/SG10201911411YA/en unknown
- 2015-06-26 SG SG11201610633QA patent/SG11201610633QA/en unknown
- 2015-06-26 CN CN201580046401.3A patent/CN107002093B/zh active Active
- 2015-06-26 EP EP18188556.7A patent/EP3461885B1/en active Active
- 2015-06-26 KR KR1020227011704A patent/KR102468108B1/ko active IP Right Grant
- 2015-06-26 ES ES18188556T patent/ES2901074T3/es active Active
- 2015-06-26 RU RU2019143133A patent/RU2771532C2/ru active
- 2015-06-26 JP JP2016575039A patent/JP6752158B2/ja active Active
- 2015-06-26 AU AU2015279642A patent/AU2015279642B2/en active Active
- 2015-06-26 CA CA2953559A patent/CA2953559C/en active Active
- 2015-06-26 PL PL15745288T patent/PL3161128T3/pl unknown
- 2015-06-26 DK DK15745288.9T patent/DK3161128T3/en active
- 2015-06-26 WO PCT/US2015/038001 patent/WO2015200805A2/en active Application Filing
- 2015-06-26 CN CN202110608875.XA patent/CN113322277A/zh active Pending
- 2015-06-26 CA CA3172866A patent/CA3172866A1/en active Pending
- 2015-06-26 TR TR2018/16074T patent/TR201816074T4/tr unknown
- 2015-10-29 US US14/926,773 patent/US20160046960A1/en not_active Abandoned
-
2016
- 2016-12-19 IL IL249637A patent/IL249637B/en unknown
- 2016-12-20 MX MX2019012311A patent/MX2019012311A/es unknown
-
2018
- 2018-02-22 US US15/902,514 patent/US10793874B2/en active Active
- 2018-10-10 HR HRP20181630TT patent/HRP20181630T1/hr unknown
- 2018-11-01 CY CY181101136T patent/CY1120808T1/el unknown
-
2019
- 2019-09-17 JP JP2019168449A patent/JP6889762B2/ja active Active
-
2020
- 2020-08-31 US US17/007,984 patent/US20210024953A1/en active Pending
-
2021
- 2021-02-25 AU AU2021201239A patent/AU2021201239B2/en active Active
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
HRP20181630T1 (hr) | Postupci i kompoziti za ciljne genetske modifikacije i načini korištenja | |
EP3224353C0 (en) | TARGETED REMOVAL OF BACTERIAL GENES | |
HK1232163A1 (zh) | 用於抑制α- 抗胰蛋白酶基因表達的組合物及方法 | |
HUE056172T2 (hu) | Szelenoorganikus vegyületeket tartalmazó készítmények és eljárások alkalmazásukra | |
HK1252852A1 (zh) | 阻止HIF2α基因表達的組合物及方法 | |
ZA201701909B (en) | Trichoderma compositions and methods of use | |
ZA201803723B (en) | Compositions and methods for efficient targeting of transgenes | |
IL268570B (en) | Oligonucleotide preparations and methods for their preparation | |
EP3190886A4 (en) | Compositions and methods of use thereof | |
HK1243404A1 (zh) | 色酰胺組合物和使用方法 | |
HK1244782A1 (zh) | 用於治療疾病和病癥的組合物和方法 | |
EP3237619B8 (en) | Compositions and methods for inhibiting expression of adamts-5 and adam17 | |
GB2537518B (en) | Settable compositions and methods of use | |
GB201419559D0 (en) | Therapeutic compositions and methods | |
AU2014905067A0 (en) | Compositions and methods of use | |
AU2014902829A0 (en) | Compositions and Methods of Use |