WO2009095742A1
(en)
|
2008-01-31 |
2009-08-06 |
Cellectis |
New i-crei derived single-chain meganuclease and uses thereof
|
EP1591521A1
(en)
*
|
2004-04-30 |
2005-11-02 |
Cellectis |
I-Dmo I derivatives with enhanced activity at 37 degrees C and use thereof
|
WO2007034262A1
(en)
*
|
2005-09-19 |
2007-03-29 |
Cellectis |
Heterodimeric meganucleases and use thereof
|
EP2325307A1
(en)
*
|
2005-03-15 |
2011-05-25 |
Cellectis |
I-crel meganuclease variants with modified specificity, method of preparation and uses thereof
|
US8021867B2
(en)
|
2005-10-18 |
2011-09-20 |
Duke University |
Rationally-designed meganucleases with altered sequence specificity and DNA-binding affinity
|
WO2007049095A1
(en)
|
2005-10-25 |
2007-05-03 |
Cellectis |
Laglidadg homing endonuclease variants having mutations in two functional subdomains and use thereof
|
WO2007060495A1
(en)
|
2005-10-25 |
2007-05-31 |
Cellectis |
I-crei homing endonuclease variants having novel cleavage specificity and use thereof
|
WO2008093152A1
(en)
*
|
2007-02-01 |
2008-08-07 |
Cellectis |
Obligate heterodimer meganucleases and uses thereof
|
US20140112904A9
(en)
|
2007-06-06 |
2014-04-24 |
Cellectis |
Method for enhancing the cleavage activity of i-crei derived meganucleases
|
CA2691440A1
(en)
|
2007-06-29 |
2009-01-08 |
Pioneer Hi-Bred International, Inc. |
Methods for altering the genome of a monocot plant cell
|
WO2009013559A1
(en)
|
2007-07-23 |
2009-01-29 |
Cellectis |
Meganuclease variants cleaving a dna target sequence from the human hemoglobin beta gene and uses thereof
|
WO2009114321A2
(en)
|
2008-03-11 |
2009-09-17 |
Precision Biosciencs, Inc. |
Rationally-designed meganucleases for maize genome engineering
|
WO2010001189A1
(en)
*
|
2008-07-03 |
2010-01-07 |
Cellectis |
The crystal structure of i-dmoi in complex with its dna target, improved chimeric meganucleases and uses thereof
|
EP3495478A3
(en)
|
2008-07-14 |
2019-07-24 |
Precision Biosciences, Inc. |
Recognition sequences for i-crei-derived meganucleases and uses thereof
|
WO2010136981A2
(en)
|
2009-05-26 |
2010-12-02 |
Cellectis |
Meganuclease variants cleaving the genome of a pathogenic non-integrating virus and uses thereof
|
WO2011007193A1
(en)
|
2009-07-17 |
2011-01-20 |
Cellectis |
Viral vectors encoding a dna repair matrix and containing a virion-associated site specific meganuclease for gene targeting
|
WO2011021062A1
(en)
|
2009-08-21 |
2011-02-24 |
Cellectis |
Meganuclease variants cleaving a dna target sequence from the human lysosomal acid alpha-glucosidase gene and uses thereof
|
CA2781693C
(en)
*
|
2009-11-27 |
2018-12-18 |
Basf Plant Science Company Gmbh |
Chimeric endonucleases and uses thereof
|
CN102762726A
(en)
*
|
2009-11-27 |
2012-10-31 |
巴斯夫植物科学有限公司 |
Chimeric endonucleases and uses thereof
|
WO2011082310A2
(en)
|
2009-12-30 |
2011-07-07 |
Pioneer Hi-Bred International, Inc. |
Methods and compositions for targeted polynucleotide modification
|
WO2011101696A1
(en)
|
2010-02-18 |
2011-08-25 |
Cellectis |
Improved meganuclease recombination system
|
EP2569424A1
(en)
|
2010-05-12 |
2013-03-20 |
Cellectis |
Meganuclease variants cleaving a dna target sequence from the dystrophin gene and uses thereof
|
US20130183282A1
(en)
|
2010-05-12 |
2013-07-18 |
Cellectis |
Meganuclease variants cleaving a DNA target sequence from the rhodopsin gene and uses thereof
|
CA2802822A1
(en)
|
2010-06-15 |
2012-01-05 |
Cellectis |
Method for improving cleavage of dna by endonuclease sensitive to methylation
|
EP2591098A2
(en)
|
2010-07-07 |
2013-05-15 |
Cellectis |
Meganucleases variants cleaving a dna target sequence in the nanog gene and uses thereof
|
WO2012010976A2
(en)
|
2010-07-15 |
2012-01-26 |
Cellectis |
Meganuclease variants cleaving a dna target sequence in the tert gene and uses thereof
|
WO2012007848A2
(en)
|
2010-07-16 |
2012-01-19 |
Cellectis |
Meganuclease variants cleaving a dna target sequence in the was gene and uses thereof
|
US20130337454A1
(en)
|
2010-10-27 |
2013-12-19 |
Philippe Duchateau |
Method for increasing the efficiency of double-strand break-induced mutagenesis
|
EA201391373A1
(en)
|
2011-03-23 |
2014-07-30 |
Пайонир Хай-Бред Интернэшнл, Инк. |
METHODS OF OBTAINING A COMPLEX LOCUS OF TRANSGENIC SIGNS
|
WO2012138901A1
(en)
|
2011-04-05 |
2012-10-11 |
Cellectis Sa |
Method for enhancing rare-cutting endonuclease efficiency and uses thereof
|
KR101982360B1
(en)
|
2011-04-05 |
2019-05-24 |
셀렉티스 |
Method for the generation of compact tale-nucleases and uses thereof
|
WO2012149470A1
(en)
|
2011-04-27 |
2012-11-01 |
Amyris, Inc. |
Methods for genomic modification
|
US9758796B2
(en)
|
2011-06-10 |
2017-09-12 |
Basf Plant Science Company Gmbh |
Nuclease fusion protein and uses thereof
|
CA2844470A1
(en)
|
2011-06-21 |
2013-05-10 |
Pioneer Hi-Bred International, Inc. |
Methods and compositions for producing male sterile plants
|
WO2013009525A1
(en)
|
2011-07-08 |
2013-01-17 |
Cellectis S.A. |
Method for increasing the efficiency of double-strand break-induced mutagenssis
|
EP2739739A1
(en)
|
2011-08-03 |
2014-06-11 |
E. I. Du Pont de Nemours and Company |
Methods and compositions for targeted integration in a plant
|
BR112014027468A2
(en)
|
2012-05-04 |
2017-06-27 |
Du Pont |
isolated or recombinant polynucleotide, recombinant DNA construction, cell, plant, plant explant, transgenic seed, isolated polypeptide, composition, methods of producing meganuclease, introducing disruption and integrating a polynucleotide.
|
JP6475172B2
(en)
|
2013-02-20 |
2019-02-27 |
リジェネロン・ファーマシューティカルズ・インコーポレイテッドRegeneron Pharmaceuticals, Inc. |
Rat genetic recombination
|
CA2905289C
(en)
|
2013-03-12 |
2023-03-07 |
Pioneer Hi-Bred International, Inc. |
Methods for the identification of variant recognition sites for rare-cutting engineered double-strand-break-inducing agents and compositions and uses thereof
|
RS62263B1
(en)
|
2013-04-16 |
2021-09-30 |
Regeneron Pharma |
Targeted modification of rat genome
|
RU2725520C2
(en)
|
2013-12-11 |
2020-07-02 |
Регенерон Фармасьютикалс, Инк. |
Methods and compositions for genome targeted modification
|
EP3460063B1
(en)
|
2013-12-11 |
2024-03-13 |
Regeneron Pharmaceuticals, Inc. |
Methods and compositions for the targeted modification of a genome
|
KR102274445B1
(en)
|
2013-12-19 |
2021-07-08 |
아미리스 인코퍼레이티드 |
Methods for genomic integration
|
EP3708671A1
(en)
|
2014-06-06 |
2020-09-16 |
Regeneron Pharmaceuticals, Inc. |
Methods and compositions for modifying a targeted locus
|
CA2953499C
(en)
|
2014-06-23 |
2023-10-24 |
Regeneron Pharmaceuticals, Inc. |
Nuclease-mediated dna assembly
|
US9902971B2
(en)
|
2014-06-26 |
2018-02-27 |
Regeneron Pharmaceuticals, Inc. |
Methods for producing a mouse XY embryonic (ES) cell line capable of producing a fertile XY female mouse in an F0 generation
|
ES2741387T3
(en)
|
2014-10-15 |
2020-02-10 |
Regeneron Pharma |
Methods and compositions for generating or maintaining pluripotent cells
|
WO2016100819A1
(en)
|
2014-12-19 |
2016-06-23 |
Regeneron Pharmaceuticals, Inc. |
Methods and compositions for targeted genetic modification through single-step multiple targeting
|
US11293033B2
(en)
|
2016-05-18 |
2022-04-05 |
Amyris, Inc. |
Compositions and methods for genomic integration of nucleic acids into exogenous landing pads
|
AU2017302657A1
(en)
|
2016-07-29 |
2019-02-14 |
Regeneron Pharmaceuticals, Inc. |
Mice comprising mutations resulting in expression of c-truncated fibrillin-1
|
AU2018325363A1
(en)
|
2017-08-29 |
2020-04-09 |
Global Crop Innovations Pty. Ltd. |
Improved BLue Aleurone and other segregation systems
|
BR112020003609A2
(en)
|
2017-09-29 |
2020-09-01 |
Regeneron Pharmaceuticals, Inc. |
system and method for forming an emulsion
|
KR20200071198A
(en)
|
2018-12-10 |
2020-06-19 |
네오이뮨텍, 인코퍼레이티드 |
Development of new adoptive T cell immunotherapy by modification of Nrf2 expression
|
CA3120799A1
(en)
|
2018-12-20 |
2020-06-25 |
Regeneron Pharmaceuticals, Inc. |
Nuclease-mediated repeat expansion
|
CA3133359C
(en)
|
2019-04-04 |
2023-04-11 |
Regeneron Pharmaceuticals, Inc. |
Methods for scarless introduction of targeted modifications into targeting vectors
|
SG11202108454RA
(en)
|
2019-04-04 |
2021-09-29 |
Regeneron Pharma |
Non-human animals comprising a humanized coagulation factor 12 locus
|
JP2022534867A
(en)
|
2019-06-04 |
2022-08-04 |
リジェネロン・ファーマシューティカルズ・インコーポレイテッド |
Non-human animals containing humanized TTR loci with beta slip mutations and methods of use
|
CN113939595A
(en)
|
2019-06-07 |
2022-01-14 |
瑞泽恩制药公司 |
Non-human animals including humanized albumin loci
|
WO2021108363A1
(en)
|
2019-11-25 |
2021-06-03 |
Regeneron Pharmaceuticals, Inc. |
Crispr/cas-mediated upregulation of humanized ttr allele
|
US20240247285A1
(en)
|
2021-05-10 |
2024-07-25 |
Sqz Biotechnologies Company |
Methods for delivering genome editing molecules to the nucleus or cytosol of a cell and uses thereof
|
WO2022251644A1
(en)
|
2021-05-28 |
2022-12-01 |
Lyell Immunopharma, Inc. |
Nr4a3-deficient immune cells and uses thereof
|
EP4347826A1
(en)
|
2021-06-02 |
2024-04-10 |
Lyell Immunopharma, Inc. |
Nr4a3-deficient immune cells and uses thereof
|
KR20240082391A
(en)
|
2021-10-14 |
2024-06-10 |
론자 세일즈 아게 |
Modified producer cells for extracellular vesicle production
|
WO2023129974A1
(en)
|
2021-12-29 |
2023-07-06 |
Bristol-Myers Squibb Company |
Generation of landing pad cell lines
|
WO2023220603A1
(en)
|
2022-05-09 |
2023-11-16 |
Regeneron Pharmaceuticals, Inc. |
Vectors and methods for in vivo antibody production
|
WO2023225665A1
(en)
|
2022-05-19 |
2023-11-23 |
Lyell Immunopharma, Inc. |
Polynucleotides targeting nr4a3 and uses thereof
|
WO2024064952A1
(en)
|
2022-09-23 |
2024-03-28 |
Lyell Immunopharma, Inc. |
Methods for culturing nr4a-deficient cells overexpressing c-jun
|
WO2024064958A1
(en)
|
2022-09-23 |
2024-03-28 |
Lyell Immunopharma, Inc. |
Methods for culturing nr4a-deficient cells
|
WO2024077174A1
(en)
|
2022-10-05 |
2024-04-11 |
Lyell Immunopharma, Inc. |
Methods for culturing nr4a-deficient cells
|